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Research Article

Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens

Pages 673-680 | Published online: 03 Jul 2009

  • ALFER, T., MOTHERSILL, C. and SEYMOUR, C. B., 1988, Lethal mutations attributable to misrepair of Q1esions. International Journal of Radiation Biology, 54, 525-530.
  • BORN, R. and TROTT, K. R., 1988, Clonogenicity of the progeny of surviving cells after irradiation., International Journal of Radiation Biology, 53, 319-330.
  • BOUKAMP, P., STANBRIDGE, E. J., Foo, D. Y., CERUTTI, P. A., and FUSENIG, N. E., 1990, C-Ha-ras oncogene expression in immortalised human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy., Cancer Research, 50, 2840-2847.
  • BRANCH, P., AQUILINA, G., BIGNIMI, M. and KARRAN, P., 1993, Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage., Nature, 362, 652-654.
  • CARON, R. M., NAGASAWA, H, Yu, Y, PFENNING, T., VETROVS, H. and LITTLE, J. B., 1997, Evidence for a role for genomic instability in radiation-induced mutagenesis., Radiation Oncology Investigations, 5, 119-123.
  • CHANG, W. P. and LITTLE, J. B., 1992, Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation., Carcinogenesis, 13, 923-928.
  • CLUTTON, S. M., TOWNSEND, K. M. S, WALKER, C, ANSELL, J. D. and WRIGHT, E. G., 1996, Radiation-induced genomic instability and persisting oxidative stress in primary bone marrow cultures., Carcinogenesis, 17, 1633-1639.
  • COLUCCI, S., MOTHERSILL, C., HARNEY, J., GAMBLE, C., SEYMOUR, C. B. and ARRAND, J. E., 1997, Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to lowdose gamma radiation., International Journal of Radiation Biology, 72, 21-31.
  • DESHPLANDE, A., GOODWIN, E. H., BAILEY, S. M., MARRONE, B. L. and LEHNERT, B. E., Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extranuclear target., Radiation Research, 145, 260-267.
  • FRANK, J. P. and WILLIAMS, J. R., 1982, X-ray induction of persistent hypersensitivity to mutation., Science, 216, 307308.
  • GORGOJO, L. and LITTLE, J. B., 1989, Expression of lethal mutations in the progeny of irradiated mammalian cells., International Journal of Radiation Biology, 55, 619-630.
  • HALL, E. J., 1994, Radiobiology for the Radiobiologist, 4th edition (New York and Philadelphia: Lippincott).
  • HAUFTMANN, N. and CADENAS, E., 1997, The oxygen paradox: biochemistry of active oxygen. In Oxidative Stress and the Molecular Biology of Antioxidant Defenses, edited by J. G. Scandalios (Cold Spring Harbour Laboratory Press), pp. 1-20.
  • KADHIM, M. A., LORIMORE, S. A., TOWNSEND, K. M. S., GOODHEAD, D. T., BUCKLE, V. J. and WRIGHT, E. G., 1995, Radiation-induced genomic instability: delayed cytogenetic aberrations and apoptosis in primary human bone marrow cells., International Journal of Radiation Biology, 57, 287-293.
  • KADHIM, M., MACDONALD, D. A., GOODHEAD, S. A., LORIMORE, S. A, MARSDEN, S. J. and WRIGHT, E. G., 1992, Tramsmission of chromosomal instability after plutonium alpha-particle irradiation., Nature, 355, 738-740.
  • KADHIM, M. A., WALKER, C. A., PLUMB, M. A. and WRIGHT, E. G., 1996, No association between p53 status and alpha-particle-induced chromosomal instability in human lymphoblastoid cells., International Journal of Radiation Biology, 69, 167-174.
  • KROEMER, G., 1997, The proto-oncogene bcl-2 and its role in regulating apoptosis., Nature Medicine, 3, 614-620.
