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Research Article

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

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Pages 1-125 | Published online: 21 Oct 2008

REFERENCES

  • A.A. Abdel-Rahman, G.M. Blumenthal, S.A. Abou-Donia, F.A. Ali, A.E. Abdel-Monem, and M.B. Abou-Donia. (2002). Pharmacokinetic profile and placental transfer of a single intravenous injection of [(14)C]chlorpyrifos in pregnant rats.. Arch. Toxicol. 76:452–459.
  • A. Abdel-Rahman, A.M. Dechkovskaia, H. Mehta-Simmons, J.M. Sutton, X. Guan, W.A. Khan, and M.B. Abou-Donia. (2004). Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.. Arch. Toxicol. 78:467–476.
  • A. Abdel-Rahman, A. Dechkovskaia, H. Mehta-Simmons, X. Guan, W. Khan, and M. Abou-Donia. (2003). Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: Differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine.. J. Toxicol. Environ. Health A 66:2047–2066.
  • M.B. Abou-Donia, W.A. Khan, A.M. Dechkovskaia, L.B. Goldstein, S.L. Bullman, and A. Abdel-Rahman. (2006). In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.. Arch. Toxicol. 80:620–631.
  • A.W. Abu-Qare, A. Abdel-Rahman, C. Brownie, A.M. Kishk, and M.B. Abou-Donia. (2001). Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats.. J. Toxicol. Environ. Health A 63:173–189.
  • A.W. Abu-Qare, and M.B. Abou-Donia. (2001). Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon, alone and in combination, in pregnant rats.. J. Appl. Toxicol. 21:307–316.
  • J.F. Acquavella, B.H. Alexander, J.S. Mandel, C. Gustin, B. Baker, and P. Chapman. (2004). Glyphosate biomonitoring for farmers and their families: Results from the Farm Family Exposure Study.. Environ. Health Perspect. 12:321–326.
  • J.L. Adgate, D.B. Barr, C.A. Clayton, L.E. Eberly, N.C. Freeman, P.J. Lioy, L.L. Needham, E.D. Pellizzari, J.J. Quackenboss, A. Roy, and K. Sexton. (2001). Measurement of children's exposure to pesticides: Analysis of urinary metabolite levels in a probability-based sample.. Environ. Health Perspect. 109:583–590.
  • J.L. Adgate, A. Kukowski, C. Stroebel, P.J. Shubat, S. Morrell, J.J. Quackenboss, R.W. Whitmore, and K. Sexton. (2000). Pesticide storage and use patterns in Minnesota households with children.. J. Expos. Anal. Environ. Epidemiol. 10:159–167.
  • S. Adkins, K.N. Gan, M. Mody, and B.N. La Du. (1993). Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: Glutamine or arginine at position 191, for the respective A or B allozymes.. Am.J. Hum. Genet. 52:598–608.
  • L.A. Aiuto, S.G. Pavlakis, and R.A. Boxer. (1993). Life-threatening organophosphate-induced delayed polyneuropathy in a child after accidental chlorpyrifos ingestion.. J. Pediatr. 122:658–660.
  • N. Akhtar, M.K. Srivastava, and R.B. Raizada. (2006). Transplacental disposition and teratogenic effects of chlorpyrifos in rats.. J. Toxicol. Sci. 31:521–527.
  • M.C. Alavanja, M. Dosemeci, C. Samanic, J. Lubin, C.F. Lynch, C. Knott, J. Barker, J.A. Hoppin, D.P. Sandler, J. Coble, K. Thomas, and A. Blair. (2004). Pesticides and lung cancer risk in the agricultural health study cohort.. Am. J. Epidemiol. 160:876–885.
  • J.W. Albers, S. Berent, D.H. Garabrant, B. Giordani, S.J. Schweitzer, R.P. Garrison, and R.J. Richardson. (2004a). The effects of occupational exposure to chlorpyrifos on the neurologic examination of central nervous system function: A prospective cohort study.. J. Occup. Environ. Med. 46:367–378.
  • J.W. Albers, P. Cole, R.S. Greenberg, J.S. Mandel, R.R. Monson, J.H. Ross, W.R. Snodgrass, A. Spurgeon, and M. van Gemert. (1999). Analysis of chlorpyrifos exposure and human health: Expert panel report.. J. Toxicol. Environ. Health B 2:301–324.
  • J.W. Albers, D.H. Garabrant, J.L. Mattsson, C.J. Burns, S.S. Cohen, C. Sima, R.P. Garrison, R.J. Richardson, and S. Berent. (2007). Dose-effect analyses of occupational chlorpyrifos exposure and peripheral nerve electrophysiology.. Toxicol. Sci. 97:196–204.
  • J.W. Albers, D.H. Garabrant, S. Schweitzer, R.P. Garrison, R.J. Richardson, and S. Berent. (2004b). Absence of sensory neuropathy among workers with occupational exposure to chlorpyrifos.. Muscle Nerve 29:677–686.
  • J.E. Aldridge, E.D. Levin, F.J. Seidler, and T.A. Slotkin. (2005a). Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.. Environ. Health Perspect. 113:527–531.
  • J.E. Aldridge, E.D. Levin, F.J. Seidler, and T.A. Slotkin. (2005b). Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.. Environ. Health Perspect. 13:527–531.
  • J.E. Aldridge, A. Meyer, F.J. Seidler, and T.A. Slotkin. (2005c). Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure.. Environ. Health Perspect. 113:1027–1031.
  • J.E. Aldridge, F.J. Seidler, and T.A. Slotkin. (2003b). Changes in serotonin receptors in brain regions of rats after neonatal exposure to chlorpyrifos.. Toxicol. Sci. 72:124–125.
  • J.E. Aldridge, F.J. Seidler, and T.A. Slotkin. (2004). Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood.. Toxicologist 78:273.
  • J.E. Aldridge, F.J. Seidler, A. Meyer, I. Thillai, and T.A. Slotkin. (2003a). Serotonergic systems targeted by developmental exposure to chlorpyrifos: Effects during different critical periods.. Environ. Health Perspect. 111:1736–1743.
  • W.N. Aldridge. (1953). Serum esterases.I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.. Biochem. J. 53:110–117.
  • B.H. Alexander, C.J. Burns, M.J. Bartels, J.F. Acquavella, J.S. Mandel, C. Gustin, and B.A. Baker. (2006). Chlorpyrifos exposure in farm families: Results from the Farm Family Exposure Study.. J. Expos. Sci. Environ. Epidemiol. 16:447–456.
  • A. Alvarez-Arcaya, O. Combarros, J. Llorca, M. Sánchez-Guerra, J. Berciano, C. Fernández-Viadero, and N. Peña. (2000). The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women.. Acta Neurol. Scand 102:350–353.
  • S.M. Amer, and F.A. Aly. (1992). Cytogenetic effects of pesticides. IV. Cytogenetic effects of the insecticides Gardona and Dursban.. Mutat. Res. 279:165–170.
  • R.G. Ames, S.K. Brown, J. Rosenberg, R.J. Jackson, J.W. Stratton, and S.G. Quenon. (1989). Health symptoms and occupational exposure to flea control products among California pet handlers.. Am. Ind. Hyg. Assoc.J. 50:466–472.
  • H.A. Anderson, and M.S. Wolff. (2000). Environmental contaminants in human milk.. J. Expos. Anal. Environ. Epidemiol. 10:755–760.
  • B.J. Apelberg, F.R. Witter, J.B. Herbstman, A.M. Calafat, R.U. Halden, L.L. Needham, and L.R. Goldman. (2007). Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth.. Environ. Health Perspect. 115:1670–1676.
  • K.M. Ashry, A.W. Abu-Qare, F.R. Saleem, Y.A. Hussein, S.M. Hamza, A.M. Kishk, and M.B. Abou-Donia. (2002). Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats.. Arch. Toxicol. 76:30–39.
  • L.S. Aston, and J.N. Seiber. (1997). Fate of summertime airborne organophosphate pesticide residues in the Sierra Nevada mountains.. J. Environ. Qual. 26:1483–1492.
  • J.R. Atack, E.K. Perry, J.R. Bonhan, and R.H. Perry. (1987). Molecular forms of acetylcholinesterase and butyrylcholinesterase in human plasma and cerebrospinal fluid. J. Neurochem 48:1845–1850.
  • ATSDR. Toxicological profile for chlorpyrifos. Agency for Toxic Substances and Disease Registry, AtlantaGA, (1997).
  • T.T. Atterberry, W.T. Burnett, and J.E. Chambers. (1997). Age-related differences in parathion and chlorpyrifos toxicity in male rats: Target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism.. Toxicol. Appl. Pharmacol. 147:411–418.
  • K.B. Augustinsson, and M. Barr. (1963). Age variation in plasma arylesterase activity in children.. Clin. Chim. Acta 8:568–573.
  • J.C. Axelrad, C.V. Howard, and W.G. McLean. (2002). Interactions between pesticides and components of pesticide formulations in an in vitro neurotoxicity test.. Toxicology 173:259–268.
  • D. Bagchi, M. Bagchi, E.A. Hassoun, and S.J. Stohs. (1995). In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides.. Toxicology 104:129–140.
  • J. Bajgar, L. Bartosova, K. Kuca, D. Jun, and J. Fusek. (2007). Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.. Drug Chem. Toxicol 30:351–359.
  • B.A. Baker, B.H. Alexander, J.S. Mandel, J.F. Acquavella, and P. Chapman. (2004). Pesticide exposure in spouses from the Farm Family Exposure Study.. J. Toxicol. Clin. Toxicol. 42:802.
  • B.A. Baker, B.H. Alexander, J.S. Mandel, J.F. Acquavella, R. Honeycutt, and P. Chapman. (2005). Farm Family Exposure Study: Methods and recruitment practices for a biomonitoring study of pesticide exposure.. J. Expos. Anal. Environ. Epidemiol. 15:491–499.
  • J.E. Bakke, V.J. Feil, and C.E. Price. (1976). Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate.. J. Environ. Sci. Health Bull. 3:225–230.
  • J.E. Bakke, and C.E. Price. (1976). Metabolism of O,O-dimethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate in sheep and rats and of 3,5,6-trichloro-2-pyridinol in sheep.. J. Environ. Sci. Health B. 11:9–22.
  • J.M. Barnes. (1954). Organo-phosphorous insecticides. The toxic action of organophosphorous insecticides in mammals.. Chem. Ind. Jan 2.
  • D.B. Barr, and J. Angerer. (2006). Potential uses of biomonitoring data: A case study using the organophosphorus pesticides chlorpyrifos and malathion.. Environ. Health Perspect. 114:1763–1769.
  • D.B. Barr, J.R. Barr, V.L. Maggio, R.D. Whitehead, M.A. Sadowski, R.M. Whyatt, and L.L. Needham. (2002). A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry.. J. Chromatogr. B 778:99–111.
  • M.G. Barron, S.M. Plakas, and P.C. Wilga. (1991). Chlorpyrifos pharmacokinetics and metabolism following intravascular and dietary administration in channel catfish.. Toxicol. Appl. Pharmacol. 108:474–482.
  • G.M. Benke, and S.D. Murphy. (1975). The influence of age on the toxicity and metabolism of methyl parathion and parathion in male and female rats.. Toxicol. Appl. Pharmacol. 31:254–269.
  • G.S. Berkowitz, J.G. Wetmur, E. Birman-Deych, J. Obel, R.H. Lapinski, J.H. Godbold, I.R. Holzman, and M.S. Wolff. (2004). In utero pesticide exposure, maternal paraoxonase activity, and head circumference.. Environ. Health Perspect. 112:388–391.
  • G. Berkowitz, J. Wetmur, E. Birman-Deych, I. Holzman, and M. Wolff. (2003). Maternal exposure to indoor pesticides, paraoxonase activity, and fetal growth.. Am.J. Epidemiol. 157:S67.
  • P.E. Berteau, and W.A. Deen. (1978). A comparison of oral and inhalation toxicities of four insecticides to mice and rats.. Bull. Environ. Contam. Toxicol. 19:113–120.
  • A.M. Betancourt, and R. Carr. (2004). The effect of repeated oral ingestion of chlorpyrifos on cholinesterase and carboxylesterase activity in adult rats.. Toxicologist 78:276.
  • A.M. Betancourt, S.C. Burgess, and R.L. Carr. (2006). Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain.. Toxicol. Sci. 92:500–506.
  • W. Bicker, M. Lammerhofer, and W. Lindner. (2005b). Determination of chlorpyrifos metabolites in human urine by reversed-phase/weak anion exchange liquid chromatography-electrospray ionisation-tandem mass spectrometry.. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 822:160–169.
  • W. Bicker, M. Lammerhofer, D. Genser, H. Kiss, and W. Lindner. (2005a). A case study of acute human chlorpyrifos poisoning: Novel aspects on metabolism and toxicokinetics derived from liquid chromatography-tandem mass spectrometry analysis of urine samples.. Toxicol. Lett. 159:235–251.
  • J.A. Bomser, and J.E. Casida. (2001). Diethylphosphorylation of rat cardiac M2 muscarinic receptor by chlorpyrifos oxon in vitro.. Toxicol. Lett. 119:21–26.
  • J.A. Bomser, G.B. Quistad, and J.E. Casida. (2002). Chlorpyrifos oxon potentiates diacylglycerol-induced extracellular signal-regulated kinase (ERK 44/42) activation, possibly by diacylglycerol lipase inhibition.. Toxicol. Appl. Pharmacol. 178:29–36.
