Radiosensitization of ultrasmall GNP–PEG–cRGDfK in ALTS1C1 exposed to therapeutic protons and kilovoltage and megavoltage photons

References

• Albanese A, Chan CW. 2011. Effect of gold nanoparticle aggregation on cell uptake and toxicity. ACS Nano. 5:5478–5489.
   PubMed Web of Science ®Google Scholar
• Al Zaki A, Hui JZ, Higbee E, Tsourkas A. 2015. Biodistribution, clearance, and toxicology of polymeric micelles loaded with 0.9 or 5 nm gold nanoparticles. J Biomed Nanotechnol. 11:1836–1846.
   PubMed Web of Science ®Google Scholar
• Butterworth KT, Coulter JA, Jain S, Forker J, McMahon SJ, Schettino G, Prise KM, Currell FJ, Hirst DG. 2010. Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy. Nanotechnology. 21:295101.
   PubMed Web of Science ®Google Scholar
• Chiang CS, Fu SY, Wang SC, Yu CF, Chen FH, Lin CM, Hong JH. 2012. Irradiation promotes an M2 macrophage phenotype in tumor hypoxia. Front Oncol. 2:89.
   PubMedGoogle Scholar
• Christmann M, Diesler K, Majhen D, Steigerwald C, Berte N, Freund H. 2017. Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair. Oncotarget. 8:27754–27771.
   PubMed Web of Science ®Google Scholar
• Corti A, Curnis F. 2011. Isoaspartate-dependent molecular switches for integrin-ligand recognition. J Cell Sci. 124:515–522.
   PubMed Web of Science ®Google Scholar
• Coulter JA, Jain S, Butterworth KT, Taggart LE, Dickson GR, McMahon SJ, Hyland WB, Muir MF, Trainor C, Hounsell AR, et al. 2012. Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles. Int J Nanomedicine. 7:2673–2685.
   PubMed Web of Science ®Google Scholar
• Danhier F, Le Breton A, Préat V. 2012. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Mol Pharm. 9:2961–2973.
   PubMed Web of Science ®Google Scholar
• Fan CH, Ting CY, Chang YC, Wei KC, Liu HL, Yeh CK. 2015. Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery. Acta Biomater. 15:89–101.
   PubMed Web of Science ®Google Scholar
• Fan C-H, Chang E-L, Ting C-Y, Lin Y-C, Liao E-C, Huang C-Y, Chang Y-C, Chan H-L, Wei K-C, Yeh C-K. 2016. Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery. Biomaterials. 106:46–57.
   PubMed Web of Science ®Google Scholar
• Fertil B, Dertinger H, Courdi A, Malaise EP. 1984. Mean activation dose: a useful concept for intercomparison of human cell survival curves. Radiat Res. 99:73–64.
   PubMed Web of Science ®Google Scholar
• Haume K, Rosa S, Grellet S, Śmiałek MA, Butterworth KT, Solov'yov AV, Prise KM, Golding J, Mason NJ. 2016. Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnol. 7:8.
   PubMedGoogle Scholar
• Hébert EM, Debouttière PJ, Lepage M, Sanche L, Hunting DJ. 2010. Preferential tumour accumulation of gold nanoparticles, visualised by magnetic resonance imaging: radiosensitisation studies in vivo and in vitro. Int J Radiat Biol. 86:692–700.
   PubMed Web of Science ®Google Scholar
• Her S, Jaffray DA, Allen C. 2017. Gold nanoparticles for applications in cancer radiotherapy: mechanisms and recent advancements. Adv Drug Deliv Rev. 109:84–101.
   PubMed Web of Science ®Google Scholar
• Heuskin AC, Gallez B, Feron O, Martinive P, Michiels C, Lucas S. 2017. Metallic nanoparticles irradiated by low-energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery? Med Phys. 44:4299–4312.
   PubMed Web of Science ®Google Scholar
• Jain S, Coulter JA, Hounsell AR, Butterworth KT, McMahon SJ, Hyland WB, Muir MF, Dickson GR, Prise KM, Currell FJ, et al. 2011. Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys. 79:531–539.
   PubMed Web of Science ®Google Scholar
• Jeynes JC, Merchant MJ, Spindler A, Wera AC, Kirkby KJ. 2014. Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies. Phys Med Biol. 59:6431–6443.
   PubMed Web of Science ®Google Scholar
• Kim JK, Seo SJ, Kim KH, Kim TJ, Chung MH, Kim KR, Yang TK. 2010. Therapeutic application of metallic nanoparticles combined with particle-induced X-ray emission effect. Nanotechnology. 21:425102.
   PubMed Web of Science ®Google Scholar
• Kim YH, Jeon J, Hong SH, Rhim WK, Lee YS, Youn H, Chung J-K, Lee MC, Lee DS, Kang KW, Nam J-M. 2011. Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated Iodine-125. Small. 7:2052–2060.
   PubMed Web of Science ®Google Scholar
• Kim SR, Kim EH. 2017. Gold nanoparticles as dose-enhancement agent for kilovoltage X-ray therapy of melanoma. Int J Radiat Biol. 93:517–526.
   PubMed Web of Science ®Google Scholar
• Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Chung J-K, Lee MC, Lee DS, Kang KW, et al. 2015. Nanoparticle mediated tumor vascular disruption: a novel strategy in radiation therapy. Nano Lett. 15:7488–7496.
   PubMed Web of Science ®Google Scholar
• Li P, Shi YW, Li BX, Xu WC, Shi ZL, Zhou C, Fu S. 2015. Photo-thermal effect enhances the efficiency of radiotherapy using Arg-Gly-Asp peptides-conjugated gold nanorods that target αvβ3 in melanoma cancer cells. J Nanobiotechnol. 13:52.
