Cheese and Cardiovascular Disease Risk: A Review of the Evidence and Discussion of Possible Mechanisms

REFERENCES

• Agerbaek, M., Gerdes, L. U. and Richelsen, B. (1995). Hypocholesterolaemic effect of a new fermented milk product in healthy middle-aged men. Eur. J. Clin. Nutr. 49:346–352
   PubMed Web of Science ®Google Scholar
• Agerholm-Larsen, L., Raben, A., Haulrik, N., Hansen, A., Manders, M. and Astrup, A. (2000a). Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur. J. Clin. Nutr. 54:288–297
   PubMed Web of Science ®Google Scholar
• Agerholm-Larsen, L., Bell, M. L., Grunwald, G. K. and Astrup, A. (2000b). The effect of a probiotic milk product on plasma cholesterol: a meta-analysis of short-term intervention studies. Eur. J. Clin. Nutr. 54:856–860
   PubMed Web of Science ®Google Scholar
• Al-Delaimy, W. K., Rimm, E., Willet, W. C., Stampfer, M. J. and Hu, F. B. (2003). A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men. Am. J. Clin. Nutr. 77:814–818
   PubMed Web of Science ®Google Scholar
• Appleby, P. N., Thorogood, M., Mann, J. I. and Key, T. J. (1999). The Oxford Vegetarian Study: an overview. Am. J. Clin. Nutr. 70:525S–531S
   PubMed Web of Science ®Google Scholar
• Artaud-Wild, S. M., Connor, S. L., Sexton, G. and Connor, W. E. (1993). Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. A paradox. Circulation 88:2771–2779
   PubMed Web of Science ®Google Scholar
• Asato, L., Wang, M. F., Chan, Y. C., Yeh, S. H., Chung, H. M., Chung, S. Y., Chida, S., Uezato, T., Suzuki, I., Yamagata, N., Kokubu, T. and Yamamoto, S. (1996). Effect of egg white on serum cholesterol concentration in young women. J. Nutr. Sci. Vitaminol. (Tokyo) 42:87–96
   PubMed Web of Science ®Google Scholar
• Bernstein, A. M., Pan, A., Rexrode, K. M., Stampfer, M., Hu, F. B., Mozaffarian, D. and Willett, W. C. (2012). Dietary protein sources and the risk of stroke in men and women. Stroke 43:637–644
   PubMed Web of Science ®Google Scholar
• Biong, A. S., Muller, H., Sejleflot, I., Veierod, M. B. and Pedersen, J. I. (2004). A comparison of the effects of cheese and butter on serum lipids, haemostatic variables and homocysteine. Br. J. Nutr. 92:791–797
   PubMed Web of Science ®Google Scholar
• Biong, A. S., Rebnord, H. M., Fimreite, R. L., Trygg, K. U., Ringstad, J., Thelle, D. S. and Pedersen, J. I. (2008). Intake of dairy fat and dairy products and risk of myocardial infarction. Int. J. Food Sci. Nutr. 59:155–165
   PubMed Web of Science ®Google Scholar
• Bolland, M. J., Barber, P. A., Doughty, R. N., Mason, B., Horne, A., Ames, R., Gamble, G. D., Grey, A. and Reid, I. R. (2008). Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. Br. Med. J. 336:262–266
   PubMed Web of Science ®Google Scholar
• Bonthuis, M., Hughes, M.C.B., Ibiebele, T. I., Green, A. C. and van der Pols, J. C. (2010). Dairy consumption and patterns of mortality of Australian adults. Eur. J. Clin. Nutr. 64:569–577
   PubMed Web of Science ®Google Scholar
• Boon, N., Hul, G. B., Stegen, J. H., Sluijsmans, W. E., Valle, C., Langin, D., Viguerie, N. and Saris, W. H. (2007). An intervention study of the effects of calcium intake on faecal fat excretion, energy metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins. Int. J. Obes. (Lond) 31:1704–1712
   PubMed Web of Science ®Google Scholar
• Boutrou, R. and Gueguen, M. (2005). Interests in Geotrichum candidum for cheese technology. Int. J. Food Microbiol. 102:1–20
   PubMed Web of Science ®Google Scholar
• Campos, H., Blijlevens, E., McNamara, J. R., Ordovas, J. M., Posner, B. M., Wilson, P. W., Castelli, W. P. and Schaefer, E. J. (1992). LDL particle size distribution. Results from the Framingham Offspring Study. Arteriosclerosis Throm. Vasc. Biol. 12:1410–1419