  • J. Bomser, and J.E. Casida. (2000). Activation of extracellular signal-regulated kinases (ERK 44/42) by chlorpyrifos oxon in Chinese hamster ovary cells.. J. Biochem. Mol. Toxicol. 14:346–353.
  • A. Bradman, D. Whitaker, L. Quiro'S, R. Castorina, B.C. Hebb, M. NIishoka, J. Morgan, D.B. Barr, M. Harnly, J.A. Brisben, L.S. Sheldon, T.E. Mckone, and B. Eskenazi. (2007). Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA.. J. Expos. Sci. Environ. Epidemiol. 17:331–349.
  • M.A. Bradman, M.E. Harnly, W. Draper, S. Seidel, S. Teran, D. Wakeham, and R. Neutra. (1997). Pesticide exposures to children from California's Central Valley: Results of a pilot study.. J. Expos. Anal. Environ. Epidemiol. 7:217–234.
  • F.E. Brenner, G.G. Bond, E.A. McLaren, S. Green, and R.R. Cook. (1989). Morbidity among employees engaged in the manufacture or formulation of chlorpyrifos.. Br. J. Ind. Med 46:133–137.
  • W.J. Breslin, A.B. Liberacki, D.A. Dittenber, and J.F. Quast. (1996). Evaluation of the developmental and reproductive toxicity of chlorpyrifos in the rat.. Fundam. Appl. Toxicol. 29:119–130.
  • V.H. Brophy, R.L. Jampsa, J.B. Clendenning, L.A. McKinstry, G.P. Jarvik, and C.E. Furlong. (2001). Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.. Am.J. Hum. Genet. 68:1428–1436.
  • V.H. Brophy, G.P. Jarvik, and C.E. Furlong. PON 1 polymorphisms.Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects L.G. Costa, and C.E. Furlong. Kluwer Academic Publishers, NorwellMA, (2002)53–77.
  • J.A. Buck, L.W. Brewer, M.J. Hooper, G.P. Cobb, and R.J. Kendall. (1996). Monitoring great horned owls for pesticide exposure in southcentral Iowa.. J. Wildl. Manage. 60:321–331.
  • R.J. Buck, H. Ozkaynak, J. Xue, V.G. Zartarian, and K. Hammerstrom. (2001). Modeled estimates of chlorpyrifos exposure and dose for the Minnesota and Arizona NHEXAS populations.. J. Expos. Anal. Environ. Epidemiol. 11:253–268.
  • R. Bullock, J. Touchon, H. Bergman, G. Gambina, Y. He, G. Rapatz, J. Nagel, and R. Lane. (2005). Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period.. Curr. Med. Res. Opin 21:1317–1327.
  • F.M. Buratti, and E. Testai. (2003). The inhibition of malathion detoxication by isomalathion and other OPTs in human liver microsomes.. Toxicol. Lett. 144:s152.
  • F.M. Buratti, C. Leoni, and E. Testai. (2006). Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides.. Toxicol. Lett. 167:245–255.
  • O. Burk, H. Tegude, I. Koch, E. Hustert, R. Wolbold, H. Glaeser, K. Klein, M.F. Fromm, A.K. Nuessler, P. Neuhaus, U.M. Zanger, M. Eichelbaum, and L. Wojnowski. (2002). Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.. J. Biol. Chem. 277:24280–24288.
  • C.J. Burns, J.B. Cartmill, B.S. Powers, and M.K. Lee. (1998). Update of the morbidity experience of employees potentially exposed to chlorpyrifos.. Occup. Environ. Med. 55:65–70.
  • P.J. Bushnell, C.N. Pope, and S. Padilla. (1993). Behavioral and neurochemical effects of acute chlorpyrifos in rats: Tolerance to prolonged inhibition of cholinesterase. J. Pharmacol. Exp. Ther 266:1007–1017.
  • P.J. Bushnell, K.L. Kelly, and TR. Ward. (1994). Repeated inhibition of cholinesterase by chlorpyrifos in rats: Neurochemical, pharmacological, and behavioral indices of tolerance. J. Pharmacol. Exp. Therap 270:15–25.
  • W. Butte, and B. Heinzow. (2002). Pollutants in house dust as indicators of indoor contamination.. Rev. Environ. Contam. Toxicol. 175:1–46.
  • S.L. Byrne, B.A. Shurdut, and D.G. Saunders. (1998). Potential chlorpyrifos exposure to residents following standard crack and crevice treatment.. Environ. Health Perspect. 106:725–731.
  • S. Callaway, D.R. Davies, and J.P. Rutland. (1951). Blood cholinesterase levels and range of personal variation in a healthy adult population.. Br. Med. J. 2:812–816.
  • C.G. Campbell, F.J. Seidler, and T.A. Slotkin. (1997). Chlorpyrifos interferes with cell development in rat brain regions.. Brain Res. Bull. 43:179–189.
  • E.J. Carlton, H.L. Moats, M. Feinberg, P. Shepard, R. Garfinkel, R. Whyatt, and D. Evans. (2004). Pesticide sales in low-income, minority neighborhoods.. J. Commun. Health 29:231–244.
  • R.L. Carr, H.W. Chambers, J.A. Guarisco, J.R. Richardson, J. Tang, and J.E. Chambers. (2001). Effects of repeated oral postnatal exposure to chlorpyrifos on open-field behavior in juvenile rats.. Toxicol. Sci. 59:260–267.
  • J.E. Casida, and G.B. Quistad. (2004). Organophosphate toxicology: Safety aspects of nonacetylcholinesterase secondary targets.. Chem. Res. Toxicol. 17:983–998.
  • J.E. Casida, and G.B. Quistad. (2005). Serine hydrolase targets of organophosphorus toxicants.. Chem. Biol. Interact. 157–158:277–283.
  • R. Castorina, A. Bradman, T.E. McKone, D.B. Barr, M.E. Harnly, and B. Eskenazi. (2003). Cumulative organophosphate pesticide exposure and risk assessment among pregnant women living in an agricultural community: A case study from the CHAMACOS cohort.. Environ. Health Perspect. 111:1640–1648.
  • A. Caughlan, K. Newhouse, U. Namgung, and Z. Xia. (2004). Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases.. Toxicol. Sci. 78:125–134.
  • J.B. Cavanagh. (1963). Organo-phosphorus neurotoxicity: A model “dying back” process comparable to certain human neurological disorders.. Guys Hosp. Rep. 112:303–319.
  • T.K. Chakraborti, J.D. Farrar, and C.N. Pope. (1993). Comparative neurochemical and neurobehavioral effects of repeated chlorpyrifos exposures in young and adult rats.. Pharmacol. Biochem. Behav. 46:219–224.
  • H.W. Chambers. Organophosphorus compounds; An overview, Organophosphates: Chemistry, Fate and Effects J. Chambers, and P. Levi. Academic Press, New York, (1992)11–12.
  • J.E. Chambers, and H.W. Chambers. (1989). Oxidative desulfuration of chlorpyrifos, chlorpyrifos-methyl, and leptophos by rat brain and liver.. J. Biochem. Toxicol. 4:201–203.
  • S.M. Chanda, P. Harp, J. Liu, and C.N. Pope. (1995). Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats.. J. Toxicol. Environ. Health 44:189–202.
  • S.M. Chanda, S.R. Mortensen, V.C. Moser, and S. Padilla. (1997). Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: An in vitro and in vivo comparison.. Fundam. Appl. Toxicol. 38:148–157.
  • A. Chatonnet, and O. Lockridge. (1989). Comparison of butyrylcholinesterase and acetylcholinesterase.. Biochem. J. 260:625–634.
  • J. Chaudhuri, T.K. Chakraborti, S. Chanda, and C.N. Pope. (1993). Differential modulation of organophosphate-sensitive muscarinic receptors in rat brain by parathion and chlorpyrifos.. J. Biochem. Toxicol. 8:207–216.
  • J. Chen, M. Kumar, W. Chan, G. Berkowitz, and J.G. Wetmur. (2003a). Increased influence of genetic variation on PON1 activity in neonates.. Environ. Health Perspect. 111:1403–1409.
  • Q. Chen, S.E. Reis, C.M. Kammerer, D.M. McNamara, R. Holubkov, B.L. Sharaf, G. Sopko, D.F. Pauly, C.N. Merz, and M.I. Kamboh. (2003b). Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study.. Am. J. Hum. Genet. 72:13–22.
  • W.L. Chen, J.J. Sheets, R.J. Nolan, and J.L. Mattsson. (1999). Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose.. Regul. Toxicol. Pharmacol. 29:15–22.
  • N. Cherry, M. Mackness, P. Durrington, A. Povey, M. Dippnall, T. Smith, and B. Mackness. (2002). Paraoxonase (PON1) polymorphisms in farmers attributing ill health to sheep dip.. Lancet 359:763–764.
  • K.P. Chiang, S. Niessen, A. Saghatelian, and B.F. Cravatt. (2006). An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem. Biol 13:1041–1050.
  • S. Chiappa, S. Padilla, C. Koenigsberger, V. Moser, and S. Brimijoin. (1995). Slow accumulation of acetylcholinesterase in rat brain during enzyme inhibition by repeated dosing with chlorpyrifos.. Biochem. Pharmacol. 49:955–963.
  • K. Choi, H. Joo, R.L. Rose, and E. Hodgson. (2006). Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes.. J. Biochem. Mol. Toxicol. 20:279–291.
  • F.S. Cieszlak. Chlorpyrifos oxon: Acute oral toxicity in Fischer 344 rats, DECO HET K-045925-004 (C006) GLP. , , (1999) Unpublished..
  • C.A. Clayton, E.D. Pellizzari, R.W. Whitmore, J.J. Quackenboss, J. Adgate, and K. Sefton. (2003). Distributions, associations, and partial aggregate exposure of pesticides and polynuclear aromatic hydrocarbons in the Minnesota Children's Pesticide Exposure Study (MNCPES).. J. Expos. Anal. Environ. Epidemiol. 13:100–111.
  • D.J. Clegg, and M. Van Gemert. (1999). Determination of the reference dose for chlorpyrifos: Proceedings of an expert panel.. J. Toxicol. Environ. Health B 2:211–255.
  • R.C. Cochran. (2002). Appraisal of risks from nonoccupational exposure to chlorpyrifos.. Regul. Toxicol. Pharmacol. 35:105–121.
  • J. Cohn, and R.C. MacPhail. (1997). Chlorpyrifos produces selective learning deficits in rats working under a schedule of repeated acquisition and performance.. J. Pharmacol. Exp. Ther 283:312–320.
  • T.B. Cole, R.L. Jampsa, B.J. Walter, T.L. Arndt, R.J. Richter, D.M. Shih, A. Tward, A.J. Lusis, R.M. Jack, L.G. Costa, and C.E. Furlong. (2003a). Expression of human paraoxonase (PON1) during development.. Pharmacogenetics 13:357–364.
  • T.B. Cole, C. Pettan-Brewer, T.M. BurbAChEr, L.G. Costa, and C.E. Furlong. (2003b). Paraoxonase (PON1) polymorphisms and their significance for the developmental toxicity of organophosphates.. Neurotoxicol. Teratol. 25:390.
  • T.B. Cole, B.J. Walter, L.G. Costa, R.J. Richter, C. Pettan-Brewer, D.M. Shih, A. Tward, A.J. Lusis, and C.E. Furlong. (2003c). Contribution of paraoxonase (PON1) levels and Q192R genotype to organophosphate detoxication: Evidence from humans and “humanized” transgenic mice.. Toxicol. Sci. 72:100.
  • T.B. Cole, B.J. Walter, D.M. Shih, A.D. Tward, A.J. Lusis, C. Timchalk, R.J. Richter, L.G. Costa, and C.E. Furlong. (2005). Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism.. Pharmacogenet. Genom. 15:589–598.
  • M.F. Cometa, F.M. Buratti, S. Fortuna, P. Lorenzini, M.T. Volpe, L. Parisi, E. Testai, and A. Meneguz. (2007). Cholinesterase inhibition and alterations of hepatic metabolism by oral acute and repeated chlorpyrifos administration to mice.. Toxicology 234:90–102.
  • T.J. Cook, and S.S. Shenoy. (2003). Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat.. Toxicology 184:125–133.
  • R.A. Corley, L.L. Calhoun, D.A. Dittenber, L.G. Lomax, and T.D. Landry. (1989). Chlorpyrifos: A 13-week nose-only vapor inhalation study in Fischer 344 rats.. Fundam. Appl. Toxicol. 13:616–618.
  • L.G. Costa, B.E. McDonald, S.D. Murphy, G.S. Omenn, R.J. Richter, A.G. Motulsky, and C.E. Furlong. (1990). Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats.. Toxicol. Appl. Pharmacol. 103:66–76.
  • L.G. Costa, R.J. Richter, W.F. Li, T. Cole, M. Guizzetti, and C.E. Furlong. (2003). Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity.. Biomarkers 8:1–12.
  • L.G. Costa, A. Vitalone, T.B. Cole, and C.E. Furlong. (2005). Modulation of paraoxonase (PON1) activity.. Biochem. Pharmacol. 69:541–550.
  • F. Coulston, L. Golberg, and T. Griffinn. Safety evaluation of Dowco 179 in human volunteers. , , (1972) Unpublished report from the Institute of Experimental Pathology and Toxicology, Albany Medical College..
