Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model

References

• Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Molecular Biology and Medicine 1990; 7: 147–159
   PubMedGoogle Scholar
• Bellido T, O'Brien C A, Roberson P K, Manolagas S C. Transcriptional activation of the p21 (WAF1, CIP1, SDI1) gene by interleukin-6 type cytokines: A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. Journal of Biological Chemistry 1998; 273: 21137–21144
   PubMed Web of Science ®Google Scholar
• Bender M A, Awa A A, Brooks A L, Evans H J, Groer P G, Littlefield L G, Pereira C, Preston R J, Wachholz B W. Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Research 1988; 196: 103–159
   PubMed Web of Science ®Google Scholar
• Blakely W F, Miller A C, Grace M B, McLeland C B, Luo L, Muderhwa J M, Miner V L, Prasanna P G. Radiation biodosimetry: Applications for spaceflight. Advances in Space Research 2003; 31(6)1487–1493
   PubMedGoogle Scholar
• Blakely W F, Miller A C, Muderhwa J M, Manglapus G L, Leidel J M, Martinez M, Landauer M R, Grace M B, Prasanna P G (2005b) Development and validation of radiation-responsive protein bioassays for biodosimetry applications. Published in the proceedings of North Atlantic Treaty Organization (NATO) Human Factors and Medicine (HFM) Panel Research Task Group (RTG) 099 Meeting. “Radiation Bioeffects and Countermeasures”, Bethesda, MDUSA, June, 21–232005, Compact disc: AFRRI CD 05-2
   Google Scholar
• Blakely WF, Ossetrova NI, Grace MB, Miller AC, Muderhwa JM, Manglapus GL. Biomarker Panels for Assessing Radiation Injury and Exposure. 2007b, HJF 134-05, WH 2001797. 121. PCT/US2007/013752
   Google Scholar
• Blakely W F, Ossetrova N I, Manglapus G L, Levine I H, Jackson W E, Grace M B, Prasanna P GS, Sandgren D J, Ledney G D. Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model – use of multiparameter and integrated biological dosimetry. Radiation Measurements 2007; 42: 1164–1170
   Web of Science ®Google Scholar
• Blakely W F, Prasanna P G, Grace M B. Radiation exposure assessment using cytological and molecular biomarkers. Radiation Protection Dosimetry 2001; 97: 17–23
   PubMed Web of Science ®Google Scholar
• Blakely W F, Salter C A, Prasanna P G. Early-response biological dosimetry – recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Physics 2005a; 89(5)494–504
   PubMed Web of Science ®Google Scholar
• Brooks A L. Biomarkers of exposure, sensitivity and disease. International Journal of Radiation Biology 1999; 75: 1481–1503
   PubMed Web of Science ®Google Scholar
• Brooks A L. Biomarkers of exposure and dose: State of the art. Radiation Protection Dosimetry 2001; 97: 39–46
   PubMed Web of Science ®Google Scholar
• Christiansen H, Sheikh N, Saile B, Reuter F, Rave-Fränk M, Hermann R, Dudas J, Hille A, Hess C F, Ramadori G. X-irradiation in rat liver: Consequent upregulation of hepcidin and downregulation of hemojuvelin and ferroportin-1 gene expression. Radiology 2007; 242: 189–197
   PubMed Web of Science ®Google Scholar
• Coleman M A, Yin E, Sorensen K, Marsh B J, Mabery S, Tomascik-Cheeseman L, Liu S, Gregg J P, Mascio-Kegelmeyer L, Wyrobek A J. Radiation-induced changes in the expression of stress response and DNA repair genes in human and mouse cells. American Journal of Human Genetics 2000; 67(Suppl.)191–191
   Google Scholar
• Dainiak N, Waselenko J K, Armitage J O, MacVittie T J, Farese A M. The hematologist and radiation casualties. Hematology/the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003; 2003: 473–496
   Google Scholar
