The effect of autophagy-enhancing peptide in moisturizer on atopic dermatitis: a randomized controlled trial

References

• Kezic S, Novak N, Jakasa I, et al. Skin barrier in atopic dermatitis. Front Biosci. 2014;19:542–556.
   Web of Science ®Google Scholar
• Kim DW, Park JY, Na GY, et al. Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis. Int J Dermatol. 2006;45:698–701.
   PubMed Web of Science ®Google Scholar
• Jakasa I, Verberk MM, Esposito M, et al. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol. 2007;127:129–134.
   PubMed Web of Science ®Google Scholar
• Gupta J, Grube E, Ericksen MB, et al. Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity. J Allergy Clin Immunol. 2008;121:725–730 e2.
   PubMed Web of Science ®Google Scholar
• Addor FA, Takaoka R, Rivitti EA, et al. Atopic dermatitis: correlation between non-damaged skin barrier function and disease activity. Int J Dermatol. 2012;51:672–676.
   PubMed Web of Science ®Google Scholar
• Elias PM, Steinhoff M. "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol. 2008;128:1067–1070. PubMed PMID: 18408746; PubMed Central PMCID: PMCPMC2675555.
   PubMed Web of Science ®Google Scholar
• Kezic S, Kemperman PM, Koster ES, et al. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol. 2008;128:2117–2119.
   PubMed Web of Science ®Google Scholar
• Krien PM, Kermici M. Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid. J Invest Dermatol. 2000;115:414–420.
   PubMed Web of Science ®Google Scholar
• Stefansson K, Brattsand M, Roosterman D, et al. Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol. 2008;128:18–25.
   PubMed Web of Science ®Google Scholar
• Elias PM, Hatano Y, Williams ML. Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol. 2008;121:1337–1343. PubMed PMID: 18329087; PubMed Central PMCID: PMCPMC2706021.
   PubMed Web of Science ®Google Scholar
• Brattsand M, Stefansson K, Lundh C, et al. A proteolytic cascade of kallikreins in the stratum corneum. J Invest Dermatol. 2005;124:198–203.
   PubMed Web of Science ®Google Scholar
• Ishikawa J, Narita H, Kondo N, et al. Changes in the ceramide profile of atopic dermatitis patients. J Invest Dermatol. 2010;130:2511–2514.
   PubMed Web of Science ®Google Scholar
• Janssens M, van Smeden J, Gooris GS, et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res. 2012;53:2755–2766. PubMed PMID: 23024286; PubMed Central PMCID: PMCPMC3494247.
   PubMed Web of Science ®Google Scholar
• Jungersted JM, Scheer H, Mempel M, et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy. 2010;65:911–918.
   PubMed Web of Science ®Google Scholar
• Chamlin SL, Kao J, Frieden IJ, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002;47:198–208.
   PubMed Web of Science ®Google Scholar
• Cork MJ, Britton J, Butler L, et al. Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse. Br J Dermatol. 2003;149:582–589.
   PubMed Web of Science ®Google Scholar
• Loden M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4:771–788.
   PubMed Web of Science ®Google Scholar
• Na JI, Hwang JS, Park HJ, et al. A new moisturizer containing physiologic lipid granules alleviates atopic dermatitis. J Dermatolog Treat. 2010;21:23–27.
   PubMed Web of Science ®Google Scholar
• Simpson E, Bohling A, Bielfeldt S, et al. Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J Dermatolog Treat. 2013;24:122–125.
   PubMed Web of Science ®Google Scholar
• Bissonnette R, Maari C, Provost N, et al. A double-blind study of tolerance and efficacy of a new urea-containing moisturizer in patients with atopic dermatitis. J Cosmet Dermatol. 2010;9:16–21.
   PubMed Web of Science ®Google Scholar
• Soma Y, Kashima M, Imaizumi A, et al. Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005;44:197–202.
   PubMed Web of Science ®Google Scholar
• Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010;12:814–822. PubMed PMID: 20811353; PubMed Central PMCID: PMCPMC3616322.
