The use of genetic epidemiology to guide classification in child and adult psychopathology

References

• Alarcon M, Cantor RM, Liu J, Gilliam TC, Geschwind DH. Autism Genetic Research Exchange Consortium. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. American Journal of Human Genetics 2002; 70(1)60–71
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders (text revision). Author, Washington, DC 2000
   Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Washington 1994
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (3rd ed). Washington 1980
   Google Scholar
• Amundadottir LT, et al. A common variant associated with prostate cancer in European and African populations. Nature Genetics 2006; 38: 652–658
   PubMed Web of Science ®Google Scholar
• Angst J, Gamma A, Benazzi F, Ajdacic V, Eich D, Rossler W. Toward a re-definition of subthreshold bipolarity: Epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. Journal of Affective Disorders 2003; 73: 133–146
   PubMed Web of Science ®Google Scholar
• Angst J. The bipolar spectrum. British Journal of Psychiatry 2007; 190: 189–191
   PubMed Web of Science ®Google Scholar
• Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine 1995; 25: 63–77
   PubMed Web of Science ®Google Scholar
• Benazzi F. Bipolar disorder–focus on bipolar II disorder and mixed depression. Lancet 2007; 17: 935–945
   Google Scholar
• Bennett TA, Szatmari P, Bryson SE, Volden J, Zwaigenbaum L, Vaccarella L, et al. Differentiating autism and Asperger Syndrome on the basis of language delay or impairment. Journal of Autism and Developmental Disorders 2007, Epub, August 2007
   PubMedGoogle Scholar
• Billstedt E, Gillberg C, Gillberg C. Autism after adolescence: Population-based 13- to 22-year follow-up study of 120 individuals with autism diagnosed in childhood. Journal of Autism and Developmental Disorders 2005; 35: 351–360
   PubMed Web of Science ®Google Scholar
• Bradford Y, Haines J, Hutcheson H, Gardiner M, Braun T, Sheffield V, et al. Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics 2001; 8: 539–547
   Google Scholar
• Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder. Schizophrenia Bulletin 2007; 33: 21–32
   PubMed Web of Science ®Google Scholar
• Buxbaum JD, Silverman JM, Smith CJ, Kilifarski M, Reichert J, Hollander E, et al. Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. American Journal of Human Genetics 2001; 68: 1514–1520
   PubMed Web of Science ®Google Scholar
• Carcani-Rathwell I, Rabe-Hasketh S, Santosh PJ. Repetitive and stereotyped behaviours in pervasive developmental disorders. Journal of Child Psychology and Psychiatry 2006; 47: 573–581
   PubMed Web of Science ®Google Scholar
• Cederlund M, Hagberg B, Billstedt E, Gillberg IC, Gillberg C. Asperger Syndrome and Autism: A Comparative Longitudinal Follow-Up Study More than 5 Years after Original Diagnosis. Journal of Autism and Developmental Disorders 2007; Epub, March 2007
   Google Scholar
• Chen GK, Kono N, Geschwind DH, Cantor RM. Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder. Molecular Psychiatry 2006; 11: 214–220
   PubMed Web of Science ®Google Scholar
• CLSA. Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics 2001; 105: 539–547
   Web of Science ®Google Scholar
• Cuccaro ML, Shao Y, Grubber J, Slifer M, Wolpert CM, Donnelly SL. Factor analysis of restricted and repetitive behaviors in autism using the Autism Diagnostic Interview-R. Child Psychiatry and Human Development 2003; 34: 3–17
   PubMed Web of Science ®Google Scholar
• Dierker LC, Merikangas KR, Szatmari P. The influence of parental diagnostic concordance on risk for psychopathology in offspring. Journal of American Academy of Child and Adolescent Psychiatry 1999; 38: 280–288
   PubMed Web of Science ®Google Scholar
• Dolan RJ. Emotion, cognition, and behavior. Science 2006; 298: 1191–1194
   Google Scholar
• Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461–1463
   PubMed Web of Science ®Google Scholar
• Eapen V, Pauls DL, Robertson MM. The role of clinical phenotypes in understanding the genetics of obsessive-compulsive disorder. Journal of Psychosomatic Research 2006; 61: 359–364
   PubMed Web of Science ®Google Scholar
