Saving normal tissues – a goal for the ages

References

• Abd El-Azime AS, Hussein EM, Ashry OM. 2014. Synergestic effect of aqueous purslane (Portulaca oleracea L.) extract and fish oil on radiation-induced damage in rats. Int J Radiat Biol. 90(12):1184–1190.
   PubMed Web of Science ®Google Scholar
• Abdel-Magied N, Ahmed AG, Abo Zid N. 2018. Possible ameliorative effect of aqueous extract of date (Phoenix dactylifera) pits in rats exposed to gamma radiation. Int J Radiat Biol. 94(9):815–824.
   PubMed Web of Science ®Google Scholar
• Advisory Committee on Human Radiation Experiments. 1996. Report of the advisory committee on human radiation experiments. Research ethics and the medical profession. JAMA. 276:403–409.
   PubMed Web of Science ®Google Scholar
• An DD, Villalobos JA, Morales-Rivera JA, Rosen CJ, Bjornstad KA, Gauny SS, Choi TA, Sturzbecher-Hoehne M, Abergel RJ. 2014. (238)Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice. Int J Radiat Biol. 90(11):1055–1061.
   PubMed Web of Science ®Google Scholar
• Aricigil M, Dundar MA, Yucel A, Eryilmaz MA, Aktan M, Alan MA, Findik S, Kilinc I. 2017. Melatonin prevents possible radiotherapy-induced thyroid injury. Int J Radiat Biol. 93:1350–1356.
   PubMed Web of Science ®Google Scholar
• Ashry OM, Hussein EM, Abd El-Azime AS. 2017. Restorative role of persimmon leaf (Diospyros kaki) to gamma irradiation-induced oxidative stress and tissue injury in rats. Int J Radiat Biol. 93(3):324–329.
   PubMed Web of Science ®Google Scholar
• Ashwood-Smith MJ. 1961. Inability of dimethyl sulphoxide to protect mouse testis against the effect of X-radiation. Int J Rad Biol Rel Stud Phys Chem Med. 3:101–103.
   Web of Science ®Google Scholar
• Ashwood-Smith MJ. 1962. Radioprotective effect of combinations of AET or cysteamine with dimethyl sulphoxide. Int J Radiat Biol Rel Stud Phys Chem Med. 5(2):201–202.
   PubMed Web of Science ®Google Scholar
• Ashwood-Smith MJ, Smith AD. 1959. Radioprotective action of S-alkyl-iso-thiuronium salts. Int J Radiat Biol Rel Stud Phys Chem Med. 1(2):196–198.
   Web of Science ®Google Scholar
• Ayene SI, Kale RK, Srivastava PN. 1988. Radioprotective effect of 2-mercaptopropionyl glycine on radiation-induced lipid peroxidation and enzyme release in erythrocytes. Int J Radiat Biol. 53(4):629–639.
   Web of Science ®Google Scholar
• Ayene SI, Srivastava PN. 1989. Effect of WR-2721 on radiation-induced lipid peroxidation and enzyme release in erythrocytes and microsomes. Int J Radiat Biol. 56(3):265–275.
   PubMed Web of Science ®Google Scholar
• Bacq ZM, Herve A. 1952. A new protection against x-rays. Schweiz Med Wochenschr. 82:1018–1020.
   PubMedGoogle Scholar
• Barendsen GW. 1982. Dose fractionation, dose rate and iso-effect relationships for normal tissue responses. Int J Radiat Oncol Biol Phys. 8:1981–1997.
   PubMed Web of Science ®Google Scholar
• Baskar R, Lee KA, Yeo R, Yeoh KW. 2012. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 9:193–199.
   PubMed Web of Science ®Google Scholar
• Baulch JE. 2018. Radiation-induced genomic instability, epigenetic mechanisms and the mitochondria: a dysfunctional ménage a trois? Int J Radiat Biol. 1–15. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Beach TA, Johnston CJ, Groves AM, Williams JP, Finkelstein JN. 2017. Radiation induced pulmonary fibrosis as a model of progressive fibrosis: contributions of DNA damage, inflammatory response and cellular senescence genes. Exp Lung Res. 43:134–149.
   PubMed Web of Science ®Google Scholar
• Bentzen SM. 2006. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer. 6:702–713.
   PubMed Web of Science ®Google Scholar
• Bentzen SM, Parliament M, Deasy JO, Dicker A, Curran WJ, Williams JP, Rosenstein BS. 2010. Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects. Int J Radiat Oncol Biol Phys. 76:S145–S150.
   PubMed Web of Science ®Google Scholar
• Bespalov VG, Alexandrov VA, Semenov AL, Kovan'Ko EG, Ivanov SD. 2014. Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats. Int J Radiat Biol. 90(12):1191–1200.
   PubMed Web of Science ®Google Scholar
• Bespalov VG, Alexandrov VA, Semenov AL, Kovan'ko EG, Ivanov SD, Vysochina GI, Kostikova VA, Baranenko DA. 2017. The inhibitory effect of meadowsweet (Filipendula ulmaria) on radiation-induced carcinogenesis in rats. Int J Radiat Biol. 93(4):394–401.
   PubMed Web of Science ®Google Scholar
• Blyth BJ. 2018. The paradox of adaptive responses and iso-effect per fraction. Int J Radiat Biol. 94:737–742.
   PubMed Web of Science ®Google Scholar
• Bose A. 1959. Modification of 59Fe uptake in the circulating blood of lethally irradiated rats protected with cyanide. Int J Radiat Biol Rel Stud Phys Chem Med. 1(4):383–386.
   PubMed Web of Science ®Google Scholar
• Brenner DJ, Chao NJ, Greenberger JS, Guha C, McBride WH, Swartz HM, Williams JP. 2015. Are we ready for a radiological terrorist attack yet? Report from the centers for medical countermeasures against radiation network. Int J Radiat Oncol Biol Phys. 92:504–505.
   PubMed Web of Science ®Google Scholar
• Bridges BA, Koch R. 1961. Radiation-protection by some sulphydryl derivatives of pyroxidine and a new BAL preparation. Int J Radiat Biol Rel Stud Phys Chem Med. 3(1):49–58.
   Web of Science ®Google Scholar
• Bright S, Kadhim M. 2018. The future impacts of non-targeted effects. Int J Radiat Biol. 94:727–736.
   PubMed Web of Science ®Google Scholar
• Brook I, Walker RI, MacVittie TJ. 1988. Effect of antimicrobial therapy on bowel flora and bacterial infection in irradiated mice. Int J Rad Biol Rel Stud Phys Chem Med. 53:709–716.
   Google Scholar
• Brooks AL. 1999. Biomarkers of exposure, sensitivity and disease. Int J Radiat Biol. 75:1481–1503.
