Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury

References

• Abernathy LM, Fountain MD, Joiner MC, Hillman GG. 2017. Innate immune pathways associated with lung radioprotection by soy isoflavones. Front Oncol. 7:7.
   PubMed Web of Science ®Google Scholar
• Abrams HL. 1951. Influence of age, body weight, and sex on susceptibility of mice to the lethal effects of x-radiation. Proc Soc Exp Biol Med. 76(4):729–732.
   PubMed Web of Science ®Google Scholar
• Ader R, Hahn EW. 1963. Effects of social environment on mortality to whole body x-irradiation in the rat. Psychol Rep. 13(1):211–215E.
   Web of Science ®Google Scholar
• Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corley K, O’Leary BR, Spitz DR, Buatti JM, et al. 2018. Pharmacologic ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Res. 78(24):6838–6851.
   PubMed Web of Science ®Google Scholar
• Augenlicht L. 2014. Hidden effects of mouse chow. Science. 346(6210):710.
   PubMed Web of Science ®Google Scholar
• Bache ST, Juang T, Belley MD, Koontz BF, Adamovics J, Yoshizumi TT, Kirsch DG, Oldham M. 2015. Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters. Med Phys. 42(2):846–855.
   PubMed Web of Science ®Google Scholar
• Bagheri H, Rezapour S, Najafi M, Motevaseli E, Shekarchi B, Cheki M, Mozdarani H. 2018. Protection against radiation-induced micronuclei in rat bone marrow erythrocytes by curcumin and selenium L-methionine. Iran J Med Sci. 43(6):645–652.
   PubMed Web of Science ®Google Scholar
• Balcombe JP, Barnard ND, Sandusky C. 2004. Laboratory routines cause animal stress. Contemp Top Lab Anim Sci. 43(6):42–51.
   PubMedGoogle Scholar
• Bentz BZ, Chavan AV, Lin D, Tsai EH, Webb KJ. 2016. Fabrication and application of heterogeneous printed mouse phantoms for whole animal optical imaging. Appl Opt. 55(2):280–287.
   PubMed Web of Science ®Google Scholar
• Bewick V, Cheek L, Ball J. 2004. Statistics review 12: survival analysis. Crit Care. 8(5):389–394.
   PubMed Web of Science ®Google Scholar
• Bhatia AL, Sharma A, Patni S, Sharma AL. 2007. Prophylactic effect of flaxseed oil against radiation-induced hepatotoxicity in mice. Phytother Res. 21(9):852–859.
   PubMed Web of Science ®Google Scholar
• Booth C, Tudor G, Tudor J, Katz BP, MacVittie TJ. 2012. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 103(4):383–399.
   PubMed Web of Science ®Google Scholar
• Brady SL, Yoshizumi TT, Anderson-Evans C, Nguyen G. 2012. Isodose curve mappings measured while undergoing rotation for quality assurance testing of a 137Cs irradiator. Health Phys. 102(Suppl 1):S8–S12.
   PubMedGoogle Scholar
• Brodin NP, Chen Y, Yaparpalvi R, Guha C, Tomé WA. 2016. Dosimetry formalism and implementation of a homogenous irradiation protocol to improve the accuracy of small animal whole-body irradiation using a 137Cs irradiator. Health Phys. 110(2 Suppl 1):S26–S38.
   PubMed Web of Science ®Google Scholar
• Brook I, Elliott TB, Ledney GD, Shoemaker MO, Knudson GB. 2004. Management of postirradiation infection: lessons learned from animal models. Mil Med. 169(3):194–197.
   PubMed Web of Science ®Google Scholar
• Brown NM, Setchell KD. 2001. Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones. Lab Invest. 81(5):735–747.
   PubMed Web of Science ®Google Scholar
• Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, et al. 2016. Citrulline as a biomarker for gastrointestinal-acute radiation syndrome: species differences and experimental condition effects. Radiat Res. 186(1):71–78.
   PubMed Web of Science ®Google Scholar
• Bunin DI, Bakke J, Green CE, Javitz HS, Fielden M, Chang PY. 2020. Romiplostim (Nplate®) as an effective radiation countermeasure to improve survival and platelet recovery in mice. Int J Radiat Biol. 96(1):145–154.
   Web of Science ®Google Scholar
• Caro AC, Hankenson FC, Marx JO. 2013. Comparison of thermoregulatory devices used during anesthesia of C57BL/6 mice and correlations between body temperature and physiologic parameters. J Am Assoc Lab Anim Sci. 52(5):577–583.
   PubMed Web of Science ®Google Scholar
• Cerri M, Tinganelli W, Negrini M, Helm A, Scifoni E, Tommasino F, Sioli M, Zoccoli A, Durante M. 2016. Hibernation for space travel: impact on radioprotection. Life Sci Space Res. 11:1–9.
   Google Scholar
• Changizi V, Haeri SA, Abbasi S, Rajabi Z, Mirdoraghi M. 2019. Radioprotective effects of vitamin A against gamma radiation in mouse bone marrow cells. MethodsX. 6:714–717.
   PubMed Web of Science ®Google Scholar
• Chapman CD, Benedict C, Schioth HB. 2018. Experimenter gender and replicability in science. Sci Adv. 4(1):e1701427.
   PubMed Web of Science ®Google Scholar
• Christian JJ, Williamson HO. 1958. Effect of crowding on experimental granuloma formation in mice. Proc Soc Exp Biol Med. 99(2):385–387.
   PubMed Web of Science ®Google Scholar
• Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, Grieshaber PA, Solomides CC, Cengel KA. 2012. Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG). Radiat Res. 178(6):568–580.
   PubMed Web of Science ®Google Scholar
• Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, Arguiri E, Heitjan DF, Solomides CC, Cengel KA. 2011. Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer. 11:269.
