Prebiotic effects of goji berry in protection against inflammatory bowel disease

References

• Ahmed, I., B. C. Roy, S. A. Khan, S. Septer, and S. Umar. 2016. Microbiome, metabolome and inflammatory bowel disease. Microorganisms 4 (2):20. doi: 10.3390/microorganisms4020020.
   PubMed Web of Science ®Google Scholar
• Al-Sadi, R., J. Engers, and R. Abdulqadir. 2020. Talk about micromanaging! Role of microRNAs in intestinal barrier function. American Journal of Physiology. Gastrointestinal and Liver Physiology 319 (2):G170–4. doi: 10.1152/ajpgi.00214.2020.
   PubMed Web of Science ®Google Scholar
• Altomare, A., L. Putignani, F. Del Chierico, S. Cocca, S. Angeletti, M. Ciccozzi, C. Tripiciano, B. D. Piccola, M. Cicala, and M. P. L. Guarino. 2019. Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota. Digestive and Liver Disease 51 (5):648–56. doi: 10.1016/j.dld.2018.11.021.
   Web of Science ®Google Scholar
• Alves-Santos, A. M., C. S. A. Sugizaki, G. C. Lima, and M. M. V. Naves. 2020. Prebiotic effect of dietary polyphenols: A systematic review. Journal of Functional Foods 74:104169. doi: 10.1016/j.jff.2020.104169.
   Web of Science ®Google Scholar
• Amagase, H. 2008. General toxicity and histological analysis from acute toxicological study of a standardized Lycium barbarum (goji) juice (GoChiTM) in rodents. The FASEB Journal 22 (S2):722. doi: 10.1096/fasebj.22.2_supplement.722.
   Google Scholar
• Amagase, H., and N. R. Farnsworth. 2011. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Research International 44 (7):1702–17. doi: 10.1016/j.foodres.2011.03.027.
   Web of Science ®Google Scholar
• Amagase, H., B. X. Sun, and C. Borek. 2009. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutrition Research 29 (1):19–25. doi: 10.1016/j.nutres.2008.11.005.
   PubMed Web of Science ®Google Scholar
• Ananthakrishnan, A. N., C. N. Bernstein, D. Iliopoulos, A. Macpherson, M. F. Neurath, R. A. R. Ali, S. R. Vavricka, and C. Fiocchi. 2018. Environmental triggers in IBD: A review of progress and evidence. Nature Reviews. Gastroenterology & Hepatology 15 (1):39–49. doi: 10.1038/nrgastro.2017.136.
   PubMed Web of Science ®Google Scholar
• Balish, E., and T. Warner. 2002. Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice. The American Journal of Pathology 160 (6):2253–7. doi: 10.1016/S0002-9440(10)61172-8.
   PubMed Web of Science ®Google Scholar
• Banaszkiewicz, A., J. Kądzielska, A. Gawrońska, H. Pituch, P. Obuch-Woszczatyński, P. Albrecht, G. Młynarczyk, and A. Radzikowski. 2014. Enterotoxigenic Clostridium perfringens infection and pediatric patients with inflammatory bowel disease. Journal of Crohn’s & Colitis 8 (4):276–81. doi: 10.1016/j.crohns.2013.08.018.
   PubMed Web of Science ®Google Scholar
• Baumgart, D. C., and S. R. Carding. 2007. Gastroenterology 1—Inflammatory bowel disease: Cause and immunobiology. Lancet 369 (9573):1627–40. doi: 10.1016/S0140-6736(07)60750-8.
   PubMed Web of Science ®Google Scholar
• Baumgart, D. C., and W. J. Sandborn. 2007. Inflammatory bowel disease: Clinical aspects and established and evolving therapies. Lancet 369 (9573):1641–57. doi: 10.1016/S0140-6736(07)60751-X.
   PubMed Web of Science ®Google Scholar
• Bauset, C., L. Gisbert-Ferrandiz, and J. Cosin-Roger. 2021. Metabolomics as a promising resource identifying potential biomarkers for ­inflammatory bowel disease. Journal of Clinical Medicine 10 (4)25.622. doi: 10.3390/jcm10040:.
   PubMed Web of Science ®Google Scholar
• Benzie, I. F., W. Y. Chung, J. Wang, M. Richelle, and P. Bucheli. 2006. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). British Journal of Nutrition 96 (01):154–60. doi: 10.1079/BJN20061796.
   PubMedGoogle Scholar
• Berry, D., C. Schwab, G. Milinovich, J. Reichert, K. Ben Mahfoudh, T. Decker, M. Engel, B. Hai, E. Hainzl, S. Heider, et al. 2012. Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis. The ISME Journal 6 (11):2091–106. doi: 10.1038/ismej.2012.39.
   PubMed Web of Science ®Google Scholar
• Bertoldi, D., L. Cossignani, F. Blasi, M. Perini, A. Barbero, S. Pianezze, and D. Montesano. 2019. Characterisation and geographical traceability of Italian goji berries. Food Chemistry 275:585–93. doi: 10.1016/j.foodchem.2018.09.098.
   PubMed Web of Science ®Google Scholar
• Bevins, C. L., and N. H. Salzman. 2011. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nature Reviews. Microbiology 9 (5):356–68. doi: 10.1038/nrmicro2546.
   PubMed Web of Science ®Google Scholar
• Bielefeldt, K., B. Davis, and D. G. Binion. 2009. Pain and inflammatory bowel disease. Inflammatory Bowel Diseases 15 (5):778–88. doi: 10.1002/ibd.20848.
   PubMed Web of Science ®Google Scholar
• Bjerrum, J. T., Y. L. Wang, F. H. Hao, M. Coskun, C. Ludwig, U. Gunther, and O. H. Nielsen. 2015. Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals. Metabolomics 11 (1):122–33. doi: 10.1007/s11306-014-0677-3.
   PubMed Web of Science ®Google Scholar
• Bloom, S. M., V. N. Bijanki, G. M. Nava, L. L. Sun, N. P. Malvin, D. L. Donermeyer, W. M. Dunne, P. M. Allen, and T. S. Stappenbeck. 2011. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host & Microbe 9 (5):390–403. doi: 10.1016/j.chom.2011.04.009.
   PubMed Web of Science ®Google Scholar
• Bochimoto, H., D. Kondoh, R. Nagata, Y. Ishihara, J. Tomiyasu, K. H. Han, K. Shimada, M. Sasaki, N. Kitamura, and M. Fukushima. 2019. Ultrastructural changes in colonic epithelial cells in a rat model of inflammatory bowel disease. Microscopy Research and Technique 82 (8):1339–44. doi: 10.1002/jemt.23285.
   PubMed Web of Science ®Google Scholar
• Breithaupt, D. E., P. Weller, M. Wolters, and A. Hahn. 2004. Comparison of plasma responses in human subjects after the ingestion of 3R,3R′-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R′-zeaxanthin using chiral high-performance liquid chromatography. The British Journal of Nutrition 91 (5):707–13. doi: 10.1079/bjn20041105.
   PubMed Web of Science ®Google Scholar
• Brown, E. M., M. Sadarangani, and B. B. Finlay. 2013. The role of the immune system in governing host-microbe interactions in the intestine. Nature Immunology 14 (7):660–7. doi: 10.1038/ni.2611.
   PubMed Web of Science ®Google Scholar
• Bruewer, M., A. Luegering, T. Kucharzik, C. A. Parkos, J. L. Madara, A. M. Hopkins, and A. Nusrat. 2003. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. Journal of Immunology 171 (11):6164–72. doi: 10.4049/jimmunol.171.11.6164.
   PubMed Web of Science ®Google Scholar
• Buchman, A. L., A. M. Babbo, and R. G. Gieser. 2006. Central retinal vein thrombosis in a patient with ulcerative colitis. Digestive Diseases and Sciences 51 (10):1847–9. doi: 10.1007/s10620-006-9188-z.
   PubMed Web of Science ®Google Scholar
• Cai, H., F. Liu, P. Zuo, G. Huang, Z. Song, T. Wang, H. Lu, F. Guo, C. Han, and G. Sun. 2015. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Medicinal Chemistry 11 (4):383–90. doi: 10.2174/1573406410666141110153858.
   PubMed Web of Science ®Google Scholar
• Cao, S. M., J. L. Du, and Q. H. Hei. 2017. Lycium barbarum polysaccharide protects against neurotoxicity via the Nrf2-HO-1 pathway. Experimental and Therapeutic Medicine 14 (5):4919–27. doi: 10.3892/etm.2017.5127.
   PubMed Web of Science ®Google Scholar
• Carbonero, F., A. C. Benefiel, and H. R. Gaskins. 2012. Contributions of the microbial hydrogen economy to colonic homeostasis. Nature Reviews Gastroenterology & Hepatology 9 (9):504–518. doi: 10.1038/nrgastro.2012.85.
   PubMed Web of Science ®Google Scholar
• Caviglia, G. P., F. Dughera, D. G. Ribaldone, C. Rosso, M. L. Abate, R. Pellicano, F. Bresso, A. Smedile, G. M. Saracco, and M. Astegiano. 2019. Serum zonulin in patients with inflammatory bowel disease: A pilot study. Minerva Medica 110 (2):95–100. doi: 10.23736/S0026-4806.18.05787-7.
   PubMed Web of Science ®Google Scholar
• Chan, H. C., R. C. C. Chang, A. K. C. Ip, K. Chiu, W. H. Yuen, S. Y. Zee, and K. F. So. 2007. Neuroprotective effects of Lycium ­barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Experimental Neurology 203 (1):269–73. doi: 10.1016/j.expneurol.2006.05.031.
   PubMed Web of Science ®Google Scholar
• Chan, J. C. N., V. Malik, W. P. Jia, T. Kadowaki, C. S. Yajnik, K. H. Yoon, and F. B. Hu. 2009. Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. JAMA 301 (20):2129–40. doi: 10.1001/jama.2009.726.
   PubMed Web of Science ®Google Scholar
• Chen, G. X., X. Ran, B. Li, Y. H. Li, D. W. He, B. X. Huang, S. P. Fu, J. X. Liu, and W. Wang. 2018. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model. Ebiomedicine 30:317–25. doi: 10.1016/j.ebiom.2018.03.030.
   PubMed Web of Science ®Google Scholar
• Chen, J. L., B. Yu, D. W. Chen, Z. Q. Huang, X. B. Mao, P. Zheng, J. Yu, J. Q. Luo, and J. He. 2018. Chlorogenic acid improves intestinal barrier functions by suppressing mucosa inflammation and improving antioxidant capacity in weaned pigs. The Journal of Nutritional Biochemistry 59:84–92. doi: 10.1016/j.jnutbio.2018.06.005.
   PubMed Web of Science ®Google Scholar
• Chen, J. L., B. Yu, D. W. Chen, P. Zheng, Y. H. Luo, Z. Q. Huang, J. Q. Luo, X. B. Mao, J. Yu, and J. He. 2019. Changes of porcine gut microbiota in response to dietary chlorogenic acid supplementation. Applied Microbiology and Biotechnology 103 (19):8157–68. doi: 10.1007/s00253-019-10025-8.
   PubMed Web of Science ®Google Scholar
• Chen, J. S., L. N. Long, Q. Jiang, B. J. Kang, Y. H. Li, and J. Yin. 2020. Effects of dietary supplementation of Lycium barbarum polysaccharides on growth performance, immune status, antioxidant capacity and selected microbial populations of weaned piglets. Journal of Animal Physiology and Animal Nutrition 104 (4):1106–15. doi: 10.1111/jpn.13247.
   PubMed Web of Science ®Google Scholar
• Chen, L. A., S. K. Hourigan, Z. Grigoryan, Z. Gao, J. C. Clemente, J. R. Rideout, S. Chirumamilla, S. Rabidazeh, S. Saeed, C. O. Elson, et al. 2019. Decreased fecal bacterial diversity and altered microbiome in children colonized with Clostridium difficile. Journal of Pediatric Gastroenterology & Nutrition 68 (4):502–8. doi: 10.1097/MPG.0000000000002210.
