Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions

References

• Ahnstrom G, Nygren J, Eriksson S. 2000. The effect of dimethyl sulphoxide on the induction and repair of double-strand breaks in human cells after irradiation with gamma-rays and accelerated ions: rapid or slow repair may depend on accessibility of breaks in chromatin of different compactness. Int J Radiat Biol 76:533–538.
   PubMed Web of Science ®Google Scholar
• Araujo MC, Antunes LM, Takahashi CS. 2001. Protective effect of thiourea, a hydroxyl-radical scavenger, on curcumin-induced chromosomal aberrations in an in vitro mammalian cell system. Teratog Carcinog Mutagen 21:175–180.
   PubMedGoogle Scholar
• Bergeron F, Auvre F, Radicella JP, Ravanat JL. 2010. HO* radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases. Proc Natl Acad Sci USA 107:5528–5533.
   PubMed Web of Science ®Google Scholar
• Buxton GV, Greenstock CL, Helman VP, Ross AB. 1988. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (•OH/O2•-) in aqueous solution. J Phys Chem 17:513–886.
   Web of Science ®Google Scholar
• Cadet J, Delatour T, Douki T, Gasparutto D, Pouget JP, Ravanat JL, Sauvaigo S. 1999. Hydroxyl radicals and DNA base damage. Mutat Res 424:9–21.
   PubMed Web of Science ®Google Scholar
• Cadet J, Douki T, Ravanat JL. 2008. Oxidatively generated damage to the guanine moiety of DNA: mechanistic aspects and formation in cells. Acc Chem Res 41:1075–1083.
   PubMed Web of Science ®Google Scholar
• Cadet J, Douki T, Ravanat JL. 2010. Oxidatively generated base damage to cellular DNA. Free Radic Biol Med 49:9–21.
   PubMed Web of Science ®Google Scholar
• Cadet J, Douki T, Ravanat JL. 2011. Measurement of oxidatively generated base damage in cellular DNA. Mutat Res 711:3–12.
   PubMed Web of Science ®Google Scholar
• Cadet J, Loft S, Olinski R, Evans MD, Bialkowski K, Wagner JR, Dedon PC, Moller P, Greenberg MM, Cooke MS. 2012. Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radic Res 46:367–381.
   PubMed Web of Science ®Google Scholar
• Chiu S, Oleinick NL. 1997. Radioprotection against the formation of DNA double-strand breaks in cellular DNA but not native cellular chromatin by the polyamine spermine. Radiat Res 148:188–192.
   PubMed Web of Science ®Google Scholar
• Dedon PC. 2008. The chemical toxicology of 2-deoxyribose oxidation in DNA. Chem Res Toxicol 21:206–219.
   PubMed Web of Science ®Google Scholar
• Douki T, Bretonniere Y, Cadet J. 2000. Protection against radiation-induced degradation of DNA bases by polyamines. Radiat Res 153:29–35.
   PubMed Web of Science ®Google Scholar
• Douki T, Martini R, Ravanat JL, Turesky RJ, Cadet J. 1997. Measurement of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxo-7,8-dihydroguanine in isolated DNA exposed to gamma radiation in aqueous solution. Carcinogenesis 18:2385–2391.
   PubMed Web of Science ®Google Scholar
• Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, 2nd, Vina J, Davies KJ. 2015. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med 78:233–235.
   PubMed Web of Science ®Google Scholar
• Frelon S, Douki T, Ravanat JL, Pouget JP, Tornabene C, Cadet J. 2000. High-performance liquid chromatography–tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA. Chem Res Toxicol 13:1002–1010.
   PubMed Web of Science ®Google Scholar
• Gharib B, Hanna S, Abdallahi OM, Lepidi H, Gardette B, De Reggi M. 2001. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III 324:719–724.
   PubMed Web of Science ®Google Scholar
• Harper A, Kerr DJ, Gescher A, Chipman JK. 1999. Antioxidant effects of isoflavonoids and lignans, and protection against DNA oxidation. Free Radic Res 31:149–160.
   PubMed Web of Science ®Google Scholar
• Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K. 2015. Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Med Gas Res 5:12.
   PubMed Web of Science ®Google Scholar
• Kraljic I, Trumbore CN. 1965. p-Nitrosodimethylaniline as an OH radical scavenger in radiation chemistry. J Am Chem Soc 87:2547–2550.
