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Trace minerals intake: Risks and benefits for cardiovascular health

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References

  • Aburto, N. J., S. Hanson, H. Gutierrez, L. Hooper, P. Elliott, and F. P. Cappuccio. 2013. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. Bmj (Clinical Research Ed.) 346:f1378.
  • Afridi, H. I., T. G. Kazi, N. Kazi, F. N. Talpur, Naeemullah, S. S. Arain, K. D. Brahman, S. K. Wadhwa, and F. Shah. 2013. Distribution of copper, iron, and zinc in biological samples of Pakistani hypertensive patients and referent subjects of different age groups. Clinica Y Laboratorio 59:959–67.
  • Ahn, B. I., M. J. Kim, H. S. Koo, N. Seo, N. S. Joo, and Y. S. Kim. 2014. Serum zinc concentration is inversely associated with insulin resistance but not related with metabolic syndrome in nondiabetic Korean adults. Biological Trace Element Research 160:169–75.
  • Al-Bayati, M. A., D. A. Jamil, and H. A. Al-Aubaidy. 2015. Cardiovascular effects of copper deficiency on activity of superoxide dismutase in diabetic nephropathy. North American Journal of Medical Sciences 7:41–46.
  • Alehagen, U., P. Johansson, M. Bjornstedt, A. Rosen, C. Post, and J. Aaseth. 2016. Relatively high mortality risk in elderly Swedish subjects with low selenium status. European Journal of Clinical Nutrition 70:91–96.
  • Alexanian, I., J. Parissis, D. Farmakis, S. Athanaselis, L. Pappas, G. Gavrielatos, C. Mihas, I. Paraskevaidis, A. Sideris, D. Kremastinos, C. Spiliopoulou, M. Anastasiou-Nana, J. Lekakis, and G. Filippatos. 2014. Clinical and echocardiographic correlates of serum copper and zinc in acute and chronic heart failure. Clinical Research in Cardiology 103:938–49.
  • Alexanian, I., J. Parissis, D. Farmakis, C. Pantziou, I. Ikonomidis, I. Paraskevaidis, S. Ioannidou, A. Sideris, D. Kremastinos, J. Lekakis, and G. Filippatos. 2014. Selenium contributes to myocardial injury and cardiac remodeling in heart failure. International Journal of Cardiology 176:272–3.
  • Aliabadi, H. 2008. A deleterious interaction between copper deficiency and sugar ingestion may be the missing link in heart disease. Medical Hypotheses 70:1163–6.
  • Altekin, E., C. Coker, A. R. Sisman, B. Onvural, F. Kuralay, and O. Kirimli. 2005. The relationship between trace elements and cardiac markers in acute coronary syndromes. Journal of Trace Elements in Medicine and Biology 18:235–42.
  • Arnaud, J., T. N. Akbaraly, I. Hininger-Favier, C. Berr, and A. M. Roussel. 2009. Fibrates but not statins increase plasma selenium in dyslipidemic aged patients–the EVA study. Journal of Trace Elements in Medicine and Biology 23:21–28.
  • Arora, N. P., and J. K. Ghali. 2013. Iron deficiency anemia in heart failure. Heart Failure Reviews 18:485–501.
  • Baggott, J. E., and T. Tamura. 2015. Homocysteine, iron and cardiovascular disease: a hypothesis. Nutrients 7:1108–18.
  • Bao, B., A. S. Prasad, F. W. Beck, J. T. Fitzgerald, D. Snell, G. W. Bao, T. Singh, and L. J. Cardozo. 2010. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. American Journal of Clinical Nutrition 91:1634–41.
  • Bayir, A., H. Kara, A. Kiyici, B. Ozturk, and F. Akyurek. 2013. Levels of selenium, zinc, copper, and cardiac troponin I in serum of patients with acute coronary syndrome. Biological Trace Element Research 154:352–6.
  • Bleys, J., A. Navas-Acien, and E. Guallar. 2008. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Archives of Internal Medicine 168:404–10.
  • Bo, S., M. Durazzo, R. Gambino, C. Berutti, N. Milanesio, A. Caropreso, L. Gentile, M. Cassader, P. Cavallo-Perin, and G. Pagano. 2008. Associations of dietary and serum copper with inflammation, oxidative stress, and metabolic variables in adults. Journal of Nutrition 138:305–10.
  • Boosalis, M. G. 2008. The role of selenium in chronic disease. Nutrition in Clinical Practice 23:152–60.
  • Bost, M., S. Houdart, M. Oberli, E. Kalonji, J. F. Huneau, and I. Margaritis. 2016. Dietary copper and human health: Current evidence and unresolved issues. Journal of Trace Elements in Medicine and Biology 35:107–15.
