Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes

References

• Acharya, K. D., H. L. Noh, M. E. Graham, S. Suk, R. H. Friedline, C. C. Gomez, A. E. R. Parakoyi, J. Chen, J. K. Kim, and M. J. Tetel. 2021. Distinct changes in gut microbiota are associated with estradiol-mediated protection from diet-induced obesity in female mice. Metabolites 11 (8):499. doi: 10.3390/metabo11080499.
   PubMed Web of Science ®Google Scholar
• Ahmed, S. B. 2017. Menopause and chronic kidney disease. Seminars in Nephrology 37 (4):404–11. doi: 10.1016/j.semnephrol.2017.05.013.
   Google Scholar
• Al-Zoairy, R., M. T. Pedrini, M. I. Khan, J. Engl, A. Tschoner, C. Ebenbichler, G. Gstraunthaler, K. Salzmann, R. Bakry, and A. Niederwanger. 2017. Serotonin improves glucose metabolism by serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells. Diabetology & Metabolic Syndrome 9:1. doi: 10.1186/s13098-016-0201-1.
   PubMed Web of Science ®Google Scholar
• Alemán, J. O., N. A. Bokulich, J. R. Swann, J. M. Walker, J. C. De Rosa, T. Battaglia, A. Costabile, A. Pechlivanis, Y. Liang, J. L. Breslow, et al. 2018. Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. Journal of Translational Medicine 16 (1):244.
   PubMed Web of Science ®Google Scholar
• Alexander, C., K. S. Swanson, G. C. Fahey, Jr., and K. A. Garleb. 2019. Perspective: Physiologic importance of short-chain fatty acids from nondigestible carbohydrate fermentation. Advances in Nutrition 10 (4):576–89.
   PubMed Web of Science ®Google Scholar
• Aliasgharzadeh, A., P. Dehghan, B. P. Gargari, and M. Asghari-Jafarabadi. 2015. Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: A randomised controlled clinical trial. British Journal of Nutrition 113 (2):321–30. doi: 10.1017/S0007114514003675.
   PubMed Web of Science ®Google Scholar
• Andreasen, A. S., N. Larsen, T. Pedersen-Skovsgaard, R. M. G. Berg, K. Møller, K. D. Svendsen, M. Jakobsen, and B. K. Pedersen. 2010. Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. British Journal of Nutrition 104 (12):1831–8. doi: 10.1017/S0007114510002874.
   PubMed Web of Science ®Google Scholar
• Angelino, D., E. B. Dosz, J. Sun, J. L. Hoeflinger, M. L. Van Tassell, P. Chen, J. M. Harnly, M. J. Miller, and E. H. Jeffery. 2015. Myrosinase-dependent and –independent formation and control of isothiocyanate products of glucosinolate hydrolysis. Frontiers in Plant Science 6:831. doi: 10.3389/fpls.2015.00831.
   PubMed Web of Science ®Google Scholar
• Asemi, Z., S.-A. Alizadeh, K. Ahmad, M. Goli, and A. Esmaillzadeh. 2016. Effects of beta-carotene fortified synbiotic food on metabolic control of patients with type 2 diabetes mellitus: A double-blind randomized cross-over controlled clinical trial. Clinical Nutrition 35 (4):819–25. doi: 10.1016/j.clnu.2015.07.009.
   PubMed Web of Science ®Google Scholar
• Asemi, Z., A. Khorrami-Rad, S.-A. Alizadeh, H. Shakeri, and A. Esmaillzadeh. 2014. Effects of synbiotic food consumption on metabolic status of diabetic patients: A double-blind randomized cross-over controlled clinical trial. Clinical Nutrition 33 (2):198–203. doi: 10.1016/j.clnu.2013.05.015.
   PubMed Web of Science ®Google Scholar
• Baker, J. M., L. Al-Nakkash, and M. M. Herbst-Kralovetz. 2017. Estrogen-gut microbiome axis: Physiological and clinical implications. Maturitas 103:45–53.
   PubMed Web of Science ®Google Scholar
• Balaguer, F., M. Enrique, S. Llopis, M. Barrena, V. Navarro, B. Álvarez, E. Chenoll, D. Ramón, M. Tortajada, and P. Martorell. 2022. Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: A novel postbiotic that reduces fat deposition via IGF-1 pathway. Microbial Biotechnology 15 (3):805–16. doi: 10.1111/1751-7915.13769.
   PubMed Web of Science ®Google Scholar
• Banerjee, M., and M. Saxena. 2012. Interleukin-1 (IL-1) family of cytokines: Role in type 2 diabetes. Clinica Chimica Acta 413 (15-16):1163–70. doi: 10.1016/j.cca.2012.03.021.
   PubMed Web of Science ®Google Scholar
• Blachier, F., M. Andriamihaja, P. Larraufie, E. Ahn, A. Lan, and E. Kim. 2021. Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa. American Journal of Physiology. Gastrointestinal and Liver Physiology 320 (2):G125–35.
   PubMed Web of Science ®Google Scholar
• Bourgonje, M. F., A. R. Bourgonje, A. E. Abdulle, L. M. Kieneker, S. la Bastide-van Gemert, R. T. Gansevoort, S. J. L. Bakker, D. J. Mulder, A. Pasch, J. Saleh, et al. 2021. Systemic oxidative stress, aging and the risk of cardiovascular events in the general female population. Frontiers in Cardiovascular Medicine 8:630543. doi: 10.3389/fcvm.2021.630543.
   PubMed Web of Science ®Google Scholar
• Brahe, L. K., E. L. Chatelier, E. Prifti, N. Pons, S. Kennedy, T. Blaedel, J. Håkansson, T. K. Dalsgaard, T. Hansen, O. Pedersen, et al. 2015a. Dietary modulation of the gut microbiota—A randomised controlled trial in obese postmenopausal women. British Journal of Nutrition 114 (3):406–17. doi: 10.1017/S0007114515001786.
   PubMed Web of Science ®Google Scholar
• Brahe, L. K., E. L. Chatelier, E. Prifti, N. Pons, S. Kennedy, T. Hansen, O. Pedersen, A. Astrup, S. D. Ehrlich, and L. H. Larsen. 2015b. Specific gut microbiota features and metabolic markers in postmenopausal women with obesity. Nutrition & Diabetes 5 (6):e159. doi: 10.1038/nutd.2015.9.
   PubMedGoogle Scholar
• Braxas, H., M. Rafraf, S. K. Hasanabad, and M. A. Jafarabadi. 2019. Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type 2 diabetes mellitus. Canadian Journal of Diabetes 43 (7):490–7. doi: 10.1016/j.jcjd.2019.04.007.
   PubMed Web of Science ®Google Scholar
• Bruce-Keller, A. J., A. J. Richard, S.-O. Fernandez-Kim, D. M. Ribnicky, J. M. Salbaum, S. Newman, R. Carmouche, and J. M. Stephens. 2020. Fenugreek counters the effects of high fat diet on gut microbiota in mice. Scientific Reports 10 (1):1245.
   PubMed Web of Science ®Google Scholar
• Cani, P. D., A. M. Neyrinck, F. Fava, C. Knauf, R. G. Burcelin, K. M. Tuohy, G. Gibson, and N. M. Delzenne. 2007. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50 (11):2374–83. doi: 10.1007/s00125-007-0791-0.
   PubMed Web of Science ®Google Scholar
• Cano, P. G., A. Santacruz, F. M. Trejo, and Y. Sanz. 2013. Bifidobacterium CECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet-fed mice. Obesity 21 (11):2310–21.
   PubMed Web of Science ®Google Scholar
• Cardona, F., C. Andrés-Lacueva, S. Tulipani, F. J. Tinahones, and M. I. Queipo-Ortuño. 2013. Benefits of polyphenols on gut microbiota and implications in human health. The Journal of Nutritional Biochemistry 24 (8):1415–22.