  • LIMOLI, C. L., KAPLAN, M. I., PHILIPS, J. W., ADAIR, G. M., and MORGAN, W. F., 1997, Differential induction of chromosomal instability by DNA strand breaking agents., Cancer Research, 57, 4048-4056.
  • LOEB, L. A., 1991, Mutator phenotype may be required for multistage carcinogenesis., Cancer Research, 51, 3075-3079.
  • MANTI, L., JAMALI, M., PRISE, K. M., MICHAEL, B. and TROTT, K.-R., 1997, Genomic instability in Chinese hamster cells after exposure to X-rays or alpha particles of different mean linear energy transfer., Radiation Research, 147, 22-28.
  • MENDONCA, M. S., ANTONIO, R. J. and REDPATH, J. L., 1993, Delayed heritable damage and epigenetics in radiationinduced neoplastic transformation of human hybrid cells., Radiation Research, 134, 209-216.
  • MORGAN, W. F, DAY, J. P., KAPLAN, M. I., MCGHEE, E. M. and LIMOLI, C. L., 1996, Genomic instability induced by ionising radiation., Radiation Research, 146, 247-258.
  • MOTHERSILL, C, HARNEY, J, LYNG, F, COTTELL, D. and SEYMOUR, C. B., 1995, Primary expiants of normal human uroepithelium show an unusual response to low doses of Cobalt 60 gamma rays., Radiation Research, 142, 181-187.
  • MOTHERSILL, C. and SEYMOUR, C. B., 1997a, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells: possible evidence of a 'Bystander Effect'., International Journal of Radiation Biology, 71, 421-427.
  • MOTHERSILL, C. and SEYMOUR, C. B., 1997b, Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells., International Journal of Radiation Biology, 72, 597-606.
  • NAGAZAWA, H. and LITTLE, J. B., 1992, Induction of sisterchromatid exchanges by extremely low doses of alpha particles., Cancer Research, 52, 6394-6396.
  • O'REILLY, J. and MOTHERSILL, C., 1997, Delayed cell death following exposure of human and fish cells to UVA and UVB., International Journal of Radiation Biology, 72, 111-119.
  • O'REILLY, S, MOTHERSILL, C. and SEYMOUR, C. B., 1994, Lethal mutations occur at a constant rate in human keratinocytes following carcinogen treatment., International Journal of Radiation Biology, 76, 134-142.
  • PAQUETTE, B. and LITTLE, J. B., 1994, In vivo enhancement of genomic instability in minisatellite sequences of mouse C3H 10T1/2 cells transformed in vitro by X-rays., Cancer Research, 54, 3173-3178.
  • PUCK, T. T. and MARCUS, P. I., 1956, Action of X-rays on mammalian cells., Journal of Experimental Medicine, 103, 653-666.
  • RICHTER, C. and SCHWEIZER, M., 1997, Oxidative stress in mitochondria. In Oxidative Stress and the Molecular Biology of Antioxidant Definses, edited byJ. G. Scandalios (Cold Spring Harbour Laboratory Press), pp. 169-200.
  • SENTMAN,C. L., SHUTTER, J. R., HOCKENBERRY, D., KANAGAWA, O. and KORYSMEYER, S. J., 1991, Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes., Cell, 67, 879-888.
  • SEYMOUR, C. B, MOTHERSILL, C. and ALPER, T., 1986, High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation., International Journal of Radiation Biology, 50, 167-169.
  • SEYMOUR, C. B. and MOTHERSILL, C., 1992, All colonies of CHO cells surviving gamma radiation contain abnormal cells., Mutation Research, 267, 19-30.
  • ZAMZAMI, N., MARCHETTI, P., CASTEDO, M., HIRSCH, T., SUSIN, S., MASSE, B. and KROEMER, G., 1996, Inhibitors of permeability transition interfere with the disruption of mitochondrial transmembrane potential during apoptosis., FEBS Letters, 384, 53-57.

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