  • Brayer, K. J., and D. J. Segal. 2008. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Cell Biochemistry and Biophysics 50:111–31.
  • Brown, K. M., and J. R. Arthur. 2001. Selenium, selenoproteins and human health: a review. Public Health Nutrition 4:593–9.
  • Cabassi, A., S. M. Binno, S. Tedeschi, V. Ruzicka, S. Dancelli, R. Rocco, V. Vicini, P. Coghi, G. Regolisti, A. Montanari, E. Fiaccadori, P. Govoni, M. Piepoli, and J. de Champlain. 2014. Low serum ferroxidase I activity is associated with mortality in heart failure and related to both peroxynitrite-induced cysteine oxidation and tyrosine nitration of ceruloplasmin. Circulation Research 114:1723–32.
  • Chang, Y. L., S. H. Hung, W. Ling, H. C. Lin, H. C. Li, and S. D. Chung. 2013. Association between ischemic stroke and iron-deficiency anemia: a population-based study. PLoS One 8:e82952.
  • Chen, A., G. Li, and Y. Liu. 2015. Association between copper levels and myocardial infarction: a meta-analysis. Inhalation Toxicology 27:237–46.
  • Chrysant, S. G., and G. S. Chrysant. 2014. Controversy regarding the association of high calcium intake and increased risk for cardiovascular disease. The Journal of Clinical Hypertension (Greenwich) 16:545–50.
  • Chu, A., M. Foster, and S. Samman. 2016. Zinc Status and Risk of Cardiovascular Diseases and Type 2 Diabetes Mellitus-A Systematic Review of Prospective Cohort Studies. Nutrients 8.
  • Cotroneo, E., A. Ashek, L. Wang, J. Wharton, O. Dubois, S. Bozorgi, M. Busbridge, K. N. Alavian, M. R. Wilkins, and L. Zhao. 2015. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circulation Research 116:1680–90.
  • Danesh, J., and P. Appleby. 1999. Coronary heart disease and iron status: meta-analyses of prospective studies. Circulation 99:852–4.
  • Das De, S., S. Krishna, and A. Jethwa. 2015. Iron status and its association with coronary heart disease: systematic review and meta-analysis of prospective studies. Atherosclerosis 238:296–303.
  • Davydenko, N. V., I. P. Smirnova, E. A. Kvasha, I. M. Gorbas, and A. V. Koblianskaia. 1995. [Interrelationship between dietary intake of minerals and prevalence of hypertension]. Voprosy Pitaniia 6:17–19.
  • de Lorgeril, M., and P. Salen. 2006. Selenium and antioxidant defenses as major mediators in the development of chronic heart failure. Heart Failure Reviews 11:13–17.
  • De Paula, R. C., E. C. Aneni, A. P. Costa, V. N. Figueiredo, F. A. Moura, W. M. Freitas, L. A. Quaglia, S. N. Santos, A. A. Soares, W. Nadruz, Jr., M. Blaha, R. Blumenthal, A. Agatston, K. Nasir, and A. C. Sposito. 2014. Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly. BBA Clinical 2:1–6.
  • DiSilvestro, R. A., E. L. Joseph, W. Zhang, A. E. Raimo, and Y. M. Kim. 2012. A randomized trial of copper supplementation effects on blood copper enzyme activities and parameters related to cardiovascular health. Metabolism 61:1242–6.
  • Drozd, M., E. A. Jankowska, W. Banasiak, and P. Ponikowski. 2017. Iron Therapy in Patients with Heart Failure and Iron Deficiency: Review of Iron Preparations for Practitioners. American Journal of Cardiovascular Drugs 17:183–201.
  • Duncan, C., and A. R. White. 2012. Copper complexes as therapeutic agents. Metallomics 4:127–38.
  • Elwood, P., J. Galante, J. Pickering, S. Palmer, A. Bayer, Y. Ben-Shlomo, M. Longley, and J. Gallacher. 2013. Healthy lifestyles reduce the incidence of chronic diseases and dementia: evidence from the Caerphilly cohort study. PloS One 8:e81877.
  • Eshak, E. S., H. Iso, K. Maruyama, I. Muraki, and A. Tamakoshi. 2017. Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus: A large population-based prospective cohort study. Clinical Nutrition
  • Flores-Mateo, G., A. Navas-Acien, R. Pastor-Barriuso, and E. Guallar. 2006. Selenium and coronary heart disease: a meta-analysis. American Journal of Clinical Nutrition 84:762–73.
  • Fortmann, S. P., B. U. Burda, C. A. Senger, J. S. Lin, and E. P. Whitlock. 2013. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force. Annals of Internal Medicine 159:824–34.