   PubMed Web of Science ®Google Scholar
• Bruenger FW, Taylor DM, Taylor GN, Lloyd RD. 1991. Effectiveness of DTPA treatments following the injection of particulate plutonium. Int J Radiat Biol. 60:803–818.
   PubMed Web of Science ®Google Scholar
• Burtt JJ, Thompson PA, Lafrenie RM. 2016. Non-targeted effects and radiation-induced carcinogenesis: a review. J Radiol Prot. 36:R23–R35.
   PubMed Web of Science ®Google Scholar
• Bykov VN, Drachev IS, Kraev SY, Maydin MA, Gubareva EA, Pigarev SE, Anisimov VN, Baldueva IA, Fedoros EI, Panchenko AV. 2018. Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation. Int J Radiat Biol. 94(2):114–123.
   PubMed Web of Science ®Google Scholar
• Chatterjee R, Bose A, De P. 1959. Evaluation of radio-protective efficacy of cysteamine (with rat-liver-cell glycogen as a reference system). Int J Radiat Biol Rel Stud Phys Chem Med. 1(4):420–424.
   PubMed Web of Science ®Google Scholar
• Cheng L, Lisowska H, Sollazzo A, Wegierek-Ciuk A, Stepień K, Kuszewski T, Lankoff A, Haghdoost S, Wojcik A. 2015. Modulation of radiation-induced cytogenetic damage in human peripheral blood lymphocytes by hypothermia. Mutat Res Genet Toxicol Environ Mutagen. 793:96–100.
   PubMed Web of Science ®Google Scholar
• Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, et al. 2014. Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells. Int J Radiat Biol. 90:841–852.
   PubMed Web of Science ®Google Scholar
• Cohen J, Vo NTK, Seymour CB, Mothersill CE. 2019. Parallel comparison of pre-conditioning and post-conditioning effects in human cancers and keratinocytes upon acute gamma irradiation. Int J Radiat Biol. 95(2):170–178.
   Web of Science ®Google Scholar
• Coleman CN, Parker GW. 2009. Radiation terrorism: what society needs from the radiobiology-radiation protection and radiation oncology communities. J Radiol Prot. 29:A159–A169.
   PubMed Web of Science ®Google Scholar
• Dacquisto MP, Rothe WE, Blackburn EW. 1961. Mechanism of the protective action of 2-mercaptoethylguanidine (MEG) against whole-body radiation in mice. Int J Radiat Biol Rel Stud Phys Chem Med. 4(1):33–42.
   PubMedGoogle Scholar
• Das U, Biswas S, Sengupta A, Manna K, Chakraborty A, Dey S. 2016. Ferulic acid (FA) abrogates ionizing radiation-induced oxidative damage in murine spleen. Int J Radiat Biol. 92(12):806–818.
   PubMed Web of Science ®Google Scholar
• Davis AK, Cranmore D, Alpen EL. 1958. Alteration of beta-radiation lesions of the skin by cysteine nitrite, hypoxia, spleen homogenate, and bone marrow homogenate. Radiat Res. 9:222–228.
   PubMed Web of Science ®Google Scholar
• Deanovic Z, Supek Z, Bulat M. 1963. Effect of chemoprotection by cystamine on urinary excretion of 5-hydroxyindoleacetic acid in X-irradiated rats. Int J Radiat Biol Rel Stud Phys Chem Med. 7(1):109–111.
   PubMed Web of Science ®Google Scholar
• DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, et al. 2015. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 91:510–518.
   PubMed Web of Science ®Google Scholar
• Dewey WL. 1963. The effect of protectors on Serratia marcescens during anaerobic X-irradiation. Int J Radiat Biol Rel Stud Phys Chem Med. 7(2):151–154.
   PubMed Web of Science ®Google Scholar
• El-Desouky W, Hanafi A, Abbas MM. 2017. Radioprotective effect of green tea and grape seed extracts mixture on gamma irradiation induced immune suppression in male albino rats. Int J Radiat Biol. 93(4):433–439.
   PubMed Web of Science ®Google Scholar
• El-Ghazaly MA, El-Hazek RM, Khayyal MT. 2015. Protective effect of the herbal preparation, STW 5, against intestinal damage induced by gamma radiation in rats. Int J Radiat Biol. 91(2):150–156.
   PubMed Web of Science ®Google Scholar
• El-Missiry MA, Othman AI, El-Sawy MR, Lebede MF. 2018. Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus. Int J Radiat Biol. 94(9):798–808.
   PubMed Web of Science ®Google Scholar
• El-Sheikh MM, El-Hazek RM, El-Khatib AS, El-Ghazaly MA. 2018. Anti-apoptotic effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, against multiple organ damage induced by gamma irradiation in rats. Int J Radiat Biol. 94(1):45–53.
   PubMed Web of Science ®Google Scholar
• Elliott TB, Bolduc DL, Ledney GD, Kiang JG, Fatanmi OO, Wise SY, Romaine PL, Newman VL, Singh VK. 2015. Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice. Int J Radiat Biol. 91(9):690–702.
   PubMed Web of Science ®Google Scholar
• Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. 1991. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 21:109–122.
   PubMed Web of Science ®Google Scholar
• Fallowfield TL. 1962. The influence of hypothermia involving minimal hypoxia on the radiosensitivity of leucocytes in the rat. Int J Radiat Biol Relat Stud Phys Chem Med. 4:457–464.
   PubMed Web of Science ®Google Scholar
• Fatome M, Courteille F, Laval JD, Roman V. 1987. Radioprotective activity of ethylcellulose microspheres containing WR 2721, after oral administration. Int J Radiat Biol Rel Stud Phys Chem Med. 52(1):21–29.
   PubMed Web of Science ®Google Scholar
• Fazelipour S, Kiaei SB, Tootian Z, Haeri SA, Zehtabvar O, Sadeghinezhad J. 2015. Cimetidine administration decreases radiogenic damage on the thyroid gland in mice. Int J Radiat Biol. 91(3):218–223.
   PubMed Web of Science ®Google Scholar
• Fish BL, Gao F, Narayanan J, Bergom C, Jacobs ER, Cohen EP, Moulder JE, Orschell CM, Medhora M. 2016. Combined hydration and antibiotics with Lisinopril to mitigate acute and delayed high-dose radiation injuries to multiple organs. Health Phys. 111:410–419.
   PubMed Web of Science ®Google Scholar
• Flood AB, Williams BB, Schreiber W, Du G, Wood VA, Kmiec MM, Petryakov SV, Demidenko E, Swartz HM. 2016. Advances in in vivo EPR tooth BIOdosimetry: meeting the targets for initial triage following a large-scale radiation event. Radiat Prot Dosimetry. 172:72–80.