   PubMed Web of Science ®Google Scholar
• Chen, L., M. M. Sun, W. Wu, W. J. Yang, X. S. Huang, Y. Xiao, C. Y. Ma, L. Q. Xu, S. X. Yao, Z. J. Liu, et al. 2019. Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells’ differentiation and function in induction of colitis. Inflammatory Bowel Diseases 25 (9):1450–61. doi: 10.1093/ibd/izz046.
   PubMed Web of Science ®Google Scholar
• Chen, W., X. Cheng, J. Chen, X. Yi, D. Nie, X. Sun, J. Qin, M. Tian, G. Jin, and X. Zhang. 2014. Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine-treated rats. PLoS One 9 (2):e88076. doi: 10.1371/journal.pone.0088076.
   PubMed Web of Science ®Google Scholar
• Chen, Z., B. Kwong Huat Tan, and S. H. Chan. 2008. Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L. International Immunopharmacology 8 (12):1663–71. doi: 10.1016/j.intimp.2008.07.019.
   PubMed Web of Science ®Google Scholar
• Cheng, J., E. Balbuena, B. Miller, and A. Eroglu. 2021. The role of β-carotene in colonic inflammation and intestinal barrier integrity. Frontiers in Nutrition 8:660. doi: 10.3389/fnut.2021.723480.
   Web of Science ®Google Scholar
• Cheng, J., Z. W. Zhou, H. P. Sheng, L. J. He, X. W. Fan, Z. X. He, T. Sun, X. Zhang, R. J. Zhao, L. Gu, et al. 2015. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Design, Development and Therapy 9:33–78. doi: 10.2147/DDDT.S72892.
   PubMed Web of Science ®Google Scholar
• Choi, C. H. R., I. Al Bakir, A. L. Hart, and T. A. Graham. 2017. Clonal evolution of colorectal cancer in IBD. Nature Reviews. Gastroenterology & Hepatology 14 (4):218–29. doi: 10.1038/nrgastro.2017.1.
   PubMed Web of Science ®Google Scholar
• Choi, H., C. B. A. Matta, G. Fu, G. Trichonas, M. L. Morgan, M. Yursky, J. Katz, and P. Sinh. 2019. Central retinal vein occlusion: A rare ocular complication of inflammatory bowel disease—A case series. Inflammatory Bowel Diseases 25 (9):E110–1. doi: 10.1093/ibd/izz086.
   PubMed Web of Science ®Google Scholar
• Claesson, M. H., F. Nicoletti, S. Stosic-Grujicic, A. Doria, and S. Zampieri. 2008. Interactions between infections and immune-inflammatory cells in type 1 diabetes mellitus and inflammatory bowel diseases: Evidences from animal models. Clinical and Experimental Rheumatology 26 (1):S8–S11.
   PubMed Web of Science ®Google Scholar
• Crosnier, C., D. Stamataki, and J. Lewis. 2006. Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control. Nature Reviews. Genetics 7 (5):349–59. doi: 10.1038/nrg1840.
   PubMed Web of Science ®Google Scholar
• Cui, B., Y. Chen, S. Liu, J. Wang, S. Li, Q. Wang, S. Li, M. Chen, and X. Lin. 2012. Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats. International Journal of Biological Macromolecules 51 (3):314–8. doi: 10.1016/j.ijbiomac.2012.05.004.
   PubMed Web of Science ®Google Scholar
• Cui, B., S. Liu, X. Lin, J. Wang, S. Li, Q. Wang, and S. Li. 2011. Effects of Lycium barbarum aqueous and ethanol extracts on high-fat-diet induced oxidative stress in rat liver tissue. Molecules 16 (11):9116–28. doi: 10.3390/molecules16119116.
   PubMed Web of Science ®Google Scholar
• Cui, K. R., G. S. Xing, X. M. Liu, G. M. Xing, and Y. F. Wang. 1999. Effect of hydrogen peroxide on somatic embryogenesis of Lycium barbarum L. Plant Science 146 (1):9–16.
   Web of Science ®Google Scholar
• de Alencar, H., A. P. R. Paiotti, H. B. De Araujo, C. T. F. Oshima, S. J. Miszputen, and O. Ambrogini. 2020. The relationship between the commensal microbiota levels and Crohn’s disease activity. JGH Open 4 (5):784–9. doi: 10.1002/jgh3.12338.
   PubMed Web of Science ®Google Scholar
• De Cruz, P., L. Prideaux, J. Wagner, S. C. Ng, C. McSweeney, C. Kirkwood, M. Morrison, and M. A. Kamm. 2012. Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease. Inflammatory Bowel Diseases 18 (2):372–90. doi: 10.1002/ibd.21751.
   PubMed Web of Science ®Google Scholar
• de Meij, T. G. J., E. F. J. de Groot, C. F. W. Peeters, N. K. H. de Boer, C. M. F. Kneepkens, A. Eck, M. A. Benninga, P. H. M. Savelkoul, A. A. van Bodegraven, and A. E. Budding. 2018. Variability of core microbiota in newly diagnosed treatment-naive paediatric inflammatory bowel disease patients. PLoS One 13 (8):e0197649. doi: 10.1371/journal.pone.0197649.
   PubMed Web of Science ®Google Scholar
• de Sousa Moraes, L. F., X. Sun, M. Peluzio, and M. J. Zhu. 2019. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? Critical Reviews in Food Science and Nutrition 59 (1):59–71. doi: 10.1080/10408398.2017.1357533.
   PubMed Web of Science ®Google Scholar
• de Souza, H. S. P., and C. Fiocchi. 2016. Immunopathogenesis of IBD: Current state of the art. Nature Reviews. Gastroenterology & Hepatology 13 (1):13–27. doi:10.1038/nrgastro.2016.186.
   PubMed Web of Science ®Google Scholar
• Dijkstra, G., H. Moshage, H. M. Van Dullemen, A. De Jager-Krikken, A. Tiebosch, J. H. Kleibeuker, P. L. M. Jansen, and H. Van Goor. 1998. Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease. The Journal of Pathology 186 (4):416–21. doi: 10.1002/(sici)1096-9896(199812)186:4 < 416::aid-path201 > 3.0.co;2-u.
   PubMed Web of Science ®Google Scholar
• Ding, S., S. Xu, J. Fang, and H. Jiang. 2020. The protective effect of polyphenols for colorectal cancer. Frontiers in Immunology 11:1407. doi: 10.3389/fimmu.2020.01407.
   PubMed Web of Science ®Google Scholar
• Ding, Y., Y. M. Yan, D. Chen, L. W. Ran, J. Mi, L. Lu, B. Jing, X. Y. Li, X. X. Zeng, and Y. L. Cao. 2019. Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice. Food & Function 10 (6):3671–83. doi: 10.1039/c9fo00638a.
   PubMed Web of Science ®Google Scholar
• Docherty, M. J., R. Carter, W. Jones, III, and M. S. Wallace. 2011. Managing pain in inflammatory bowel disease. Gastroenterology & Hepatology 7 (9):592.
   PubMedGoogle Scholar
• Doi, M. 1999. Central retinal vein occlusion during remission of ulcerative colitis. Japanese Journal of Ophthalmology 43 (3):213–6. doi: 10.1016/S0021-5155(99)00010-6.
   PubMed Web of Science ®Google Scholar
• Donno, D., G. L. Beccaro, M. G. Mellano, A. K. Cerutti, and G. Bounous. 2015. Goji berry fruit (Lycium spp.): Antioxidant compound fingerprint and bioactivity evaluation. Journal of Functional Foods 18:1070–85. doi: 10.1016/j.jff.2014.05.020.
   Web of Science ®Google Scholar
• Duboc, H., S. Rajca, D. Rainteau, D. Benarous, M. A. Maubert, E. Quervain, G. Thomas, V. Barbu, L. Humbert, G. Despras, et al. 2013. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 62 (4):531–9. doi: 10.1136/gutjnl-2012-302578.
   PubMed Web of Science ®Google Scholar
• Dursun, R., Y. Zengin, E. Gunduz, M. Icer, H. M. Durgun, M. Daggulli, I. Kaplan, U. Alabalik, and C. Guloglu. 2015. The protective effect of goji berry extract in ischemic reperfusion in testis torsion. International Journal of Clinical and Experimental Medicine 8 (2):2727–33.
   PubMed Web of Science ®Google Scholar
• Eaden, J. A., K. R. Abrams, and J. F. Mayberry. 2001. The risk of colorectal cancer in ulcerative colitis: A meta-analysis. Gut 48 (4):526–35. doi: 10.1136/gut.48.4.526.
   PubMed Web of Science ®Google Scholar
• Ebert, M. N., A. Klinder, W. H. M. Peters, A. Schaferhenrich, W. Sendt, J. Scheele, and B. L. Pool-Zobel. 2003. Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. Carcinogenesis 24 (10):1637–44. doi: 10.1093/carcin/bgg122.
   PubMed Web of Science ®Google Scholar
• Eeckhaut, V., K. Machiels, C. Perrier, C. Romero, S. Maes, B. Flahou, M. Steppe, F. Haesebrouck, B. Sas, R. Ducatelle, et al. 2013. Butyricicoccus pullicaecorum in inflammatory bowel disease. Gut 62 (12):1745–52. doi: 10.1136/gutjnl-2012-303611.
   PubMed Web of Science ®Google Scholar
• Elinav, E., T. Strowig, A. L. Kau, J. Henao-Mejia, C. A. Thaiss, C. J. Booth, D. R. Peaper, J. Bertin, S. C. Eisenbarth, J. I. Gordon, et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145 (5):745–57. doi: 10.1016/j.cell.2011.04.022.
   PubMed Web of Science ®Google Scholar
• Facchin, S., N. Vitulo, M. Calgaro, A. Buda, C. Romualdi, D. Pohl, B. Perini, G. Lorenzon, C. Marinelli, R. D’Inca, et al. 2020. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterology and Motility 32 (10):e13914. doi: 10.1111/nmo.13914.
   PubMed Web of Science ®Google Scholar
• Fakhfakh, J., K. Athmouni, H. Mallek-Fakhfakh, H. Ayedi, and N. Allouche. 2020. Polysaccharide from Lycium arabicum: Structural features, in vitro antioxidant activities and protective effect against oxidative damage in human erythrocytes. Chemistry & Biodiversity 17 (12):e00614. doi: 10.1002/cbdv.202000614.
   Web of Science ®Google Scholar
• Feng, Z. H., H. Q. Jia, X. S. Li, Z. L. Bai, Z. B. Liu, L. J. Sun, Z. L. Zhu, P. Bucheli, O. Ballevre, J. K. Wang, et al. 2010. A milk-based wolfberry preparation prevents prenatal stress-induced cognitive impairment of offspring rats, and inhibits oxidative damage and mitochondrial dysfunction in vitro. Neurochemical Research 35 (5):702–11. doi: 10.1007/s11064-010-0123-5.
   PubMed Web of Science ®Google Scholar
• Firdous, A. P., G. Kuttan, and R. Kuttan. 2015. Anti-inflammatory potential of carotenoid meso-zeaxanthin and its mode of action. Pharmaceutical Biology 53 (7):961–7. doi: 10.3109/13880209.2014.950673.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick, L. R., and P. Jenabzadeh. 2020. IBD and bile acid absorption: Focus on pre-clinical and clinical observations. Frontiers in Physiology 11:7. doi: 10.3389/fphys.2020.00564.
   PubMed Web of Science ®Google Scholar
• Frank, D. N., A. L. S. Amand, R. A. Feldman, E. C. Boedeker, N. Harpaz, and N. R. Pace. 2007. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences of the United States of America 104 (34):13780–5. doi: 10.1073/pnas.0706625104.
   PubMed Web of Science ®Google Scholar
• Fu, P. F., M. Gao, and K. K. L. Yung. 2020. Association of intestinal disorders with Parkinson’s disease and Alzheimer’s disease: A systematic review and meta-analysis. ACS Chemical Neuroscience 11 (3):395–405. doi: 10.1021/acschemneuro.9b00607.