   PubMed Web of Science ®Google Scholar
• Carlsson, S. 2019. Etiology and pathogenesis of latent autoimmune diabetes in adults (LADA) compared to type 2 diabetes. Frontiers in Physiology 10:320.
   PubMed Web of Science ®Google Scholar
• Cavallari, J. F., M. D. Fullerton, B. M. Duggan, K. P. Foley, E. Denou, B. K. Smith, E. M. Desjardins, B. D. Henriksbo, K. J. Kim, B. R. Tuinema, et al. 2017. Muramyl dipeptide-based postbiotics mitigate obesity-induced insulin resistance via IRF4. Cell Metabolism 25 (5):1063–74.e3.
   PubMed Web of Science ®Google Scholar
• Ceriello, A., R. Testa, and S. Genovese. 2016. Clinical implications of oxidative stress and potential role of natural antioxidants in diabetic vascular complications. Nutrition, Metabolism, and Cardiovascular Diseases 26 (4):285–92.
   PubMed Web of Science ®Google Scholar
• Chambers, E. S., A. Viardot, A. Psichas, D. J. Morrison, K. G. Murphy, S. E. K. Zac-Varghese, K. MacDougall, T. Preston, C. Tedford, G. S. Finlayson, et al. 2015. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 64 (11):1744–54. doi: 10.1136/gutjnl-2014-307913.
   PubMed Web of Science ®Google Scholar
• Chaturvedi, U., A. Shrivastava, S. Bhadauria, J. K. Saxena, and G. Bhatia. 2013. A Mechanism-based pharmacological evaluation of efficacy of Trigonella foenum graecum (fenugreek) seeds in regulation of dyslipidemia and oxidative stress in hyperlipidemic rats. Journal of Cardiovascular Pharmacology 61:505–12.
   PubMed Web of Science ®Google Scholar
• Chaudhari, A., and M. K. Dwivedi. 2022. Chapter 1—The concept of probiotics, prebiotics, postbiotics, synbiotics, nutribiotics, and pharmabiotics. In Probiotics in the prevention and management of human diseases, ed. M. K. Dwivedi, et al., 1–11. Cambridge, MA: Academic Press.
   Google Scholar
• Chen, H., and S. Sang. 2014. Biotransformation of tea polyphenols by gut microbiota. Journal of Functional Foods 7:26–42. doi: 10.1016/j.jff.2014.01.013.
   Web of Science ®Google Scholar
• Chen, K. L., and Z. Madak-Erdogan. 2016. Estrogen and microbiota crosstalk: Should we pay attention? Trends in Endocrinology and Metabolism 27 (11):752–5. doi: 10.1016/j.tem.2016.08.001.
   PubMed Web of Science ®Google Scholar
• Chen, K. L., and Z. Madak-Erdogan. 2018. Estrogens and female liver health. Steroids 133:38–43.
   PubMed Web of Science ®Google Scholar
• Chen, P., Q. Zhang, H. Dang, X. Liu, F. Tian, J. Zhao, Y. Chen, H. Zhang, and W. Chen. 2014. Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin. Nutrition 30 (9):1061–8. doi: 10.1016/j.nut.2014.03.022.
   PubMed Web of Science ®Google Scholar
• Costantini, L., R. Molinari, B. Farinon, and N. Merendino. 2017. Impact of omega-3 fatty acids on the gut microbiota. International Journal of Molecular Sciences 18 (12):2645. doi: 10.3390/ijms18122645.
   PubMed Web of Science ®Google Scholar
• Cunningham, A. L., J. W. Stephens, and D. A. Harris. 2021. Gut microbiota influence in type 2 diabetes mellitus (T2DM). Gut Pathogens 13 (1):50.
   PubMed Web of Science ®Google Scholar
• Dashti, S. G., J. A. Simpson, A. Karahalios, V. Viallon, M. Moreno-Betancur, L. C. Gurrin, R. J. MacInnis, B. M. Lynch, L. Baglietto, H. A. Morris, et al. 2020. Adiposity and estrogen receptor‐positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol. International Journal of Cancer 146 (6):1541–52.
   PubMed Web of Science ®Google Scholar
• De Paoli, M., A. Zakharia, and G. H. Werstuck. 2021. The role of estrogen in insulin resistance: A review of clinical and pre-clinical data. The American Journal of Pathology 191 (9):1490–8. doi: 10.1016/j.ajpath.2021.05.011.
   PubMed Web of Science ®Google Scholar
• Dehghan, P., B. Pourghassem Gargari, and M. Asghari Jafar-abadi. 2014. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial. Nutrition 30 (4):418–23. doi: 10.1016/j.nut.2013.09.005.
   PubMed Web of Science ®Google Scholar
• Delzenne, N. M., P. D. Cani, A. Everard, A. M. Neyrinck, and L. B. Bindels. 2015. Gut microorganisms as promising targets for the management of type 2 diabetes. Diabetologia 58 (10):2206–17.
   PubMed Web of Science ®Google Scholar
• Depommier, C., M. Van Hul, A. Everard, N. M. Delzenne, W. M. De Vos, and P. D. Cani. 2020. Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice. Gut Microbes 11 (5):1231–45.
   PubMed Web of Science ®Google Scholar
• Di Meo, F., S. Margarucci, U. Galderisi, S. Crispi, and G. Peluso. 2019. Curcumin, gut microbiota, and neuroprotection. Nutrients 11:2426.
   PubMed Web of Science ®Google Scholar
• Eastell, R., T. W. O’Neill, L. C. Hofbauer, B. Langdahl, I. R. Reid, D. T. Gold, and S. R. Cummings. 2016. Postmenopausal osteoporosis. Nature Reviews. Disease Primers 2:16069. doi: 10.1038/nrdp.2016.69.
   PubMed Web of Science ®Google Scholar
• Everard, A., C. Belzer, L. Geurts, J. P. Ouwerkerk, C. Druart, L. B. Bindels, Y. Guiot, M. Derrien, G. G. Muccioli, and N. M. Delzenne. 2013. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 110:9066–71.
   Google Scholar
• Everard, A., S. Matamoros, L. Geurts, N. M. Delzenne, and P. D. Cani. 2014. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. mBio 5 (3):e01011–01014. doi: 10.1128/mBio.01011-14.
   PubMed Web of Science ®Google Scholar
• Fang, J., H. Wang, Y. Zhou, H. Zhang, H. Zhou, and X. Zhang. 2021. Slimy partners: The mucus barrier and gut microbiome in ulcerative colitis. Experimental & Molecular Medicine 53 (5):772–87. doi: 10.1038/s12276-021-00617-8.
   PubMed Web of Science ®Google Scholar
• Fernandez, M. A., and A. Marette. 2018. Novel perspectives on fermented milks and cardiometabolic health with a focus on type 2 diabetes. Nutrition Reviews 76 (Suppl 1):16–28.
   PubMedGoogle Scholar
• Frampton, J., K. G. Murphy, G. Frost, and E. S. Chambers. 2020. Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function. Nature Metabolism 2 (9):840–8.
   PubMedGoogle Scholar
• Franzosa, E. A., A. Sirota-Madi, J. Avila-Pacheco, N. Fornelos, H. J. Haiser, S. Reinker, T. Vatanen, A. B. Hall, H. Mallick, L. J. McIver, et al. 2019. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nature Microbiology 4 (2):293–305. doi: 10.1038/s41564-018-0306-4.