• Dressman H K, Muramoto G G, Chao N J, Meadows S, Marshall D, Ginsburg G S, Nevins J R, Chute J P. Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med 2007; 4: e106
   PubMed Web of Science ®Google Scholar
• Eguchi-Kasai K, Kosaka T, Sato K, Kaneko I. Reparability of DNA double strand breaks and radiation sensitivity in 5 mammalian cell lines. International Journal of Radiation Biology 1991; 59: 97–104
   PubMed Web of Science ®Google Scholar
• Hong Y, Stambrook P. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proceedings of the National Academy of Sciences of the USA 2004; 101: 14443–14448
   PubMed Web of Science ®Google Scholar
• Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. The New England Journal of Medicine 1999; 340(6)448–454
   PubMed Web of Science ®Google Scholar
• Gartel A L, Tyner A L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Molecular Cancer Therapeutics 2002; 1: 639–649
   PubMed Web of Science ®Google Scholar
• Goans R E, Holloway E C, Berger M E, Ricks R C. Early dose assessment following severe radiation accidents. Health Physics 1997; 72: 513–518
   PubMed Web of Science ®Google Scholar
• Goltry K L, Epperly M W, Greenberger J S. Induction of serum amyloid A inflammatory response genes in irradiated bone marrow cells. Radiation Research 1998; 149(6)570–578
   PubMed Web of Science ®Google Scholar
• Kalechman Y, Shani A, Albeck M, Sredni B. Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties. Immunopharmacology 1995; 29(2)149–158
   PubMedGoogle Scholar
• Khattree R, Naik D. Multivariate data reduction and discrimination with SAS Software, SAS Institute Inc. SAS Press and John Wiley Sons Inc, Cary, NC 2000
   Google Scholar
• Kishimoto T. The biology of interleukin 6. Blood 1989; 74: 1–10
   PubMed Web of Science ®Google Scholar
• Kovalev E E, Smirnova O A. Estimation of radiation risk based on the concept of individual variability of radiosensitivity. Contract Report CR96-1, ADA310666. Armed Forces Radiobiology Research Institute, Bethesda, MD 1996
   Google Scholar
• LeMotte P, Little J. A comparison of the lethal effects of intracellular radionuclides in human and rodent cells. Radiation Research 1983; 95: 359–369
   PubMed Web of Science ®Google Scholar
• MacVittie T J, Farese A M, Patchen M L, Myers L A. Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a non-human primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood 1994; 84: 2515–2522
   PubMed Web of Science ®Google Scholar
• Malashenko A M, Beskova T B, Pomerantseva M D, Ramaiya L K. Comparison of three inbred mouse strains with respect to general and genetic radiosensitivity. Russian Journal of Genetics 2003; 39: 1052–1055
   Google Scholar
• Mal'tsev V N, Strel'nikov V A, Ivanov A A. C-reactive protein in the blood serum as an indicator of the severity of radiation lesion. Doklady Akademii Nauk SSR 1978; 239(3)750–752
   PubMedGoogle Scholar
• Mal'tsev V N, Ivanov A A, Mikhailov V F, Mazurik V K. The individual prognosis of the gravity of the outcome of radiation disease on immunological indexes. Radiatsionnaia Biologiia, Radioecologiia 2006; 46(2)152–158
   PubMedGoogle Scholar
• Marchetti F, Coleman M A, Jones I M, Wyrobek A J. Candidate protein biodosimeters of human exposure to ionizing radiation. International Journal of Radiation Biology 2006; 82(9)605–639
   PubMed Web of Science ®Google Scholar
• McIntosh J K, Jablons D M, Mule J J, Nordan R P, Rudikoff S, Lotze M T. Rosenberg SA: In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice. Journal of Immunology 1989; 143: 162–167
   PubMed Web of Science ®Google Scholar