  • F. Coulston, L. Goldberg, R. Abraham, K.F. Benitz, T.B. Griffin, and M. Norvell. Final report on safety evalulation and metabolic studies on Dowco 179.. Albany Medical College, AlbanyN.Y., (1971).
  • J. Cowan, C.M. Sinton, A.W. Varley, F.H. Wians, R.W. Haley, and R.S. Munford. (2001). Gene therapy to prevent organophosphate intoxication.. Toxicol. Appl. Pharmacol. 173:1–6.
  • J.A. Crow, A. Borazjani, P.M. Potter, and M.K. Ross. (2007). Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal, liver and serum carboxylesterases.. Toxicol. Appl. Pharmacol. 221:1–12.
  • T.L. Crumpton, F.J. Seidler, and T.A. Slotkin. (2000a). Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: Effects on nuclear transcription factors involved in cell replication and differentiation.. Brain Res. 857:87–98.
  • T.L. Crumpton, F.J. Seidler, and T.A. Slotkin. (2000b). Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?. Brain Res. Dev. Brain Res. 121:189–195.
  • Y. Cui, J. Guo, B. Xu, and Z. Chen. (2006). Potential of chlorpyrifos and cypermethrin forming DNA adducts.. Mutat. Res. 604:36–41.
  • B.D. Curwin, M.J. Hein, W.T. Sanderson, D.B. Barr, D. Heederik, S.J. Reynolds, E.M. Ward, and M.C. Alavanja. (2005a). Urinary and hand wipe pesticide levels among farmers and nonfarmers in Iowa.. J. Expos. Anal. Environ. Epidemiol. 15:500–508.
  • B.D. Curwin, M.J. Hein, W.T. Sanderson, M.G. Nishioka, S.J. Reynolds, E.M. Ward, and M.C. Alavanja. (2005b). Pesticide contamination inside farm and nonfarm homes.. J. Occup. Environ. Hyg. 2:357–367.
  • B.D. Curwin, M.J. Hein, W.T. Sanderson, C. Striley, D. Heederik, H. Kromhout, S.J. Reynolds, and M.C. Alavanja. (2007a). Pesticide dose estimates for children of Iowa farmers and non-farmers.. Environ. Res. 105:307–315.
  • B.D. Curwin, M.J. Hein, W.T. Sanderson, C. Striley, D. Heederik, H. Kromhout, S.J. Reynolds, and M.C. Alavanja. (2007b). Urinary pesticide concentrations among children, mothers and fathers living in farm and non-farm households in Iowa.. Ann. Occup. Hyg. 51:53–65.
  • B. Curwin, W. Sanderson, S. Reynolds, M. Hein, and M. Alavanja. (2002). Pesticide use and practices in an Iowa farm family pesticide exposure study.. J. Agric. Safety Health 8:423–433.
  • M. Cygler, J.D. Schrag, J.L. Sussman, M. Harel, I. Silman, M.K. Gentry, and B.P. Doctor. (1993). Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.. Protein Sci. 2:366–382.
  • D. Dai, J. Tang, R.L. Rose, E. Hodgson, R.J. Bienstock, H.W. Mohrenwasser, and J.A. Goldstein. (2001). Identification of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.. J. Pharmacol. Exp. Ther. 299:825–831.
  • K. Dam, S.J. Garcia, F.J. Seidler, and T.A. Slotkin. (1999). Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways.. Brain Res. Dev. Brain Res. 116:9–20.
  • K. Dam, F.J. Seidler, and T.A. Slotkin. (1998). Developmental neurotoxicity of chlorpyrifos: Delayed targeting of DNA synthesis after repeated administration.. Brain Res. Dev. Brain Res. 108:39–45.
  • K. Dam, F.J. Seidler, and T.A. Slotkin. (2000). Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity.. Brain Res. Dev. Brain Res. 121:179–187.
  • K. Dam, F.J. Seidler, and T.A. Slotkin. (2003). Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics.. Brain Res. Bull. 59:261–265.
  • S. Darvesh, D.A. Hopkins, and C. Geula. (2003). Neurobiology of butyrylcholinesterase.. Nat. Rev. Neurosci 4:131–138.
  • K.P. Das, and S. BaroneJr.. (1999). Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: Is acetylcholinesterase inhibition the site of action?. Toxicol. Appl. Pharmacol. 160:217–230.
  • H.G. Davies, R.J. Richter, M. Keifer, C.A. Broomfield, J. Sowalla, and C.E. Furlong. (1996). The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin.. Nature Genet. 14:334–336.
  • M.M. Deacon, J.S. Murray, M.K. Pilny, K.S. Rao, D.A. Dittenber, J.R. Hanley, and J.A. John. (1980). Embryotoxicity and fetotoxicity of orally administered chlorpyrifos in mice.. Toxicol. Appl. Pharmacol. 54:31–40.
  • W. Dekant. (2001). Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation.. Toxicol. Lett. 124:21–36.
  • F. DeMatteis. (1974). Covalent binding of sulphur to microsomes and loss of cytochrome P450 during oxidative desulphuration of several chemicals.. Mol. Pharmacol 10:849–854.
  • H.J. de Silva, P.S. Sanmuganathan, and N. Senanayake. (1994). Isolated bilateral recurrent laryngeal nerve paralysis: A delayed complication of organophosphorous poisoning.. Hum. Exp. Toxicol 13:171–173.
  • R.B. Dick, K. Steenland, E.F. Krieg, and C.J. Hines. (2001). Evaluation of acute sensory-motor effects and test sensitivity using termiticide workers exposed to chlorpyrifos.. Neurotoxicol. Teratol. 23:381–393.
  • Dow. Acute inhalation toxicity study in rats exposed to pyrenone Dursban aqueous base. Cosmopolitan Safety Evaluation, Inc., LafayetteNJ, (1983a).
  • Dow. Dursban insecticide: Assessment of neonatal survival in a two generation reproduction study in rats. Dow Chemical USA, Lake Jackson Research Center, FreeportTX, (1983b).
  • Dow. Acute inhalation study in rats exposed to non-volatile portion of pyrenone-Dursban W.B. pressurized spray. Cosmopolitan Safety Evaluation, Inc., LafayetteNJ, (1984).
  • Dow. Cholrpyrifos: 13-week neurotoxicity study in Fisher 344 rats. Dow Chemical Co., Health and Environmental Sciences, MidlandMI, (1993).
  • Dow. Toxicology studies on metabolites; Chapter 5.8.1, Toxicological and metabolism studies on the active substance. Dow Agrosciences, MidlandMI, (2002).
  • M.D. DulaneyJr., B. Hoskins, and I.K. Ho. (1985). Studies on low dose subacute administration of soman, sarin and tabun in the rat.. Acta Pharmacol. Toxicol. (Copenh.) 57:234–241.
  • P. Duramad, I.B. Tager, J. Leikauf, B. Eskenazi, and N.T. Holland. (2006). Expression of Th1/Th2 cytokines in human blood after in vitro treatment with chlorpyrifos, and its metabolites, in combination with endotoxin LPS and allergen Der p1.. J. Appl. Toxicol. 26:458–465.
  • F. Dutheil, P. Beaune, and M.A. Loriot. (2008). Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain. Biochimie 90: 42636. Epub 2007 Oct 22.
  • E.G. Duysen, B. Li, S. Darvesh, and O. Lockridge. (2007). Sensitivity of butyrylcholinesterase knockout mice to (–)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.. Toxicology 233:60–69.
  • J.A. Dybowski, S.R. Mortensen, and J.L. Mattsson. (2001). Comparison of chlorpyrifos (CPF) concentrations for in vitro and in vivo effects.. Toxicologist 60:325. (abstr. 1546)
  • S.M. Dyer, M. Cattani, D.L. Pisaniello, F.M. Williams, and J.W. Edwards. (2001). Peripheral cholinesterase inhibition by occupational chlorpyrifos exposure in Australian termiticide applicators.. Toxicology 169:177–185.
  • D.L. Eaton. (2000). Biotransformation enzyme polymorphism and pesticide susceptibility.. Neurotoxicology 21:101–111.
  • D.J. Ecobichon, and D.S. Stephens. (1973). Perinatal development of human blood esterases.. Clin. Pharmacol. Ther. 14:41–47.
  • P.P. Egeghy, J.J. Quackenboss, S. Catlin, and P.B. Ryan. (2005). Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers.. J. Expos. Anal. Environ. Epidemiol. 15:388–397.
  • A.H. El-Sebae, N.S. Ahmed, and S.A. Soliman. (1978). Effect of pre-exposure on acute toxicity of organophosphorus insecticides to white mice.. J. Environ. Sci. Health B 13:11–24.
  • S.M. Engel, G.S. Berkowitz, D.B. Barr, S.L. Teitelbaum, J. Siskind, S.J. Meisel, J.G. Wetmur, and M.S. Wolff. (2007). Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort.. Am.J. Epidemiol. 165:1397–1404.
  • L.J. England, J.S. Kendrick, P.M. Gargiullo, S.C. Zahniser, and W.H. Hannon. (2001). Measures of maternal tobacco exposure and infant birth weight at term.. Am.J. Epidemiol. 153:954–960.
  • EPA. Report on FQPA Tolerance Reassessment Progress and Risk Management Decision for Chlorpyrifos Methyl. U.S. EPA, WashingtonDC, (2001).
  • EPA. Interim Reregistration Eligibility Decision for Chlorpyrifos. U.S. EPA, WashingtonDC, (2002).
  • B. Eskenazi, A. Bradman, and R. Castorina. (1999). Exposures of children to organophosphate pesticides and their potential adverse health effects.. Environ. Health Perspect. 107 (Suppl 3):409–419.
  • B. Eskenazi, K. Harley, A. Bradman, E. Weltzien, N.P. Jewell, D.B. Barr, C.E. Furlong, and N.T. Holland. (2004). Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population.. Environ. Health Perspect. 112:1116–1124.
  • B. Eskenazi, A.R. Marks, A. Bradman, K. Harley, D.B. Barr, C. Johnson, N. Morga, and N.P. Jewell. (2007). Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.. Environ. Health Perspect. 115:792–798.
  • B. Eskenazi, A.W. Prehn, and R.E. Christianson. (1995). Passive and active maternal smoking as measured by serum cotinine: The effect on birthweight.. Am. J. Public Health 85:395–398.
  • R.W. Everett. (1982). Effect of Dursban 44 on semen output of Holstein bulls.. J. Dairy Sci. 65:1781–1794.
  • U. Fagerholm, M. Johansson, and H. Lennernas. (1996). Comparison between permeability coefficients in rat and human jejunum.. Pharm. Res. 13:1336–1342.
  • A.T. Farag, A.M. El Okazy, and A.F. El-Aswed. (2003). Developmental toxicity study of chlorpyrifos in rats.. Reprod. Toxicol. 17:203–208.
  • FDA. Food and Drug Administration Pesticide Program Residue Monitoring 2003. U.S. Food and Drug Administration, WashingtonDC, (2005).
  • R.A. Fenske, K.G. Black, K.P. Elkner, C.L. Lee, M.M. Methner, and R. Soto. (1990). Potential exposure and health risks of infants following indoor residential pesticide applications.. Am J. Public Health 80:689–693.
  • R.A. Fenske, G. Kedan, C. Lu, J.A. Fisker-Andersen, and C.L. Curl. (2002a). Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State.. J. Expos. Anal. Environ. Epidemiol. 12:21–28.
  • R.A. Fenske, C. Lu, D. Barr, and L. Needham. (2002b). Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State.. Environ. Health Perspect. 110:549–553.
  • N.C.G. Freeman, M. Jimenez, K.J. Reed, S. Gurunathan, R.D. Edwards, A. Roy, J.L. Adgate, E.D. Pellizzari, J. Quackenboss, K. Sexton, and P.J. Lioy. (2001). Quantitative analysis of children's microactivity patterns: The Minnesota Children's Pesticide Exposure Study. J. Expos. Anal. Environ. Epidemiol. 11:501–509.
  • K. Fujioka, and J.E. Casida. (2007). Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.. Chem. Res. Toxicol. 20:1211–1217.
  • C.E. Furlong. (2007). Genetic variability in the cytochrome P450-paraoxonase (PON1) pathways for the detoxication of organophosphorus compounds.. J. Biochem. Mol. Toxicol. 21:197–205.
  • C.E. Furlong, N. Holland, R.J. Richter, A. Bradman, A. Ho, and B. Eskenazi. (2006). PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity.. Pharmacogenet. Genom. 16:183–190.
  • C.E. Furlong, R.J. Richter, S.L. Seidel, and A.G. Motulsky. (1988). Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon.. Am. J. Hum. Genet. 43:230–238.
  • T.B. Gaines. (1969). Acute toxicity of pesticides.. Toxicol. Appl. Pharmacol 14 (3):515–534.
  • M.A. Gallo, and N.J. Lawryk. Organic phosphorous pesticides, Handook of Pesticide Toxicology, Vol 2, Classes of PesticidesW.J. Hayes, and E.R. LawsJr.. Academic Press, New York, (1991)917–1123.
  • K.N. Gan, A. Smolen, H.W. Eckerson, and B.N. La Du. (1991). Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities.. Drug Metab. Dispos. 19:100–106.
  • S.J. Garcia, F.J. Seidler, and T.A. Slotkin. (2003). Developmental neurotoxicity elicited by prenatal or postnatal chlorpyrifos exposure: Effects on neurospecific proteins indicate changing vulnerabilities.. Environ. Health Perspect. 111:297–303.
