Antipsychotic treatment – a systematic literature review and meta-analysis of qualitative studies

References

• Alguera-Lara, V., Dowsey, M. M., Ride, J., Kinder, S., & Castle, D. (2017). Shared decision making in mental health: The importance for current clinical practice. Australasian Psychiatry, 25(6), 578–582. doi:10.1177/1039856217734711
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association (APA). (2006). Practice Guidelines for the treatment of psychiatric disorders: Compendium. Arlington, VA: American Psychiatric Pub.
   Google Scholar
• Bjornestad, J., Bronnick, K., Davidson, L., Hegelstad, W. T. V, Joa, I., … Melle, I. (2016). The central role of self-agency in clinical recovery from first episode psychosis. Psychosis, 1–9, 140–148. doi:10.1080/17522439.2016.1198828.
   Google Scholar
• Bjornestad, J., Davidson, L., Joa, I., Larsen, T. K., Hegelstad, W. T. V, Langeveld, J., … Bronnick, K. (2017). Antipsychotic treatment: Experiences of fully recovered service users. Journal of Mental Health, 1–7, 264–270. doi:10.1080/09638237.2017.1294735
   PubMed Web of Science ®Google Scholar
• Bjornestad, J., Joa, I., Larsen, T. K., Langeveld, J., Davidson, L., ten Velden Hegelstad, W., … Johannessen, J. O. (2016). “Everyone Needs a Friend Sometimes”–Social predictors of long-term remission in first episode psychosis. Frontiers in Psychology, 7, 1491. doi:10.3389/fpsyg.2016.01491
   PubMed Web of Science ®Google Scholar
• Bjornestad, J., ten Velden Hegelstad, W., Joa, I., Davidson, L., Larsen, T. K., Melle, I., … Bronnick, K. (2017). “With a little help from my friends” social predictors of clinical recovery in first-episode psychosis. Psychiatry Research, 255, 209–214. doi:10.1016/j.psychres.2017.05.041
   PubMed Web of Science ®Google Scholar
• Bola, J. R., Kao, D. T., & Soydan, H. (2012). Antipsychotic medication for early-episode schizophrenia. Schizophrenia Bulletin, 38(1), 23–25. doi:10.1093/schbul/sbr167
   PubMed Web of Science ®Google Scholar
• Boychuk, C., Lysaght, R., & Stuart, H. (2018). Career decision-making processes of young adults with first-episode psychosis. Qualitative Health Research, 28(6), 1016–1031. doi:10.1177/1049732318761864
   PubMed Web of Science ®Google Scholar
• Bülow, P., Andersson, G., Denhov, A., & Topor, A. (2016). Experience of psychotropic medication–An interview study of persons with psychosis. Issues in Mental Health Nursing, 37(11), 820–828. doi:10.1080/01612840.2016.1224283
   PubMed Web of Science ®Google Scholar
• Carrick, R., Mitchell, A., Powell, R. A., & Lloyd, K. (2004). The quest for well‐being: A qualitative study of the experience of taking antipsychotic medication. Psychology and Psychotherapy: Theory, Research and Practice, 77(1), 19–33. doi:10.1348/147608304322874236
   PubMedGoogle Scholar
• Critical Appraisal Skills Programme (CASP). (2013). Qualitative Research Checklist. Retrieved from http://media.wix.com/ugd/dded87_951541699e9edc71ce66c9bac4734c69.pdf
   Google Scholar
• Chang, Y. T., Tao, S. G., & Lu, C. L. (2013). Qualitative inquiry into motivators for maintaining medication adherence among Taiwanese with schizophrenia. International Journal of Mental Health Nursing, 22(3), 272–278. doi:10.1111/j.1447-0349.2012.00864.x
   PubMed Web of Science ®Google Scholar
• Cocoman, A. M., & Casey, M. (2018). The physical health of individuals receiving antipsychotic medication: A qualitative inquiry on experiences and needs. Issues in Mental Health Nursing, 39(3), 282–289. doi:10.1080/01612840.2017.1386744
   PubMed Web of Science ®Google Scholar