   PubMed Web of Science ®Google Scholar
• Christensen, R., Lorenzen, J. K., Svith, C. R., Bartels, E. M., Melanson, E. L., Saris, W. H., Tremblay, A. and Astrup, A. (2008). Effect of calcium from dairy and dietary supplements on feacal fat excretion: a meta-analysis of randomized controlled trials. Obes. Rev. 10:475–486
   Web of Science ®Google Scholar
• D’Avanzo, B., Negri, E., Nobili, A. and La, V. C. (1995). Frequency of consumption of selected indicator foods and serum cholesterol. GISSI-EFRIM investigators. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto–Epidemiologia dei Fattori di Rischio dell’Infarto Miocardico. Eur. J. Epidemiol. 11:269–274
   PubMed Web of Science ®Google Scholar
• Davis, P. A., Platon, J. F., Gershwin, M. E., Halpern, G. M., Keen, C. L., DiPaolo, D., Alexander, J. and Ziboh, V. A. (1993). A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. Ann. Int. Med. 119:555–559
   PubMed Web of Science ®Google Scholar
• de Oliveira Otto, M. C., Mozaffarian, D., Kromhout, D., Bertoni, A. G., Sibley, C. T., Jacobs, D. R., Jr. and Nettleton, J. A. (2012). Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Am. J. Clin. Nutr. 96:397–404
   PubMed Web of Science ®Google Scholar
• Denke, M. A., Fox, M. M. and Schulte, M. C. (1993). Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J. Nutr. 123:1047–1053
   PubMed Web of Science ®Google Scholar
• Ditscheid, B., Keller, S. and Jahreis, G. (2005). Cholesterol metabolism is affected by calcium phosphate supplementation in humans. J. Nutr. 135:1678–1682
   PubMed Web of Science ®Google Scholar
• Elwood P. C., Pickering J. E., Givens D. I. and Gallacher J. E. (2010). The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: An overview of the evidence. Lipids 45:925–939
   PubMed Web of Science ®Google Scholar
• Engberink, M. F., Hendriksen, M. A., Schouten, E. G., van Rooij, F. J., Hofman, A., Witteman, J. C. and Geleijnse, J. M. (2009). Inverse association between dairy intake and hypertension: the Rotterdam Study. Am. J. Clin. Nutr. 89:1877–1883
   PubMed Web of Science ®Google Scholar
• Everett, D.W. and Auty, M.A.E. (2008). Cheese structure and current methods of analysis. Int. Dairy J. 18:759–773
   Web of Science ®Google Scholar
• Firmesse, O., Alvaro, E., Mogenet, A., Bresson, J.-L., Lemée, R., Ruyet, P. L., Bonhomme, C., Lambert, D., Andrieux, C., Doré, J., Corthier, G., Furet, J.-P. and Rigottier-Gois, L. (2008). Fate and effects of Camembert cheese micro-organisms in the human colonic microbiota of healthy volunteers after regular Camembert consumption. Int. J. Food Microbiol. 125:176–181
   PubMed Web of Science ®Google Scholar
• Friedewald, W., Levy, R. and Fredrickson, D. (1972). Estimation of the concentration of low-denity-lipoprotein cholesterol in plasma without the use of the ultracentrifuge. Clin. Chem. 18:449–502
   PubMed Web of Science ®Google Scholar
• Fukushima, M. and Nakano, M. (1996). Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on cholesterol metabolism in rats fed on a fat- and cholesterol-enriched diet. Br. J. Nutr. 76:857–867
   PubMed Web of Science ®Google Scholar
• Fumeron, F., Lamri, A., Emery, N., Bellili, N., Jaziri, R., Porchay-Balderelli, I., Lantieri, O., Balkau, B. and Marre, M. (2011). Dairy products and the metabolic syndrome in a prospective study, DESIR. J. Am. Coll. Nutr. 30:454S–463S
   PubMed Web of Science ®Google Scholar
