211
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells

, &
Pages 397-408 | Received 04 Jul 2004, Accepted 13 Apr 2005, Published online: 03 Jul 2009

References

  • Adams GE:. 1973. Chemical radiosensitization of hypoxic cells. British Medical Bulletin 29: 48–53.
  • Aft RL,, Zhang FW, Guis D. 2002. Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent; Mechanism of cell death. British Journal of Cancer 87: 805–812.
  • Akagi Y, Ito K, Swada S. 1995. Radiation induced apoptosis and necrosis in molt4 cells, a study of dose effect relationship and their modification. International Journal of Radiation Biology 64: 47–56.
  • Ames MM, Walker DL, Reid JM, Svingen PA, Budhihardjo I, Kaufmann SH, Covey JM, Alley MC, Hollingshed MG. 1996. 6-aminonicotinamide: murine plasma pharmacokinetics and modulation of drug resistance. Proceedings of the American Association of Cancer Research 37: 1965.
  • Dwarakanath BS. 1988. Energy metabolism and repair of radiation induced damage in brain tumours. PhD thesis, Bangalore University.
  • Dwarakanath BS, Adhikari JS, Jain V. 1999. Hematoporphyrin derivatives potentiates the radiosensitizing effects of 2 deoxy-D-glucose in cancer cells. International Journal of Radiation Oncology Biology and Physics 43: 1125–1133.
  • Dwarakanath BS, Jain VK. 1987. Modification of radiation induced damage by 2-deoxy-D-glucose in organ cultures of human cerebral glioma. International Journal of Radiation Oncology Biology and Physics 13: 741–746.
  • Dwarakanath BS, Jain VK. 1989. Energy linked modification of the radiation response in a human cerebral glioma cell line. International Journal of Radiation Oncology Biology and Physics 17: 1033–1040.
  • Dwarakanath BS, Jain VK. 1991. Effects of gamma-rays and glucose analogue on the energy metabolism of cell line derived from cerebral glioma. Indian Journal of Biochemistry and Biophysics 28: 203–209.
  • Dwarakanath BS, Zolzer F, Chandana S, Bauch T, Adhikari JS, Muller W, Streffer C, Jain V. 2001. Heterogeneity in 2-deoxy-D-glucose induced modification of radiation response in human tumour cell lines. International Journal of Radiation Oncology Biology and Physics 50: 1051–1061.
  • Gilbertz KP, Baaske C, Van Beuningen D. 1993. Cell kinetic analysis after irradiation in L929- and LLC-MK2 cou by a BrdU/DNA assay. Strahlentherapie und Onkologie 169: 187–195.
  • Hendry JH, West CML. 1997. Apoptosis and mitotic cell death: their relative contributions to normal tissue and tumour radiosensitivity. International Journal of Radiation Biology 71: 709–720.
  • Herter FP, Weissman SG, Thompson HG, Hyman G, Martin DS. 1961. Clinical experience with 6-aminonicotinamide. Cancer Research 21: 31–37.
  • Hissin PJ, Hilf R. 1976. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry 74: 214–226.
  • Hunting D, Gowans B, Hendason JF. 1985. Effects of 6-AN on cell growth, poly (ADP-ribose) synthesis and nucleotide metabolism. Biochemical Pharmacology 34: 3999–4003.
  • Jain V, Pohlit W, Purohit SC. 1973. Influence of energy metabolism on the repair of x-ray damage in living cells. III. Effects of 2-deoxy-D-glucose on the liquid holding reactivation in yeast. Biophysik 10: 137–142.
  • Jain V, Pohlit W. 1972. Influence of energy metabolism on the repair of x-ray damage in living cells. I. Effects of respiratory inhibitors and glucose on the liquid-holding reactivation in yeast. Biophysik 8: 254–263.
  • Jain V, Porschen W, Feinendegen LE. 1977a. Optimization of cancer therapy: Part II. Effects of combining 2-deoxy-D-glucose treatment with gamma irradiation on sarcoma-180. Indian Journal of Experimental Biology 15: 714–718.
  • Jain VK, Holtz GW, Pohlit W, Purohit SC. 1977b. Inhibition of unscheduled DNA synthesis and repair of potentially lethal x-ray damage by 2-deoxy-D-glucose in yeast. International Journal of Radiation Biology 32: 175–180.
  • Jain VK, Kalia VK, Gopinath PM. 1979. Optimization of cancer therapy, part III. Effects of combining 2-deoxy-D-glucose treatment with gamma irradiation on normal mice, Indian Journal of Experimental Biology 17: 1320–1325.
  • Jain VK, Kalia VK, Sharma R, Maharajan V, Menon M. 1985. Effects of 2-deoxy-D-glucose on glycolysis, proliferation kinetics and radiation response of human cancer cells. International Journal of Radiation Oncology Biology and Physics 11: 943–950.