  • S.J. Garcia, F.J. Seidler, T.L. Crumpton, and T.A. Slotkin. (2001). Does chlorpyrifos target glial cell development?. Neurotoxicology (Little Rock) 22:526.
  • S.J. Garcia, F.J. Seidler, D. Qiao, and T.A. Slotkin. (2002). Chlorpyrifos targets developing glia: Effects on glial fibrillary acidic protein.. Brain Res. Dev. Brain Res. 133:151–161.
  • N.E. Garrett, H.F. Stack, M.A. Jackson, and M.D. Waters. Genotoxic and Carcinogenic Potential of Anticholinesterases, Clinical and Experimental Toxicology of Organophosphates and CarbamatesB. Ballantyne, and T.C. Marrs. , , (1992).
  • D.A. Gearhart, D.W. Sickles, J.J. Buccafusco, M.A. Prendergast, and A.V. TerryJr.. (2007). Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility.. Toxicol. Appl. Pharmacol. 218:20–29.
  • L.A. Geer, N. Cardello, M.J. Dellarco, T.J. Leighton, R.P. Zendzian, J.D. Roberts, and T.J. Buckley. (2004). Comparative analysis of passive dosimetry and biomonitoring for assessing chlorpyrifos exposure in pesticide workers.. Ann. Occup. Hyg. 48:683–695.
  • C. Geula, and N. Nagykery. (2007). Butyrylcholinesterase activity in the rat forebrain and upper brainstem: Postnatal development and adult distribution.. Exp. Neurol. 204:640–657.
  • E. Giacobini, R. Spiegel, A. Enz, A.E. Veroff, and N.R. Cutler. (2002). Inhibition of acety-and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: Correlation with cognitive benefit.. J. Neural Trans. 109:1053–65.
  • E. Giacobini. (2001). Selective inhibitors of butyrylcholinesterase: A valid alternative for therapy of Alzheimer's disease?. Drugs Aging 18:891–898.
  • J.E. Gibson, R.K. Peterson, and B.A. Shurdut. (1998). Human exposure and risk from indoor use of chlorpyrifos.. Environ. Health Perspect. 106:303–306.
  • J.E. Gibson. (1999). Chlorpyrifos (Dursban) and Dow employees: Response.. Environ. Health Perspect. 107:A134.
  • G. Giordano, Z. Afsharinejad, M. Guizzetti, A. Vitalone, T.J. Kavanagh, and L.G. Costa. (2007). Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency.. Toxicol. Appl. Pharmacol. 219:181–189.
  • B.B. Gollapudi, A.L. Mendrala, and V.A. Linscombe. (1995). Evaluation of the genetic toxicity of the organophosphate insecticide chlorpyrifos.. Mutat. Res. 342:25–36.
  • S.M. Gordon, P.J. Callahan, M.G. Nishioka, M.C. Brinkman, M.K. O'Rourke, M.D. Lebowitz, and D.J. Moschandreas. (1999). Residential environmental measurements in the national human exposure assessment survey (NHEXAS) pilot study in Arizona: Preliminary results for pesticides and VOCs.. J. Expos. Anal. Environ. Epidemiol. 9:456–470.
  • P. Grandjean, R. Harari, D.B. Barr, and F. Debes. (2006). Pesticide exposure and stunting as independent predictors of neurobehavioral deficits in Ecuadorian school children.. Pediatrics 117:e546–556.
  • P. Griffin, H. Mason, K. Heywood, and J. Cocker. (1999). Oral and dermal absorption of chlorpyrifos: A human volunteer study.. J. Occup. Environ. Med. 56:10–13.
  • P. Griffin, M. Payne, H. Mason, E. Freedlander, A.D. Curran, and J. Cocker. (2000). The in vitro percutaneous penetration of chlorpyrifos.. Hum. Exp. Toxicol. 19:104–107.
  • M. Guizzetti, S. Pathak, G. Giordano, and L.G. Costa. (2005). Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation.. Toxicology 215:182–190.
  • F. Gultekin, I. Karakoyun, R. Sutcu, E. Savik, G. Cesur, H. Orhan, and N. Delibas. (2007). Chlorpyrifos increases the levels of hippocampal NMDA receptor subunits NR2A and NR2B in juvenile and adult rats.. Int. J. Neurosci. 117:47–62.
  • F. Gultekin, M. Ozturk, and M. Akdogan. (2000). The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro).. Arch. Toxicol. 74:533–538.
  • E.L. Gunderson. (1995a). Dietary intake of pesticides, selected elements, and other chemicals: FDA total diet study, June 1984–April 1986.. J. AOAC International 78:910–921.
  • E.L. Gunderson. (1995b). FDA total diet study, July 1986-April 1991, dietary intakes of pesticides, selected elements, and other chemicals.. J. AOAC Int. 78:1353–1363.
  • S.X. Guo-Ross, J.E. Chambers, E.C. Meek, and R.L. Carr. (2007). Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion.. Toxicol. Sci. 100:118–127.
  • S. Gurunathan, M. Robson, N. Freeman, B. Buckley, A. Roy, R. Meyer, J. Bukowski, and P.J. Lioy. (1998). Accumulation of chlorpyrifos on residential surfaces and toys accessible to children.. Environ. Health Perspect. 106:9–16.
  • P.J. Haas, W.B. Buck, J.E. Hixon, R.D. Shanks, W.C. Wagner, P.G. Weston, and H.L. Whitmore. (1983). Effect of chlorpyrifos on Holstein steers and testosterone-treated Holstein bulls.. Am. J. Vet. Res. 44:879–881.
  • J.E. Haddow, G.J. Knight, G.E. Palomaki, and P.K. Haddow. (1988). Estimating fetal morbidity and mortality resulting from cigarette smoke exposure by measuring cotinine levels in maternal serum.. Prog. Clin. Biol. Res. 281:289–300.
  • R.W. Haley, S. Billecke, and B.N. La Du. (1999). Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans.. Toxicol. Appl. Pharmacol. 157:227–233.
  • J. Halpert, D. Hammond, and R.A. Neal. (1980). Inactivation of purified rat liver cytochrome P-450 during the metabolism of parathion (diethyl p-nitrophenyl phosphorothionate).. J. Biol. Chem. 255:1080–1089.
  • T.R. HanleyJr., E.W. Carney, and E.M. Johnson. (1998). 3,5,6-Trichloro-2-pyridinol: Developmental toxicity studies in rats and rabbits.. Toxicologist 42:255.
  • T.R. HanleyJr., E.W. Carney, and E.M. Johnson. (2000). Developmental toxicity studies in rats and rabbits with 3,5,6-trichloro-2-pyridinol, the major metabolite of chlorpyrifos.. Toxicol. Sci. 53:100–108.
  • R.D. Harbison. (1975). Prenatal development of human blood esterases.. Clin. Pharmacol. Ther. 14:41–47.
  • M. Harnly, R. McLaughlin, A. Bradman, M. Anderson, and R. Gunier. (2005). Correlating agricultural use of organophosphates with outdoor air concentrations: A particular concern for children.. Environ. Health Perspect. 113:1184–1189.
  • M. Harnly, R. McLaughlin, R. Gunier, A. Bradman, and M. Anderson. (2006). Organophosphates and outdoor air: Harnly et al. respond [4].. Environ. Health Perspect. 114:A339–A340.
  • S.L. Hartgraves, and M.R. Murphy. Behavioral effects of low-dose nerve agents, Chemical Warfare AgentsS.M. Somani. Academic Press, San Diego, (1992)125.
  • Y. Hashim, D. Shepherd, S. Wiltshire, R.R. Holman, J.C. Levy, A. Clark, and C.A. Cull. (2001). Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects.. Diabetologia 44:2227–2230. Erratum in: Diabetologia 2002;45(3):459
  • C. Hassett, R.J. Richter, R. Humbert, C. Chapline, J.W. Crabb, C.J. Omiecinski, and C.E. Furlong. (1991). Characterization of cDNA clones encoding rabbit and human serum paraoxonase: The mature protein retains its signal sequence.. Biochemistry 30:10141–10149.
  • M. Hayes. Pesticides Studies in Man. Williams & Wilkins, BaltimoreMD, (1982).
  • E Hedlund, J.A. Gustafsson, and M. Warner. (2001). Cytochrome P450 in the brain; A review.. Curr. Drug Metab 2:245–263.
  • R.H.J. Hill, S.L. Head, S. Baker, M. Gregg, D.B. Shealy, S.L. Bailey, C.C. Williams, E.J. Sampson, and L.L. Needham. (1995). Pesticide residues in urine of adults living in the United States: Reference range concentrations.. Environ. Res. 71:99–108.
  • P.C. Hirom, P. Millburn, R.L. Smith, and R.T. Williams. (1972). Species variations in the threshold molecular-weight factor for the biliary excretion of organic anions.. Biochem. J. 129:1071–1077.
  • M.J. Hodgson, G.D. Block, and D.K. Parkinson. (1986). Organophosphate poisoning in office workers.. J. Occup. Med. 28:434–437.
  • N. Holland, C. Furlong, M. Bastaki, R. Richter, A. Bradman, K. Huen, K. Beckman, and B. Eskenazi. (2006). Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns.. Environ. Health Perspect. 114:985–991.
  • C. Holmes, C. Ballard, D. Lehmann, A. David Smith, H. Beaumont, I.N. Day, M. Nadeem Khan, S. Lovestone, M. McCulley, C.M. Morris, D.G. Munoz, K. O'Brien, C. Russ, T. Del Ser, and D. Warden. (2005). Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation.. J. Neurol. Neurosurg Psychiatry 76:640–643.
  • B. Holmstedt. (1959). Pharmacology of organophosphorus cholinesterase inhibitors.. Pharmacol. Rev. 11:567–688.
  • S.B. Hooser, V.R. Beasley, J.P. Sundberg, and K. Harlin. (1988). Toxicologic evaluation of chlorpyrifos in cats.. Am. J. Vet. Res. 49:1371–1375.
  • P. Hore, M. Robson, N. Freeman, J. Zhang, D. Wartenberg, H. Ozkaynak, N. Tulve, L. Sheldon, L. Needham, D. Barr, and P.J. Lioy. (2005). Chlorpyrifos accumulation patterns for child-accessible surfaces and objects and urinary metabolite excretion by children for 2 weeks after crack-and-crevice application.. Environ. Health Perspect. 113:211–219.
  • P. Hore, V. Zartarian, J. Xue, H. Ozkaynak, S.-W. Wang, Y.-C. Yang, P.-L. Chu, L. Sheldon, M. Robson, L. Needham, D. Barr, N. Freeman, P. Georgopoulos, and P.J. Lioy. (2006). Children's residential exposure to chlorpyrifos: Application of CPPAES field measurements of chlorpyrifos and TCPy within MENTOR/SHEDS-pesticides model.. Sci. Total Environ. 366:525–537.
  • B. Hoskins, and I.K. Ho. Tolerance of organophosphate inhibitors, Organophosphates: Chemistry, Fate and EffectsJ.E. Chambers, and P.E. Lei. Academic Press, New York, (1992)285.
  • T.-C. Hour, L. Chen, and J.-K. Lin. (1998). Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests.. Mutagenesis 13:157166.
  • A.S. Howard, R. Bucelli, D.A. Jett, D. Bruun, D. Yang, and P.J. Lein. (2005). Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures.. Toxicol. Appl. Pharmacol. 207:112–124.
  • M.D. Howard, and C.N. Pope. (2002). In vitro effects of chlorpyrifos, parathion, methyl parathion and their oxons on cardiac muscarinic receptor binding in neonatal and adult rats.. Toxicology 170:1–10.
  • R.A. Huff, J.J. Corcoran, J.K. Anderson, and M.B. Abou-Donia. (1994). Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum.. J. Pharmacol. Exp. Ther. 269:329335.
  • R. Humbert, D.A. Adler, C.M. Disteche, C. Hassett, C.J. Omiecinski, and C.E. Furlong. (1993). The molecular basis of the human serum paraoxonase activity polymorphism.. Nat. Genet. 3:73–76.
  • D.L. Hunter, T.L. Lassiter, and S. Padilla. (1999). Gestational exposure to chlorpyrifos: Comparative distribution of trichloropyridinol in the fetus and dam.. Toxicol. Appl. Pharmacol. 158:16–23.
  • L.M. Icenogle, N.C. Christopher, W.P. Blackwelder, D.P. Caldwell, D. Qiao, F.J. Seidler, T.A. Slotkin, and E.D. Levin. (2004). Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.. Neurotoxicol. Teratol. 26:95–101.
  • N. Ito, A. Hagiwara, S. Tamano, M. Futacuchi, K. Imaida, and T. Shirai. (1996). Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis.. Food Chem. Toxicol. 34:1091–1096.
  • T. Iwasaki, M. Yoneda, A. Nakajima, and Y. Terauchi. (2007). Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance.. Intern. Med 46:1633–1639.
  • R.R. Jameson, F.J. Seidler, and T.A. Slotkin. (2007). Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: Chlorpyrifos, chlorpyrifos oxon, and diazinon.. Environ. Health Perspect. 115:65–70.
  • R.R. Jameson, F.J. Seidler, D. Qiao, and T.A. Slotkin. (2006). Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: Critical stages targeting differentiation in PC12 cells.. Environ. Health Perspect. 114:667–672.
  • D.A. Jett, R.V. Navoa, R.A. Beckles, and G.L. McLemore. (2001). Cognitive function and cholinergic neurochemistry in weanling rats exposed to chlorpyrifos.. Toxicol. Appl. Pharmacol. 174:89–98.