   PubMed Web of Science ®Google Scholar
• Folley JH, Borges W, Yamawaki T. 1952. Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan. Am J Med. 13:311–321.
   PubMed Web of Science ®Google Scholar
• Fowler JF. 2006. Development of radiobiology for oncology-a personal view. Phys Med Biol. 51:R263–R286.
   PubMed Web of Science ®Google Scholar
• Freitas RB, Gonzalez P, Martins NM, Andrade ER, Cesteros Morante MJ, Conles Picos I, Costilla Garcia S, Bauermann LF, Barrio JP. 2017. Ameliorative effect of black grape juice on systemic alterations and mandibular osteoradionecrosis induced by whole brain irradiation in rats. Int J Radiat Biol. 93(2):204–213.
   PubMed Web of Science ®Google Scholar
• Fukuda K, Uehara Y, Nakata E, Inoue M, Shimazu K, Yoshida T, Kanda H, Nanjo H, Hosoi Y, Yamakoshi H, et al. 2016. A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa. Int J Radiat Biol. 92:388–394.
   PubMed Web of Science ®Google Scholar
• Gaddis JL. 2006. The cold war: a new history. New York (NY): Penguin Books.
   Google Scholar
• Galli G. 1959. The therapeutic possibilities of various chelating substances in radiation sickness. Minerv Fisioter Radiobiol. 4:322–327.
   PubMedGoogle Scholar
• Gawade PL, Hudson MM, Kaste SC, Neglia JP, Wasilewski-Masker K, Constine LS, Robison LL, Ness KK. 2014. A systematic review of selected musculoskeletal late effects in survivors of childhood cancer. Curr Pediatr Rev. 10:249–262.
   PubMedGoogle Scholar
• Gifford G, Sim J, Horne A, Ma D. 2014. Health status, late effects and long-term survivorship of allogeneic bone marrow transplantation: a retrospective study. Intern Med J. 44:139–147.
   PubMed Web of Science ®Google Scholar
• Grant GA, Vos O. 1962. Chemical protection of rat thymocytes irradiated in vitro. Int J Radiat Biol Relat Stud Phys Chem Med. 5:413–425.
   PubMed Web of Science ®Google Scholar
• Guilmette RA, Muggenburg BA. 1988. Reducing the radiation dose from inhaled americium-241 using continuously administered DTPA therapy. Int J Radiat Biol Rel Stud Phys Chem Med. 53(2):261–271.
   PubMedGoogle Scholar
• Hafer N, Cassatt D, Dicarlo A, Ramakrishnan N, Kaminski J, Norman MK, Maidment B, Hatchett R. 2010. NIAID/NIH radiation/nuclear medical countermeasures product research and development program. Health Phys. 98:903–905.
   PubMed Web of Science ®Google Scholar
• Hanson WR, Grdina DJ. 1987. Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2. Int J Radiat Biol Rel Stud Phys Chem Med. 52(1):67–76.
   PubMed Web of Science ®Google Scholar
• Harada T, Ishida MI. 1960. Neoplasms among A-bomb survivors in Hiroshima: first report of the research committee on tumor statistics, Hiroshima city medical association, Hiroshima, Japan. J Natl Cancer Inst. 25:1253–1264.
   PubMedGoogle Scholar
• Hendry JH. 1979. Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses. Int J Radiat Oncol Biol Phys. 5:971–976.
   PubMed Web of Science ®Google Scholar
• Herodin F, Laval JD, Fatome M, Fauve RM. 1987. Radioprotective effect of an acute non-specific inflammation in mice. Int J Radiat Biol Rel Stud Phys Chem Med. 51(3):549–559.
   PubMed Web of Science ®Google Scholar
• Himburg HA, Sasine J, Yan X, Kan J, Dressman H, Chute JP. 2016. A molecular profile of the endothelial cell response to ionizing radiation. Radiat Res. 186:141–152.
   PubMed Web of Science ®Google Scholar
• Hirama T, Tanosaki S, Kandatsu S, Kuroiwa N, Kamada T, Tsuji H, Yamada S, Katoh H, Yamamoto N, Tsujii H, et al. 2003. Initial medical management of patients severely irradiated in the Tokai-mura criticality accident. Br J Radiol. 76:246–253.
   PubMed Web of Science ®Google Scholar
• Homer MJ, Raulli R, DiCarlo-Cohen AL, Esker J, Hrdina C, Maidment BW, Moyer B, Rios C, Macchiarini F, Prasanna PG, et al. 2016. United States department of health and human services biodosimetry and radiological/nuclear medical countermeasure programs. Radiat Prot Dosimetry. 171:85–98.
   PubMed Web of Science ®Google Scholar
• Hoving S, Seemann I, Visser NL, te Poele JA, Stewart FA. 2013. Thalidomide is not able to inhibit radiation-induced heart disease. Int J Radiat Biol. 89(9):685–691.
   PubMed Web of Science ®Google Scholar
• Huang EY, Peng CT, Wang CC. 2018. Effects of radiation response modifiers given after lethal whole-abdominal irradiation. Int J Radiat Biol. 94:289–294.
   PubMed Web of Science ®Google Scholar
• Huckle JE, Sadgrove MP, Pacyniak E, Leed MG, Weber WM, Doyle-Eisele M, Guilmette RA, Agha BJ, Susick RL, Mumper RJ et al. 2015. Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: assessment of safety and efficacy in an inhalation-contamination model. Int J Radiat Biol. 91(7):568–575.
   PubMed Web of Science ®Google Scholar
• Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME. 2001. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A. 98:1294–1299.
   PubMed Web of Science ®Google Scholar
• Ioannides KG, Mantzios AS, Pappas CP. 1991. Influence of Prussian blue in reducing transfer of radiocesium into ovine milk. Health Phys. 60:261–264.
   PubMed Web of Science ®Google Scholar
• Iversen ES, McCarthy JM, Bell Burdett K, Lipton G, Phillips G, Dressman H, Ross J, Chao N. 2018. Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans. Int J Radiat Biol. 1–10. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Jacobs AR, Guyon T, Headley V, Nair M, Ricketts W, Gray G, Wong JYC, Chao N, Terbrueggen R. 2018. Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident. Int J Radiat Biol. 1–9. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Kalinich JF, Catravas GN, Snyder SL. 1991. Radioprotective properties of DNA methylation-disrupting agents. Int J Radiat Biol. 59:1217–1226.
   PubMed Web of Science ®Google Scholar
• Karami M, Asri-Rezaei S, Dormanesh B, Nazarizadeh A. 2018. Comparative study of radioprotective effects of selenium nanoparticles and sodium selenite in irradiation-induced nephropathy of mice model. Int J Radiat Biol. 94(1):17–27.
