Hepatotoxicity and renal toxicity induced by radiation and the protective effect of quercetin in male albino rats

References

• Ali S, Khan MR, Shah SA, Batool R, Maryam S, Majid M, Zahra Z. 2018. Protective aptitude of periploca hydaspidis falc against CCl4 induced hepatotoxicity in experimental rats. Biomed Pharmacother. 105:1117–1132.
   PubMed Web of Science ®Google Scholar
• Bacanlı M, Aydın S, Taner G, Göktaş HG, Şahin T, Başaran AA, Başaran N. 2016. Does rosmarinic acid treatment have protective role against sepsis-induced oxidative damage in Wistar Albino rats? Hum Exp Toxicol. 35(8):877–886.
   PubMed Web of Science ®Google Scholar
• Bakheet SA. Assessment of anti-cytogenotoxic effects of quercetin in animals treated with topotecan. Oxid Med Cell Longev. 2011;2011:824597.
   Google Scholar
• Bakkal BH, Gultekin FA, Guven B, Turkcu UO, Bektas S, Can M. 2013. Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats. Braz J Med Biol Res. 46(9):789–796.
   PubMed Web of Science ®Google Scholar
• Batool R, Khan MR, Sajid M, Ali S, Zahra Z. 2019. Estimation of phytochemical constituents and in vitro antioxidant potencies of Brachychiton populneus (Schott & Endl.) R.Br.). BMC Chem. 13(1):32.
   PubMedGoogle Scholar
• Borrego-Soto G, Ortiz-López R, Rojas-Martínez A. 2015. Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Genet Mol Biol. 38(4):420–432.
   PubMed Web of Science ®Google Scholar
• Cai X, Fang Z, Dou J, Yu A, Zhai G. 2013. Bioavailability of quercetin: problems and promises. Curr Med Chem. 20(20):2572–2582.
   PubMed Web of Science ®Google Scholar
• Cevik Ö, Çadırcı S, Şener TE, Tinay I, Akbal C, Tavukçu HH, Çetinel S, Kıran D, Şener G. 2013. Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum tissue: a role on apoptosis and oxidative stress. Free Radic Res. 47(9):683–691.
   PubMed Web of Science ®Google Scholar
• Cohen EP, Robbins MEC. 2003. Radiation nefropathy. Semin, Nephrol. 23(5):486–499.
   PubMed Web of Science ®Google Scholar
• Das U, Manna K, Sinha M, Datta S, Das DK, Chakraborty A, Ghosh M, Saha KD, Dey S. 2014. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLOS One. 9(5):e97599.
   PubMed Web of Science ®Google Scholar
• Di Maggio FM, Minafra L, Forte GI, Cammarata FP, Lio D, Messa C, Gilardi MC, Bravata V. 2015. Portrait of inflammatory response to ionizing radiation treatment. J Inflamm. 12:14.
   Google Scholar
• Dobrikova AG, Apostolova EL. 2015. Damage and protection of the photosynthetic apparatus from UV-B radiation. II. Effect of quercetin at different pH. J Plant Physiol. 184:98–105.
   PubMed Web of Science ®Google Scholar
• Emami B, Lyman J, Brown A, Coia L, Goitein M, Munzenrider JE, Shank B, Solin LJ, Wesson M. 1991. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys. 21(1):109–122.
   PubMed Web of Science ®Google Scholar
• Eroglu C, Yildiz OG, Saraymen R, Soyuer S, Kilic E, Ozcan S. 2008. Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats. CIM. 31(4):182–188.
   Google Scholar
• Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Salehi E, Nashtaei MS, Shabeeb D, Musa AE, Fallah H, Najafi M. 2019. Intercellular communications-redox interactions in radiation toxicity; potential targets for radiation mitigation. J Cell Commun Signal. 13(1):3–16.
   PubMed Web of Science ®Google Scholar
• Fatokun AA, Tome M, Smith RA, Darlington LG, Stone TW. 2015. Protection by the flavonoids quercetin and luteolin against peroxide- or menadione-induced oxidative stress in MC3T3-E1 osteoblast cells. Nat Prod Res. 29(12):1127–1132.
