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Comprehensive reviews

Antioxidant, immunomodulatory, and anti-inflammatory effects of Spirulina in disease conditions: a systematic review

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Pages 1047-1056 | Received 16 May 2022, Accepted 16 Oct 2022, Published online: 23 Oct 2022

References

  • Azabji-Kenfack M, Dikosso SE, Loni EG, Onana EA, Sobngwi E, Gbaguidi E, Kana ALN, Nguefack-Tsague G, Von der Weid D, Njoya O, et al. 2011. Potential of spirulina platensis as a nutritional supplement in malnourished HIV-infected adults in Sub-Saharan Africa: a randomised, single-blind study. Nutr Metab Insights. 4:29–37.
  • Badawy AA-B. 2017. Kynurenine pathway of tryptophan metabolism: regulatory and functional aspects. Int J Tryptophan Res. 10:1178646917691938.
  • Chen J-C, Liu KS, Yang T-J, Hwang J-H, Chan Y-C, Lee I-T. 2012. Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells. Nutr Neurosci. 15(6):252–256.
  • Chen WT-L, Yang T-S, Chen H-C, Chen H-H, Chiang H-C, Lin T-C, Yeh C-H, Ke T-W, Chen J-S, Hsiao K-H, et al. 2014. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil–based chemotherapy in colorectal cancer. Nutr Res. 34(7):585–594.
  • Christaki E, Florou-Paneri P, Bonos E. 2011. Microalgae: a novel ingredient in nutrition. Int J Food Sci Nutr. 62(8):794–799.
  • Cingi C, Conk-Dalay M, Cakli H, Bal C. 2008. The effects of spirulina on allergic rhinitis. Eur Arch Otorhinolaryngol. 265(10):1219–1223.
  • El-Shanshory M, Tolba O, El-Shafiey R, Mawlana W, Ibrahim M, El-Gamasy M. 2019. Cardioprotective effects of spirulina therapy in children with beta-thalassemia major. J Pediatr Hematol Oncol. 41(3):202–206.
  • Finamore A, Palmery M, Bensehaila S, Peluso I. 2017. Antioxidant, immunomodulating, and microbial-modulating activities of the sustainable and ecofriendly spirulina. Oxid Med Cell Longev. 2017:3247528–3247514.
  • Gómez-Téllez A, Sierra-Puente D, Muñoz-Gómez R, Ibarra-Pitts A, Guevara-Cruz M, Hernández-Ortega M, Gutiérrez-Salmeán G. 2020. Effects of a low-dose spirulina/turmeric supplement on cardiometabolic and antioxidant serum markers of patients with abdominal obesity. Front Nutr. 7:65.
  • Hernández-Lepe MA, Olivas-Aguirre FJ, Gómez-Miranda LM, Hernández-Torres RP, Manríquez-Torres J de J, Ramos-Jiménez A. 2019. Systematic physical exercise and Spirulina maxima supplementation improve body composition, cardiorespiratory fitness, and blood lipid profile: correlations of a randomized double-blind controlled trial. Antioxidants (Basel). 8(11):507.
  • Hoseini SM, Khosravi-Darani K, Mozafari MR. 2013. Nutritional and medical applications of spirulina microalgae. Mini Rev Med Chem. 13(8):1231–1237.
  • Ismail M, Hossain MF, Tanu AR, Shekhar HU. 2015. Effect of spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients. Biomed Res Int. 2015:486120–486127.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 17(1):1–12.
  • Khan Z, Bhadouria P, Bisen P. 2005. Nutritional and therapeutic potential of spirulina. Curr Pharm Biotechnol. 6(5):373–379.
  • Kim DH, Park MH, Choi YJ, Chung KW, Park CH, Jang EJ, An HJ, Yu BP, Chung HY. 2013. Molecular study of dietary heptadecane for the anti-inflammatory modulation of NF-kB in the aged kidney. PLoS One. 8(3):e59316.
  • Ku CS, Pham TX, Park Y, Kim B, Shin MS, Kang I, Lee J. 2013. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes. Biochim Biophys Acta. 1830(4):2981–2988.
  • Labhe RU, Mani UV, Iyer UM, Mishra M, Jani K, Bhattacharya A. 2001. The effect of spirulina in the treatment of bronchial asthma. J Nutraceuticals Funct Med Foods. 3(4):53–60.
  • Lupatini AL, Colla LM, Canan C, Colla E. 2017. Potential application of microalga Spirulina platensis as a protein source. J Sci Food Agric. 97(3):724–732.
  • Mao TK, Van de Water J, Gershwin ME. 2005. Effects of a spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food. 8(1):27–30.
  • Martínez-Sámano J, Torres-Montes de Oca A, Luqueño-Bocardo O, Torres-Durán P, Juárez-Oropeza M. 2018. Spirulina maxima decreases endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension: results from exploratory controlled clinical trial. Mar Drugs. 16(12):496.
  • Modarresi R, Aminsharifi A, Foroughinia F, Motahari S, Faghihi S. 2019. Impact of spirulina supplementation on semen parameters in patients with idiopathic male infertility: a pilot randomized trial. Urol J. 16(1):78–82.
  • Mohiti S, Zarezadeh M, Naeini F, Tutunchi H, Ostadrahimi A, Ghoreishi Z, Ebrahimi Mamaghani M. 2021. Spirulina supplementation and oxidative stress and pro‐inflammatory biomarkers: a systematic review and meta‐analysis of controlled clinical trials. Clin Exp Pharmacol Physiol. 48(8):1059–1069.