   PubMed Web of Science ®Google Scholar
• Christy AC, Byrnes KR, Settle TL. 2014. Evaluation of medicated gel as a supplement to providing acetaminophen in the drinking water of C57BL/6 mice after surgery. J Am Assoc Lab Anim Sci. 53(2):180–184.
   PubMed Web of Science ®Google Scholar
• Collins FS, Tabak LA. 2014. Policy: NIH plans to enhance reproducibility. Nature. 505(7485):612–613.
   PubMed Web of Science ®Google Scholar
• Conere TJ, Church SW, Lowry WS. 1986. The radioprotective role of common anaesthetic and other narcotic agents. Radiother Oncol. 5(4):347–348.
   PubMed Web of Science ®Google Scholar
• Crawford PA, Gordon JI. 2005. Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci USA. 102(37):13254–13259.
   PubMed Web of Science ®Google Scholar
• Crosfill ML, Lindop PJ, Rotblat J. 1959. Variation of sensitivity to ionizing radiation with age. Nature. 183(4677):1729–1730.
   PubMed Web of Science ®Google Scholar
• Dainiak N. 2018. Medical management of acute radiation syndrome and associated infections in a high-casualty incident. J Radiat Res. 59(suppl_2):ii54–ii64.
   PubMedGoogle Scholar
• Daniali H, Flaten MA. 2019. A qualitative systematic review of effects of provider characteristics and nonverbal behavior on pain, and placebo and nocebo effects. Front Psychiatry. 10:242.
   PubMed Web of Science ®Google Scholar
• Day RM, Barshishat-Kupper M, Mog SR, McCart EA, Prasanna PG, Davis TA, Landauer MR. 2008. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res. 49(4):361–372.
   PubMed Web of Science ®Google Scholar
• DiCarlo AL, White NC, Litovitz TA. 2001. Mechanical and electromagnetic induction of protection against oxidative stress. Bioelectrochem. 53(1):87–95.
   PubMed Web of Science ®Google Scholar
• Ding J, Wang H, Wu ZB, Zhao J, Zhang S, Li W. 2015. Protection of murine spermatogenesis against ionizing radiation-induced testicular injury by a green tea polyphenol. Biol Reprod. 92(1):6.
   PubMed Web of Science ®Google Scholar
• Down JD, Collis CH, Jeffery PK, Steel GG. 1983. The effects of anesthetics and misonidazole on the development of radiation-induced lung damage in mice. Int J Radiat Oncol Biol Phys. 9(2):221–226.
   PubMed Web of Science ®Google Scholar
• Duncan AM, Ronen A, Blakey DH. 1983. Diurnal variation in the response of gamma-ray-induced apoptosis in the mouse intestinal epithelium. Cancer Lett. 21(2):163–166.
   PubMed Web of Science ®Google Scholar
• El-Missiry M, Othman A, Alabdan M. 2012. Melatonin for protection against ionizing radiation. In: Nenoi M, editor. Current topics in ionizing radiation research. InTech.
   Google Scholar
• Empey LR, Papp JD, Jewell LD, Fedorak RN. 1992. Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats. Dig Dis Sci. 37(2):205–214.
   PubMed Web of Science ®Google Scholar
• Ericsson AC, Davis JW, Spollen W, Bivens N, Givan S, Hagan CE, McIntosh M, Franklin CL. 2015. Effects of vendor and genetic background on the composition of the fecal microbiota of inbred mice. PLoS One. 10(2):e0116704.
   PubMed Web of Science ®Google Scholar
• Erol FS, Topsakal C, Ozveren MF, Kaplan M, Ilhan N, Ozercan IH, Yildiz OG. 2004. Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study. Neurosurg Rev. 27(1):65–69.
   PubMed Web of Science ®Google Scholar
• Farese AM, Cohen MV, Katz BP, Smith CP, Jackson W, 3rd, Cohen DM, MacVittie TJ. 2012. A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management. Health Phys. 103(4):367–382.
   PubMed Web of Science ®Google Scholar
• Fish BL, MacVittie TJ, Szao A, Moulder JE, Medhora M. 2018. WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP). Int J Radiat Biol. 96(1):81–92.
   Web of Science ®Google Scholar
• Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR. 2011. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis. 52(4):e56–e93.
   PubMed Web of Science ®Google Scholar
• Frölén H, Lüning KG, Rönnbäck C, Frolen H, Luning KG, Ronnback C. 1961. The effect of x-irradiation on various mouse strains due to their genetic backgroun. I. Lethality after acute irradation. Radiat Res. 14(4):381–393.
   PubMedGoogle Scholar
• Fucic A, Gamulin M. 2011. Interaction between ionizing radiation and estrogen: what we are missing? Med Hypotheses. 77(6):966–969.
   PubMed Web of Science ®Google Scholar
• Garrett J, Sampson CH, Plett PA, Crisler R, Parker J, Venezia R, Chua HL, Hickman DL, Booth C, MacVittie T, et al. 2019. Characterization and etiology of swollen muzzles in irradiated mice. Radiat Res. 191(1):31–42.
   PubMed Web of Science ®Google Scholar
• Gaskill BN, Gordon CJ, Pajor EA, Lucas JR, Davis JK, Garner JP. 2012. Heat or insulation: behavioral titration of mouse preference for warmth or access to a nest. PLoS One. 7(3):e32799.
   PubMed Web of Science ®Google Scholar
• Gavrilov V, Leibovich Y, Ariad S, Lavrenkov K, Shany S. 2010. A combined pretreatment of 1,25-dihydroxyvitamin D3 and sodium valproate enhances the damaging effect of ionizing radiation on prostate cancer cells. J Steroid Biochem Mol Biol. 121(1–2):391–394.
   PubMed Web of Science ®Google Scholar
• Giles K, Guan C, Jagoe TR, Mazurak V. 2016. Diet composition as a source of variation in experimental animal models of cancer cachexia. J Cachexia Sarcopenia Muscle. 7(2):110–125.