   PubMed Web of Science ®Google Scholar
• Kareva I, Abou-Slaybi A, Dodd O, Dashevsky O, Klement GL. 2016. Normal wound healing and tumor angiogenesis as a game of competitive inhibition. PLoS One. 11:e0166655.
   PubMed Web of Science ®Google Scholar
• Khedr MH, Shafaa MW, Abdel-Ghaffar A, Saleh A. 2018. Radioprotective efficacy of Ginkgo biloba and Angelica archangelica extract against technetium-99m-sestamibi induced oxidative stress and lens injury in rats. Int J Radiat Biol. 94(1):37–44.
   PubMed Web of Science ®Google Scholar
• Kostial K, Kargacin B, Landeka M. 1987. Oral Zn-DTPA therapy for reducing 141Ce retention in suckling rats. Int J Radiat Biol Rel Stud Phys Chem Med. 52(4):501–504.
   PubMed Web of Science ®Google Scholar
• Kurishita A, Katoh H, Uehara Y, Uchida A, Mizutani Y, Ono T, Hirose S, Okada S. 1991. Post-irradiation treatment with OK432 can prevent radiation-induced bone marrow death. Int J Radiat Biol. 59(3):711–716.
   PubMed Web of Science ®Google Scholar
• Lafargue A, Degorre C, Corre I, Alves-Guerra MC, Gaugler MH, Vallette F, Pecqueur C, Paris F. 2017. Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. Free Radic Biol Med. 108:750–759.
   PubMed Web of Science ®Google Scholar
• Laiakis EC, Strawn SJ, Brenner DJ, Fornace AJ. Jr. 2016. Assessment of saliva as a potential biofluid for biodosimetry: a pilot metabolomics study in mice. Radiat Res. 186:92–97.
   PubMed Web of Science ®Google Scholar
• Langendorff H, Melching H-J, Ladner H-A. 1959. 5-Hydroxytryptamine as a radiation protective substance in animals. Int J Radiat Biol Rel Stud Phys Chem Med. 1(1):24–27.
   Google Scholar
• Larsson B, Stenson S. 1965. Reduction of radiation damage to the intestinal mucous membrane by local hypoxia. Nature. 205:364–365.
   PubMed Web of Science ®Google Scholar
• Lee Y, Pujol Canadell M, Shuryak I, Perrier JR, Taveras M, Patel P, Koller A, Smilenov LB, Brenner DJ, Chen EI, et al. 2018. Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model. Sci Rep. 8:13557.
   PubMed Web of Science ®Google Scholar
• Li FS, Weng JK. 2017. Demystifying traditional herbal medicine with modern approach. Nat Plants. 3:17109.
   PubMed Web of Science ®Google Scholar
• Li Q, Sun H, Xiao F, Wang X, Yang Y, Liu Y, Zhang Q, Wu C, Wang H, Wang LS. 2014. Protection against radiation-induced hematopoietic damage in bone marrow by hepatocyte growth factor gene transfer. Int J Radiat Biol. 90(1):36–44.
   PubMed Web of Science ®Google Scholar
• Littlefield LG, Joiner EE, Colyer SP, Sayer AM, Frome EL. 1988. Modulation of radiation-induced chromosome aberrations by DMSO, an OH radical scavenger. 1: Dose-response studies in human lymphocytes exposed to 220 kV X-rays. Int J Radiat Biol Rel Stud Phys Chem Med. 53(6):875–890.
   PubMedGoogle Scholar
• Liu C, Liu J, Hao Y, Gu Y, Yang Z, Li H, Li R. 2017. 6,7,3',4'-Tetrahydroxyisoflavone improves the survival of whole-body-irradiated mice via restoration of hematopoietic function. Int J Radiat Biol. 93(8):793–802.
   PubMed Web of Science ®Google Scholar
• Mabro M, Faivre S, Raymond E. 1999. A risk-benefit assessment of amifostine in cytoprotection. Drug Saf. 21:367–387.
   PubMed Web of Science ®Google Scholar
• Macia IGM. 2017. Radiobiology of stereotactic body radiation therapy (SBRT). Rep Pract Oncol Radiother. 22:86–95.
   PubMedGoogle Scholar
• MacVittie TJ, Monroy RL, Patchen ML, Souza LM. 1990. Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation. Int J Radiat Biol. 57(4):723–736.
   PubMed Web of Science ®Google Scholar
• Maisin JR, Novelli GD, Doherty DG, Congdon CC. 1960. Chemical protection of the alimentary tract of whole-body X-irradiated mice. Int J Radiat Biol Rel Stud Phys Chem Med. 2(3):281–293.
   PubMed Web of Science ®Google Scholar
• Maqsood M, Ashikawa JK. 1962. Post-irradiation protection and recovery. I. Effects of lipids on haematopoietic organs of X-irradiated male mice. Int J Radiat Biol Rel Stud Phys Chem Med. 4(5):521–531.
   PubMed Web of Science ®Google Scholar
• Marini M, Zunica G, Tamba M, Cossarizza A, Monti D, Franceschi C. 1990. Recovery of human lymphocytes damaged with gamma-radiation or enzymatically produced oxygen radicals: different effects of poly(ADP-ribosyl)polymerase inhibitors. Int J Radiat Biol. 58(2):279–291.
   PubMed Web of Science ®Google Scholar
• Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Hill RP. 2013. Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats. Radiat Res. 179:125–134.
   PubMed Web of Science ®Google Scholar
• Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Medhora M, Hill RP. 2014. Targeting the Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage. Int J Radiat Oncol Biol Phys. 89:722–728.
   PubMed Web of Science ®Google Scholar
• Malerba F, Orsenigo L. 2015. The evolution of the pharmaceutical industry. Business Hist. 57:664–687.
   Web of Science ®Google Scholar
• Mandl AM. 1959. The effect of cysteamine on the survival of spermatagonia after X-irradiation. Int J Rad Biol Rel Stud Phys Chem Med. 1:131–142.
   Web of Science ®Google Scholar
• Marigold JC, Hume SP. 1982. Effect of prior hyperthermia on subsequent thermal enhancement of radiation damage in mouse intestine. Int J Rad Biol Rel Stud Phys Chem Med. 42:509–516.
   Google Scholar
• McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, Dougherty GJ, Iwamoto KS, Pervan M, Liao YP. 2004. A sense of danger from radiation. Radiat Res. 162:1–19.
   PubMed Web of Science ®Google Scholar
• McBride WH, Mason KA, Peters LJ, Thames HD. 2015. Dr. H. Rodney Withers (1932–2015). Int J Radiat Biol. 91:459–461.
