Antioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-Radiation

References

• Abraham SK, Sarma L, Kesavan PC. 1993. Protective effects of chlorogenic acid, curcumin and β-carotene against γ-radiation-induced in vivo chromosomal damage. Mutat Res Lett. 303(3):109–112.
   PubMed Web of Science ®Google Scholar
• Alizadeh E, Orlando TM, Sanche L. 2015. Biomolecular damage induced by ionizing radiation: the direct and indirect effects of low-energy electrons on DNA. Annu Rev Phys Chem. 66:379–398.
   PubMed Web of Science ®Google Scholar
• Anderson RM. 2019. Cytogenetic biomarkers of radiation exposure. Clin Oncol. 31(5):311–318.
   Web of Science ®Google Scholar
• Araújo MCP, da Luz Dias F, Takahashi CS. 1999. Potentiation by turmeric and curcumin of γ-radiation-induced chromosome aberrations in Chinese hamster ovary cells. Teratog Carcinog Mutagen. 19(1):9–18.
   PubMedGoogle Scholar
• Belyakov OV, Prise KM, Trott KR, Michael BD. 1999. Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles. Int J Radiat Biol. 75(8):985–993.
   PubMed Web of Science ®Google Scholar
• Chishti AA, Baumstark-Khan C, Koch K, Kolanus W, Feles S, Konda B, Azhar A, Spitta LF, Henschenmacher B, Diegeler S, et al. 2018. Linear energy transfer modulates radiation-induced NF-kappa B activation and expression of its downstream target genes. Radiat Res. 189(4):354–370.
   PubMed Web of Science ®Google Scholar
• Cho JW, Park K, Kweon GR, Jang BC, Baek WK, Suh MH, Kim CW, Lee KS, Suh SI. 2005. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp Mol Med. 37(3):186–192.
   PubMed Web of Science ®Google Scholar
• Dizdaroglu M, Jaruga P. 2012. Mechanisms of free radical-induced damage to DNA. Free Radic Res. 46(4):382–419.
   PubMed Web of Science ®Google Scholar
• El-Benhawy SA, Sadek NA, Behery AK, Issa NM, Ali OK. 2016. Chromosomal aberrations and oxidative DNA adduct 8-hydroxy-2-deoxyguanosine as biomarkers of radiotoxicity in radiation workers. J Radiat Res Appl Sci. 9(3):249–258.
   Web of Science ®Google Scholar
• El-Zein RA, Etzel CJ, Munden RF. 2018. The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants. Transl Lung Cancer Res. 7(3):336–346.
   PubMed Web of Science ®Google Scholar
• Farhadi M, Bakhshandeh M, Shafiei B, Mahmoudzadeh A, Hosseinimehr SJ. 2018. The radioprotective effects of nano-curcumin against genotoxicity induced by iodine-131 in patients with differentiated thyroid carcinoma (DTC) by micronucleus assay. Int J Cancer Manag. 11(6):e14193.
   Web of Science ®Google Scholar
• Fearn T, Thompson M. 2001. A new test for “sufficient homogeneity”. Analyst. 126(8):1414–1417.
   PubMed Web of Science ®Google Scholar
• Gao Y, Wang P, Wang Z, Han L, Li J, Tian C, Zhao F, Wang J, Zhao F, Zhang Q, et al. 2019. Serum 8-Hydroxy-2′-Deoxyguanosine level as a potential biomarker of oxidative DNA damage induced by ionizing radiation in human peripheral blood. Dose Response. 17(1):1559325818820649.
   Web of Science ®Google Scholar
• Gaziev AI, Sologub GR, Fomenko LA, Zaichkina SI, Kosyakova NI, Bradbury RJ. 1996. Effect of vitamin-antioxidant micronutrients on the frequency of spontaneous and in vitro gamma-ray-induced micronuclei in lymphocytes of donors: the age factor. Carcinogenesis. 17(3):493–499.
   PubMed Web of Science ®Google Scholar
• Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 126(1):131–138.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Gutteridge JMC, Aruoma OI. 1987. The deoxyribose method: a simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 165(1):215–219.
