156
Views
4
CrossRef citations to date
0
Altmetric
Papers

Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-α converting enzyme, calpain and kinases

, , , , , , & show all
Pages 89-98 | Published online: 13 Aug 2009

References

  • Amour A, Slocombe PM, Webster A, Butler M, Knight CG, Smith BJ, Stephens PE, Shelley C, Hutton M, Knauper V, Docherty AJ, Murphy G. TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett 1998; 435(1)39–44
  • Blacker M, Noe MC, Carty TJ, Goodyer CG, LeBlanc AC. Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons. J Neurochem 2002; 83(6)1349–1357
  • Borsch-Haubold AG, Pasquet S, Watson SP. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase. J Biol Chem 1998; 273(44)28766–28772
  • Bromme D, Bonneau PR, Lachance P, Wiederanders B, Kirschke H, Peters C, Thomas DY, Storer AC, Vernet T. Functional expression of human cathepsin S in Saccharomyces cerevisiae. Purification and characterization of the recombinant enzyme. J Biol Chem 1993; 268(7)4832–4838
  • Celik T, Iyisoy A, Kursaklioglu H, Yuksel UC. Cyclooxygenase-2 inhibitors dilemma in cardiovascular medicine are all family members bad players?. Int J Cardiol 2007; 116(2)259–260
  • Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, Gordon R, Gresser M, Guay J, Kargman S, Kennedy B, Leblanc Y, Leger S, Mancini J, O¢neill GP, Ouellet M, Patrick D, Percival MD, Perrier H, Prasi P, Rodger I, Tagari P, Therien M, Vickers P, Visco D, Wang Z, Webb J, Wong E, Xu LJ, Young RN, Zamboni R, Riendeau D. Rofecoxib [Vioxx, MK-0966; 4-(4¢-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther 1999; 290: 551–560
  • Cheng FC, Lin A, Feng JJ, Mizoguchi T, Takekoshi H, Kubota H, Kato Y, Naoki Y. Effects of Chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding. J Med Food 2004; 7(2)146–152
  • Dogné JM, Hanson J, de Leval X, Pratico D, Pace-Asciak CR, Drion P, Pirotte B, Ruan KH. From the design to the clinical application of thromboxane modulators. Curr Pharm Des 2006; 12(8)903–923
  • Flannery T, McQuaid S, McGoohan C, McConnell RS, McGregor G, Mirakhur M, Hamilton P, Diamond J, Cran G, Walker B, Scott C, Martin L, Ellison D, Patel C, Nicholson C, Mendelow D, McCormick D, Johnston PG. Cathepsin S expression: an independent prognostic factor in glioblastoma tumours—a pilot study. Int J Cancer 2006; 119(4)854–860
  • Franco SJ, Huttenlocher A. Regulating cell migration: calpains make the cut. J Cell Sci 2005; 118: 3829–3838
  • Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev 2003; 83: 731–801
  • Hourani SM, Cusack NJ. Pharmacological receptors on blood platelets. Pharmacol Rev 1991; 43: 243–298
  • Hsiuan-Lin W, Ruey-Shyang H, Liang-Ping L. Identification of chlorella spp. isolates using ribosomal DNA sequences. Bot Bull Acad Sin 2001; 42: 115–121
  • Inoue K, Mukaiyama Y, Oka H, Misawa H. Clinical effects of Chlorella in hypertensive men. J Jpn Soc Nutr Food Sci 1995; 48: 485–489
  • Ivandic B, Castellani LW, Wang XP, Qiao JH, Mehrabian M, Navab M, Fogelman AM, Grass D, Swanson M, de Beer MC, de Beer F, Lusis AJ. Role of group II secretory phospholipase A2 in atherosclerosis. 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2. Arterioscler Thromb Vasc Biol 1999; 19: 1284–1290
  • Jedinak A, Maliar T. Inhibitors of proteases as anticancer drugs. Neoplasma 2005; 52(3)185–192
  • Jones SC. Relative thromboembolic risks associated with COX-2 inhibitors. Annals Pharmacother 2005; 39(7–8)1249–1259
  • Kanouchi H, Okabe M, Doi S, Yamada H, Tachibana H, Yamada K. Dietary effect of Chlorella pyrenoidosa powder on immunoglobulin productivity of Sprague–Dawley rats. Nippon Shokuhin Kagaku Kaishi 2001; 48: 634–636
  • Katsumata M, Gupta C, Goldman AS. A rapid assay for activity of phospholipase A2 using radioactive substrate. Anal Biochem 1986; 154: 676–681
  • Komiyama K, Hirokawa Y, Morota T, Umezawa I. Antitumor activity and immunological response. Chemotherapy 1986; 32: 302–307
  • Konishi F, Tanaka K, Himeno K, Taniguchi K, Nomoto K. Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): resistance to Meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes. Cancer Immunol Immunother 1985; 19: 73–78