• Das, A. K., Malik, A., & Haddad, P. M. (2014). A qualitative study of the attitudes of patients in an early intervention service towards antipsychotic long-acting injections. Therapeutic Advances in Psychopharmacology, 4(5), 179–185. doi:10.1177/2045125314542098
   PubMedGoogle Scholar
• Davidson, L., Haglund, K. E., Stayner, D. A., Rakfeldt, J., Chinman, M. J., Kraemer Tebes, J. (2001). “It was just realizing… that life isn't one big horror": A qualitative study of supported socialization. Psychiatric Rehabilitation Journal, 24(3), 275. doi:10.1037/h0095084
   PubMed Web of Science ®Google Scholar
• Davidson, L., & Strauss, J. S. (1992). Sense of self in recovery from severe mental illness. British Journal of Medical Psychology, 65(2), 131–145. doi:10.1111/j.2044-8341.1992.tb01693.x
   PubMed Web of Science ®Google Scholar
• Dixon, L. B., Holoshitz, Y., & Nossel, I. (2016). Treatment engagement of individuals experiencing mental illness: Review and update. World Psychiatry, 15(1), 13–20. doi:10.1002/wps.20306
   PubMed Web of Science ®Google Scholar
• Faulkner, A. (2015). Randomised controlled trials: The straitjacket of mental health research? (1st ed.). McPin Talking Point Papers. Retrieved from http://mcpin.org/wp-content/uploads/talking-point-paper-1.pdf
   Google Scholar
• Finfgeld, D. L. (2003). Metasynthesis: The state of the art-so far. Qualitative Health Research, 13(7), 893–904. doi:10.1177/1049732303253462
   PubMed Web of Science ®Google Scholar
• Fusar-Poli, P., Smieskova, R., Kempton, M. J., Ho, B. C., Andreasen, N. C., & Borgwardt, S. (2013). Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neuroscience and Biobehavioral Reviews, 37(8), 1680–1691. doi:10.1016/j.neubiorev.2013.06.001
   PubMed Web of Science ®Google Scholar
• Gault, I., Gallagher, A., & Chambers, M. (2013). Perspectives on medicine adherence in service users and carers with experience of legally sanctioned detention and medication: A qualitative study. Patient Preference and Adherence, 7, 787–799. doi:10.2147/PPA.S44894
   Web of Science ®Google Scholar
• Gee, L., Pearce, E., & Jackson, M. (2003). Quality of life in schizophrenia: A grounded theory approach. Health and Quality of Life Outcomes, 1(1), 31. doi:10.1186/1477-7525-1-31
   PubMedGoogle Scholar
• Geyt, G. L., Awenat, Y., Tai, S., & Haddock, G. (2017). Personal accounts of discontinuing neuroleptic medication for psychosis. Qualitative Health Research, 27(4), 559–572. doi:10.1177/1049732316634047
   PubMed Web of Science ®Google Scholar
• Gray, R., & Deane, K. (2016). What is it like to take antipsychotic medication? A qualitative study of patients with first‐episode psychosis. Journal of Psychiatric and Mental Health Nursing, 23(2), 108–115. doi:10.1111/jpm.12288
   PubMed Web of Science ®Google Scholar
• Hagen, B. F., Nixon, G., & Peters, T. (2010). The greater of two evils? How people with transformative psychotic experiences view psychotropic medications. Ethical Human Psychology and Psychiatry, 12(1), 44–59. doi:10.1891/1559-4343.12.1.44
   Google Scholar
• Harrow, M., Jobe, T. H., Faull, R. N., & Yang, J. (2017). A 20-year multi-followup longitudinal study assessing whether antipsychotic medications contribute to work functioning in schizophrenia. Psychiatry Research, 256, 267–274. doi:10.1016/j.psychres.2017.06.069
   PubMed Web of Science ®Google Scholar
• Hill, C. E. (2012). Consensual qualitative research: A practical resource for investigating social science phenomena. Washington, DC: American Psychological Association.