   PubMed Web of Science ®Google Scholar
• Feinendegen LE. 2002. Reactive oxygen species in cell responses to toxic agents. Hum Exp Toxicol. 21(2):85–90.
   PubMed Web of Science ®Google Scholar
• Fuchs-Tarlovsky V. 2013. Role of antioxidants in cancer therapy. Nutrition. 29(1):15–21.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Chirico S. 1993. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr. 57(5 Suppl):715S–725S.
   PubMed Web of Science ®Google Scholar
• Harrison L. 2013. Radiation induced DNA damage, repair and therapeutics. In: Madhusudan S, Wilson DM III (eds) DNA repair and cancer: from bench to clinic. Boca Raton: CRC Press; p. 92–136.
   Google Scholar
• Hassan SS, Razzaque A, Ahmad Z, Pazdernik V, Amin SN. 2018. Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats? Can J Physiol Pharmacol. 96(1):51–59.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Rizk A, Thomann C, Motawie A, Abdelfattah S, Ahmad Z. 2019. Preconditioning with atorvastatin against renal ischemia-reperfusion injury in nondiabetic versus diabetic rats. Can J Physiol Pharmacol. 97(1):1–14.
   PubMed Web of Science ®Google Scholar
• Hassan SS, Thomann C, Ettarh R, Ahmad Z. 2017. Possible protective role of silybin against polymyxin E-induced toxic effect in rat kidneys: a biochemical approach. Neurourol Urodyn. 36(8):2003–2010.
   PubMed Web of Science ®Google Scholar
• Havasi A, Borkan SC. 2011. Apoptosis and acute kidney injury. Kidney Int. 80(1):29–40.
   PubMed Web of Science ®Google Scholar
• Hu J, Yu Q, Zhao F, Ji J, Jiang Z, Chen X, Gao P, Ren Y, Shao S, Zhang L, et al. 2015. Protection of quercetin against triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells. Chem Biol Interact. 240:38–46.
   PubMed Web of Science ®Google Scholar
• Jagetia GC. 2007. Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr. 40(2):74–81.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, Reddy TK. 2005. Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. Life Sci. 77(7):780–794.
   PubMed Web of Science ®Google Scholar
• Ji LL, Sheng YC, Zheng ZY, Shi L, Wang ZT. 2015. The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. Free Radic Biol Med. 85:12–23.
   PubMed Web of Science ®Google Scholar
• Kale A, Piskin Ö, Bas Y, Aydin BG, Can M, Elmas Ö, Büyükuysal Ç. 2018. Neuroprotective effects of Quercetin on radiation-induced brain injury in rats. J Radiat Res. 59(4):404–410.
   PubMed Web of Science ®Google Scholar
• Kalpana KB, Devipriya N, Srinivasan M, Menon VP. 2009. Investigation of the radioprotective efficacy of hesperidin against gamma-radiation induced cellular damage in cultured human peripheral blood lymphocytes. Mutat Res. 676(1–2):54–61.
   PubMed Web of Science ®Google Scholar
• Khozouz RF, Huq SZ, Perry MC. 2008. Radiation-induced liver disease. J Clin Oncol. 26(29):4844–4845.
   PubMed Web of Science ®Google Scholar
• Kim J, Jung Y. 2017. Radiation-induced liver disease: current understanding and future perspectives. Exp Mol Med. 49(7):e359.
   PubMedGoogle Scholar
• Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, et al. 2014. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 21(5):836–844.
   PubMed Web of Science ®Google Scholar
• Liu CM, Zheng YL, Lu J, Zhang ZF, Fan SH, Wu DM, Ma JO. 2010. Quercetin protects rat liver against lead-induced oxidative stress and apoptosis. Environ Toxicol Pharmacol. 29(2):158–166.