  • Montalvo GEB, Vandenberghe LdS, Soccol VT, Carvalho J d, Soccol CR. 2020. The antihypertensive, antimicrobial and anticancer peptides from arthrospira with therapeutic potential: a mini review. Curr Mol Med. 20(8):593–606.
  • Moradi S, Ziaei R, Foshati S, Mohammadi H, Nachvak SM, Rouhani MH. 2019. Effects of Spirulina supplementation on obesity: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 47:102211.
  • Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al. 2021. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 372:n71.
  • Pugh N, Ross S, ElSohly H, ElSohly M, Pasco D. 2001. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med. 67(8):737–742.
  • Qureshi MA, Garlich JD, Kidd MT. 1996. Dietary Spirulina platensis enhances humoral and cell-mediated immune functions in chickens. Immunopharmacol Immunotoxicol. 18(3):465–476.
  • Ratha SK, Renuka N, Rawat I, Bux F. 2021. Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases. Nutrition. 83:111089.
  • Samuels R, Mani UV, Iyer UM, Nayak US. 2002. Hypocholesterolemic effect of spirulina in patients with hyperlipidemic nephrotic syndrome. J Med Food. 5(2):91–96.
  • Schafer FQ, Wang HP, Kelley EE, Cueno KL, Martin SM, Buettner GR. 2002. Comparing β-carotene, vitamin E and nitric oxide as membrane antioxidants. Biol Chem. 383:3–4.
  • Seghiri R, Kharbach M, Essamri A. 2019. Functional composition, nutritional properties, and biological activities of moroccan Spirulina microalga. J Food Qual. 2019:1–11.
  • Selmi C, Leung PSC, Fischer L, German B, Yang C-Y, Kenny TP, Cysewski GR, Gershwin ME. 2011. The effects of Spirulina on anemia and immune function in senior citizens. Cell Mol Immunol. 8(3):248–254.
  • Shetty P, Shenai P, Chatra L, Rao P. 2013. Efficacy of spirulina as an antioxidant adjuvant to corticosteroid injection in management of oral submucous fibrosis. Indian J Dent Res. 24(3):347–350.
  • Shih MY, Kubo C. 2005. Body shape preference and body satisfaction of Taiwanese and Japanese female college students. Psychiatry Res. 133(2–3):263–271.
  • Silva MROBD, M da Silva G, Silva ALFD, Lima LRAD, Bezerra RP, Marques DDAV. 2021. Bioactive compounds of Arthrospira spp. (Spirulina) with potential anticancer activities: a systematic review. ACS Chem Biol. 16(11):2057–2067.
  • Souza C, Campos PMBGM. 2017. Development and photoprotective effect of a sunscreen containing the antioxidants Spirulina and dimethylmethoxy chromanol on sun-induced skin damage. Eur J Pharm Sci. 104:52–64.
  • Stancioiu F, Mihai D, Papadakis GZ, Tsatsakis A, Spandidos DA, Badiu C. 2019. Treatment for benign thyroid nodules with a combination of natural extracts. Mol Med Rep. 20(3):2332–2338.
  • Szulinska M, Gibas-Dorna M, Miller-Kasprzak E, Suliburska J, Miczke A, Walczak-Gałezewska M, Stelmach-Mardas M, Walkowiak J, Bogdanski P. 2017. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci. 21(10):2473–2481.
  • Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. 2020. Chapter 3: Systematic reviews of effectiveness. In: Aromataris E, Munn Z, editors. JBI manual for evidence synthesis. JBI. Available from: https://synthesismanual.jbi.global
  • Vázquez-Velasco M, González-Torres L, Méndez MT, Bastida S, Benedí J, González-Muñoz MJ, Sánchez-Muniz FJ. 2015. Glucomannan and glucomannan plus spirulina-enriched squid-surimi added to high saturated diet affect glycemia, plasma and adipose leptin and adiponectin levels in growing fa/fa rats. Nutr Hosp. 32(6):2718–2724.
  • Vo T-S, Ngo D-H, Kim S-K. 2015. Nutritional and pharmaceutical properties of microalgal spirulina. In: Kim S-K, editor. Handbook of marine microalgae biotechnology advances. Elsevier; p. 299–308.
  • Wang J, Wang Y, Wang Z, Li L, Qin J, Lai W, Fu Y, Suter PM, Russell RM, Grusak MA, et al. 2008. Vitamin A equivalence of spirulina β-carotene in Chinese adults as assessed by using a stable-isotope reference method. Am J Clin Nutr. 87(6):1730–1737.
  • Winter F, Emakam F, Kfutwah A, Hermann J, Azabji-Kenfack M, Krawinkel M. 2014. The effect of arthrospira platensis capsules on CD4 T-cells and antioxidative capacity in a randomized pilot study of adult women infected with human immunodeficiency virus not under HAART in Yaoundé, Cameroon. Nutrients. 6(7):2973–2986.
  • Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K. 2016. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. Arch Toxicol. 90(8):1817–1840.
  • Yakoot M, Salem A. 2012. Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial. BMC Gastroenterol. 12(1):32.
  • Zarezadeh M, Faghfouri AH, Radkhah N, Foroumandi E, Khorshidi M, Rasouli A, Zarei M, Mohammadzadeh Honarvar N, Hazhir Karzar N, Ebrahimi Mamaghani M. 2021. Spirulina supplementation and anthropometric indices: a systematic review and meta‐analysis of controlled clinical trials. Phytother Res. 35(2):577–586.

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