   PubMed Web of Science ®Google Scholar
• McCally M, Cassel C, Kimball DG. 1994. Government-sponsored radiation research on humans 1945–1975. Med Global Surv. 1:4–16.
   PubMedGoogle Scholar
• McDowell LJ, Rock K, Xu W, Chan B, Waldron J, Lu L, Ezzat S, Pothier D, Bernstein LJ, So N, et al. 2018. Long-term late toxicity, quality of life, and emotional distress in patients with nasopharyngeal Carcinoma treated with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 102:340–352.
   PubMed Web of Science ®Google Scholar
• Medhora M, Gao F, Wu Q, Molthen RC, Jacobs ER, Moulder JE, Fish BL. 2014. Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs. Radiat Res. 182:545–555.
   PubMed Web of Science ®Google Scholar
• Miller AC, Rivas R, McMahon R, Miller K, Tesoro L, Villa V, Yanushkevich D, Lison P. 2017. Radiation protection and mitigation potential of phenylbutyrate: delivered via oral administration. Int J Radiat Biol. 93:907–919.
   PubMed Web of Science ®Google Scholar
• Minakawa Y, Atsumi Y, Shinohara A, Murakami Y, Yoshioka K. 2016. Gamma-irradiated quiescent cells repair directly induced double-strand breaks but accumulate persistent double-strand breaks during subsequent DNA replication. Genes Cells. 21:789–797.
   PubMed Web of Science ®Google Scholar
• Mishra K, Alsbeih G. 2017. Appraisal of biochemical classes of radioprotectors: evidence, current status and guidelines for future development. 3 Biotech. 7:292.
   PubMedGoogle Scholar
• Mohamed NE, Ashour SE. 2018. Role of ethanolic extract of Morus alba leaves on some biochemical and hematological alterations in irradiated male rats. Int J Radiat Biol. 94(4):374–384.
   PubMed Web of Science ®Google Scholar
• Moulder JE. 2003. Pharmacological intervention to prevent or ameliorate chronic radiation injuries. Semin Radiat Oncol. 13:73–84.
   PubMed Web of Science ®Google Scholar
• Moulder JE, Cohen EP, Fish BL. 2014. Mitigation of experimental radiation nephropathy by renin-equivalent doses of angiotensin converting enzyme inhibitors. Int J Radiat Biol. 90:762–768.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Chakraborty A. 2018. Radiation-induced bystander phenomenon: insight and implications in radiotherapy. Int J Rad Biol. 1–48. [Epub ahead of print].
   Web of Science ®Google Scholar
• Murray D, Altschuler EM, Kerr MS, Vanankeren SC, Meyn RE, Milas L. 1988. Radioprotection of cultured Chinese hamster ovary cells by WR-255591. Int J Radiat Biol. 54(2):269–283.
   PubMed Web of Science ®Google Scholar
• Murray D, Prager A, Vanankeren SC, Altschuler EM, Kerr MS, Terry NH, Milas L. 1990. Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation. Int J Radiat Biol. 58(1):71–91.
   PubMed Web of Science ®Google Scholar
• Najafi M, Motevaseli E, Shirazi A, Geraily G, Rezaeyan A, Norouzi F, Rezapoor S, Abdollahi H. 2018. Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications. Int J Radiat Biol. 94:335–356.
   PubMed Web of Science ®Google Scholar
• National Council on Radiation Protection and Measurement: NCRP Statement No. 12. 2015. Where are the radiation professionals (WARP)? Bethesda (MD).
   Google Scholar
• Nguyen MH, Pham ND, Dong B, Nguyen TH, Bui CB, Hadinoto K. 2017. Radioprotective activity of curcumin-encapsulated liposomes against genotoxicity caused by Gamma Cobalt-60 irradiation in human blood cells. Int J Radiat Biol. 93(11):1267–1273.
   PubMed Web of Science ®Google Scholar
• Norman A, McBride WH, Bennett LR, Santos Mello R, Iwamoto K, Hidmi H. 1988. Postirradiation protection of chromosomes by linoleate. Int J Radiat Biol. 54:521–524.
   PubMed Web of Science ®Google Scholar
• Norwood WD. 1962. Therapeutic removal of plutonium in humans. Health Phys. 8:747–750.
   PubMedGoogle Scholar
• Oliai C, Yang LX. 2014. Radioprotectants to reduce the risk of radiation-induced carcinogenesis. Int J Radiat Biol. 90:203–213.
   PubMed Web of Science ®Google Scholar
• Patt HM, Tyree EB, Straube RL, Smith DE. 1949. Cysteine protection against X irradiation. Science. 110:213–214.
   PubMed Web of Science ®Google Scholar
• Pejchal J, Šinkorová Z, Tichý A, Kmochová A, Ďurišová K, Kubelková K, Pohanka M, Bureš J, Tachecí I, Kuča K, et al. 2015. Attenuation of radiation-induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice. Int J Radiat Biol. 91:703–714.
   PubMed Web of Science ®Google Scholar
• Pihl A, Eldjarn L. 1958. Pharmacological aspects of ionizing radiation and of chemical protection in mammals. Pharmacol Rev. 10:437–474.
   PubMed Web of Science ®Google Scholar
• Pinho C, Timotin E, Wong R, Sur RK, Hayward JE, Farrell TJ, Seymour C, Mothersill C. 2015. Assessing patient characteristics and radiation-induced non-targeted effects in vivo for high dose-rate (HDR) brachytherapy. Int J Radiat Biol. 91:786–794.
   PubMed Web of Science ®Google Scholar
• Prasad KN, Kollmorgen GM, Kent TH, Osborne JW. 1963. Protective effect of beta-mercaptoethylamine and mesenteric vessel clamping on intestine-irradiated rats. Int J Radiat Biol Relat Stud Phys Chem Med. 6:257–269.
   PubMed Web of Science ®Google Scholar
• Prasad KN, Osborne JW. 1963. Influence of beta-mercaptoethylamine on mucosal uptake of 59fe by intestine-irradiated rat. Int J Radiat Biol Relat Stud Phys Chem Med. 7:245–253.
   PubMed Web of Science ®Google Scholar
• Prasanna PG, Narayanan D, Hallett K, Bernhard EJ, Ahmed MM, Evans G, Vikram B, Weingarten M, Coleman CN. 2015. Radioprotectors and radiomitigators for improving radiation therapy: the Small Business Innovation Research (SBIR) gateway for accelerating clinical translation. Radiat Res. 184:235–248.
   PubMed Web of Science ®Google Scholar
• Praslicka M, Hill M, Novak L. 1962. Protective action of 2,4-dinitrophenol against X-radiation injury. Radioprotective effect of 2,4-dinitrophenol. Int J Radiat Biol Relat Stud Phys Chem Med. 4:567–579.