   PubMed Web of Science ®Google Scholar
• Gan, L., S. Hua Zhang, X. L. Yang, and H. B. Xu. 2004. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. International Immunopharmacology 4 (4):563–9. doi: 10.1016/j.intimp.2004.01.023.
   PubMed Web of Science ®Google Scholar
• Gao, K., M. Y. Liu, J. Y. Cao, M. N. Yao, Y. Y. Lu, J. K. Li, X. H. Zhu, Z. F. Yang, and A. D. Wen. 2014. Protective effects of Lycium barbarum polysaccharide on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. Molecules 20 (1):293–308. doi: 10.3390/molecules20010293.
   PubMed Web of Science ®Google Scholar
• Gehart, H., and H. Clevers. 2019. Tales from the crypt: New insights into intestinal stem cells. Nature Reviews. Gastroenterology & Hepatology 16 (1):19–34. doi: 10.1038/s41575-018-0081-y.
   PubMed Web of Science ®Google Scholar
• Gjymishka, A., R. M. Coman, T. M. Brusko, and S. C. Glover. 2013. Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and type 1 diabetes. Immunotherapy 5 (12):1357–66. doi: 10.2217/imt.13.130.
   PubMed Web of Science ®Google Scholar
• Gondim, F. D. A., G. R. de Oliveira, B. C. V. Teles, M. Souza, L. Braga, and E. L. Messias. 2015. A case-control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD). Arquivos de Neuro-Psiquiatria 73 (2):119–24. doi: 10.1590/0004-282x20140223.
   PubMed Web of Science ®Google Scholar
• Gong, H., P. Shen, L. Jin, C. Xing, and F. Tang. 2005. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biotherapy & Radiopharmaceuticals 20 (2):155–62. doi: 10.1089/cbr.2005.20.155.
   PubMed Web of Science ®Google Scholar
• Grondin, J. A., Y. H. Kwon, P. M. Far, S. Haq, and W. I. Khan. 2020. Mucins in intestinal mucosal defense and inflammation: Learning from clinical and experimental studies. Frontiers in Immunology 11:2054. doi: 10.3389/fimmu.2020.02054.
   PubMed Web of Science ®Google Scholar
• Gündüz, E., R. Dursun, Y. Zengin, M. İçer, H. M. Durgun, A. Kanıcı, İ. Kaplan, U. Alabalık, H. Gürbüz, and C. Güloğlu. 2015. Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats. International Journal of Clinical and Experimental Medicine 8 (5):7898–905.
   PubMed Web of Science ®Google Scholar
• Hakonarson, H., and S. F. A. Grant. 2009. Genome-wide association studies in type 1 diabetes, inflammatory bowel disease and other immune-mediated disorders. Seminars in Immunology 21 (6):355–62. doi: 10.1016/j.smim.2009.06.001.
   PubMed Web of Science ®Google Scholar
• Heidarian, F., M. Alebouyeh, S. Shahrokh, H. Balaii, and M. R. Zali. 2019. Altered fecal bacterial composition correlates with disease activity in inflammatory bowel disease and the extent of IL8 induction. Current Research in Translational Medicine 67 (2):41–50. doi: 10.1016/j.retram.2019.01.002.
   PubMed Web of Science ®Google Scholar
• Helander, H. F., and L. Fandriks. 2014. Surface area of the digestive tract—Revisited. Scandinavian Journal of Gastroenterology 49 (6):681–9. doi: 10.3109/00365521.2014.898326.
   PubMed Web of Science ®Google Scholar
• Hellmann, J., H. Andersen, L. Fei, A. Linn, R. Bezold, K. Lake, K. Jackson, D. Meyer, K. Dirksing, E. Bonkowski, et al. 2020. Microbial shifts and shorter time to bowel resection surgery associated with C. Difficile in pediatric Crohn’s disease. Inflammatory Bowel Diseases 26 (8):1212–21. doi: 10.1093/ibd/izz263.
   PubMed Web of Science ®Google Scholar
• Hirano, A., J. Umeno, Y. Okamoto, H. Shibata, Y. Ogura, T. Moriyama, T. Torisu, S. Fujioka, Y. Fuyuno, Y. Kawarabayasi, et al. 2018. Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis. Journal of Gastroenterology and Hepatology 33 (9):1590–7. doi: 10.1111/jgh.14129.
   Web of Science ®Google Scholar
• Ho, Y. S., M. S. Yu, X. F. Yang, K. F. So, W. H. Yuen, and R. C. Chang. 2010. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. Journal of Alzheimer’s Disease: JAD 19 (3):813–27. doi: 10.3233/JAD-2010-1280.
   PubMed Web of Science ®Google Scholar
• Ho, Y. S., M. S. Yu, S. Y. Yik, K. F. So, W. H. Yuen, and R. C. Chang. 2009. Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cellular and Molecular Neurobiology 29 (8):1233–44. doi: 10.1007/s10571-009-9419-x.
   PubMed Web of Science ®Google Scholar
• Honneffer, J. B., Y. Minamoto, and J. S. Suchodolski. 2014. Microbiota alterations in acute and chronic gastrointestinal inflammation of cats and dogs. World Journal of Gastroenterology 20 (44):16489–97. doi: 10.3748/wjg.v20.i44.16489.
   PubMed Web of Science ®Google Scholar
• Hooper, L. V. 2015. Epithelial cell contributions to intestinal immunity. Advances in Immunology 126:129–72. doi: 10.1016/bs.ai.2014.11.003.
   PubMed Web of Science ®Google Scholar
• Huang, K. Y., W. Dong, W. Y. Liu, Y. M. Yan, P. Wan, Y. J. Peng, Y. J. Xu, X. X. Zeng, and Y. L. Cao. 2019. 2-O-beta-D-glucopyranosyl-l-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., modulates gut microbiota and palliates colitis in dextran sodium sulfate-induced colitis in mice. Journal of Agricultural and Food Chemistry 67 (41):11408–19. doi: 10.1021/acs.jafc.9b04411.
   PubMed Web of Science ®Google Scholar
• Huang, K. Y., Y. M. Yan, D. Chen, Y. Zhao, W. Dong, X. X. Zeng, and Y. L. Cao. 2020. Ascorbic acid derivative 2-O-beta-D-glucopyranosyl-L-ascorbic acid from the fruit of Lycium barbarum modulates microbiota in the small intestine and colon and exerts an immunomodulatory effect on cyclophosphamide-treated BALB/c mice. Journal of Agricultural and Food Chemistry 68 (40):11128–43. doi: 10.1021/acs.jafc.0c04253.
   PubMed Web of Science ®Google Scholar
• Huang, W. S., C. H. Tseng, P. C. Chen, C. H. Tsai, C. L. Lin, F. C. Sung, and C. H. Kao. 2014. Inflammatory bowel diseases increase future ischemic stroke risk: A Taiwanese population-based retrospective cohort study. European Journal of Internal Medicine 25 (6):561–5. doi: 10.1016/j.ejim.2014.05.009.
   PubMed Web of Science ®Google Scholar
• Huda-Faujan, N., A. S. Abdulamir, A. B. Fatimah, O. M. Anas, M. Shuhaimi, A. M. Yazid, and Y. Y. Loong. 2010. The impact of the level of the intestinal short chain fatty acids in inflammatory bowel disease patients versus healthy subjects. The Open Biochemistry Journal 4:53–8. doi: 10.2174/1874091X01004010053.
   PubMedGoogle Scholar
• Human Microbiome Project Consortium. 2012. Structure, function and diversity of the healthy human microbiome. Nature 486 (7402):207–14. doi: 10.1038/nature11234.
   PubMed Web of Science ®Google Scholar
• Ilic, T., M. Dodevska, M. Marcetic, D. Bozic, I. Kodranov, and B. Vidovic. 2020. Chemical characterization, antioxidant and antimicrobial properties of goji berries cultivated in Serbia. Foods 9 (11):1614. doi: 10.3390/foods9111614.
   PubMed Web of Science ®Google Scholar
• Im, A. R., Y. H. Kim, M. R. Uddin, S. Chae, H. W. Lee, Y. S. Kim, and M. Y. Lee. 2013. Neuroprotective effects of Lycium chinense Miller against rotenone-induced neurotoxicity in PC12 cells. The American Journal of Chinese Medicine 41 (6):1343–59. doi: 10.1142/S0192415X13500900.
   PubMed Web of Science ®Google Scholar
• Inbaraj, B. S., H. Lu, C. F. Hung, W. B. Wu, C. L. Lin, and B. H. Chen. 2008. Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS. Journal of Pharmaceutical and Biomedical Analysis 47 (4–5):812–8. doi: 10.1016/J.Jpba.2008.04.001.
   PubMed Web of Science ®Google Scholar
• Itzkowitz, S. H., and X. Y. Yio. 2004. Inflammation and cancer—IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation. American Journal of Physiology. Gastrointestinal and Liver Physiology 287 (1):G7–17. doi: 10.1152/ajpgi.00079.2004.
   PubMed Web of Science ®Google Scholar
• Jain, U., A. M. Ver Heul, S. Xiong, M. H. Gregory, E. G. Demers, J. T. Kern, C.-W. Lai, B. D. Muegge, D. A. G. Barisas, J. S. Leal-Ekman, et al. 2021. Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice. Science (New York, N.Y.) 371 (6534):1154–9. doi: 10.1126/science.abd0919.
   PubMed Web of Science ®Google Scholar
• Jalanka, J., J. Cheng, K. Hiippala, J. Ritari, J. Salojarvi, T. Ruuska, M. Kalliomaki, and R. Satokari. 2020. Colonic mucosal microbiota and association of bacterial taxa with the expression of host antimicrobial peptides in pediatric ulcerative colitis. International Journal of Molecular Sciences 21 (17):6044. doi: 10.3390/ijms21176044.
   PubMed Web of Science ®Google Scholar
• Jess, T., M. Gamborg, P. Matzen, P. Munkholm, and T. I. A. Sorensen. 2005. Increased risk of intestinal cancer in Crohn’s disease: A meta-analysis of population-based cohort studies. The American Journal of Gastroenterology 100 (12):2724–9. doi: 10.1111/j.1572-0241.2005.00287.x.
   PubMed Web of Science ®Google Scholar
• Jess, T., B. W. Jensen, M. Andersson, M. Villumsen, and K. H. Allin. 2020. Inflammatory bowel diseases increase risk of type 2 diabetes in a nationwide cohort study. Clinical Gastroenterology and Hepatology 18 (4):881–8.e1. doi: 10.1016/j.cgh.2019.07.052.
   PubMed Web of Science ®Google Scholar
• Jia, H., Y. C. Zhang, X. M. Si, Y. H. Jin, D. Jiang, Z. L. Dai, and Z. L. Wu. 2021. Quercetin alleviates oxidative damage by activating nuclear factor erythroid 2-related factor 2 signaling in porcine enterocytes. Nutrients 13 (2):375. doi: 10.3390/nu13020375.
   PubMed Web of Science ®Google Scholar
• Jia, W., G. X. Xie, and W. P. Jia. 2018. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nature Reviews. Gastroenterology & Hepatology 15 (2):111–28. doi: 10.1038/nrgastro.2017.119.
   PubMed Web of Science ®Google Scholar
• Jiang, Y., Y. Zhang, L. Wark, E. Ortiz, S. Lim, H. He, W. Wang, D. Medeiros, and D. Lin. 2012. Wolfberry water soluble phytochemicals down-regulate ER stress biomarkers and modulate multiple signaling pathways leading to inhibition of proliferation and induction of apoptosis in Jurkat cells. Journal of Nutrition & Food Sciences 1 (S2):1. doi: 10.4172/2155-9600.S2-001.
   Google Scholar
• Johansson, M. E. V., and G. C. Hansson. 2016. Immunological aspects of intestinal mucus and mucins. Nature Reviews. Immunology 16 (10):639–49. doi: 10.1038/nri.2016.88.