• Field SF, Howson JM, Smyth DJ, Walker NM, Dunger DB, et al. Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects. Diabetologia 2007; 50: 212–213
   PubMed Web of Science ®Google Scholar
• Flint J, Munafo MR. The endophenotype concept in psychiatric genetics. Psychological Medicine 2007; 37: 163–180
   PubMed Web of Science ®Google Scholar
• Folstein S, Rutter M. Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, and Allied Disciplines 1977; 18: 297–321
   PubMed Web of Science ®Google Scholar
• Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: An update. Journal of Autism and Developmental Disorders 2003; 33: 365–382
   PubMed Web of Science ®Google Scholar
• Freedman ML, Haiman CA, Patterson N, McDonald GJ, Tandon A, Waliszewska A, et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proceedings of Natural Academy Science 2006; 103: 14068–14073
   PubMed Web of Science ®Google Scholar
• Frid PJ. Commentary on ‘DSM-IV criteria were reliable and accurate in differentiating pervasive developmental disorder (PDD) from non-PDD and autism from Asperger's disorder’. Evidence Based Mental Health 1998; 1: 121
   Google Scholar
• Frith U. Emmanuel Miller lecture: Confusions and controversies about Asperger syndrome. Journal of Child Psychology and Psychiatry 2004; 45: 672–686
   PubMed Web of Science ®Google Scholar
• Fyer AJ, Mannuzza S, Chapman TF, Martin LY, Klein DF. Specificity of familial aggregation of phobic disorders. Archives of General Psychiatry 2005; 52: 564–573
   Google Scholar
• Georgiades S, Szatmari P, Zwaigenbaum L, Duku E, Bryson SE, Roberts W, et al. The Structure of the Autism Symptom Phenotype: A Proposed Multidimensional Model. Journal of American Academy of Child and Adolescent Psychiatry 2007; 46: 188–196
   PubMed Web of Science ®Google Scholar
• Goin-Kochel RP, Abbacchi A, Constantino JN. Autism Genetic Resource Exchange Consortium. Lack of evidence for increased genetic loading for autism among families of affected females: A replication from family history data in two large samples. Autism 2007; 11: 279–86
   PubMedGoogle Scholar
• Gottesman II, Gould TD. The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry 2003; 160: 636–645
   PubMed Web of Science ®Google Scholar
• Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nature Genetics 2006; 38: 320–323
   PubMed Web of Science ®Google Scholar
• Grillon C, Dierker L, Merikangas KR. Startle modulation in children at risk for anxiety disorders and/or alcoholism. Journal of American Academy of Child and Adolescent Psychiatry 1997; 36: 925–932
   PubMed Web of Science ®Google Scholar
• Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, et al. Association analysis of 6,736 U. K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006; 55: 2640–2644
   PubMed Web of Science ®Google Scholar
• Hill SY, Neiswanger K. The value of narrow psychiatric phenotypes and ‘super’ normal controls. CRC Press, New York 1997
   Google Scholar
• Howlin P, Goode S, Hutton J, Rutter M. Adult outcome for children with autism. Journal of Child Psychology and Psychiatry 2004; 45: 212–229
   PubMed Web of Science ®Google Scholar
• Howlin P. Outcome in high-functioning adults with autism with and without early language delays: Implications for the differentiation between autism and Asperger syndrome. Journal of Autism and Developmental Disorders 2003; 33: 3–13
   PubMed Web of Science ®Google Scholar
• Hurley RS, Losh M, Parlier M, Reznick JS, Piven J. The Broad Autism Phenotype Questionnaire. Journal of Autism and Developmental Disorders 2006, E Pub 2006 Dec
   PubMed Web of Science ®Google Scholar
• The International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437: 1299–1320
   PubMed Web of Science ®Google Scholar
• Jones A, Cork C, Chowdhury U. Autistic spectrum disorders. 1: Presentation and assessment. Community Practice 2006; 79: 97–98
   PubMedGoogle Scholar
• Kendell RE. Clinical validity. Psychological Medicine 1989; 19: 45–55
   PubMed Web of Science ®Google Scholar
• Kendler KS. The super-normal control group in psychiatric genetics: Post artifactual evidence for aggregation. Psychiatric Genetics 1990; 1: 45–53
   Google Scholar
• Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. Major depression and phobias: The genetic and environmental sources of comorbidity. Psychological Medicine 1993; 23: 361–371