   Google Scholar
• Hill, C. E., Knox, S., Thompson, B. J., Williams, E. N., Hess, S. A., & Ladany, N. (2005). Consensual qualitative research: An update. Journal of Counseling Psychology, 52(2), 196–205. doi:10.1037/0022-0167.52.2.196
   Web of Science ®Google Scholar
• Hill, C. E., Thompson, B. J., & Williams, E. N. (1997). A guide to conducting consensual qualitative research. Counseling Psychologist, 25(4), 517–572. doi:10.1177/0011000097254001
   Web of Science ®Google Scholar
• Hui, C. L., Lo, M. C., Chan, E. H., Chen, E. S., Ko, R. W., Lee, E. H., … Chen, E. Y. (2016). Perception towards relapse and its predictors in psychosis patients: A qualitative study. Early Intervention in Psychiatry, 11(3), 224–228. doi:10.1111/eip.12378
   Google Scholar
• Hutton, B., Salanti, G., Caldwell, D. M., Chaimani, A., Schmid, C. H., Cameron, C., … Jansen, J. P. (2015). The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and explanations PRISMA extension for network meta-analysis. Annals of Internal Medicine, 162(11), 777–784. doi:10.7326/M14-2385
   PubMed Web of Science ®Google Scholar
• Kane, J. M., Kishimoto, T., & Correll, C. U. (2013). Non‐adherence to medication in patients with psychotic disorders: Epidemiology, contributing factors and management strategies. World Psychiatry, 12(3), 216–226. doi:10.1002/wps.20060
   PubMed Web of Science ®Google Scholar
• Lally, J., Ajnakina, O., Stubbs, B., Cullinane, M., Murphy, K. C., Gaughran, F., & Murray, R. M. (2017). Remission and recovery from first-episode psychosis in adults: Systematic review and meta-analysis of long-term outcome studies. The British Journal of Psychiatry, 211(6), 350–358. doi:10.1192/bjp.bp.117.201475
   PubMed Web of Science ®Google Scholar
• Leng, G., Clark, C., Brian, K., & Partridge, G. (2017). National commitment to shared decision making. BMJ (Clinical Research ed.), 359, j4746. doi:10.1136/bmj.j4746
   PubMedGoogle Scholar
• Leucht, S., Leucht, C., Huhn, M., Chaimani, A., Mavridis, D., Helfer, B., … Davis, J. M. (2017). Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors. American Journal of Psychiatry, 174(10), 927–942. doi:10.1176/appi.ajp.2017.16121358
   PubMed Web of Science ®Google Scholar
• Levitt, H. M., Pomerville, A., & Surace, F. I. (2016). A qualitative meta-analysis examining clients’ experiences of psychotherapy: A new agenda. Psychological Bulletin, 142(8), 801–830. doi:10.1037/bul0000057
   PubMed Web of Science ®Google Scholar
• Lorem, G. F., Frafjord, J. S., Steffensen, M., & Wang, C. E. (2014). Medication and participation: A qualitative study of patient experiences with antipsychotic drugs. Nursing Ethics, 21(3), 347–358. doi:10.1177/0969733013498528
   PubMed Web of Science ®Google Scholar
• Lloyd, H., Lloyd, J., Fitzpatrick, R., & Peters, M. (2017). The role of life context and self-defined well-being in the outcomes that matter to people with a diagnosis of schizophrenia. Health Expectations: An International Journal of Public Participation in Health Care and Health Policy, 20(5), 1061–1072. doi:10.1111/hex.12548
   PubMed Web of Science ®Google Scholar
• Mackin, P., & Thomas, S. H. (2011). Atypical antipsychotic drugs. BMJ, 342(7798), 650–654. doi:10.1136/bmj.d1126
   Google Scholar
• Marder, S. R., & Galderisi, S. (2017). The current conceptualization of negative symptoms in schizophrenia. World Psychiatry, 16(1), 14–24. doi:10.1002/wps.20385
   PubMed Web of Science ®Google Scholar
• McCann, T. V., & Clark, E. (2004). Embodiment of severe and enduring mental illness: Finding meaning in schizophrenia. Issues in Mental Health Nursing, 25(8), 783–798. doi:10.1080/01612840490506365