   PubMed Web of Science ®Google Scholar
• Kaakoush, N. O., J. Holmes, S. Octavia, S. M. Man, L. Zhang, N. Castano-Rodriguez, A. S. Day, S. T. Leach, D. A. Lemberg, S. Dutt, et al. 2010. Detection of Helicobacteraceae in intestinal biopsies of children with Crohn’s disease. Helicobacter 15 (6):549–57. doi: 10.1111/j.1523-5378.2010.00792.x.
   PubMed Web of Science ®Google Scholar
• Kabeerdoss, J., V. Sankaran, S. Pugazhendhi, and B. S. Ramakrishna. 2013. Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India. BMC Gastroenterology 13 (1):8. doi: 10.1186/1471-230X-13-20.
   PubMedGoogle Scholar
• Kang, Y. F., Y. S. Xue, M. Du, and M. J. Zhu. 2017. Preventive effects of goji berry on dextran-sulfate-sodium-induced colitis in mice. The Journal of Nutritional Biochemistry 40:70–6. doi: 10.1016/j.jnutbio.2016.10.009.
   PubMed Web of Science ®Google Scholar
• Kang, Y. F., G. Yang, S. M. Zhang, C. F. Ross, and M. J. Zhu. 2018. Goji berry modulates gut microbiota and alleviates colitis in IL‐10‐deficient mice. Molecular Nutrition & Food Research 62 (22):1800535. doi: 10.1002/mnfr.201800535.
   Web of Science ®Google Scholar
• Kaplan, G. G., and S. C. Ng. 2016. Globalisation of inflammatory bowel disease: Perspectives from the evolution of inflammatory bowel disease in the UK and China. The Lancet. Gastroenterology & Hepatology 1 (4):307–16. doi: 10.1016/S2468-1253(16)30077-2.
   PubMed Web of Science ®Google Scholar
• Karioti, A., M. C. Bergonzi, F. F. Vincieri, and A. R. Bilia. 2014. Validated method for the analysis of goji berry, a rich source of zeaxanthin dipalmitate. Journal of Agricultural and Food Chemistry 62 (52):12529–35. doi: 10.1021/jf503769s.
   PubMed Web of Science ®Google Scholar
• Kaur, C. P., J. Vadivelu, and S. Chandramathi. 2018. Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases. Journal of Digestive Diseases 19 (5):262–71. doi: 10.1111/1751-2980.12595.
   PubMed Web of Science ®Google Scholar
• Ke, M., X. J. Zhang, Z. H. Han, H. Y. Yu, Y. Lin, W. G. Zhang, F. H. Sun, and T. J. Wang. 2011. Extraction, purification of Lycium barbarum polysaccharides and bioactivity of purified fraction. Carbohydrate Polymers 86 (1):136–41. doi: 10.1016/j.carbpol.2011.04.023.
   Web of Science ®Google Scholar
• Keshavarzian, A., A. Banan, A. Farhadi, S. Komanduri, E. Mutlu, Y. Zhang, and J. Z. Fields. 2003. Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease. Gut 52 (5):720–8. doi: 10.1136/gut.52.5.720.
   PubMed Web of Science ®Google Scholar
• Kiernan, M. G., J. C. Coffey, K. McDermott, P. D. Cotter, R. Cabrera-Rubio, P. A. Kiely, and C. P. Dunne. 2019. The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis. Journal of Crohn’s & Colitis 13 (1):58–66. doi: 10.1093/ecco-jcc/jjy136.
   PubMed Web of Science ®Google Scholar
• Kim, J. S., and H. Y. Chung. 2009. GC-MS analysis of the volatile components in dried boxthorn (Lycium chinensis) fruit. Journal of the Korean Society for Applied Biological Chemistry 52 (5):516–24. doi: 10.3839/jksabc.2009.088.
   Google Scholar
• Koh, A., F. De Vadder, P. Kovatcheva-Datchary, and F. Backhed. 2016. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell 165 (6):1332–45. doi: 10.1016/j.cell.2016.05.041.
   PubMed Web of Science ®Google Scholar
• Konarska, A. 2018. Microstructural and histochemical characteristics of Lycium barbarum L. fruits used in folk herbal medicine and as functional food. Protoplasma 255 (6):1839–54. doi: 10.1007/s00709-018-1277-2.
   PubMed Web of Science ®Google Scholar
• Kosińska-Cagnazzo, A., B. Weber, R. Chablais, J. F. Vouillamoz, B. Molnár, J. Crovadore, F. Lefort, and W. Andlauer. 2017. Bioactive compound profile and antioxidant activity of fruits from six goji cultivars cultivated in Switzerland. Journal of Berry Research 7 (1):43–59. doi: 10.3233/JBR-160144.
   Web of Science ®Google Scholar
• Kowalska-Duplaga, K., T. Gosiewski, P. Kapusta, A. Sroka-Oleksiak, A. Wędrychowicz, S. Pieczarkowski, A. H. Ludwig-Słomczyńska, P. P. Wołkow, and K. Fyderek. 2019. Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn’s disease. Scientific Reports 9 (1):11. doi: 10.1038/s41598-019-55290-9.
   PubMedGoogle Scholar
• Kuhn, P., H. M. Kalariya, A. Poulev, D. M. Ribnicky, A. Jaja-Chimedza, D. E. Roopchand, and I. Raskin. 2018. Grape polyphenols reduce gut-localized reactive oxygen species associated with the development of metabolic syndrome in mice. PLoS One 13 (10):e0198716. doi: 10.1371/journal.pone.0198716.
   PubMed Web of Science ®Google Scholar
• Larsson, J., and C. Hansson-Lundblad. 2000. Central retinal vein occlusion in two patients with inflammatory bowel disease. Retina (Philadelphia, Pa.) 20 (6):681–2. doi: 10.1097/00006982-200006000-00022.
   PubMed Web of Science ®Google Scholar
• Laukoetter, M. G., P. Nava, and A. Nusrat. 2008. Role of the intestinal barrier in inflammatory bowel disease. World Journal of Gastroenterology 14 (3):401–7. doi: 10.3748/wjg.14.401.
   PubMed Web of Science ®Google Scholar
• Lavelle, A., and H. Sokol. 2020. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease. Nature Reviews. Gastroenterology & Hepatology 17 (4):223–37. doi: 10.1038/s41575-019-0258-z.
   PubMed Web of Science ®Google Scholar
• Lawrence, T. 2009. The nuclear factor NF-kB pathway in inflammation. Cold Spring Harbor Perspectives in Biology 1 (6):a001651. doi: 10.1101/cshperspect.a001651.
   PubMed Web of Science ®Google Scholar
• Le, K., F. Chiu, and K. Ng. 2007. Identification and quantification of antioxidants in Fructus lycii. Food Chemistry 105 (1):353–63. doi: 10.1016/j.foodchem.2006.11.063.
   Web of Science ®Google Scholar
• Lee, C., B. G. Kim, J. H. Kim, J. Chun, J. P. Im, and J. S. Kim. 2017. Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner. International Immunopharmacology 51:47–56. doi: 10.1016/j.intimp.2017.07.023.
   PubMed Web of Science ®Google Scholar
• Li, H., Y. Liang, K. Chiu, Q. Yuan, B. Lin, R. C. Chang, and K. F. So. 2013. Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection. PLoS One 8 (7):e68881. doi: 10.1371/journal.pone.0068881.
   PubMed Web of Science ®Google Scholar
• Li, W., M. B. Gao, and T. Han. 2020. Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells. Food & Function 11 (4):3741–8. doi: 10.1039/d0fo00030b.
   PubMed Web of Science ®Google Scholar
• Li, X., and X. Li. 2020. Obesity promotes experimental colitis by increasing oxidative stress and mitochondrial dysfunction in the colon. Inflammation 43 (5):1884–92. doi: 10.1007/s10753-020-01261-6.
   PubMed Web of Science ®Google Scholar
• Li, X. M. 2007. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. International Journal of Biological Macromolecules 40 (5):461–5. doi: 10.1016/J.Ijbiomac.2006.11.002.
   PubMed Web of Science ®Google Scholar
• Li, X. M., Y. L. Ma, and X. J. Liu. 2007. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. Journal of Ethnopharmacology 111 (3):504–11. doi: 10.1016/J.Jep.2006.12.024.
   PubMed Web of Science ®Google Scholar
• Liang, G. X., M. A. Conrad, J. R. Kelsen, L. R. Kessler, J. Breton, L. G. Albenberg, S. Marakos, A. Galgano, N. Devas, J. Erlichman, et al. 2020. Dynamics of the stool virome in very early-onset inflammatory bowel disease. Journal of Crohn’s & Colitis 14 (11):1600–10. doi: 10.1093/ecco-jcc/jjaa094.
   PubMed Web of Science ®Google Scholar
• Liang, N. J., and D. D. Kitts. 2018. Amelioration of oxidative stress in Caco-2 cells treated with pro-inflammatory proteins by chlorogenic acid isomers via activation of the Nrf2-Keapl -ARE-signaling pathway. Journal of Agricultural and Food Chemistry 66 (42):11008–17. doi: 10.1021/acs.jafc.8b03983.
   PubMed Web of Science ®Google Scholar
• Liguori, G., B. Lamas, M. L. Richard, G. Brandi, G. da Costa, T. W. Hoffmann, M. P. Di Simone, C. Calabrese, G. Poggioli, P. Langella, et al. 2016. Fungal dysbiosis in mucosa-associated microbiota of Crohn’s disease patients. Journal of Crohn’s and Colitis 10 (3):296–305. doi: 10.1093/ecco-jcc/jjv209.
   PubMed Web of Science ®Google Scholar
• Litvak, Y., M. X. Byndloss, and A. J. Baumler. 2018. Colonocyte metabolism shapes the gut microbiota. Science 362 (6418):eaat9076. doi: 10.1126/science.aat9076.
   PubMed Web of Science ®Google Scholar
• Liu, P. Y., Y. B. Wang, G. Yang, Q. H. Zhang, L. B. Meng, Y. Xin, and X. Jiang. 2021. The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis. Pharmacological Research 165105420. doi: 10.1016/j.phrs.2021.:.
   PubMed Web of Science ®Google Scholar
• Liu, Y., S. Zeng, W. Sun, M. Wu, W. Hu, X. Shen, and Y. Wang. 2014. Comparative analysis of carotenoid accumulation in two goji (Lycium barbarum L. and L. ruthenicum Murr.) fruits. BMC Plant Biology 14:269. doi: 10.1186/s12870-014-0269-4.
   PubMed Web of Science ®Google Scholar
• Liu, Z. G., J. Dang, Q. L. Wang, M. F. Yu, L. Jiang, L. J. Mei, Y. Shao, and Y. D. Tao. 2013. Optimization of polysaccharides from Lycium ruthenicum fruit using RSM and its anti-oxidant activity. International Journal of Biological Macromolecules 61:127–34. doi: 10.1016/j.ijbiomac.2013.06.042.
   PubMed Web of Science ®Google Scholar
• Lloyd-Price, J., C. Arze, A. N. Ananthakrishnan, M. Schirmer, J. Avila-Pacheco, T. W. Poon, E. Andrews, N. J. Ajami, K. S. Bonham, C. J. Brislawn, et al. 2019. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 569 (7758):655–662. doi: 10.1038/s41586-019-1237-9.
   PubMed Web of Science ®Google Scholar
• Loftus, E. V. 2004. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126 (6):1504–17. doi: 10.1053/j.gastro.2004.01.063.
   PubMed Web of Science ®Google Scholar
• Louis, P., G. L. Hold, and H. J. Flint. 2014. The gut microbiota, bacterial metabolites and colorectal cancer. Nature Reviews. Microbiology 12 (10):661–72. doi: 10.1038/nrmicro3344.
   PubMed Web of Science ®Google Scholar
• Luo, Q., Y. Z. Cai, J. Yan, M. Sun, and H. Corke. 2004. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sciences 76 (2):137–49. doi: 10.1016/J.Lfs.2004.04.056.
   PubMed Web of Science ®Google Scholar
• Luo, Q., Z. N. Li, J. Yan, F. Zhu, R. J. Xu, and Y. Z. Cai. 2009. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. Journal of Medicinal Food 12 (4):695–703. doi: 10.1089/jmf.2008.1232.