   PubMed Web of Science ®Google Scholar
• Gordon CJ. 2004. Effect of cage bedding on temperature regulation and metabolism of group-housed female mice. Comp Med. 54(1):63–68.
   PubMed Web of Science ®Google Scholar
• Gouveia K, Hurst JL. 2013. Reducing mouse anxiety during handling: effect of experience with handling tunnels. PLoS One. 8(6):e66401
   PubMed Web of Science ®Google Scholar
• Grahn D. 1958. Acute radiation response of mice from a cross between radiosensitive and radioresistant strains. Genetics. 43(5):835–843.
   PubMedGoogle Scholar
• Grahn D, Hamilton KF. 1957. Genetic variation in the acute lethal response of four inbred mouse strains to whole body x-irradiation. Genetics. 42(3):189–198.
   PubMed Web of Science ®Google Scholar
• Grahn D, Sacher GA. 1958. Chronic radiation mortality in mice after single whole-body exposure to 250-, 135-, and 80-kvp x-rays. Radiat Res. 8(2):187–194.
   PubMed Web of Science ®Google Scholar
• Hahn EW, Howland JW. 1963. Modification of irradiation response of female rats by population density. Radiat Res. 19(4):676–681.
   PubMed Web of Science ®Google Scholar
• Hamilton KF, Sacher GA, Grahn D. 1963. A sex difference in mouse survival under daily gamma irradiation and its modification by gonadectomy. Radiat Res. 18:12–16.
   PubMed Web of Science ®Google Scholar
• Hammersberg P, Stenstrom M, Hedtjarn H, Mangard M. 1998. Image noise in X-ray imaging caused by radiation scattering and source leakage, a qualitative and quantitative analysis. J Xray Sci Technol. 8(1):19–29.
   PubMedGoogle Scholar
• Hankenson FC. 2014. Critical care management for laboratory mice and rats. Boca Raton (FL): CRC Press.
   Google Scholar
• Hankey KG, Farese AM, Blaauw EC, Gibbs AM, Smith CP, Katz BP, Tong Y, Prado KL, MacVittie TJ. 2015. Pegfilgrastim improves survival of lethally irradiated nonhuman primates. Radiat Res. 183(6):643–655.
   PubMed Web of Science ®Google Scholar
• Harapanhalli RS, Narra VR, Yaghmai V, Azure MT, Goddu SM, Howell RW, Rao DV. 1994. Vitamins as radioprotectors in vivo. II. Protection by vitamin A and soybean oil against radiation damage caused by internal radionuclides. Radiat Res. 139(1):115–122.
   PubMed Web of Science ®Google Scholar
• Haus E. 2002. Chronobiology of the mammalian response to ionizing radiation. Potential applications in oncology. Chronobiol Int. 19(1):77–100.
   PubMed Web of Science ®Google Scholar
• Henshaw PS. 1944. Experimental Roentgen injury: II. Changes produced with intermediate-range doses and a comparison of the relative susceptibility of different kinds of animals. J Nat Cancer Inst. 4:477–484.
   Google Scholar
• Hess SE, Rohr S, Dufour BD, Gaskill BN, Pajor EA, Garner JP. 2008. Home improvement: C57BL/6J mice given more naturalistic nesting materials build better nests. J Am Assoc Lab Anim Sci. 47(6):25–31.
   PubMed Web of Science ®Google Scholar
• Hillman GG, Singh-Gupta V, Runyan L, Yunker CK, Rakowski JT, Sarkar FH, Miller S, Gadgeel SM, Sethi S, Joiner MC, et al. 2011. Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury. Radiother Oncol. 101(2):329–336.
   PubMed Web of Science ®Google Scholar
• Hoggatt AF, Hoggatt J, Honerlaw M, Pelus LM. 2010. A spoonful of sugar helps the medicine go down: a novel technique to improve oral gavage in mice. J Am Assoc Lab Anim Sci. 49(3):329–334.
   PubMed Web of Science ®Google Scholar
• Hursh JB, Casarett GW. 1956. The lethal effect of acute x-irradiation on rats as a function of age. Br J Radiol. 29(339):169–171.
   PubMed Web of Science ®Google Scholar
• Ibbott G, Ma CM, Rogers DW, Seltzer SM, Williamson JF. 2008. Anniversary paper: fifty years of AAPM involvement in radiation dosimetry. Med Phys. 35(4):1418–1427.
   PubMed Web of Science ®Google Scholar
• Ijiri K, Potten CS. 1988. Circadian rhythms in the incidence of apoptotic cells and number of clonogenic cells in intestinal crypts after radiation using normal and reversed light conditions . Int J Radiat Biol Relat Stud Phys Chem Med. 53(5):717–727.
   PubMedGoogle Scholar
• Ijiri K, Potten CS. 1990. The circadian rhythm for the number and sensitivity of radiation-induced apoptosis in the crypts of mouse small intestine. Int J Radiat Biol. 58(1):165–175.
   PubMed Web of Science ®Google Scholar
• Ilnytskyy Y, Zemp FJ, Koturbash I, Kovalchuk O. 2008. Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun. 377(1):41–45.
   PubMed Web of Science ®Google Scholar
• Jackson IL, Zhang Y, Bentzen SM, Hu J, Zhang A, Vujaskovic Z. 2016. Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse. Sci Rep. 6:36579.
   PubMed Web of Science ®Google Scholar
• Jafari E, Alavi M, Zal F. 2018. The evaluation of protective and mitigating effects of vitamin C against side effects induced by radioiodine therapy. Radiat Environ Biophys. 57(3):233–240.
   PubMed Web of Science ®Google Scholar
• Jaffray DA. 2007. Image-guided radiation therapy: from concept to practice. Semin Radiat Oncol. 17(4):243–244.