   PubMed Web of Science ®Google Scholar
• Huber R, Schraube H, Nahrstedt U, Braselmann H, Bauchinger M. 1994. Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations. Mutat Res – Fundam Mol Mech Mutagen. 306(2):135–141.
   PubMed Web of Science ®Google Scholar
• Inano H, Onoda M. 2002. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2′-deoxyguanosine, tumorigenesis, but not mortality, induced by γ-ray irradiation. Int J Radiat Oncol Biol Phys. 53(3):735–743.
   PubMed Web of Science ®Google Scholar
• Jagetia G, Rajanikant G. 2017. Topical application of curcumin augments healing of deep dermal excision wound of mice exposed to whole-body gamma radiation. J Nurs Healthc. 2(1):1–7.
   Google Scholar
• Jagetia G, Venkatesha VA, Reddy T. 2003. Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. Mutagenesis. 18(4):337–343.
   PubMed Web of Science ®Google Scholar
• Jagetia GC. 2007a. Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr. 40(2):74–81.
   PubMed Web of Science ®Google Scholar
• Jagetia GC. 2007b. Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol. 595:301–320.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Aggarwal BB. 2007. “Spicing up” of the immune system by curcumin. J Clin Immunol. 27(1):19–35.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Jacob PS, Rao MNA. 1994. (E)4-[4-N,N-dimethylaminophenyl] but-3-en-2-one (DMAP) treatment inhibits the radiation induced micronucleus formation in bone marrow of BALB/c mice. Mutat Res. 306(1):71–80.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Jayakrishnan A, Fernandes D, Vidyasagar MS. 2001. Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment. Mutat Res – Genet Toxicol Environ Mutagen. 491(1–2):9–16.
   Web of Science ®Google Scholar
• Jagetia GC, Rajanikant GK. 2004a. Effect of curcumin on radiation-impaired healing of excisional wounds in mice. J Wound Care. 13(3):107–109.
   PubMedGoogle Scholar
• Jagetia GC, Rajanikant GK. 2004b. Role of curcumin, a naturally occurring phenolic compound of turmeric in accelerating the repair of excision wound, in mice whole-body exposed to various doses of gamma-radiation. J Surg Res. 120(1):127–138.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Rajanikant GK. 2005. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemi-body γ-irradiation. Plast Reconstr Surg. 115(2):515–528.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Rajanikant GK. 2015. Curcumin stimulates the antioxidant mechanisms in mouse skin exposed to fractionated γ-irradiation. Antioxidants. 4(1):25–41.
   Web of Science ®Google Scholar
• Jagetia GC, Reddy TK. 2002. The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. Mutat Res – Genet Toxicol Environ Mutagen. 519(1–2):37–48.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Venkatesh P, Baliga MS. 2003. Evaluation of the radioprotective effect of Aegle marmelos (L.) Correa in cultured human peripheral blood lymphocytes exposed to different doses of gamma-radiation: a micronucleus study. Mutagenesis. 18(4):387–393.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Venkatesha VA. 2005. Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes. Environ Mol Mutagen. 46(1):12–21.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Venkatesha VA. 2006. Mangiferin protects human peripheral blood lymphocytes against γ-radiation-induced DNA strand breaks: a fluorescence analysis of DNA unwinding assay. Nutr Res. 26(6):303–311.
   Web of Science ®Google Scholar
• Khopde SM, Priyadarsini KI, Guha SN, Satav JG, Venkatesan P, Rao MNA. 2000. Inhibition of radiation-induced lipid peroxidation by tetrahydrocurcumin: possible mechanisms by pulse radiolysis. Biosci Biotechnol Biochem. 64(3):503–509.
   PubMed Web of Science ®Google Scholar
• Kirsch-Volders M, Sofuni T, Aardema M, Albertini S, Eastmond D, Fenech M, Ishidate M, Kirchner S, Lorge E, Morita T, et al. 2003. Report from the in vitro micronucleus assay working group. Mutat Res – Genet Toxicol Environ Mutagen. 540(2):153–163.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. 2017. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 174(11):1325–1348.