   PubMed Web of Science ®Google Scholar
• Lutgens, M., M. G. H. van Oijen, G. van der Heijden, F. P. Vleggaar, P. D. Siersema, and B. Oldenburg. 2013. Declining risk of colorectal cancer in inflammatory bowel disease: An updated meta-analysis of population-based cohort studies. Inflammatory Bowel Diseases 19 (4):789–99. doi: 10.1097/MIB.0b013e31828029c0.
   PubMed Web of Science ®Google Scholar
• Lutter, L., D. P. H. van Konijnenburg, E. C. Brand, B. Oldenburg, and F. van Wijk. 2018. The elusive case of human intraepithelial T cells in gut homeostasis and inflammation. Nature Reviews. Gastroenterology & Hepatology 15 (10):637–49. doi: 10.1038/s41575-018-0039-0.
   PubMed Web of Science ®Google Scholar
• Ma, H. Q., T. T. Yu, X. J. Zhao, Y. Zhang, and H. J. Zhang. 2018. Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease. World Journal of Gastroenterology 24 (13):1464–77. doi: 10.3748/wjg.v24.i13.1464.
   PubMed Web of Science ®Google Scholar
• Macpherson, A. J., and T. Uhr. 2004. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303 (5664):1662–5. doi: 10.1126/science.1091334.
   PubMed Web of Science ®Google Scholar
• Maharshak, N., C. D. Packey, M. Ellermann, S. Manick, J. P. Siddle, E. Y. Huh, S. Plevy, R. B. Sartor, and I. M. Carroll. 2013. Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation. Gut Microbes 4 (4):316–24. doi: 10.4161/gmic.25486.
   PubMed Web of Science ®Google Scholar
• Malham, M., B. Lilje, G. Houen, K. Winther, P. S. Andersen, and C. Jakobsen. 2019. The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease. Scandinavian Journal of Gastroenterology 54 (8):969–75. doi: 10.1080/00365521.2019.1644368.
   PubMed Web of Science ®Google Scholar
• Maloy, K. J., and F. Powrie. 2011. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474 (7351):298–306. doi: 10.1038/nature10208.
   PubMed Web of Science ®Google Scholar
• Mancabelli, L., C. Milani, G. A. Lugli, F. Turroni, D. Cocconi, D. van Sinderen, and M. Ventura. 2017. Identification of universal gut microbial biomarkers of common human intestinal diseases by meta-analysis. FEMS Microbiology Ecology 93 (12):fix153. doi: 10.1093/femsec/fix153.
   Web of Science ®Google Scholar
• Mandar, R., and M. Mikelsaar. 1996. Transmission of mother’s microflora to the newborn at birth. Biology of the Neonate 69 (1):30–5. doi: 10.1159/000244275.
   PubMedGoogle Scholar
• Manichanh, C., N. Borruel, F. Casellas, and F. Guarner. 2012. The gut microbiota in IBD. Nature Reviews. Gastroenterology & Hepatology 9 (10):599–608. doi: 10.1038/nrgastro.2012.152.
   PubMed Web of Science ®Google Scholar
• Mankertz, J., M. Amasheh, S. M. Krug, A. Fromm, S. Amasheh, B. Hillenbrand, S. Tavalali, M. Fromm, and J. D. Schulzke. 2009. TNFa up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell and Tissue Research 336 (1):67–77. doi: 10.1007/s00441-009-0751-8.
   PubMed Web of Science ®Google Scholar
• Mao, F., B. X. Xiao, Z. Jiang, J. W. Zhao, X. Huang, and J. M. Guo. 2011. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Medical Oncology 28 (1):121–6. doi: 10.1007/s12032-009-9415-5.
   PubMed Web of Science ®Google Scholar
• Masci, A., S. Carradori, M. A. Casadei, P. Paolicelli, S. Petralito, R. Ragno, and S. Cesa. 2018. Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. Food Chemistry 254:377–89. doi: 10.1016/j.foodchem.2018.01.176.
   PubMed Web of Science ®Google Scholar
• Maslowski, K. M., A. T. Vieira, A. Ng, J. Kranich, F. Sierro, D. Yu, H. C. Schilter, M. S. Rolph, F. Mackay, D. Artis, et al. 2009. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461 (7268):1282–U119. doi: 10.1038/nature08530.
   PubMed Web of Science ®Google Scholar
• Mayorgas, A., I. Dotti, and A. Salas. 2021. Microbial metabolites, postbiotics, and intestinal epithelial function. Molecular Nutrition & Food Research 65 (5):2000188. doi: 10.1002/mnfr.202000188.
   Web of Science ®Google Scholar
• Melhem, H., B. Kaya, C. K. Ayata, P. Hruz, and J. H. Niess. 2019. Metabolite-sensing G protein-coupled receptors connect the diet-microbiota-metabolites axis to inflammatory bowel disease. Cells 8 (5):450. doi: 10.3390/cells8050450.
   PubMed Web of Science ®Google Scholar
• Metwaly, A., A. Dunkel, N. Waldschmitt, A. C. D. Raj, I. Lagkouvardos, A. M. Corraliza, A. Mayorgas, M. Martinez-Medina, S. Reiter, M. Schloter, et al. 2020. Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism. Nature Communications 11 (1):1–15. doi: 10.1038/s41467-020-17956-1.
   PubMed Web of Science ®Google Scholar
• Mi, X. S., Q. Feng, A. C. Y. Lo, R. C. C. Chang, B. Lin, S. K. Chung, and K. F. So. 2012. Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension. PLoS One 7 (10):e45469. doi: 10.1371/journal.pone.0045469.
   PubMed Web of Science ®Google Scholar
• Miao, Y., B. X. Xiao, Z. Jiang, Y. A. Guo, F. Mao, J. W. Zhao, X. Huang, and J. M. Guo. 2010. Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide. Medical Oncology 27 (3):785–90. doi: 10.1007/s12032-009-9286-9.
   PubMed Web of Science ®Google Scholar
• Mohammadifard, N., K. H. Humphries, C. Gotay, G. Mena-Sanchez, J. Salas-Salvado, A. Esmaillzadeh, A. Ignaszewski, and N. Sarrafzadegan. 2019. Trace minerals intake: Risks and benefits for cardiovascular health. Critical Reviews in Food Science and Nutrition 59 (8):1334–46. doi: 10.1080/10408398.2017.1406332.
   PubMed Web of Science ®Google Scholar
• Morgan, X. C., T. L. Tickle, H. Sokol, D. Gevers, K. L. Devaney, D. V. Ward, J. A. Reyes, S. A. Shah, N. LeLeiko, S. B. Snapper, et al. 2012. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biology 13 (9)r79. doi: 10.1186/gb-2012-13-9-:.
   PubMed Web of Science ®Google Scholar
• Moustafa, A., W. Z. Li, E. L. Anderson, E. H. M. Wong, P. S. Dulai, W. J. Sandborn, W. Biggs, S. Yooseph, M. B. Jones, J. C. Venter, et al. 2018. Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clinical and Translational Gastroenterology 9 (1):e132. doi: 10.1038/ctg.2017.58.
   PubMedGoogle Scholar
• Mukhopadhya, I., R. Hansen, E. M. El-Omar, and G. L. Hold. 2012. IBD-what role do Proteobacteria play? Nature Reviews. Gastroenterology & Hepatology 9 (4):219–30. doi: 10.1038/nrgastro.2012.14.
   PubMed Web of Science ®Google Scholar
• Murakami, M., J. Iwamoto, A. Honda, T. Tsuji, M. Tamamushi, H. Ueda, T. Monma, N. Konishi, S. Yara, T. Hirayama, et al. 2018. Detection of gut dysbiosis due to reduced Clostridium subcluster XIVa using the fecal or serum bile acid profile. Inflammatory Bowel Diseases 24 (5):1035–44. doi: 10.1093/ibd/izy022.
   PubMed Web of Science ®Google Scholar
• Ng, S. C., G. G. Kaplan, W. Tang, R. Banerjee, B. Adigopula, F. E. Underwood, D. Tanyingoh, S. C. Wei, W. C. Lin, H. H. Lin, et al. 2019. Population density and risk of inflammatory bowel disease: A prospective population-based study in 13 countries or regions in Asia-Pacific. The American Journal of Gastroenterology 114 (1):107–15. doi: 10.1038/s41395-018-0233-2.
   PubMed Web of Science ®Google Scholar
• Ng, S. C., H. Y. Shi, N. Hamidi, F. E. Underwood, W. Tang, E. I. Benchimol, J. C. Wu, F. K. Chan, J. J. Sung, and G. Kaplan. 2017. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Gastroenterology 152 (5):S970–S1. doi: 10.1016/S0016-5085(17)33292-4.
   Web of Science ®Google Scholar
• Nielsen, D. S. G., B. B. Jensen, P. K. Theil, T. S. Nielsen, K. E. B. Knudsen, and S. Purup. 2018. Effect of butyrate and fermentation products on epithelial integrity in a mucus-secreting human colon cell line. Journal of Functional Foods 40:9–17. doi: 10.1016/j.jff.2017.10.023.
   Web of Science ®Google Scholar
• Niess, J. H., S. Brand, X. Gu, L. Landsman, S. Jung, B. A. McCormick, J. M. Vyas, M. Boes, H. L. Ploegh, J. G. Fox, et al. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 (5707):254–8. doi: 10.1126/science.1102901.
   PubMed Web of Science ®Google Scholar
• Niro, S., A. Fratianni, G. Panfili, L. Falasca, L. Cinquanta, and M. R. Alam. 2017. Nutritional evaluation of fresh and dried goji berries cultivated in Italy. Italian Journal of Food Science 29 (3):398–408.
   Web of Science ®Google Scholar
• Nishino, K., A. Nishida, R. Inoue, Y. Kawada, M. Ohno, S. Sakai, O. Inatomi, S. Bamba, M. Sugimoto, M. Kawahara, et al. 2018. Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease. Journal of Gastroenterology 53 (1):95–106. doi: 10.1007/s00535-017-1384-4.
   PubMed Web of Science ®Google Scholar
• Norman, J. M., S. A. Handley, M. T. Baldridge, L. Droit, C. Y. Liu, B. C. Keller, A. Kambal, C. L. Monaco, G. Zhao, P. Fleshner, et al. 2015. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 160 (3):447–60. doi: 10.1016/j.cell.2015.01.002.
   PubMed Web of Science ®Google Scholar
• Nuij, V., G. M. Fuhler, A. J. Edel, R. J. T. Ouwendijk, M. C. M. Rijk, R. Beukers, R. Quispel, A. J. P. van Tilburg, T. J. Tang, H. Smalbraak, et al. 2015. Benefit of earlier anti-TNF treatment on IBD disease complications? Journal of Crohn’s and Colitis 9 (11):997–1003. doi: 10.1093/ecco-jcc/jjv130.
   PubMed Web of Science ®Google Scholar
• O’Brien, C. L., P. Pavli, D. M. Gordon, and G. E. Allison. 2014. Detection of bacterial DNA in lymph nodes of Crohn’s disease patients using high throughput sequencing. Gut 63 (10):1596–606. doi: 10.1136/gutjnl-2013-305320.
   PubMed Web of Science ®Google Scholar
• O’Keefe, S. J. D. 2016. Diet, microorganisms and their metabolites, and colon cancer. Nature Reviews. Gastroenterology & Hepatology 13 (12):691–706. doi: 10.1038/nrgastro.2016.165.
   PubMed Web of Science ®Google Scholar
• Odenwald, M. A., and J. R. Turner. 2017. The intestinal epithelial barrier: A therapeutic target? Nature Reviews. Gastroenterology & Hepatology 14 (1):9–21. doi: 10.1038/nrgastro.2016.169.
   PubMed Web of Science ®Google Scholar
• Ohata, A., M. Usami, and M. Miyoshi. 2005. Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation. Nutrition 21 (7–8):838–47. doi: 10.1016/j.nut.2004.12.004.