   PubMed Web of Science ®Google Scholar
• Fukuda, M. M. Kobayashi, and Y. Honda. 2017. Chapter 6—Functional components and health benefits of fermented soymilk. In Soft chemistry and food fermentation, ed. A. M. Grumezescu and A. M. Holban, 145–78. Cambridge, MA: Academic Press.
   Google Scholar
• Ge, T., J. Yang, S. Zhou, Y. Wang, Y. Li, and X. Tong. 2020. The role of the pentose phosphate pathway in diabetes and cancer. Frontiers in Endocrinology 11:365. doi: 10.3389/fendo.2020.00365.
   PubMed Web of Science ®Google Scholar
• Gobinath, D., A. N. Madhu, G. Prashant, K. Srinivasan, and S. G. Prapulla. 2010. Beneficial effect of xylo-oligosaccharides and fructo-oligosaccharides in streptozotocin-induced diabetic rats. British Journal of Nutrition 104 (1):40–7. doi: 10.1017/S0007114510000243.
   PubMed Web of Science ®Google Scholar
• Grassi, F., A. M. Tyagi, J. W. Calvert, L. Gambari, L. D. Walker, M. Yu, J. Robinson, J.-Y. Li, G. Lisignoli, C. Vaccaro, et al. 2016. Hydrogen sulfide is a novel regulator of bone formation implicated in the bone loss induced by estrogen deficiency. Journal of Bone and Mineral Research 31 (5):949–63.
   PubMed Web of Science ®Google Scholar
• Greer, R. L., X. Dong, A. C. F. Moraes, R. A. Zielke, G. R. Fernandes, E. Peremyslova, S. Vasquez-Perez, A. A. Schoenborn, E. P. Gomes, A. C. Pereira, et al. 2016. Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism. Nature Communications 7:13329.
   PubMed Web of Science ®Google Scholar
• Griffin, M. D., T. A. Sanders, I. G. Davies, L. M. Morgan, D. J. Millward, F. Lewis, S. Slaughter, J. A. Cooper, G. J. Miller, and B. A. Griffin. 2006. Effects of altering the ratio of dietary n− 6 to n− 3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45–70 y: The OPTILIP Study. The American Journal of Clinical Nutrition 84 (6):1290–8. doi: 10.1093/ajcn/84.6.1290.
   PubMed Web of Science ®Google Scholar
• Guevara-Cruz, M., E. T. Godinez-Salas, M. Sanchez-Tapia, G. Torres-Villalobos, E. Pichardo-Ontiveros, R. Guizar-Heredia, L. Arteaga-Sanchez, G. Gamba, R. Mojica-Espinosa, A. Schcolnik-Cabrera, et al. 2020. Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects. BMJ Open Diabetes Research & Care 8 (1):e000948. doi: 10.1136/bmjdrc-2019-000948.
   PubMed Web of Science ®Google Scholar
• Guo, T., D. Song, L. Cheng, and X. Zhang. 2019. Interactions of tea catechins with intestinal microbiota and their implication for human health. Food Science and Biotechnology 28 (6):1617–25.
   PubMed Web of Science ®Google Scholar
• Gurung, M., Z. Li, H. You, R. Rodrigues, D. B. Jump, A. Morgun, and N. Shulzhenko. 2020. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine 51:102590.
   PubMed Web of Science ®Google Scholar
• Hannan, J. M. A., L. Ali, B. Rokeya, J. Khaleque, M. Akhter, P. R. Flatt, and Y. H. A. Abdel-Wahab. 2007. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. British Journal of Nutrition 97 (3):514–21. doi: 10.1017/S0007114507657869.
   PubMed Web of Science ®Google Scholar
• Heianza, Y., Y. Arase, S. Kodama, S. D. Hsieh, H. Tsuji, K. Saito, H. Shimano, S. Hara, and H. Sone. 2013. Effect of postmenopausal status and age at menopause on type 2 diabetes and prediabetes in Japanese individuals: Toranomon Hospital Health Management Center Study 17 (TOPICS 17). Diabetes Care 36 (12):4007–14. doi: 10.2337/dc13-1048.
   PubMed Web of Science ®Google Scholar
• Hevener, A. L., V. Ribas, T. M. Moore, and Z. Zhou. 2020. The impact of skeletal muscle ERα on mitochondrial function and metabolic health. Endocrinology 161 (2):1–16. doi: 10.1210/endocr/bqz017.
   Web of Science ®Google Scholar
• Hope, S. 2016. The NICE menopause guidelines. Maturitas 85:71–2.
   PubMed Web of Science ®Google Scholar
• Hsieh, M.-C., W.-H. Tsai, Y.-P. Jheng, S.-L. Su, S.-Y. Wang, C.-C. Lin, Y.-H. Chen, and W.-W. Chang. 2018. The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: A randomized, double-blinded, placebo-controlled trial. Scientific Reports 8 (1):16791. doi: 10.1038/s41598-018-35014-1.
   PubMedGoogle Scholar
• Hsieh, P.-S., H.-H. Ho, S.-H. Hsieh, Y.-W. Kuo, H.-Y. Tseng, H.-F. Kao, and J.-Y. Wang. 2020. Lactobacillus salivarius AP-32 and Lactobacillus reuteri GL-104 decrease glycemic levels and attenuate diabetes-mediated liver and kidney injury in db/db mice. BMJ Open Diabetes Research & Care 8 (1):e001028. doi: 10.1136/bmjdrc-2019-001028.
   PubMed Web of Science ®Google Scholar
• Janeiro, M. H., M. J. Ramírez, F. I. Milagro, J. A. Martínez, and M. Solas. 2018. Implication of trimethylamine N-oxide (TMAO) in disease: Potential biomarker or new therapeutic target. Nutrients 10 (10):1398. doi: 10.3390/nu10101398.
   PubMed Web of Science ®Google Scholar
• Jang, A.-R., J.-S. Park, D.-K. Kim, J.-Y. Park, J.-H. Ahn, D.-Y. Kim, T.-S. Lee, J.-Y. Chang, J.-H. Choi, and J.-H. Park. 2021. Cell-free culture supernatant of Lactobacillus curvatus Wikim38 inhibits RANKL-induced osteoclast differentiation and ameliorates bone loss in ovariectomized mice. Letters in Applied Microbiology 73 (3):383–91. doi: 10.1111/lam.13525.
   PubMed Web of Science ®Google Scholar
• Jang, H. R., and H.-Y. Lee. 2021. Mechanisms linking gut microbial metabolites to insulin resistance. World Journal of Diabetes 12 (6):730–44.
   PubMed Web of Science ®Google Scholar
• Jeon, S.-M. 2016. Regulation and function of AMPK in physiology and diseases. Experimental & Molecular Medicine 48 (7):e245. doi: 10.1038/emm.2016.81.
   PubMed Web of Science ®Google Scholar
• Jeong, S.-Y., S. Kang, C. S. Hua, Z. Ting, and S. Park. 2017. Synbiotic effects of β-glucans from cauliflower mushroom and Lactobacillus fermentum on metabolic changes and gut microbiome in estrogen-deficient rats. Genes & Nutrition 12:31. doi: 10.1186/s12263-017-0585-z.
   PubMed Web of Science ®Google Scholar
• Jia, L., D. Li, N. Feng, M. Shamoon, Z. Sun, L. Ding, H. Zhang, W. Chen, J. Sun, and Y. Q. Chen. 2017. Anti-diabetic effects of Clostridium butyricum CGMCC0313.1 through promoting the growth of gut butyrate-producing bacteria in type 2 diabetic mice. Scientific Reports 7:1–15.
   PubMed Web of Science ®Google Scholar
• Joon Cho, G., J. Hyun Lee, H. Tae Park, J. Ho Shin, S. Cheol Hong, T. Kim, J. Young Hur, K. Wan Lee, Y. Kyun Park, and S. Haeng Kim. 2008. Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome. Menopause 15 (3):524–9. doi: 10.1097/gme.0b013e3181559860.