• Gartside, P. S., Wang, P. and Glueck, C. J. (1998). Prospective assessment of coronary heart disease risk factors: The NHANES I Epidemiologic Follow-up Study (NHEFS) 16-year follow-up. J. Am. Coll.Nutr. 17(3):263–269
   PubMed Web of Science ®Google Scholar
• Geurts, L., Everard, A., le, R. P., Delzenne, N. M. and Cani, P. D. (2012). Ripened dairy products differentially affect hepatic lipid content and adipose tissue oxidative stress markers in obese and type 2 diabetic mice. J. Agr.Food Chem. 60:2063–2068
   PubMed Web of Science ®Google Scholar
• Goldbohm, R. A., Chorus, A.M.J., Garre, F. G., Schouten, L. J. and van den Brandt, P. A. (2011). Dairy consumption and 10-y total and cardiovascular mortality: a prospective cohort study in the Netherlands. Am. J. Clin. Nutr. 93:615–627
   PubMed Web of Science ®Google Scholar
• Gramenzi, A., Gentile, A., Fasoli, M., Negri, E., Parazzini, F. and La Vecchia, C. (1990). Association between certain foods and risk of acute myocardial infarction in women. Br. Med. J. 300:771–773
   PubMed Web of Science ®Google Scholar
• Hjerpsted, J., Leedo, E. and Tholstrup, T. (2011). Cheese intake in high amounts lowers LDL-cholesterol concentrations compared with butter intake of equal fat content. Am. J. Clin. Nutr. 94:1479–1484
   PubMed Web of Science ®Google Scholar
• Høstmark, A. T., Haug, A., Tomten, S. E., Thelle, D. S. and Mosdøl, A. (2009). Serum HDL cholesterol was positively associated with cheese intake in the Oslo Health Study. J. Food Lipids 16:89–102
   Web of Science ®Google Scholar
• Høstmark, A.T. and Tomten, S. E. (2011). The Oslo health study: cheese intake was negatively associated with the metabolic syndrome. J. Am. Coll.Nutr. 30:182–190
   PubMed Web of Science ®Google Scholar
• Houston, D. K., Driver, K. E., Bush, A. J. and Kritchevsky, S. B. (2008). The association between cheese consumption and cardiovascular risk factos among adults. J. Human Nutr. Diet. 21:129–140
   PubMed Web of Science ®Google Scholar
• Hu, F. B., Stampfer, M. J., Manson, J. E., Ascherio, A., Colditz, G. A., Speizer, F. E., Hennekens, C. H. and Willet, W. C. (1999). Dietary saturated fats and their sources in relation to the risk of coronary heart disease in women. Am. J. Clin. Nutr. 70:1001–1008
   PubMed Web of Science ®Google Scholar
• Huang, Y.-C., Luedecke, L. O. and Schultz, T. D. (1994). Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men. Nutr. Res. 3:373–386
   Web of Science ®Google Scholar
• Inoue, N., Nagao, K., Hirata, J., Wang, Y. M. and Yanagita, T. (2004). Conjugated linoleic acid prevents the development of essential hypertension in spontanously hypertensive rats. Biochem.Biophys. Res. Commun. 323:670–684
   Web of Science ®Google Scholar
• Intorre, F., Foddai, M. S., Azzini, E., Martin, B., Montel, M. C., Catasta, G., Toti, E., Finotti, E., Palomba, L., Venneria, E., Raguzzini, A., Fumagalli, A., Testa, M. F., Rossi, L. and Maiani, G. (2011). Differential effect of cheese fatty acid composition on blood lipid profile and redox status in normolipidemic volunteers: a pilot study. Int. J. Food Sci. Nutr. 62:660–669
   PubMed Web of Science ®Google Scholar
• Iso, H., Stampfer, M. J., Manson, J. E., Rexrode, K., Hennekens, C. H., Colditz, G. A., Speizer, F. E. and Willett, W. C. (1999). Prospective study of calcium, potassium and magnesium intake and risk of stroke in women. Stroke 30:1772–1779
   PubMed Web of Science ®Google Scholar
• Ivey, K. L., Lewis, J. R., Hodgson, J. M., Zhu, K., Dhaliwal, S. S., Thompson, P. L. and Prince, R. L. (2011). Association between yogurt, milk and cheese consumption and common carotid artery intima-media thickness and cardiovascular disease risk factors in elderly women. Am. J. Clin. Nutr. 94:234–239