   PubMed Web of Science ®Google Scholar
• Oliveira, G. R., B. C. V. Teles, E. F. Brasil, M. H. L. P. Souza, L. E. T. A. Furtado, C. M. de Castro-Costa, F. H. Rola, L. L. B. C. Braga, and F. d A. A. Gondim. 2008. Peripheral neuropathy and neurological disorders in an unselected Brazilian population-based cohort of IBD patients. Inflammatory Bowel Diseases 14 (3):389–95. doi: 10.1002/ibd.20304.
   PubMed Web of Science ®Google Scholar
• Ouyang, H. X., Y. Q. Li, and Q. W. Xiao. 2007. Simultaneous determination of monosaccharides and oligosaccharides in Lycium barbarum L. by high performance liquid chromatography. Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition 38 (6):1040–2.
   PubMedGoogle Scholar
• Palmela, C., C. Chevarin, Z. L. Xu, J. Torres, G. Sevrin, R. Hirten, N. Barnich, S. C. Ng, and J. F. Colombel. 2018. Adherent-invasive Escherichia coli in inflammatory bowel disease. Gut 67 (3):574–87. doi: 10.1136/gutjnl-2017-314903.
   PubMed Web of Science ®Google Scholar
• Park, Y. M., E. Ha, K. N. Gu, G. Y. Shin, C. K. Lee, K. Kim, and H. J. Kim. 2020. Host genetic and gut microbial signatures in familial inflammatory bowel disease. Clinical and Translational Gastroenterology 11 (7):e00213. doi: 10.14309/ctg.0000000000000213.
   PubMedGoogle Scholar
• Pedro, A. C., J. B. B. Maurer, S. F. Zawadzki-Baggio, S. Avila, G. M. Maciel, and C. W. I. Haminiuk. 2018. Bioactive compounds of organic goji berry (Lycium barbarum L.) prevents oxidative deterioration of soybean oil. Industrial Crops and Products 112:90–7. doi: 10.1016/j.indcrop.2017.10.052.
   Web of Science ®Google Scholar
• Peng, L., Z. R. Li, R. S. Green, I. R. Holzman, and J. Lin. 2009. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. The Journal of Nutrition 139 (9):1619–25. doi: 10.3945/jn.109.104638.
   PubMed Web of Science ®Google Scholar
• Peng, X., and G. Tian. 2001. Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L. Carbohydrate Research 331 (1):95–9. doi: 10.1016/S0008-6215(00)00321-9.
   PubMed Web of Science ®Google Scholar
• Peng, Y. J., Y. M. Yan, P. Wan, D. Chen, Y. Ding, L. W. Ran, J. Mi, L. Lu, Z. J. Zhang, X. Y. Li, et al. 2019. Gut microbiota modulation and anti-inflammatory properties of anthocyanins from the fruits of Lycium ruthenicum Murray in dextran sodium sulfate-induced colitis in mice. Free Radical Biology & Medicine 136:96–108. doi: 10.1016/j.freeradbiomed.2019.04.005.
   PubMed Web of Science ®Google Scholar
• Peng, Y. J., Y. M. Yan, P. Wan, W. Dong, K. Y. Huang, L. W. Ran, J. Mi, L. Lu, X. X. Zeng, and Y. L. Cao. 2020. Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo. Food Research International 130:108952. doi: 10.1016/j.foodres.2019.108952.
   PubMed Web of Science ®Google Scholar
• Peng, Y., C. Ma, Y. Li, K. S. Leung, Z. H. Jiang, and Z. Zhao. 2005. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii). Plant Foods for Human Nutrition 60 (4):161–4. doi: 10.1007/s11130-005-9550-5.
   PubMed Web of Science ®Google Scholar
• Pereira, C., D. Gracio, J. P. Teixeira, and F. Magro. 2015. Oxidative stress and DNA damage: Implications in inflammatory bowel disease. Inflammatory Bowel Diseases 21 (10):2403–17. doi: 10.1097/mib.0000000000000506.
   PubMed Web of Science ®Google Scholar
• Philippe, D., V. Brahmbhatt, F. Foata, Y. Saudan, P. Serrant, S. Blum, J. Benyacoub, and K. Vidal. 2012. Anti-inflammatory effects of lacto-wolfberry in a mouse model of experimental colitis. World Journal of Gastroenterology 18 (38):5351–9. doi: 10.3748/wjg.v18.i38.5351.
   PubMed Web of Science ®Google Scholar
• Podolsky, D. K. 2002. Inflammatory bowel disease. The New England Journal of Medicine 347 (6):417–29. doi: 10.1056/NEJMra020831.
   PubMed Web of Science ®Google Scholar
• Porras, M., M. T. Martin, P. C. Yang, J. Jury, M. H. Perdue, and P. Vergara. 2006. Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation. Inflammatory Bowel Diseases 12 (9):843–52. doi: 10.1097/01.mib.0000231571.88806.62.
   PubMed Web of Science ®Google Scholar
• Potterat, O. 2010. Goji (Lycium barbarum and L. chinense): Phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Medica 76 (1):7–19. doi: 10.1055/s-0029-1186218.
   PubMed Web of Science ®Google Scholar
• Prorok-Hamon, M., M. K. Friswell, A. Alswied, C. L. Roberts, F. Song, P. K. Flanagan, P. Knight, C. Codling, J. R. Marchesi, C. Winstanley, et al. 2014. Colonic mucosa-associated diffusely adherent afaC + Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. Gut 63 (5):761–70. doi: 10.1136/gutjnl-2013-304739.
   PubMed Web of Science ®Google Scholar
• Qian, J. Y., D. Liu, and A. G. Huang. 2004. The efficiency of flavonoids in polar extracts of Lycium chinense Mill fruits as free radical scavenger. Food Chemistry 87 (2):283–8. doi: 10.1016/j.foodchem.2003.11.008.
   Web of Science ®Google Scholar
• Rahmani, J., H. Kord-Varkaneh, A. Hekmatdoost, J. Thompson, C. Clark, A. Salehisahlabadi, A. S. Day, and K. Jacobson. 2019. Body mass index and risk of inflammatory bowel disease: A systematic review and dose-response meta-analysis of cohort studies of over a million participants. Obesity Reviews 20 (9):1312–20. doi: 10.1111/obr.12875.
   PubMed Web of Science ®Google Scholar
• Reeve, V. E., M. Allanson, S. J. Arun, D. Domanski, and N. Painter. 2010. Mice drinking goji berry juice (Lycium barbarum) are protected from UV radiation-induced skin damage via antioxidant pathways. Photochemical & Photobiological Sciences 9 (4):601–7. doi: 10.1039/b9pp00177h.
   PubMed Web of Science ®Google Scholar
• Ren, Z. H., L. X. Na, Y. M. Xu, M. Rozati, J. P. Wang, J. G. Xu, C. H. Sun, K. Vidal, D. Y. Wu, and S. N. Meydani. 2012. Dietary supplementation with lacto-wolfberry enhances the immune response and reduces pathogenesis to influenza infection in mice. The Journal of Nutrition 142 (8):1596–602. doi: 10.3945/jn.112.159467.
   PubMed Web of Science ®Google Scholar
• Rescigno, M. 2011. The intestinal epithelial barrier in the control of homeostasis and immunity. Trends in Immunology 32 (6):256–64. doi: 10.1016/j.it.2011.04.003.
   PubMed Web of Science ®Google Scholar
• Rescigno, M., M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci, J. P. Kraehenbuhl, and P. Ricciardi-Castagnoli. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunology 2 (4):361–7. doi: 10.1038/86373.
   PubMed Web of Science ®Google Scholar
• Rezende, E. S. V., G. C. Lima, and M. M. V. Naves. 2021. Dietary fibers as beneficial microbiota modulators: A proposed classification by prebiotic categories. Nutrition 89:111217. doi: 10.1016/j.nut.2021.111217.
   PubMed Web of Science ®Google Scholar
• Rojo, O. P., A. L. San Roman, E. A. Arbizu, A. D. Martinez, E. R. Sevillano, and A. A. Martinez. 2007. Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease. Inflammatory Bowel Diseases 13 (3):269–77. doi: 10.1002/ibd.20019.
   PubMed Web of Science ®Google Scholar
• Ruan, Z., S. Q. Liu, Y. Zhou, S. M. Mi, G. Liu, X. Wu, K. Yao, H. Assaad, Z. Y. Deng, Y. Q. Hou, et al. 2014. Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS. PLoS One 9 (6):e97815. doi: 10.1371/journal.pone.0097815.
   PubMed Web of Science ®Google Scholar
• Ruan, Z., S. M. Mi, L. L. Zhou, Y. Zhou, J. Li, W. H. Liu, Z. Y. Deng, and Y. L. Yin. 2016. Chlorogenic acid enhances intestinal barrier by decreasing MLCK expression and promoting dynamic distribution of tight junction proteins in colitic rats. Journal of Functional Foods 26:698–708. doi: 10.1016/j.jff.2016.08.038.
   Web of Science ®Google Scholar
• Rui, C., L. Yuxiang, H. Yinju, Z. Qingluan, W. Yang, Z. Qipeng, W. Hao, M. Lin, L. Juan, Z. Chengjun, et al. 2012. Protective effects of Lycium barbarum polysaccharide on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion. Journal of Molecular Histology 43 (5):535–42. doi: 10.1007/s10735-012-9420-4.
   PubMed Web of Science ®Google Scholar
• Rumi, G., I. Szabo, A. Vincze, Z. Matus, G. Toth, and G. Mozsik. 2000. Decrease of serum carotenoids in Crohn’s disease. Journal of Physiology-Paris 94 (2):159–61. doi: 10.1016/S0928-4257(00)00159-5.
   PubMedGoogle Scholar
• Sakamoto, M., A. Takagaki, K. Matsumoto, Y. Kato, K. Goto, and Y. Benno. 2009. Butyricimonas synergistica gen. nov., sp nov and Butyricimonas virosa sp nov., butyric acid-producing bacteria in the family ‘Porphyromonadaceae’ isolated from rat faeces. International Journal of Systematic and Evolutionary Microbiology 59 (Pt 7):1748–53. doi: 10.1099/ijs.0.007674-0.
   PubMedGoogle Scholar
• Santoru, M. L., C. Piras, A. Murgia, V. Palmas, T. Camboni, S. Liggi, I. Ibba, M. A. Lai, S. Orru, A. L. Loizedda, et al. 2017. Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients. Scientific Reports 7 (1):14. doi: 10.1038/s41598-017-10034-5.
   PubMedGoogle Scholar
• Sartor, R. B. 2006. Mechanisms of disease: Pathogenesis of Crohn’s disease and ulcerative colitis. Nature Clinical Practice. Gastroenterology & Hepatology 3 (7):390–407. doi: 10.1038/ncpgasthep0528.
   PubMedGoogle Scholar
• Scheppach, W. 1994. Effects of short chain fatty acids on gut morphology and function. Gut 35 (1 Suppl):S35–S8. doi: 10.1136/gut.35.1_suppl.s35.
   PubMed Web of Science ®Google Scholar
• Schierová, D., J. Březina, J. Mrázek, K. O. Fliegerová, S. Kvasnová, L. Bajer, and P. Drastich. 2020. Gut microbiome changes in patients with active left-sided ulcerative colitis after fecal microbiome transplantation and topical 5-aminosalicylic acid therapy. Cells 9 (10):2283. doi: 10.3390/cells9102283.
   PubMed Web of Science ®Google Scholar
• Schultsz, C., F. M. van den Berg, F. W. ten Kate, G. N. J. Tytgat, and J. Dankert. 1999. The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. Gastroenterology 117 (5):1089–97. doi: 10.1016/S0016-5085(99)70393-8.
   PubMed Web of Science ®Google Scholar
• Schultz, B. M., C. A. Paduro, G. A. Salazar, F. J. Salazar-Echegarai, V. P. Sebastian, C. A. Riedel, A. M. Kalergis, M. Alvarez-Lobos, and S. M. Bueno. 2017. A potential role of Salmonella infection in the onset of inflammatory bowel diseases. Frontiers in Immunology 8:191. doi: 10.3389/fimmu.2017.00191.