  • Jeggo PA. 1998. DNA repair: PARP-another guardian angel? Current Biology 8: R49–R51.
  • Jha B, Pohlit W. 1992. Effects of 2-deoxy-D Glucose on DNA double strand break repair, cell survival and energy metabolism in euoxic Ehrlich ascites tumour cells. International Journal of Radiation Biology 62: 409–415.
  • Jha B, Pohlit W. 1993. Reversibility of inhibition of DNA double strand break repair by 2-deoxy-D-glucose in Ehrlich ascites tumour cells. International Journal of Radiation Biology 63: 459–467.
  • Kahana SE, Lowry OH, Schulz DW, Passonneau JV, Carwford EJ. 1960. The kinetics of phospho glucasei somerase. Journal of Biological Chemistry 235: 2178–2184.
  • Kalia VK, Jain VK, Otto FJ. 1982. Optimization of cancer therapy IV. Effects of 2-deoxy-D-glucose on radiation induced chromosomal damage in PHA stimulated peripheral leuko-cytes. Indian Journal of Experimental Biology 20: 884–888.
  • Kasid U, Pirollo K, Dritschilo A, Chang E. 1993. Oncogenic basis of radioresistance. Advances in Cancer Research 61: 195–233.
  • Keniry MA, Hollander C, Benz CC. 1989. The effect of gossypal and 6-aminonicotinamide on tumour cell metabolism: a magnetic resonance resonance spectroscopic study. Biochemical and Biophysical Research Communication 164: 947–953.
  • Krepinsky A, Heddle J. 1983. In: Ishihara T, Sasaki MS, editors. Radiation induced chromosome damage in man. New York: Alan R. Liss. p. 93–109.
  • Landau BR, Laszlo J, Stengle J, Bruk D. 1958. Certain metabolic and pharmacological effects in cancer patients given infusion of 2-deoxy-D-glucose. Journal of the National Cancer Institute 21: 485–494.
  • Life Sciences Update. 2001. Breast cancer therapy enhancement by 6-aminonicotinamide. Internet site www.fmdarticles.com/p/ articles/mi-MODFY/is-8-2001/ai–7702180.
  • Maga G, Hubscher U. 2003. Proliferating cell nuclear antigen (PCNA) a dancer with many partners. Journal of Cell Science 116: 3051–3060.
  • Majka J, Chung BY, Burgers MJ. 2004. Requirement for ATP by the DNA damage checkpoint clamp loader. Journal of Biological Chemistry 279: 20921–20926.
  • Meldrum BS, Horton RW. 1973. Cerebral functional effects of 2-DG and 3-0-methylglucose in Rhesus monkeys. EEG and Clinical Neurophysiology 35: 59–66.
  • Miller AC, Gather J, Clark EP, Samid D. 1993. Posttranscrip-tional down regulation of ras oncogene expression by inhibitors of cellular glutathione. Molecular Cell Biology 13: 4416–4422.
  • Mitchell JB, Russo A. 1987. The role of glutathione in radiation and during cytotoxicity. British Journal of Cancer 55(Suppl. VIII): 96–104.
  • Mohanti BK, Rath GK, Anantha N, Kannan V, Das BS, Chandramouli AR, Banerjee AK, Das S, Jena A, Ravichandran R, Sahi UP, Kumar R, Kapoor N, Kalia VK, Dwarakanath BS, Jain V. 1996. Improving cancer radiotherapy with 2-deoxy-D-glucose: Phase I/II clinical trials on human cerebral gliomas. International Journal of Radiation Oncology Biology and Physics 35: 103–111.
  • Morales A, Miranda M, Sanchez-Reys A, Biete A, Fanandez-Checa JC. 1998. Oxidative days of mitochondria and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells. International Journal of Radiation Oncology Biology and Physics 42: 191–203.
  • Paglin S, Delohery T, Erlandson R, Yahalom J. 1997. Radiation induced micronuclei formation in human breast cancer cells: Dependence on serum and cell cycle distribution. Biochemical and Biophysical Research Communications 237: 678–684.
  • Paunesko T, Mittal S, Protic M, Oryhon J, Korolev SV, Joachimiak A, Woloschak GE. 2001. Proliferating cell nuclear antigen (PCNA): ringmaster of the genome. International Journal of Radiation Biology 77: 1007–1021.
  • Prosperi E. 1997. Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control. Progress in Cell Cycle Research 30: 193–210.
  • Purohit SC, Pohlit W. 1982. Experimental evaluation of the glucose antimetabolite. 2-Deoxy-D glucose (2-DG) as a possible adjuvant to radiotherapy of tumours. I Kinetics of growth and survival of Ehrlich ascites tumour cells (EATC) in vitro and growth of solid tumours after 2-DG and X irradiation. International Journal of Radiation Oncology Biology and Physics 8: 495–499.
