Acute exercise-induced changes in hemostatic and fibrinolytic properties: analogies, similarities, and differences between normotensive subjects and patients with essential hypertension

References

• Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985;100(2):126–131.
   PubMed Web of Science ®Google Scholar
• Oja P, Titze S. Physical activity recommendations for public health: development and policy context. EPMA J. 2011;2(3):253–259. doi:10.1007/s13167-011-0090-1
   PubMedGoogle Scholar
• Foulds HJ, Bredin SS, Charlesworth SA, Ivey AC, Warburton DE. Exercise volume and intensity: a dose-response relationship with health benefits. Eur J Appl Physiol. 2014;114(8):1563–1571. doi:10.1007/s00421-014-2887-9
   PubMed Web of Science ®Google Scholar
• Pate RR, Pratt M, Blair SN, Haskell WL, Macera CA, Bouchard C, Buchner D, Ettinger W, Heath GW, King AC, et al. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. Jama. 1995;273(5):402–407.
   PubMed Web of Science ®Google Scholar
• Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793–801. doi:10.1056/NEJMoa011858
   PubMed Web of Science ®Google Scholar
• Fagard RH, Cornelissen VA. Effect of exercise on blood pressure control in hypertensive patients. Eur J Cardiovasc Prev Rehabil. 2007;14(1):12–17. doi:10.1097/HJR.0b013e3280128bbb
   PubMedGoogle Scholar
• Jensen-Urstad M. Sudden death and physical activity in athletes and nonathletes. Scand J Med Sci Sports. 1995;5(5):279–284.
   PubMedGoogle Scholar
• Warburton D, Taunton J, Bredin SSD, Isserow S. The risk-benefit paradox of exercise. BCMJ. 2016;58:210–218.
   Web of Science ®Google Scholar
• Siscovick DS, Weiss NS, Fletcher RH, Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl J Med. 1984;311(14):874–877. doi:10.1056/NEJM198410043111402
   PubMed Web of Science ®Google Scholar
• Manolis AJ, Beldekos D, Hatzissavas J, Foussas S, Cokkinos D, Bresnahan M, Gavras I, Gavras H. Hemodynamic and humoral correlates in essential hypertension: relationship between patterns of LVH and myocardial ischemia. Hypertension. 1997;30(3 Pt 2):730–734.
   PubMed Web of Science ®Google Scholar
• Gabbasov Z, Parfyonova Y, Popov E, Gavrilov I, Anuchin V, Dubov P, Djakonova Y. Association of platelet function in hypertensive patients with left ventricular hypertrophy, transient myocardial ischemia, and coronary artery disease. Platelets. 1998;9(3–4):191–195. doi:10.1080/09537109876672
   PubMed Web of Science ®Google Scholar
• Tubau JF, Szlachcic J, Braun S, Massie BM. Impaired left ventricular functional reserve in hypertensive patients with left ventricular hypertrophy. Hypertension. 1989;14(1):1–8.
   PubMed Web of Science ®Google Scholar
• Messerli FH. Hypertension and sudden cardiac death. Am J Hypertens. 1999;12(12 Pt 3):181S–188S. doi:10.1016/S0895-7061(99)00106-5
   PubMed Web of Science ®Google Scholar
• Laukkanen JA, Willeit P, Kurl S, Mäkikallio TH, Savonen K, Ronkainen K, Rauramaa R. Elevated systolic blood pressure during recovery from exercise and the risk of sudden cardiac death. J Hypertens. 2014;32(3):659–666. doi:10.1097/HJH.0000000000000066
   PubMed Web of Science ®Google Scholar
• Lip GY, Blann AD, Zarifis J, Beevers M, Lip PL, Beevers DG. Soluble adhesion molecule P-selectin and endothelial dysfunction in essential hypertension: implications for atherogenesis? A preliminary report. J Hypertens. 1995;13(12 Pt 2):1674–1678.
   PubMed Web of Science ®Google Scholar
• Lip GY, Blann AD, Jones AF, Lip PL, Beevers DG. Relation of endothelium, thrombogenesis, and hemorheology in systemic hypertension to ethnicity and left ventricular hypertrophy. Am J Cardiol. 1997;80(12):1566–1571.
   PubMed Web of Science ®Google Scholar
• Gleerup G, Winther K. Decreased fibrinolytic activity and increased platelet function in hypertension. Possible influence of calcium antagonism. Am J Hypertens. 1991;4(2 Pt 2):168S–171S. doi:10.1093/ajh/4.2.168S
   PubMed Web of Science ®Google Scholar
• Jansson JH, Johansson B, Boman K, Nilsson TK. Hypo-fibrinolysis in patients with hypertension and elevated cholesterol. J Intern Med. 1991;229(4):309–316.
   PubMed Web of Science ®Google Scholar
• Palermo A, Bertalero P, Pizza N, Amelotti R, Libretti A. Decreased fibrinolytic response to adrenergic stimulation in hypertensive patients. J Hypertens Suppl. 1989;7(6):S162–3.
   PubMedGoogle Scholar
• Ozkan G, Ulusoy S, Sönmez M, Karahan SC, Menteşe A, Kaynar K, Bektaş O. Thrombin activatable fibrinolysis inhibitor (TAFI) levels in hypertensive patients and a comparison of the effects of amlodipine and ramipril on TAFI levels. Clin Exp Hypertens. 2013;35(2):134–140. doi:10.3109/10641963.2012.702833
   PubMed Web of Science ®Google Scholar
• Winther K, Gleerup G, Hedner T. Platelet function and fibrinolytic activity in hypertension: differential effects of calcium antagonists and beta-adrenergic receptor blockers. J Cardiovasc Pharmacol. 1991;18(Suppl 9):S41–4.
   PubMedGoogle Scholar
• Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation. 1993;87(5):1468–1474.
   PubMed Web of Science ®Google Scholar
• Chi DS, Jin FX, Su YW, Yang SG, Ge B, Wu BM, Hong XS, Yu RS. Coagulative and fibrinolytic changes in patients with essential hypertension and the effect of sustained-release nifedipine. Di Yi Jun Yi Da Xue Xue Bao. 2002;22:168–170.
   PubMedGoogle Scholar
• Ridker PM, Gaboury CL, Conlin PR, Seely EW, Williams GH, Vaughan DE. Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function. Circulation. 1993;87(6):1969–1973.
   PubMed Web of Science ®Google Scholar
• Cacciatore F, Bruzzese G, Vitale DF, Liguori A, de Nigris F, Fiorito C, Infante T, Donatelli F, Minucci PB, Ignarro LJ, et al. Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. Eur J Clin Pharmacol. 2011;67(9):877–883. doi:10.1007/s00228-011-1029-0
   PubMed Web of Science ®Google Scholar
• Poli KA, Tofler GH, Larson MG, Evans JC, Sutherland PA, Lipinska I, Mittleman MA, Muller JE, D’Agostino RB, Wilson PW, et al. Association of blood pressure with fibrinolytic potential in the Framingham offspring population. Circulation. 2000;101(3):264–269.
   PubMed Web of Science ®Google Scholar
• Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol. 2004;44(2):415–422. doi:10.1016/j.jacc.2004.03.067
   PubMed Web of Science ®Google Scholar
• Gavriilaki E, Gkaliagkousi E, Nikolaidou B, Triantafyllou G, Chatzopoulou F, Douma S. Increased thrombotic and impaired fibrinolytic response to acute exercise in patients with essential hypertension: the effect of treatment with an angiotensin II receptor blocker. J Hum Hypertens. 2014;28(10):606–609. doi:10.1038/jhh.2014.18
   PubMed Web of Science ®Google Scholar
• Gleerup G, Vind J, Winther K. Platelet function and fibrinolytic activity during rest and exercise in borderline hypertensive patients. Eur J Clin Invest. 1995;25(4):266–270.
   PubMed Web of Science ®Google Scholar
• Gkaliagkousi E, Gavriilaki E, Yiannaki E, Markala D, Papadopoulos N, Triantafyllou A, Anyfanti P, Petidis K, Garypidou V, Doumas M, et al. Platelet activation in essential hypertension during exercise: pre- and post-treatment changes with an angiotensin II receptor blocker. Am J Hypertens. 2014;27(4):571–578. doi:10.1093/ajh/hpt153
   PubMed Web of Science ®Google Scholar
• Hong S, Adler KA, Von Känel R, Nordberg J, Ziegler MG, Mills PJ. Prolonged platelet activation in individuals with elevated blood pressure in response to a moderate exercise challenge. Psychophysiology. 2009;46(2):276–284. doi:10.1111/j.1469-8986.2008.00779.x
   PubMed Web of Science ®Google Scholar
• Vaziri ND, Smith DH, Winer RL, Weber MA, Gonzales EC, Neutel JM. Coagulation and inhibitory and fibrinolytic proteins in essential hypertension. J Am Soc Nephrol. 1993;4(2):222–228.
   PubMed Web of Science ®Google Scholar
• Braschi A. Potential protective role of blood pressure-lowering drugs on the balance between hemostasis and fibrinolysis in hypertensive patients at rest and during exercise. Am J Cardiovasc Drugs. 2019;19(2):133–171. doi:10.1007/s40256-018-00316-2
   PubMed Web of Science ®Google Scholar
• Froelich JW, Strauss HW, Moore RH, McKusick KA. Redistribution of visceral blood volume in upright exercise in healthy volunteers. J Nucl Med. 1988;29(10):1714–1718.
   PubMed Web of Science ®Google Scholar
• Peters AM, Allsop P, Stuttle AW, Arnot RN, Gwilliam M, Hall GM. Granulocyte margination in the human lung and its response to strenuous exercise. Clin Sci (Lond). 1992;82(2):237–244.