   PubMed Web of Science ®Google Scholar
• Jacobsen, R., Lorenzen, J. K., Toubro, S., Krog-Mikkelsen, I. and Astrup, A. (2005). Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal excretion. Int. J. Obes. 29:292–301
   PubMed Web of Science ®Google Scholar
• Jacqmain, M., Doucet, E., Despres, J. P., Bouchard, C. and Tremblay, A. (2003). Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am. J. Clin. Nutr. 77:1448–1452
   PubMed Web of Science ®Google Scholar
• Jauhiainen, T., Salo, P., Niittynen, L., Poussa, T. and Korpela, R. (2006). Effects of low-fat hard cheese enriched with plant stanol esters on serum lipids and apolipoprotein B in mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 60:1253–1257
   PubMed Web of Science ®Google Scholar
• Jorde, R. and Bonaa, K. H. (2000). Calcium from dairy products, vitamin D intake, and blood pressure: the Tromso Study. Am. J. Clin. Nutr. 71:1530–1535
   PubMed Web of Science ®Google Scholar
• Kabagambe, E. K., Baylin, A., Siles, X. and Campos, H. (2003). Individual saturated fatty acids and nonfatal acute myocardial infarction in Costa Rica. Eur. J. Clin. Nutr. 57:1447–1457
   PubMed Web of Science ®Google Scholar
• Karvonen, H. M., Tapola, N. S., Uusitupa, M. I. and Sarkkinen, E. S. (2002). The effect of vegetable oil-based cheese on serum total and lipoprotein lipids. Eur. J. Clin. Nutr. 56:1094–1101
   PubMed Web of Science ®Google Scholar
• Kontogianni, M. D., Panagiotakos, D. B., Chrysohoou, C., Pitsavos, C. and Stefanadis, C. (2006). Modelling dairy intake on the development of acute coronary syndromes: the CARDIO2000 study. Eur. J. Cardiovasc. Prevent. Rehabil. 13:791–797
   PubMed Web of Science ®Google Scholar
• Korpela, R., Tuomilehto, J., Hogstrom, P., Seppo, L., Piironen, V., Salo-Vaananen, P., Toivo, J., Lamberg-Allardt, C., Karkkainen, M., Outila, T., Sundvall, J., Vilkkila, S. and Tikkanen, M. J. (2006). Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. Eur. J. Clin. Nutr. 60:633–642
   PubMed Web of Science ®Google Scholar
• Kris-Etherton, P.M. and Yu, S. (1997). Individual fatty acid effects on plasma lipids and lipoproteins: human studies. Am. J. Clin. Nutr. 65:1628S–1644S
   PubMed Web of Science ®Google Scholar
• Kritchevsky, D., Tepper, S. A., Wright, S., Tso, P. and Czarnecki, S. K. (2000). Influence of conjugated linoleic acid (CLA) on establishment an progression of atherosclerosis in rabbits. J. Am. Coll.Nutr. 19:472S–477S
   PubMed Web of Science ®Google Scholar
• Larsson, S. C., Mannisto, S., Virtanen, M. J., Kontto, J., Albanes, D. and Virtamo, J. (2009). Dairy foods and risk of stroke. Epidemiol. 20:355–360
   PubMed Web of Science ®Google Scholar
• Larsson, S. C., Virtamo, J. and Wolk, A. (2012). Dairy consumption and risk of stroke in Swedish women and men. Stroke 43:1775–1780
   PubMed Web of Science ®Google Scholar
• Li, K., Kaaks, R., Linseisen, J. and Rohrmann, S. (2012). Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg). Heart 98:920–925
   PubMed Web of Science ®Google Scholar
• Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., Karanja, N., Lefevre, M., Rudel, L., Sacks, F., Van, H. L., Winston, M. and Wylie-Rosett, J. (2006). Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 114:82–96
   PubMed Web of Science ®Google Scholar
• Lorenzen, J.K. and Astrup, A. (2011). Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet. Br. J. Nutr. 105:1823–1831
   PubMed Web of Science ®Google Scholar
• Maki, K. C., Butteiger, D. N., Rains, T. M., Lawless, A., Reeves, M. S., Schasteen, C. and Krul, E. S. (2010). Effects of soy protein on lipoprotein lipids and fecal bile acid excretion in men and women with moderate hypercholesterolemia. J. Clin. Lipidol., 4, 531–542
