TEG®6s system measures the contributions of both platelet count and platelet function to clot formation at the site-of-care

References

• Hoffman M, Monroe DM 3rd. A cell-based model of hemostasis. Thromb Haemost 2001;85:958–965. doi:10.1055/s-0037-1615947.
   PubMed Web of Science ®Google Scholar
• Brown LM, Call MS, Knudson MM, Cohen MJ, Group TO. A normal platelet count may not be enough: the impact of admission platelet count on mortality and transfusion in severely injured trauma patients. J Trauma 2011;71:S337. doi:10.1097/TA.0b013e318227f67c.
   PubMedGoogle Scholar
• Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg 2012;73:13. doi:10.1097/TA.0b013e318256deab.
   PubMed Web of Science ®Google Scholar
• Chang R, Cardenas JC, Wade CE, Holcomb JB. Advances in the understanding of trauma-induced coagulopathy. Blood 2016;128:1043–1049. doi:10.1182/blood-2016-01-636423.
   PubMed Web of Science ®Google Scholar
• Varghese S, Unni M, Mukundan N, Ramji RL. Platelet functions in cardiopulmonary bypass surgery. Med J Armed Forces India 2005;61:316–321. doi:10.1016/S0377-1237(05)80053-X.
   PubMedGoogle Scholar
• Rinder CS, Mathew JP, Rinder HM, Bonan J, Ault KA, Smith BR. Modulation of platelet surface adhesion receptors during cardiopulmonary bypass. Anesthesiology 1991;75:563–570. doi:10.1097/00000542-199110000-00004.
   PubMed Web of Science ®Google Scholar
• Hartmann J, Mason D, Achneck H. Thromboelastography (TEG) point-of-care diagnostic for hemostasis management. Point Care 2018;17:15–22.
   Web of Science ®Google Scholar
• Ramiz S, Hartmann J. Clinical utility of viscoelastic testing (TEG and ROTEM analyzers) in the management of old and new therapies for hemophilia. Am J Hematol 2019;94:249–256. doi:10.1002/ajh.25319.
   PubMed Web of Science ®Google Scholar
• Gurbel PA, Bliden KP, Tantry US, Monroe AL, Muresan AA, Brunner NE, Lopez-Espina CG, Delmenico PR, Cohen E, Raviv G. First report of the point-of-care TEG: a technical validation study of the TEG-6S system. Platelets 2016;27:642–649. doi:10.3109/09537104.2016.1153617.
   PubMed Web of Science ®Google Scholar
• Gurbel PA, Bliden KP, Navickas IA, Mahla E, Dichiara J, Suarez TA, Antonino MJ, Tantry US, Cohen E. Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events. Am Heart J 2010;160:346–354. doi:10.1016/j.ahj.2010.05.034.
   PubMed Web of Science ®Google Scholar
• Mousa SA, Khurana S, Forsythe MS. Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists. Arterioscler Thromb Vasc Biol 2000;20:1162–1167. doi:10.1161/01.ATV.20.4.1162.
   PubMed Web of Science ®Google Scholar
• Plotkin AJ, Wade CE, Jenkins DH, Smith KA, Noe JC, Park MS, Perkins JG, Holcomb JB. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma Acute Care Surg 2008;64:S64–S68. doi:10.1097/TA.0b013e318160772d.
   Google Scholar
• Paniccia R, Priora R, Liotta AA, Abbate R. Platelet function tests: a comparative review. Vasc Health Risk Manag 2015;11:133. doi:10.2147/VHRM.
   PubMed Web of Science ®Google Scholar
• Dias JD, Haney EI, Mathew BA, Lopez-Espina CG, Orr AW, Popovsky MA. New-generation thromboelastography: comprehensive evaluation of citrated and heparinized blood sample storage effect on clot-forming variables. Arch Pathol Lab Med 2017;141:569–577. doi:10.5858/arpa.2016-0088-OA.
   PubMed Web of Science ®Google Scholar
• Association WM. World medical association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 2013;310:2191. doi:10.1001/jama.2013.281053.
   PubMed Web of Science ®Google Scholar
• Platton S, McCormick A, Bukht M, Gurney D, Holding I, Moore GW. A multicenter study to evaluate automated platelet aggregometry on Sysmex CS-series coagulation analyzers-preliminary findings. Res Pract Thromb Haemost 2018;2:778–789. Epub 2018/ 10/24. doi:10.1002/rth2.12140.
   PubMed Web of Science ®Google Scholar
• Reece MJ, Klein AA, Salviz EA, Hastings A, Ashworth A, Freeman C, Luddington RJ, Nair S, Besser MW. Near-patient platelet function testing in patients undergoing coronary artery surgery: a pilot study. Anaesthesia 2011;66:97–103. Epub 2011/ 01/25. doi:10.1111/anae.2011.66.issue-2.
   PubMed Web of Science ®Google Scholar
• Cattaneo M, Cerletti C, Harrison P, Hayward CP, Kenny D, Nugent D, Nurden P, Rao AK, Schmaier AH, Watson SP, et al. Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH. J Thromb Haemost 2013;11:1183–1189. doi:10.1111/jth.2013.11.issue-6.
   Web of Science ®Google Scholar
• Dias JD, Sauaia A, Achneck HE, Hartmann J, Moore EE. Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: a systematic review and analysis. J Thromb Haemost 2019;17:984–994. Epub 2019/ 04/05. doi:10.1111/jth.2019.17.issue-6.
   PubMed Web of Science ®Google Scholar
• Dias JD, Pottgiesser T, Hartmann J, Duerschmied D, Bode C, Achneck HE. Comparison of three common whole blood platelet function tests for in vitro P2Y12 induced platelet inhibition. J Thromb Thrombolysis 2019. doi:10.1007/s11239-019-01971-1.