  • Foster, M., P. Petocz, and S. Samman. 2010. Effects of zinc on plasma lipoprotein cholesterol concentrations in humans: a meta-analysis of randomised controlled trials. Atherosclerosis 210:344–52.
  • Foster, M., and S. Samman. 2012. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients 4:676–94.
  • Friedrich, N., N. Milman, H. Volzke, A. Linneberg, and T. Jorgensen. 2009. Is serum ferritin within the reference range a risk predictor of cardiovascular disease? A population-based, long-term study comprising 2874 subjects. British Journal of Nutrition 102:594–600.
  • Fryer, M. J. 2002. Rationale for clinical trials of selenium as an antioxidant for the treatment of the cardiomyopathy of Friedreich's ataxia. Medical Hypotheses 58:127–32.
  • Galan, P., A. C. Vergnaud, I. Tzoulaki, J. F. Buyck, J. Blacher, S. Czernichow, and S. Hercberg. 2010. Low total and nonheme iron intakes are associated with a greater risk of hypertension. Journal of Nutrition 140:75–80.
  • Galhardi, C. M., Y. S. Diniz, L. A. Faine, H. G. Rodrigues, R. C. Burneiko, B. O. Ribas, and E. L. Novelli. 2004. Toxicity of copper intake: lipid profile, oxidative stress and susceptibility to renal dysfunction. Food and Chemical Toxicology 42:2053–60.
  • Ganz, T., and E. Nemeth. 2006. Iron imports. IV. Hepcidin and regulation of body iron metabolism. American journal of physiology Gastrointestinal and liver physiology 290:G199–203.
  • Ganz, T., and E. Nemeth. 2012. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harbor Perspectives in Medicine 2:a011668.
  • Ghaemian, A., E. Salehifar, R. Jalalian, F. Ghasemi, S. Azizi, S. Masoumi, H. Shiraj, R. A. Mohammadpour, and G. A. Bagheri. 2011. Zinc and copper levels in severe heart failure and the effects of atrial fibrillation on the zinc and copper status. Biological Trace Element Research 143:1239–46.
  • Ghayour-Mobarhan, M., A. Shapouri-Moghaddam, M. Azimi-Nezhad, H. Esmaeili, S. M. Parizadeh, M. Safarian, S. M. Kazemi-Bajestani, G. H. Khodaei, S. J. Hosseini, S. M. Parizadeh, and G. A. Ferns. 2009. The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian cohort. Journal of Trace Elements in Medicine and Biology 23:167–75.
  • Ghayour-Mobarhan, M., A. Taylor, S. A. New, D. J. Lamb, and G. A. Ferns. 2005. Determinants of serum copper, zinc and selenium in healthy subjects. Annals of Clinical Biochemistry 42:364–75.
  • Giannoglou, G. D., D. M. Konstantinou, L. Kovatsi, Y. S. Chatzizisis, and D. P. Mikhailidis. 2010. Association of reduced zinc status with angiographically severe coronary atherosclerosis: a pilot study. Angiology. 61:449–55.
  • Grammer, T. B., M. E. Kleber, G. Silbernagel, S. Pilz, H. Scharnagl, E. Lerchbaum, A. Tomaschitz, W. Koenig, and W. Marz. 2014. Copper, ceruloplasmin, and long-term cardiovascular and total mortality (the Ludwigshafen Risk and Cardiovascular Health Study. Free Radical Research 48:706–15.
  • Groenveld, H. F., J. L. Januzzi, K. Damman, J. van Wijngaarden, H. L. Hillege, D. J. van Veldhuisen, and P. van der Meer. 2008. Anemia and mortality in heart failure patients a systematic review and meta-analysis. Journal of the American College of Cardiology 52:818–27.
  • Gudjoncik, A., C. Guenancia, M. Zeller, Y. Cottin, C. Vergely, and L. Rochette. 2014. Iron, oxidative stress, and redox signaling in the cardiovascular system. Molecular Nutrition & Food Research 58:1721–38.
  • Hammadah, M., Y. Fan, Y. Wu, S. L. Hazen, and W. H. Tang. 2014. Prognostic value of elevated serum ceruloplasmin levels in patients with heart failure. Journal of Cardiac Failure 20:946–52.
  • Hashemian, M., H. Poustchi, F. Mohammadi-Nasrabadi, and A. Hekmatdoost. 2015. Systematic review of zinc biochemical indicators and risk of coronary heart disease. ARYA Atheroscler 11:357–65.
