Administration of cyclic glycine-proline during infancy improves adult spatial memory, astrocyte plasticity, vascularization and GluR-1 expression in rats

References

• Torres-Aleman I. Toward a comprehensive neurobiology of IGF-I. Dev Neurobiol. 2010;70(5):384–96.
   PubMed Web of Science ®Google Scholar
• Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Ramenghi LA, Löfqvist C, et al. Role of insulinlike growth factor 1 in fetal development and in the early postnatal life of premature infants. Am J Perinatol. 2016;33(11):1067–71. doi:10.1055/s-0036-1586109.
   PubMed Web of Science ®Google Scholar
• Synnes A, Hicks M. Neurodevelopmental outcomes of preterm children at school age and beyond. Clin Perinatol. 2018;45(3):393–408. doi:10.1016/j.clp.2018.05.002.
   PubMed Web of Science ®Google Scholar
• Lopez-Lopez C, LeRoith D, Torres-Aleman I. Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc Natl Acad Sci U S A. 2004;101(26):9833–8.
   PubMed Web of Science ®Google Scholar
• Bianchi VE, Locatelli V, Rizzi L. Neurotrophic and neuroregenerative effects of GH/IGF1. Int J Mol Sci. 2017;18(11). doi:10.3390/ijms18112441.
   Web of Science ®Google Scholar
• Ranke MB. Insulin-like growth factor binding-protein-3 (IGFBP-3). Best Pract Res Clin Endocrinol Metab. 2015;29(5):701–11. doi:10.1016/j.beem.2015.06.003.
   PubMed Web of Science ®Google Scholar
• Baker AM, Batchelor DC, Thomas GB, Wen JY, Rafiee M, Lin H, et al. Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat. Neuropeptides. 2005;39(2):81–7.
   PubMed Web of Science ®Google Scholar
• Sara VR, Carlsson-Skwirut C, Drakenberg K, Giacobini MB, Mirmiran M, et al. The biological role of truncated insulin-like growth factor-1 and the tripeptide GPE in the central nervous system. Ann N Y Acad Sci. 1993: 692:183–91.
   PubMed Web of Science ®Google Scholar
• Yamamoto H, Murphy LJ. Generation of des-(1-3) insulin-like growth factor-I in serum by an acid protease. Endocrinology. 1994;135:2432–9.
   PubMedGoogle Scholar
• Guan J, Harris P, Brimble M, Lei Y, Lu J, Yang Y, et al. The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders. Expert Opin Ther Targets. 2015;19(6):785–93. doi:10.1517/14728222.2015.1010514.
   PubMed Web of Science ®Google Scholar
• Guan J, Gluckman P, Yang P, Krissansen G, Sun X, Zhou Y, et al. Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1. Sci Rep. 2014;4:4388. doi:10.1038/srep04388.
   PubMed Web of Science ®Google Scholar
• Fan D, Krishnamurthi R, Harris P, Barber PA, Guan J. Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients. Ann Clin Transl Neurol. 2019;6(4):669–77. doi:10.1002/acn3.743.
   PubMed Web of Science ®Google Scholar
• Guan J, Singh-Mallah G, Liu K, Thorstensen E, Shorten P, Mitchell EA, et al. The role for cyclic glycine-proline, a biological regulator of insulin-like growth factor-1 in pregnancy-related obesity and weight changes. J Biol Regul Homeost Agents. 2018;32(3):465–78.
   PubMed Web of Science ®Google Scholar
• Singh-Mallah G, Singh K, McMahon CD, Harris P, Brimble MA, Thorstensen E, et al. Maternally administered cyclic glycine-proline increases insulin-like growth factor-1 bioavailability and novelty recognition in developing offspring. Endocrinology. 2016;157(8):3130–9. doi:10.1210/en.2016-1189.
   PubMed Web of Science ®Google Scholar
• Fan D, Pitcher T, Dalrymple-Alford J, MacAskill M, Anderson T, Guan J. Changes of plasma cGP/IGF-1 molar ratio with age is associated with cognitive status of Parkinson disease. Alzheimers Dement (Amst. 2020;12(1):e12025, doi:10.1002/dad2.12025.
   PubMedGoogle Scholar
• Galante L, Pundir S, Lagström H, Rautava S, Reynolds CM, Milan AM, et al. Growth factor concentrations in human milk Are associated with infant weight and BMI from birth to 5 years. Front Nutr. 2020;7:110, doi:10.3389/fnut.2020.00110.
   PubMed Web of Science ®Google Scholar
• Krishnamurthi R, Mathai S, Kim H, Zhang R, Guan J. A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA induced motor deficit in rats. Br J Pharmacol. 2008;156(4):662–72.
   Web of Science ®Google Scholar
• Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. ILAR J. 2014;55(2):310–32. doi:10.1093/ilar/ilu013.
   PubMed Web of Science ®Google Scholar
• Guan J, MacGibbon A, Fong B, Zhang R, Liu K, Rowan A, et al. Long-term supplementation with beta serum concentrate (BSC), a complex of milk lipids, during post-natal brain development improves memory in rats. Nutrients. 2015;7(6):4526–41. doi:10.3390/nu7064526.