   PubMed Web of Science ®Google Scholar
• Marini P, Budach W, Niyazi M, Junginger D, Stickl S, Jendrossek V, Belka C. 2009. Combination of the pro-apoptotic TRAIL-receptor antibody mapatumumab with ionizing radiation strongly increases long-term tumor control under ambient and hypoxic conditions. Int J Radiat Oncol Biol Phys. 75(1):198–202.
   PubMed Web of Science ®Google Scholar
• Medhora M, Gao F, Wu Q, Molthen RC, Jacobs ER, Moulder JE, Fish BL. 2014. Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs. Radiat Res. 182(5):545–555.
   PubMed Web of Science ®Google Scholar
• Mohamed AKA, Sherif AAM. 2013. The biochemical changes in rats' blood serum levels exposed to different gamma radiation doses. Afr J Pharm Pharmacol. 7(15):785–792.
   Google Scholar
• Morales AI, Vicente-Sanchez C, Sandoval JMS, Egido J, Mayoral P, Arevalo MA, Fernandez-Tagarro M, Lopez-Novoa JM, Perez-Barriocanal F. 2006. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol. 44(12):2092–2100.
   PubMed Web of Science ®Google Scholar
• Okunie P, Chen Y, Maguire DJ, Huser AK. 2008. Molecular markers of radiation-related normal tissue toxicity. Cancer Metastasis Rev. 27(3):363–374.
   PubMed Web of Science ®Google Scholar
• Onder GO, Balcioglu E, Baran M, Ceyhan A, Cengiz O, Alisan Suna P, Yıldız OG, Yay A. 2021. The different doses of radiation therapy-induced damage to the ovarian environment in rats. Int J Radiat Biol. 97(3):367–375.
   PubMed Web of Science ®Google Scholar
• Oz Gergin O, Bayram A, Gergin IS, Aksu R, Yay A, Balcıoglu E, Polat S, Coşkun G, Soyer Sarıca Z, Yıldız K. 2019. Comparison of myotoxic effects of levobupivacaine, bupivacaine and ropivacaine: apoptotic activity and acute effect on pro-inflammatory cytokines. Biotech Histochem. 94(4):252–260.
   PubMed Web of Science ®Google Scholar
• Patil SL, Rao NB, Somashekarappa HM, Rajashekhar KP. 2014. Antigenotoxic potential of rutin and quercetin in swiss mice exposed to gamma radiation. Biomed J. 37(5):305–313.
   PubMedGoogle Scholar
• Prabu SM, Muthumani M, Shagirtha K. 2013. Quercetin potentially attenuates cadmium induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats. Eur Rev Med Pharmacol Sci. 17(5):582–595.
   PubMed Web of Science ®Google Scholar
• Prasad NR, Menon VP, Vasudev V, Pugalendi KV. 2005. Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes. Toxicology. 209(3):225–235.
   PubMed Web of Science ®Google Scholar
• Rahmouni F, Badraoui R, Amri N, Elleuch A, El-Feki A, Rebai T, Saoudi M. 2019. Hepatotoxicity and nephrotoxicity in rats induced by carbon tetrachloride and the protective effects of Teucrium polium and vitamin C. Toxicol Mech Methods. 29 (5):313–321.
   PubMed Web of Science ®Google Scholar
• Robbins ME, Zhao W, Davis CS, Toyokuni S, Bonsib SM. 2002. Radiation-induced kidney injury: a role for chronic oxidative stress? Micron. 33(2):133–141.
   PubMed Web of Science ®Google Scholar
• Huang R, Zhou P-K. 2020. HIF-1 signaling: A key orchestrator of cancer radioresistance. Radiol Med Prot. 1(1):7–14.
   Google Scholar
• Safhi MM. 2018. Nephroprotective effect of Zingerone against CCl4-induced renal toxicity in Swiss albino mice: molecular mechanism. Oxid Med Cell Longev. 2018:2474831.
   PubMed Web of Science ®Google Scholar
• Salem AM, Mohammaden TF, Ali MAM, Mohamed EA, Hasan HF. 2016. Ellagic and ferulic acids alleviate gamma radiation and aluminium chloride-induced oxidative damage. Life Sci. 160:2–11.