   PubMed Web of Science ®Google Scholar
• Jones JW, Alloush J, Sellamuthu R, Chua HL, MacVittie TJ, Orschell CM, Kane MA. 2019. Effect of sex on biomarker response in a mouse model of the hematopoietic acute radiation syndrome. Health Phys. 116(4):484–502.
   PubMed Web of Science ®Google Scholar
• Jones DC, Osborn GK, Kimeldorf DJ. 1969. Age at x-irradiation and acute radiation mortality in the adult male rat. Radiat Res. 38(3):614–621.
   PubMed Web of Science ®Google Scholar
• Kallman RF, Kohn HI. 1956. The influence of strain on acute x-ray lethality in the mouse. I. LD50 and death rate studies. Radiat Res. 5(4):309–317.
   PubMed Web of Science ®Google Scholar
• Kanter M, Akpolat M. 2008. Vitamin C protects against ionizing radiation damage to goblet cells of the ileum in rats. Acta Histochem. 110(6):481–490.
   PubMed Web of Science ®Google Scholar
• Kappel S, Hawkins P, Mendl MT. 2017. To group or not to group? Good practice for housing male laboratory mice. Animals. 7(12):88.
   Web of Science ®Google Scholar
• Karbownik M, Reiter RJ. 2000. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proc Soc Exp Biol Med. 225(1):9–22.
   PubMed Web of Science ®Google Scholar
• Kazi AM, MacVittie TJ, Lasio G, Lu W, Prado KL. 2014. The MCART radiation physics core: the quest for radiation dosimetry standardization. Health Phys. 106(1):97–105.
   PubMed Web of Science ®Google Scholar
• Keizer HJ, van Putten LM. 1976. The radioprotective action on bone marrow CFU during immobilization of mice. Radiat Res. 66(2):326–336.
   PubMed Web of Science ®Google Scholar
• Fukumoto R, Burns TM, Kiang JG. 2014. Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma. PLoS One. 9(2):e90448.
   PubMed Web of Science ®Google Scholar
• Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8(6):e1000412.
   PubMed Web of Science ®Google Scholar
• Kim C, Kim S-K, Kim IH, Kim S-i, Kim YS, Kang SH, Moon SH, Kim T-S. 2010. Comparison of retro-orbital, intraperitoneal, intravenous and per-oral routes for F-18 FDG administration in mouse tumor models. J Nucl Med. 51(2):448–448.
   PubMedGoogle Scholar
• Knoll GF. 2000. Radiation detection and measurement. 3rd ed. New York: Wiley.
   Google Scholar
• Kohn HI, Kallman RF. 1957. The influence of strain on acute x-ray lethality in the mouse. II. Recovery rate studies. Radiat Res. 6(3):329–338.
   PubMed Web of Science ®Google Scholar
• Konopacka M, Widel M, Rzeszowska-Wolny J. 1998. Modifying effect of vitamins C, E and beta-carotene against gamma-ray-induced DNA damage in mouse cells. Mutat Res. 417(2–3):85–94.
   PubMed Web of Science ®Google Scholar
• Koturbash I, Zemp F, Kolb B, Kovalchuk O. 2011. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res. 722(2):114–118.
   PubMed Web of Science ®Google Scholar
• Kovalchuk O, Burke P, Besplug J, Slovack M, Filkowski J, Pogribny I. 2004. Methylation changes in muscle and liver tissues of male and female mice exposed to acute and chronic low-dose X-ray-irradiation. Mutat Res. 548(1–2):75–84.
   PubMed Web of Science ®Google Scholar
• Kovalchuk O, Ponton A, Filkowski J, Kovalchuk I. 2004. Dissimilar genome response to acute and chronic low-dose radiation in male and female mice. Mutat Res. 550(1–2):59–72.
   PubMed Web of Science ®Google Scholar
• Kuskin SM, Wang SC, Rugh R. 1959. Protective effect of artificially induced hibernation against lethal doses of whole body x-irradiation in CF male mice. Am J Physiol. 196(6):1211–1213.
   PubMedGoogle Scholar
• Landauer MR, Harvey AJ, Kaytor MD, Day RM. 2019. Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. J Radiat Res. 60(3):308–317.
   PubMed Web of Science ®Google Scholar
• Landauer MR, Srinivasan V, Seed TM. 2003. Genistein treatment protects mice from ionizing radiation injury. J. Appl. Toxicol. 23(6):379–385.
   PubMed Web of Science ®Google Scholar
• Landes RD, Lensing SY, Kodell RL, Hauer-Jensen M. 2012. Statistical analysis of survival data from radiation countermeasure experiments. Radiat Res. 177(5):546–554.
   PubMed Web of Science ®Google Scholar
• Langberg M, Rotem C, Fenig E, Koren R, Ravid A. 2009. Vitamin D protects keratinocytes from deleterious effects of ionizing radiation. Br J Dermatol. 160(1):151–161.
   PubMed Web of Science ®Google Scholar
• Langendorff H, Koch R. 1954. [Studies of biological radiation protection. VII. The effect of anesthesia on the radiation-injured mouse]. Strahlentherapie. 94(3):411–420.
   PubMedGoogle Scholar
• Langgartner D, Foertsch S, Fuchsl AM, Reber SO. 2017. Light and water are not simple conditions: fine tuning of animal housing in male C57BL/6 mice. Stress. 20(1):10–18.
   PubMed Web of Science ®Google Scholar
• Lee J, Son H, Lee S. 2017. Effect of selenium supplement for protection of salivary glands from I-131 radiation damage in patients with differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 44:S778–S779.
   Web of Science ®Google Scholar
• Leon-Rico D, Fernandez-Garcia M, Aldea M, Sanchez R, Peces-Barba M, Martinez-Palacio J, Yanez RM, Almarza E. 2015. Comparison of haematopoietic stem cell engraftment through the retro-orbital venous sinus and the lateral vein: alternative routes for bone marrow transplantation in mice. Lab Anim. 49(2):132–141.