   PubMed Web of Science ®Google Scholar
• Li S, Penninckx S, Karmani L, Heuskin AC, Watillon K, Marega R, Zola J, Corvaglia V, Genard G, Gallez B, et al. 2016. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. Nanotechnology. 27:455101.
   PubMed Web of Science ®Google Scholar
• Lin Y, McMahon SJ, Scarpelli M, Paganetti H, Schuemann J. 2014. Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Phys Med Biol. 59:7675–7689.
   PubMed Web of Science ®Google Scholar
• Lin Y, McMahon SJ, Paganetti H, Schuemann J. 2015. Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy. Phys Med Biol. 60:4149–4168.
   PubMed Web of Science ®Google Scholar
• Liu SK, Coackley C, Krause M, Jalali F, Chan N, Bristow RG. 2008. A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia. Radiother Oncol. 88:258–268.
   PubMed Web of Science ®Google Scholar
• Liu CJ, Wang CH, Chen ST, Chen HH, Leng WH, Chien CC, Wang CL, Kempson IM, Hwu Y, Lai TC. 2010. Enhancement of cell radiation sensitivity by pegylated gold nanoparticles. Phys Med Biol. 55:931–945.
   PubMed Web of Science ®Google Scholar
• Mousavi M, Nedaei HA, Khoei S, Eynali S, Khoshgard K, Robatjazi M, Iraji Rad R. 2017. Enhancement of radiosensitivity of melanoma cells by pegylated gold nanoparticles under irradiation of megavoltage electrons. Int J Radiat Biol. 93:214–221.
   PubMed Web of Science ®Google Scholar
• Park HM. 2005. Comparing group means: the T-test and one-way ANOVA using STATA, SAS, and SPSS. http://stat.smmu.edu.cn/DOWNLOAD/ebook/statistics_course.pdf
   Google Scholar
• Polf JC, Bronk LF, Driessen WH, Arap W, Pasqualini R, Gillin M. 2011. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles. Appl Phys Lett. 98:193702.
   PubMed Web of Science ®Google Scholar
• Poon W, Zhang X, Bekah D, Teodoro JG, Nadeau JL. 2015. Targeting B16 tumors in vivo with peptide-conjugated gold nanoparticles. Nanotechnology. 26:285101.
   PubMed Web of Science ®Google Scholar
• Rosa S, Connolly C, Schettino G, Butterworth KT, Prise KM. 2017. Biological mechanisms of gold nanoparticle radiosensitization. Cancer Nano. 8:2.
   PubMed Web of Science ®Google Scholar
• Saberi A, Shahbazi-Gahrouei D, Abbasian M, Fesharaki M, Baharlouei A, Arab-Bafrani Z. 2017. Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells. Int J Radiat Biol. 93:315–323.
   PubMed Web of Science ®Google Scholar
• Sakagami H, Kishino K, Amano O, Kanda Y, Kunii S, Yokote Y, Oizumi H, Oizumi T. 2009. Cell death induced by nutritional starvation in mouse macrophage-like RAW 264.7 cells. Anticancer Res. 29:343–348.
   PubMed Web of Science ®Google Scholar
• Schrand AM, Schlager JJ, Dai L, Hussain SM. 2010. Preparation of cells for assessing ultrastructural localization of nanoparticles with transmission electron microscopy. Nat Protoc. 5:744–757.
   PubMed Web of Science ®Google Scholar
• Soleymanifard S, Rostami A, Aledavood SA, Matin MM, Sazgarnia A. 2017. Increased radiotoxicity in two cancerous cell lines irradiated by low and high energy photons in the presence of thio-glucose bound gold nanoparticles. Int J Radiat Biol. 93:407–415.
   PubMed Web of Science ®Google Scholar
• Soji T, Murata Y, Ohira A, Nishizono H, Tanaka M, Herbert DC. 1992. Evidence that hepatocytes can phagocytize exogenous substances. Anat Rec. 233:543–554.
   PubMedGoogle Scholar
• Song L, Falzone N, Vallis KA. 2016. EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer. Int J Radiat Biol. 92:716–723.
   PubMed Web of Science ®Google Scholar
• Su N, Dang Y, Liang G, Liu G. 2015. Iodine-125-labeled cRGD-gold nanoparticles as tumor-targeted radiosensitizer and imaging agent. Nanoscale Res Lett. 10:160.
   PubMed Web of Science ®Google Scholar
• Taggart LE, McMahon SJ, Butterworth KT, Currell FJ, Schettino G, Prise KM. 2016. Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation. Nanotechnology. 27:215101.
   PubMed Web of Science ®Google Scholar
• Wang SC, Hong JH, Hsueh C, Chiang CS. 2012. Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Lab Invest. 92:151–162.
   PubMed Web of Science ®Google Scholar
• Wang SC, Yu CF, Hong JH, Tsai CS, Chiang CS. 2013. Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS One. 8:e69182.
   PubMed Web of Science ®Google Scholar
• Wu JC, Merlino G, Fausto N. 1994. Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha. Proc Natl Acad Sci USA. 91:674–678.
   PubMed Web of Science ®Google Scholar
• Zhang XD, Luo Z, Chen J, Song S, Yuan X, Shen X, Wang H, Sun Y, Gao K, Zhang L, et al. 2015. Ultrasmall glutathione-protected gold nanoclusters as next generation radiotherapy sensitizers with high tumor uptake and high renal clearance. Sci Rep. 5:8669.
   PubMed Web of Science ®Google Scholar