   PubMed Web of Science ®Google Scholar
• Huang L, Nakamura Y, Lo EH, Hayakawa K. Astrocyte signaling in the neurovascular unit after central nervous system injury. Int J Mol Sci. 2019;20(2). doi:10.3390/ijms20020282.
   Web of Science ®Google Scholar
• Nuriya M, Hirase H. Involvement of astrocytes in neurovascular communication. Prog Brain Res. 2016;225:41–62. doi:10.1016/bs.pbr.2016.02.001.
   PubMed Web of Science ®Google Scholar
• Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science. 2008;322(5907):1551–5. doi:10.1126/science.1164022.
   PubMed Web of Science ®Google Scholar
• Hatip-Al-Khatib I, Iwasaki K, Egashira N, Ishibashi D, Mishima K, Fujiwara M. Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion. J Pharmacol Sci. 2007;103(1):83–91. doi:10.1254/jphs.fp0061229.
   PubMed Web of Science ®Google Scholar
• Matute C, Gutiérrez-Igarza K, Río C, Miledi R. Glutamate receptors in astrocytic end-feet. Neuroreport. 1994;5(10):1205–8. doi:10.1097/00001756-199406020-00011.
   PubMed Web of Science ®Google Scholar
• Li F, Liu K, Wang A, Harris PWR, Vickers MH, Guan J. Cyclic glycine-proline administration normalizes high-fat diet-induced synaptophysin expression in obese rats. Neuropeptides. 2019;76:101935), doi:10.1016/j.npep.2019.05.006.
   PubMed Web of Science ®Google Scholar
• Guillermo RB, Yang P, Vickers MH, McJarrow P, Guan J. Supplementation with complex milk lipids during brain development promotes neuroplasticity without altering myelination or vascular density. Food Nutr Res. 2015;59:25765), doi:10.3402/fnr.v59.25765.
   PubMed Web of Science ®Google Scholar
• Anzabi M, Ardalan M, Iversen NK, Rafati AH, Hansen B, Østergaard L. Hippocampal atrophy following subarachnoid hemorrhage correlates with disruption of astrocyte morphology and capillary coverage by AQP4. Front Cell Neurosci. 2018;12:19), doi:10.3389/fncel.2018.00019.
   PubMed Web of Science ®Google Scholar
• Ardalan M, Rafati AH, Nyengaard JR, Wegener G. Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus. Br J Pharmacol. 2017;174(6):483–92. doi:10.1111/bph.13714.
   PubMed Web of Science ®Google Scholar
• Ardalan M, Wegener G, Polsinelli B, Madsen TM, Nyengaard JR. Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression. Hippocampus. 2016;26(11):1414–23. doi:10.1002/hipo.22617.
   PubMed Web of Science ®Google Scholar
• Megías M, Emri Z, Freund TF, Gulyás AI. Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience. 2001;102(3):527–40. doi:10.1016/s0306-4522(00)00496-6.
   PubMed Web of Science ®Google Scholar
• Larsen JO, Gundersen HJ, Nielsen J. Global spatial sampling with isotropic virtual planes: estimators of length density and total length in thick, arbitrarily orientated sections. J Microsc. 1998;191(3):238–48. doi:10.1046/j.1365-2818.1998.00365.x.
   PubMedGoogle Scholar
• Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc. 2006;1(2):848–58.
   PubMed Web of Science ®Google Scholar
• Li F, Liu K, Gray C, Harris P, Reynolds CM, Vickers MH, et al. Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutr Metab Cardiovasc Dis. 2019. doi:10.1016/j.numecd.2019.09.016
   Web of Science ®Google Scholar
• Bernardinelli Y, Muller D, Nikonenko I. Astrocyte-synapse structural plasticity. Neural Plast. 2014 2014: 232105, doi:10.1155/2014/232105.
   PubMed Web of Science ®Google Scholar
• Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, et al. The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model. J Psychopharmacol. 2007;21(6):611–9. doi:10.1177/0269881106071335.
   PubMed Web of Science ®Google Scholar
• Huganir RL, Nicoll RA. AMPARs and synaptic plasticity: the last 25 years. Neuron. 2013;80(3):704–17. doi:10.1016/j.neuron.2013.10.025.
   PubMed Web of Science ®Google Scholar
• Gudasheva TA, Grigoriev VV, Koliasnikova KN, Zamoyski VL, Seredenin SB. Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors. Dokl Biochem Biophys. 2016;471(1):387–9. doi:10.1134/s160767291606003x.
   PubMed Web of Science ®Google Scholar
• Guan J, Zhang R, Dale-Gandar L, Hodgkinson S, Vickers MH. NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat. Behav Brain Res. 2010;210(2):221–8. doi:10.1016/j.bbr.2010.02.039.
   PubMed Web of Science ®Google Scholar
• Zhou B, Zuo Y-X, Jiang R-T. Astrocyte morphology: diversity, plasticity, and role in neurological diseases. CNS Neurosci Ther. 2019;25(6):665–73. doi:10.1111/cns.13123.
   PubMed Web of Science ®Google Scholar
• Sonnewald U, Schousboe A. Introduction to the glutamate-glutamine cycle. Adv Neurobiol. 2016;13:1–7. doi:10.1007/978-3-319-45096-4_1.
   PubMedGoogle Scholar