   PubMed Web of Science ®Google Scholar
• Mann, J. I., Appleby, P. N., Key, T. J. and Thorogood, M. (1997). Dietary determinants of ischaemic heart disease in health conscious individuals. Heart 78:450–455
   PubMed Web of Science ®Google Scholar
• Meredith, L., Liebman, M. and Graves, K. (1989). Alterations in plasma lipid levels resulting from tofu and cheese consumption in adult women. J. the Am. Coll.Nutr., 8, 573–579
   PubMed Web of Science ®Google Scholar
• Moss, M. and Freed, D. (2003). The cow and the coronary: epidemiology, biochemistry and immunology. Int. J. Cardiol. 87:203–216
   PubMed Web of Science ®Google Scholar
• Musunuru, K., Orho-Melander, M., Caulfield, M. P., Li, S., Salameh, W. A., Reitz, R. E., Berglund, G., Hedblad, B., Engstrom, G., Williams, P. T., Kathiresan, S., Melander, O. and Krauss, R. M. (2009). Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk. Arteriosclerosis Thromb.Vasc. Biol. 29:1975–1980
   PubMed Web of Science ®Google Scholar
• Nestel, P. J., Chronopulos, A. and Cehun, M. (2005). Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 59:1059–1063
   PubMed Web of Science ®Google Scholar
• Nordestgaard, B.G. and Tybjaerg-Hansen, A. (1992). IDL, VLDL, chylomicrons and atherosclerosis. Eur. J. Epidemiol., 8, 92–98
   PubMed Web of Science ®Google Scholar
• O’Leary, D. H., Polak, J. F., Kronmal, R. A., Manolio, T. A., Burke, G. L. and Wolfson, S. K., Jr. (1999). Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. New Engl. J. Med. 340:14–22
   PubMed Web of Science ®Google Scholar
• Panagiotakos, D. B., Pitsavos, C. H., Zampelas, A. D., Chrysohoou, C. A. and Stefanadis, C. I. (2010). Dairy products consumption is associated with decreased levels of inflammatory markers related to cardiovascular disease in apparently healthy adults: the ATTICA study. J. the Am. Coll.Nutr. 29:357–364
   PubMed Web of Science ®Google Scholar
• Perk, J., De, B. G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, W. M., Albus, C., Benlian, P., Boysen, G., Cifkova, R., Deaton, C., Ebrahim, S., Fisher, M., Germano, G., Hobbs, R., Hoes, A., Karadeniz, S., Mezzani, A., Prescott, E., Ryden, L., Scherer, M., Syvanne, M., Op Reimer, W. J., Vrints, C., Wood, D., Zamorano, J. L. and Zannad, F. (2012). European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012) : The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by Representatives of Nine Societies and by Invited Experts). Int. J. Behav. Med. 19:403–488
   PubMed Web of Science ®Google Scholar
• Rajpathak, S. N., Xue, X., Wassertheil-Smoller, S., Van, H. L., Robinson, J. G., Liu, S., Allison, M., Martin, L. W., Ho, G. Y. and Rohan, T. E. (2010). Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women's Health Initiative. Am. J. Clin. Nutr. 91:894–899
   PubMed Web of Science ®Google Scholar
• Ralston, R. A., Lee, J. H., Truby, H., Palermo, C. E. and Walker, K. Z. (2012). A systematic review and meta-analysis of elevated blood pressure and consumption of dairy foods. J. Human Hypertens. 26:3–13
   PubMed Web of Science ®Google Scholar
• Reid, I. R., Ames, R., Mason, B., Bolland, M. J., Bacon, C. J., Reid, H. E., Kyle, C., Gamble, G. D., Grey, A. and Horne, A. (2010). Effects of calcium supplementation on lipids, blood pressure and body composition in healthy older men: a randomized controlled trial. Am. J. Clin. Nutr. 91:131–139
   PubMed Web of Science ®Google Scholar