   PubMed Web of Science ®Google Scholar
• Schmidt KG, Rasmussen JW. Exercise-induced changes in the in vivo distribution of 111In-labelled platelets. Scand J Haematol. 1984;32(2):159–166.
   PubMedGoogle Scholar
• Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol (1985). 1993;75(2):668–674. doi:10.1152/jappl.1993.75.2.668
   PubMed Web of Science ®Google Scholar
• Cadroy Y, Pillard F, Sakariassen KS, Thalamas C, Boneu B, Riviere D. Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers. J Appl Physiol (1985). 2002;93(3):829–833. doi:10.1152/japplphysiol.00206.2002
   PubMed Web of Science ®Google Scholar
• Lippi G, Banfi G, Montagnana M, Salvagno GL, Schena F, Guidi GC. Acute variation of leucocytes counts following a half-marathon run. Int J Lab Hematol. 2010;32(1 Pt 2):117–121. doi:10.1111/j.1751-553X.2008.01133.x
   PubMed Web of Science ®Google Scholar
• Chamberlain KG, Tong M, Penington DG. Properties of the exchangeable splenic platelets released into the circulation during exercise-induced thrombocytosis. Am J Hematol. 1990;34(3):161–168.
   PubMed Web of Science ®Google Scholar
• Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscler Thromb Vasc Biol. 1995;15(10):1668–1674.
   PubMed Web of Science ®Google Scholar
• Di Massimo C, Scarpelli P, Penco M, Tozzi-Ciancarelli MG. Possible involvement of plasma antioxidant defences in training-associated decrease of platelet responsiveness in humans. Eur J Appl Physiol. 2004;91(4):406–412. doi:10.1007/s00421-003-0998-9
   PubMed Web of Science ®Google Scholar
• Wang JS, Jen CJ, Chen HI. Effects of chronic exercise and deconditioning on platelet function in women. J Appl Physiol (1985). 1997;83(6):2080–2085. doi:10.1152/jappl.1997.83.6.2080
   PubMed Web of Science ®Google Scholar
• Feng DL, Murillo J, Jadhav P, McKenna C, Gebara OC, Lipinska I, Muller JE, Tofler GH. Upright posture and maximal exercise increase platelet aggregability and prostacyclin production in healthy male subjects. Br J Sports Med. 1999;33(6):401–404. doi:10.1136/bjsm.33.6.401
   PubMed Web of Science ®Google Scholar
• Ikarugi H, Taka T, Nakajima S, Noguchi T, Watanabe S, Sasaki Y, Haga S, Ueda T, Seki J, Yamamoto J. Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans. J Appl Physiol (1985). 1999;86(1):133–138. doi:10.1152/jappl.1999.86.1.133
   PubMed Web of Science ®Google Scholar
• Ikarugi H, Shibata M, Shibata S, Ishii H, Taka T, Yamamoto J. High intensity exercise enhances platelet reactivity to shear stress and coagulation during and after exercise. Pathophysiol Haemost Thromb. 2003;33(3):127–133. doi:10.1159/000077820
   PubMedGoogle Scholar
• Bennett PN. Effect of physical exercise on platelet adhesiveness. Scand J Haematol. 1972;9(2):138–141.
   PubMedGoogle Scholar
• Li N, Wallén NH, Hjemdahl P. Evidence for prothrombotic effects of exercise and limited protection by aspirin. Circulation. 1999;100(13):1374–1379.
   PubMed Web of Science ®Google Scholar
• Möckel M, Ulrich NV, Röcker L, Ruf A, Klefisch F, Patscheke H, Eichstädt H, Störk T, Frei U. Exhaustive cycle exercise induces P-selectin expression, coagulation, and fibrinolysis activation in ultraendurance athletes. Thromb Res. 1999;94(4):263–269.
   PubMed Web of Science ®Google Scholar
• Zaleski A, Capizzi J, Ballard KD, Troyanos C, Baggish A, D’Hemecourt P, Thompson PD, Parker B. Statins attenuate the increase in P-selectin produced by prolonged exercise. J Sports Med (Hindawi Publ Corp). 2013;2013:487567.
   PubMedGoogle Scholar
• Röcker L, Günay S, Gunga HC, Hopfenmüller W, Ruf A, Patscheke H, Möckel M. Activation of blood platelets in response to maximal isometric exercise of the dominant arm. Int J Sports Med. 2000;21(3):191–194. doi:10.1055/s-2000-303
   PubMed Web of Science ®Google Scholar
• Perneby C, Wallén NH, Hu H, Li N, Hjemdahl P. Prothrombotic responses to exercise are little influenced by clopidogrel treatment. Thromb Res. 2004;114(4):235–243. doi:10.1016/j.thromres.2004.06.004
   PubMed Web of Science ®Google Scholar
• Peat EE, Dawson M, McKenzie A, Hillis WS. The effects of acute dynamic exercise on haemostasis in first class Scottish football referees. Br J Sports Med. 2010;44(8):573–578. doi:10.1136/bjsm.2008.053306
   PubMed Web of Science ®Google Scholar
• Hilberg T, Menzel K, Gläser D, Zimmermann S, Gabriel HHW. Exercise intensity: platelet function and platelet-leukocyte conjugate formation in untrained subjects. Thromb Res. 2008;122(1):77–84. doi:10.1016/j.thromres.2007.08.018
   PubMed Web of Science ®Google Scholar
• Wang JS, Liao CH. Moderate-intensity exercise suppresses platelet activation and polymorphonuclear leukocyte interaction with surface-adherent platelets under shear flow in men. Thromb Haemost. 2004;91(3):587–594. doi:10.1160/TH03-10-0644
   PubMed Web of Science ®Google Scholar
• Wang JS. Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein IIb/IIIa activation, and p-selectin expression on platelets. Eur J Appl Physiol. 2004;91(5–6):741–747. doi:10.1007/s00421-004-1050-4
   PubMed Web of Science ®Google Scholar
• Coppola A, Coppola L, Dalla Mora L, Limongelli FM, Grassia A, Mastrolorenzo L, Gombos G, Lucivero G. Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression. J Appl Physiol (1985). 2005;98(4):1414–1419. doi:10.1152/japplphysiol.00315.2004
   PubMed Web of Science ®Google Scholar
• Stratton JR, Malpass TW, Ritchie JL, Pfeifer MA, Harker LA. Studies of platelet factor 4 and beta thromboglobulin release during exercise: lack of relationship to myocardial ischemia. Circulation. 1982;66(1):33–43.
   PubMed Web of Science ®Google Scholar
• Pechán J, Okrucká A, Marček T. Effect of acute exercise on plasma beta‐thromboglobulin and platelet aggregation in young athletes. Sports Med Training Rehabil. 1991;2:77–84. doi:10.1080/15438629109511902
   Google Scholar
• Röcker L, Drygas WK, Heyduck B. Blood platelet activation and increase in thrombin activity following a marathon race. Eur J Appl Physiol Occup Physiol. 1986;55(4):374–380.
   PubMed Web of Science ®Google Scholar
• Ahmadizad S, el-Sayed MS. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc. 2003;35(6):1026–1032. doi:10.1249/01.MSS.0000069406.54766.C6
   PubMed Web of Science ®Google Scholar
• Knudsen JB, Brodthagen U, Gormsen J, Jordal R, Nørregaard-Hansen K, Paulev PE. Platelet function and fibrinolytic activity following distance running. Scand J Haematol. 1982;29(5):425–430.
   PubMedGoogle Scholar
• Drygas WK. Changes in blood platelet function, coagulation, and fibrinolytic activity in response to moderate, exhaustive, and prolonged exercise. Int J Sports Med. 1988;9(1):67–72. doi:10.1055/s-2007-1024981
   PubMed Web of Science ®Google Scholar
• Davis RB, Boyd DG, McKinney ME, Jones CC. Effects of exercise and exercise conditioning on blood platelet function. Med Sci Sports Exerc. 1990;22(1):49–53.
   PubMed Web of Science ®Google Scholar
• Weber AA, Heim HK, Schumacher M, Schrör K, Hohlfeld T. Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. Platelets. 2007;18(5):379–385. doi:10.1080/09537100601115919
   PubMed Web of Science ®Google Scholar
• Ersöz G, Zergeroglu AM, Fiçicilar H, Ozcan H, Oztekin P, Aytaç S, Yavuzer S. Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. Thromb Res. 2002;108(5–6):297–301.
   PubMed Web of Science ®Google Scholar
• Ersöz G, Zergeroğlu AM, Yakaryilmaz A. The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. Thromb Res. 2002;108(2–3):147–150.
   PubMed Web of Science ®Google Scholar
• Hsu HC, Lee YT, Chen MF. Exercise shifts the platelet aggregation modulatory role from native to mildly oxidized low-density lipoprotein. Med Sci Sports Exerc. 2000;32(5):933–939.
   PubMed Web of Science ®Google Scholar
• Ronni-Sivula H, Malm H, Ylikorkala O, Viinikka L. Marathon run stimulates more prostacyclin than thromboxane synthesis and differently in men and women. Prostaglandins. 1993;46(1):75–79.
   PubMedGoogle Scholar
• Chaar V, Romana M, Tripette J, Broquere C, Huisse MG, Hue O, Hardy-Dessources MD, Connes P. Effect of strenuous physical exercise on circulating cell-derived microparticles. Clin Hemorheol Microcirc. 2011;47(1):15–25. doi:10.3233/CH-2010-1361
   PubMed Web of Science ®Google Scholar
• Sossdorf M, Otto GP, Claus RA, Gabriel HH, Lösche W. Cell-derived microparticles promote coagulation after moderate exercise. Med Sci Sports Exerc. 2011;43(7):1169–1176. doi:10.1249/MSS.0b013e3182068645
   PubMed Web of Science ®Google Scholar
• Nieuwland R, Berckmans RJ, Rotteveel-Eijkman RC, Maquelin KN, Roozendaal KJ, Jansen PG, Ten Have K, Eijsman L, Hack CE, Sturk A. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation. 1997;96(10):3534–3541.