  • A. Johansen, E.M. Nielsen, G. Andersen, Y.H. Hamid, D.P. Jensen, C. Glümer, T. Drivsholm, K. Borch-Johnsen, T. Jørgensen, T. Hansen, and O. Pedersen. (2004). Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion.. Diabetologia 47:1437–1441.
  • C. Johansson, A.F. Castoldi, N. Onishchenko, L. Manzo, M. Vahter, and S. Ceccatelli. (2007). Neurobehavioural and molecular changes induced by methylmercury exposure during development.. Neurotoxicol. Res. 11:241–260.
  • D.E. Johnson, F.J. Seidler, and T.A. Slotkin. (1998). Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.. Brain Res. Bull. 45:143–147.
  • M.K. Johnson. (1990). Organophosphates and delayed neuropathy—Is NTE alive and well?. Toxicol. Appl. Pharmacol. 102:385–399.
  • M. Jokanovic. (2001). Biotransformation of organophosphorus compounds.. Toxicology 166:139–160.
  • H. Joo, K. Choi, R.L. Rose, and E. Hodgson. (2007). Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos.. J. Biochem. Mol. Toxicol. 21:76–80.
  • J.G. Kaplan, J. Kessler, N. Rosenberg, D. Pack, and H.H. Schaumburg. (1993). Sensory neuropathy associated with Dursban (chlorpyrifos) exposure.. Neurology 43:2193–2196.
  • S. Karanth, and C. Pope. (2000). Carboxylesterase and A-esterase activities during maturation and aging: Relationship to the toxicity of chlorpyrifos and parathion in rats.. Toxicol. Sci. 58:282–289.
  • S. Karanth, and C. Pope. (2003). Age-related effects of chlorpyrifos and parathion on acetylcholine synthesis in rat striatum.. Neurotoxicol. Teratol. 25:599–606.
  • J. Kawahara, J. Yoshinaga, and Y. Yanagisawa. (2007). Dietary exposure to organophosphorus pesticides for young children in Tokyo and neighboring area.. Sci. Total Environ. 378:263–268.
  • S.M. Kieszak, L.P. Naeher, C.S. Rubin, L.L. Needham, L. Backer, D. Barr, and M. McGeehin. (2002). Investigation of the relation between self-reported food consumption and household chemical exposures with urinary levels of selected nonpersistent pesticides.. J. Expos. Anal. Environ. Epidemiol. 12:404–408.
  • J.C. Kisicki, C.W. Seip, and M.L. Combs. A rising dose toxicology study to determine the no-observable effect levels (NOEL) for erythrocyte acetylcholinesterase (AChE) inhibition and cholinergic signs and symptoms of chlorpyrifos at three dose levels. Dow AgroSciences LLC, , (1999).
  • J.C. Kissel, C.L. Curl, G. Kedan, C. Lu, W. Griffith, D.B. Barr, L.L. Needham, and R.A. Fenske. (2005). Comparison of organophosphorus pesticide metabolite levels in single and multiple daily urine samples collected from preschool children in Washington State.. J. Expos. Anal. Environ. Epidemiol. 15:164–171.
  • A.A. Kousba, T.S. Poet, and C. Timchalk. (2007). Age-related brain cholinesterase inhibition kinetics following in vitro incubation with chlorpyrifos-oxon and diazinon-oxon.. Toxicol. Sci. 95:147–155.
  • R.I. Krieger, C.E. Bernard, T.M. Dinoff, L. Fell, T.G. Osimitz, J.H. Ross, and T. Ongsinthusak. (2000). Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals.. J. Expos. Anal. Environ. Epidemiol. 10:50–57.
  • R.I. Krieger, C.E. Bernard, T.M. Dinoff, J.H. Ross, and R.L. Williams. (2001). Biomonitoring of persons exposed to insecticides used in residences.. Ann Occup Hyg 45 (Suppl 1):S143–153.
  • R. Lane, H.H. Feldman, J. Meyer, Y. He, S.H. Ferris, A. Nordberg, T. Darreh-Shori, H. Soininen, T. Pirttilä, M.R. Farlow, N. Sfikas, C. Ballard, and N.H. Greig. (2008). Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.. Pharmacogenet Genomics 18:289–298.
  • R.M. Lane, S.G. Potkin, and A. Enz. (2006). Targeting acetylcholinesterase and butyrylcholinesterase in dementia.. Int. J. Neuropsychopharmacol 9:101–124.
  • C.L. Lanning, R.L. Fine, C.W. Sachs, U.S. Rao, J.J. Corcoran, and M.B. Abou-Donia. (1996). Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein. J. Toxicol. Environ. Health 47:395–407.
  • T.L. Lassiter, S. Padilla, S.M. Chanda, K. Das, N. Haykal-Coates, D. Hunter, R. Marshall, and S. BaroneJr.. (1998a). Dose response study of the effects of chlorpyrifos on various biochemical measures in the fetus and dam during late gestation.. Toxicologist 42:159.
  • T.L. Lassiter, S. Padilla, S.R. Mortensen, S.M. Chanda, V.C. Moser, and S. BaroneJr.. (1998b). Gestational exposure to chlorpyrifos: Apparent protection of the fetus?. Toxicol. Appl. Pharmacol. 152:56–65.
  • J. Latuszynska, S. Luty, G. Raszewski, M. Tokarska-Rodak, D. Przebirowska, E. Przylepa, and A. Haratym-Maj. (2001). Neurotoxic effect of dermally-applied chlorpyrifos and cypermethrin in Wistar rats.. Ann. Agric. Environ. Med. 8:163–170.
  • S. Lee, R. McLaughlin, M. Harnly, R. Gunier, and R. Kreutzer. (2002). Community exposures to airborne agricultural pesticides in California: Ranking of inhalation risks.. Environ. Health Perspect. 110:1175–1184.
  • W.J. Lee, A. Blair, J.A. Hoppin, J.H. Lubin, J.A. Rusiecki, D.P. Sandler, M. Dosemeci, and M.C. Alavanja. (2004). Cancer incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.. JNCI 96:1781–1789.
  • W.J. Lee, J.S. Colt, E.F. Heineman, R. McComb, D.D. Weisenburger, W. Lijinsky, and M.H. Ward. (2005). Agricultural pesticide use and risk of glioma in Nebraska, United States.. Occup. Environ. Med. 62:786–792.
  • W.J. Lee, D.P. Sandler, A. Blair, C. Samanic, A.J. Cross, and M.C. Alavanja. (2007). Pesticide use and colorectal cancer risk in the Agricultural Health Study.. Int.J. Cancer 121:339–346.
  • C. Lentner. Geigy Scientific Tables. Ciba Geigy Corporation, West CaldwellNJ, (1981).
  • I. Leviev, and R.W. James. (2000). Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations.. Arterioscler. Thromb. Vasc. Biol. 20:516–521.
  • E.D. Levin, N. Addy, A. Baruah, A. Elias, N.C. Christopher, F.J. Seidler, and T.A. Slotkin. (2002). Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.. Neurotoxicol. Teratol. 24:733–741.
  • R.G. Lewis, R.C. Fortmann, and D.E. Camann. (1994). Evaluation of methods for monitoring the potential exposure of small children to pesticides in the residential environment.. Arch. Environ. Contam. Toxicol. 26:37–46.
  • B. Li, M. Sedlacek, I. Manoharan, R. Boopathy, E.G. Duysen, P. Masson, and O. Lockridge. (2005). Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma.. Biochem. Pharmacol. 70:1673–1684.
  • B. Li, E.G. Duysen, and O. Lockridge. (2008). The butyrylcholinesterase knockout mouse is obese on a high-fat diet. Chem Biol Interact. in press
  • W.F. Li, L.G. Costa, and C.E. Furlong. (1993). Serum paraoxonase status: A major factor in determining resistance to organophosphates.. J. Toxicol. Environ. Health 40:337–346.
  • W.F. Li, L.G. Costa, R.J. Richter, T. Hagen, D.M. Shih, A. Tward, A.J. Lusis, and C.E. Furlong. (2000). Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds.. Pharmacogenetics 10:767–779.
  • W.F. Li, C.E. Furlong, and L.G. Costa. (1995). Paraoxonase protects against chlorpyrifos toxicity in mice.. Toxicol. Lett. 76:219–226.
  • W.F. Li, C. Matthews, C.M. Disteche, L.G. Costa, and C.E. Furlong. (1997). Paraoxonase (PON1) gene in mice: Sequencing, chromosomal localization and developmental expression.. Pharmacogenetics 7:137–144.
  • W. Li, and J.E. Casida. (1998). Organophosphorus neuropathy target esterase inhibitors selectively block outgrowth of neurite-like and cell processes in cultured cells.. Toxicol. Lett. 98:139–146.
  • Z. Li, R. Yang, and Z. Chen. (1996). [Effects of iodine and thyroid hormone deficiency during brain development on activities of cholinergic neurone-related enzymes in central nervous system of rats].. Zhonghua Yu Fang Yi Xue Za Zhi 30:337–339.
  • A.D. Lieberman, M.R. Craven, H.A. Lewis, and J.H. Nemenzo. (1998). Genotoxicity from domestic use of organophosphate pesticides.. J. Occup. Environ. Med. 40:954–957.
  • P.J. Lioy, R.D. Edwards, N. Freeman, S. Gurunathan, E. Pellizzari, J.L. Adgate, J. Quackenboss, and K. Sexton. (2000). House dust levels of selected insecticides and a herbicide measured by the EL and LWW samplers and comparisons to hand rinses and urine metabolites.. J. Expos. Anal. Environ. Epidemiol. 10:327–340.
  • J. Liu, and C.N. Pope. (1996). Effects of chlorpyrifos on high-affinity choline uptake and [3H]hemicholinium-3 binding in rat brain.. Fundam. Appl. Toxicol. 34:84–90.
  • J. Liu, T. Chakraborti, and C. Pope. (2002). In vitro effects of organophosphorus anticholinesterases on muscarinic receptor-mediated inhibition of acetylcholine release in rat striatum.. Toxicol. Appl. Pharmacol. 178:102–108.
  • J. Liu, K. Olivier, and C.N. Pope. (1999). Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats.. Toxicol. Appl. Pharmacol. 158:186–196.
  • Y. Loewenstein-Lichtenstein, M. Schwarz, D. Glick, B. Norgaard-Pedersen, H. Zakut, and H. Soreq. (1995). Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers.. Nat. Med. 1:1082–1085.
  • G.G. Long, A.B. Scheidt, R.J. Everson, and F.W. Oehme. (1986). Age related susceptibility of newborn pigs to the cutaneous application of chlorpyrifos.. Vet. Hum. Toxicol. 28:297–299.
  • M. Lotti. (1991). The pathogenesis of organophosphate delayed polyneuropathy. Crit. Rev. Toxicol 21:465–487.
  • M. Lotti. Organophosphate compounds, Experimental and Clinical NeurotoxicologyP.S. Spencer, and H.S. Schaumburg. Oxford University Press, New York, (2000)897.
  • M. Lotti, and A. Moretto. (2005). Organophosphate-induced delayed polyneuropathy.. Toxicol. Rev. 24:37–49.
  • M. Lotti, A. Moretto, R. Zoppellari, R. Dainese, N. Rizzuto, and G. Barusco. (1986). Inhibition of lymphocytic neuropathy target esterase predicts the development of organophosphate-induced delayed polyneuropathy.. Arch. Toxicol. 59:176–179.
  • C. Lu, and R.A. Fenske. (1998). Air and surface chlorpyrifos residues following residential broadcast and aerosol pesticide applications.. Environ. Sci. Technol. 32:1386–1390.
  • C. Lu, and R.A. Fenske. (1999). Dermal transfer of chlorpyrifos residues from residential surfaces: Comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications.. Environ. Health Perspect. 107:463–467.
  • C. Lu, G. Kedan, J. Fisker-Andersen, J.C. Kissel, and R.A. Fenske. (2004). Multipathway organophosphorus pesticide exposures of preschool children living in agricultural and nonagricultural communities.. Environ. Res. 96:283–289.
  • C. Lu, K. Toepel, R. Irish, R.A. Fenske, D.B. Barr, and R. Bravo. (2006). Organic diets significantly lower children's dietary exposure to organophosphorus pesticides.. Environ. Health Perspect. 114:260–263.
  • C. Lu, D.B. Barr, M.A. Pearson, and L.A. Waller. (2008). Dietary intake and its contribution to longitudinal organophosphorour pesticide exposure in urban/suburban children. Environ. Health Perspect. 116:537–542.
  • T. Ma, and J.E. Chambers. (1994). Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes.. Food Chem. Toxicol. 32:763–767.
  • D.L. MacIntosh, C.W. Kabiru, and P.B. Ryan. (2001b). Longitudinal investigation of dietary exposure to selected pesticides.. Environ. Health Perspect. 109:145–150.
  • D.L. MacIntosh, C. Kabiru, S.L. Echols, and P.B. Ryan. (2001a). Dietary exposure to chlorpyrifos and levels of 3,5,6-trichloro-2-pyridinol in urine.. J. Expos. Anal. Environ. Epidemiol. 11:279–285.
  • B. Mackness, P.N. Durrington, and M.I. Mackness. (2000). Low paraoxonase in Persian Gulf War Veterans self-reporting Gulf War Syndrome.. Biochem. Biophys. Res. Commun. 276:729–733.