   PubMed Web of Science ®Google Scholar
• Kendler KS, Eaves LJ, Walters EE, Neale MC, Health AC, Kessler RC. The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Archives of General Psychiatry 1996; 53: 391–399
   PubMed Web of Science ®Google Scholar
• Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. A population-based twin study of major depression in women: The impact of varying definitions of illness. Archives of General Psychiatry 1992; 49: 257–266
   PubMed Web of Science ®Google Scholar
• Kendler K, Walters E, Neale M, Kessler R, Heath A, Eaves L. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Archives of General Psychiatry 1995; 52: 374–383
   PubMed Web of Science ®Google Scholar
• Kessler RC, Üstün TB. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). International Journal Methods Psychiatric Research 2004; 13: 93–121
   PubMed Web of Science ®Google Scholar
• Klein DF. The utility of the super-normal control group in psychiatric genetics. Psychiatric Genetics 1993; 3: 17–19
   Web of Science ®Google Scholar
• Klin A, Pauls D, Schultz R, Volkmar F. Three diagnostic approaches to Asperger syndrome: Implications for research. Journal of Autism and Developmental Disorders 2005; 35: 221–34
   PubMed Web of Science ®Google Scholar
• Kolevzon A, Smith CJ, Schmeidler J, Buxbaum JD, Silverman JM. Familial symptom domains in monozygotic siblings with autism. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 2004; 129B: 76–81
   PubMed Web of Science ®Google Scholar
• Krug DA, Arik J, Almond P. Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry 1980; 21: 221–229
   PubMed Web of Science ®Google Scholar
• Le Couteur A, Bailey A, Goode S, Pickles A, Robertson S, Gottesman I, Rutter M. A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, and Allied Disciplines 1996; 37: 785–801
   PubMed Web of Science ®Google Scholar
• Le Couteur A, Rutter M, Lord C. Autism Diagnostic Interview: A standardized investigator-based instrument. Journal of Autism & Developmental Disorders 1989; 19: 363–387
   PubMed Web of Science ®Google Scholar
• Lenox RH, Gould TD, Manji HK. Endophenotypes in bipolar disorder. American Journal of Medical Genetics 2002; 114: 391–406
   PubMed Web of Science ®Google Scholar
• Lesage S, Zouali H, Cezard JP, Colombel JF, Belaiche J, Almer S, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. American Journal of Human Genetics 2002; 70: 845–857
   PubMed Web of Science ®Google Scholar
• Lord C, Rutter M, LeCouteur A. Autism diagnostic interview–revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders 1994; 24: 659–685
   PubMed Web of Science ®Google Scholar
• Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, et al. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. American Journal of Human Genetics 2005; 77: 377–388
   PubMed Web of Science ®Google Scholar
• Ma DQ, Jaworski J, Menold MM, Donnelly S, Abramson RK, Wright HH, et al. Ordered-subset analysis of savant skills in autism for 15q11-q13. American Journal of Medical Genetics B Neuropsychiatric Genetics 2005; 135: 38–41
   Google Scholar
• MacLean JE, Szatmari P, Jones MB, Bryson SE, Mahoney WJ, Bartolucci G, et al. Familial factors influence level of functioning in pervasive developmental disorder. Journal of the American Academy of Child and Adolescent Psychiatry 1999; 38: 746–753
   PubMed Web of Science ®Google Scholar
• Mahoney WJ, Szatmari P, MacLean JE, MacLean JE, Bryson SE, Bartolucci G, et al. Reliability and accuracy of differentiating Pervasive Developmental Disorder Subtypes. Journal of American Academy of Child and Adolescent Psychiatry 1998; 37: 278–285
   PubMed Web of Science ®Google Scholar
• Maier W, Lichtermann D, Franke P, Heun R, Falkai P, Rietschel M. The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophrenia Research 2002; 57(2–3)259–266
   PubMed Web of Science ®Google Scholar
• Maier W, Lichtermann D, Minges J. The relationship of alcoholism and unipolar depression: A controlled family study. Journal of Psychiatric Research 1994; 28: 303–317
   PubMed Web of Science ®Google Scholar
• Maier W, Merikangas KR. Co-occurrence and co-transmission of affective disorders and alcoholism in families. British Journal of Psychiatry 1996; 168: 93–100