   PubMed Web of Science ®Google Scholar
• Möckel M, Ulrich NV, Heller G Jr, Röcker L, Hansen R, Riess H, Patscheke H, Störk T, Frei U, Ruf A. Platelet activation through triathlon competition in ultra-endurance trained athletes: impact of thrombin and plasmin generation and catecholamine release. Int J Sports Med. 2001;22(5):337–343. doi:10.1055/s-2001-15649
   PubMed Web of Science ®Google Scholar
• Hilberg T, Glä D, Schmidt V, Lösche W, Franke G, Schneider K, Gabriel HH. Short-term exercise and platelet activity, sensitivity to agonist, and platelet-leukocyte conjugate formation. Platelets. 2003;14(2):67–74. doi:10.1080/0953710021000057541
   PubMed Web of Science ®Google Scholar
• Hilberg T, Gläser D, Koksch M, Schmidt V, Sossdorf M, Gabriel HH. Differentiation of platelet-leukocyte conjugate formation by short term exercise. Clin Hemorheol Microcirc. 2004;31(3):217–226.
   PubMed Web of Science ®Google Scholar
• Hilberg T, Schmidt V, Gläser D, Schammne D, Lösche W, Gabriel HH. Platelet activity, sensitivity to agonist, and platelet–leukocyte conjugate formation after long-term exercise. Platelets. 2002;13(5–6):273–277. doi:10.1080/0953770021000007249
   PubMed Web of Science ®Google Scholar
• Aldemir H, Kiliç N. The effect of time of day and exercise on platelet functions and platelet-neutrophil aggregates in healthy male subjects. Mol Cell Biochem. 2005;280(1–2):119–124. doi:10.1007/s11010-005-8238-8
   PubMed Web of Science ®Google Scholar
• Shantsila E, Tapp LD, Wrigley BJ, Montoro-Garcia S, Ghattas A, Jaipersad A, Lip GY. The effects of exercise and diurnal variation on monocyte subsets and monocyte-platelet aggregates. Eur J Clin Invest. 2012;42(8):832–839. doi:10.1111/j.1365-2362.2012.02656.x
   PubMed Web of Science ®Google Scholar
• Dimitriadou C, Dessypris A, Louizou C, Mandalaki T. Marathon run II: effects on platelet aggregation. Thromb Haemost. 1977;37(3):451–455.
   PubMed Web of Science ®Google Scholar
• Small M, Tweddel AC, Rankin AC, Lowe GDO, Prentice CRM, Forbes CD. Blood coagulation and platelet function following maximal exercise: Effects of beta-adrenoceptor blockade. Haemostasis. 1984;14:262–268. doi:10.1159/000215067
   PubMedGoogle Scholar
• Dag B, Gleerup G, Bak AM, Hindberg I, Mehlsen J, Winther K. Effect of supine exercise on platelet aggregation and fibrinolytic activity. Clin Physiol. 1994;14(2):181–186.
   PubMedGoogle Scholar
• Tozzi-Ciancarelli MG, Penco M, Di Massimo C. Influence of acute exercise on human platelet responsiveness: possible involvement of exercise-induced oxidative stress. Eur J Appl Physiol. 2002;86(3):266–272.
   PubMed Web of Science ®Google Scholar
• Mandalaki T, Dessypris A, Louizou C, Panayotopoulou C, Dimitriadou C. Marathon Run III: effects on coagulation, fibrinolysis, platelet aggregation and serum cortisol levels. A 3-year study. Thromb Haemost. 1980;43(1):49–52.
   PubMed Web of Science ®Google Scholar
• Kratz A, Wood MJ, Siegel AJ, Hiers JR, Van Cott EM. Effects of marathon running on platelet activation markers: direct evidence for in vivo platelet activation. Am J Clin Pathol. 2006;125(2):296–300. doi:10.1309/PRF5-N7P2-XM6E-243H
   PubMed Web of Science ®Google Scholar
• Chapman ES, Sorette M, Hetherington E, Zelmanovic D, Kling G, Dugailliez J, Pujol-Moix N, Okrongly D. A rapid, automated flow cytometric method to measure activated degranulated platelets by density determination. Thromb Haemost. 2003;89(6):1004–1015.
   PubMed Web of Science ®Google Scholar
• Giacomini A, Legovini P, Antico F, Valverde S, Salvadego MM, Manoni F, Gessoni G. Assessment of in vitro platelet activation by Advia 120 platelet parameters. Lab Hematol. 2003;9(3):132–137.
   PubMedGoogle Scholar
• Rock G, Tittley P, Pipe A. Coagulation factor changes following endurance exercise. Clin J Sport Med. 1997;7(2):94–99.
   PubMed Web of Science ®Google Scholar
• Singh I, Quinn H, Mok M, Southgate RJ, Turner AH, Li D, Sinclair AJ, Hawley JA. The effect of exercise and training status on platelet activation: do cocoa polyphenols play a role?. Platelets. 2006;17(6):361–367. doi:10.1080/09537100600746953
   PubMed Web of Science ®Google Scholar
• Chicharro JL, Sánchez O, Bandrés F, Guantes Y, Yges A, Lucía A, Legido JC. Platelet aggregability in relation to the anaerobic threshold. Thromb Res. 1994;75(3):251–257.
   PubMed Web of Science ®Google Scholar
• Kupchak BR, Kazman JB, Vingren JL, Levitt DE, Lee EC, Williamson KH, Armstrong LE, Deuster PA. Blood hemostatic changes during an ultraendurance road cycling event in a hot environment. Wilderness Environ Med. 2017;28(3):197–206. doi:10.1016/j.wem.2017.05.002
   PubMed Web of Science ®Google Scholar
• Kim J-H, Wu T, Roberge R, Coca A. Hyperthermia exaggerates exercise-induced aggregation of blood platelets. Extrem Physiol Med. 2015;4(Suppl 1):A153. doi:10.1186/2046-7648-4-S1-A153
   Google Scholar
• Bakovic D, Pivac N, Eterovic D, Palada I, Valic Z, Paukovic-Sekulic B, Dujic Z. Changes in platelet size and spleen volume in response to selective and non-selective beta-adrenoceptor blockade in hypertensive patients. Clin Exp Pharmacol Physiol. 2009;36(4):441–446. doi:10.1111/j.1440-1681.2008.05090.x
   PubMed Web of Science ®Google Scholar
• Lande K, Os I, Kjeldsen SE, Westheim A, Aakesson I, Hjermann I, Eide I, Gjesdal K. Platelet volume, platelet release reaction and platelet response to infused adrenaline are increased in essential hypertension. Acta Med Scand Suppl. 1986;714:129–132.
   PubMedGoogle Scholar
• Brodde OE, Stuka N, Demuth V, Fesel R, Bergerhausen J, Daul A, Bock KD. Alpha- and beta-adrenoceptors in circulating blood cells of essential hypertensive patients: increased receptor density and responsiveness. Clin Exp Hypertens A. 1985;7(8):1135–1150.
   PubMed Web of Science ®Google Scholar
• Andrioli G, Ortolani R, Fontana L, Gaino S, Bellavite P, Lechi C, Minuz P, Manzato F, Tridente G, Lechi A. Study of platelet adhesion in patients with uncomplicated hypertension. J Hypertens. 1996;14(10):1215–1221.
   PubMed Web of Science ®Google Scholar
• Markel A, Brook JG, Levy Y, Aviram M, Youdim MB. Increased platelet adhesion and aggregation in hypertensive patients: effect of atenolol. Br J Clin Pharmacol. 1983;16(6):663–668.
   PubMed Web of Science ®Google Scholar
• Brook JG, Marmur A, Berkovitch Y, Aviram M. Platelet adhesion in hyperlipidemic and hypertensive patients. Haemostasis. 1985;15(6):371–376. doi:10.1159/000215175
   PubMedGoogle Scholar
• Mehrotra TN, Mehrotra R. Platelet adhesiveness, plasma fibrinogen and fibrinolytic activity in cases of essential hypertension. J Postgrad Med. 1987;33:178–181.
   PubMedGoogle Scholar
• Kasuya N, Kishi Y, Sakita SY, Numano F, Isobe M. Acute vigorous exercise primes enhanced NO release in human platelets. Atherosclerosis. 2002;161(1):225–232.
   PubMed Web of Science ®Google Scholar
• Camilletti A, Moretti N, Giacchetti G, Faloia E, Martarelli D, Mantero F, Mazzanti L. Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients. Am J Hypertens. 2001;14(4 Pt 1):382–386.
   PubMed Web of Science ®Google Scholar
• Torres-Guerra E, Diez-Ewald M, Vizcaíno G, Arteaga-Vizcaíno M, Sulbarán T. Effect of stress electrocardiogram on platelet function, concentration of von Willebrand factor and fibrinogen in hypertensive patients and healthy subjects. Invest Clin. 2000;41(2):105–116.
   PubMedGoogle Scholar
• Schwieler JH, Kahan T, Wallén NH, Nussberger J, Hjemdahl P. Inhibition of the renin-angiotensin system does not reduce platelet activity at rest or during stress in hypertension. J Hypertens. 2013;31(8):1676–1682. doi:10.1097/HJH.0b013e3283617310
   PubMed Web of Science ®Google Scholar
• Lemne C, Vesterqvist O, Egberg N, Green K, Jogestrand T, de Faire U. Platelet activation and prostacyclin release in essential hypertension. Prostaglandins. 1992;44(3):219–235.