   PubMedGoogle Scholar
• Levan H, Haas RE, Stefani S, Reyes E. 1970. Radiosensitivity of mice exposed to various temperatures and low-dose rate radiation. Am J Physiol. 219(4):1033–1035.
   PubMedGoogle Scholar
• Lindop PJ, Rotblat J. 1959. Shortening of lifespan of mice as a function of age at irradiation. Gerontologia. 3:122–127.
   PubMedGoogle Scholar
• Lyte M, Opitz N, Goehler LE, Gaykema RP, Overmier JB. 2005. Recommended housing conditions and test procedures can interact to obscure a significant experimental effect. Behav Res Methods. 37(4):651–656.
   PubMed Web of Science ®Google Scholar
• MacVittie TJ. 2012. The MCART Consortium animal models series. Health Phys. 103(4):340–342.
   PubMed Web of Science ®Google Scholar
• MacVittie TJ, Bennett A, Booth C, Garofalo M, Tudor G, Ward A, Shea-Donohue T, Gelfond D, McFarland E, Jackson W, et al. 2012. The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation. Health Phys. 103(4):427–453.
   PubMed Web of Science ®Google Scholar
• Maher RL, Barbash SM, Lynch DV, Swoap SJ. 2015. Group housing and nest building only slightly ameliorate the cold stress of typical housing in female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 308(12):R1070–1079.
   PubMed Web of Science ®Google Scholar
• Marampon F, Gravina GL, Festuccia C, Popov VM, Colapietro EA, Sanita P, Musio D, De Felice F, Lenzi A, Jannini EA, et al. 2016. Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. J Endocrinol Invest. 39(4):411–422.
   PubMed Web of Science ®Google Scholar
• McGurk R, Hadley C, Jackson IL, Vujaskovic Z. 2012. Development and dosimetry of a small animal lung irradiation platform. Health Phys. 103(4):454–462.
   PubMed Web of Science ®Google Scholar
• Moccia KD, Olsen CH, Mitchell JM, Landauer MR. 2010. Evaluation of hydration and nutritional gels as supportive care after total-body irradiation in mice (Mus musculus). J Am Assoc Lab Anim Sci. 49(3):323–328.
   PubMed Web of Science ®Google Scholar
• Moehring F, O'Hara CL, Stucky CL. 2016. Bedding material affects mechanical thresholds, heat thresholds, and texture preference. J Pain. 17(1):50–64.
   PubMed Web of Science ®Google Scholar
• Mortazavi SM, Rahimi S, Mosleh-Shirazi MA, Arjomandi M, Soleimani A, Koohi Hossein-Abadi O, Haghani M, Alavi M. 2015. A comparative study on the life-saving radioprotective effects of vitamins A, E, C and over-the-counter multivitamins. J Biomed Phys Eng. 5(2):59–66.
   PubMedGoogle Scholar
• Nair CK, Devi PU, Shimanskaya R, Kunugita N, Murase H, Gu YH, Kagiya TV. 2003. Water soluble vitamin E (TMG) as a radioprotector. Indian J Exp Biol. 41(12):1365–1371.
   PubMedGoogle Scholar
• Narendran N, Luzhna L, Kovalchuk O. 2019. Sex difference of radiation response in occupational and accidental exposure. Front Genet. 10:260–260.
   PubMed Web of Science ®Google Scholar
• Narra VR, Harapanhalli RS, Howell RW, Sastry KS, Rao DV. 1994. Vitamins as radioprotectors in vivo. I. Protection by vitamin C against internal radionuclides in mouse testes: implications to the mechanism of damage caused by the Auger effect. Radiat Res. 137(3):394–399.
   PubMed Web of Science ®Google Scholar
• Narver HL. 2017. Antimicrobial stewardship in laboratory animal facilities. J Am Assoc Lab Anim Sci. 56(1):6–10.
   PubMed Web of Science ®Google Scholar
• National Research Council Committee. 2011. Guide for the Care and Use of Laboratory Animals. The National Academies Collection: Reports funded by National Institutes of Health. Washington (DC): National Academies Press (US), National Academy of Sciences.
   Google Scholar
• Nayak V, Devi PU. 2005. Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the ocimum flavonoids orientin and vicenin. Radiat Res. 163(2):165–171.
   PubMed Web of Science ®Google Scholar
• Neely C, Lane C, Torres J, Flinn J. 2018. The effect of gentle handling on depressive-like behavior in adult male mice: considerations for Human and Rodent Interactions in the Laboratory. Behav Neurol. 2018:2976014.
   PubMed Web of Science ®Google Scholar
• Nelson RF. 1966. Variation in radiosensitivity of mice with time of day. Acta Radiol Ther Phys Biol. 4(2):91–96.
   PubMed Web of Science ®Google Scholar
• Ohara M, Lu H, Shiraki K, Ishimura Y, Uesaka T, Katoh O, Watanabe H. 2001. Radioprotective effects of miso (fermented soy bean paste) against radiation in B6C3F1 mice: increased small intestinal crypt survival, crypt lengths and prolongation of average time to death. Hiroshima J Med Sci. 50(4):83–86.
   PubMedGoogle Scholar
• Oldfield EH, Friedman R, Kinsella T, Moquin R, Olson JJ, Orr K, DeLuca AM. 1990. Reduction in radiation-induced brain injury by use of pentobarbital or lidocaine protection. J Neurosurg. 72(5):737–744.
   PubMed Web of Science ®Google Scholar
• Palombo P, Moreno-Villanueva M, Mangerich A. 2015. Day and night variations in the repair of ionizing-radiation-induced DNA damage in mouse splenocytes. DNA Repair. 28:37–47.