   PubMed Web of Science ®Google Scholar
• Kalaycıoğlu, Z., I. Gazioğlu, and F. B. Erim. 2017. Comparison of antioxidant, anticholinesterase, and antidiabetic activities of three curcuminoids isolated from Curcuma longa L. Natural Product Research 31 (24):2914–7.
   PubMed Web of Science ®Google Scholar
• Kaliannan, K., R. C. Robertson, K. Murphy, C. Stanton, C. Kang, B. Wang, L. Hao, A. K. Bhan, and J. X. Kang. 2018. Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice. Microbiome 6 (1):205. doi: 10.1186/s40168-018-0587-0.
   PubMed Web of Science ®Google Scholar
• Kanmani, S., M. Kwon, M.-K. Shin, and M. K. Kim. 2019. Association of C-reactive protein with risk of developing type 2 diabetes mellitus, and role of obesity and hypertension: A large population-based Korean cohort study. Scientific Reports 9 (1):1–8. doi: 10.1038/s41598-019-40987-8.
   PubMedGoogle Scholar
• Kay, B. A., K. Trigatti, M. B. MacNeil, S. L. Klingel, N. Repin, H. D. Goff, A. J. Wright, and A. M. Duncan. 2017. Pudding products enriched with yellow mustard mucilage, fenugreek gum or flaxseed mucilage and matched for simulated intestinal viscosity significantly reduce postprandial peak glucose and insulin in adults at risk for type 2 diabetes. Journal of Functional Foods 37:603–11. doi: 10.1016/j.jff.2017.08.017.
   Web of Science ®Google Scholar
• Kikuchi, K., M. Ben Othman, and K. Sakamoto. 2018. Sterilized bifidobacteria suppressed fat accumulation and blood glucose level. Biochemical and Biophysical Research Communications 501 (4):1041–7.
   PubMed Web of Science ®Google Scholar
• Kim, S.-H., C.-S. Huh, I.-D. Choi, J.-W. Jeong, H.-K. Ku, J.-H. Ra, T.-Y. Kim, G.-B. Kim, J.-H. Sim, and Y.-T. Ahn. 2014. The anti-diabetic activity of Bifidobacterium lactis HY8101 in vitro and in vivo. Journal of Applied Microbiology 117 (3):834–45.
   PubMed Web of Science ®Google Scholar
• Kim, Y. A., J. B. Keogh, and P. M. Clifton. 2018. Probiotics, prebiotics, synbiotics and insulin sensitivity. Nutrition Research Reviews 31 (1):35–51.
   PubMed Web of Science ®Google Scholar
• Ko, S.-H., and H.-S. Kim. 2020. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients 12 (1):202. doi: 10.3390/nu12010202.
   PubMed Web of Science ®Google Scholar
• Kocsis, T., B. Molnár, D. Németh, P. Hegyi, Z. Szakács, A. Bálint, A. Garami, A. Soós, K. Márta, and M. Solymár. 2020. Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: A meta-analysis of randomized clinical trials. Scientific Reports 10 (1):11787. doi: 10.1038/s41598-020-68440-1.
   PubMed Web of Science ®Google Scholar
• Kommoju, U. J., and B. M. Reddy. 2011. Genetic etiology of type 2 diabetes mellitus: A review. International Journal of Diabetes in Developing Countries 31 (2):51–64. doi: 10.1007/s13410-011-0020-8.
   Web of Science ®Google Scholar
• Koye, D. N., D. J. Magliano, R. G. Nelson, and M. E. Pavkov. 2018. The global epidemiology of diabetes and kidney disease. Advances in Chronic Kidney Disease 25 (2):121–32.
   PubMed Web of Science ®Google Scholar
• Kumar, G. S., A. Shetty, and P. Salimath. 2005. Modulatory effect of fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases in streptozotocin induced diabetic rats. Plant Foods for Human Nutrition 60 (2):87–91.
   PubMed Web of Science ®Google Scholar
• Kwa, M., C. S. Plottel, M. J. Blaser, and S. Adams. 2016. The intestinal microbiome and estrogen receptor–positive female breast cancer. JNCI: Journal of the National Cancer Institute 108 (8):djw029.
   PubMedGoogle Scholar
• Lee, H., G. Ko, and M. W. Griffiths. 2014. Effect of metformin on metabolic improvement and gut microbiota. Applied and Environmental Microbiology 80 (19):5935–43.
   PubMed Web of Science ®Google Scholar
• Lee, S. H., H. S. You, H.-G. Kang, S. S. Kang, and S. H. Hyun. 2020. Association between altered blood parameters and gut microbiota after synbiotic intake in healthy. Elderly Korean Women. Nutrients 12:3112.
   Google Scholar
• Legry, V., S. Francque, J. T. Haas, A. Verrijken, S. Caron, O. Chávez-Talavera, E. Vallez, L. Vonghia, E. Dirinck, A. Verhaegen, et al. 2017. Bile acid alterations are associated with insulin resistance, but not with NASH, in obese subjects. The Journal of Clinical Endocrinology & Metabolism 102 (10):3783–94. doi: 10.1210/jc.2017-01397.
   PubMed Web of Science ®Google Scholar
• Lei, Z., H. Wu, Y. Yang, Q. Hu, Y. Lei, W. Liu, Y. Nie, L. Yang, X. Zhang, C. Yang, et al. 2021. Ovariectomy impaired hepatic glucose and lipid homeostasis and altered the gut microbiota in mice with different diets. Frontiers in Endocrinology 12:708838. doi: 10.3389/fendo.2021.708838.
   PubMed Web of Science ®Google Scholar
• Lekshmi, P. C., R. Arimboor, K. G. Raghu, and A. N. Menon. 2012. Turmerin, the antioxidant protein from turmeric (Curcuma longa) exhibits antihyperglycaemic effects. Natural Product Research 26 (17):1654–8.
   PubMed Web of Science ®Google Scholar
• Lett, A. M., P. S. Thondre, and A. J. Rosenthal. 2013. Yellow mustard bran attenuates glycaemic response of a semi-solid food in young healthy men. International Journal of Food Sciences and Nutrition 64 (2):140–6. doi: 10.3109/09637486.2012.728201.
   PubMed Web of Science ®Google Scholar
• Li, K.-K., P.-J. Tian, S.-D. Wang, P. Lei, L. Qu, J.-P. Huang, Y.-J. Shan, and B-l. Li. 2017. Targeting gut microbiota: Lactobacillus alleviated type 2 diabetes via inhibiting LPS secretion and activating GPR43 pathway. Journal of Functional Foods 38:561–70. doi: 10.1016/j.jff.2017.09.049.
   Web of Science ®Google Scholar
• Liang, H., X. Chen, Q. Chen, Y. Wang, X. Wu, Y. Li, B. Pan, H. Liu, and M. Li. 2013. The metabolic syndrome among postmenopausal women in rural Canton: Prevalence, associated factors, and the optimal obesity and atherogenic indices. PLoS One 8 (9):e74121. doi: 10.1371/journal.pone.0074121.
   PubMed Web of Science ®Google Scholar
• Liou, C. S., S. J. Sirk, C. A. C. Diaz, A. P. Klein, C. R. Fischer, S. K. Higginbottom, A. Erez, M. S. Donia, J. L. Sonnenburg, and E. S. Sattely. 2020. A metabolic pathway for activation of dietary glucosinolates by a human gut symbiont. Cell 180 (4):717–28.e19. doi: 10.1016/j.cell.2020.01.023.
   PubMed Web of Science ®Google Scholar
• Lisabeth, L., and C. Bushnell. 2012. Stroke risk in women: The role of menopause and hormone therapy. The Lancet. Neurology 11 (1):82–91.