  • Henrotte, J. G., M. Santarromana, G. Franck, P. Guicheney, R. Boulu, and R. Bourdon. 1992. High cardiac zinc levels in spontaneously hypertensive rats. Journal of Hypertension 10:553–9.
  • Hercberg, S., S. Bertrais, S. Czernichow, N. Noisette, P. Galan, A. Jaouen, J. Tichet, S. Briancon, A. Favier, L. Mennen, and A. M. Roussel. 2005. Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX Study. Lipids 40:335–42.
  • Hosseini, B., A. Saedisomeolia, and M. R. Skilton. 2017. Association between Micronutrients Intake/Status and Carotid Intima Media Thickness: A Systematic Review. Journal of the Academy of Nutrition and Dietetics 117:69–82.
  • Hu, X. F., K. M. Eccles, and H. M. Chan. 2017. High selenium exposure lowers the odds ratios for hypertension, stroke, and myocardial infarction associated with mercury exposure among Inuit in Canada. Environment International 102:200–06.
  • Huang, L., T. Teng, B. Bian, W. Yao, X. Yu, Z. Wang, Z. Xu, and Y. Sun. 2017. Zinc Levels in Left Ventricular Hypertrophy. Biological Trace Element Research 176:48–55.
  • Hunnicutt, J., K. He, and P. Xun. 2014. Dietary iron intake and body iron stores are associated with risk of coronary heart disease in a meta-analysis of prospective cohort studies. Journal of Nutrition 144:359–66.
  • Islamoglu, Y., O. Evliyaoglu, E. Tekbas, H. Cil, M. A. Elbey, Z. Atilgan, H. Kaya, Z. Bilik, A. Akyuz, and S. Alan. 2011. The relationship between serum levels of Zn and Cu and severity of coronary atherosclerosis. Biological Trace Element Research 144:436–444.
  • Jankowska, E. A., M. Tkaczyszyn, T. Suchocki, M. Drozd, S. von Haehling, W. Doehner, W. Banasiak, G. Filippatos, S. D. Anker, and P. Ponikowski. 2016. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. European Journal of Heart Failure 18:786–795.
  • Jankowska, E. A., S. von Haehling, S. D. Anker, I. C. Macdougall, and P. Ponikowski. 2013. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. European Heart Journal 34:816–829.
  • Jelani, Q. U., and S. D. Katz. 2010. Iron in heart failure: friend or foe? Current Heart Failure Reports 7:49–51.
  • Joseph, J., and J. Loscalzo. 2013. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients 5:340–358.
  • Ju, W., Li, X., Li, Z., Wu, G. R., Fu, X. F., Yang X. M., Zhang, X. Q., Gao, X. B. 2017) The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials. Journal of Trace Elements in Medicine and Biology 44:8–16.
  • Jurowski, K., B. Szewczyk, G. Nowak, and W. Piekoszewski. 2014. Biological consequences of zinc deficiency in the pathomechanisms of selected diseases. Journal of Biological Inorganic Chemistry 19:1069–79.
  • Kang, B. P., U. Mehta, and M. P. Bansal. 1997. Effect of diet induced hypercholesterolemia and selenium supplementation on nitric oxide synthase activity. Archives of Physiology and Biochemistry 105:603–06.
  • Kang, Y. J. 2011. Copper and homocysteine in cardiovascular diseases. Pharmacology &Amp; Therapeutics 129:321–31.
  • Karagulova, G., Y. Yue, A. Moreyra, M. Boutjdir, and I. Korichneva. 2007. Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms. Journal of Pharmacology and Experimental Therapeutics 321:517–25.
  • Kim, J. 2013. Dietary zinc intake is inversely associated with systolic blood pressure in young obese women. Nutrition Research and Practice 7:380–4.
  • Kim, M. K., K. H. Baek, K. H. Song, M. I. Kang, J. H. Choi, J. C. Bae, C. Y. Park, W. Y. Lee, and K. W. Oh. 2012. Increased serum ferritin predicts the development of hypertension among middle-aged men. American Journal of Hypertension 25:492–7.
  • Klevay, L. M. 2000. Cardiovascular disease from copper deficiency–a history. Journal of Nutrition 130:489s–492s.
  • Klip, I. T., Comin-Colet, J., Voors, A. A., Ponikowski, P., Enjuanes, C., Banasiak, W., Lok, D. J., Rosentryt, P., Torrens, A., Polonski, L., van Veldhuisen, D. J., van der Meer, P., Jankowska, E. A. 2013) Iron deficiency in chronic heart failure: an international pooled analysis. American Heart Journal 165, 575–82 e573.
