Role of heterotrimeric G proteins in platelet activation and clot formation in platelets treated with integrin αIIbβ3 inhibitor

References

• Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res 2006;99(12):1293–1304.
   PubMed Web of Science ®Google Scholar
• Shankar H, Kahner B, Kunapuli SP. G-protein dependent platelet signaling: Perspectives for therapy. Current Drug Targets 2006;7(10):1253–1263.
   PubMed Web of Science ®Google Scholar
• Shen B, Delaney KM, Du X. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opin Cell Biol 2012;24(5):600–606.
   PubMed Web of Science ®Google Scholar
• Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol 2007;71(5):1399–1406.
   PubMed Web of Science ®Google Scholar
• Soh UJ, Dores MR, Chen B, Trejo J. Signal transduction by protease-activated receptors. Br J Pharmacol 2010;160(2):191–203.
   PubMed Web of Science ®Google Scholar
• Sidhu TS, French SL, Hamilton JR. Differential signaling by protease-activated receptors: Implications for therapeutic targeting. Int J Mol Sci 2014;15(4):6169–6183.
   PubMed Web of Science ®Google Scholar
• Jin J, Quinton TM, Zhang J, Rittenhouse SE, Kunapuli SP. Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha (IIb)bet (3) and ADP receptors. Blood 2002;99:193–198.
   PubMed Web of Science ®Google Scholar
• Bhavaraju K, Lakhani PR, Dorsam RT, Jin J, Hitchcock JS, Sanjay A, Kunapuli SP. G signaling pathways substitute for integrin a2bβ3 signaling for thromboxane generation in platelets. PloS ONE 2011;6:e16586–94.
   PubMed Web of Science ®Google Scholar
• Kunapuli SP. Functional characterization of platelet ADP receptors. Platelets 1998;9:343–351.
   PubMed Web of Science ®Google Scholar
• Kahner BN, Quinton TM, Langan S, Kunapuli ST. Do heterotrimeric G proteins redistribute upon G protein-coupled receptor stimulation in platelets? Platelets 2006;17(6):397–404.
   PubMed Web of Science ®Google Scholar
• Knezevic I, Borg C, Le Breton GC. Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors. J Biol Chem 1993;268(34):26011–26017.
   PubMed Web of Science ®Google Scholar
• Offermanns S, Laugwitz KL, Spicher K, Schultz G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci U S A 1994;91(2):504–508.
   PubMed Web of Science ®Google Scholar
• Dorsam R, Kim S, Jin J, Kunapuli P. Coordinated signaling through both G12/13 and Gi pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem 2002;277(49):47588–47595.
   PubMed Web of Science ®Google Scholar
• Hynes RO. Integrins: Bidirectional, allosteric signaling machines. Cell 2002;110(6):673–687.
   PubMed Web of Science ®Google Scholar
• Holme PA, Brosstad F, Solum NO. Platelet-derived microvesicles and activated platelets express factor Xa activity. Blood Coagul Fibrinolysis 1995;6:302–310.
   PubMed Web of Science ®Google Scholar
• Ono A, Westein E, Hsiao S, Nessbitt WS, Hamilton JR, Schoenwaelder SM, Jackson SP. Identification of a fibrin-independent contractile mechanism regulating primary hemostasis and thrombus growth. Blood 2008;12(1):90–99.
   Google Scholar
• Lhermusier T, Chap H, Payrastre B. Platelet membrane phospholipid asymmetry: From the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome. J Thromb Haemost 2011;9:1883–1891.
   PubMed Web of Science ®Google Scholar
• Bowbrick VA, Mikhailidis DP, Stansby G. Influence of platelet count and activity on thromboelastography parameters. Platelets 2003;14:219–224.
   PubMed Web of Science ®Google Scholar
• Misgav M, Shenkman B, Budnik I, Einav Y, Martinowitz U. Distinct effects of fibrinogen and von Willebrand factor on clot formation and platelet adhesion in reconstituted and immune thrombocytopenia. Anesth Analg 2011;112:1034–1040.
   PubMed Web of Science ®Google Scholar
• Shenkman B, Livnat T, Misgav M, Budnik I, Einav Y, Martinowitz U. The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann’s Thrombasthenia blood. Platelets 2012;23(8):604–610.
   PubMed Web of Science ®Google Scholar
• Solomon C, Ranucci M, Hochleitner G, Schochl H, Schlimp CJ. Assessing the methodology for calculating platelet contribution to clot strength (platelet component) in thromboelastometry and thromboelastigraphy. Anesth Analg 2015;121:868–878.
   PubMed Web of Science ®Google Scholar
• Budnik I, Shenkman B, Savion N. Role of G protein signaling in the formation of the fibrin(ogen)-integrin-actin cytoskeleton complex in platelets. Platelets 2016, 27(6):563–575.
   PubMed Web of Science ®Google Scholar
• Malmsten C, Kindahl H, Samuelsson B, Levy-Toledano S, Tobelem G. Thromboxane synthesis and the platelet release reaction in Bernard-Soulier syndrome, thrombasthenia Glanzmann and Hermansky-Pudlak syndrome. Br J Haematol 1977;35:511–520.
   PubMed Web of Science ®Google Scholar
• Jin J, Kunapuli SP. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci U S A 1998;95(14):8070–8074.
   PubMed Web of Science ®Google Scholar
• Klages, B, Brandt, U, Simon, MI, Schultz, G, Offermanns, S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999;144:745–754.
   PubMed Web of Science ®Google Scholar
• Minuz P, FumagalliL, Gaino S, Tommasoli RM, Degan M, Cavallini C, Lecchi A, Cattaneo M, Lechi Santonastaso C, Berton G. Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets. Biochem J 2006;400:127–134.
   PubMed Web of Science ®Google Scholar
• Nieswandt B, Schulte V, Zywietz A, Gratacap MP, Offermanns S. Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem 2002;277(42):39493–39498.
   PubMed Web of Science ®Google Scholar
• Jantzen HM, Milstone DS, Gousset L, Conley PB, Mortensen RM. Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest 2001;108(3):477–483.
   PubMed Web of Science ®Google Scholar
• Needham LK, Rozengurt, E. Gα12 and Gα13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate. J Biol Chem 1998;273:14626–14632.
   PubMed Web of Science ®Google Scholar