   PubMed Web of Science ®Google Scholar
• Price PW, DiCarlo AL. 2018. Challenges and benefits of repurposing licensed/approved/cleared products for a radiation indication. Radiat Res.
   Web of Science ®Google Scholar
• Rabender C, Mezzaroma E, Mauro AG, Mullangi R, Abbate A, Anscher M, Hart B, Mikkelsen R. 2016. IPW-5371 proves effective as a radiation countermeasure by mitigating radiation-induced late effects. Radiat Res. 186:478–488.
   PubMed Web of Science ®Google Scholar
• Rahbeeni F, Hendrikse AS, Smuts CM, Gelderblom WC, Abel S, Blekkenhorst GH. 2000. The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue. Int J Radiat Biol. 76:871–877.
   PubMed Web of Science ®Google Scholar
• Ray-Chaudhuri SP, Chaudhuri J, Chatterjee S. 1962. Cysteamine protection of grasshopper chromosomes from X-ray induced aberrations under aerobic and anaerobic conditions. Int J Radiat Biol Rel Stud Phys Chem Med. 5(6):591–595.
   PubMed Web of Science ®Google Scholar
• Ren J, Hao Y, Gao R, Zhang Y, Ran Y, Liu J, Dai X, Xiong W, Su Y, Li R. 2018. Effect of a novel polyethylene glycol compound on lung lavage in dogs after the inhalation of depleted uranium dust. Int J Radiat Biol. 94(5):462–471.
   PubMed Web of Science ®Google Scholar
• Repin M, Pampou S, Karan C, Brenner DJ, Garty G. 2017. RABiT-II: implementation of a high-throughput micronucleus biodosimetry assay on commercial biotech robotic systems. Radiat Res. 187:492–498.
   PubMed Web of Science ®Google Scholar
• Rios CI, Cassatt DR, Dicarlo AL, Macchiarini F, Ramakrishnan N, Norman MK, Maidment BW. 2014. Building the strategic national stockpile through the NIAID radiation nuclear countermeasures program. Drug Dev Res. 75:23–28.
   PubMed Web of Science ®Google Scholar
• Rixon RH, Whitaker JN. 1961. The radioprotective action of parathyroid extract. Int J Radiat Biol Rel Stud Phys Chem Med. 3(4):361–367.
   PubMed Web of Science ®Google Scholar
• Rixon RH, Whitfield JF. 1961. The effect of ethylenediaminetetraacetate on the survival of X-irradiated rats. Int J Radiat Biol Rel Stud Phys Chem Med. 3(4):439–442.
   PubMed Web of Science ®Google Scholar
• Rosenstein BS, Held KD, Rockwell S, Williams JP, Zeman EM. 2009. American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in U.S. and Canadian radiation oncology residency programs. Int J Radiat Oncol Biol Phys. 75:896–905.
   PubMed Web of Science ®Google Scholar
• Rubin P. 1995. Special issue: late effects of normal tissues (LENT) consensus conference, including RTOG/EORTC SOMA scales. San Francisco, California, August 26–28, 1992. Int J Radiat Oncol Biol Phys. 31:1035–1360.
   PubMed Web of Science ®Google Scholar
• Saada HN, Said UZ, Mahdy EM, Elmezayen HE, Shedid SM. 2014. Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain. Int J Radiat Biol. 90(12):1179–1183.
   PubMed Web of Science ®Google Scholar
• Sabel M, Kalm M, Bjork-Eriksson T, Lannering B, Blomgren K. 2017. Hypothermia after cranial irradiation protects neural progenitor cells in the subventricular zone but not in the hippocampus. Int J Radiat Biol. 93:771–783.
   PubMed Web of Science ®Google Scholar
• Schaue D, Micewicz ED, Ratikan JA, Xie MW, Cheng G, McBride WH. 2015. Radiation and inflammation. Semin Radiat Oncol. 25:4–10.
   PubMed Web of Science ®Google Scholar
• Schoeters GE, Maisin JR, Vanderborght OL. 1991. Protracted treatment of C57B1 mice with Zn-DTPA after 241Am injection reduces the long-term radiation effects. Int J Radiat Biol. 59:1027–1038.
   PubMed Web of Science ®Google Scholar
• Schubauer-Berigan MK, Daniels RD, Fleming DA, Markey AM, Couch JR, Ahrenholz SH, Burphy JS, Anderson JL, Tseng CY. 2007. Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature. Br J Haematol. 139:799–808.
   PubMed Web of Science ®Google Scholar
• Seed TM, Inal CE, Singh VK. 2014. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. Int J Radiat Biol. 90(7):594–604.
   PubMed Web of Science ®Google Scholar
• Sharma R, Tiku AB. 2014. Emodin, an anthraquinone derivative, protects against gamma radiation-induced toxicity by inhibiting DNA damage and oxidative stress. Int J Radiat Biol. 90(4):275–283.
   PubMed Web of Science ®Google Scholar
• Shore RE. 1990. Occupational radiation studies: status, problems, and prospects. Health Phys. 59:63–68.
   PubMed Web of Science ®Google Scholar
• Singh M, Alavi A, Wong R, Akita S. 2016. Radiodermatitis: a review of our current understanding. Am J Clin Dermatol. 17:277–292.
   PubMed Web of Science ®Google Scholar
• Singh VK, Garcia M, Seed TM. 2017a. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status. Int J Radiat Biol. 93:870–884.
   PubMed Web of Science ®Google Scholar
• Singh VK, Hanlon BK, Santiago PT, Seed TM. 2017b. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with ‘standard of care’ medicinal and procedures not requiring regulatory approval for use. Int J Radiat Biol. 93:885–906.
   PubMed Web of Science ®Google Scholar
• Singh VK, Seed TM. 2017. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. Int J Radiat Biol. 93:851–869.
   PubMed Web of Science ®Google Scholar
• Smith ST, Claycamp HG. 1988. Enhanced survival of gamma-irradiated Escherichia coli following pretreatment with dithiothreitol. Int J Radiat Biol Rel Stud Phys Chem Med. 53(5):829–837.
   PubMedGoogle Scholar
• Smoliar V, Betz EH. 1963. Effect of cystamine and cysteamine on X-irradiated hair follicles. Int J Radiat Biol Rel Stud Phys Chem Med. 7(2):145–150.
   PubMed Web of Science ®Google Scholar
• Solen G, Edgren M, Scott OC, Revesz L. 1990. Radiosensitization by oxygen and radioprotection by thiols: analysis of the combined action according to a modified competition model. Int J Radiat Biol. 57(5):959–969.
