More than half of persons with lower limb amputation suffer from chronic back pain or residual limb pain: a systematic review with meta-analysis

References

• Czerniecki JM, Ehde DM. Chronic pain after low extremity amputation. Crit Rev Phys Rehabil Med. 2003;15(3–4):24–332.
   Google Scholar
• Loeser JD. Classification of chronic pain. 2nd ed. (revised). Descriptions of chronic pain syndromes and definitions of pain terms. Washington, USA: IASP Press. International Association for the Study of Pain; 2011.
   Google Scholar
• Davis RW. Phantom sensation, phantom pain, and stump pain. Arch Phys Med Rehabil. 1993;74(1):79–91.
   PubMed Web of Science ®Google Scholar
• Ephraim PL, Wegener ST, MacKenzie EJ, et al. Phantom pain, residual limb pain, and back pain in amputees: results of a national survey. Arch Phys Med Rehabil. 2005;86(10):1910–1919.
   PubMed Web of Science ®Google Scholar
• Ehde DM, Czerniecki JM, Smith DG, et al. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000;81(8):1039–1044.
   PubMed Web of Science ®Google Scholar
• Ehde DM, Smith DG, Czerniecki JM, et al. Back pain as a secondary disability in persons with lower limb amputations. Arch Phys Med Rehabil. 2001;82(6):731–734.
   PubMed Web of Science ®Google Scholar
• Jaegers SM, Arendzen JH, de Jongh HJ. Prosthetic gait of unilateral transfemoral amputees: a kinematic study. Arch Phys Med Rehabil. 1995;76(8):736–743.
   PubMed Web of Science ®Google Scholar
• Friberg O. Biomechanical significance of the correct length of lower limb prostheses: a clinical and radiological study. Prosthet Orthot Int. 1984;8(3):124–129.
   PubMed Web of Science ®Google Scholar
• Gailey R, Allen K, Castles J, et al. Review of secondary physical conditions associated with lower-limb amputation and long-term prosthesis use. J Rehabil Res Dev. 2008;45(1):15–29.
   PubMedGoogle Scholar
• Wasser JG, Vincent KR, Herman DC, et al. Potential lower extremity amputation-induced mechanisms of chronic low back pain: role for focused resistance exercise. Disabil Rehabil. 2019. DOI:https://doi.org/10.1080/09638288.2019.1610507
   Google Scholar
• Norvell DC, Czerniecki JM, Reiber GE, et al. The prevalence of knee pain and symptomatic knee osteoarthritis among veteran traumatic amputees and nonamputees. Arch Phys Med Rehabil. 2005;86(3):487–493.
   PubMed Web of Science ®Google Scholar
• Morgan SJ, Friedly JL, Amtmann D, et al. Cross-sectional assessment of factors related to pain intensity and pain interference in lower limb prosthesis users. Arch Phys Med Rehabil. 2017;98(1):105–113.
   PubMed Web of Science ®Google Scholar
• Behr J, Friedly J, Molton I, et al. Pain and pain-related interference in adults with lower-limb amputation: comparison of knee-disarticulation, transtibial, and transfemoral surgical sites. J Rehabil Res Dev. 2009;46(7):963–972.
   PubMedGoogle Scholar
• Christensen J, Ipsen T, Doherty P, et al. Physical and social factors determining quality of life for veterans with lower-limb amputation(s): a systematic review. Disabil Rehabil. 2016;38(24):2345–2353.
   PubMed Web of Science ®Google Scholar
• Desmond D, Gallagher P, Henderson-Slater D, et al. Pain and psychosocial adjustment to lower limb amputation amongst prosthesis users. Prosthet Orthot Int. 2008;32(2):244–252.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
   PubMed Web of Science ®Google Scholar
• Rostom A, Dubé C, Cranney A, et al. Appendix D. Quality assessment forms. Cross-sectional/prevalence study quality. Rockville (MD): Agency for Healthcare Research and Quality (US). Celiac disease. Evidence reports/technology assessments, no. 104; 2016. Available from: https://www.ncbi.nlm.nih.gov/books/NBK35156/
   Google Scholar
• Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10.
   PubMedGoogle Scholar
• Bodde MI, Dijkstra PU, den Dunnen WF, et al. Therapy-resistant complex regional pain syndrome type I: to amputate or not? J Bone Joint Surg Am. 2011;93:1799–1805.
   PubMed Web of Science ®Google Scholar
• Rahimi A, Mousavi B, Soroush M, et al. Pain and health-related quality of life in war veterans with bilateral lower limb amputations. Trauma Mon. 2012;17(2):282–286.