   PubMed Web of Science ®Google Scholar
• Sarıozkan S, Canturk F, Yay A, Akçay A. 2012. The effect of different storage temperature on sperm parameters and DNA damage in liquid stored New Zealand rabbit spermatozoa. Kafkas Univ Vet Fak Derg. 18(3):475–480.
   Web of Science ®Google Scholar
• Schaue D, McBride WH. 2015. Opportunities and challenges of radiotherapy for treating cancer. Nat Rev Clin Oncol. 12(9):527–540.
   PubMed Web of Science ®Google Scholar
• Shedid SM, Abdel-Magied N, Saada HN. 2019. Role of betaine in liver injury induced by the exposure to ionizing radiation. Environ Toxicol. 34(2):123–130.
   PubMed Web of Science ®Google Scholar
• Shin HS, Yang WJ, Choi EM. 2013. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. J Trace Elem Med Biol. 27(2):154–159.
   PubMed Web of Science ®Google Scholar
• Shinomiya N. 2001. New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'. J Cell Mol Med. 5(3):240–253.
   PubMed Web of Science ®Google Scholar
• Shirazi A, Mihandoost E, Ghobadi G, Mohseni M, Ghazi-Khansari M. 2013. Evaluation of radio-protective effect of melatonin on whole body irradiation induced liver tissue damage. Cell J. 14(4):292–297.
   PubMed Web of Science ®Google Scholar
• Srinivasan M, A. Sudheer AR, Rajasekaran KN, Menon VP. 2008. Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro. Chem Biol Interact. 176(1):1–8.
   PubMed Web of Science ®Google Scholar
• Storniolo A, Raciti M, Cucina A, Bizzarri M, Di Renzo L. 2015. Quercetin affects Hsp70/IRE1α mediated protection from death induced by endoplasmic reticulum stress. Oxid Med Cell Longev. 2015:645157.
   PubMed Web of Science ®Google Scholar
• Taylor RC, Cullen SP, Martin SJ. 2008. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 9(3):231–241.
   PubMed Web of Science ®Google Scholar
• Trosic I, Pavicic I, Milkovic-Kraus S, Mladinic M, Zeljezic D. 2011. Effect of electromagnetic radiofrequency radiation on the rats’ brain, liver and kidney cells measured by comet assay. Coll Antropol. 35(4):1259–1264.
   PubMedGoogle Scholar
• Wild CP, Espina C, Bauld L, Bonanni B, Brenner H, Brown K, Dillner J, Forman D, Kampman E, Nilbert M, et al. 2019. Cancer prevention Europe. Mol Oncol. 13(3):528–534.
   PubMed Web of Science ®Google Scholar
• Xie LH, Zhang XH, Hu XD, Min XY, Zhou QF, Zhang HQ. 2016. Mechanisms of an increased level of serum iron in gamma-irradiated mice. Radiat Environ Biophys. 55(1):81–88.
   PubMed Web of Science ®Google Scholar
• Yahyapour R, Motevaseli E, Rezaeyan A, Abdollahi H, Farhood B, Cheki M, Rezapoor S, Shabeeb D, Musa AE, Najafi M, et al. 2018. Reduction-oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics. Clin Transl Oncol. 20(8):975–988.
   PubMed Web of Science ®Google Scholar
• Yahyapour R, Salajegheh A, Safari A, Amini P, Rezaeyan A, Amraee A, Najafi M. 2018. Radiation-induced non-targeted effect and carcinogenesis; implications in clinical radiotherapy. J Biomed Phys Eng. 8(4):435–446.
   PubMedGoogle Scholar
• Yang L, Yang J, Li G, Li Y, Wu R, Cheng J, Tang Y. 2017. Pathophysiological responses in rat and mouse models of radiation-induced brain injury. Mol Neurobiol. 54(2):1022–1032.
   PubMed Web of Science ®Google Scholar