   PubMed Web of Science ®Google Scholar
• Solen G, Edgren M, Scott OC, Revesz L. 1991. Radioprotection by dithiothreitol (DTT) at varying oxygen concentrations: predictions of a modified competition model and theory evaluation. Int J Radiat Biol. 59(2):409–418.
   PubMed Web of Science ®Google Scholar
• Soltani B, Bodaghabadi N, Ghaemi N, Sadeghizadeh M. 2017. Radiation-induced surge of macrophage foam cell formation, oxidative damage, and cytokine release is attenuated by a nanoformulation of curcumin. Int J Radiat Biol. 93(3):303–314.
   PubMed Web of Science ®Google Scholar
• Sowa MB, Goetz W, Baulch JE, Pyles DN, Dziegielewski J, Yovino S, Snyder AR, de Toledo SM, Azzam EI, Morgan WF. 2010. Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells. Int J Radiat Biol. 86:102–113.
   PubMed Web of Science ®Google Scholar
• Stradling GN, Gray SA, Moody JC, Hodgson A, Raymond KN, Durbin PW, Rodgers SJ, White DL, Turowski PN. 1991. The efficacy of DFO-HOPO, DTPA-DX and DTPA for enhancing the excretion of plutonium and ameriicum from the rat. Int J Radiat Biol. 59(5):1269–1277.
   PubMed Web of Science ®Google Scholar
• Stradling GN, Stather JW, Gray SA, Moody JC, Ellender M, Hodgson A, Volf V, Taylor DM, Wirth P, Gaskin PW. 1989. The efficacies of pure LICAM(C) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate. Int J Radiat Biol. 56(4):503–514.
   PubMed Web of Science ®Google Scholar
• Starkie CM. 1961. The effect of cysteamine on the survival of foetal germ cells after irradiation. Int J Radiat Biol Relat Stud Phys Chem Med. 3:609–617.
   PubMed Web of Science ®Google Scholar
• Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, et al. 2004. Meeting report. Models for evaluating agents intended for prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI workshop, December 3–4, 2003. Radiat Res. 162:711–728.
   PubMed Web of Science ®Google Scholar
• Stratton K, Davis EM. 1962. The radioprotective action of guanylthiourea and related compounds. Int J Radiat Biol Relat Stud Phys Chem Med. 5:105–121.
   PubMed Web of Science ®Google Scholar
• Sumikawa S, Watanabe S, Tanaka M, Tanaka A, Araki H. 2017. Effect of basic fibroblast growth factor on radiation-induced oral mucositis in male Syrian hamsters. Int J Radiat Biol. 93:1343–1349.
   PubMed Web of Science ®Google Scholar
• Sun LR, Cooper S. 2018. Neurological complications of the treatment of pediatric neoplastic disorders. Pediatr Neurol. 85:33–42.
   PubMed Web of Science ®Google Scholar
• Supek Z, Randic M, Lovasen Z. 1961. Radioprotective action of some indolealkylamines. Int J Radiat Biol Rel Stud Phys Chem Med. 4(1):111–112.
   Google Scholar
• Szot Z, Rochalska M, Chomiczewski K, Chimiak A, Przychodzen W. 1989. Efficacy and toxicity of N,N',N",N"'-tetra(2,3,4-trihydroxybenzoyl)-spermine for decorporation of 239Pu from mice. Int J Radiat Biol. 55(1):141–149.
   PubMed Web of Science ®Google Scholar
• Szumiel I. 2012. Radiation hormesis: autophagy and other cellular mechanisms. Int J Radiat Biol. 88:619–628.
   PubMed Web of Science ®Google Scholar
• Taibi R, Lleshi A, Barzan L, Fiorica F, Leghissa M, Vaccher E, De Paoli P, Franchin G, Berretta M, Tirelli U. 2014. Head and neck cancer survivors patients and late effects related to oncologic treatment: update of literature. Eur Rev Med Pharmacol Sci. 18:1473–1481.
   PubMed Web of Science ®Google Scholar
• Talebpour Amiri F, Hamzeh M, Naeimi RA, Ghasemi A, Hosseinimehr SJ. 2018. Radioprotective effect of atorvastatin against ionizing radiation-induced nephrotoxicity in mice. Int J Radiat Biol. 94:106–113.
   PubMed Web of Science ®Google Scholar
• Thekkekkara D, Basavan D, Chandna S, Nanjan MJ. 2018. A combination of resveratrol and 3,3'-diindolylmethane, a potent radioprotector. Int J Radiat Biol. 94(6):558–568.
   PubMed Web of Science ®Google Scholar
• Tokat AO, Akbulut A, Billur D, Koca G, Bayram P, Kuru S, Karasu S, Aydogmus S, Cakmak H, Ozmert S et al. 2018. Montelukast attenuates radioactive I131-induced pulmonary damage on rats. Int J Radiat Biol. 94(6):542–550.
   PubMed Web of Science ®Google Scholar
• Truta-Popa LA, Hofmann W, Fakir H, Cosma C. 2011. The effect of non-targeted cellular mechanisms on lung cancer risk for chronic, low level radon exposures. Int J Radiat Biol. 87:944–953.
   PubMed Web of Science ®Google Scholar
• van Bekkum DW, Nieuwerkerk HTM. 1963. The radioprotective action of a number of cysteamine derivatives and related compounds. Int J Radiat Biol Rel Stud Phys Chem Med. 7(5):473–479.
   PubMed Web of Science ®Google Scholar
• van den Brenk HAS, Haas M. 1961. Studies of mechanisms of chemical radiation protection in vivo. I. 5-hydroxytryptamine in relation to effect of antimetabolites, antagonists and releasing agents. Int J Radiat Biol Rel Stud Phys Chem Med. 3(1):73–94.
   PubMed Web of Science ®Google Scholar
• van den Aardweg GJ, Hopewell JW, Adams GE, Barnes DW, Sansom JM, Stratford IJ, Nethersell AB. 1991. Protection of pig epidermis against radiation-induced damage by the infusion of BW12C. Int J Radiat Biol. 59:1039–1051.
   PubMed Web of Science ®Google Scholar
• van den Hoek J. 1989. European research on the transfer of radionuclides to animals-a historical perspective. Sci Total Environ. 85:17–27.
   PubMed Web of Science ®Google Scholar
• van der Meer C, van Bekkum DW. 1959. The mechanism of radiation protection by histamine and other biological amines. Int J Rad Biol Rel Stud Phys Chem Med. 1:5–23.
   Web of Science ®Google Scholar
• van der Meer C, Valkenburg PW, Remmelts M. 1963. Experiments on the radioprotective action of dimethyl sulphoxide. Int J Radiat Biol Rel Stud Phys Chem Med. 6(2):151–155.