   PubMed Web of Science ®Google Scholar
• Liu, G., J. Bei, L. Liang, G. Yu, L. Li, and Q. Li. 2018. Stachyose improves inflammation through modulating gut microbiota of high-fat diet/streptozotocin-induced type 2 diabetes in rats. Molecular Nutrition & Food Research 62 (6):1700954. doi: 10.1002/mnfr.201700954.
   PubMed Web of Science ®Google Scholar
• Liu, Y., Y.-L. Guo, S. Meng, H. Gao, L.-J. Sui, S. Jin, Y. Li, and S.-G. Fan. 2020. Gut microbiota-dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: A matched case-control study. Aging 12 (11):10633–41. doi: 10.18632/aging.103283.
   PubMedGoogle Scholar
• Lobo, R. A., S. R. Davis, T. J. De Villiers, A. Gompel, V. W. Henderson, H. N. Hodis, M. A. Lumsden, W. J. Mack, S. Shapiro, and R. J. Baber. 2014. Prevention of diseases after menopause. Climacteric 17 (5):540–56. doi: 10.3109/13697137.2014.933411.
   PubMed Web of Science ®Google Scholar
• Louis, P., and H. J. Flint. 2017. Formation of propionate and butyrate by the human colonic microbiota. Environmental Microbiology 19 (1):29–41. doi: 10.1111/1462-2920.13589.
   PubMed Web of Science ®Google Scholar
• Lucas, S., Y. Omata, J. Hofmann, M. Böttcher, A. Iljazovic, K. Sarter, O. Albrecht, O. Schulz, B. Krishnacoumar, G. Krönke, et al. 2018. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications 9 (1):55.
   PubMedGoogle Scholar
• Lukovac, S., C. Belzer, L. Pellis, B. J. Keijser, W. M. de Vos, R. C. Montijn, and G. Roeselers. 2014. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids. mBio 5 (4):e01438-14. doi: 10.1128/mBio.01438-14.
   PubMed Web of Science ®Google Scholar
• Luo, J., Y. Li, Y. Mai, L. Gao, S. Ou, Y. Wang, L. Liu, and X. Peng. 2018. Flaxseed gum reduces body weight by regulating gut microbiota. Journal of Functional Foods 47:136–42. doi: 10.1016/j.jff.2018.05.042.
   Web of Science ®Google Scholar
• Luo, J., M. Van Yperselle, S. W. Rizkalla, F. Rossi, F. R. J. Bornet, and G. Slama. 2000. Chronic consumption of short-chain fructooligosaccharides does not affect basal hepatic glucose production or insulin resistance in type 2 diabetics. The Journal of Nutrition 130 (6):1572–7. doi: 10.1093/jn/130.6.1572.
   PubMed Web of Science ®Google Scholar
• Ma, H.-r., J. Wang, H.-x. Qi, Y.-h. Gao, L.-j. Pang, Y. Yang, Z.-h. Wang, M.-j. Duan, H. Chen, X. Cao, et al. 2013. Assessment of the estrogenic activities of chickpea (Cicer arietinum L) sprout isoflavone extract in ovariectomized rats. Acta Pharmacologica Sinica 34 (3):380–6.
   PubMed Web of Science ®Google Scholar
• Marchand, G. B., A.-M. Carreau, S. J. Weisnagel, J. Bergeron, F. Labrie, S. Lemieux, and A. Tchernof. 2018. Increased body fat mass explains the positive association between circulating estradiol and insulin resistance in postmenopausal women. American Journal of Physiology-Endocrinology and Metabolism 314 (5):E448–E456. doi: 10.1152/ajpendo.00293.2017.
   PubMed Web of Science ®Google Scholar
• Marco, M. L., D. Heeney, S. Binda, C. J. Cifelli, P. D. Cotter, B. Foligné, M. Gänzle, R. Kort, G. Pasin, A. Pihlanto, et al. 2017. Health benefits of fermented foods: Microbiota and beyond. Current Opinion in Biotechnology 44:94–102.
   PubMed Web of Science ®Google Scholar
• Martin, A. M., J. M. Yabut, J. M. Choo, A. J. Page, E. W. Sun, C. F. Jessup, S. L. Wesselingh, W. I. Khan, G. B. Rogers, G. R. Steinberg, et al. 2019. The gut microbiome regulates host glucose homeostasis via peripheral serotonin. Proceedings of the National Academy of Sciences of the United States of America 116:19802.
   PubMed Web of Science ®Google Scholar
• Masala, G., B. Bendinelli, C. D. Bella, M. Assedi, S. Tapinassi, I. Ermini, D. Occhini, M. Castaldo, C. Saieva, S. Caini, et al. 2020. Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women. Scientific Reports 10 (1):21845. doi: 10.1038/s41598-020-78796-z.
   PubMed Web of Science ®Google Scholar
• Mauvais-Jarvis, F., J. E. Manson, J. C. Stevenson, and V. A. Fonseca. 2017. Menopausal hormone therapy and type 2 diabetes prevention: Evidence, mechanisms, and clinical implications. Endocrine Reviews 38 (3):173–88.
   PubMed Web of Science ®Google Scholar
• Mayneris-Perxachs, J., M. Arnoriaga-Rodríguez, D. Luque-Córdoba, F. Priego-Capote, V. Pérez-Brocal, A. Moya, A. Burokas, R. Maldonado, and J.-M. Fernández-Real. 2020. Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: Influences of obesity and menopausal status. Microbiome 8 (1):136. doi: 10.1186/s40168-020-00913-x.
   PubMed Web of Science ®Google Scholar
• Mirmiranpour, H., H. F. Huseini, H. Derakhshanian, Z. Khodaii, and B. Tavakoli-Far. 2020. Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study. Journal of Diabetes and Metabolic Disorders 19 (1):53–60.
   PubMed Web of Science ®Google Scholar
• Molehin, O. R. S. A. Adefegha, and A. A. Adeyanju. 2020. Role of oxidative stress in the pathophysiology of type 2 diabetes and cardiovascular diseases. In Role of oxidative stress in pathophysiology of diseases, ed. P. K. Maurya and K. Dua, 277–97. Singapore: Springer.
   Google Scholar
• Molinaro, A., A. Wahlström, and H.-U. Marschall. 2018. Role of bile acids in metabolic control. Trends in Endocrinology and Metabolism 29 (1):31–41. doi: 10.1016/j.tem.2017.11.002.
   PubMed Web of Science ®Google Scholar
• Montazeri-Najafabady, N., Y. Ghasemi, M. H. Dabbaghmanesh, Y. Ashoori, P. Talezadeh, F. Koohpeyma, S. N. Abootalebi, and A. Gholami. 2021. Exploring the bone sparing effects of postbiotics in the post-menopausal rat model. BMC Complementary Medicine and Therapies 21 (1):155.
   PubMedGoogle Scholar
• Moroti, C., L. F. Souza Magri, M. de Rezende Costa, D. C. U. Cavallini, and K. Sivieri. 2012. Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids in Health and Disease 11 (1):29. doi: 10.1186/1476-511X-11-29.
   PubMedGoogle Scholar
• Moulton, V. R. 2018. Sex hormones in acquired immunity and autoimmune disease. Frontiers in Immunology 9:2279. doi: 10.3389/fimmu.2018.02279.
   PubMed Web of Science ®Google Scholar
• Mtintsilana, A., L. K. Micklesfield, E. Chorell, T. Olsson, and J. H. Goedecke. 2019. Fat redistribution and accumulation of visceral adipose tissue predicts type 2 diabetes risk in middle-aged black South African women: A 13-year longitudinal study. Nutrition & Diabetes 9 (1):12. doi: 10.1038/s41387-019-0079-8.