   PubMed Web of Science ®Google Scholar
• Pannkuk EL, Laiakis EC, Authier S, Wong K, Fornace AJ. Jr. 2015. Global metabolomic identification of long-term dose-dependent urinary biomarkers in nonhuman primates exposed to ionizing radiation. Radiat Res. 184(2):121–133.
   PubMed Web of Science ®Google Scholar
• Parsons PA. 2009. Prospectus. Survival across the fitness-stress continuum under the ecological stress theory of aging: caloric restriction and ionizing radiation. Dose Response. 8(1):4–9.
   PubMed Web of Science ®Google Scholar
• Pearson AE, Phelps TA. 1981. Radiation effects on mouse incisor teeth following whole-body doses of up to 16 gray. Int J Radiat Biol Relat Stud Phys Chem Med. 39(4):409–417.
   PubMed Web of Science ®Google Scholar
• Pellizzon M. 2016. Choice of laboratory animal diet influences intestinal health. Lab Anim. 45(6):238–239.
   Web of Science ®Google Scholar
• Perks JR, Lucero S, Monjazeb AM, Li JJ. 2015. Anthropomorphic phantoms for confirmation of linear accelerator-based small animal irradiation. Cureus. 7(3):e254.
   PubMed Web of Science ®Google Scholar
• Pietrofesa RA, Solomides CC, Christofidou-Solomidou M. 2014. Flaxseed mitigates acute oxidative lung damage in a mouse model of repeated radiation and hyperoxia exposure associated with space exploration. J Pulm Respir Med. 4(6):1000215.
   PubMedGoogle Scholar
• Pizzarello DJ, Isaak D, Chua KE, Rhyne AL. 1964. Circadian rhythmicity in the sensitivity of two strains of mice exposed to whole-body radiation. Science. 145(3629):286–291.
   PubMedGoogle Scholar
• Pizzarello DJ, Isaak D, Witcofski RL, Lyons EA. 1963. Effect of moderate degrees of hypothermia on the sensitivity to whole-body irradiation in adult rats. Radiat Res. 20:203–206.
   PubMed Web of Science ®Google Scholar
• Plett PA, Sampson CH, Chua HL, Jackson W, Vemula S, Sellamuthu R, Fisher A, Feng H, Wu T, MacVittie TJ, et al. 2015. The H-ARS dose response relationship (DRR): Validation and variables. Health Phys. 109(5):391–398.
   PubMed Web of Science ®Google Scholar
• Plett PA, Sampson CH, Chua HL, Joshi M, Booth C, Gough A, Johnson CS, Katz BP, Farese AM, Parker J, et al. 2012. Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome. Health Phys. 103(4):343–355.
   PubMed Web of Science ®Google Scholar
• Pogribny I, Raiche J, Slovack M, Kovalchuk O. 2004. Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes. Biochem Biophys Res Commun. 320(4):1253–1261.
   PubMed Web of Science ®Google Scholar
• Rasmussen TS, de Vries L, Kot W, Hansen LH, Castro-Mejia JL, Vogensen FK, Hansen AK, Nielsen DS. 2019. Mouse vendor influence on the bacterial and viral gut composition exceeds the effect of diet. Viruses. 11(5):435.
   PubMed Web of Science ®Google Scholar
• Reinhard MC, Mirand EA, Goltz HL, Hoffman JG. 1954. Mouse-strain differences in response to radiation. Proc Soc Exp Biol Med. 85(2):367–370.
   PubMed Web of Science ®Google Scholar
• Reiter RJ, Korkmaz A, Ma SR, Rosales-Corral S, Tan DX. 2012. Melatonin protection from chronic, low-level ionizing radiation. Mutat Res Rev Mutat Res. 751(1):7–14.
   PubMed Web of Science ®Google Scholar
• Roche M, Neti P, Kemp FW, Azzam EI, Ferraris RP, Howell RW. 2015. High levels of dietary supplement vitamins A, C and E are absorbed in the small intestine and protect nutrient transport against chronic gamma irradiation. Radiat Res. 184(5):470–481.
   PubMed Web of Science ®Google Scholar
• Roderick TH. 1963. The response of twenty-seven inbred strains of mice to daily doses of whole-body x-rrradiation. Radiat Res. 20(4):631–639.
   PubMed Web of Science ®Google Scholar
• Rosenbaum MD, VandeWoude S, Johnson TE. 2009. Effects of cage-change frequency and bedding volume on mice and their microenvironment. J Am Assoc Lab Anim Sci. 48(6):763–773.
   PubMed Web of Science ®Google Scholar
• Ross WM, Creighton MO, Inch WR, Trevithick JR. 1983. Radiation cataract formation diminished by vitamin E in rat lenses in vitro. Exp Eye Res. 36(5):645–653.
   PubMed Web of Science ®Google Scholar
• Rostami A, Moosavi SAD, Moghadam H, Bolookat ER. 2016. Micronuclei assessment of the radioprotective effects of melatonin and vitamin C in human lymphocytes. Cell J. 18(1):46–51.
   PubMed Web of Science ®Google Scholar
• Rubin NH. 1981. Circadian stage dependence in radiation: response of dividing cells in vivo. Prog Clin Biol Res. 59C(0):151–163.
   PubMedGoogle Scholar
• Russell LB, Russell WL. 1996. Spontaneous mutations recovered as mosaics in the mouse specific-locus test. Proc Natl Acad Sci USA. 93(23):13072–13077.
   PubMed Web of Science ®Google Scholar
• Ryu S-H, Park J-H, Jeong E-S, Choi S-Y, Ham S-H, Park J-I, Jeon H-Y, Kim J-Y, Yoo R-J, Lee Y-J, et al. 2016. Establishment of a mouse model of 70% lethal dose by total-body irradiation. Lab Anim Res. 32(2):116–121.
   PubMedGoogle Scholar
• Sacher GA. 1957. Dependence of acute radiosensitivity on age in adult female mouse. Science. 125(3256):1039–1040.