   PubMedGoogle Scholar
• Ashraf A, Shojaee H, Mousavi B, et al. Impact of pain in vertebral column on activities of daily living in the Iranian amputees with bilateral lower limb amputation. Disabil Rehabil. 2012;34(10):869–872.
   PubMed Web of Science ®Google Scholar
• Ebrahimzadeh MH, Fattahi AS. Long-term clinical outcomes of Iranian veterans with unilateral transfemoral amputation. Disabil Rehabil. 2009;31(22):1873–1877.
   PubMed Web of Science ®Google Scholar
• Ebrahimzadeh MH, Hariri S. Long-term outcomes of unilateral transtibial amputations. Mil Med. 2009;174(6):593–597.
   PubMed Web of Science ®Google Scholar
• Ebrahimzadeh MH, Rajabi MT. Long-term outcomes of patients undergoing war-related amputations of the foot and ankle. J Foot Ankle Surg. 2007;46(6):429–433.
   PubMedGoogle Scholar
• Hanley MA, Jensen MP, Smith DG, et al. Preamputation pain and acute pain predict chronic pain after lower extremity amputation. J Pain. 2007;8(2):102–109.
   PubMed Web of Science ®Google Scholar
• Raichle KA, Hanley MA, Molton I, et al. Prosthesis use in persons with lower- and upper-limb amputation. J Rehabil Res Dev. 2008;45(7):961–972.
   PubMedGoogle Scholar
• Devan H, Hendrick P, Hale L, et al. Exploring factors influencing low back pain in people with nondysvascular lower limb amputation: a national survey. Pm R. 2017;9(10):949–959.
   PubMedGoogle Scholar
• Akyol Y, Tander B, Goktepe AS, et al. Quality of life in patients with lower limb amputation: does it affect post-amputation pain, functional status, emotional status and perception of body image? J Musculoskelet Pain. 2013;21(4):334–340.
   Web of Science ®Google Scholar
• Berke GM, Fergason J, Milani JR, et al. Comparison of satisfaction with current prosthetic care in veterans and servicemembers from Vietnam and OIF/OEF conflicts with major traumatic limb loss. J Rehabil Res Dev. 2010;47(4):361–371.
   PubMedGoogle Scholar
• Sinha R, van den Heuvel WJ, Arokiasamy P. Factors affecting quality of life in lower limb amputees. Prosthet Orthot Int. 2011;35(1):90–96.
   PubMed Web of Science ®Google Scholar
• Pohjolainen T. A clinical evaluation of stumps in lower limb amputees. Prosthet Orthot Int. 1991;15(3):178–184.
   PubMed Web of Science ®Google Scholar
• McCartney CJL, Charles DHM, Cooper GG, et al. Pain and disability following lower limb amputation – a quantitative and qualitative study. Pain Clin. 1999;11(4):293–300.
   Google Scholar
• Luetmer M, Mundell B, Kremers HM, et al. Low back pain in adults with transfemoral amputation: a retrospective population-based study. Pm R. 2019;11(9):926–933.
   PubMedGoogle Scholar
• Welke B, Jakubowitz E, Seehaus F, et al. The prevalence of osteoarthritis: higher risk after transfemoral amputation? A database analysis with 1,569 amputees and matched controls. PLoS One. 2019;14(1):e0210868.
   PubMed Web of Science ®Google Scholar
• Richardson C, Glenn S, Nurmikko T, et al. Incidence of phantom phenomena including phantom limb pain 6 months after major lower limb amputation in patients with peripheral vascular disease. Clin J Pain. 2006;22(4):353–358.
   PubMed Web of Science ®Google Scholar
• Larbig W, Andoh J, Huse E, et al. Pre- and postoperative predictors of phantom limb pain. Neurosci Lett. 2019;702:44–50.
   PubMed Web of Science ®Google Scholar
• Burke MJ, Roman V, Wright V. Bone and joint changes in lower limb amputees. Ann Rheum Dis. 1978;37(3):252–254.
   PubMed Web of Science ®Google Scholar
• Kramer J, Heisel JM, Ullrich CH. Late results of patients with amputation of the thigh (author’s transl). Z Orthop Ihre Grenzgeb. 1979;117(5):801–807.
   PubMed Web of Science ®Google Scholar
• Hoaglund FT, Jergesen HE, Wilson L, et al. Evaluation of problems and needs of veteran lower-limb amputees in the San Francisco Bay Area during the period 1977–1980. J Rehabil Res Dev. 1983;20:57–71.