   PubMedGoogle Scholar
• Navarro del Hierro, J., C. Cueva, A. Tamargo, E. Núñez-Gómez, M. V. Moreno-Arribas, G. Reglero, and D. Martin. 2020. In vitro colonic fermentation of saponin-rich extracts from quinoa, lentil, and fenugreek. Effect on sapogenins yield and human gut microbiota. Journal of Agricultural and Food Chemistry 68 (1):106–16.
   PubMed Web of Science ®Google Scholar
• Nie, Q., H. Chen, J. Hu, S. Fan, and S. Nie. 2019. Dietary compounds and traditional Chinese medicine ameliorate type 2 diabetes by modulating gut microbiota. Critical Reviews in Food Science and Nutrition 59 (6):848–63.
   PubMed Web of Science ®Google Scholar
• Niness, K. R. 1999. Inulin and oligofructose: What are they? The Journal of Nutrition 129 (7):1402S–6S. doi: 10.1093/jn/129.7.1402S.
   PubMed Web of Science ®Google Scholar
• Norris, L. E., A. L. Collene, M. L. Asp, J. C. Hsu, L.-F. Liu, J. R. Richardson, D. Li, D. Bell, K. Osei, R. D. Jackson, et al. 2009. Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. The American Journal of Clinical Nutrition 90 (3):468–76.
   PubMed Web of Science ®Google Scholar
• Ozaki, D., R. Kubota, T. Maeno, M. Abdelhakim, and N. Hitosugi. 2021. Association between gut microbiota, bone metabolism, and fracture risk in postmenopausal Japanese women. Osteoporosis International 32 (1):145–56.
   PubMed Web of Science ®Google Scholar
• Petrine, J. C. P., and B. D. Bianco-Borges. 2021. The influence of phytoestrogens on different physiological and pathological processes: An overview. Phytotherapy Research 35 (1):180–97.
   PubMed Web of Science ®Google Scholar
• Pivari, F., A. Mingione, C. Brasacchio, and L. Soldati. 2019. Curcumin and type 2 diabetes mellitus: Prevention and treatment. Nutrients 11 (8):1837. doi: 10.3390/nu11081837.
   PubMed Web of Science ®Google Scholar
• Pu, D., R. Tan, Q. Yu, and J. Wu. 2017. Metabolic syndrome in menopause and associated factors: A meta-analysis. Climacteric 20 (6):583–91.
   PubMed Web of Science ®Google Scholar
• Qureshi, R., M. Picon-Ruiz, I. Aurrekoetxea-Rodriguez, V. Nunes de Paiva, M. D’Amico, H. Yoon, R. Radhakrishnan, C. Morata-Tarifa, T. Ince, M. E. Lippman, et al. 2020. The major pre- and postmenopausal estrogens play opposing roles in obesity-driven mammary inflammation and breast cancer development. Cell Metabolism 31 (6):1154–72.e9. doi: 10.1016/j.cmet.2020.05.008.
   PubMed Web of Science ®Google Scholar
• Raji Lahiji, M., S. Najafi, L. Janani, B. Yazdani, E. Razmpoosh, and M. Zarrati. 2021. The effect of synbiotic on glycemic profile and sex hormones in overweight and obese breast cancer survivors following a weight-loss diet: A randomized, triple-blind, controlled trial. Clinical Nutrition 40 (2):394–403. doi: 10.1016/j.clnu.2020.05.043.
   PubMed Web of Science ®Google Scholar
• Ren, Y., M. Zhang, Y. Liu, X. Sun, B. Wang, Y. Zhao, D. Liu, X. Liu, D. Zhang, F. Liu, et al. 2019. Association of menopause and type 2 diabetes mellitus. Menopause 26 (3):325–30.
   PubMed Web of Science ®Google Scholar
• Rettedal, E. A., B. L. Ilesanmi-Oyelere, N. C. Roy, J. Coad, and M. C. Kruger. 2021. The gut microbiome is altered in postmenopausal women with osteoporosis and osteopenia. JBMR Plus 5 (3):e10452.
   PubMedGoogle Scholar
• Ridlon, J. M., D. J. Kang, P. B. Hylemon, and J. S. Bajaj. 2014. Bile acids and the gut microbiome. Current Opinion in Gastroenterology 30 (3):332–8.
   PubMed Web of Science ®Google Scholar
• Rios-Covian, D., N. Salazar, M. Gueimonde, and C. G. de los Reyes-Gavilan. 2017. Shaping the metabolism of intestinal bacteroides population through diet to improve human health. Frontiers in Microbiology 8:376. doi: 10.3389/fmicb.2017.00376.
   PubMed Web of Science ®Google Scholar
• Rivière, A., M. Selak, D. Lantin, F. Leroy, and L. D. Vuyst. 2016. Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. Frontiers in Microbiology 7:979. doi: 10.3389/fmicb.2016.00979.
   PubMed Web of Science ®Google Scholar
• Roberts, K. T. 2011. The potential of fenugreek (Trigonella foenum-graecum) as a functional food and nutraceutical and its effects on glycemia and lipidemia. Journal of Medicinal Food 14 (12):1485–9.
   PubMed Web of Science ®Google Scholar
• Rosano, G. M. C., C. Vitale, G. Marazzi, and M. Volterrani. 2007. Menopause and cardiovascular disease: The evidence. Climacteric 10 (sup1):19–24. doi: 10.1080/13697130601114917.
   PubMed Web of Science ®Google Scholar
• Sáez-Lara, M. J., C. Robles-Sanchez, F. J. Ruiz-Ojeda, J. Plaza-Diaz, and A. Gil. 2016. Effects of probiotics and synbiotics on obesity, insulin resistance syndrome, type 2 diabetes and non-alcoholic fatty liver disease: A review of human clinical trials. International Journal of Molecular Sciences 17 (6):928. doi: 10.3390/ijms17060928.
   PubMed Web of Science ®Google Scholar
• Sanborn, V. E., M. A. Azcarate-Peril, and J. Gunstad. 2020. Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary randomized study. Diabetes & Metabolic Syndrome 14 (5):907–9.
   PubMed Web of Science ®Google Scholar
• Santos-Marcos, J. A., O. A. Rangel-Zuñiga, R. Jimenez-Lucena, G. M. Quintana-Navarro, S. Garcia-Carpintero, M. M. Malagon, B. B. Landa, M. Tena-Sempere, P. Perez-Martinez, J. Lopez-Miranda, et al. 2018. Influence of gender and menopausal status on gut microbiota. Maturitas 116:43–53.
   PubMed Web of Science ®Google Scholar
• Schreurs, M. P. H., P. J. de Vos van Steenwijk, A. Romano, S. Dieleman, and H. M. J. Werner. 2021. How the gut microbiome links to menopause and obesity, with possible implications for endometrial cancer development. Journal of Clinical Medicine 10 (13):2916. doi: 10.3390/jcm10132916.
   PubMed Web of Science ®Google Scholar
• Shafi, A., H. Naeem Raja, U. Farooq, K. Akram, Z. Hayat, A. Naz, and H. R. Nadeem. 2019. Antimicrobial and antidiabetic potential of synbiotic fermented milk: A functional dairy product. International Journal of Dairy Technology 72 (1):15–22. doi: 10.1111/1471-0307.12555.
   Web of Science ®Google Scholar
• Shakeri, H., H. Hadaegh, F. Abedi, M. Tajabadi-Ebrahimi, N. Mazroii, Y. Ghandi, and Z. Asemi. 2014. Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes. Lipids 49 (7):695–701.