   PubMed Web of Science ®Google Scholar
• Sacher GA, Grahn D. 1964. Survival of mice under duration-of-life exposure to gamma rays. I. The dosage-survival relation and the lethality function. J Natl Cancer Inst. 32(2):277–321.
   PubMedGoogle Scholar
• Satyamitra MMU, Devi P, Murase H, Kagiya VT. 2003. In vivo postirradiation protection by a vitamin E analog, alpha-TMG. Radiat Res. 160(6):655–661.
   PubMed Web of Science ®Google Scholar
• Satyamitra MM, Kulkarni S, Ghosh SP, Mullaney CP, Condliffe D, Srinivasan V. 2011. Hematopoietic recovery and amelioration of radiation-induced lethality by the vitamin E isoform delta-tocotrienol. Radiat Res. 175(6):736–745.
   PubMed Web of Science ®Google Scholar
• Satyamitra MM, Kumar VP, Biswas S, Cary L, Dickson L, Venkataraman S, Ghosh SP. 2017. Impact of abbreviated filgrastim schedule on survival and hematopoietic recovery after irradiation in four mouse strains with different radiosensitivity. Radiat Res. 187(6):659–671.
   PubMed Web of Science ®Google Scholar
• Schoch A, Thorey IS, Engert J, Winter G, Emrich T. 2014. Comparison of the lateral tail vein and the retro-orbital venous sinus routes of antibody administration in pharmacokinetic studies. Lab Anim. 43(3):95–99.
   Web of Science ®Google Scholar
• Seed TM, Xiao S, Manley N, Nikolich-Zugich J, Pugh J, Van den Brink M, Hirabayashi Y, Yasutomo K, Iwama A, Koyasu S, et al. 2016. An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: observations, problems, solutions and lessons learned. Int J Radiat Biol. 92(2):59–70.
   PubMed Web of Science ®Google Scholar
• Seifter E, Mendecki J, Holtzman S, Kanofsky JD, Friedenthal E, Davis L, Weinzweig J. 1988. Role of vitamin A and beta carotene in radiation protection: relation to antioxidant properties. Pharmacol Ther. 39(1–3):357–365.
   PubMed Web of Science ®Google Scholar
• Shaheen AA, Hassan SM. 1991. Radioprotection of whole-body gamma-irradiation-induced alteration in some haematological parameters by cysteine, vitamin E and their combination in rats. Strahlenther Onkol. 167(8):498–501.
   PubMedGoogle Scholar
• Silasi G, Diaz-Heijtz R, Besplug J, Rodriguez-Juarez R, Titov V, Kolb B, Kovalchuk O. 2004. Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females. Biochem Biophys Res Commun. 325(4):1223–1235.
   PubMed Web of Science ®Google Scholar
• Silver LM. 1995. Mouse genetics: concepts and applications. New York: Oxford University Press.
   Google Scholar
• Singh VK, Beattie LA, Seed TM. 2013. Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures. J Radiat Res. 54(6):973–988.
   PubMed Web of Science ®Google Scholar
• Smith E, Stockwell JD, Schweitzer I, Langley SH, Smith AL. 2004. Evaluation of cage micro-environment of mice housed on various types of bedding materials. Contemp Top Lab Anim Sci. 43(4):12–17.
   PubMedGoogle Scholar
• Sofi MH, Gudi R, Karumuthil-Melethil S, Perez N, Johnson BM, Vasu C. 2014. pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes. 63(2):632–644.
   PubMed Web of Science ®Google Scholar
• Solberg TD, De Salles AA, Hovda D, Holly FE. 1994. A universal, multi-modality localization system for animal radiosurgery. Acta Neurochir Suppl. 62:28–32.
   PubMedGoogle Scholar
• Son H, Lee SM, Yoon RG, Lee H, Lee I, Kim S, Chung WY., Lee JW 2017. Effect of selenium supplementation for protection of salivary glands from iodine-131 radiation damage in patients with differentiated thyroid cancer. Hell J Nucl Med. 20(1):62–70.
   PubMed Web of Science ®Google Scholar
• Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, Wieskopf JS, Acland EL, Dokova A, Kadoura B, et al. 2014. Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nat Methods. 11(6):629–632.
   PubMed Web of Science ®Google Scholar
• Spiegelmann R, Friedman WA, Bova FJ, Theele DP, Mickle JP. 1993. LINAC radiosurgery: an animal model. J Neurosurg. 78(4):638–644.
   PubMed Web of Science ®Google Scholar
• Steel CD, Stephens AL, Hahto SM, Singletary SJ, Ciavarra RP. 2008. Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model. Lab Anim. 37(1):26–32.
   Web of Science ®Google Scholar
• Stojkovic R, Fucic A, Ivankovic D, Jukic Z, Radulovic P, Grah J, Kovacevic N, Barisic L, Kruslin B. 2016. Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation. Arh Hig Rada Toksikol. 67(4):297–303.
   PubMed Web of Science ®Google Scholar
• Storer JB. 1966. Chapter 22, Acute responses to ionizing radiation. In: Green EL, editor. Biology of the Laboratory Mouse. 2nd ed. New York: Dover Publications Inc.
   Google Scholar
• Stricklin D, Prins R, Bellman J. 2018. Development of age-dependent dose modification factors for acute radiation lethality. Int J Radiat Biol. 96(1):1–44.
   Web of Science ®Google Scholar
• Svendsen C, Alexander J, Paulsen JE, Knutsen HK, Hjertholm H, Brantsaeter AL, Husøy T. 2012. The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice. Lab Anim. 46(3):207–214.
   PubMedGoogle Scholar
• Tajima G, Delisle AJ, Hoang K, O’Leary FM, Ikeda K, Hanschen M, Stoecklein VM, Lederer JA. 2013. Immune system phenotyping of radiation and radiation combined injury in outbred mice. Radiat Res. 179(1):101–112.