   PubMed Web of Science ®Google Scholar
• Heath RJ, Xavier RJ. Autophagy, immunity and human disease. Curr Opin Gastroenterol. 2009;25:512–520. PubMed PMID: 19826372; PubMed Central PMCID: PMCPMC2849745.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, Inflammation, and Immunity: a Troika governing cancer and its treatment. Cell. 2016;166:288–298. PubMed PMID: 27419869; PubMed Central PMCID: PMCPMC4947210.
   PubMed Web of Science ®Google Scholar
• Qian M, Fang X, Wang X. Autophagy and inflammation. Clin Transl Med. 2017;6:24. PubMed PMID: 28748360; PubMed Central PMCID: PMCPMC5529308.
   PubMed Web of Science ®Google Scholar
• Haruna K, Suga Y, Muramatsu S, et al. Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes. J Dermatol Sci. 2008;52(3):213–215. doi: 10.1016/j.jdermsci.2008.07.005. PubMed PMID: 18760570.
   PubMed Web of Science ®Google Scholar
• Chatterjea SM, Resing KA, Old W, et al. Optimization of filaggrin expression and processing in cultured rat keratinocytes. J Dermatol Sci. 2011;61:51–59. PubMed PMID: 21146962; PubMed Central PMCID: PMCPMC3031422.
   PubMed Web of Science ®Google Scholar
• Kloft N, Neukirch C, Bobkiewicz W, et al. Pro-autophagic signal induction by bacterial pore-forming toxins. Med Microbiol Immunol. 2010;199:299–309. PubMed PMID: 20454906; PubMed Central PMCID: PMCPMC2955911.
   PubMed Web of Science ®Google Scholar
• Pai VV, Bhandari P, Shukla P. Topical peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017;83:9–18.
   PubMed Web of Science ®Google Scholar
• Schagen SK. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017;4:16.
   Google Scholar
• Severity scoring of atopic dermatitis: the SCORAD index. Consensus report of the European task force on atopic dermatitis. Dermatology. 1993;186:23–31.
   PubMed Web of Science ®Google Scholar
• Reich A, Heisig M, Phan NQ, et al. Visual analogue scale: evaluation of the instrument for the assessment of pruritus. Acta Derm Venerol. 2012;92:497–501.
   PubMed Web of Science ®Google Scholar
• Kuballa P, Nolte WM, Castoreno AB, et al. Autophagy and the immune system. Annu Rev Immunol. 2012;30:611–646.
   PubMed Web of Science ®Google Scholar
• Shoji-Kawata S, Sumpter R, Leveno M, et al. Identification of a candidate therapeutic autophagy-inducing peptide. Nature. 2013;494:201–206. PubMed PMID: 23364696; PubMed Central PMCID: PMCPMC3788641.
   PubMed Web of Science ®Google Scholar
• Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov. 2012;11:709–730. PubMed PMID: 22935804; PubMed Central PMCID: PMCPMC3518431.
   PubMed Web of Science ®Google Scholar
• Blunder S, Koks S, Koks G, et al. Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with Ichthyosis vulgaris. J Invest Dermatol. 2018;138:98–108.
   PubMed Web of Science ®Google Scholar
• Elias PM, Wakefield JS. Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol. 2014;134:781–791 e1. PubMed PMID: 25131691; PubMed Central PMCID: PMCPMC4186911.
   PubMed Web of Science ®Google Scholar
• Raymond AA, Gonzalez de Peredo A, Stella A, et al. Lamellar bodies of human epidermis: proteomics characterization by high throughput mass spectrometry and possible involvement of CLIP-170 in their trafficking/secretion. Mol Cell Proteomics. 2008;7:2151–2175.
   PubMed Web of Science ®Google Scholar
• Mostowy S, Sancho-Shimizu V, Hamon MA, et al. p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem. 2011;286:26987–26995. PubMed PMID: 21646350; PubMed Central PMCID: PMCPMC3143657.
   PubMed Web of Science ®Google Scholar
• Hartman ML, Kornfeld H. Interactions between naive and infected macrophages reduce Mycobacterium tuberculosis viability. PLoS One. 2011;6:e27972. PubMed PMID: 22125644; PubMed Central PMCID: PMCPMC3220711.