  • B. Mackness, P. Durrington, A. Povey, S. Thomson, M. Dippnall, M. Mackness, T. Smith, and N. Cherry. (2003). Paraoxonase and susceptibility to organophosphorus poisoning in farmers dipping sheep.. Pharmacogenetics 13:81–88.
  • D.T. Mage. (2006). Dermal absorption of chlorpyrifos.. Ann. Occup. Hyg 50:638–639.
  • J.S. Mandel, B.H. Alexander, B.A. Baker, J.F. Acquavella, P. Chapman, and R. Honeycutt. (2005). Biomonitoring for farm families in the farm family exposure study.. Scand. J. Work Environ. Health 31 (Suppl 1):98–104. discussion 163–105.
  • M.S. Marty, J.Y. Domoradzki, S.C. Hansen, C. Timchalk, M.J. Bartels, and J.L. Mattsson. (2007). The effect of route, vehicle, and divided doses on the pharmacokinetics of chlorpyrifos and its metabolite trichloropyridinol in neonatal Sprague-Dawley rats.. Toxicol. Sci. 100:360–373.
  • I. Mateo, J. Llorca, J. Infante, E. Rodríguez-Rodríguez, J. Berciano, and O. Combarros. (2008). Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk.. Eur. J. Neurol 15:219–222.
  • J.L. Mattsson, J.W. Wilmer, M.R. Shankar, N.M. Berdasco, J.W. Crissman, J.P. Maurissen, and D.M. Bond. (1996). Single-dose and 13-week repeated-dose neurotoxicity screening studies of chlorpyrifos insecticide.. Food Chem. Toxicol 34:393–405.
  • J.L. Mattsson, J.P. Maurissen, R.J. Nolan, and K.A. Brzak. (2000). Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos.. Toxicol. Sci. 53:438–446.
  • J.P. Maurissen, A.M. Hoberman, R.H. Garman, and T.R. HanleyJr.. (2000). Lack of selective developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos.. Toxicol. Sci. 57:250–263.
  • S.B. McCollister, R.J. Kociba, C.G. Humiston, D.D. McCollister, and P.J. Gehring. (1974). Studies of the acute and long-term oral toxicity of chlorpyrifos (O,O-diethyl-O(3,5,6-trichloro-2-pyridyl) phosphorothioate).. Food Cosmet. Toxicol 12:45–61.
  • M.C. McGuire, C.P. Nogueira, C.F. Bartels, H. Lightstone, A. Hajra, A.F. Van der Spek, O. Lockridge, and B.N. La Du. (1989). Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.. Proc. Natl. Acad. Sci. USA 86:953–957.
  • J.D. Meeker, D.B. Barr, and R. Hauser. (2006a). Thyroid hormones in relation to urinary metabolites of non-persistent insecticides in men of reproductive age.. Reprod. Toxicol. 22:437–442.
  • J.D. Meeker, D.B. Barr, L. Ryan, R.F. Herrick, D.H. Bennett, R. Bravo, and R. Hauser. (2005). Temporal variability of urinary levels of nonpersistent insecticides in adult men.. J. Expos. Anal. Environ. Epidemiol. 15:271–281.
  • J.D. Meeker, L. Ryan, D.B. Barr, and R. Hauser. (2006b). Exposure to nonpersistent insecticides and male reproductive hormones.. Epidemiology 17:61–68.
  • J.D. Meeker, L. Ryan, D.B. Barr, R.F. Herrick, D.H. Bennett, R. Bravo, and R. Hauser. (2004a). The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality.. Environ. Health Perspect. 112:1665–1670.
  • J.D. Meeker, N.P. Singh, L. Ryan, S.M. Duty, D.B. Barr, R.F. Herrick, D.H. Bennett, and R. Hauser. (2004b). Urinary levels of insecticide metabolites and DNA damage in human sperm.. Hum. Reprod. 19:2573–2580.
  • W.J. Meggs. (2003). Permanent paralysis at sites of dermal exposure to chlorpyrifos.. J. Toxicol. Clin. Toxicol. 41:883–886.
  • S.M. Mense, A. Sengupta, C. Lan, M. Zhou, G. Bentsman, D.J. Volsky, R.M. Whyatt, F.P. Perera, and L. Zhang. (2006). The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes.. Toxicol. Sci. 93:125–135.
  • W.J.A. Meuling, L.C. Ravensberg, L. Roza, and J.J. van Hemmen. (2005). Dermal absorption of chlorpyrifos in human volunteers.. Int. Arch. Occup. Environ. Health 78:44–50.
  • A. Meyer, F.J. Seidler, J.E. Aldridge, and T.A. Slotkin. (2005). Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos.. Toxicol. Appl. Pharmacol. 203:154–166.
  • A. Meyer, F.J. Seidler, J.E. Aldridge, C.A. Tate, M.M. Cousins, and T.A. Slotkin. (2004). Critical periods for chlorpyrifos-induced developmental neurotoxicity: Alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure.. Environ. Health Perspect. 112:295–301.
  • A. Meyer, F.J. Seidler, M.M. Cousins, and T.A. Slotkin. (2003). Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: When is adenylyl cyclase a target?. Environ. Health Perspect. 111:1871–1876.
  • H. Michalek, A. Meneguz, and G.M. Bisso. (1982). Mechanisms of recovery of brain acetylcholinesterase in rats during chronic intoxication by isoflurophate.. Arch. Toxicol. Suppl. 5:116–119.
  • L.R. Mikami, S. Wieseler, R.L. Souza, L.M. Schopfer, F. Nachon, O. Lockridge, and E.A. Chautard-Freire-Maia. (2008). Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population.. Pharmacogenet. Genom 18:213–218.
  • J. Miranda, I. Lundberg, R. McConnell, E. Delgado, R. Cuadra, E. Torres, C. Wesseling, and M. Keifer. (2002a). Onset of grip-and pinch-strength impairment after acute poisonings with organophosphate insecticides.. Int. J. Occup. Environ. Health 8:19–26.
  • J. Miranda, R. McConnell, E. Delgado, R. Cuadra, M. Keifer, C. Wesseling, E. Torres, and I. Lundberg. (2002b). Tactile vibration thresholds after acute poisonings with organophosphate insecticides.. Int. J. Occup. Environ. Health 8:212–219.
  • K.E. Misulis, J. Sussman, S. Bon, and I. Silman. (1993). Structure and functions of acetylcholinesterase and butyrylcholinesterase.. Prog. Brain Res 98:139.
  • F. Monnet-Tschudi, M.G. Zurich, B. Schilter, L.G. Costa, and P. Honegger. (2000). Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures.. Toxicol. Appl. Pharmacol. 165:175–183.
  • A. Moretto, and M. Lotti. (1998). Poisoning by organophosphorus insecticides and sensory neuropathy.. J. Neurol. Neurosurg. Psychiatry 64:463–468.
  • M.K. Morgan, L.S. Sheldon, C.W. Croghan, P.A. Jones, G.L. Robertson, J.C. Chuang, N.K. Wilson, and C.W. Lyu. (2005). Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments.. J. Expos. Anal. Environ. Epidemiol. 15:297–309.
  • M. Moriya, T. Ohta, K. Watanabe, T. Miyazawa, K. Kato, and Y. Shirasu. (1983). Further mutagenicity studies on pesticides in bacterial reversion assay systems.. Mutat. Res. 116:185–216.
  • S.R. Mortensen, S. Brimijoin, M.J. Hooper, and S. Padilla. (1998a). Comparison of the in vitro sensitivity of rat acetylcholinesterase to chlorpyrifos-oxon: What do tissue IC50 values represent?. Toxicol. Appl. Pharmacol. 148:46–49.
  • S.R. Mortensen, S.M. Chanda, and S. Padilla. (1996b). Age-related sensitivity to the anticholinesterase pesticide chlorpyrifos studies on the developmental changes in acetylcholinesterase AChE and a-esterase arylesterase activities.. J. Neurochemistry 66:S17.
  • S.R. Mortensen, S.M. Chanda, M.J. Hooper, and S. Padilla. (1996a). Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos.. J. Biochem. Toxicol. 11:279–287.
  • S.R. Mortensen, M.J. Hooper, and S. Padilla. (1998b). Rat brain acetylcholinesterase activity: Developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors.. Toxicology 125:13–19.
  • D.J. Moschandreas, S. Karuchit, M.R. Berry, M.K. O'Rourke, D. Lo, M.D. Lebowitz, and G. Robertson. (2002). Exposure apportionment: Ranking food items by their contribution to dietary exposure.. J. Expos. Anal. Environ. Epidemiol. 12:233–243.
  • D.J. Moschandreas, S. Karuchit, Y. Kim, H. Ari, M.D. Lebowitz, O.R. MK, S. Gordon, and G. Robertson. (2001a). On predicting multi-route and multimedia residential exposure to chlorpyrifos and diazinon.. J. Expos. Anal. Environ. Epidemiol. 11:56–65.
  • D.J. Moschandreas, Y. Kim, S. Karuchit, H. Ari, M.D. Lebowitz, M.K. O'Rourke, S. Gordon, and G. Robertson. (2001b). In-residence, multiple route exposures to chlorpyrifos and diazinon estimated by indirect method models.. Atmos. Environ. 35:2201–2213.
  • N. Moser, A. Wevers, D.E. Lorke, S. Reinhardt, A. Maelicke, and H. Schroder. (1996). Alpha4-1 subunit mRNA of the nicotinic acetylcholine receptor in the rat olfactory bulb: Cellular expression in adult, pre-and postnatal stages.. Cell Tissue Res. 285:17–25.
  • V.C. Moser. (1998). Age-related differences in aldicarb neurotoxicity in the rat.. Neurotoxicol. Teratol. 20:364.
  • V.C. Moser. (2000). Dose-response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages.. Neurotoxicol. Teratol. 22:713–723.
  • V.C. Moser, and S. Padilla. (1998). Age-and gender-related differences in the time course of behavioral and biochemical effects produced by oral chlorpyrifos in rats.. Toxicol. Appl. Pharmacol. 149:107–119.
  • V.C. Moser, S.M. Chanda, S.R. Mortensen, and S. Padilla. (1998). Age-and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities.. Toxicol. Sci. 46:211–222.
  • R.F. Mueller, S. Hornung, C.E. Furlong, J. Anderson, E.R. Giblett, and A.G. Motulsky. (1983). Plasma paraoxonase polymorphism: A new enzyme assay, population, family, biochemical, and linkage studies.. Am.J. Hum. Genet. 35:393–408.
  • S.D. Murphy. (1982). Toxicity and hepatic metabolism of organophosphate insecticides in developing rats.. Banbury Rep. 11:125–136.
  • D.E. Muscarella, J.F. Keown, and S.E. Bloom. (1984). Evaluation of the genotoxic and embryotoxic potential of chlorpyrifos and its metabolites in vivo and in vitro.. Environ. Mutagen. 6:13–23.
  • E. Mutch, and F.M. Williams. (2004). Do multiple P450 isoforms contribute to parathion, diazinon and chlorpyrifos metabolism in man?. Drug Metab. Rev. 36:265.
  • E. Mutch, and F.M. Williams. (2006). Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver.. Toxicology 224:22–32.
  • M.C. Nelson, S.M. Jalal, and O.R. Larson. (1990). Genotoxicity of the organophosphorous insecticide chlorpyrifos based on human lymphocyte culture. Cytologia (Tokyo) 55:588–592.
  • NHANES III. Third National Health and Nutrition Examination Survey. National Center for Health Statistics Centers for Disease Control and Prevention, AtlantaGA, (2003).
  • L.L. Needham. (2005). Assessing exposure to organophosphorous pesticides by biomonitoring in epidemiological studies of birth outcomes.. Environ. Health Perspect. 113:494–498.
  • Z. Ni, S. Li, Y. Liu, Y. Tang, and D. Pang. (1993). [Induction of micronucleus by organophosphorus pesticides both in vivo and in vitro].. Hua Xi Yi Ke Da Xue Xue Bao 24:82–86.
  • NIOSH. Occupational Safety and Health Guidelines for Chlorpyrifos. National Institute for Occupational Safety and Health, CincinnatiOH, (1995).
  • R.J. Nolan, D.L. Rick, N.L. Freshour, and J.H. Saunders. (1984). Chlorpyrifos: Pharmacokinetics in human volunteers.. Toxicol. Appl. Pharmacol. 73:8–15.
  • D.K. Nomura, K.A. Durkin, K.P. Chiang, G.B. Quistad, B.F. Cravatt, and J.E. Casida. (2006). Serine hydrolase KIAA1363: Toxicological and structural features with emphasis on organophosphate interactions.. Chem. Res. Toxicol. 19:1142–1150.
  • K. OlivierJr., J. Liu, and C. Pope. (2001). Inhibition of forskolin-stimulated cAMP formation in vitro by paraoxon and chlorpyrifos oxon in cortical slices from neonatal, juvenile, and adult rats.. J. Biochem. Mol. Toxicol. 15:263–269.
  • M. Oncu, F. Gultekin, E. Karaoz, I. Altuntas, and N. Delibas. (2002). Nephrotoxicity in rats induced by chlorpryfos-ethyl and ameliorating effects of antioxidants.. Hum. Exp. Toxicol. 21:223–230.
  • J. Osterloh, M. Lotti, and S.M. Pond. (1983). Toxicologic studies in a fatal overdose of 2,4-D, MCPP, and chlorpyrifos.. J. Anal. Toxicol. 7:125–129.