• Reid, I. R., Mason, B., Horne, A., Ames, R., Clearwater, J., Bava, U., Orr-Walker, B., Wu, F., Evans, M. C. and Gamble, G. D. (2002). Effects of calcium supplementation on serum lipid concentrations in normal older women: a randomized controlled trial. Am. J. Med. 112:343–347
   PubMed Web of Science ®Google Scholar
• Renaud, S. and de Lorgeril, M. (1989). Dietary lipids and their relation to ischaemic heart disease: from epidemiology to prevention. J. Int. Med.. Suppl. 731:39–46
   PubMedGoogle Scholar
• Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M., Wun, C. C., Davis, B. R. and Braunwald, E. (1996). The effect of pravastatin on coronary events after myocardial infarction in patients with averaginvestigatorse cholesterol levels. Cholesterol and Recurrent Events Trial. New Engl.J. Med. 335:1001–1009
   PubMed Web of Science ®Google Scholar
• Sacks, F.M. and Willett, W. W. (1991). More on chewing the fat. The good fat and the good cholesterol. New Engl. J. Med. 325:1740–1742
   PubMed Web of Science ®Google Scholar
• Samuelson, G., Bratteby, L. E., Moshen, R. and Vessby, B. (2001). Dietary fat intake in healthy adolescents: inverse relationships between the estimated intake of saturated fatty acids and serum cholesterol. Br. J. Nutr. 85:333–341
   PubMed Web of Science ®Google Scholar
• Seely, S. (1988). Diet and coronary arterial disease: a statistical study. Int. J. Cardiol. 20:183–192
   PubMed Web of Science ®Google Scholar
• Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., MacFarlane, P. W., McKillop, J. H. and Packard, C. J. (1995). Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. New Engl. J. Med. 333:1301–1307
   PubMed Web of Science ®Google Scholar
• Sieber, R., Collomb, M., Aeschlimann, A., Jelen, P. and Eyer, H. (2004). Impact of microbial cultures on conjugated linoleic acid in dairy products - a review. Int. Dairy J. 14:1–15
   Web of Science ®Google Scholar
• Siri-Tarino, P. W., Sun, Q., Hu, F. B. and Krauss, R. M. (2010). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am. J. Clin. Nutr. 91:535–545
   PubMed Web of Science ®Google Scholar
• Sjogren, P., Rosell, M., Skoglund-Andersson, C., Zdravkovic, S., Vessby, B., de, F. U., Hamsten, A., Hellenius, M. L. and Fisher, R. M. (2004). Milk-derived fatty acids are associated with a more favorable LDL particle size distribution in healthy men. J. Nutr. 134:1729–1735
   PubMed Web of Science ®Google Scholar
• Snijder, M. B., van der Heijden, A. A., van Dam, R. M., Stehouwer, C. D., Hiddink, G. J., Nijpels, G., Heine, R. J., Bouter, L. M. and Dekker, J. M. (2007). Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study. Am. J. Clin. Nutr. 85:989–995
   PubMed Web of Science ®Google Scholar
• Snowdon, D. A., Phillips, R. L. and Fraser, G. E. (1984). Meat consumption and fatal ischemic heart disease. Prev. Med. J. 13:490–500
   PubMed Web of Science ®Google Scholar
• Soedamah-Muthu, S. S., Verberne, L. D., Ding, E. L., Engberink, M. F. and Geleijnse, J. M. (2012). Dairy Consumption and Incidence of Hypertension: A Dose-Response Meta-Analysis of Prospective Cohort Studies. Hypertension 60:1131–1137
   PubMed Web of Science ®Google Scholar
• Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Abbate, R. and Antongiovanni, M. (2010). Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: a dietary intervention study. Nutr., Metab.Cardiovasc. Dis.J. 20:117–124
   PubMed Web of Science ®Google Scholar
• Sonestedt, E., Wirfalt, E., Wallstrom, P., Gullberg, B., Orho-Melander, M. and Hedblad, B. (2011). Dairy products and its association with incidence of cardiovascular disease: the Malmo diet and cancer cohort. Eur. J. Epidemiol. 26:609–618
   PubMed Web of Science ®Google Scholar
