Human mesenchymal stem cell-derived exosomes accelerate wound healing of mice eczema

References

• Odhiambo JA, Williams HC, Clayton TO, et al. Global variations in prevalence of eczema symptoms in children from ISAAC phase three. J Allergy Clin Immunol. 2009;124(6):1251–1258.
   PubMed Web of Science ®Google Scholar
• Brown SJ, Relton CL, Liao H, et al. Filaggrin null mutations and childhood atopic eczema: a population-based case-control study. J Allergy Clin Immunol. 2008;121(4):940–946.
   PubMed Web of Science ®Google Scholar
• Weidinger S, Beck LA, Bieber T, et al. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1.
   PubMed Web of Science ®Google Scholar
• Verhagen J, Akdis M, Traidl-Hoffmann C, et al. Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol. 2006;117(1):176–183.
   PubMed Web of Science ®Google Scholar
• Ismail IH, Boyle RJ, Mah LJ, et al. Reduced neonatal regulatory T cell response to microbial stimuli associates with subsequent eczema in high-risk infants. Pediatr Allergy Immunol. 2014;25(7):674–684.
   PubMed Web of Science ®Google Scholar
• Hijnen D, Haeck I, van Kraats AA, et al. Cyclosporin A reduces CD4(+)CD25(+) regulatory T-cell numbers in patients with atopic dermatitis. J Allergy Clin Immunol. 2009;124(4):856–858.
   PubMed Web of Science ®Google Scholar
• Eyerich K, Eyerich S. Immune response patterns in non-communicable inflammatory skin diseases. J Eur Acad Dermatol Venereol. 2018;32(5):692–703.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Fu L, Liang Y, et al. Exosomes originating from MSCs stimulated with TGF-β and IFN-γ promote Treg differentiation. J Cell Physiol. 2018;233(9):6832–6840.
   PubMed Web of Science ®Google Scholar
• Castro-Manrreza ME, Montesinos JJ. Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications. J Immunol Res. 2015;2015:394917.
   PubMed Web of Science ®Google Scholar
• Jan AT, Rahman S, Khan S, et al. Biology, pathophysiological role, and clinical implications of exosomes: a critical appraisal. Cells-Basel. 2019;8(2):99.
   Web of Science ®Google Scholar
• Wen S, Dooner M, Cheng Y, et al. Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells. Leukemia. 2016;30(11):2221–2231.
   PubMed Web of Science ®Google Scholar
• Ward MR, Abadeh A, Connelly KA. Concise review: rational use of mesenchymal stem cells in the treatment of ischemic heart disease. Stem Cells Transl Med. 2018;7(7):543–550.
   PubMed Web of Science ®Google Scholar
• Varkouhi AK, Jerkic M, Ormesher L, et al. Extracellular vesicles from interferon-γ-primed human umbilical cord mesenchymal stromal cells reduce Escherichia coli-induced acute lung injury in rats. Anesthesiology. 2019;130(5):778–790.
   PubMed Web of Science ®Google Scholar
• Sun X, Meng H, Wan W, et al. Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases. Stem Cell Res Ther. 2019;10(1):8.
   PubMedGoogle Scholar
• Lopez-Verrilli MA, Caviedes A, Cabrera A, et al. Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth. Neuroscience. 2016;320:129–139.
   PubMed Web of Science ®Google Scholar
• Dongmei H, Jing L, Mei X, et al. Clinical analysis of the treatment of spinocerebellar ataxia and multiple system atrophy-cerebellar type with umbilical cord mesenchymal stromal cells. Cytotherapy. 2011;13(8):913–917.
   PubMed Web of Science ®Google Scholar
• Harada D, Takada C, Tsukumo Y, et al. Analyses of a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application. J Dermatol Sci. 2005;37(3):159–167.
   PubMed Web of Science ®Google Scholar
• Novak N, Bieber T, Hoffmann M, et al. Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol. 2012;130(4):925–931.
   PubMed Web of Science ®Google Scholar
• Roekevisch E, Spuls PI, Kuester D, et al. Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review. J Allergy Clin Immunol. 2014;133(2):429–438.
   PubMed Web of Science ®Google Scholar
• Brown S, Reynolds NJ. Atopic and non-atopic eczema. BMJ. 2006;332(7541):584–588.
   PubMedGoogle Scholar
• Darsow U, Wollenberg A, Simon D, et al. Difficult to control atopic dermatitis. World Allergy Organ J. 2013;6(1):6.
   PubMedGoogle Scholar
• Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514.
   PubMed Web of Science ®Google Scholar
• Faruqu FN, Wang JT, Xu L, et al. Membrane radiolabelling of exosomes for comparative biodistribution analysis in immunocompetent and immunodeficient mice – a novel and universal approach. Theranostics. 2019;9(6):1666–1682.
   PubMed Web of Science ®Google Scholar
• Sokolova V, Ludwig AK, Hornung S, et al. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy. Colloids Surf B Biointerfaces. 2011;87(1):146–150.
   PubMed Web of Science ®Google Scholar
• Mohr A, Atif M, Balderas R, et al. The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases. Clin Exp Immunol. 2019;197(1):24–35.
   PubMed Web of Science ®Google Scholar
• Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736–1743.
   PubMed Web of Science ®Google Scholar
• Zhang J, Chen C, Hu B, et al. Exosomes derived from human endothelial progenitor cells accelerate cutaneous wound healing by promoting angiogenesis through Erk1/2 signaling. Int J Biol Sci. 2016;12(12):1472–1487.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang M, Gong A, et al. HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing. Stem Cells. 2015;33(7):2158–2168.
   PubMed Web of Science ®Google Scholar
• Hu Y, Rao SS, Wang ZX, et al. Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function. Theranostics. 2018;8(1):169–184.
   PubMed Web of Science ®Google Scholar