519
Views
13
CrossRef citations to date
0
Altmetric
Systematic review

Efficacy and safety of thrombopoietin receptor agonists in children with chronic immune thrombocytopenic purpura: meta-analysis

, ORCID Icon &
Pages 828-835 | Received 15 Sep 2017, Accepted 03 Apr 2018, Published online: 27 Feb 2019

References

  • Kühne T, Berchtold W, Michaels LA, Wu R, Donato H, Espina B, Tamary H, Rodeghiero F, Chitlur M, Rischewski J. Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group. Haematologica 2011;96(12):1831–1837. doi:10.3324/haematol.2011.050799
  • Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004;76(6):628–638. doi:10.1016/j.clpt.2004.08.010
  • Escudero Vilaplana V, Aragonés JH, Fernandez-Llamazares CM, Bieler CB, Rodríguez SM, Sáez MS. Use of romiplostim for primary immune thrombocytopenia in children. Pediatr Hematol Oncol 2012;29(2):197–205. doi:10.3109/08880018.2011.629401
  • Pasquet M, Aladjidi N, Guiton C, Courcoux MF, Munzer M, Auvrignon A, Lutz P, Ducassou S, Leroy G, Munzer C, et al. Romiplostim in children with chronic immune thrombocytopenia (ITP): the French experience. Br J Haematol 2014;164(2):266–271. doi:10.1111/bjh.12609
  • Mokhtar GM, Tantawy AA, El Sherif NH. Romiplostim therapy in children with unresponsive chronic immune thrombocytopenia. Platelets 2012;23(4):264–273. doi:10.3109/09537104.2011.619601
  • D’Orazio JA, Neely J, Farhoudi N. ITP in children: pathophysiology and current treatment approaches. J Pediatr Hematol Oncol 2013;35(1):1–13. doi:10.1097/MPH.0b013e318271f457
  • Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, et al. Thrombopoietin receptor agonist use in children: data from the pediatric ITP consortium of North America ICON2 Study. Pediatr Blood Cancer 2016;63(8):1407–1413. doi:10.1002/pbc.26003
  • Wang L, Gao Z, Chen X-P, Zhang H-Y, Yang N, Wang F-Y,  Guan L-X, Gu Z-Y, Zhao S-S, Luo L, et al. Efficacy and safety of thrombopoietin receptor agonists in patients with primary immune thrombocytopenia: a systematic review and meta-analysis. Sci Rep 2016;6. doi:10.1038/srep39003
  • Nguyen -T-TL, Palmaro A, Montastruc F, Lapeyre-Mestre M, Moulis G. Signal for thrombosis with eltrombopag and romiplostim: a disproportionality analysis of spontaneous reports within VigiBase®. Drug Saf 2015;38(12):1179–1186. doi:10.1007/s40264-015-0337-1
  • Garzon AM, Mitchell WB. Use of thrombopoietin receptor agonists in childhood immune thrombocytopenia. Front Pediatr 2015;3:70. doi:10.3389/fped.2015.00070
  • Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology 1999;37–48. doi:10.1097/00001648-199901000-00008
  • Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj 1997;315(7109):629–634.
  • Terrin N, Schmid CH, Lau J, Olkin I. Adjusting for publication bias in the presence of heterogeneity. Stat Med 2003;22(13):2113–2126. doi:10.1002/sim.1461
  • Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. Bmj 2015;349:g7647. doi:10.1136/bmj.g7647
  • Tarantino MD, Bussel JB, Blanchette VS, Despotovic J, Bennett C, Raj A, Williams B, Beam D, Morales J, Rose MJ, et al. Romiplostim in children with immune thrombocytopenia: a phase 3, randomised, double-blind, placebo-controlled study. Lancet 2016;388(10039):45–54. doi:10.1016/S0140-6736(16)00279-8
  • Bussel JB, Buchanan GR, Nugent DJ, Gnarra DJ, Bomgaars LR, Blanchette VS, Wang YM, Nie K, Jun S., et al. A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia. Blood 2011;118(1):28–36. doi:10.1182/blood-2010-10-313908
  • Elalfy MS, Abdelmaksoud AA, Eltonbary KY. Romiplostim in children with chronic refractory ITP: randomized placebo controlled study. Ann Hematol 2011;90(11):1341–1344. doi:10.1007/s00277-011-1172-9
  • Grainger JD, Locatelli F, Chotsampancharoen T, Donyush E, Pongtanakul B, Komvilaisak P, Sosothikul D, Drelichman G, Sirachainan N, Holzhauer S, et al. Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial. Lancet 2015;386(10004):1649–1658. doi:10.1016/S0140-6736(15)61107-2
  • Bussel JB, De Miguel PG, Despotovic JM, Grainger JD, Sevilla J, Blanchette VS, Krishnamurti L, Connor P, David M9, Boayue KB et al. Eltrombopag for the treatment of children with persistent and chronic immune thrombocytopenia (PETIT): a randomised, multicentre, placebo-controlled study. Lancet Haematol 2015;2(8):e315–e25. doi:10.1016/S2352-3026(15)00114-3
  • Higgins Jp, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD,  Savovic J, Schulz KF, Weeks L, Sterne JA, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. Bmj 2011;343:d5928. doi:10.1136/bmj.d5928
  • Elgebaly AS, El Ashal G, Elfil M, Menshawy A. Tolerability and efficacy of eltrombopag in chronic immune thrombocytopenia meta-analysis of randomized controlled trials. Clin Appl Thrombosis/Hemostasis 2017;23(8):928-937.doi:10.1177/1076029616663849
  • Zeng Y, Duan X, Xu J, Ni X. TPO receptor agonist for chronic idiopathic thrombocytopenic purpura. Cochrane Lib 2011; (7):CD008235. doi:10.1002/14651858

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.