   PubMed Web of Science ®Google Scholar
• Shieh, A., M. Epeldegui, A. S. Karlamangla, and G. A. Greendale. 2020. Gut permeability, inflammation, and bone density across the menopause transition. JCI Insight 5 (2):e134092. doi: 10.1172/jci.insight.134092.
   PubMed Web of Science ®Google Scholar
• Shoff, S. M., P. A. Newcomb, J. A. Mares‐Perlman, B. E. K. Klein, S. M. Haffner, B. E. Storer, and R. Klein. 1998. Usual consumption of plant foods containing phytoestrogens and sex hormone levels in postmenopausal women in Wisconsin. Nutrition and Cancer 30 (3):207–12.
   PubMed Web of Science ®Google Scholar
• Shtriker, M. G., M. Hahn, E. Taieb, A. Nyska, U. Moallem, O. Tirosh, and Z. Madar. 2018. Fenugreek galactomannan and citrus pectin improve several parameters associated with glucose metabolism and modulate gut microbiota in mice. Nutrition 46:134–42.e3. doi: 10.1016/j.nut.2017.07.012.
   PubMed Web of Science ®Google Scholar
• Skrypnik, K., P. Bogdański, M. Sobieska, and J. Suliburska. 2019. The effect of multistrain probiotic supplementation in two doses on iron metabolism in obese postmenopausal women: A randomized trial. Food & Function 10 (8):5228–38.
   PubMed Web of Science ®Google Scholar
• Soltanian, N., and M. Janghorbani. 2018. A randomized trial of the effects of flaxseed to manage constipation, weight, glycemia, and lipids in constipated patients with type 2 diabetes. Nutrition & Metabolism 15 (1):1–9. doi: 10.1186/s12986-018-0273-z.
   PubMedGoogle Scholar
• Song, Y., N. R. Cook, C. M. Albert, M. Van Denburgh, and J. E. Manson. 2009. Effects of vitamins C and E and β-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: A randomized controlled trial. The American Journal of Clinical Nutrition 90 (2):429–37. doi: 10.3945/ajcn.2009.27491.
   PubMed Web of Science ®Google Scholar
• Soukoulis, C., C. Gaiani, and L. Hoffmann. 2018. Plant seed mucilage as emerging biopolymer in food industry applications. Current Opinion in Food Science 22:28–42. doi: 10.1016/j.cofs.2018.01.004.
   Web of Science ®Google Scholar
• Sowbhagya, H. 2019. Value-added processing of by-products from spice industry. Food Quality and Safety 3 (2):73–80. doi: 10.1093/fqsafe/fyy029.
   Web of Science ®Google Scholar
• Spranger, J., A. Kroke, M. Möhlig, K. Hoffmann, M. M. Bergmann, M. Ristow, H. Boeing, and A. F. H. Pfeiffer. 2003. Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetes 52 (3):812–7. doi: 10.2337/diabetes.52.3.812.
   PubMed Web of Science ®Google Scholar
• Stachowiak, G., T. Pertyński, and M. Pertyńska-Marczewska. 2015. Metabolic disorders in menopause. Przeglad Menopauzalny = Menopause Review 14 (1):59–64.
   PubMedGoogle Scholar
• Stojanov, S., and S. Kreft. 2020. Gut microbiota and the metabolism of phytoestrogens. Revista Brasileira de Farmacognosia 30 (2):145–54. doi: 10.1007/s43450-020-00049-x.
   Google Scholar
• Straub, R. H. 2007. The complex role of estrogens in inflammation. Endocrine Reviews 28 (5):521–74.
   PubMed Web of Science ®Google Scholar
• Szulińska, M., I. Łoniewski, S. Van Hemert, M. Sobieska, and P. Bogdański. 2018. Dose-dependent effects of multispecies probiotic supplementation on the lipopolysaccharide (LPS) level and cardiometabolic profile in obese postmenopausal women: A 12-week randomized clinical trial. Nutrients 10 (6):773. doi: 10.3390/nu10060773.
   PubMed Web of Science ®Google Scholar
• Takahashi, M., M. Miyashita, K. Suzuki, S-r. Bae, H.-K. Kim, T. Wakisaka, Y. Matsui, M. Takeshita, and K. Yasunaga. 2014. Acute ingestion of catechin-rich green tea improves postprandial glucose status and increases serum thioredoxin concentrations in postmenopausal women. British Journal of Nutrition 112 (9):1542–50. doi: 10.1017/S0007114514002530.
   PubMed Web of Science ®Google Scholar
• Tamargo, A., C. Cueva, L. Laguna, M. V. Moreno-Arribas, and L. A. Muñoz. 2018. Understanding the impact of chia seed mucilage on human gut microbiota by using the dynamic gastrointestinal model simgi®. Journal of Functional Foods 50:104–11. doi: 10.1016/j.jff.2018.09.028.
   Web of Science ®Google Scholar
• Tao, Y.-W., Y.-L. Gu, X.-Q. Mao, L. Zhang, and Y.-F. Pei. 2020. Effects of probiotics on type II diabetes mellitus: A meta-analysis. Journal of Translational Medicine 18 (1):30. doi: 10.1186/s12967-020-02213-2.
   PubMed Web of Science ®Google Scholar
• Tardivo, A. P., J. Nahas-Neto, C. L. Orsatti, F. B. Dias, P. F. Poloni, E. B. Schmitt, and E. A. P. Nahas. 2015. Effects of omega-3 on metabolic markers in postmenopausal women with metabolic syndrome. Climacteric 18 (2):290–8. doi: 10.3109/13697137.2014.981521.
   PubMed Web of Science ®Google Scholar
• Tavakoly, R., M. R. Maracy, M. Karimifar, and M. H. Entezari. 2018. Does fenugreek (Trigonella foenum-graecum) seed improve inflammation, and oxidative stress in patients with type 2 diabetes mellitus? A parallel group randomized clinical trial. European Journal of Integrative Medicine 18:13–7. doi: 10.1016/j.eujim.2018.01.005.
   Web of Science ®Google Scholar
• Taylor, D. R., J. Alaghband-Zadeh, G. F. Cross, S. Omar, C. W. Le Roux, and R. P. Vincent. 2014. Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2. PLoS One. 9 (4):e93540. doi: 10.1371/journal.pone.0093540.
   PubMed Web of Science ®Google Scholar
• Taylor, R. 2013. Type 2 diabetes: Etiology and reversibility. Diabetes Care 36 (4):1047–55.
   PubMed Web of Science ®Google Scholar
• Timan, P., N. Rojanasthien, M. Manorot, C. Sangdee, and S. Teekachunhatean. 2014. Effect of synbiotic fermented milk on oral bioavailability of isoflavones in postmenopausal women. International Journal of Food Sciences and Nutrition 65 (6):761–7.
   PubMed Web of Science ®Google Scholar
• Tu, M.-Y. K.-Y. Han, G. R. Chang, G.-D. Lai, K.-Y. Chang, C.-F. Chen, J.-C. Lai, C.-Y. Lai, H.-L. Chen, and C.-M. Chen. 2020. Kefir peptides prevent estrogen deficiency-induced bone loss and modulate the structure of the gut microbiota in ovariectomized mice. Nutrients 12 (11):3432. doi: 10.3390/nu12113432.
   Google Scholar
• Valdes, A. M., J. Walter, E. Segal, and T. D. Spector. 2018. Role of the gut microbiota in nutrition and health. BMJ 361:k2179.
   PubMedGoogle Scholar
• Velayati, A., I. Kareem, M. Sedaghat, G. Sohrab, O. Nikpayam, M. Hedayati, K. Abhari, and E. Hejazi. 2021. Does symbiotic supplementation which contains Bacillus coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial. Archives of Physiology and Biochemistry 1–8. doi: 10.1080/13813455.2021.1928225.