   PubMedGoogle Scholar
• Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine, 151(4), 264–269. doi:10.7326/0003-4819-151-4-200908180-00135
   PubMed Web of Science ®Google Scholar
• Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., … Stewart, L. A. & PRISMA-P Group. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematisk Reviews, 4(1), g7647. doi:10.1186/2046-4053-4-1
   Google Scholar
• Moilanen, J., Haapea, M., Miettunen, J., Jääskeläinen, E., Veijola, J., Isohanni, M., & Koponen, H. (2013). Characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication – A 10-year follow-up of the Northern Finland 1966 Birth Cohort study. European Psychiatry, 28(1), 53–58. doi:10.1016/j.eurpsy.2011.06.009
   PubMed Web of Science ®Google Scholar
• Moncrieff, J., & Leo, J. (2010). A systematic review of the effects of antipsychotic drugs on brain volume. Psychological Medicine, 40(09), 1409–1422. doi:10.1017/S0033291709992297
   PubMedGoogle Scholar
• Moncrieff, J. (2013). The bitterest pills: The troubling story of antipsychotic drugs. Hampshire: Palgrave Macmillan UK.
   Google Scholar
• Morant, N., Azam, K., Johnson, S., & Moncrieff, J. (2017). The least worst option: User experiences of antipsychotic medication and lack of involvement in medication decisions in a UK community sample. Journal of Mental Health, 27(4), 322–328. doi:10.1080/09638237.2017.1370637
   PubMed Web of Science ®Google Scholar
• Morrison, P., Meehan, T., & Stomski, N. J. (2015). Living with antipsychotic medication side‐effects: The experience of Australian mental health consumers. International Journal of Mental Health Nursing, 24(3), 253–261. doi:10.1111/inm.12110
   PubMed Web of Science ®Google Scholar
• Murphy, A. L., Gardner, D. M., Kisely, S., Cooke, C., Kutcher, S. P., & Hughes, J. (2015). A qualitative study of antipsychotic medication experiences of youth. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 24(1), 61–69.
   Web of Science ®Google Scholar
• Murray, R. M., Quattrone, D., Natesan, S., van Os, J., Nordentoft, M., Howes, O., … Taylor, D. (2016). Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics? British Journal of Psychiatry, 209(05), 361–365. doi:10.1192/bjp.bp.116.182683
   PubMedGoogle Scholar
• National Institute for Clinical Excellence (NICE). (2014). Psychosis and schizophrenia in adults: Prevention and management. NICE Clinical Guideline178. Retrieved from http://www.nice.org.uk/guidance/cg178/evidence/cg178-psychosis-and-schizophrenia-in-adults-full-guideline3
   Google Scholar
• Phillips, L., & McCann, E. (2007). The subjective experiences of people who regularly receive depot neuroleptic medication in the community. Journal of Psychiatric and Mental Health Nursing, 14(6), 578–586. doi:10.1111/j.1365-2850.2007.01145.x
   PubMed Web of Science ®Google Scholar
• Pyne, J. M., McSweeney, J., Kane, H. S., Harvey, S., Bragg, L., & Fischer, E. (2006). Agreement between patients with schizophrenia and providers on factors of antipsychotic medication adherence. Psychiatric Services, 57(8), 1170–1178. doi:10.1176/appi.ps.57.8.1170
   PubMed Web of Science ®Google Scholar
• Rajkumar, A. P., Horsdal, H. T., Wimberley, T., Cohen, D., Mors, O., Borglum, A. D., & Gasse, C. (2017). Endogenous and antipsychotic-related risks for diabetes mellitus in young people with schizophrenia: A Danish Population-Based Cohort Study. American Journal of Psychiatry, 174(7), 686–694. doi:10.1176/appi.ajp.2016.16040442
   PubMed Web of Science ®Google Scholar