   PubMed Web of Science ®Google Scholar
• Lekakis J, Triantafyllidi H, Galea V, Koutroumbi M, Theodoridis T, Komporozos C, Ikonomidis I, Christopoulou-Cokkinou V, Kremastinos DT. The immediate effect of aerobic exercise on haemostatic parameters in patients with recently diagnosed mild to moderate essential hypertension. J Thromb Thrombolysis. 2008;25(2):179–184. doi:10.1007/s11239-007-0058-0
   PubMed Web of Science ®Google Scholar
• Hvas AM, Grove EL. Platelet function tests: preanalytical variables, clinical utility, advantages, and disadvantages. Methods Mol Biol. 2017;1646:305–320. doi:10.1007/978-1-4939-7196-1_24
   PubMedGoogle Scholar
• Krekels JPM, Verhezen PWM, Henskens YMC. Platelet aggregation in healthy participants is not affected by smoking, drinking coffee, consuming a high-fat meal, or performing physical exercise. Clin Appl Thromb Hemost. 2019;25:1076029618782445. doi:10.1177/1076029618782445
   Web of Science ®Google Scholar
• Vlachakis ND, Aledort L. Hypertension and propranolol therapy: effect on blood pressure, plasma catecholamines and platelet aggregation. Am J Cardiol. 1980;45(2):321–325.
   PubMed Web of Science ®Google Scholar
• Rankinen T, Väisänen S, Penttilä I, Rauramaa R. Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost. 1995;73(2):281–286.
   PubMed Web of Science ®Google Scholar
• Kestin AS, Ellis PA, Barnard MR, Errichetti A, Rosner BA, Michelson AD. Effect of strenuous exercise on platelet activation state and reactivity. Circulation. 1993;88(4 Pt 1):1502–1511.
   PubMed Web of Science ®Google Scholar
• Svensson J, Hamberg M, Samuelsson B. On the formation and effects of thromboxane A2 in human platelets. Acta Physiol Scand. 1976;98(3):285–294. doi:10.1111/j.1748-1716.1976.tb10313.x
   PubMedGoogle Scholar
• Catella F, FitzGerald GA. Paired analysis of urinary thromboxane B2 metabolites in humans. Thromb Res. 1987;47(6):647–656.
   PubMed Web of Science ®Google Scholar
• Siminiak T, Egdell RM, O’Gorman DJ, Dye JF, Sheridan DJ. Plasma-mediated neutrophil activation during acute myocardial infarction: role of platelet-activating factor. Clin Sci (Lond). 1995;89(2):171–176.
   PubMed Web of Science ®Google Scholar
• Magagna A, Abdel-Haq B, Favilla S, Taddei S, Salvetti A. Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients. Blood Press. 1994;3(4):236–241.
   PubMedGoogle Scholar
• Taylor ML, Misso NL, Stewart GA, Thompson PJ. The effects of varying doses of aspirin on human platelet activation induced by PAF, collagen and arachidonic acid. Br J Clin Pharmacol. 1992;33(1):25–31.
   PubMed Web of Science ®Google Scholar
• Jootar S, Chaisiripoomkere W, Thaikla O, Kaewborworn M. Effect of running exercise on hematological changes, hematopoietic progenitor cells (CFU-GM) and fibrinolytic system in humans. J Med Assoc Thai. 1992;75(2):94–98.
   PubMedGoogle Scholar
• Prisco D, Paniccia R, Bandinelli B, Fedi S, Cellai AP, Liotta AA, Gatteschi L, Giusti B, Colella A, Abbate R, et al. Evaluation of clotting and fibrinolytic activation after protracted physical exercise. Thromb Res. 1998;89(2):73–78.
   PubMed Web of Science ®Google Scholar
• Osterud B, Olsen JO, Wilsgård L. Effect of strenuous exercise on blood monocytes and their relation to coagulation. Med Sci Sport Exer. 1989;21(4):374–378.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS. Fibrinogen levels and exercise. Is there a relationship? Sports Med 1996;21(6):402–408. doi:10.2165/00007256-199621060-00002
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Jones PG, Sale C. Exercise induces a change in plasma fibrinogen concentration: fact or fiction?. Thromb Res. 1999;96(6):467–472.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Davies B. A physical conditioning program does not alter fibrinogen concentration in young healthy subjects. Med Sci Sport Exer. 1995;27(4):485–489. doi:10.1249/00005768-199504000-00004
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Davies B, Morgan DB. Vasopressin and plasma volume response to submaximal and maximal exercise in man. J Sports Med Phys Fitness. 1990;30(4):420–425.
   PubMed Web of Science ®Google Scholar
• Montgomery HE, Clarkson P, Nwose OM, Mikailidis DP, Jagroop IA, Dollery C, Moult J, Benhizia F, Deanfield J, Jubb M, et al. The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene. Arterioscler Thromb Vasc Biol. 1996;16(3):386–391.
   PubMed Web of Science ®Google Scholar
• Siegel AJ, Stec JJ, Lipinska I, Van Cott EM, Lewandrowski KB, Ridker PM, Tofler GH. Effect of marathon running on inflammatory and hemostatic markers. Am J Cardiol. 2001;88(8):918–20,A9.
   PubMed Web of Science ®Google Scholar
• van der Bom JG, de Maat MP, Bots ML, Hofman A, Kluft C, Grobbee DE. Seasonal variation in fibrinogen in the Rotterdam Study. Thromb Haemost. 1997;78(3):1059–1062.
   PubMed Web of Science ®Google Scholar
• Bremner WF, Sothern RB, Kanabrocki EL, Ryan M, McCormick JB, Dawson S, Connors ES, Rothschild R, Third JL, Vahed S, et al. Relation between circadian patterns in levels of circulating lipoprotein(a), fibrinogen, platelets, and related lipid variables in men. Am Heart J. 2000 Jan;139(1 Pt 1):164–173.
   PubMed Web of Science ®Google Scholar
• Humphries SE, Ye S, Talmud P, Bara L, Wilhelmsen L, Tiret L. European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene) is associated with differences in plasma fibrinogen levels in young men and women from different regions in Europe. Evidence for gender-genotype-environment interaction. Arterioscler Thromb Vasc Biol. 1995;15(1):96–104.
   PubMed Web of Science ®Google Scholar
• Davis J, Murphy M, Trinick T, Duly E, Nevill A, Davison G. Acute effects of walking on inflammatory and cardiovascular risk in sedentary post-menopausal women. J Sports Sci. 2008;26(3):303–309. doi:10.1080/02640410701552906
   PubMed Web of Science ®Google Scholar
• Plaisance EP, Taylor JK, Alhassan S, Abebe A, Mestek ML, Grandjean PW. Cardiovascular fitness and vascular inflammatory markers after acute aerobic exercise. Int J Sport Nutr Exerc Metab. 2007;17(2):152–162.
   PubMed Web of Science ®Google Scholar
• Cerneca E, Simeone R, Bruno G, Gombacci A. Coagulation parameters in senior athletes practicing endurance sporting activity. J Sports Med Phys Fitness. 2005;45(4):576–579.
   PubMed Web of Science ®Google Scholar
• Smith JE, Garbutt G, Lopes P, Tunstall Pedoe D. Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. Br J Sports Med. 2004;38(3):292–294. doi:10.1136/bjsm.2002.002873
   PubMed Web of Science ®Google Scholar
• Collen D, Semeraro N, Tricot JP, Vermylen J. Turnover of fibrinogen, plasminogen, and prothrombin during exercise in man. J Appl Physiol Respir Environ Exerc Physiol. 1977;42(6):865–873. doi:10.1152/jappl.1977.42.6.865
   PubMed Web of Science ®Google Scholar
• Sand KL, Flatebo T, Andersen MB, Maghazachi AA. Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males. World J Exp Med. 2013;3(1):11–20. doi:10.5493/wjem.v3.i1.11
   PubMedGoogle Scholar
• Iatridis SG, Ferguson JH. Effect of physical exercise on blood clotting and fibrinolysis. J Appl Physiol. 1963;18:337–344. doi:10.1152/jappl.1963.18.2.337
   PubMed Web of Science ®Google Scholar
• Marsh NA, Gaffney PJ. Exercise-induced fibrinolysis–fact or fiction? Thromb Haemost. 1982;48(2):201–203.
   PubMed Web of Science ®Google Scholar
• Hilberg T, Prasa D, Stürzebecher J, Gläser D, Gabriel HH. Thrombin potential and thrombin generation after exhaustive exercise. Int J Sports Med. 2002;23(7):500–504. doi:10.1055/s-2002-35123
   PubMed Web of Science ®Google Scholar
• Lippi G, Salvagno GL, Tarperi C, Gelati M, Montagnana M, Danese E, Festa L, Sanchis-Gomar F, Favaloro EJ, Schena F. Prothrombotic state induced by middle-distance endurance exercise in middle-aged athletes. Semin Thromb Hemost. 2018;44(8):747–755. doi:10.1055/s-0038-1667115
   PubMed Web of Science ®Google Scholar
• Andrew M, Carter C, O’Brodovich H, Heigenhauser G. Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity. J Appl Physiol (1985). 1986;60(6):1917–1922. doi:10.1152/jappl.1986.60.6.1917
   PubMed Web of Science ®Google Scholar
• Menzel K, Hilberg T. Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011;111(2):253–260. doi:10.1007/s00421-010-1640-2
   PubMed Web of Science ®Google Scholar
• Ferguson EW, Bernier LL, Banta GR, Yu-Yahiro J, Schoomaker EB. Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J Appl Physiol (1985). 1987;62(4):1416–1421. doi:10.1152/jappl.1987.62.4.1416
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Lin X, Rattu AJ. Blood coagulation and fibrinolysis at rest and in response to maximal exercise before and after a physical conditioning programme. Blood Coagul Fibrinolysis. 1995;6(8):747–752.