   Web of Science ®Google Scholar
• Maier W, Minges J, Lichtermann D. Alcoholism and panic disorder: Co-occurrence and co-transmission in families. European Archives of Psychiatry Clinical Neurosciences 1993; 243: 205–211
   PubMedGoogle Scholar
• Mayes S, Calhoun S, Crites D. Does DSM-IV Asperger's disorder exist?. Journal of Abnormal Child Psychology 2001; 29: 263–271
   PubMed Web of Science ®Google Scholar
• McCauley JL, Li C, Jiang L, Olson LM, Crockett G, Gainer K, et al. Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Medical Genetics 2005; 12, 6:1
   Google Scholar
• McCauley JL, Olson LM, Delahanty R, Amin T, Nurmi EL, Organ EL, et al. A linkage disequilibrium map of the 1-Mb 15q12 GABA(A) receptor subunit cluster and association to autism. American Journal of Medical Genetics B Neuropsychiatric Genetics 2004; 131(1)51–59
   Google Scholar
• McGuffin P, Farmer AE, Gottesman II. Twin concordance for operationally defined schizophrenia: Confirmation of familiality and heritability. Archives of General Psychiatry 1984; 41: 541–545
   PubMed Web of Science ®Google Scholar
• Meaney MJ. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annals Review Neurosciences 2001; 24: 1161–1192
   PubMed Web of Science ®Google Scholar
• Merikangas KR. Comorbidity for anxiety and depression: A review of family and genetic studies. Comorbidity of mood and anxiety disorders, J. D. Maser, C. R. Cloninger. American Psychiatric Press, Washington DC 1990
   Google Scholar
• Merikangas KR. Editorial: The next decade of psychiatric epidemiology. International Journal of Methods Psychology Research 1999; 8: 1–5
   Google Scholar
• Merikangas KR, Avenevoli S, Dierker LC, Grillon C. Vulnerability factors among children at risk for anxiety disorders. Biological Psychiatry 1999; 46: 1523–1535
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Dierker L, Szatmari P. Psychopathology among offspring of parents with substance abuse and/or anxiety disorders: A high risk study. Journal of Child Psychology and Psychiatry 1998; 39: 711–720
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Risch N, Weissman MM. Comorbidity and co-transmission of alcoholism, anxiety, and depression. Psychological Medicine 1994; 24: 69–80
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Stevens DE. Models of transmission of substance use and comorbid psychiatric disorders. Dual diagnosis and treatment: Substance abuse and comorbid medical and psychiatric disorders, H. R. Kranzler, B. J. Rounsaville. Marcel Dekker Inc, New York 1998; 31–53
   Google Scholar
• Merikangas KR, Stevens DE, Fenton B, O’Malley S, Woods S, Stolar M, et al. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychological Medicine 1998; 28: 773–788
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig M, Fenton B, et al. Familial transmission of substance use disorders. Archives of General Psychiatry 1998; 55: 973–979
   PubMed Web of Science ®Google Scholar
• Merikangas KR, Swendsen J. The genetic epidemiology of psychiatric disorders. Epidemiological Review 1997; 19: 1–12
   Web of Science ®Google Scholar
• Macintosh KE, Dissanayake C. Annotation: The similarities and differences between autistic disorder and Asperger's disorder: A review of the empirical evidence. Journal of Child Psychology and Psychiatry 2004; 45: 421–434
   PubMed Web of Science ®Google Scholar
• Mulder EJ, Anderson GM, Kema IP, de Bildt A, van Lang ND, den Boer JA. Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. Journal of American Academy of Child and Adolescent Psychiatry 2004; 43: 491–499
   PubMed Web of Science ®Google Scholar
• Nurmi EL, Dowd M, Tadevosyan-Leyfer O, Haines JL, Folstein SE, Sutcliffe JS. Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13. Journal of American Academy of Child and Adolescent Psychiatry 2003; 42: 856–863
   PubMed Web of Science ®Google Scholar
• Pickens RW, Svikis DS, McGue M, La Buda MC. Common genetic mechanisms in alcohol, drug, and mental disorder comorbidity. Drug Alcohol Dependence 1995; 39: 129–138
   PubMed Web of Science ®Google Scholar
• Pickles A, Bolton P, Macdonald H, Bailey A, Le Couteur A, Sim CH, Rutter M. Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism. American Journal of Human Genetics 1995; 57: 717–726