  • Schutte B, Reynders MMJ, Van Assche CLMVJ, Hupperets PSGJ, Bosman FT, Blijham GH. 1987. An improved method for the immunocytomertry detection of bromodeoxyuridine labeled nuclei using flow cytometry. Cytometry 8: 372–376.
  • Sharma RK, Hansum H, Jain V. 2000. NMR spectroscopic studies on the bioenergetic changes induced by metabolic modulators in Ehrlich ascites tumour cells. Indian Journal of Biochemistry and Biophysics 37: 307–312.
  • Singh D, Banerjee AK, Dwarakanath BS, Tripathi RP, Gupta JP, Mathew TL, Ravindranath T, Jain V. 2005. Optimizing cancer radiotherapy with 2-deoxy-D-glucose :dose escalation studies in patients with cerebral glioblastoma multiforme. Strah-lentherapie (in press).
  • Singh SP, Singh S, Jain V. 1990. Effects of 5-bromo-deoxy-uridine and 2-deoxy-D-glucose on radiation-induced micronuclei in mouse bone marrow. International Journal of Radiation Biology 58: 791–797.
  • Smulson MF, Schein P, Mullins DW, Sudhakar S. 1977. A putative role for nicotinamide adenine dinucleotide promoted nuclear protein modification in the antitumor activity of N methylnitosourea. Cancer Research 37: 3006–3012.
  • Steel GG:. 2001. The case against apoptosis. Acta Oncologica 40: 968–975.
  • Street JC, Alferi AA, Koutcher JA. 1997. Quantitation of metabolic and radiobiological effects of 6-aminonicotinamide in RIF-1 tumour cells in vitro. Cancer Research 57: 3956–3962.
  • Street JC, Mahmood U, Ballon D, Alfieri AA, Koutcher JA. 1996. 13C and 31 P NMR investigation of effect of 6-aminonicotina-mide on metabolism of RIF-1 tumour cells in vitro. Journal of Biological Chemistry 271: 4113–4119.
  • Suit HD, Baumann M, Skates S, Convery K. 1989. Clinical interest in determinations of cellular radiosensitivity. Interna-tional Journal of Radiation Biology 56: 725–737.
  • Thompson DA, Campbell RG, Lilavivavathana U. 1981. In-creased thirst and plasma arginine vasopressin levels during 2-DG induced glucodeprivation in humans. Journal of Clinical Investigation 67: 1083–1093.
  • Varshney R, Adhikari JS, Dwarakanath BS. 2003. Contribution of oxidative stress to radiosensitization by a combination of 2-DG and 6-AN in human cancer cell line. Indian Journal of Experimental Biology 41: 1384–1391.
  • Varshney R, Gupta S, Dwarakanath BS. 2004. Radiosensitization of Murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide. Technology in Cancer Research 3: 659–663.
  • Varshney R, Kale RK. 1990. Effects of calmodulin antagonists on radiation induced lipid peroxidation in microsomes. Interna-tional Journal of Radiation Biology 58: 733–743.
  • Varshney R, Kale RK. 1996. Physico-chemical pathways in radioprotective action of calmodulin antagonists. Radiation Physics and chemistry 47: 595–599.
  • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsoerger C. 1995. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled detection. Journal of Immunology Methods 184: 39–51.
  • Walker DL, Reid JM, Svingen PA, Rios R, Covey JM, Alley MC, Hollingshed MG, Budihardjo II, Eckdahl S, Boemer SA, Kaufmann SH, Ames MM. 1999. Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Biochemical Pharmacology 58: 1057–1066.
  • Weichselbaum RR, Beckett MA, Schwartz JL, Dritchilo A. 1988. A radioresistant tumour cells are present in head and neck carcinoma that recurs after irradiation. International Journal of Radiation Oncology Biology and Physics 15: 575–579.
  • Wick AN, Dury D, Nakada HI, Wolfe JB. 1957. Localization of the primary metabolic block produced by 2-deoxy-D glucose. Journal of Biological Chemistry 224: 963–969.
  • Woodward GE, Cramer FB. 1952. 2-Deoxy-D-glucose as an inhibitor of anaerobic glycolysis in tumour tissue. Journal of the Franklin Institute 254: 259–260.
  • Yuhas JM, Spellman JM, Cub o F. 1980. The role of WR-2721 in radiotherapy and/or chemotherapy. Cancer Clinical Trials 3: 211— 216.
  • Zolzer F, Hilerbrandt S, Streffer C. 1995. Radiation-induced G1 block and p53 status in six human cell lines. Radiotherapy Oncology 37: 20–28.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.