   PubMed Web of Science ®Google Scholar
• Hansen JB, Wilsgård L, Olsen JO, Osterud B. Formation and persistence of procoagulant and fibrinolytic activities in circulation after strenuous physical exercise. Thromb Haemost. 1990;64(3):385–389.
   PubMed Web of Science ®Google Scholar
• Hegde SS, Goldfarb AH, Hegde S. Clotting and fibrinolytic activity change during the 1 h after a submaximal run. Med Sci Sports Exerc. 2001;33(6):887–892.
   PubMed Web of Science ®Google Scholar
• van Den Burg PJ, Hospers JE, van Vliet M, Mosterd WL, Huisveld IA. Unbalanced haemostatic changes following strenuous physical exercise. A study in young sedentary males. Eur Heart J. 1995;16(12):1995–2001.
   PubMed Web of Science ®Google Scholar
• Connelly JB, Cooper JA, Meade TW. Strenuous exercise, plasma fibrinogen, and factor VII activity. Br Heart J. 1992;67(5):351–354. doi:10.1136/hrt.67.5.351
   PubMedGoogle Scholar
• Przybyłowski J, Hajduk A, Słomba M, Obodyński K. The effect of progressive incremental exercise on some parameters of hemostasis. Wiad Lek. 1998;51(5–6):260–264.
   PubMedGoogle Scholar
• Hansen JB, Olsen JO, Osterud B. Physical exercise enhances plasma levels of extrinsic pathway inhibitor (EPI). Thromb Haemost. 1990;64(1):124–126.
   PubMed Web of Science ®Google Scholar
• Sechi LA, Zingaro L, Catena C, Casaccio D, De Marchi S. Relationship of fibrinogen levels and hemostatic abnormalities with organ damage in hypertension. Hypertension. 2000;36(6):978–985.
   PubMed Web of Science ®Google Scholar
• Letcher RL, Chien S, Pickering TG, Sealey JE, Laragh JH. Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects. Role of fibrinogen and concentration. Am J Med. 1981;70(6):1195–1202.
   PubMed Web of Science ®Google Scholar
• Patrassi GM, Fallo F, Santarossa A, Sartori MT, Casonato A, Girolami A. Clotting changes in borderline hypertension. J Hum Hypertens. 1987;1(2):101–103.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Sale C, Jones PG, Chester M. Blood hemostasis in exercise and training. Med Sci Sports Exerc. 2000;32(5):918–925.
   PubMed Web of Science ®Google Scholar
• Smith JE. Effects of strenuous exercise on haemostasis. Br J Sports Med. 2003;37(5):433–435. doi:10.1136/bjsm.37.5.433
   PubMed Web of Science ®Google Scholar
• Weiss C, Seitel G, Bärtsch P. Coagulation and fibrinolysis after moderate and very heavy exercise in healthy male subjects. Med Sci Sports Exerc. 1998;30(2):246–251.
   PubMed Web of Science ®Google Scholar
• Hilberg T, Prasa D, Stürzebecher J, Gläser D, Schneider K, Gabriel HH. Blood coagulation and fibrinolysis after extreme short-term exercise. Thromb Res. 2003;109(5–6):271–277.
   PubMed Web of Science ®Google Scholar
• Sedgwick MJ, Thompson M, Garnham J, Thackray AE, Barrett LA, Powis M, Stensel DJ. Acute high-intensity interval rowing increases thrombin generation in healthy men. Eur J Appl Physiol. 2016;116(6):1139–1148. doi:10.1007/s00421-016-3370-6
   PubMed Web of Science ®Google Scholar
• Hemker HC, de Smedt E, Al Dieri R. The contribution of alpha(2)-macroglobulin thrombin to the endogenous thrombin potential. Br J Haematol. 2007;139(3):513. doi:10.1111/j.1365-2141.2007.06837.x
   PubMed Web of Science ®Google Scholar
• Hilberg T, Gläser D, Prasa D, Stürzebecher J, Gabriel HH. Pure eccentric exercise does not activate blood coagulation. Eur J Appl Physiol. 2005;94(5–6):718–721. doi:10.1007/s00421-005-1353-0
   PubMed Web of Science ®Google Scholar
• Herren T, Bärtsch P, Haeberli A, Straub PW. Increased thrombin-antithrombin III complexes after 1 h of physical exercise. J Appl Physiol (1985). 1992;73(6):2499–2504. doi:10.1152/jappl.1992.73.6.2499
   PubMed Web of Science ®Google Scholar
• Kupchak BR, Volk BM, Kunces LJ, Kraemer WJ, Hoffman MD, Phinney SD, Volek JS. Alterations in coagulatory and fibrinolytic systems following an ultra-marathon. Eur J Appl Physiol. 2013;113(11):2705–2712. doi:10.1007/s00421-013-2709-5
   PubMed Web of Science ®Google Scholar
• Sumann G, Fries D, Griesmacher A, Falkensammer G, Klingler A, Koller A, Streif W, Greie S, Schobersberger B, Schobersberger W. Blood coagulation activation and fibrinolysis during a downhill marathon run. Blood Coagul Fibrinolysis. 2007;18(5):435–440. doi:10.1097/MBC.0b013e328136c19b
   PubMed Web of Science ®Google Scholar
• van Den Burg PJ, Hospers JE, van Vliet M, Mosterd WL, Bouma BN, Huisveld IA. Changes in haemostatic factors and activation products after exercise in healthy subjects with different ages. Thromb Haemost. 1995;74(6):1457–1464.
   PubMed Web of Science ®Google Scholar
• Menzel K, Hilberg T. Coagulation and fibrinolysis are in balance after moderate exercise in middle-aged participants. Clin Appl Thromb Hemost. 2009;15(3):348–355. doi:10.1177/1076029608326306
   PubMed Web of Science ®Google Scholar
• Dufaux B, Order U, Liesen H. Effect of a short maximal physical exercise on coagulation, fibrinolysis, and complement system. Int J Sports Med. 1991 Jun;12(Suppl 1):S38–S42. doi:10.1055/s-2007-1024748
   PubMedGoogle Scholar
• Bärtsch P, Schmidt EK, Straub PW. Fibrinopeptide A after strenuous physical exercise at high altitude. J Appl Physiol Respir Environ Exerc Physiol. 1982;53(1):40–43. doi:10.1152/jappl.1982.53.1.40
   PubMed Web of Science ®Google Scholar
• Wallén NH, Goodall AH, Li N, Hjemdahl P. Activation of haemostasis by exercise, mental stress and adrenaline: effects on platelet sensitivity to thrombin and thrombin generation. Clin Sci (Lond). 1999;97(1):27–35.
   PubMed Web of Science ®Google Scholar
• Hamulyák K, Brommer E, Dévilée P, Hemker H. Activation of coagulation and fibrinolysis during maximal physical exercise. Int J Sports Med. 1984;5:64–65. doi:10.1055/s-2008-1025953
   Google Scholar
• Hyers TM, Martin BJ, Pratt DS, Dreisin RB, Franks JJ. Enhanced thrombin and plasmin activity with exercise in man. J Appl Physiol Respir Environ Exerc Physiol. 1980;48(5):821–825. doi:10.1152/jappl.1980.48.5.821
   PubMed Web of Science ®Google Scholar
• Weiss C, Welsch B, Albert M, Friedmann B, Strobel G, Jost J, Nawroth P, Bärtsch P. Coagulation and thrombomodulin in response to exercise of different type and duration. Med Sci Sports Exerc. 1998;30(8):1205–1210.
   PubMed Web of Science ®Google Scholar
• Bärtsch P, Welsch B, Albert M, Friedmann B, Levi M, Kruithof EK. Balanced activation of coagulation and fibrinolysis after a 2-h triathlon. Med Sci Sports Exerc. 1995;27(11):1465–1470.
   PubMed Web of Science ®Google Scholar
• Röcker L, Taenzer M, Drygas WK, Lill H, Heyduck B, Altenkirch HU. Effect of prolonged physical exercise on the fibrinolytic system. Eur J Appl Physiol Occup Physiol. 1990;60(6):478–481.
   PubMed Web of Science ®Google Scholar
• Kahraman S, Bediz CS, Pişkin O, Aksu I, Topçu A, Yüksel F, Demirkan F. The effect of the acute submaximal exercise on thrombin activatable fibrinolysis inhibitor levels in young sedentary males. Clin Appl Thromb Hemost. 2011;17(4):414–420. doi:10.1177/1076029610385672
   PubMed Web of Science ®Google Scholar
• Vind J, Gleerup G, Nielsen PT, Winther K. The impact of static work on fibrinolysis and platelet function. Thromb Res. 1993;72(5):441–446.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS. Exercise intensity-related responses of fibrinolytic activity and vasopressin in man. Med Sci Sports Exerc. 1990;22(4):494–500.
   PubMed Web of Science ®Google Scholar
• Cooper JA, Nagelkirk PR, Coughlin AM, Pivarnik JM, Womack CJ. Temporal changes in tPA and PAI-1 after maximal exercise. Med Sci Sports Exerc. 2004;36(11):1884–1887.