   Google Scholar
• Jensen TS, Krebs B, Nielsen J, et al. Immediate and long-term phantom limb pain in amputees: incidence, clinical characteristics and relationship to pre-amputation limb pain. Pain. 1985;21(3):267–278.
   PubMed Web of Science ®Google Scholar
• Smith DG, Ehde DM, Legro MW, et al. Phantom limb, residual limb, and back pain after lower extremity amputations. Clin Orthop Relat Res. 1999;361:29–38.
   PubMed Web of Science ®Google Scholar
• Dillingham TR, Pezzin LE, MacKenzie EJ, et al. Use and satisfaction with prosthetic devices among persons with trauma-related amputations: a long-term outcome study. Am J Phys Med Rehabil. 2001;80(8):563–571.
   PubMed Web of Science ®Google Scholar
• Gallagher P, Allen D, Maclachlan M. Phantom limb pain and residual limb pain following lower limb amputation: a descriptive analysis. Disabil Rehabil. 2001;23(12):522–530.
   PubMed Web of Science ®Google Scholar
• Hagberg K, Branemark R. Consequences of non-vascular trans-femoral amputation: a survey of quality of life, prosthetic use and problems. Prosthet Orthot Int. 2001;25(3):186–194.
   PubMed Web of Science ®Google Scholar
• Stam HJ, Dommisse AM, Bussmann HJ. Prevalence of low back pain after transfemoral amputation related to physical activity and other prosthesis-related parameters. Disabil Rehabil. 2004;26(13):794–797.
   PubMed Web of Science ®Google Scholar
• Friel K, Domholdt E, Smith DG. Physical and functional measures related to low back pain in individuals with lower-limb amputation: an exploratory pilot study. J Rehabil Res Dev. 2005;42(2):155–166.
   PubMedGoogle Scholar
• Kulkarni J, Gaine WJ, Buckley JG, et al. Chronic low back pain in traumatic lower limb amputees. Clin Rehabil. 2005;19(1):81–86.
   PubMed Web of Science ®Google Scholar
• Kusljugic A, Kapidzic-Durakovic S, Kudumovic Z, et al. Chronic low back pain in individuals with lower-limb amputation. Bosn J Basic Med Sci. 2006;6:67–70.
   PubMedGoogle Scholar
• Smith E, Comiskey C, Ryall N. Prevalence and patterns of back pain and residual limb pain in lower limb amputees at the National Rehabilitation Hospital. Ir J Med Sci. 2008;177(1):53–57.
   PubMed Web of Science ®Google Scholar
• Taghipour H, Moharamzad Y, Mafi AR, et al. Quality of life among veterans with war-related unilateral lower extremity amputation: a long-term survey in a prosthesis center in Iran. J Orthop Trauma. 2009;23:525–530.
   PubMed Web of Science ®Google Scholar
• Hammarlund CS, Carlstrom M, Melchior R, et al. Prevalence of back pain, its effect on functional ability and health-related quality of life in lower limb amputees secondary to trauma or tumour: a comparison across three levels of amputation. Prosthet Orthot Int. 2011;35(1):97–105.
   PubMed Web of Science ®Google Scholar
• Devan H, Tumilty S, Smith C. Physical activity and lower-back pain in persons with traumatic transfemoral amputation: a national cross-sectional survey. J Rehabil Res Dev. 2012;49(10):1457–1466.
   PubMedGoogle Scholar
• Sprunger NM, Laferrier JF, Collins DP, et al. Utilization of prostheses and mobility-related assistive technology among service members and veterans from Vietnam and Operation Iraqi Freedom/Operation Enduring Freedom. J Prosthet Orthot. 2012;24:144–152.
   Google Scholar
• Akarsu S, Tekin L, Safaz I, et al. Quality of life and functionality after lower limb amputations: comparison between uni- vs. bilateral amputee patients. Prosthet Orthot Int. 2013;37(1):9–13.
   PubMed Web of Science ®Google Scholar
• Ebrahimzadeh MH, Kachooei AR, Soroush MR, et al. Long-term clinical outcomes of war-related hip disarticulation and transpelvic amputation. J Bone Joint Surg Am. 2013;95:e114.
   PubMedGoogle Scholar
• Richardson C, Crawford K, Milnes K, et al. A clinical evaluation of postamputation phenomena including phantom limb pain after lower limb amputation in dysvascular patients. Pain Manag Nurs. 2015;16(4):561–569.
   PubMed Web of Science ®Google Scholar
• Buchheit T, Van de Ven T, Hsia HL, et al. Pain phenotypes and associated clinical risk factors following traumatic amputation: results from Veterans Integrated Pain Evaluation Research (VIPER). Pain Med. 2016;17(1):149–161.