   PubMed Web of Science ®Google Scholar
• Landuzzi F, Palla PL, Cleri F. 2017. Stability of radiation-damaged DNA after multiple strand breaks. Phys Chem Chem Phys. 19(22):14641–14651.
   PubMed Web of Science ®Google Scholar
• Lao CD, Ruffin IM, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE. 2006. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 6:10.
   PubMedGoogle Scholar
• Leung AY. 1980. Encyclopedia of common natural ingredients used in food, drugs, and cosmetics. New York (NY): John Wiley.
   Google Scholar
• Majer BJ, Laky B, Knasmüller S, Kassie F. 2001. Use of the micronucleus assay with exfoliated epithelial cells as a biomarker for monitoring individuals at elevated risk of genetic damage and in chemoprevention trials. Mutat Res – Rev Mutat Res. 489(2–3):147–172.
   Web of Science ®Google Scholar
• Meng A, Yu T, Chen G, Brown SA, Wang Y, Thompson JS, Zhou D. 2003. Cellular origin of ionizing radiation-induced NF-kappaB activation in vivo and role of NF-kappaB in ionizing radiation-induced lymphocyte apoptosis. Int J Radiat Biol. 79(11):849–861.
   PubMed Web of Science ®Google Scholar
• Mensor LL, Menezes FS, Leitão GG, Reis AS, dos Santos TC, Coube CS, Leitão SG. 2001. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother Res. 15(2):127–130.
   PubMed Web of Science ®Google Scholar
• Miller NJ, Castelluccio C, Tijburg L, Rice-Evans C. 1996. The antioxidant properties of theaflavins and their gallate esters-radical scavengers or metal chelators? FEBS Lett. 392(1):40–44.
   PubMed Web of Science ®Google Scholar
• Mitra AK, Krishna M. 2004. In vivo modulation of signaling factors involved in cell survival. J Radiat Res. 45(4):491–495.
   PubMed Web of Science ®Google Scholar
• Nagata N, Sugahara S, Tanaka T. 1972. Radiation protection by 2-mercaptopropionylglycine in Mice. J Radiat Res. 13(3):163–166.
   PubMedGoogle Scholar
• Nakano T, Xu X, Salem AMH, Shoulkamy MI, Ide H. 2017. Radiation-induced DNA-protein cross-links: mechanisms and biological significance. Free Radic Biol Med. 107:136–145.
   PubMed Web of Science ®Google Scholar
• Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. 2017. The essential medicinal chemistry of curcumin. J Med Chem. 60(5):1620–1637.
   PubMed Web of Science ®Google Scholar
• Nguyen MH, Pham ND, Dong B, Nguyen TH, Bui CB, Hadinoto K. 2017. Radioprotective activity of curcumin-encapsulated liposomes against genotoxicity caused by Gamma Cobalt-60 irradiation in human blood cells. Int J Radiat Biol. 93(11):1267–1273.
   PubMed Web of Science ®Google Scholar
• Reddig A, Rübe CE, Rödiger S, Schierack P, Reinhold D, Roggenbuck D. 2018. DNA damage assessment and potential applications in laboratory diagnostics and precision medicine. J Lab Precis Med. 3:31–31.
   Google Scholar
• Sage E, Shikazono N. 2017. Radiation-induced clustered DNA lesions: repair and mutagenesis. Free Radic Biol Med. 107:125–135.
   PubMed Web of Science ®Google Scholar
• Shafaghati N, Hedayati M, Hosseinimehr SJ. 2014. Protective effects of curcumin against genotoxicity induced by 131-iodine in human cultured lymphocyte cells. Pharmacogn Mag. 10(38):106–110.
   PubMed Web of Science ®Google Scholar
• Shimura N, Kojima S. 2018. The lowest radiation dose having molecular changes in the living body. Dose Response. 16(2):1559325818777326.