   PubMed Web of Science ®Google Scholar
• Rabionet R, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS, Haines JL, et al. Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes. Neuroscience Letters 2004; 372(3)209–214
   PubMed Web of Science ®Google Scholar
• Reus VI, Freimer NB. Behavioral Genetics '97. Understanding the genetic basis of mood disorders: Where do we stand?. American Journal of Human Genetics 1997; 60: 1283–1288
   PubMedGoogle Scholar
• Risch N, Merikangas KR. The future of genetic studies of complex human diseases. Science 1996; 273: 1516–1517
   PubMed Web of Science ®Google Scholar
• Risch N. Mapping genes for psychiatric disorders. Genetic approaches to mental disorders, E. S. Gershon, C. R. Cloninger. American Psychiatric Press, Washington, DC 1994; 46–61
   Google Scholar
• Risch N, Spiker D, Lotspeich L, Nouri N, Hinds D, Hallmayer J, et al. A genomic screen of autism: Evidence for a multilocus etiology. American Journal of Human Genetics 1999; 65: 493–507
   PubMed Web of Science ®Google Scholar
• Risi S, Lord C, Corsello C, Chrysler C, Szatmari P, Cook EH. Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of American Academy of Child and Adolescent Psychiatry 2006; 45: 1094–1103
   PubMed Web of Science ®Google Scholar
• Ritvo ER, Freeman BJ, Mason-Brothers A, Mo A, Ritvo AM. Concordance for the syndrome of autism in 40 pairs of afflicted twins. The American Journal of Psychiatry 1985; 142: 74–77
   PubMed Web of Science ®Google Scholar
• Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. American Journal of Psychiatry 1970; 126: 983–987
   PubMed Web of Science ®Google Scholar
• Rothman KJ, Greenland S. Causation and causal inference in epidemiology. American Journal of Public Health 2005; 95(Suppl 1)S144–50
   PubMed Web of Science ®Google Scholar
• Rutter M, Le Couteur A, Lord C. Autism Diagnostic Interview-Revised–WPS. Western Psychological Services, Los Angeles 2003
   Google Scholar
• Schopler E. Are autism and Asperger syndrome (AS) different labels or different disabilities?. Journal of Autism and Developmental Disorders 1996; 26: 109–110
   PubMed Web of Science ®Google Scholar
• Shao Y, Raiford KL, Wolpert CM, Cope HA, Ravan SA, Ashley-Koch AA, et al. Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. American Journal of Human Genetics 2002; 70: 1058–1061
   PubMed Web of Science ®Google Scholar
• Shao Y, Cuccaro ML, Hauser ER, Raiford KL, Menold MM, Wolpert CM, et al. Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. American Journal of Human Genetics 2003; 72: 539–548
   PubMed Web of Science ®Google Scholar
• Silverman JM, Smith CJ, Schmeidler J, Hollander E, Lawlor BA, Fitzgerald M, et al. Symptom domains in autism and related conditions: Evidence for familiality. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2002; 114: 64–73
   Web of Science ®Google Scholar
• Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445(7130)881–885
   PubMed Web of Science ®Google Scholar
• Smoller JW, Tsuang M. Panic and phobic anxiety: Defining phenotypes for genetic studies. American Journal of Psychiatry 1998; 155: 1152–1162
   PubMed Web of Science ®Google Scholar
• Sparrow SS, Balla DA, Cicchetti DV. Vineland adaptive behavior scales (interview edition). American Guidance Service, Circle Pines, MN 1984
   Google Scholar
• Spiker D, Lotspeich LJ, Dimiceli S, Myers RM, Risch N. Behavioral phenotypic variation in autism multiplex families: Evidence for a continuous severity gradient. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2002; 114: 129–136
   Web of Science ®Google Scholar
• Spiker D, Lotspeich L, Kraemer HC, Hallmayer J, McMahon WM, Petersen PB, Nicholas P, Pingree C, Wiese-Slater S, Chiotti C, Wong DL, Dimicelli S, Ritvo E, Cavalli-Sforza LL, Ciaranello RD. Genetics of autism: Characteristics of affected and unaffected children from 37 multiplex families. American Journal of Medical Genetics (Neuropsychiatric Genetics) 1994; 54: 27–35
   Web of Science ®Google Scholar
• Steffenburg S, Gillberg C, Hellgren L, Andersson L, Gillberg IC, Jakobsson G, Bohman M. A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. Journal of Child Psychology and Psychiatry, and Allied Disciplines 1989; 30: 405–416