   PubMed Web of Science ®Google Scholar
• George J, Newman JM, Caravella JW, et al. Predicting functional outcomes after above knee amputation for infected total knee arthroplasty. J Arthroplasty. 2017;32(2):532–536.
   PubMed Web of Science ®Google Scholar
• Kelle B, Kozanoğlu E, Biçer ÖS, et al. Association between phantom limb complex and the level of amputation in lower limb amputee. Acta Orthop Traumatol Turc. 2017;51(2):142–145.
   PubMed Web of Science ®Google Scholar
• Yaşar E, Tok F, Kesikburun S, et al. Epidemiologic data of trauma-related lower limb amputees: a single center 10-year experience. Injury. 2017;48(2):349–352.
   PubMed Web of Science ®Google Scholar
• Esfandiari E, Yavari A, Karimi A, et al. Long-term symptoms and function after war-related lower limb amputation: a national cross-sectional study. Acta Orthop Traumatol Turc. 2018;52(5):348–351.
   PubMed Web of Science ®Google Scholar
• Allami M, Faraji E, Mohammadzadeh F, et al. Chronic musculoskeletal pain, phantom sensation, phantom and stump pain in veterans with unilateral below-knee amputation. Scand J Pain. 2019;19(4):779–787.
   Google Scholar
• Devan H, Carman A, Hendrick P, et al. Spinal, pelvic, and hip movement asymmetries in people with lower-limb amputation: systematic review. J Rehabil Res Dev. 2015;52(1):1–19.
   PubMedGoogle Scholar
• Nijs J, Clark J, Malfliet A, et al. In the spine or in the brain? Recent advances in pain neuroscience applied in the intervention for low back pain. Clin Exp Rheumatol. 2017;35(5):108–115.
   PubMed Web of Science ®Google Scholar
• Hucho T, Levine JD. Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron. 2007;55(3):365–376.
   PubMed Web of Science ®Google Scholar
• Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895–926.
   PubMed Web of Science ®Google Scholar
• Merskey H, Bogduk N. Part III: pain terms, a current list with definitions and notes on usage. In: Merskey H, Bogduk N, editors. Classification of chronic pain. 2nd ed. Seattle (WA): IASP Press; 1994. p. 209–201.
   Google Scholar
• Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl.):S2–S15.
   PubMed Web of Science ®Google Scholar
• Ahuja V, Thapa D, Ghai B. Strategies for prevention of lower limb post-amputation pain: a clinical narrative review. J Anaesthesiol Clin Pharmacol. 2018;34(4):439–449.
   PubMed Web of Science ®Google Scholar
• Dionne CE, Dunn KM, Croft PR. Does back pain prevalence really decrease with increasing age? A systematic review. Age Ageing. 2006;35(3):229–234.
   PubMed Web of Science ®Google Scholar
• Cassidy JD, Carroll LJ, Cote P. The Saskatchewan health and back pain survey. The prevalence of low back pain and related disability in Saskatchewan adults. Spine (Phila Pa 1976). 1998;23(17):1860–1866; discussion 1867.
   PubMed Web of Science ®Google Scholar
• Deyo RA, Mirza SK, Martin BI. Back pain prevalence and visit rates: estimates from U.S. national surveys, 2002. Spine (Phila Pa 1976). 2006;31(23):2724–2727.
   PubMed Web of Science ®Google Scholar
• Skovron ML, Szpalski M, Nordin M, et al. Sociocultural factors and back pain. A population-based study in Belgian adults. Spine (Phila Pa 1976). 1994;19(2):129–137.
   PubMed Web of Science ®Google Scholar
• Papageorgiou AC, Croft PR, Ferry S, et al. Estimating the prevalence of low back pain in the general population. Evidence from the South Manchester Back Pain Survey. Spine (Phila Pa 1976). 1995;20(17):1889–1894.
   PubMed Web of Science ®Google Scholar
• Izumi Y, Satterfield K, Lee S, et al. Risk of reamputation in diabetic patients stratified by limb and level of amputation: a 10-year observation. Diabetes Care. 2006;29(3):566–570.
   PubMed Web of Science ®Google Scholar
• World Health Organization. International Classification of Functioning, Disability and Health (ICF). Geneva: WHO; 2001.
   Google Scholar
• Fleury AM, Salih SA, Peel NM. Rehabilitation of the older vascular amputee: a review of the literature. Geriatr Gerontol Int. 2013;13(2):264–273.
   PubMed Web of Science ®Google Scholar