   PubMed Web of Science ®Google Scholar
• Sekirov, I., S. L. Russell, L. C. M. Antunes, and B. B. Finlay. 2010. Gut microbiota in health and disease. Physiological Reviews 90 (3):859–904. doi: 10.1152/physrev.00045.2009.
   PubMed Web of Science ®Google Scholar
• Shi, T. L., X. Y. Bian, Z. X. Yao, Y. W. Wang, W. N. Gao, and C. J. Guo. 2020. Quercetin improves gut dysbiosis in antibiotic-treated mice. Food & Function 11 (9):8003–13. doi: 10.1039/D0FO01439G.
   PubMed Web of Science ®Google Scholar
• Siegel, R. L., K. D. Miller, and A. Jemal. 2020. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians 70 (1):7–30. doi: 10.3322/caac.21590.
   PubMed Web of Science ®Google Scholar
• Sinha, S. R., Y. Haileselassie, L. P. Nguyen, C. Tropini, M. Wang, L. S. Becker, D. Sim, K. Jarr, E. T. Spear, G. Singh, et al. 2020. Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation. Cell Host & Microbe 27 (4):659–70.e5. doi: 10.1016/j.chom.2020.01.021.
   PubMed Web of Science ®Google Scholar
• Skenderidis, P., C. Mitsagga, D. Lampakis, K. Petrotos, and I. Giavasis. 2019. The effect of encapsulated powder of goji berry (Lycium barbarum) on growth and survival of probiotic bacteria. Microorganisms 8 (1):57. doi: 10.3390/microorganisms8010057.
   PubMed Web of Science ®Google Scholar
• Sokol, H., S. Jegou, C. McQuitty, M. Straub, V. Leducq, C. Landman, J. Kirchgesner, G. L. Gall, A. Bourrier, I. Nion-Larmurier, et al. 2018. Specificities of the intestinal microbiota in patients with inflammatory bowel disease and Clostridium difficile infection. Gut Microbes 9 (1):55–60. doi: 10.1080/19490976.2017.1361092.
   PubMed Web of Science ®Google Scholar
• Sokol, H., V. Leducq, H. Aschard, H. P. Pham, S. Jegou, C. Landman, D. Cohen, G. Liguori, A. Bourrier, I. Nion-Larmurier, et al. 2017. Fungal microbiota dysbiosis in IBD. Gut 66 (6):1039–48. doi: 10.1136/gutjnl-2015-310746.
   PubMed Web of Science ®Google Scholar
• Sokol, H., P. Seksik, J. P. Furet, O. Firmesse, I. Nion-Larmurier, L. Beaugerie, J. Cosnes, G. Corthier, P. Marteau, and J. Doré. 2009. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflammatory Bowel Diseases 15 (8):1183–9. doi: 10.1002/ibd.20903.
   PubMed Web of Science ®Google Scholar
• Sommer, F., and F. Backhed. 2013. The gut microbiota—Masters of host development and physiology. Nature Reviews. Microbiology 11 (4):227–38. doi: 10.1038/nrmicro2974.
   PubMed Web of Science ®Google Scholar
• Song, M. K., N. K. Salam, B. D. Roufogalis, and T. H. Huang. 2011. Lycium barbarum (goji berry) extracts and its taurine component inhibit PPAR-γ-dependent gene transcription in human retinal pigment epithelial cells: Possible implications for diabetic retinopathy treatment. Biochemical Pharmacology 82 (9):1209–18. doi: 10.1016/j.bcp.2011.07.089.
   PubMed Web of Science ®Google Scholar
• Spits, H., and J. P. Di Santo. 2011. The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling. Nature Immunology 12 (1):21–7. doi: 10.1038/ni.1962.
   PubMed Web of Science ®Google Scholar
• Stagg, A. J., A. L. Hart, S. C. Knight, and M. A. Kamm. 2003. The dendritic cell: Its role in intestinal inflammation and relationship with gut bacteria. Gut 52 (10):1522–9. doi: 10.1136/gut.52.10.1522.
   PubMed Web of Science ®Google Scholar
• Sun, M. M., W. Wu, Z. J. Liu, and Y. Z. Cong. 2017. Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases. Journal of Gastroenterology 52 (1):1–8. doi: 10.1007/s00535-016-1242-9.
   PubMed Web of Science ®Google Scholar
• Sun, X. F., M. Du, D. A. Navarre, and M. J. Zhu. 2018. Purple potato extract promotes intestinal epithelial differentiation and barrier function by activating AMP-activated protein kinase. Molecular Nutrition & Food Research 62 (4):1700536. doi: 10.1002/mnfr.201700536.
   Web of Science ®Google Scholar
• Suzuki, K., B. Meek, Y. Doi, M. Muramatsu, T. Chiba, T. Honjo, and S. Fagarasan. 2004. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proceedings of the National Academy of Sciences of the United States of America 101 (7):1981–6. doi: 10.1073/Pnas.0307317101.
   PubMed Web of Science ®Google Scholar
• Suzuki, T. 2013. Regulation of intestinal epithelial permeability by tight junctions. Cellular and Molecular Life Sciences: CMLS 70 (4):631–59. doi: 10.1007/s00018-012-1070-x.
   PubMed Web of Science ®Google Scholar
• Swidsinski, A., A. Ladhoff, A. Pernthaler, S. Swidsinski, V. Loening-Baucke, M. Ortner, J. Weber, U. Hoffmann, S. Schreiber, M. Dietel, et al. 2002. Mucosal flora in inflammatory bowel disease. Gastroenterology 122 (1):44–54. doi: 10.1053/gast.2002.30294.
   PubMed Web of Science ®Google Scholar
• Tang, L., Y. Zhang, Y. Jiang, L. Willard, E. Ortiz, L. Wark, D. Medeiros, and D. Lin. 2011. Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Experimental Biology and Medicine 236 (9):1051–63. doi: 10.1258/ebm.2011.010400.
   Web of Science ®Google Scholar
• Tian, B. M., Z. Q. Zhang, J. H. Zhao, Q. Y. Ma, H. C. Liu, C. X. Nie, Z. Y. Ma, W. An, and J. X. Li. 2021. Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice. International Journal of Food Science & Technology 56 (1):103–14. doi: 10.1111/ijfs.14606.
   Web of Science ®Google Scholar
• Tian, B. M., J. H. Zhao, M. Zhang, Z. F. Chen, Q. Y. Ma, H. C. Liu, C. X. Nie, Z. Q. Zhang, W. An, and J. X. Li. 2021. Lycium ruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota. Molecular Nutrition & Food Research 65 (8):2170017. doi: 10.1002/mnfr.202000745.
   Web of Science ®Google Scholar
• Tong, M. M., X. X. Li, L. W. Parfrey, B. Roth, A. Ippoliti, B. Wei, J. Borneman, D. P. B. McGovern, D. N. Frank, E. Li, et al. 2013. A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease. PLoS One 8 (11):e80702. doi: 10.1371/journal.pone.0080702.
   PubMed Web of Science ®Google Scholar
• Toyoda-Ono, Y., M. Maeda, M. Nakao, M. Yoshimura, N. Sugiura-Tomimori, and H. Fukami. 2004. 2-O-(beta-D-glucopyranosyl)ascorbic acid, a novel ascorbic acid analogue isolated from Lycium fruit. Journal of Agricultural and Food Chemistry 52 (7):2092–6. doi: 10.1021/jf035445w.
   PubMed Web of Science ®Google Scholar
• Triantafillidis, J. K., G. Nasioulas, and P. A. Kosmidis. 2009. Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Research 29 (7):2727–37.
   PubMed Web of Science ®Google Scholar
• Turner, J. R. 2009. Intestinal mucosal barrier function in health and disease. Nature Reviews. Immunology 9 (11):799–809. doi: 10.1038/nri2653.
   PubMed Web of Science ®Google Scholar
• Van der Sluis, M., B. A. De Koning, A. C. De Bruijn, A. Velcich, J. P. Meijerink, J. B. Van Goudoever, H. A. Buller, J. Dekker, I. Van Seuningen, I. B. Renes, et al. 2006. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131 (1):117–29. doi: 10.1053/j.gastro.2006.04.020.
   PubMed Web of Science ®Google Scholar
• Venegas, D. P., M. K. De la Fuente, G. Landskron, M. J. Gonzalez, R. Quera, G. Dijkstra, H. J. M. Harmsen, K. N. Faber, and M. A. Hermoso. 2019. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology 10:16. doi: 10.3389/fimmu.2019.00277.
   PubMed Web of Science ®Google Scholar
• Vieira, M. M., J. Paik, W. S. Blaner, A. M. Soares, R. M. S. Mota, R. L. Guerrant, and A. A. M. Lima. 2008. Carotenoids, retinol, and intestinal barrier function in children from Northeastern Brazil. Journal of Pediatric Gastroenterology & Nutrition 47 (5):652–9. doi: 10.1097/MPG.0b013e31816bf4bf.
   PubMed Web of Science ®Google Scholar
• Vulić, J. J., J. M. Čanadanović-Brunet, G. S. Ćetković, S. M. Djilas, V. T. Tumbas Šaponjac, and S. S. Stajčić. 2016. Bioactive compounds and antioxidant properties of goji fruits (Lycium barbarum L.) cultivated in Serbia. Journal of the American College of Nutrition 35 (8):692–8. doi: 10.1080/07315724.2016.1142404.
   PubMed Web of Science ®Google Scholar
• Wang, H. B., S. M. Zhang, Q. W. Shen, and M. J. Zhu. 2019. A metabolomic explanation on beneficial effects of dietary Goji on intestine inflammation. Journal of Functional Foods 53:109–14. doi: 10.1016/j.jff.2018.12.014.
   Web of Science ®Google Scholar
• Wang, H. Q., J. N. Li, W. W. Tao, X. Zhang, X. J. Gao, J. J. Yong, J. J. Zhao, L. M. Zhang, Y. Z. Li, and J. A. Duan. 2018. Lycium ruthenicum studies: Molecular biology, phytochemistry and pharmacology. Food Chemistry 240:759–66. doi: 10.1016/j.foodchem.2017.08.026.
   PubMed Web of Science ®Google Scholar
• Wang, Z. F., Y. Liu, Y. J. Sun, Q. Mou, B. Wang, Y. Zhang, and L. J. Huang. 2014. Structural characterization of LbGpl from the fruits of Lycium barbarum L. Food Chemistry 159:137–42. doi: 10.1016/j.foodchem.2014.02.171.
   PubMed Web of Science ®Google Scholar
• Warner, R. H., F. M. Stevens, and C. F. McCarthy. 1999. Salivary SIgA and SIgA 1 in coeliac disease, inflammatory bowel disease and controls. Irish Journal of Medical Science 168 (1):33–5. doi: 10.1007/BF02939578.
   PubMed Web of Science ®Google Scholar
• Wawruszak, A., A. Czerwonka, K. Okła, and W. Rzeski. 2016. Anticancer effect of ethanol Lycium barbarum (Goji berry) extract on human breast cancer T47D cell line. Natural Product Research 30 (17):1993–6. doi: 10.1080/14786419.2015.1101691.
   PubMed Web of Science ®Google Scholar
• Wetters, S., T. Horn, and P. Nick. 2018. Goji who? Morphological and DNA based authentication of a “superfood”. Frontiers in Plant Science 9:1859. doi: 10.3389/fpls.2018.01859.
   PubMed Web of Science ®Google Scholar
• Willing, B. P., J. Dicksved, J. Halfvarson, A. F. Andersson, M. Lucio, Z. Zheng, G. Jarnerot, C. Tysk, J. K. Jansson, and L. Engstrand. 2010. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139 (6):1844–54.e1. doi: 10.1053/j.gastro.2010.08.049.
   PubMed Web of Science ®Google Scholar
• Wirbel, J., P. T. Pyl, E. Kartal, K. Zych, A. Kashani, A. Milanese, J. S. Fleck, A. Y. Voigt, A. Palleja, R. Ponnudurai, et al. 2019. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nature Medicine 25 (4):679–89. doi: 10.1038/s41591-019-0406-6.