   Web of Science ®Google Scholar
• Siama Z, Zosangzuali M, Vanlalruati A, Jagetia GC, Pau KS, Kumar NS. 2019. Chronic low dose exposure of hospital workers to ionizing radiation leads to increased micronuclei frequency and reduced antioxidants in their peripheral blood lymphocytes. Int J Radiat Biol. 95(6):697–709.
   PubMed Web of Science ®Google Scholar
• Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J. 2003. Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med. 12(1):17–24.
   PubMed Web of Science ®Google Scholar
• Soltani B, Bodaghabadi N, Mahpour G, Ghaemi N, Sadeghizadeh M. 2016. Nanoformulation of curcumin protects HUVEC endothelial cells against ionizing radiation and suppresses their adhesion to monocytes: potential in prevention of radiation-induced atherosclerosis. Biotechnol Lett. 38(12):2081–2088.
   PubMed Web of Science ®Google Scholar
• Sommer S, Buraczewska I, Kruszewski M. 2020. Micronucleus assay: the state of art, and future directions. Int J Mol Sci. 21(4):1534.
   PubMed Web of Science ®Google Scholar
• Sreejayan N, Rao M. 1996. Free radical scavenging activity of curcuminoids. Arzneimittelforschung. 46(2):169–171.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, Prasad R, Menon VP. 2006. Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutat Res. 611(1–2):96–103.
   PubMed Web of Science ®Google Scholar
• Sweeney T. 1979. A survey of compounds from the antiirradiation drug development program of the U.S. Washington, DC: Army Medical Research and Development Command, Government Printing Office.
   Google Scholar
• Tessner TG, Muhale F, Schloemann S, Cohn SM, Morrison AR, Stenson WF. 2004. Ionizing radiation up-regulates cyclooxygenase-2 in I407 cells through p38 mitogen-activated protein kinase. Carcinogenesis. 25(1):37–45.
   PubMed Web of Science ®Google Scholar
• Thresiamma K, George J, Kuttan R. 1998. Protective effect of curcumin, ellagic acid and bixin on radiation induced genotoxicity. J Exp Clin Cancer Res. 17(4): 431–434.
   PubMed Web of Science ®Google Scholar
• Umegaki K, Ikegami S, Inoue K, Ichikawa T, Kobayashi S, Soeno N, Tomabechi K. 1994. Beta-carotene prevents x-ray induction of micronuclei in human lymphocytes. Am J Clin Nutr. 59(2):409–412.
   PubMed Web of Science ®Google Scholar
• Vrinda B, Devi PU. 2001. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat Res – Genet Toxicol Environ Mutagen. 498(1–2):39–46.
   PubMed Web of Science ®Google Scholar
• Wallace SS. 1994. DNA damages processed by base excision repair: biological consequences. Int J Radiat Biol. 66(5):579–589.
   PubMed Web of Science ®Google Scholar
• Yamamoto KI, Yasumoto K. 1980. A comparison of diameters of micronuclei induced by clastogens and by spindle poisons. Mutat Res – Fundam Mol Mech Mutagen. 71(1):127–131.
   PubMed Web of Science ®Google Scholar
• Ye CJ, Sharpe Z, Alemara S, Mackenzie S, Liu G, Abdallah B, Horne S, Regan S, Heng HH. 2019. Micronuclei and genome chaos: changing the system inheritance. Genes. 10(5):366.
   PubMed Web of Science ®Google Scholar
• Yim JH, Yun JM, Kim JY, Nam SY, Kim CS. 2017. Estimation of low-dose radiation-responsive proteins in the absence of genomic instability in normal human fibroblast cells. Int J Radiat Biol. 93(11):1197–1206.
   PubMed Web of Science ®Google Scholar
• Zhu HF, Yan PW, Wang LJ, Liu YT, Wen J, Zhang Q, Fan YX, Luo YH. 2018. Protective properties of Huperzine A through activation Nrf2/ARE-mediated transcriptional response in X-rays radiation-induced NIH3T3 cells. J Cell Biochem. 119(10):8359–8367.
   PubMed Web of Science ®Google Scholar