   PubMed Web of Science ®Google Scholar
• Vieira, A. T., P. M. Castelo, D. A. Ribeiro, and C. M. Ferreira. 2017. Influence of oral and gut microbiota in the health of menopausal women. Frontiers in Microbiology 8:1884. doi: 10.3389/fmicb.2017.01884.
   PubMed Web of Science ®Google Scholar
• Wan, M. L. Y., V. A. Co, and H. El-Nezami. 2021. Dietary polyphenol impact on gut health and microbiota. Critical Reviews in Food Science and Nutrition 61 (4):690–711.
   PubMed Web of Science ®Google Scholar
• Wang, G., X. Li, J. Zhao, H. Zhang, and W. Chen. 2017. Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism. Food & Function 8 (9):3155–64. doi: 10.1039/C7FO00593H.
   PubMed Web of Science ®Google Scholar
• Wang, J., W. Xu, R. Wang, R. Cheng, Z. Tang, and M. Zhang. 2021. The outer membrane protein Amuc_1100 of Akkermansia muciniphila promotes intestinal 5-HT biosynthesis and extracellular availability through TLR2 signalling. Food & Function 12 (8):3597–610.
   PubMed Web of Science ®Google Scholar
• Wang, L., X. Yu, X. Xu, J. Ming, Z. Wang, B. Gao, Y. Xing, J. Zhou, J. Fu, T. Liu, et al. 2021. The fecal microbiota is already altered in normoglycemic individuals who go on to have type 2 diabetes. Frontiers in Cellular and Infection Microbiology 11:598672. doi: 10.3389/fcimb.2021.598672.
   PubMed Web of Science ®Google Scholar
• Wang, M., F. Gorelick, and A. Bhargava. 2021. Sex differences in the exocrine pancreas and associated diseases. Cellular and Molecular Gastroenterology and Hepatology 12 (2):427–41. doi: 10.1016/j.jcmgh.2021.04.005.
   PubMed Web of Science ®Google Scholar
• Wang, S., Y. Xiao, F. Tian, J. Zhao, H. Zhang, Q. Zhai, and W. Chen. 2020. Rational use of prebiotics for gut microbiota alterations: Specific bacterial phylotypes and related mechanisms. Journal of Functional Foods 66:103838. doi: 10.1016/j.jff.2020.103838.
   Web of Science ®Google Scholar
• Watanabe, H., M. T. Rose, and H. Aso. 2011. Role of peripheral serotonin in glucose and lipid metabolism. Current Opinion in Lipidology 22 (3):186–91.
   PubMed Web of Science ®Google Scholar
• Won, G., S.-I. Choi, N. Park, J.-E. Kim, C.-H. Kang, and G.-H. Kim. 2021. In vitro antidiabetic, antioxidant activity, and probiotic activities of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei strains. Current Microbiology 78 (8):3181–91.
   PubMed Web of Science ®Google Scholar
• Wright, E., Jr., J. Scism‐Bacon, and L. Glass. 2006. Oxidative stress in type 2 diabetes: The role of fasting and postprandial glycaemia. International Journal of Clinical Practice 60 (3):308–14.
   PubMed Web of Science ®Google Scholar
• Wu, Y., D. Hui, N. A. M. Eskin, and S. W. Cui. 2016. Water-soluble yellow mustard mucilage: A novel ingredient with potent antioxidant properties. International Journal of Biological Macromolecules 91:710–5. doi: 10.1016/j.ijbiomac.2016.05.088.
   PubMed Web of Science ®Google Scholar
• Xu, B., C. Allard, A. I. Alvarez-Mercado, T. Fuselier, J. H. Kim, L. A. Coons, S. C. Hewitt, F. Urano, K. S. Korach, E. R. Levin, et al. 2018. Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes. Cell Reports 24 (1):181–96.
   PubMed Web of Science ®Google Scholar
• Xu, X., X. Jia, L. Mo, C. Liu, L. Zheng, Q. Yuan, and X. Zhou. 2017. Intestinal microbiota: A potential target for the treatment of postmenopausal osteoporosis. Bone Research 5:17046.
   PubMed Web of Science ®Google Scholar
• Xu, Y., N. Wang, H.-Y. Tan, S. Li, C. Zhang, and Y. Feng. 2020. Function of Akkermansia muciniphila in obesity: Interactions with lipid metabolism, immune response and gut systems. Frontiers in Microbiology 11:219. doi: 10.3389/fmicb.2020.00219.
   PubMed Web of Science ®Google Scholar
• Xu, Z., W. Chen, Q. Deng, Q. Huang, X. Wang, C. Yang, and F. Huang. 2020. Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice. Food & Function 11 (9):8077–88.
   PubMed Web of Science ®Google Scholar
• Yan, F., N. Li, J. Shi, H. Li, Y. Yue, W. Jiao, N. Wang, Y. Song, G. Huo, and B. Li. 2019. Lactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice. Food & Function 10 (9):5804–15.
   PubMed Web of Science ®Google Scholar
• Yan, J., S. Shi, H. Wang, R. Liu, N. Li, Y. Chen, and S. Wang. 2016. Neutral monosaccharide composition analysis of plant-derived oligo- and polysaccharides by high performance liquid chromatography. Carbohydrate Polymers 136:1273–80.
   PubMed Web of Science ®Google Scholar
• Yun, S. I., H. O. Park, and J. H. Kang. 2009. Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes. Journal of Applied Microbiology 107 (5):1681–6. doi: 10.1111/j.1365-2672.2009.04350.x.
   PubMed Web of Science ®Google Scholar
• Zaborska, K. E., and B. P. Cummings. 2018. Rethinking bile acid metabolism and signaling for type 2 diabetes treatment. Current Diabetes Reports 18 (11):109.
   PubMed Web of Science ®Google Scholar
• Zeng, Z., Q. Yuan, R. Yu, J. Zhang, H. Ma, and S. Chen. 2019. Ameliorative effects of probiotic Lactobacillus paracasei NL41 on insulin sensitivity, oxidative stress, and beta-cell function in a type 2 diabetes mellitus rat model. Molecular Nutrition & Food Research 63 (22):1900457. doi: 10.1002/mnfr.201900457.
   PubMed Web of Science ®Google Scholar
• Zhang, J., S. Wang, Z. Zeng, Y. Qin, Q. Shen, and P. Li. 2020. Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model. Journal of Functional Foods 67:103843. doi: 10.1016/j.jff.2020.103843.
   Web of Science ®Google Scholar
• Zhang, Z., Y. Chen, L. Xiang, Z. Wang, G. G. Xiao, and J. Hu. 2017. Effect of curcumin on the diversity of gut microbiota in ovariectomized rats. Nutrients 9 (10):1146. doi: 10.3390/nu9101146.
   PubMed Web of Science ®Google Scholar
• Zhao, D., H. Zhu, F. Gao, Z. Qian, W. Mao, Y. Yin, J. Tan, and D. Chen. 2020. Antidiabetic effects of selenium-enriched Bifidobacterium longum DD98 in type 2 diabetes model of mice. Food & Function 11 (7):6528–41.
   PubMed Web of Science ®Google Scholar
• Zhao, H., J. Chen, X. Li, Q. Sun, P. Qin, and Q. Wang. 2019. Compositional and functional features of the female premenopausal and postmenopausal gut microbiota. FEBS Letters 593 (18):2655–64.
   PubMed Web of Science ®Google Scholar
• Zhu, J., M. Liao, Z. Yao, W. Liang, Q. Li, J. Liu, H. Yang, Y. Ji, W. Wei, A. Tan, et al. 2018. Breast cancer in postmenopausal women is associated with an altered gut metagenome. Microbiome 6 (1):136.
   PubMedGoogle Scholar