• Rhee, T. G., Mohamed, S., & Rosenheck, R. A. (2018). Antipsychotic prescriptions among adults with major depressive disorder in office-based outpatient settings: National trends from 2006 to 2015. The Journal of Clinical Psychiatry, 79(2). doi:10.4088/JCP.17m11970
   PubMed Web of Science ®Google Scholar
• Rogers, A., Day, J., Randall, F., & Bentall, R. P. (2003). Patients’ understanding and participation in a trial designed to improve the management of anti-psychotic medication. Social Psychiatry and Psychiatric Epidemiology, 38(12), 720–727. doi:10.1007/s00127-003-0693-5
   PubMed Web of Science ®Google Scholar
• Rogers, A., Day, J. C., Williams, B., Randall, F., Wood, P., Healy, D., & Bentall, R. P. (1998). The meaning and management of neuroleptic medication: A study of patients with a diagnosis of schizophrenia. Social Science & Medicine, 47(9), 1313–1323. doi:10.1016/S0277-9536(98)00209-3
   PubMed Web of Science ®Google Scholar
• Russo, R. (2018). Through the eyes of the observed: Re-directing research on psychiatric drugs. Talking Point Papers. Vol. 3. London: McPin Foundation. Retrieved from http://mcpin.org/wp-content/uploads/talking-point-paper-3-final.pdf
   Google Scholar
• Schauer, C., Everett, A., del Vecchio, P., & Anderson, L. (2007). Promoting the value and practice of shared decision-making in mental health care. Psychiatric Rehabilitation Journal, 31(1), 54–61.
   PubMed Web of Science ®Google Scholar
• Slade, M. (2017). Implementing shared decision making in routine mental health care. World Psychiatry, 16(2), 146–153. doi:10.1002/wps.20412
   PubMed Web of Science ®Google Scholar
• Sohler, N., Adams, B., Barnes, D., Cohen, G., Prins, S., & Schwartz, S. (2016). Weighing the evidence for harm from long-term treatment with antipsychotic medications: A systematic review. The American Journal of Orthopsychiatry, 86(5), 477–485. doi:10.1037/ort0000106
   PubMed Web of Science ®Google Scholar
• Stewart, D. C., Anthony, G. B., & Chesson, R. (2010). ‘It's not my job. I’m the patient not the doctor’: Patient perspectives on medicines management in the treatment of schizophrenia. Patient Education and Counseling, 78(2), 212–217. doi:10.1016/j.pec.2009.06.016
   PubMed Web of Science ®Google Scholar
• Stovell, D., Morrison, A. P., Panayiotou, M., & Hutton, P. (2016). Shared treatment decision-making and empowerment-related outcomes in psychosis: Systematic review and meta-analysis. The British Journal of Psychiatry, 209, 23–28. doi:10.1192/bjp.bp.114.158931
   PubMed Web of Science ®Google Scholar
• Svedberg, B., Backenroth-Ohsako, G., & Lützén, K. (2003). On the path to recovery: Patients’ experiences of treatment with long‐acting injections of antipsychotic medication. International Journal of Mental Health Nursing, 12(2), 110–118. doi:10.1046/j.1440-0979.2003.00277.x
   PubMed Web of Science ®Google Scholar
• Thomas, J., & Harden, A. (2008). Methods for the thematic synthesis of qualitative research in systematic reviews. BMC Medical Research Methodology, 8, 45. doi:10.1186/1471-2288-8-45
   Web of Science ®Google Scholar
• Thomas, N. (2015). What's really wrong with cognitive behavioral therapy for psychosis? Frontiers in Psychology, 6, 323. doi:10.3389/fpsyg.2015.00323
   PubMed Web of Science ®Google Scholar
• Timulak, L. (2009). Meta-analysis of qualitative studies: A tool for reviewing qualitative research findings in psychotherapy. Psychotherapy Research, 19(4–5), 591–600. doi:10.1080/10503300802477989
   PubMed Web of Science ®Google Scholar
• Timulak, L. (2014). Qualitative meta-analysis. In U. Flick (Ed.), The SAGE handbook of qualitative analysis (pp. 481–495). London: SAGE Publications Ltd.