  • Kolte, D., K. Vijayaraghavan, S. Khera, D. A. Sica, and W. H. Frishman. 2014. Role of magnesium in cardiovascular diseases. Cardiology in Review 22:182–92.
  • Kunutsor, S. K., and J. A. Laukkanen. 2016. Serum zinc concentrations and incident hypertension: new findings from a population-based cohort study. Journal of Hypertension 34:1055–61.
  • Laclaustra, M., A. Navas-Acien, S. Stranges, J. M. Ordovas, and E. Guallar. 2009. Serum selenium concentrations and hypertension in the US Population. Circulation: Cardiovascular Quality and Outcomes 2:369–76.
  • Laclaustra, M., S. Stranges, A. Navas-Acien, J. M. Ordovas, and E. Guallar. 2010. Serum selenium and serum lipids in US adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004. Atherosclerosis 210:643–8.
  • Lapice, E., M. Masulli, and O. Vaccaro. 2013. Iron deficiency and cardiovascular disease: an updated review of the evidence. Current Atherosclerosis Reports 15:358.
  • Lian, J., L. Xu, Y. Huang, Y. Le, D. Jiang, X. Yang, W. Xu, X. Huang, C. Dong, M. Ye, J. Zhou, and S. Duan. 2013. Meta-analyses of HFE variants in coronary heart disease. Gene 527:167–73.
  • Little, P. J., R. Bhattacharya, A. E. Moreyra, and I. L. Korichneva. 2010. Zinc and cardiovascular disease. Nutrition (Burbank, Los Angeles County, Calif.) 26:1050–7.
  • Liu, H., H. Xu, and K. Huang. 2017. Selenium in the prevention of atherosclerosis and its underlying mechanisms. Metallomics 9:21–37.
  • Livingstone, C. 2015. Zinc: physiology, deficiency, and parenteral nutrition. Nutrition in Clinical Practice 30:371–82.
  • Ljungkrantz, M., J. Ludvigsson, and U. Samuelsson. 2008. Type 1 diabetes: increased height and weight gains in early childhood. Pediatric Diabetes 9:50–56.
  • Lutfi, M. F., R. F. Elhakeem, R. S. Khogaly, A. A. Abdrabo, A. B. Ali, G. I. Gasim, and I. Adam. 2015. Zinc and copper levels are not correlated with angiographically-defined coronary artery disease in sudanese patients. Frontiers in Physiology 6:191.
  • Ma, J., and M. J. Stampfer. 2002. Body iron stores and coronary heart disease. Clinical Chemistry 48:601–3.
  • Mainous, A. G., 3rd, E. D. Weinberg, V. A. Diaz, S. P. Johnson, M. M. Hulihan, and A. M. Grant. 2012. Calcium channel blocker use and serum ferritin in adults with hypertension. Biometals 25:563–568.
  • Malavolta, M., R. Giacconi, F. Piacenza, L. Santarelli, C. Cipriano, L. Costarelli, S. Tesei, S. Pierpaoli, A. Basso, R. Galeazzi, F. Lattanzio, and E. Mocchegiani. 2010. Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population. Biogerontology 11:309–319.
  • Marchan, R., C. Cadenas, and H. M. Bolt. 2012. Zinc as a multipurpose trace element. Archives of Toxicology 86:519–520.
  • Mascitelli, L., M. R. Goldstein, and F. Pezzetta. 2011. Explaining sex difference in coronary heart disease: is it time to shift from the oestrogen hypothesis to the iron hypothesis? Journal of Cardiovascular Medicine (Hagerstown) 12:64–65.
  • McDaid, O., B. Stewart-Knox, H. Parr, and E. Simpson. 2007) Dietary zinc intake and sex differences in taste acuity in healthy young adults. Journal of Human Nutrition and Dietetics 20,103–110.
  • Medeiros, D. M. 2017. Perspectives on the Role and Relevance of Copper in Cardiac Disease. Biological Trace Element Research 176:10–19.
  • Meyers, D. G., D. Strickland, P. A. Maloley, J. K. Seburg, J. E. Wilson, and B. F. McManus. 1997. Possible association of a reduction in cardiovascular events with blood donation. Heart 78:188–93.
  • Moyer, V. A., and U. S. P. S. T. Force. 2014. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive services Task Force recommendation statement. Annals of Internal Medicine 160:558–64.
  • Munoz-Bravo, C., M. Gutierrez-Bedmar, J. Gomez-Aracena, A. Garcia-Rodriguez, and J. F. Navajas. 2013. Iron: protector or risk factor for cardiovascular disease? Still controversial. Nutrients 5:2384–404.