  • E.M. Ostrea, V. Morales, E. Ngoumgna, R. Prescilla, E. Tan, E. Hernandez, G.B. Ramirez, H.L. Cifra, and M.L. Manlapaz. (2002). Prevalence of fetal exposure to environmental toxins as determined by meconium analysis.. Neurotoxicology 23:329–339.
  • E.M. OstreaJr., D.M. Bielawski, N.C. PosecionJr., M. Corrion, E. Villanueva-Uy, Y. Jin, J.J. Janisse, and J.W. Ager. (2008). A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides.. Environ. Res 106:277–283.
  • S. Padilla, J. Buzzard, and V.C. Moser. (2000). Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos.. Neurotoxicology 21:49–56.
  • Y. Pang, D.L. MacIntosh, D.E. Camann, and P.B. Ryan. (2002). Analysis of aggregate exposure to chlorpyrifos in the NHEXAS-Maryland investigation.. Environ. Health Perspect. 110:235–240.
  • K.K. Patnaik, and N.K. Tripathy. (1992). Farm-grade chlorpyrifos (Durmet) is genotoxic in somatic and germ-line cells of Drosophila.. Mutat. Res. 279:15–20.
  • E.D. Pellizzari, D.J. Smith, A.C. Clayton, and J.J. Quackenboss. (2003). Assessment of data quality for the NHEXAS—Part II: Minnesota chlidren's pesticide exposure study (MNCPES).. J. Expos. Anal. Environ. Epidemiol. 13:465–479.
  • F.P. Perera, V. Rauh, W.Y. Tsai, P. Kinney, D. Camann, D. Barr, T. Bernert, R. Garfinkel, Y.H. Tu, D. Diaz, J. Dietrich, and R.M. Whyatt. (2003). Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population.. Environ. Health Perspect. 111:201–205.
  • F.P. Perera, V. Rauh, R.M. Whyatt, D. Tang, W.Y. Tsai, J.T. Bernert, Y.H. Tu, H. Andrews, D.B. Barr, D.E. Camann, D. Diaz, J. Dietrich, A. Reyes, and P.L. Kinney. (2005). A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures.. Neurotoxicology 26:573–587.
  • F.P. Perera, V. Rauh, R.M. Whyatt, W.Y. Tsai, D. Tang, D. Diaz, L. Hoepner, D. Barr, Y.H. Tu, D. Camann, and P. Kinney. (2006). Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children.. Environ. Health Perspect. 114:1287–1292.
  • F. Perera, V.A. Rauh, D. Tang, D.B. Barr, D. Camann, P.L. Kinney, H. Andrew, and R.M. Whyatt. (2004). Relationship between prenatal environ-mental exposures, birth outcomes and cognitive development in an urban minority cohort.. Neurotoxicology (Amsterdam) 25:667–668.
  • J.R. Playfer, C. Powell, and D.A. Evans. (1977). Plasma paroxonase activity in old age.. Age Ageing 6:89–95.
  • E. Podoly, T. Bruck, S. Diamant, N. Melamed-Book, A. Weiss, Y. Huang, O. Livnah, S. Langermann, H. Wilgus, and H. Soreq. (2008). Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro.. Neurodegener Dis 5:232–236.
  • C.N. Pope. (2005). Organophosphorus and carbamate cholinesterase inhibitors: Uses and misuses of a common mechanism.. Toxicol. Sci. 84:204.
  • C.N. Pope, and T.K. Chakraborti. (1992). Dose-related inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures.. Toxicology 73:35–43.
  • C.N. Pope, and J. Liu. (1997). Age-related differences in sensitivity to organophosphorus pesticides.. Environ. Toxicol. Pharmacol. 4:309–314.
  • C.N. Pope, T.K. Chakraborti, M.L. Chapman, J.D. Farrar, and D. Arthun. (1991a). Comparison of In vivo Cholinesterase Inhibition in Neonatal and Adult Rats by Three Organophosphorothioate Insecticides. NTIS/PB92-110550, 110513. Govt Reports Announcements & Index Issue 02, 1992
  • C.N. Pope, T.K. Chakraborti, M.L. Chapman, J.D. Farrar, and D. Arthun. (1991b). Comparison of in vivo cholinesterase inhibition in neonatal and adult rats by three organophosphorothioate insecticides.. Toxicology 68:51–61.
  • C.N. Pope, S. Karanth, J. Liu, and B. Yan. (2005). Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon.. Regul. Toxicol. Pharmacol. 42:64–69.
  • P. Poulin, and K. Krishnan. (1995). An algorithm for predicting tissue: Blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data.. J. Toxicol. Environ. Health 46:117–129.
  • M.A. Prendergast, R.L. Self, K.J. Smith, L. Ghayoumi, M.M. Mullins, T.R. Butler, J.J. Buccafusco, D.A. Gearhart, and A.V. TerryJr.. (2007). Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity.. Neuroscience 146:330–339.
  • D. Qiao, F.J. Seidler, Y. Abreu-Villaca, C.A. Tate, M.M. Cousins, and T.A. Slotkin. (2004). Chlorpyrifos exposure during neurulation: Cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood.. Brain Res. Dev. Brain Res. 148:43–52.
  • D. Qiao, F.J. Seidler, and T.A. Slotkin. (2001). Developmental neurotoxicity of chlorpyrifos modeled in vitro: Comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.. Environ. Health Perspect. 109:909–913.
  • D. Qiao, F.J. Seidler, and T.A. Slotkin. (2002b). Developmental neurotoxicity of chlorpyrifos: Defining the vulnerable period.. Toxicologist 66:130–131.
  • D. Qiao, F.J. Seidler, E.D. Levin, S. Padilla, and T.A. Slotkin. (2002a). Developmental neurotoxicity of chlorpyrifos: Defining the vulnerable period.. FASEB J. 16:A949.
  • D. Qiao, F.J. Seidler, C.A. Tate, M.M. Cousins, and T.A. Slotkin. (2003). Fetal chlorpyrifos exposure: Adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.. Environ. Health Perspect. 111:536–544.
  • J.J. Quackenboss, E.D. Pellizzari, P. Shubat, R.W. Whitmore, J.L. Adgate, K.W. Thomas, N.C. Freeman, C. Stroebel, P.J. Lioy, A.C. Clayton, and K. Sexton. (2000). Design strategy for assessing multi-pathway exposure for children: The Minnesota Children's Pesticide Exposure Study (MNCPES).. J. Expos. Anal. Environ. Epidemiol. 10:145–158.
  • J.H. Quellette, D.A. Dittenber, P.M. Kloes, and J.A. John. Chlorpyrifos: Oral teratology study in Fisher 344 rats. Study K-44793-47, Tox. Res. Lab. Dow. , MidlandMI, (1983).
  • G.B. Quistad, R. Klintenberg, P. Caboni, S.N. Liang, and J.E. Casida. (2006a). Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice.. Toxicol. Appl. Pharmacol. 211:78–83.
  • G.B. Quistad, S.N. Liang, K.J. Fisher, D.K. Nomura, and J.E. Casida. (2006b). Each lipase has a unique sensitivity profile for organophosphorus inhibitors.. Toxicol. Sci. 91:166–172.
  • G.B. Quistad, D.K. Nomura, S.E. Sparks, Y. Segall, and J.E. Casida. (2002). Cannabinoid CB1 receptor as a target for chlorpyrifos oxon and other organophosphorus pesticides.. Toxicol. Lett. 135:89–93.
  • G.B. Quistad, S.E. Sparks, and J.E. Casida. (2001). Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides.. Toxicol. Appl. Pharmacol. 173:48–55.
  • M.F. Rahman, M. Mahboob, K. Danadevi, B. Saleha Banu, and P. Grover. (2002). Assessment of genotoxic effects of chloropyriphos and acephate by the comet assay in mice leucocytes.. Mutat. Res. 516:139–147.
  • K.W. Raines, F.J. Seidler, and T.A. Slotkin. (2001). Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos.. Brain Res. Dev. Brain Res. 130:65–72.
  • V. Ramirez, and P. Cuenca. (2002). [DNA damage in female workers exposed to pesticides in banana plantations at Limon, Costa Rica].. Rev. Biol. Trop. 50:507–518.
  • V.A. Rauh, R. Garfinkel, F.P. Perera, H.F. Andrews, L. Hoepner, D.B. Barr, R. Whitehead, D. Tang, and R.W. Whyatt. (2006). Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.. Pediatrics 118:e1845–1859.
  • V.A. Rauh, D. Tang, D.B. Barr, D. Camann, P.L. Kinney, H. Andrews, and R.M. Whyatt. (2004b). Relationship between prenatal environmental exposures, birth outcomes and cognitive development in an urban minority cohort.. Neurotoxicology 25:667–668.
  • V. Rauh, F. Perera, D. Tang, D.B. Barr, D. Camann, P.L. Kinney, H. Andrews, and R.M. Wyatt. (2004a). Relationship between prenatal environmental exposures, birth outcomes and cognitive development in an urban minority cohort.. Epidemiology 15:S87.
  • D.F.K. Rawn, and D.C.G. Muir. (1999). Sources of chlorpyrifos and dacthal to a small Canadian prairie watershed.. Environ. Sci. Technol 33:3317–3323.
  • M.C. Rhodes, F.J. Seidler, D. Qiao, C.A. Tate, M.M. Cousins, and T.A. Slotkin. (2004). Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats.. Toxicol. Appl. Pharmacol. 195:203–217.
  • L. Ricceri, N. Markina, A. Valanzano, S. Fortuna, M.F. Cometa, A. Meneguz, and G. Calamandrei. (2003). Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice.. Toxicol. Appl. Pharmacol. 191:189–201.
  • L. Ricceri, A. Venerosi, F. Capone, M.F. Cometa, P. Lorenzini, S. Fortuna, and G. Calamandrei. (2006). Developmental neurotoxicity of organophosphorous pesticides: Fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice.. Toxicol. Sci. 93:105–113.
  • J.R. Richardson, and J.E. Chambers. (2003). Effects of repeated developmental exposure to chlorpyrifos on presynaptic neurochemical components of the cholinergic system.. Neurotoxicology (Little Rock) 24:305.
  • J.R. Richardson, and J.E. Chambers. (2004). Neurochemical effects of repeated gestational exposure to chlorpyrifos in developing rats.. Toxicol. Sci. 77:83–90.
  • J.R. Richardson, and J.E. Chambers. (2005). Effects of repeated oral postnatal exposure to chlorpyrifos on cholinergic neurochemistry in developing rats.. Toxicol. Sci. 84:352–359.
  • R.J. Richter, and C.E. Furlong. (1999). Determination of paraoxonase (PON1) status requires more than genotyping.. Pharmacogenetics 9:745–753.
  • M.L. Rigas, M.S. Okino, and J.J. Quackenboss. (2001). Use of a pharmacokinetic model to assess chlorpyrifos exposure and dose in children, based on urinary biomarker measurements.. Toxicol. Sci. 61:374–381.
  • G.L. Robertson, M.D. Lebowitz, M.K. O'Rourke, S. Gordon, and D. Moschandreas. (1999). The National Human Exposure Assessment Survey (NHEXAS) study in Arizona—Introduction and preliminary results.. J. Expos. Anal. Environ. Epidemiol. 9:427–434.
  • G.S. Rodrigues, D. Pimentel, and L.H. Weinstein. (1998). In situ assessment of pesticide genotoxicity in an integrated pest management program: II. Maize waxy mutation assay.. Mutat. Res. 412:245–250.
  • T. Rodriguez, L. Younglove, C. Lu, A. Funez, S. Weppner, D.B. Barr, and R.A. Fenske. (2006). Biological monitoring of pesticide exposures among applicators and their children in Nicaragua.. Int.J. Occup. Environ. Health 12:312–320.
  • R.L. Rose, and E. Hodgson. (2005). Pesticide metabolism and potential for metabolic interactions.. J. Biochem. Mol. Toxicol. 19:276–277.
  • R.L. Rose, J. Tang, J. Choi, Y. Cao, A. Usmani, N. Cherrington, and E. Hodgson. (2005). Pesticide metabolism in humans, including polymorphisms.. Scand.J. Work Environ. Health 31 (Suppl 1):156–163. discussion 119–122
  • M.K. Ross, and J.A. Crow. (2007). Human carboxylesterases and their role in xenobiotic and endobiotic metabolism.. J. Biochem. Mol. Toxicol. 21:187–196.
  • T.S. Roy, J.E. Andrews, F.J. Seidler, and T.A. Slotkin. (1998). Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos.. Teratology 58:62–68.
  • T.S. Roy, F.J. Seidler, and T.A. Slotkin. (2004). Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: Regionally selective alterations in neurons and glia.. Brain Res. Dev. Brain Res. 148:197–206.
  • T.S. Roy, V. Sharma, F.J. Seidler, and T.A. Slotkin. (2005). Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats.. Brain Res. Dev. Brain Res. 155:71–80.
  • Y. Rubin, N. Gal, T. Waner, and A. Nyska. Pyrinex, teratogenicity study in the rat. Life Science Res. Israel Ltd., Ness ZionaIsrael, (1987a).
  • Y. Rubin, A. Nyska, and T. Waner. Pyrnex, teratogenicity study in the rabbit. Life Science Res. Ltd., Ness ZionaIsrael, (1987b).