   PubMed Web of Science ®Google Scholar
• Baynard T, Jacobs HM, Kessler CM, Kanaley JA, Fernhall B. Fibrinolytic markers and vasodilatory capacity following acute exercise among men of differing training status. Eur J Appl Physiol. 2007;101(5):595–602. doi:10.1007/s00421-007-0534-4
   PubMed Web of Science ®Google Scholar
• Hilberg T, Gläser D, Reckhart C, Prasa D, Stürzebecher J, Gabriel HH. Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold. Eur J Appl Physiol. 2003;90(5–6):639–642. doi:10.1007/s00421-003-0907-2
   PubMed Web of Science ®Google Scholar
• Womack CJ, Rasmussen JM, Vickers DG, Paton CM, Osmond PJ, Davis GL. Changes in fibrinolysis following exercise above and below lactate threshold. Thromb Res. 2006;118(2):263–268. doi:10.1016/j.thromres.2005.06.016
   PubMed Web of Science ®Google Scholar
• DeSouza CA, Dengel DR, Rogers MA, Cox K, Macko RF. Fibrinolytic responses to acute physical activity in older hypertensive men. J Appl Physiol (1985). 1997;82(6):1765–1770. doi:10.1152/jappl.1997.82.6.1765
   PubMed Web of Science ®Google Scholar
• Smith DL, Horn GP, Petruzzello SJ, Fahey G, Woods J, Fernhall B. Clotting and fibrinolytic changes after firefighting activities. Med Sci Sports Exerc. 2014;46(3):448–454. doi:10.1249/MSS.0b013e3182a76dd2
   PubMed Web of Science ®Google Scholar
• Szymanski LM, Pate RR. Effects of exercise intensity, duration, and time of day on fibrinolytic activity in physically active men. Med Sci Sports Exerc. 1994;26(9):1102–1108.
   PubMed Web of Science ®Google Scholar
• Szymanski LM, Pate RR, Durstine JL. Effects of maximal exercise and venous occlusion on fibrinolytic activity in physically active and inactive men. J Appl Physiol (1985). 1994;77(5):2305–2310. doi:10.1152/jappl.1994.77.5.2305
   PubMed Web of Science ®Google Scholar
• Huskens D, Roest M, Remijn JA, Konings J, Kremers RM, Bloemen S, Schurgers E, Selmeczi A, Kelchtermans H, van Meel R, et al. Strenuous exercise induces a hyperreactive rebalanced haemostatic state that is more pronounced in men. Thromb Haemost. 2016;115(6):1109–1119. doi:10.1160/TH15-10-0821
   PubMed Web of Science ®Google Scholar
• Zadow EK, Kitic CM, Wu SSX, Fell JW, Adams MJ. Time of day and short-duration high-intensity exercise influences on coagulation and fibrinolysis. Eur J Sport Sci. 2018;18(3):367–375. doi:10.1080/17461391.2017.1420237
   PubMed Web of Science ®Google Scholar
• Amini A, Sobhani V, Mohammadi MT, Shirvani H. Acute effects of aerobic, resistance and concurrent exercises, and maximal shuttle run test on coagulation and fibrinolytic activity in healthy young non-athletes. J Sports Med Phys Fitness. 2017;57(5):633–642. doi:10.23736/S0022-4707.16.06092-8
   PubMed Web of Science ®Google Scholar
• Kupchak BR, Kraemer WJ, Hooper DR, Saenz C, Dulkis LL, Secola PJ, Brown LE, Galpin AJ, Coburn JW, DuPont WH, et al. The effects of a transcontinental flight on markers of coagulation and fibrinolysis in healthy men after vigorous physical activity. Chronobiol Int. 2017;34(2):148–161. doi:10.1080/07420528.2016.1247851
   PubMed Web of Science ®Google Scholar
• Małyszko J, Tymcio J. Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with essential arterial hypertension. Pol Arch Med Wewn. 2008;118(1–2):36–41.
   PubMedGoogle Scholar
• Kłoczko J, Wojtukiewicz MZ, Galar M, Tarasów E, Jaromin J, Bielawiec M. Prothrombin activation fragment 1 + 2 and thrombin-antithrombin-III complexes in plasma of patients with essential arterial hypertension. Pol J Pharmacol. 1996;48(2):233–235.
   PubMedGoogle Scholar
• Trifiletti A, Scamardi R, Pizzoleo MA, Sottilotta G, Barbera N, Frisina N. Increased indexes of thrombin activation in advanced stages of hypertension. Haemostasis. 2001;31(1):49–54. doi:10.1159/000048044
   PubMedGoogle Scholar
• Jeng JR, Sheu WH, Jeng CY, Huang SH, Shieh SM. Impaired fibrinolysis and insulin resistance in patients with hypertension. Am J Hypertens. 1996;9(5):484–490.
   PubMed Web of Science ®Google Scholar
• Galea V, Triantafyllidi H, Theodoridis T, Koutroumbi M, Christopoulou-Cokkinou V, Kremastinos D, Anastasiou-Nana M, Lekakis J. Long-term treatment with ramipril favourably modifies the haemostatic response to acute submaximal exercise in hypertensives. J Renin Angiotensin Aldosterone Syst. 2013;14(4):322–329. doi:10.1177/1470320312466125
   PubMed Web of Science ®Google Scholar
• Kolasa-Trela R, Fil K, Wypasek E, Undas A. Exercise stress testing enhances blood coagulation and impairs fibrinolysis in asymptomatic aortic valve stenosis. J Cardiol. 2015;65(6):501–507. doi:10.1016/j.jjcc.2014.07.019
   PubMed Web of Science ®Google Scholar
• Tomiyama H, Kimura Y, Mitsuhashi H, Kinouchi T, Yoshida H, Kushiro T, Doba N. Relationship between endothelial function and fibrinolysis in early hypertension. Hypertension. 1998;31(1 Pt 2):321–327.
   PubMed Web of Science ®Google Scholar
• Parissis JT, Venetsanou KF, Mentzikof DG, Kalantzi MV, Georgopoulou MV, Chrisopoulos N, Karas SM. Plasma levels of soluble cellular adhesion molecules in patients with arterial hypertension. Correlations with plasma endothelin-1. Eur J Intern Med. 2001;12(4):350–356.
   PubMedGoogle Scholar
• De Caterina R, Ghiadoni L, Taddei S, Virdis A, Almerigogna F, Basta G, Lazzerini G, Bernini W, Salvetti A. Soluble E-selectin in essential hypertension: a correlate of vascular structural changes. Am J Hypertens. 2001;14(3):259–266.
   PubMed Web of Science ®Google Scholar
• Felmeden DC, Spencer CG, Belgore FM, Blann AD, Beevers DG, Lip GY. Endothelial damage and angiogenesis in hypertensive patients: relationship to cardiovascular risk factors and risk factor management. Am J Hypertens. 2003;16(1):11–20.
   PubMed Web of Science ®Google Scholar
• Balta S, Mikhailidis DP, Demirkol S, Ozturk C, Kurtoglu E, Demir M, Celik T, Turker T, Iyisoy A. Endocan–a novel inflammatory indicator in newly diagnosed patients with hypertension: a pilot study. Angiology. 2014;65(9):773–777. doi:10.1177/0003319713513492
   PubMed Web of Science ®Google Scholar
• Perticone F, Sciacqua A, Maio R, Perticone M, Maas R, Boger RH, Tripepi G, Sesti G, Zoccali C. Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension. J Am Coll Cardiol. 2005;46(3):518–523. doi:10.1016/j.jacc.2005.04.040
   PubMed Web of Science ®Google Scholar
• DeSouza CA, Dengel DR, Macko RF, Cox K, Seals DR. Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. Am J Hypertens. 1997;10(12 Pt 1):1335–1341.
   PubMed Web of Science ®Google Scholar
• Nikolic SB, Adams MJ, Otahal P, Edwards LM, Sharman JE. Association of von Willebrand factor blood levels with exercise hypertension. Eur J Appl Physiol. 2015;115(5):1057–1065. doi:10.1007/s00421-014-3087-3
   PubMed Web of Science ®Google Scholar
• Pequignot JM, Peyrin L, Pérès G. Catecholamine-fuel interrelationships during exercise in fasting men. J Appl Physiol Respir Environ Exerc Physiol. 1980;48(1):109–113. doi:10.1152/jappl.1980.48.1.109
   PubMed Web of Science ®Google Scholar
• Péronnet F, Cléroux J, Perrault H, Cousineau D, de Champlain J, Nadeau R. Plasma norepinephrine response to exercise before and after training in humans. J Appl Physiol Respir Environ Exerc Physiol. 1981;51(4):812–815. doi:10.1152/jappl.1981.51.4.812
   PubMed Web of Science ®Google Scholar
• Marliss EB, Simantirakis E, Miles PD, Purdon C, Gougeon R, Field CJ, Halter JB, Vranic M. Glucoregulatory and hormonal responses to repeated bouts of intense exercise in normal male subjects. J Appl Physiol (1985). 1991;71(3):924–933. doi:10.1152/jappl.1991.71.3.924
   PubMed Web of Science ®Google Scholar
• Urhausen A, Weiler B, Coen B, Kindermann W. Plasma catecholamines during endurance exercise of different intensities as related to the individual anaerobic threshold. Eur J Appl Physiol Occup Physiol. 1994;69(1):16–20.
   PubMed Web of Science ®Google Scholar
• Kraemer WJ, Fleck SJ, Maresh CM, Ratamess NA, Gordon SE, Goetz KL, Harman EA, Frykman PN, Volek JS, Mazzetti SA, et al. Acute hormonal responses to a single bout of heavy resistance exercise in trained power lifters and untrained men. Can J Appl Physiol. 1999;24(6):524–537.
   PubMedGoogle Scholar
• O’Grady J, Oh V, Turner P. Effects of propranolol and oxprenolol on the vasoconstrictor response to noradrenaline in the superficial hand vein in man. Eur J Clin Pharmacol. 1978;14(2):83–85.
   PubMed Web of Science ®Google Scholar
• Laurent S, Juillerat L, London GM, Nussberger J, Brunner H, Safar ME. Increased response of brachial artery diameter to norepinephrine in hypertensive patients. Am J Physiol. 1988;255(1 Pt 2):H36–H43. doi:10.1152/ajpheart.1988.255.1.H36
   PubMedGoogle Scholar
• Newman KD, Williams LT, Bishopric NH, Lefkowitz RJ. Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding. J Clin Invest. 1978;61(2):395–402. doi:10.1172/JCI108950
   PubMed Web of Science ®Google Scholar
• Larsson PT, Wallén NH, Egberg N, Hjemdahl P. Alpha-adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation in vivo without affecting resting measurements. Clin Sci (Lond). 1992;82(4):369–376.