   PubMed Web of Science ®Google Scholar
• Wu, D. T., H. Guo, S. Lin, S. C. Lam, L. Zhao, D. R. Lin, and W. Qin. 2018. Review of the structural characterization, quality evaluation, and industrial application of Lycium barbarum polysaccharides. Trends in Food Science & Technology 79:171–83. doi: 10.1016/j.tifs.2018.07.016.
   Web of Science ®Google Scholar
• Xia, W. R., X. A. Li, I. Khan, L. Yin, L. Su, W. K. Leong, X. Q. Bian, J. Y. Su, W. L. W. Hsiao, and G. X. Huang. 2020. Lycium berry polysaccharides strengthen gut microenvironment and modulate gut microbiota of the mice. Evidence-Based Complementary and Alternative Medicine 2020:1–10. doi: 10.1155/2020/8097021.
   Web of Science ®Google Scholar
• Xiao, J., E. C. Liong, Y. P. Ching, R. C. Chang, K. F. So, M. L. Fung, and G. L. Tipoe. 2012. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. Journal of Ethnopharmacology 139 (2):462–70. doi: 10.1016/j.jep.2011.11.033.
   PubMed Web of Science ®Google Scholar
• Xiao, J., F. Y. Xing, J. Huo, M. L. Fung, E. C. Liong, Y. P. Ching, A. M. Xu, R. C. C. Chang, K. F. So, and G. L. Tipoe. 2014. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Scientific Reports 4:5587. doi: 10.1038/srep05587.
   PubMed Web of Science ®Google Scholar
• Xiao, Z. L., Z. M. Pei, M. Yuan, X. L. Li, S. J. Chen, and L. J. Xu. 2015. Risk of stroke in patients with inflammatory bowel disease: A systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Siseases 24 (12):2774–80. doi: 10.1016/j.jstrokecerebrovasdis.2015.08.008.
   PubMed Web of Science ®Google Scholar
• Xie, M. G., Y. Q. Fei, Y. Wang, W. Y. Wang, and Z. Wang. 2021. Chlorogenic acid alleviates colon mucosal damage induced by a high-fat diet via gut microflora adjustment to increase short-chain fatty acid accumulation in rats. Oxidative Medicine and Cellular Longevity 2021:3456542. doi: 10.1155/2021/3456542.
   PubMed Web of Science ®Google Scholar
• Xing, X., F. Liu, J. Xiao, and K. F. So. 2016. Neuro-protective mechanisms of Lycium barbarum. NeuroMolecular Medicine 2016:1–11. doi: 10.1007/s12017-016-8393-y.
   Google Scholar
• Xu, Y. Q., Y. Zhu, X. T. Li, and B. G. Sun. 2020. Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism. Trends in Food Science & Technology 100:118–30. doi: 10.1016/j.tifs.2020.02.026.
   Web of Science ®Google Scholar
• Xue, Y. S., M. Du, and M. J. Zhu. 2017. Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7. Free Radical Biology & Medicine 108:760–9. doi: 10.1016/j.freeradbiomed.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Xue, Y. W., F. Huang, R. X. Tang, Q. S. Fan, B. Zhang, Z. J. Xu, X. M. Sun, and Z. Ruan. 2019. Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats. Food and Chemical Toxicology 133:110751. doi: 10.1016/j.fct.2019.110751.
   PubMed Web of Science ®Google Scholar
• Yan, Y. M., Y. J. Peng, J. L. Tang, J. Mi, L. Lu, X. Y. Li, L. W. Ran, X. X. Zeng, and Y. L. Cao. 2018. Effects of anthocyanins from the fruit of Lycium ruthenicum Murray on intestinal microbiota. Journal of Functional Foods 48:533–41. doi: 10.1016/j.jff.2018.07.053.
   Web of Science ®Google Scholar
• Yang, D., S. Y. Li, C. M. Yeung, R. C. Chang, K. F. So, D. Wong, and A. C. Lo. 2012. Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS One 7 (3):e33596. doi: 10.1371/journal.pone.0033596.
   PubMed Web of Science ®Google Scholar
• Yang, G., S. Bibi, M. Du, T. Suzuki, and M. J. Zhu. 2017. Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective. Critical Reviews in Food Science and Nutrition 57 (18):3830–9. doi: 10.1080/10408398.2016.1152230.
   PubMed Web of Science ®Google Scholar
• Yang, G., Y. S. Xue, H. Y. Zhang, M. Du, and M. J. Zhu. 2015. Favourable effects of grape seed extract on intestinal epithelial differentiation and barrier function in IL10-deficient mice. The British Journal of Nutrition 114 (1):15–23. doi: 10.1017/s0007114515001415.
   PubMed Web of Science ®Google Scholar
• Yang, X., H. Bai, W. Cai, J. Li, Q. Zhou, Y. Wang, J. Han, X. Zhu, M. Dong, and D. Hu. 2013. Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats. Chemico-Biological Interactions 204 (3):166–72. doi: 10.1016/j.cbi.2013.05.010.
   PubMed Web of Science ®Google Scholar
• Yang, Y., W. Li, Y. Li, Q. Wang, L. Gao, and J. Zhao. 2014. Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K/AKT signaling. Oxidative Medicine and Cellular Longevity 2014:145641. doi: 10.1155/2014/145641.
   PubMed Web of Science ®Google Scholar
• Yin, G. H., and Y. L. Dang. 2008. Optimization of extraction technology of the Lycium barbarum polysaccharides by Box-Behnken statistical design. Carbohydrate Polymers 74 (3):603–10. doi: 10.1016/j.carbpol.2008.04.025.
   Web of Science ®Google Scholar
• Ying, C. J., L. Chen, S. S. Wang, Y. Z. Mao, H. W. Ling, W. Li, and X. Y. Zhou. 2017. Zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating AKT signalling-pathway. Biomedicine & Pharmacotherapy  90:796–805. doi: 10.1016/j.biopha.2017.04.013.
   PubMed Web of Science ®Google Scholar
• You, T. T., and L. H. Y. Young. 1998. Retinal manifestations of gastrointestinal conditions. International Ophthalmology Clinics 38 (1):197–220. doi: 10.1097/00004397-199803810-00016.
   PubMedGoogle Scholar
• Yu, H. F., L. Wark, H. Ji, L. Willard, Y. Jaing, J. Han, H. He, E. Ortiz, Y. N. Zhang, D. M. Medeiros, et al. 2013. Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice. Molecular Nutrition & Food Research 57 (7):1158–69. doi: 10.1002/Mnfr.201200642.
   PubMed Web of Science ®Google Scholar
• Yuan, Y. F., Y. B. Wang, Y. M. Jiang, K. N. Prasad, J. L. Yang, H. X. Qu, Y. Wang, Y. X. Jia, H. Mo, and B. Yang. 2016. Structure identification of a polysaccharide purified from Lycium barbarium fruit. International Journal of Biological Macromolecules 82:696–701. doi: 10.1016/j.ijbiomac.2015.10.069.
   PubMed Web of Science ®Google Scholar
• Zamani, S., S. H. Shariati, M. R. Zali, H. A. Aghdaei, A. S. Asiabar, S. Bokaie, B. Nomanpour, L. A. Sechi, and M. M. Feizabadi. 2017. Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis. Gut Pathogens 9:53. doi: 10.1186/s13099-017-0202-0.
   PubMed Web of Science ®Google Scholar
• Zhang, J., S. W. Zhu, N. Ma, L. J. Johnston, C. D. Wu, and X. Ma. 2021. Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation. Medicinal Research Reviews 41 (2):1061–88. doi: 10.1002/med.21752.
   PubMed Web of Science ®Google Scholar
• Zhang, Q., W. Chen, J. Zhao, and W. Xi. 2016. Functional constituents and antioxidant activities of eight Chinese native goji genotypes. Food Chemistry 200:230–6. doi: 10.1016/j.foodchem.2016.01.046.
   PubMed Web of Science ®Google Scholar
• Zhang, T. Y., M. U. R. Kayani, L. W. Hong, C. Zhang, J. Zhong, Z. T. Wang, and L. Chen. 2020. Dynamics of the salivary microbiome during different phases of Crohn’s disease. Frontiers in Cellular and Infection Microbiology 10:544704. doi: 10.3389/fcimb.2020.544704.
   PubMed Web of Science ®Google Scholar
• Zhang, Y. K., J. Wang, L. Liu, R. C. Chang, K. F. So, and G. Ju. 2013. The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats. BMC Complementary and Alternative Medicine 13:67. doi: 10.1186/1472-6882-13-67.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Y. Wang, D. W. Chen, B. Yu, P. Zheng, X. B. Mao, Y. H. Luo, Y. Li, and J. He. 2018. Dietary chlorogenic acid supplementation affects gut morphology, antioxidant capacity and intestinal selected bacterial populations in weaned piglets. Food & Function 9 (9):4968–78. doi: 10.1039/C8FO01126E.
   PubMed Web of Science ®Google Scholar
• Zhao, J. H., H. X. Li, Y. Yin, W. An, X. Y. Qin, Y. J. Wang, Y. L. Li, Y. F. Fan, and Y. L. Cao. 2020. Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening. Scientific Reports 10 (1):4354. doi: 10.1038/s41598-020-61064-5.
   PubMed Web of Science ®Google Scholar
• Zhao, L., Q. T. Xiong, C. M. Stary, O. K. Mahgoub, Y. Z. Ye, L. J. Gu, X. X. Xiong, and S. M. Zhu. 2018. Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke. Journal of Neuroinflammation 15 (1):339. doi: 10.1186/s12974-018-1382-3.
   PubMed Web of Science ®Google Scholar
• Zhou, L. S., W. F. Liao, X. Chen, H. Yue, S. J. Li, and K. Ding. 2018. An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ42. Carbohydrate Polymers 195:643–51. doi: 10.1016/j.carbpol.2018.05.022.
   PubMed Web of Science ®Google Scholar
• Zhou, L. S., W. F. Liao, H. Zeng, Y. L. Yao, X. Chen, and K. Ding. 2018. A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing. Carbohydrate Polymers 201:65–74. doi: 10.1016/j.carbpol.2018.08.050.
   PubMed Web of Science ®Google Scholar
• Zhou, X. F., B. W. Zhang, X. L. Zhao, Y. X. Lin, J. Wang, X. W. Wang, N. Hu, and S. Wang. 2021. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis. Food & Function 12 (12):5637–49. doi: 10.1039/d0fo03199b.
   PubMed Web of Science ®Google Scholar
• Zhou, Y., Y. H. Duan, S. C. Huang, X. Zhou, L. S. Zhou, T. T. Hu, Y. F. Yang, J. Lu, K. Ding, D. Guo, et al. 2020. Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice. International Journal of Biological Macromolecules 144:1004–12. doi: 10.1016/j.ijbiomac.2019.09.177.
   PubMed Web of Science ®Google Scholar
• Zhu, W., S. X. Zhou, J. H. Liu, R. J. C. McLean, and W. H. Chu. 2020. Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomedicine & Pharmacotherapy 121:109591. doi: 10.1016/j.biopha.2019.109591.
   PubMed Web of Science ®Google Scholar
• Zhuang, X. J., T. Li, M. Y. Li, S. S. Huang, Y. Qiu, R. Feng, S. H. Zhang, M. H. Chen, L. S. Xiong, and Z. R. Zeng. 2019. Systematic review and meta-analysis: Short-chain fatty acid characterization in patients with inflammatory bowel disease. Inflammatory Bowel Diseases 25 (11):1751–63. doi: 10.1093/ibd/izz188.
   PubMed Web of Science ®Google Scholar
• Zhuang, X. J., C. G. Liu, S. K. Zhan, Z. Y. Tian, N. Li, R. Mao, Z. R. Zeng, and M. H. Chen. 2021. Gut microbiota profile in pediatric patients with inflammatory bowel disease: A systematic review. Frontiers in Pediatrics 9:15. doi: 10.3389/fped.2021.626232.
   Web of Science ®Google Scholar