  • Munshi, A., S. Babu, S. Kaul, G. Shafi, K. Rajeshwar, S. Alladi, and A. Jyothy. 2010. "Depletion of serum zinc in ischemic stroke patients. Methods and Findings in Experimental and Clinical Pharmacology 32:433–6.
  • Navarro-Alarcon, M., and C. Cabrera-Vique. 2008. Selenium in food and the human body: a review. Science of the Total Environment 400:115–41.
  • Nawrot, T. S., J. A. Staessen, H. A. Roels, E. Den Hond, L. Thijs, R. H. Fagard, A. F. Dominiczak, and H. A. Struijker-Boudier. 2007. Blood pressure and blood selenium: a cross-sectional and longitudinal population study. European Heart Journal 28:628–33.
  • Nunes, J. P., S. Sampaio, A. Cerqueira, Z. Kaya, and N. P. Oliveira. 2015. Anti-troponin I antibodies in renal transplant patients. Revista Portuguesa De Cardiologia 34:85–89.
  • Otten, J. J., J. P. Hellwig, and L. D. e. Meyers. 2006. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: National Academies Press.
  • Panchal, S. K., S. Wanyonyi, and L. Brown. 2017. Selenium, Vanadium, and Chromium as Micronutrients to Improve Metabolic Syndrome. Current Hypertension Reports 19:10.
  • Patel, J. M., and D. A. Edwards. 1988. Vitamin E, membrane order, and antioxidant behavior in lung microsomes and reconstituted lipid vesicles. Toxicology and Applied Pharmacology 96:101–14.
  • Prasad, A. S. 2008. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Experimental Gerontology 43:370–7.
  • Qian, C., B. Wei, J. Ding, H. Wu, and Y. Wang. 2016. The Efficacy and Safety of Iron Supplementation in Patients With Heart Failure and Iron Deficiency: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology 32:151–9.
  • Rajapurkar, M. M., S. V. Shah, S. S. Lele, U. N. Hegde, S. Y. Lensing, K. Gohel, B. Mukhopadhyay, S. Gang, and M. L. Eigenbrodt. 2012. Association of catalytic iron with cardiovascular disease. American Journal of Cardiology 109:438–42.
  • Ralston, J., K. S. Reddy, V. Fuster, and J. Narula. 2016. Cardiovascular Diseases on the Global Agenda: The United Nations High Level Meeting, Sustainable Development Goals, and the Way Forward. Global Heart 11:375–9.
  • Ranasinghe, P., W. S. Wathurapatha, M. H. Ishara, R. Jayawardana, P. Galappatthy, P. Katulanda, and G. R. Constantine. 2015. Effects of Zinc supplementation on serum lipids: a systematic review and meta-analysis. Nutrition & Metabolism 12:26.
  • Ravn-Haren, G., Bügel, S., Krath, B. N., Hoac, T., Stagsted, J., Jørgensen, K., Bresson, J. R., Larsen, E. H., Dragsted, L. O. 2008) A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation. British Journal of Nutrition 99:883–92.
  • Rayman, M. P. 2009. Selenoproteins and human health: insights from epidemiological data. Biochimica et Biophysica Acta 1790:1533–40.
  • Rayman, M. P., S. Stranges, B. A. Griffin, R. Pastor-Barriuso, and E. Guallar. 2011. Effect of supplementation with high-selenium yeast on plasma lipids: a randomized trial. Annals of Internal Medicine 154:656–65.
  • Rees, K., L. Hartley, C. Day, N. Flowers, A. Clarke, and S. Stranges. 2013. Selenium supplementation for the primary prevention of cardiovascular disease. The Cochrane Database of Systematic Reviews Cd009671.
  • Reiterer, G., R. MacDonald, J. D. Browning, J. Morrow, S. V. Matveev, A. Daugherty, E. Smart, M. Toborek, and B. Hennig. 2005. Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice. Journal of Nutrition 135:2114–8.
  • Rhodes, C. J., J. Wharton, L. Howard, J. S. Gibbs, A. Vonk-Noordegraaf, and M. R. Wilkins. 2011. Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target. European Respiratory Journal 38:1453–60.
  • Saari, J. T. 2000. Copper deficiency and cardiovascular disease: role of peroxidation, glycation, and nitration. Canadian Journal of Physiology and Pharmacology 78:848–55.
  • Saliba, W., R. El Fakih, and W. Shaheen. 2010. Heart failure secondary to selenium deficiency, reversible after supplementation. International Journal of Cardiology 141:e26–27.
  • Salonen, J. T., G. Alfthan, J. K. Huttunen, J. Pikkarainen, and P. Puska. 1982. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet 2:175–9.
  • Saltman, P. 1983. Trace elements and blood pressure. Annals of Internal Medicine 98:823–7.