   Web of Science ®Google Scholar
• Lango T, Morland T, Brubakk AO. 1996. Diffusion coefficients and solubility coefficients for gases in biological fluids and tissues: a review. Undersea Hyperb Med 23:247–272.
   PubMed Web of Science ®Google Scholar
• Nayvelt I, Hyvonen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsalainen J, Patel R, Keinanen TA, Thomas TJ. 2010. DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage. Biomacromolecules 11:97–105.
   PubMed Web of Science ®Google Scholar
• Newton GL, Aguilera JA, Ward JF, Fahey RC. 1997. Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage. Radiat Res 148:272–284.
   PubMed Web of Science ®Google Scholar
• Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. 2007. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13:688–694.
   PubMed Web of Science ®Google Scholar
• Peebles DD, Soref CM, Copp RR, Thunberg AL, Fahl WE. 2012. ROS-scavenger and radioprotective efficacy of the new PrC-210 aminothiol. Radiat Res 178:57–68.
   PubMed Web of Science ®Google Scholar
• Pogozelski WK, Tullius TD. 1998. Oxidative strand scission of nucleic acids: routes initiated by hydrogen abstraction from the sugar moiety. Chem Rev 98:1089–1108.
   PubMed Web of Science ®Google Scholar
• Pouget JP, Douki T, Richard MJ, Cadet J. 2000. DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay. Chem Res Toxicol 13:541–549.
   PubMed Web of Science ®Google Scholar
• Qian L, Shen J, Chuai Y, Cai J. 2013. Hydrogen as a new class of radioprotective agent. Int J Biol Sci 9:887–894.
   PubMed Web of Science ®Google Scholar
• Rokhlenko Y, Cadet J, Geacintov NE, Shafirovich V. 2014. Mechanistic aspects of hydration of guanine radical cations in DNA. J Am Chem Soc 136:5956–5962.
   PubMed Web of Science ®Google Scholar
• Spotheim-Maurizot M, Garnier F, Kieda C, Sabattier R, Charlier M. 1993. N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons. Radiat Environ Biophys 32:337–343.
   PubMed Web of Science ®Google Scholar
• Stanton J, Taucher-Scholz G, Schneider M, Heilmann J, Kraft G. 1993. Protection of DNA from high LET radiation by two OH radical scavengers, tris (hydroxymethyl) aminomethane and 2-mercaptoethanol. Radiat Environ Biophys 32:21–32.
   PubMed Web of Science ®Google Scholar
• Sy D, Hugot S, Savoye C, Ruiz S, Charlier M, Spotheim-Maurizot M. 1999. Radioprotection of DNA by spermine: a molecular modelling approach. Int J Radiat Biol 75:953–961.
   PubMed Web of Science ®Google Scholar
• Terasaki Y, Ohsawa I, Terasaki M, Takahashi M, Kunugi S, Dedong K, Urushiyama H, Amenomori S, Kaneko-Togashi M, Kuwahara N, Ishikawa A, Kamimura N, Ohta S, Fukuda Y. 2011. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. Am J Physiol Lung Cell Mol Physiol 301:L415–L426.
   PubMed Web of Science ®Google Scholar
• Warters RL, Newton GL, Olive PL, Fahey RC. 1999. Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine. Radiat Res 151:354–362.
   PubMed Web of Science ®Google Scholar
• Watanabe S, Fujita M, Ishihara M, Tachibana S, Yamamoto Y, Kaji T, Kawauchi T, Kanatani Y. 2014. Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats. J Radiat Res 55:1107–1113.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Landauer MR. 2009. History and development of radiation-protective agents. Int J Radiat Biol 85:539–573.
   PubMed Web of Science ®Google Scholar
• Xie Q, Li XX, Zhang P, Li JC, Cheng Y, Feng YL, Huang BS, Zhuo YF, Xu GH. 2014. Hydrogen gas protects against serum and glucose deprivationinduced myocardial injury in H9c2 cells through activation of the NFE2 related factor 2/heme oxygenase 1 signaling pathway. Mol Med Rep 10:1143–1149.
   PubMed Web of Science ®Google Scholar
• Zheng S, Newton GL, Ward JF, Fahey RC. 1992. Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat Res 130:183–193.
   PubMed Web of Science ®Google Scholar