• Miller A C, Luo L, Chin W K, Director-Myska A E, Prasanna P GS, Blakely W F. Proto-oncogene expression: A predictive assay for radiation biodosimetry applications. Radiation Protection Dosimetry 2002; 99: 295–302
   PubMed Web of Science ®Google Scholar
• Mouthon M A, Vandamme M, Van der Meeren A, Gourmelon P, Gaugler M-H. Inflammatory response to abdominal irradiation stimulates hemopoiesis. International Journal of Radiation Biology 2001; 77(1)95–103
   PubMedGoogle Scholar
• Neta R, Perlstein R, Vagel S N, Ledney G D, Abrams J. Role of interleukin 6 (IL-6) in protection from lethal irradiation and in endocrine response to IL-1 and tumor necrosis factor. Journal of Experimental Medicine 1992; 175: 689–694
   PubMed Web of Science ®Google Scholar
• Ossetrova N I, Farese A M, MacVittie T J, Manglapus G L, Blakely W F. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements 2007; 42: 1158–1163
   Web of Science ®Google Scholar
• Papathanasiou M A, Kerr N C, Robbins J H, McBridge O W, Aslamo I J, Barrett S F, Hickson I D, Fornace A J. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Molecular and Cellular Biology 1991; 11: 1009–1016
   PubMed Web of Science ®Google Scholar
• Pepys M B, Baltz M L. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Advances in Immunology 1983; 34: 141–212
   PubMed Web of Science ®Google Scholar
• Petrov R. Immunology of acute radiation injury. Joint Publications Research Service, Arlington, VA 1963
   Google Scholar
• Ponnaiya B, Cornforth M N, Ullrich R L. Radiation-induced chromosomal instability in BALB/c and C57BL/6 mice: The difference is as clear as black and white. Radiation Research 1997; 147: 121–125
   PubMed Web of Science ®Google Scholar
• SAS Institute, Inc. SAS/STAT®, Users Guide, Version 6. SAS Institute Inc., Cary, NC 2000
   Google Scholar
• Thomson J F. Radiation protection in mammals. Reinhold Publishing Corp, New York 1962
   Google Scholar
• Tukachinski S E, Moiseeva V P. Cx-reactive protein in radiation injury. Bulletin of Experimental Biology and Medicine 1961; 52: 48–52
   Google Scholar
• Van der Meeren A, Pascale Monti P, Lebaron-Jacobs L, Marquette C, Gourmelon P. Characterization of the acute inflammatory response after irradiation in mice and its regulation by Interleukin 4 (Il4). Radiation Research 2001; 155: 858–865
   PubMedGoogle Scholar
• Wang G G, Clark S C. Multiple action of interleukin-6 within a cytokine network. Immunology Today 1988; 9: 137–139
   PubMedGoogle Scholar
• Waselenko J K, MacVittie T J, Blakely W F, Pesik N, Wiley A L, Dickerson W E, Tsu H, Confer D L, Coleman N, Seed T, Lowry P, Armitage J O, Dainiak N, Strategic National Stockpile Radiation Working Group. Medical management of the acute radiation syndrome: Recommendations of the Strategic National Stockpile Working Group. Annals of Internal Medicine 2004; 140(12)1037–1051
   PubMed Web of Science ®Google Scholar
• Wood H F, Anderle S, Hammond C W, Miller C P. Studies on the Cx-reactive protein. The effect of irradiation on the acute phase protein system. Journal of Experimental Medicine 1960; 111: 601–609
   PubMedGoogle Scholar
• Wyrobek A J, Coleman M A, Nelson D, Krishnan K, Furtado M, Hill F, Marchetti F, Manohar C, Tucker J D. Transcriptome profiling of dose response in human lymphoblastoid cells exposed to ionizing radiation. Environmental and Molecular Mutagenesis 2004; 44: 200–200
   Web of Science ®Google Scholar
• Yin E, Nelson D O, Coleman M A, Paterson L E, Wyrobek A J. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. International Journal of Radiation Biology 2003; 79: 759–775
   PubMed Web of Science ®Google Scholar