  • Saraon, T., and S. D. Katz. 2016. Targeting Iron Deficiency Anemia in Heart Failure. Progress in Cardiovascular Diseases 58:407–15.
  • Sarmento, R. A., F. M. Silva, G. Sbruzzi, B. D. Schaan, and J. C. Almeida. 2013. Antioxidant micronutrients and cardiovascular risk in patients with diabetes: a systematic review. Arquivos Brasileiros De Cardiologia 101:240–8.
  • Saari, J. T. 2000) Copper deficiency and cardiovascular disease: role of peroxidation, glycation, and nitration. Canadian Journal of Physiology and Pharmacology 78:848–55.
  • Schnabel, R., E. Lubos, C. M. Messow, C. R. Sinning, T. Zeller, P. S. Wild, D. Peetz, D. E. Handy, T. Munzel, J. Loscalzo, K. J. Lackner, and S. Blankenberg. 2008. Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study. American Heart Journal 156:1201. e1201-1211.
  • Schultze, M. O. 1939. The effect of deficiencies in copper and iron on the cytochrome oxidase of rat tissues. Journal of Biological Chemistry 129:729–37.
  • Shokrzadeh, M., A. Ghaemian, E. Salehifar, S. Aliakbari, S. S. Saravi, and P. Ebrahimi. 2009. Serum zinc and copper levels in ischemic cardiomyopathy. Biological Trace Element Research 127:116–23.
  • Smith, T. G., N. P. Talbot, K. L. Dorrington, and P. A. Robbins. 2011. Intravenous iron and pulmonary hypertension in intensive care. Intensive Care Medicine 37:1720.
  • Smith, T. G., N. P. Talbot, C. Privat, M. Rivera-Ch, A. H. Nickol, P. J. Ratcliffe, K. L. Dorrington, F. Leon-Velarde, and P. A. Robbins. 2009. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA 302:1444–50.
  • Smyth, A., M. O'Donnell, A. Mente, and S. Yusuf. 2015. Dietary sodium and cardiovascular disease. Current Hypertension Reports 17:559.
  • Soinio, M., J. Marniemi, M. Laakso, K. Pyorala, S. Lehto, and T. Ronnemaa. 2007. Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care 30:523–8.
  • Sone, Y., T. Kido, T. Ainuki, M. Sonoda, I. Ichi, S. Kodama, H. Sone, K. Kondo, Y. Morita, S. Egawa, K. Kawahara, Y. Otsuka, and Y. Fujiwara. 2013. Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males. Journal of Nutritional Science and Vitaminology (Tokyo) 59:325–35.
  • Spasojevic-Kalimanovska, V., N. Bogavac-Stanojevic, D. Kalimanovska-Ostric, L. Memon, S. Spasic, J. Kotur-Stevuljevic, and Z. Jelic-Ivanovic. 2014. Factor analysis of risk variables associated with iron status in patients with coronary artery disease. Clinical Biochemistry 47:564–9.
  • Stadtman, T. C. 1991. Biosynthesis and function of selenocysteine-containing enzymes. Journal of Biological Chemistry 266:16257–60.
  • Stranges, S., A. Navas-Acien, M. P. Rayman, and E. Guallar. 2010. Selenium status and cardiometabolic health: state of the evidence. Nutrition, Metabolism & Cardiovascular Diseases 20:754–60.
  • Suadicani, P., H. O. Hein, and F. Gyntelberg. 1992. Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males. Atherosclerosis 96:33–42.
  • Sullivan, J. L. 1981. Iron and the sex difference in heart disease risk. Lancet 1:1293–4.
  • Sullivan, J. L. 2007. Macrophage iron, hepcidin, and atherosclerotic plaque stability. Experimental Biology and Medicine (Maywood) 232:1014–20.
  • Sullivan, J. L. 2009. Iron in arterial plaque: modifiable risk factor for atherosclerosis. Biochimica et Biophysica Acta 1790:718–23.
  • Sun, Q., L. Shi, E. B. Rimm, E. L. Giovannucci, F. B. Hu, J. E. Manson, and K. M. Rexrode. 2011. Vitamin D intake and risk of cardiovascular disease in US men and women. American Journal of Clinical Nutrition 94:534–42.
  • Tang, W. H., and G. S. Francis. 2010. The year in heart failure. Journal of the American College of Cardiology 55:688–96.
  • Tomat, A. L., L. Costa Mde, and C. T. Arranz. 2011. Zinc restriction during different periods of life: influence in renal and cardiovascular diseases. Nutrition (Burbank, Los Angeles County, Calif.) 27:392–8.