   PubMed Web of Science ®Google Scholar
• Neal MD, Moore EE, Walsh M, Thomas S, Callcut RA, Kornblith LZ, Schreiber M, Ekeh AP, Singer AJ, Lottenberg L, et al. A comparison between the TEG® 6s and TEG® 5000 analyzers to assess coagulation in trauma patients. J Trauma Acute Care Surg 9000. Published Online Ahead of Print. doi:10.1097/TA.0000000000002545.
   Google Scholar
• Oshita K, Az-ma T, Osawa Y, Yuge O. Quantitative measurement of thromboelastography as a function of platelet count. Anesth Analg 1999;89:296–299. doi:10.1097/00000539-199908000-00006.
   PubMed Web of Science ®Google Scholar
• Bowbrick VA, Mikhailidis DP, Stansby G. Influence of platelet count and activity on thromboelastography parameters. Platelets 2003;14:219–224. doi:10.1080/0953710031000118849.
   PubMed Web of Science ®Google Scholar
• Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, et al. Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: A pragmatic randomized clinical trial comparing a viscoelastic assay to conventional coagulation assays. Ann Surg 2016;263:1051–1059. doi:10.1097/SLA.0000000000001608.
   PubMed Web of Science ®Google Scholar
• Johansson PI, Sorensen AM, Larsen CF, Windelov NA, Stensballe J, Perner A, Rasmussen LS, Ostrowski SR. Low hemorrhage-related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography-directed hemostatic resuscitation with plasma and platelets. Transfusion 2013;53:3088–3099. doi:10.1111/trf.2013.53.issue-12.
   PubMed Web of Science ®Google Scholar
• Stensballe J, Ostrowski SR, Johansson PI. Viscoelastic guidance of resuscitation. Curr Opin Anaesthesiol 2014;27:212–218. doi:10.1097/ACO.0000000000000051.
   PubMed Web of Science ®Google Scholar
• Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, Civelek A, Arsan S. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. J Card Surg 2009;24:404–410. doi:10.1111/jcs.2009.24.issue-4.
   PubMed Web of Science ®Google Scholar
• Royston D, von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. Br J Anaesth 2001;86:575–578. doi:10.1093/bja/86.4.575.
   PubMed Web of Science ®Google Scholar
• Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999;88:312–319. doi:10.1097/00000539-199902000-00016.
   PubMed Web of Science ®Google Scholar
• Gurbel PA, Bliden KP, Guyer K, Cho PW, Zaman KA, Kreutz RP, Bassi AK, Tantry US. Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. J Am Coll Cardiol 2005;46:1820–1826. doi:10.1016/j.jacc.2005.07.041.
   PubMed Web of Science ®Google Scholar
• Elliott A, Wetzel J, Roper T, Pivalizza E, McCarthy J, Wallace C, Hess MJ, Peng H, Rahbar MH, Sangha N, et al. Thromboelastography in patients with acute ischemic stroke. Int J Stroke 2015;10:194–201. doi:10.1111/j.1747-4949.2012.00919.x.
   PubMedGoogle Scholar
• Castellino FJ, Chapman MP, Donahue DL, Thomas S, Moore EE, Wohlauer MV, Fritz B, Yount R, Ploplis V, Davis P, et al. Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats. J Trauma Acute Care Surg 2014;76:1169–1176.
   PubMed Web of Science ®Google Scholar
• Gurbel PA, Bliden KP, Navickas IA, Mahla E, Dichiara J, Suarez TA, Antonino MJ, Tantry US, Cohen E. Adenosine diphosphate–induced platelet-fibrin clot strength: A new thrombelastographic indicator of long-term poststenting ischemic events. Am Heart J 2010;160:346–354. doi:10.1016/j.ahj.2010.05.034.
   PubMed Web of Science ®Google Scholar
• Mahla E, Suarez TA, Bliden KP, Rehak P, Metzler H, Sequeira AJ, Cho P, Sell J, Fan J, Antonino MJ, et al. Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG (TARGET-CABG) study. Circ Cardiovasc Interventions 2012;5:261–269. doi:10.1161/CIRCINTERVENTIONS.111.967208.
   PubMed Web of Science ®Google Scholar
• Sivapalan P, Back AC, Ostrowski SR, Ravn HB, Johansson PI. Transfusion requirements in elective cardiopulmonary bypass surgery patients: predictive value of Multiplate and Thromboelastography (TEG) platelet mapping assay. Scand J Clin Lab Invest 2017;77:345–351. doi:10.1080/00365513.2017.1325000.
   PubMed Web of Science ®Google Scholar
• Kasivisvanathan R, Abbassi-Ghadi N, Kumar S, Mackenzie H, Thompson K, James K, Mallett SV. Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non-cardiac surgery. Br J Surg 2014;101:1383–1390. doi:10.1002/bjs.2014.101.issue-11.
   PubMed Web of Science ®Google Scholar
• Agarwal S, Johnson RI, Shaw M. Preoperative point-of-care platelet function testing in cardiac surgery. J Cardiothorac Vasc Anesth 2015;29:333–341. doi:10.1053/j.jvca.2014.06.025.
   PubMed Web of Science ®Google Scholar
• Tapia NM, Chang A, Norman M, Welsh F, Scott B, Wall MJ Jr., Mattox KL, Suliburk J. TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. J Trauma Acute Care Surg 2013;74:378–385. discussion Epub 2013/ 01/29. doi:10.1097/TA.0b013e31827e20e0.
   PubMed Web of Science ®Google Scholar