• St-Onge, M. P., Farnworth, E. R. and Jones, P. J. (2000). Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism. Am. J. Clin. Nutr. 71:674–681
   PubMed Web of Science ®Google Scholar
• St-Pierre, A. C., Cantin, B., Dagenais, G. R., Mauriege, P., Bernard, P. M., Despres, J. P. and Lamarche, B. (2005). Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular Study. Arteriosclerosis Thromb.Vasc. Biol. 25:553–559
   PubMed Web of Science ®Google Scholar
• Tavani, A., Gallus, S., Negri, E. and La Vecchia, C. (2002). Milk, dairy products and coronary heart disease. J. Epidemiol. Commun. Health 56:471–472
   PubMed Web of Science ®Google Scholar
• Terpstra, A. H. (2004). Dietary conjugated linloeic acid on body composition and plasma lipids in humans: an overview of the litterature. Am. J. Clin. Nutr. 79:352–361
   PubMed Web of Science ®Google Scholar
• Tholstrup, T. (2006). Dairy products and cardiovascular disease. Curr. Opin. Lipidol. 17:1–10
   PubMed Web of Science ®Google Scholar
• Tholstrup, T., Hoy, C. E., Andersen, L. N., Christensen, R.D.K. and Sandstrom, B. (2004). Does fat in milk, butter and cheese affect blood lipids and cholesterol differently? J. Am. Coll.Nutr. 23:169–176
   PubMed Web of Science ®Google Scholar
• Tricon, S., Burdge, G. C., Jones, E. L., Russell, J. J., El-Khazen, S., Moretti, E., Hall, W. L., Gerry, A. B., Leake, D. S., Grimble, R. F., Williams, C. M., Calder, P. C. and Yaqoob, P. (2006). The effect of vegetable oil-based cheese on serum total and lipoprotein lipids. Am. J. Clin. Nutr. 83:744–753
   PubMed Web of Science ®Google Scholar
• Van der Meer, R., Welberg, J. W., Kuipers, F., Kleibeuker, J. H., Mulder, N. H., Termont, D. S., Vonk, R. J., De Vries, H. T. and De Vries, E. G. (1990). Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate and bile acids. Gastroenterology. 99:1653–1659
   PubMed Web of Science ®Google Scholar
• van Mierlo, L. A., Arends, L. R., Streppel, M. T., Zeegers, M. P., Kok, F. J., Grobbee, D. E. and Geleijnse, J. M. (2006). Blood pressure response to calcium supplementation: a meta-analysis of randomized controlled trials. J. Human Hypertens. 20:571–580
   PubMed Web of Science ®Google Scholar
• von Lossonczy, T. O., Ruiter, A., Bronsgeest-Schoute, H. C., van Gent, C. M. and Hermus, R. J. (1978). The effect of a fish diet on serum lipids in healthy human subjects. Am. J. Clin. Nutr. 31:1340–1346
   PubMed Web of Science ®Google Scholar
• Walther, B., Schmid, A., Sieber, R. and Wehrmüller, K. (2008). Cheese in nutrition and health. Dairy Sci. Technol. 88:389–405
   Web of Science ®Google Scholar
• Warensjö, E., Jansson, J.-H., Cederholm, T., Boman, K., Eliasson, M., Hallmans, G., Johansson, I. and Sjögren, P. (2010). Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study. Am. J. Clin. Nutr. 92:194–202
   PubMed Web of Science ®Google Scholar
• WHO  2012, Cardiovascular diseases (CVDs). Accessed 1–10-2012.
   Google Scholar
• Wolever, T.M.S., Fernandes, J. and Rao, A. V. (1996). Serum acetate:propionate ratio is related to serum choleserol in men but not women. J. Nutr. 126:2790–2797
   PubMed Web of Science ®Google Scholar
• Wolever, T.M.S., Spadafora, P. and Eshuis, H. (1991). Interaction between colonic acetate and propionate in humans. Am. J. Clin. Nutr. 53:681–687
   PubMed Web of Science ®Google Scholar
• Yuangklang, C., Wensing, Th., Lankhorst, Æ., Lemmens, A. G., Fielmich-Bouman, X. M., Jittakhot, S. and Beynen, A. C. (2005). Cholate and deoxycholate counteract the calcium-induced lowering of fat digestion in rats. J. An. Physiol.An. Nutr. 89:337–341
   PubMed Web of Science ®Google Scholar