  • Trumbo, P., A. A. Yates, S. Schlicker, and M. Poos. 2001. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Journal of the American Dietetic Association 101:294–301.
  • Tsuboi, A., M. Terazawa Watanabe, T. Kazumi, and K. Fukuo. 2014. Serum copper, zinc and risk factors for cardiovascular disease in community-living Japanese elderly women. Asia Pacific Journal of Clinical Nutrition 23:239–45.
  • Tzoulaki, I., I. J. Brown, Q. Chan, L. Van Horn, H. Ueshima, L. Zhao, J. Stamler, and P. Elliott. 2008. Relation of iron and red meat intake to blood pressure: cross sectional epidemiological study. Bmj (Clinical Research Ed.) 337:a258.
  • Valenti, L., A. Maloberti, S. Signorini, M. Milano, F. Cesana, F. Cappellini, P. Dongiovanni, M. Porzio, F. Soriano, M. Brambilla, G. Cesana, P. Brambilla, C. Giannattasio, and S. Fargion. 2015. Iron Stores, Hepcidin, and Aortic Stiffness in Individuals with Hypertension. Plos One 10:e0134635.
  • Valenti, L., D. W. Swinkels, L. Burdick, P. Dongiovanni, H. Tjalsma, B. M. Motta, C. Bertelli, E. Fatta, D. Bignamini, R. Rametta, S. Fargion, and A. L. Fracanzani. 2011. Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver disease. Nutrition, Metabolism and Cardiovascular Diseases 21:568–75.
  • Valsala, P., and P. A. Kurup. 1987. Investigations on the mechanism of hypercholesterolemia observed in copper deficiency in rats. Journal of Biosciences 12:137–42.
  • van Empel, V. P., J. Lee, T. J. Williams, and D. M. Kaye. 2014. Iron deficiency in patients with idiopathic pulmonary arterial hypertension. Heart, Lung and Circulation 23:287–92.
  • Vezzoli, G., A. A. Elli, G. Tripodi, G. Bianchi, and E. Carafoli. 1985. Calcium ATPase in erythrocytes of spontaneously hypertensive rats of the Milan strain. Journal of Hypertension 3:645–8.
  • von Haehling, S., E. A. Jankowska, D. J. van Veldhuisen, P. Ponikowski, and S. D. Anker. 2015. Iron deficiency and cardiovascular disease. Nature Reviews Cardiology 12:659–69.
  • von Haehling, S., R. S. von Bardeleben, T. Kramm, Y. Thiermann, M. Niethammer, W. Doehner, S. D. Anker, T. Munzel, E. Mayer, and S. Genth-Zotz. 2010. Inflammation in right ventricular dysfunction due to thromboembolic pulmonary hypertension. International Journal of Cardiology 144:206–11.
  • Vu, T. T., J. C. Fredenburgh, and J. I. Weitz. 2013. Zinc: an important cofactor in haemostasis and thrombosis. Thrombosis and Haemostasis 109:421–30.
  • Waldvogel-Abramowski, S., G. Waeber, C. Gassner, A. Buser, B. M. Frey, B. Favrat, and J. D. Tissot. 2014. Physiology of iron metabolism. Transfusion Medicine and Hemotherapy 41:213–21.
  • Witte, K. K., A. L. Clark, and J. G. Cleland. 2001. Chronic heart failure and micronutrients. Journal of the American College of Cardiology 37:1765–74.
  • Yang, W., B. Li, X. Dong, X. Q. Zhang, Y. Zeng, J. L. Zhou, Y. H. Tang, and J. J. Xu. 2014. Is heme iron intake associated with risk of coronary heart disease? A meta-analysis of prospective studies. European Journal of Nutrition 53:395–400.
  • Yary, T., J. K. Virtanen, A. Ruusunen, T. P. Tuomainen, and S. Voutilainen. 2016. Serum zinc and risk of type 2 diabetes incidence in men: The Kuopio Ischaemic Heart Disease Risk Factor Study. Journal of Trace Elements in Medicine and Biology 33:120–4.
  • Zacharski, L. R., G. Shamayeva, and B. K. Chow. 2011. Effect of controlled reduction of body iron stores on clinical outcomes in peripheral arterial disease. American Heart Journal 162:949–57. e941.
  • Zhang, X., C. Liu, J. Guo, and Y. Song. 2016. Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials. European Journal of Clinical Nutrition 70:162–9.
  • Zhou, Z., W. T. Johnson, and Y. J. Kang. 2009. Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes. Journal of Nutritional Biochemistry 20:621–8.
  • Zou, M. H., C. Shi, and R. A. Cohen. 2002. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. Journal of Clinical Investigation 109:817–26.

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