   PubMed Web of Science ®Google Scholar
• Stein CM, Brown N, Vaughan DE, Lang CC, Wood AJ. Regulation of local tissue-type plasminogen activator release by endothelium-dependent and endothelium-independent agonists in human vasculature. J Am Coll Cardiol. 1998;32(1):117–122.
   PubMed Web of Science ®Google Scholar
• Wall RT, Counts RB, Harker LA, Striker GE. Binding and release of factor VIII/von Willebrand’s factor by human endothelial cells. Br J Haematol. 1980;46(2):287–298.
   PubMed Web of Science ®Google Scholar
• Hjemdahl P, Chronos NA, Wilson DJ, Bouloux P, Goodall AH. Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Arterioscler Thromb. 1994;14(1):77–84.
   PubMedGoogle Scholar
• Lande K, Gjesdal K, Fønstelien E, Kjeldsen SE, Eide I. Effects of adrenaline infusion on platelet number, volume and release reaction. Thromb Haemost. 1985;54(2):450–453.
   PubMed Web of Science ®Google Scholar
• von Känel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol. 2000;65(6):357–369.
   PubMed Web of Science ®Google Scholar
• Huang EM, Detwiler TC. Characteristics of the synergistic actions of platelet agonists. Blood. 1981;57(4):685–691.
   PubMed Web of Science ®Google Scholar
• Lanza F, Beretz A, Stierlé A, Hanau D, Kubina M, Cazenave JP. Epinephrine potentiates human platelet activation but is not an aggregating agent. Am J Physiol. 1988;255(6 Pt 2):H1276–88. doi:10.1152/ajpheart.1988.255.6.H1276
   PubMedGoogle Scholar
• Lalau Keraly C, Kinlough-Rathbone RL, Packham MA, Suzuki H, Mustard JF. Conditions affecting the responses of human platelets to epinephrine. Thromb Haemost. 1988;60(2):209–216.
   PubMed Web of Science ®Google Scholar
• Goto S, Ikeda Y, Murata M, Handa M, Takahashi E, Yoshioka A, Fujimura Y, Fukuyama M, Handa S, Ogawa S. Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation. Circulation. 1992;86(6):1859–1863.
   PubMed Web of Science ®Google Scholar
• Larsson PT, Wallén NH, Hjemdahl P. Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation. 1994;89(5):1951–1957.
   PubMed Web of Science ®Google Scholar
• Chandler WL, Veith RC, Fellingham GW, Levy WC, Schwartz RS, Cerqueira MD, Kahn SE, Larson VG, Cain KC, Beard JC, et al. Fibrinolytic response during exercise and epinephrine infusion in the same subjects. J Am Coll Cardiol. 1992;19(7):1412–1420.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, Davies B. Effect of two formulations of a beta blocker on fibrinolytic response to maximum exercise. Med Sci Sports Exerc. 1989;21(4):369–373.
   PubMed Web of Science ®Google Scholar
• Yu Y, Xu Y, Zhang M, Wang Y, Zou W, Gu Y. Value of Assessing Autonomic Nervous Function by Heart Rate Variability and Heart Rate Turbulence in Hypertensive Patients. Int J Hypertens. 2018;2018:4067601. doi:10.1155/2018/4067601
   PubMed Web of Science ®Google Scholar
• Supiano MA, Hogikyan RV, Sidani MA, Galecki AT, Krueger JL. Sympathetic nervous system activity and alpha-adrenergic responsiveness in older hypertensive humans. Am J Physiol. 1999;276(3):E519–28. doi:10.1152/ajpendo.1999.276.3.E519
   PubMedGoogle Scholar
• Riondino S, Pignatelli P, Pulcinelli FM, Lenti L, Di Veroli C, Marigliano V, Gazzaniga PP. Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure. J Am Geriatr Soc. 1999;47(8):943–947.
   PubMed Web of Science ®Google Scholar
• Karabacak M, Dogan A, Turkdogan AK, Kapci M, Duman A, Akpinar O. Mean platelet volume is increased in patients with hypertensive crises. Platelets. 2014;25(6):423–426. doi:10.3109/09537104.2013.830181
   PubMed Web of Science ®Google Scholar
• Coban E, Adanir H, Bilgin D. The association of mean platelet volume levels with hypertensive retinopathy. Platelets. 2008;19(2):115–118. doi:10.1080/09537100701230451
   PubMed Web of Science ®Google Scholar
• Brodde OE, Daul A, O’Hara N, Bock KD. Increased density and responsiveness of alpha 2 and beta-adrenoceptors in circulating blood cells of essential hypertensive patients. J Hypertens Suppl. 1984;2(3):S111–4.
   PubMedGoogle Scholar
• Cottone S, Mulè G, Nardi E, Vadalà A, Guarneri M, Briolotta C, Arsena R, Palermo A, Riccobene R, Cerasola G. Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension. Am J Hypertens. 2006;19(3):313–318. doi:10.1016/j.amjhyper.2005.09.005
   PubMed Web of Science ®Google Scholar
• Rukhlenko OS, Dudchenko OA, Zlobina KE, Guria GT. Mathematical modeling of intravascular blood coagulation under wall shear stress. PLoS One. 2015;10(7):e0134028. doi:10.1371/journal.pone.0134028
   PubMed Web of Science ®Google Scholar
• Gonzales JU, Thistlethwaite JR, Thompson BC, Scheuermann BW. Exercise-induced shear stress is associated with changes in plasma von Willebrand factor in older humans. Eur J Appl Physiol. 2009;106(5):779–784. doi:10.1007/s00421-009-1074-x
   PubMed Web of Science ®Google Scholar
• Lin X, el-Sayed MS, Waterhouse J, Reilly T. Activation and disturbance of blood haemostasis following strenuous physical exercise. Int J Sports Med. 1999;20(3):149–153. doi:10.1055/s-2007-971109
   PubMed Web of Science ®Google Scholar
• von Känel R, Hong S, Pung MA, Mills PJ. Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Am J Hypertens. 2007;20(6):670–675. doi:10.1016/j.amjhyper.2007.01.005
   PubMed Web of Science ®Google Scholar
• Shaper AG, Wannamethee G, Walker M. Physical activity, hypertension and risk of heart attack in men without evidence of ischaemic heart disease. J Hum Hypertens. 1994;8(1):3–10.
   PubMed Web of Science ®Google Scholar
• el-Sayed MS, el-Sayed Ali Z, Ahmadizad S. Exercise and training effects on blood haemostasis in health and disease: an update. Sports Med. 2004;34(3):181–200. doi:10.2165/00007256-200434030-00004
   PubMed Web of Science ®Google Scholar
• Sullivan PA, Grosch C, Lawless D, O’Connor DT. Short-term strenuous exercise training: effects on blood pressure and hormonal levels in mild hypertension. Ir J Med Sci. 1992;161(12):666–669.
   PubMed Web of Science ®Google Scholar
• Costa O, Freitas J, Puig J, Carvalho MJ, Freitas A, Ramos J, Puga N, Lomba I, Fernandes P, de Freitas F. Spectrum analysis of the variability of heart rate in athletes. Rev Port Cardiol. 1991;10(1):23–28.
   PubMedGoogle Scholar
• Lundberg Slingsby MH, Nyberg M, Egelund J, Mandrup CM, Frikke-Schmidt R, Kirkby NS, Hellsten Y. Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women. J Thromb Haemost. 2017;15(12):2419–2431. doi:10.1111/jth.13866
   PubMed Web of Science ®Google Scholar
• Fernhall B, Szymanski LM, Gorman PA, Milani J, Paup DC, Kessler CM. Fibrinolytic activity is not dependent upon exercise mode in post-myocardial infarction patients. Eur J Appl Physiol Occup Physiol. 1998;78(3):247–252. doi:10.1007/s004210050415
   PubMed Web of Science ®Google Scholar
• Szymanski LM, Pate RR. Fibrinolytic responses to moderate intensity exercise. Comparison of physically active and inactive men. Arterioscler Thromb. 1994;14(11):1746–1750.
   PubMedGoogle Scholar
• Watts EJ. Haemostatic changes in long-distance runners and their relevance to the prevention of ischaemic heart disease. Blood Coagul Fibrinolysis. 1991;2(2):221–225.
   PubMed Web of Science ®Google Scholar
• Yazici M, Kaya A, Kaya Y, Albayrak S, Cinemre H, Ozhan H. Lifestyle modification decreases the mean platelet volume in prehypertensive patients. Platelets. 2009;20(1):58–63. doi:10.1080/09537100802613449
   PubMed Web of Science ®Google Scholar
• Gris JC, Schved JF, Feugeas O, Aguilar-Martinez P, Arnaud A, Sanchez N, Sarlat C. Impact of smoking, physical training and weight reduction on FVII, PAI-1 and hemostatic markers in sedentary men. Thromb Haemost. 1990;64(4):516–520.
   PubMed Web of Science ®Google Scholar
• Schuit AJ, Schouten EG, Kluft C, de Maat M, Menheere PP, Kok FJ. Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. Thromb Haemost. 1997;78(2):845–851.
   PubMed Web of Science ®Google Scholar
• Stratton JR, Chandler WL, Schwartz RS, Cerqueira MD, Levy WC, Kahn SE, Larson VG, Cain KC, Beard JC, Abrass IB. Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults. Circulation. 1991;83(5):1692–1697.