   PubMed Web of Science ®Google Scholar
• Harris J, De Haro SA, Master SS, et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity. 2007;27:505–517.
   PubMed Web of Science ®Google Scholar
• Lim CJ, Lee YM, Kang SG, et al. Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis. Biomol Ther (Seoul). 2017;25:511–518. PubMed PMID: 28822991; PubMed Central PMCID: PMCPMC5590795.
   PubMed Web of Science ®Google Scholar
• Lapaquette P, Guzzo J, Bretillon L, et al. Cellular and molecular connections between autophagy and inflammation. Mediators Inflamm. 2015;2015:1. PubMed PMID: 26221063; PubMed Central PMCID: PMCPMC4499609.
   Web of Science ®Google Scholar
• Fu Y, Chang H, Peng X, et al. Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/beta-catenin signaling pathway. PLoS One. 2014;9:e102535. PubMed PMI D: 25068516; PubMed Central PMCID: PMCPMC4113212.
   PubMed Web of Science ®Google Scholar
• Jeong S, Lee SH, Park BD, et al. Comparison of the efficacy of atopalm((R)) multi-lamellar emulsion cream and physiogel((R)) intensive cream in improving epidermal permeability barrier in sensitive skin. Dermatol Ther (Heidelb). 2016;6:47–56. PubMed PMID: 26841947; PubMed Central PMCID: PMCPMC4799034.
   PubMed Web of Science ®Google Scholar
• Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008;456:264–268.
   PubMed Web of Science ®Google Scholar
• Nakahira K, Haspel JA, Rathinam VA, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12:222–230. PubMed PMID: 21151103; PubMed Central PMCID: PMCPMC3079381.
   PubMed Web of Science ®Google Scholar
• Gross O, Thomas CJ, Guarda G, et al. The inflammasome: an integrated view. Immunol Rev. 2011;243:136–151.
   PubMed Web of Science ®Google Scholar
• Shi CS, Shenderov K, Huang NN, et al. Activation of autophagy by inflammatory signals limits IL-1beta production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol. 2012;13:255–263. PubMed PMID: 22286270; PubMed Central PMCID: PMCPMC4116819.
   PubMed Web of Science ®Google Scholar
• Harris J, Hartman M, Roche C, et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem. 2011;286:9587–9597. PubMed PMID: 21228274; PubMe. C, entral PMCID: PMCPMC3058966.
   PubMed Web of Science ®Google Scholar
• Haruna K, Suga Y, Muramatsu S, et al. Differentiation-specific expression and localization of an autophagosomal marker protein (LC3) in human epidermal keratinocytes. J Dermatol Sci. 2008;52:213–215.
   PubMed Web of Science ®Google Scholar
• Wang RC, Levine B. Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011;131:990–993. PMID: 21228817; PubMed Central PMCID: PMCPMC3131686.
   PubMed Web of Science ®Google Scholar
• Sukseree S, Eckhart L, Tschachler E, et al. Autophagy in epithelial homeostasis and defense. Front Biosci (Elite Ed). 2013;5:1000–1010.
   PubMedGoogle Scholar
• Henault J, Martinez J, Riggs JM, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. 2012;37:986–997. PubMed PMID: 23219390; PubMed Central PMCID: PMCPMC3786711.
   PubMed Web of Science ®Google Scholar
• Nedjic J, Aichinger M, Emmerich J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature. 2008;455:396–400.
   PubMed Web of Science ®Google Scholar
• Shi CS, Kehrl JH. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal. 2010;3:ra42.
   PubMed Web of Science ®Google Scholar
• Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010;16:90–97.
   PubMed Web of Science ®Google Scholar
• Franco LH, Fleuri AKA, Pellison NC, et al. Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection. J Biol Chem. 2017;292:13087–13096. PubMed PMID: 28607148; PubMed Central PMCID: PMCPMC5555173.
   PubMed Web of Science ®Google Scholar
• Agrawal V, Jaiswal MK, Mallers T, et al. Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor. Sci Rep. 2015;5:9410. PubMed PMID: 25797357; PubMed Central PMCID: PMCPMC4369745.
   PubMed Web of Science ®Google Scholar