  • Link J, Zipfel S. Advances in cathepsin S inhibitor design. Current Opin Drug Discov Dev 2006; 9(4)471–482
  • Liu W, Spero DM. Cystein protease cathepsin S as a key step in antigen presentation. Drug News Perspect 2004; 17(6)357–363
  • Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104(4)487–501
  • Miyazawa Y, Murayama T, Ooya N, Wang L.F, Tung YC, Yamaguchi N. Immunomodulation by a unicellular green algae (Chlorella pyrenoidosa) in tumor-bearing mice. J Ethnopharmacol 1988; 24: 135–146
  • Montalibet J, Skorey KI, Kennedy BP. Protein tyrosine phosphatase: enzymatic assays. Methods 2005; 35(1)2–8
  • Morita K, Matsueda T, Iida T. Effects of Clorella, spirulina and chlorophyllin on fecal excretion of polychloronated dibenzo-p-dioxins in rats. Jpn J Toxicol Environ Health 1997; 43: 42–47
  • Murachi T, Tanaka K, Itatanaka M, Murakami J. Intracellular Ca2 +-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin). Adv Enzyme Regul 1980; 19: 407–424
  • Murakami T, Iiduka Y, Okamoto K, Oogaki M. Effect of Chlorella on blood pressure, cerebral stroke lesions, hypertensive vascular changes and life-span in spontaneously hypertensive rats. J Jpn Soc Nutr Food Sci 1987; 40: 351–359
  • Paul MK, Mukhopadhyay AK. Tyrosine kinase—role and significance in Cancer. Int J Med Sci 2004; 1: 101–115
  • Potapova O, Laird AD, Nannini MA, Barone A, Li G, Moss K, Cherrington JM, Mandel DB. Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248. Mol Cancer Ther 2006; 5: 1280–1289
  • Riendeau D, Charleson S, Cromlish W, Mancini JA, Wong E, Guay J. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can J Physiol Pharmacol 1997; 75: 1088–1095
  • Samuelsson B, Goldyne M, Granstrom E, Hamberg M, Hammarstrom S, Malmsten C. Prostaglandins and thromboxanes. Annu Rev Biochem 1978; 47: 997–1029
  • Shi GP, Webb AC, Foster KE, Konell JH, Lemere CA, Munger JS, Chapman HA. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem 1994; 269: 11530–11536
  • Shibata S, Orita K, Iwabuchi A, Misawa H. Serum cholesterol lowering action of hardly digestible fraction of chlorella. J Jpn Soc Nutr Food Sci 1998; 52: 100
  • Soraya T, Karine C. Emerging role of cathepsin S in obesity and its associated diseases. Clin Chem Lab Med 2007; 45(3)328–332
  • Stoker AW. Protein tyrosine phosphatases and signaling. J Endocrinol 2005; 185: 19–33
  • Takekoshi H, Mizoguchi T, Komasa Y, Chubachi H, Inoue Y, Imanishi H, Nakano M. Suppression of glutathione S-tansferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa. Oncol Rep 2005a; 14: 409–414
  • Takekoshi, H, Suzuki, G, Chubachi, H, Nakano, M. 2005b. Effect of Chlorella pyrenoidosa on fecal excretion and liver accumulation of polychlorinated dibenzo-p-dioxane in mice. Chemosphere, 59:297–304.
  • Tanaka K, Konishi F, Himeno K, Taniguchi K, Nomoto K. Augmentation of antitumor resistance by a strain of unicellular green algae, Cholrella vulgaris. Cancer Immunol Immunother 1984; 17: 90–94
  • Tanaka K, Koga T, Konishi F, Nakamura M, Mitsuyama M, Himeno K, Nomoto K. Augmentation of host defense by a unicellular green alga, Chlorella vulgaris, to Escherichia coli infection. Infect Immun 1986; 53: 267–271
  • Thurmond RL, Sun S, Karlsson L, Edwards JP. Cathepsin S inhibitors as novel immunomodulators. Curr Opin Investigat Drugs 2005; 6(5)473–482
  • Togashi, N , Ura, N , Higashiura, K , Murakami, H , Shimamoto, K . 2002. Effect of TNF-alpha-converting enzyme inhibitor on insulin resistance in fructose-fed rats. Hypertension, 39(2 Pt 2):578–580.
  • Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem 2006; 281(9)6020–6029
  • Welte S, Baringhaus KH, Schmider W, Muller G, Petry S, Tennagels N. 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases. Anal Biochem 2005; 338(1)32–38
  • Yokoyama Y, Nimura Y, Nagino M, Bland KI, Chaudry IH. Role of thromboxane in producing hepatic injury hepatic stress. Arch Surg 2005; 140(8)801–807

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.