   PubMed Web of Science ®Google Scholar
• van der Meer C, van Bekkum DW. 1961. A study on the mechanism of radiation protection by 5-hydroxytryptamine and tryptamine. Int J Radiat Biol. 4(1):105–110.
   Web of Science ®Google Scholar
• Varghese JJ, Schmale IL, Mickelsen D, Hansen ME, Newlands SD, Benoit DSW, Korshunov VA, Ovitt CE. 2018. Localized delivery of amifostine enhances salivary gland radioprotection. J Dent Res. 97:1252–1259.
   PubMed Web of Science ®Google Scholar
• Varshney R, Kale RK. 1990. Effects of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radiat Biol. 58(5):733–743.
   PubMed Web of Science ®Google Scholar
• Vasilyeva I, Bespalov V, Baranova A. 2015. Radioprotective combination of alpha-tocopherol and ascorbic acid promotes apoptosis that is evident by release of low-molecular weight DNA fragments into circulation. Int J Radiat Biol. 91(11):872–877.
   PubMed Web of Science ®Google Scholar
• Vergroesen AJ, Budke L, Vos O. 1963. Protection of tissue-culture cells against ionizing radiation. III. The influence of anoxia on the radioprotection of tissue-culture cells by cysteamine. Int J Rad Biol Rel Stud Phys Chem Med. 6:117–126.
   Web of Science ®Google Scholar
• Verma S, Gupta ML. 2015. Radiation-induced hematopoietic myelosuppression and genotoxicity get significantly countered by active principles of Podophyllum hexandrum: a study in strain 'A' mice. Int J Radiat Biol. 91(9):757–770.
   PubMed Web of Science ®Google Scholar
• Vos O, Kaalen M. 1962. Protection of tissue culture cells against radiation. II. The activity of hypoxia, dimethyl sulphoxide, dimethyl sulphone, glycerol and cysteamine at room temperature and at -196 °C. Int J Rad Biol Rel Stud Phys Chem Med. 5:609–621.
   Web of Science ®Google Scholar
• Vos O, Roos-Verhey WS. 1988. Radioprotection by glutathione esters and cysteamine in normal and glutathione-depleted mammalian cells. Int J Radiat Biol. 53(2):273–281.
   Web of Science ®Google Scholar
• Wai ES, Lesperance M, Lu L, Alexander CS, Truong PT. 2017. Effect of referral patterns and treatment type on oncologic outcomes for women with ductal carcinoma in situ. Cureus. 9:e1128.
   PubMed Web of Science ®Google Scholar
• Wang R, Han L, Gao Q, Chen D, Wang Y, Zhang X, Yu X, Zhang Y, Li Z, Bai C. 2018. Progress on active analgesic components and mechanisms of commonly used traditional Chinese medicines: a comprehensive review. J Pharm Pharm Sci. 21:437–480.
   PubMed Web of Science ®Google Scholar
• Watanabe S, Suemaru K, Nakanishi M, Nakajima N, Tanaka M, Tanaka A, Araki H. 2014. Assessment of the hamster cheek pouch as a model for radiation-induced oral mucositis, and evaluation of the protective effects of keratinocyte growth factor using this model. Int J Radiat Biol. 90:884–891.
   PubMed Web of Science ®Google Scholar
• Webman EJ, Edlin G, Mower HF. 1989. Free radical scavenging activity of papaya juice. Int J Radiat Biol. 55(3):347–351.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Kumar KS, Walden TL, Neta R, Landauer MR, Clark EP. 1990. Advances in radioprotection through the use of combined agent regimens. Int J Radiat Biol. 57:709–722.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Landauer MR. 2003. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 189:1–20.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Landauer MR. 2009. History and development of radiation-protective agents. Int J Radiat Biol. 85:539–573.
   PubMed Web of Science ®Google Scholar
• Weiss L. 1961. The effect of cysteamine on the radiosensitivity of the haemopoietic system of severely hypoxic mice. Int J Radiat Biol Relat Stud Phys Chem Med. 3:285–292.
   PubMed Web of Science ®Google Scholar
• Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. 2003. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. 13:182–188.
   PubMed Web of Science ®Google Scholar
• Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, et al. 2010. Animal models for medical countermeasures to radiation exposure. Radiat Res. 173:557–578.
   PubMed Web of Science ®Google Scholar
• Williams JP, Calvi L, Chakkalakal JV, Finkelstein JN, O’Banion MK, Puzas E. 2016. Addressing the symptoms or fixing the problem? Developing countermeasures against normal tissue radiation injury. Radiat Res. 186:1–16.
   PubMed Web of Science ®Google Scholar
• Williams JP, McBride WH. 2011. After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol. 87:851–868.
   PubMed Web of Science ®Google Scholar
• Williams JP, Newhauser W. 2018. Normal tissue damage: its importance, history and challenges for the future. Br J Radiol. 20180048. [Epub ahead of print].
   PubMed Web of Science ®Google Scholar
• Withers HR, Thames HD, Jr, Peters LJ. 1982. Differences in the fractionation response of acutely and late-responding tissues. In: Karcher KH, editor. Progress in radio-oncology. New York (NY): Raven Press; p. 287–296.
   Google Scholar
• Wu SG, Tuboi A, Miyamoto T. 1989. Radioprotection of C3H mice by recombinant human interleukin-1 alpha. Int J Radiat Biol. 56(4):485–492.
   PubMed Web of Science ®Google Scholar
• Yang P, Cheville AL, Wampfler JA, Garces YI, Jatoi A, Clark MM, Cassivi SD, Midthun DE, Marks RS, Aubry MC, et al. 2012. Quality of life and symptom burden among long-term lung cancer survivors. J Thorac Oncol. 7:64–70.
   PubMed Web of Science ®Google Scholar
• Yuhas JM, Storer JB. 1969. Chemoprotection against three modes of radiation death in the mouse. Int J Radiat Biol Relat Stud Phys Chem Med. 15:233–237.
   PubMed Web of Science ®Google Scholar
• Zatz LM. 1963. The radioprotective effects of combined hypoxia and AET in mice. Int J Radiat Biol Relat Stud Phys Chem Med. 6:105–115.
   PubMed Web of Science ®Google Scholar
• Zhang X, Ye C, Sun F, Wei W, Hu B, Wang J. 2016. Both complexity and location of DNA damage contribute to cellular senescence induced by ionizing radiation. PLoS One. 11:e0155725.
   PubMed Web of Science ®Google Scholar
• Zhao W, Robbins ME. 2009. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem. 16:130–143.
   PubMed Web of Science ®Google Scholar