   PubMed Web of Science ®Google Scholar
• Sydenham T. Works … translated from the Latin edition of Dr. Greenhill by R. G. Latham, 2 volumes 1,13. Sydenham Society, London 1848
   Google Scholar
• Szatmari P, Jones MB, Holden J, Bryson S, Mahoney W, Tuff L, et al. High phenotypic correlations among siblings with autism and pervasive developmental disorders. American Journal of Medical Genetics (Neuropsychiatric Genetics) 1996; 67: 354–360
   Web of Science ®Google Scholar
• Szatmari P, Jones MB, Zwaigenbaum L, MacLean JE. Genetics of autism: Overview and new directions. Journal of Autism and Developmental Disorders 1998; 28: 351–368
   PubMed Web of Science ®Google Scholar
• Szatmari P, Bryson SE, Streiner DL, Wilson FJ, Archer L, Ryerse C. Two-year outcome of preschool children with autism or Asperger's syndrome. American Journal of Psychiatry 2000; 1576: 1980–1987
   Google Scholar
• Szatmari P, Archer L, Fisman S, Streiner D, Wilson F. Asperger's Syndrome and autism: Differences in behavior, cognition, and adaptive functioning. Journal of American Academy of Child and Adolescent Psychiatry 1995; 34: 1662–1671
   PubMed Web of Science ®Google Scholar
• Szatmari P, Merette C, Emond C, Zwaigenbaum L, Jones MB, Maziade M, et al. Decomposing the autism phenotype into familial dimensions. American Journal of Medical Genetics B Neuropsychiatric Genetics 2007, EPub, May
   PubMed Web of Science ®Google Scholar
• Szatmari P, Georgiades S, Bryson S, Zwaigenbaum L, Roberts W. Investigating the structure of the restricted, repetitive behaviours and interests domain of autism. Journal of Child Psychology and Psychiatry 2006; 47: 582–590
   PubMed Web of Science ®Google Scholar
• Szatmari P, Bryson SE, Boyle MH, Streiner DL, Duku E. Predictors of outcome among high functioning children with autism and Asperger syndrome. Journal of Child Psychology and Psychiatry 2003; 44: 520–528
   PubMed Web of Science ®Google Scholar
• Tadevosyan-Leyfer O, Dowd M, Mankoski R, Winklosky B, Putnam S, McGrath L, et al. A principal components analysis of the Autism Diagnostic Interview-Revised. Journal of the American Academy of Child and Adolescent Psychiatry 2003; 42: 864–872
   PubMed Web of Science ®Google Scholar
• Tsuang MT, Faraone SV, Lyons MJ. Identification of the phenotype in psychiatric genetics. European Archives of Psychiatry Clinical Neurosciences 1993; 243: 131–142
   PubMed Web of Science ®Google Scholar
• Tsuang MT. Defining alternative phenotypes for genetic studies: What can we learn from studies of schizophrenia?. American Journal of Medical Genetics 2001; 105(1)8–10
   PubMed Web of Science ®Google Scholar
• Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science 2001; 291(5507)1304–1351
   PubMed Web of Science ®Google Scholar
• Vieland VJ. Heterogeneity: GAW Group 15. Genetic Epidemiology 2005; 0(Suppl 1)S110–115
   Google Scholar
• Volkmar FR, Klin A, Siegel B, Szatmari P, Lord C, Campbell M, et al. Field trial for autistic disorder in DSM-IV. American Journal of Psychiatry 1994; 151: 1361–1367
   PubMed Web of Science ®Google Scholar
• Walker DR, Thompson A, Zwaigenbaum L, Goldberg J, Bryson SE, Mahoney WJ, et al. Specifying PDD-NOS: A comparison of PDD-NOS, Asperger syndrome, and autism. Journal of American Academy of Child and Adolescent Psychiatry 2004; 43: 172–180
   PubMed Web of Science ®Google Scholar
• Weissman MM, Merikangas KR, John K, Wickramaratne P, Prusoff BA, Kidd K. Family-genetic studies of psychiatric disorders: Developing technologies. Archives of General Psychiatry 1986; 43: 1104–1116
   PubMed Web of Science ®Google Scholar
• Wittchen HU, Zhao S, Kessler RC, Eaton WW. DSM-III-R generalized anxiety disorder in the National Comorbidity Survey. Archives of General Psychiatry 1994; 51: 355–364
   PubMed Web of Science ®Google Scholar
• Woodbury-Smith M, Klin A, Volkmar F. Asperger's Syndrome: A comparison of clinical diagnoses and those made according to the ICD-10 and DSM-IV. Journal of Autism and Developmental Disorders 2005; 35: 235–240
   PubMed Web of Science ®Google Scholar
• World Health Organization. The ICD-10 classification of mental and behavioral disorders: Clinical descriptions and diagnostic guidelines. World Health Organization, GenevaSwitzerland 1992
   Google Scholar