   PubMed Web of Science ®Google Scholar
• van Den Burg PJ, Hospers JE, van Vliet M, Mosterd WL, Bouma BN, Huisveld IA. Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in young sedentary men. J Appl Physiol (1985). 1997;82(2):613–620. doi:10.1152/jappl.1997.82.2.613
   PubMed Web of Science ®Google Scholar
• van Den Burg PJ, Hospers JE, Mosterd WL, Bouma BN, Huisveld IA. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J Appl Physiol (1985). 2000;88(5):1558–1564. doi:10.1152/jappl.2000.88.5.1558
   PubMed Web of Science ®Google Scholar
• Bodary PF, Yasuda N, Watson DD, Brown AS, Davis JM, Pate RR. Effects of short-term exercise training on plasminogen activator inhibitor (PAI-1). Med Sci Sports Exerc. 2003;35(11):1853–1858. doi:10.1249/01.MSS.0000093751.82616.F0
   PubMed Web of Science ®Google Scholar
• Hilberg T, Nowacki PE, Müller-Berghaus G, Gabriel HH. Changes in blood coagulation and fibrinolysis associated with maximal exercise and physical conditioning in women taking low dose oral contraceptives. J Sci Med Sport. 2000;3(4):383–390.
   PubMedGoogle Scholar
• Kupchak BR, Creighton BC, Aristizabal JC, Dunn-Lewis C, Volk BM, Ballard KD, Comstock BA, Maresh CM, Kraemer WJ, Volek JS. Beneficial effects of habitual resistance exercise training on coagulation and fibrinolytic responses. Thromb Res. 2013;131(6):e227–34. doi:10.1016/j.thromres.2013.02.014
   PubMed Web of Science ®Google Scholar
• Hanke AA, Staib A, Görlinger K, Perrey M, Dirkmann D, Kienbaum P. Whole blood coagulation and platelet activation in the athlete: a comparison of marathon, triathlon and long distance cycling. Eur J Med Res. 2010;15(2):59–65.
   PubMed Web of Science ®Google Scholar
• Cornelissen VA, Fagard RH. Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors. Hypertension. 2005;46(4):667–675. doi:10.1161/01.HYP.0000184225.05629.51
   PubMed Web of Science ®Google Scholar
• Dubbert PM, Martin JE, Cushman WC, Meydrech EF, Carroll RG. Endurance exercise in mild hypertension: effects on blood pressure and associated metabolic and quality of life variables. J Hum Hypertens. 1994;8(4):265–272.
   PubMed Web of Science ®Google Scholar
• Masroor S, Bhati P, Verma S, Khan M, Hussain ME. Heart rate variability following combined aerobic and resistance training in sedentary hypertensive women: a randomised control trial. Indian Heart J. 2018;70(Suppl 3):S28–S35. doi:10.1016/j.ihj.2018.03.005
   PubMedGoogle Scholar
• Hinderliter A, Sherwood A, Gullette EC, Babyak M, Waugh R, Georgiades A, Blumenthal JA. Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension. Arch Intern Med. 2002;162(12):1333–1339.
   PubMedGoogle Scholar
• Zanettini R, Bettega D, Agostoni O, Ballestra B, Del Rosso G, Di Michele R, Mannucci PM. Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. Cardiology. 1997;88(5):468–473. doi:10.1159/000177378
   PubMed Web of Science ®Google Scholar
• Son WM, Sung KD, Cho JM, Park SY. Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension. Menopause. 2017;24(3):262–268. doi:10.1097/GME.0000000000000765
   PubMed Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G, Oshima T. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999;100(11):1194–1202.
   PubMed Web of Science ®Google Scholar
• Jarrete AP, Novais IP, Nunes HA, Puga GM, Delbin MA, Zanesco A. Influence of aerobic exercise training on cardiovascular and endocrine-inflammatory biomarkers in hypertensive postmenopausal women. J Clin Transl Endocrinol. 2014;1(3):108–114. doi:10.1016/j.jcte.2014.07.004
   PubMedGoogle Scholar
• Nagashima J, Musha H, Takada H, Matsumoto N, Fujimaki R, Ishige N, Aono J, Murayama M. Influence of physical fitness and smoking on the coagulation system in hypertensive patients: effect on prothrombin fragment F1+2. Intern Med. 2007;46(13):933–936.
   PubMed Web of Science ®Google Scholar
• Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V. Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. Circulation. 1986;74(5):939–944.
   PubMed Web of Science ®Google Scholar
• de Meirelles LR, Mendes-Ribeiro AC, Mendes MA, Da Silva MN, Ellory JC, Mann GE, Brunini TM. Chronic exercise reduces platelet activation in hypertension: upregulation of the L-arginine-nitric oxide pathway. Scand J Med Sci Sports. 2009;19(1):67–74. doi:10.1111/j.1600-0838.2007.00755.x
   PubMed Web of Science ®Google Scholar
• Barbaro NR, de Araújo TM, Tanus-Santos JE, Anhê GF, Fontana V, Moreno H. Vascular damage in resistant hypertension: TNF-alpha inhibition effects on endothelial cells. Biomed Res Int. 2015;2015:631594. doi:10.1155/2015/631594
   PubMed Web of Science ®Google Scholar
• Miyata S, Noda A, Hara Y, Ueyama J, Kitaichi K, Kondo T, Koike Y. Nitric oxide plasma level as a barometer of endothelial dysfunction in factory workers. Exp Clin Endocrinol Diabetes. 2017;125(10):684–689. doi:10.1055/s-0043-110054
   PubMed Web of Science ®Google Scholar
• Gano LB, Donato AJ, Pierce GL, Pasha HM, Magerko KA, Roeca C, Seals DR. Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics. 2011 Jul 27;43(14):895–902. doi:10.1152/physiolgenomics.00204.2010
   PubMed Web of Science ®Google Scholar
• Franzoni F, Ghiadoni L, Galetta F, Plantinga Y, Lubrano V, Huang Y, Salvetti G, Regoli F, Taddei S, Santoro G, et al. Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men. Am J Hypertens. 2005 Apr;18(4 Pt 1):510–516. doi:10.1016/j.amjhyper.2004.11.006
   PubMed Web of Science ®Google Scholar
• Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, Guralnik JM, Ferrucci L. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004;59(3):242–248.
   PubMed Web of Science ®Google Scholar
• Lima LG, Bonardi JM, Campos GO, Bertani RF, Scher LM, Louzada-Junior P, Moriguti JC, Ferriolli E, Lima NK. Effect of aerobic training and aerobic and resistance training on the inflammatory status of hypertensive older adults. Aging Clin Exp Res. 2015;27(4):483–489. doi:10.1007/s40520-014-0307-y
   PubMed Web of Science ®Google Scholar
• Fischer CP, Plomgaard P, Hansen AK, Pilegaard H, Saltin B, Pedersen BK. Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004;287(6):E1189–94. doi:10.1152/ajpendo.00206.2004
   PubMed Web of Science ®Google Scholar
• Mammi C, la Sala A, Volterrani M, Gatta L, Antelmi A, Feraco A, Caminiti G, Marazzi G, Vitale C, Caprio M, et al. Exercise training reduces serum capacity to induce endothelial cell death in patients with chronic heart failure. Eur J Heart Fail. 2011;13(6):642–650. doi:10.1093/eurjhf/hfr026
   PubMed Web of Science ®Google Scholar
• Tanahashi K, Akazawa N, Miyaki A, Choi Y, Ra SG, Matsubara T, Kumagai H, Oikawa S, Maeda S. Aerobic exercise training decreases plasma asymmetric dimethylarginine concentrations with increase in arterial compliance in postmenopausal women. Am J Hypertens. 2014;27(3):415–421. doi:10.1093/ajh/hpt217
   PubMed Web of Science ®Google Scholar
• Gliemann L, Rytter N, Piil P, Nilton J, Lind T, Nyberg M, Cocks M, Hellsten Y. The endothelial mechanotransduction protein platelet endothelial cell adhesion molecule-1 is influenced by aging and exercise training in human skeletal muscle. Front Physiol. 2018;9:1807. doi:10.3389/fphys.2018.01807
   PubMed Web of Science ®Google Scholar
• Sponton CH, Rezende TM, Mallagrino PA, Franco-Penteado CF, Bezerra MA, Zanesco A. Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise. Eur J Cardiovasc Prev Rehabil. 2010;17(6):676–681. doi:10.1097/HJR.0b013e32833a1301
   PubMedGoogle Scholar
• Izadi MR, Ghardashi Afousi A, Asvadi Fard M, Babaee Bigi MA. High-intensity interval training lowers blood pressure and improves apelin and NOx plasma levels in older treated hypertensive individuals. J Physiol Biochem. 2018;74(1):47–55. doi:10.1007/s13105-017-0602-0
   PubMed Web of Science ®Google Scholar
• Swift DL, Earnest CP, Blair SN, Church TS. The effect of different doses of aerobic exercise training on endothelial function in postmenopausal women with elevated blood pressure: results from the DREW study. Br J Sports Med. 2012;46(10):753–758. doi:10.1136/bjsports-2011-090025
   PubMed Web of Science ®Google Scholar
• Skrha J, Hodinár A, Kvasnicka J, Hilgertová J. Relationship of oxidative stress and fibrinolysis in diabetes mellitus. Diabet Med. 1996;13(9):800–805. doi:10.1002/(SICI)1096-9136(199609)13:9<800::AID-DIA178>3.0.CO;2-Q
   PubMed Web of Science ®Google Scholar
• Killewich LA, Macko RF, Montgomery PS, Wiley LA, Gardner AW. Exercise training enhances endogenous fibrinolysis in peripheral arterial disease. J Vasc Surg 2004;40(4):741–745. doi:10.1016/j.jvs.2004.07.030
   PubMed Web of Science ®Google Scholar
• Pescatello LS, Arena R, Riebe D, Thompson PD. 2014. American College of Sports Medicine. Guidelines for exercise testing and prescription. 9th ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins Health. p. 456p.
   Google Scholar