   PubMed Web of Science ®Google Scholar
• Thrall KD, Love R, Oʼdonnell KC, Farese AM, Manning R, MacVittie TJ. 2015. An interlaboratory validation of the radiation dose response relationship (DRR) for H-ARS in the rhesus macaque. Health Phys. 109(5):502–510.
   PubMed Web of Science ®Google Scholar
• Thrall KD, Mahendra S, Jackson MK, Jackson W, 3rd, Farese AM, MacVittie TJ. 2019. A comparative dose-response relationship between sexes for mortality and morbidity of radiation-induced lung injury in the rhesus macaque. Health Phys. 116(3):354–365.
   PubMed Web of Science ®Google Scholar
• Tinganelli W, Hitrec T, Romani F, Simoniello P, Squarcio F, Stanzani A, Piscitiello E, Marchesano V, Luppi M, Sioli M. 2019. Hibernation and radioprotection: gene expression in the liver and testicle of rats irradiated under synthetic torpor. Int J Mol Sci. 20(2):352.
   Web of Science ®Google Scholar
• Trujillo T, Spalding J, Langham W. 1962. A study of radiation-induced aging: response of irradiated and non-irradiated mice to cold stress. Radiat Res. 16:114–149.
   Web of Science ®Google Scholar
• Turner ND, Braby LA, Ford J, Lupton JR. 2002. Opportunities for nutritional amelioration of radiation-induced cellular damage. Nutrition. 18(10):904–912.
   PubMed Web of Science ®Google Scholar
• Tuttle AH, Philip VM, Chesler EJ, Mogil JS. 2018. Comparing phenotypic variation between inbred and outbred mice. Nat Methods. 15(12):994–996.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Health and Human Services: US Food and Drug Administration (US FDA). 2015. Guidance for industry: Product development under the Animal Rule. [accessed 2017 July 12]. https://www.fda.gov/downloads/drugs/guidances/ucm399217.pdf.
   Google Scholar
• Uma Devi P, Ganasoundari A, Rao BS, Srinivasan KK. 1999. In vivo radioprotection by ocimum flavonoids: survival of mice. Radiat Res. 151(1):74–78.
   PubMed Web of Science ®Google Scholar
• Uma Devi P, Satyamitra MM. 2004. Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. Int J Radiat Biol. 80(9):653–662.
   PubMed Web of Science ®Google Scholar
• van Bekkum DW. 1968. Radiation biology. New York (NY): Academic Press. (The germfree animal in research).
   Google Scholar
• Velioğlu-Oğünç A, Sehirli O, Toklu HZ, Ozyurt H, Mayadağli A, Ekşioğlu-Demiralp E, Erzik C, Cetinel S, Yeğen BC, Sener G. 2009. Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity. Free Radic Res. 43(11):1060–1071.
   PubMed Web of Science ®Google Scholar
• Wang HB, Tranguch S, Xie HR, Hanley G, Das SK, Dey SK. 2005. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. Proc Natl Acad Sci USA. 102(28):9960–9965.
   PubMed Web of Science ®Google Scholar
• Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, et al. 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 140(12):1037–1051.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Landauer MR. 2003. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology. 189(1–2):1–20.
   PubMed Web of Science ®Google Scholar
• Welch D, Harken AD, Randers-Pehrson G, Brenner DJ. 2015. Construction of mouse phantoms from segmented CT scan data for radiation dosimetry studies. Phys Med Biol. 60(9):3589–3598.
   PubMed Web of Science ®Google Scholar
• Welch D, Turner L, Speiser M, Randers-Pehrson G, Brenner DJ. 2017. Scattered dose calculations and measurements in a life-like mouse phantom. Radiat Res. 187(4):433–442.
   PubMedGoogle Scholar
• Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, et al. 2010. Animal models for medical countermeasures to radiation exposure. Radiat Res. 173(4):557–578.
   PubMed Web of Science ®Google Scholar
• Wilson R, Piacsek B. 1962. Dose-response relationships in X-irradiated germfree and conventional mice. Fed Proc. 21:423.
   Google Scholar
• Yardeni T, Eckhaus M, Morris HD, Huizing M, Hoogstraten-Miller S. 2011. Retro-orbital injections in mice. Lab Anim. 40(5):155–160.
   Web of Science ®Google Scholar
• Yoshizumi T, Brady SL, Robbins ME, Bourland JD. 2011. Specific issues in small animal dosimetry and irradiator calibration. Int J Radiat Biol. 87(10):1001–1010.
   PubMed Web of Science ®Google Scholar
• Yuhas JM, Jacobus DP, Crenshaw JW. 1966. Response of the DBA/2J mouse strain to acute ionizing radiation: the biphasic death pattern. Radiat Res. 28(4):804–810.
   PubMed Web of Science ®Google Scholar
• Zangeneh M, Mozdarani H, Mahmoudzadeh A. 2015. Potent radioprotective effects of combined regimens of famotidine and vitamin C against radiation-induced micronuclei in mouse bone marrow erythrocytes. Radiat Environ Biophys. 54(2):175–181.
   PubMed Web of Science ®Google Scholar
• Zetner D, Andersen LPH, Rosenberg J. 2016. Melatonin as protection against radiation injury: a systematic review. Drug Res. 66(6):281–286.
   Web of Science ®Google Scholar
• Zhang L, Sun W, Wang J, Zhang M, Yang S, Tian Y, Vidyasagar S, Peña LA, Zhang K, Cao Y, et al. 2010. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys. 77(1):261–268.
   PubMed Web of Science ®Google Scholar
• Zhang H, Yan H, Zhou X, Wang H, Yang Y, Zhang J, Wang H. 2017. The protective effects of Resveratrol against radiation-induced intestinal injury. BMC Complement Altern Med. 17(1):410.
   PubMedGoogle Scholar