   Google Scholar
• Tranulis, C., Goff, D., Henderson, D. C., & Freudenreich, O. (2011). Becoming adherent to antipsychotics: A qualitative study of treatment-experienced schizophrenia patients. Psychiatric Services, 62(8), 888–892. doi:10.1176/ps.62.8.pss6208_0888
   PubMed Web of Science ®Google Scholar
• Usher, K. (2001). Taking neuroleptic medications as the treatment for schizophrenia: A phenomenological study. Australian and New Zealand Journal of Mental Health Nursing, 10(3), 145–155. doi:10.1046/j.1440-0979.2001.00205.x
   PubMedGoogle Scholar
• Usher, K., Park, T., & Foster, K. (2013). The experience of weight gain as a result of taking second‐generation antipsychotic medications: The mental health consumer perspective. Journal of Psychiatric and Mental Health Nursing, 20(9), 801–806. doi:10.1111/jpm.12019
   PubMed Web of Science ®Google Scholar
• Vancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., … Correll, C. U. (2015). Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: A systematic review and meta‐analysis. World Psychiatry, 14(3), 339–347. doi:10.1002/wps.20252
   PubMed Web of Science ®Google Scholar
• Vandyk, A. D., & Baker, C. (2012). Qualitative descriptive study exploring schizophrenia and the everyday effect of medication‐induced weight gain. International Journal of Mental Health Nursing, 21(4), 349–357. doi:10.1111/j.1447-0349.2011.00790.x
   PubMed Web of Science ®Google Scholar
• Vedana, K. G. G., & Miasso, A. I. (2014). The meaning of pharmacological treatment for schizophrenic patients. Revista Latino-Americana de Enfermagem, 22(4), 670–678. doi:10.1590/0104-1169.3427.2466
   PubMed Web of Science ®Google Scholar
• Wunderink, L., Nieboer, R. M., Wiersma, D., Sytema, S., & Nienhuis, F. J. (2013). Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: Long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry, 70(9), 913–920. doi:10.1001/jamapsychiatry.2013.19
   PubMed Web of Science ®Google Scholar
• Wykes, T., Evans, J., Paton, C., Barnes, T., Taylor, D., Bentall, R., … Vitoratou, S. (2017). What side effects are problematic for patients prescribed antipsychotic medication? The Maudsley Side Effects (MSE) measure for antipsychotic medication. Psychological Medicine, 47, 2369–2378. doi:10.1017/S0033291717000903
   PubMed Web of Science ®Google Scholar
• Yeisen, R. A., Bjornestad, J., Joa, I., Johannessen, J. O., & Opjordsmoen, S. (2017). Experiences of antipsychotic use in patients with early psychosis: A two-year follow-up study. BMC Psychiatry, 17(1), 299. doi:10.1186/s12888-017-1425-9
   PubMedGoogle Scholar
• Zarea, K., Fereidooni-Moghadam, M., & Hakim, A. (2016). Adherence to medication regimen in patients with severe and chronic psychiatric disorders: A qualitative study. Issues in Mental Health Nursing, 37(11), 868–874. doi:10.1080/01612840.2016.1239147
   PubMed Web of Science ®Google Scholar
• Zipursky, R. B., & Agid, O. (2015). Recovery, not progressive deterioration, should be the expectation in schizophrenia. World Psychiatry, 14(1), 94–96. doi:10.1002/wps.20194
   PubMed Web of Science ®Google Scholar