  • R.P. Rull, B. Ritz, and G.M. Shaw. (2006). Neural tube defects and maternal residential proximity to agricultural pesticide applications.. Am.J. Epidemiol. 163:743–753.
  • M. Sachana, J. Flaskos, E. Alexaki, P. Glynn, and A.J. Hargreaves. (2001a). The toxicity of chlorpyrifos towards differentiating mouse N2a neuroblastoma cells.. Toxicol. In Vitro 15:369–372.
  • M. Sachana, J. Flaskos, and A.J. Hargreaves. (2005). Effects of Chlorpyrifos and Chlorpyrifos-Methyl on the Outgrowth of Axon-Like Processes, Tubulin, and GAP-43 in N2a Cells. Toxicol. Mechanisms Methods 15:405–410.
  • M. Sachana, J. Flaskos, E. Nikolaidis, A. Hargreaves, and E. Alexaki-Tzivanidou. (2001b). Inhibition of rat platelet 5-hydroxytryptamine uptake by chlorpyrifos and carbaryl.. Pharmacol. Toxicol. 89:195–200.
  • C. Sams, J. Cocker, and M.S. Lennard. (2004). Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP).. Xenobiotica 34:861–873.
  • C. Sams, H.J. Mason, and R. Rawbone. (2000). Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes.. Toxicol. Lett. 116:217–221.
  • T.E. Samsam, D.L. Hunter, and P.J. Bushnell. (2005). Effects of chronic dietary and repeated acute exposure to chlorpyrifos on learning and sustained attention in rats. Toxicol.. Sci 87:460–468.
  • S.S. Sandhu, M.D. Waters, V.F. Simmon, K.E. Mortelmans, A.D. Mitchell, T. Jorgenson, D.L. Jones, R. Valencia, and F. Stack. (1985). Evaluation of the genotoxic potential of certain pesticides used in Pakistan. Basic and applied mutagenesis.. Basic Life Sci. 34:185–219.
  • R. Sanghi, M.K. Pillai, T.R. Jayalekshmi, and A. Nair. (2003). Organochlorine and organophosphorus pesticide residues in breast milk from Bhopal, Madhya Pradesh, India.. Hum. Exp. Toxicol. 22:73–76.
  • T. Satoh, and M. Hosokawa. (1998). The mammalian carboxylesterases: From molecules to functions.. Annu. Rev. Pharmacol. Toxicol. 38:257–288.
  • T. Satoh, P. Taylor, W.F. Bosron, S.P. Sanghani, M. Hosokawa, and B.N. La Du. (2002). Current progress on esterases: From molecular structure to function.. Drug Metab. Dispos. 30:488–493.
  • D.P. Scher, B.H. Alexander, J.L. Adgate, L.E. Eberly, J.S. Mandel, J.F. Acquavella, M.J. Bartels, and K.A. Brzak. (2007). Agreement of pesticide biomarkers between morning void and 24-h urine samples from farmers and their children.. J. Expos. Sci. Environ. Epidemiol. 17:350–357.
  • W. Schmid. The micronucleus test for cytogenetic analysis, Chemical Mutagens: Principles and Methods for their DetectionA. Hollaender. Plenum, New York, (1976)Vol. 431–53.
  • R.A. Schuh, P.J. Lein, R.A. Beckles, and D.A. Jett. (2002). Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: Altered phosphorylation of Ca2 +/cAMP response element binding protein in cultured neurons. Toxicol. Appl. Pharmacol. 182:176–185.
  • N. Senanayake. (1981). Tri-cresyl phosphate neuropathy in Sri Lanka: A clinical and neurophysiological study with a three year follow up.. J. Neurol. Neurosurg. Psychiatry 44:775–780.
  • K. Sexton, J.L. Adgate, L.E. Eberly, C.A. Clayton, R.W. Whitmore, E.D. Pellizzari, P.J. Lioy, and J.J. Quackenboss. (2003). Predicting children's short-term exposure to pesticides: Results of a questionnaire screening approach.. Environ. Health Perspect. 111:123–128.
  • , J.D. Sherman. (1995). Organophosphate pesticides—Neurological and respiratory toxicity.. Toxicol. Ind. Health 11:33–39.
  • J.D. Sherman. (1996). Chlorpyrifos (Dursban)-associated birth defects: Report of four cases.. Arch. Environ. Health 51:5–8.
  • J.D. Sherman. (1999). Chlorpyrifos (Dursban) and Dow employees.. Environ. Health Perspect. 107:A132–134.
  • D.M. Shih, L. Gu, Y.R. Xia, M. Navab, W.F. Li, S. Hama, L.W. Castellani, C.E. Furlong, L.G. Costa, A.M. Fogelman, and A.J. Lusis. (1998). Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.. Nature 394:284–287.
  • Y. Shirasu, M. Moriya, K. Kato, A. Furuhashi, and T. Kada. (1976). Mutagenicity screening of pesticides in the microbial system.. Mutat. Res. 40:19–30.
  • B.A. Shurdut, L. Barraj, and M. Francis. (1998). Aggregate exposures under the Food Quality Protection Act: An approach using chlorpyrifos.. Regul. Toxicol. Pharmacol. 28:165–177.
  • F.R. Sidell. Clinical considerations in nerve agent intoxication, Chemical Warfare AgentsS.M. Somani. Academic Press, San Diego, (1992)155.
  • F.R. Sidell, and A. Kaminskis. (1975). Influence of age, sex, and oral contraceptives on human blood cholinesterase activity.. Clin. Chem. 21:1393–1395.
  • N.J. Simcox, R.A. Fenske, S.A. Wolz, I.C. Lee, and D.A. Kalman. (1995). Pesticides in household dust and soil: Exposure pathways for children of agricultural families.. Environ. Health Perspect. 103:1126–1134.
  • V.F. Simmon, A.D. Mitchell, and T.A. Jorgenson. (1977). Evaluation of selected pesticides and chemical mutagens. In vitro and in vivo studies.. Natl. Tech. Inform. Serv. PB 268:
  • A.K. Sinha, B.B. Gollapudi, V.A. Linscombe, and M.L. McClintock. (1989). Utilization of rat hepatocytes f or the in vitro chromosomal aberration assay.. Mutagenesis 4:147–153.
  • T.A. Slotkin, K.K. Brown, and F.J. Seidler. (2005). Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood.. Environ. Health Perspect. 113:1291–1294.
  • T.A. Slotkin, M.M. Cousins, C.A. Tate, and F.J. Seidler. (2001). Persistent cholinergic presynaptic deficits after neonatal chlorpyrifos exposure.. Brain Res. 902:229–243.
  • T.A. Slotkin, E.D. Levin, and F.J. Seidler. (2006). Comparative developmental neurotoxicity of organophosphate insecticides: Effects on brain development are separable from systemic toxicity.. Environ. Health Perspect. 114:746–751.
  • T.A. Slotkin, and F.J. Seidler. (2007). Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: Critical periods for regional and sex-selective effects.. Reprod. Toxicol. 23:421–427.
  • T.A. Slotkin, F.J. Seidler, and F. Fumagalli. (2007). Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: Similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.. Environ. Health Perspect. 115:909–916.
  • T.A. Slotkin, M.C. Southard, S.J. Adam, M.M. Cousins, and F.J. Seidler. (2004). Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos.. Brain Res. Bull. 64:227–235.
  • T.A. Slotkin, C.A. Tate, M.M. Cousins, and F.J. Seidler. (2002). Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure.. Brain Res. Dev. Brain Res. 133:163–173.
  • X. Song, F.J. Seidler, and T.A. Slotkin. (1997b). Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade.. Toxicologist 36:100.
  • X. Song, F.J. Seidler, J.L. Saleh, J. Zhang, S. Padilla, and T.A. Slotkin. (1997a). Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade.. Toxicol. Appl. Pharmacol. 145:158–174.
  • X. Song, J.D. Violin, F.J. Seidler, and T.A. Slotkin. (1998). Modeling the developmental neurotoxicity of chlorpyrifos in vitro: Macromolecule synthesis in PC12 cells.. Toxicol. Appl. Pharmacol. 151:182–191.
  • B. Sood, V. Delaney-Black, C. Covington, B. Nordstrom-Klee, J. Ager, T. Templin, J. Janisse, S. Martier, and R.J. Sokol. (2001). Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. Dose-response effect.. Pediatrics 108:E34.
  • P.S. Spencer, and H.H. Schaumburg. Central-peripheral distal axonopathy—the pathology of dying-back polyneuropathies, Progress in NeuropathologyH.M. Zimmerman. Grune and Stratton, New York, (1976)253.
  • K. Steenland, B. Jenkins, R.G. Ames, M. O'Malley, D. Chrislip, and J. Russo. (1994). Chronic neurological sequelae to organophosphate pesticide poisoning.. Am.J. Public Health 84:731–736.
  • J.C. Stevens, R.N. Hines, C. Gu, S.B. Koukouritaki, J.R. Manro, P.J. Tandler, and M.J. Zaya. (2003). Developmental expression of the major human hepatic CYP3A enzymes.. J. Pharmacol. Exp. Ther. 307:573–582.
  • T. Suehiro, T. Nakamura, M. Inoue, T. Shiinoki, Y. Ikeda, Y. Kumon, M. Shindo, H. Tanaka, and K. Hashimoto. (2000). A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression.. Atherosclerosis 150:295–298.
  • L.G. Sultatos. (1991). Metabolic activation of the organophosphorus insecticides chlorpyrifos and fenitrothion by perfused rat liver.. Toxicology 68:1–9.
  • L.G. Sultatos. (1994). Mammalian toxicology of organophosphorus pesticides.. J. Toxicol. Environ. Health 43:271–289.
  • L.G. Sultatos, M. Shao, and S.D. Murphy. (1984). The role of hepatic biotransformation in mediating the acute toxicity of the phosphorothionate insecticide chlorpyrifos.. Toxicol. Appl. Pharmacol. 73:60–68.
  • W.T. Sumerford, W.J. HayesJr., J.M. Johnston, K. Walker, and J. Spillane. (1953). Cholinesterase response and symptomatology from exposure to organic phosphorus insecticides.. AMA Arch. Ind. Hyg. Occup. Med. 7:383–398.
  • J. Tang. (2000). The neurochemical effects of repeated oral exposures to chlorpyrifos or methyl parathion on rat brain cholinergic and dopaminergic systems during early postnatal development. ix. 110 leaves
  • J. Tang, Y. Cao, R.L. Rose, A.A. Brimfield, D. Dai, J.A. Goldstein, and E. Hodgson. (2001). Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes.. Drug Metab. Dispos. 29:1201–1204.
  • J. Tang, R.L. Carr, and J.E. Chambers. (1999). Changes in rat brain cholinesterase activity and muscarinic receptor density during and after repeated oral exposure to chlorpyrifos in early postnatal development.. Toxicol. Sci. 51:265–272.
  • A.V. TerryJr., J.D. Stone, J.J. Buccafusco, D.W. Sicles, A. Sood, and M.A. Prendergast. (2003). Repeated exposures to subthreshold doses of chlorpyrifos in rats: Hippocampal damage, impaired axonal transport, and deficits in spatial learning.. J. Pharmacol. Exp. Ther. 305:375–384.
  • J.D. Thrasher, G. Heuser, and A. Broughton. (2002). Immunological abnormalities in humans chronically exposed to chlorpyrifos.. Arch. Environ. Health 57:181–187.
  • J.D. Thrasher, R. Madison, and A. Broughton. (1993). Immunologic abnormalities in humans exposed to chlorpyrifos: Preliminary observations.. Arch. Environ. Health 48:89–93.
  • Y. Tian, and T. Yamauchi. (2003). Micronucleus formation in 3-day mouse embryos associated with maternal exposure to chlorpyrifos during the early preimplantation period.. Reprod. Toxicol. 17:401–405.
  • Y. Tian, H. Ishikawa, T. Yamaguchi, T. Yamauchi, and K. Yokoyama. (2005). Teratogenicity and developmental toxicity of chlorpyrifos. Maternal exposure during organogenesis in mice.. Reprod. Toxicol. 20:267–270.
  • Y. Tian, L. Shen, Y. Gao, T. Yamauchi, X.-m. Shen, and N. Ma. (2007). Comparison of 4',6'-diamidino-2-phenylindole and Giemsa stainings in preimplantation mouse embryos micronucleus assay including a triple dose study.. Ind. Health 45:343–347.
  • C. Timchalk, A. Busby, J.A. Campbell, L.L. Needham, and D.B. Barr. (2007). Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat.. Toxicology 237:145–157.
  • C. Timchalk, A. Kousba, and T.S. Poet. (2002a). Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model.. Toxicol. Lett. 135:51–59.
  • C. Timchalk, R.J. Nolan, A.L. Mendrala, D.A. Dittenber, K.A. Brzak, and J.L. Mattsson. (2002b). A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans.. Toxicol. Sci. 66:34–53.
  • C. Timchalk, T.S. Poet, and A.A. Kousba. (2006). Age-dependent pharmacokinetic and pharmacodynamic response in preweanling rats following oral exposure to the organophosphorus insecticide chlorpyrifos.. Toxicology 220:13–25.
  • A. Vaisi-Raygani, Z. Rahimi, H. Entezami, H. Kharrazi, F. Bahrhemand, H. Tavilani, M. Rezaei, A. Kiani, B. Nomanpour, and T. Pourmotabbed. (2008). Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western Iran. Scand.J. Clin. Lab. Invest 68:123–129.
  • M. van Gemert, M. Dourson, A. Moretto, and M. Watson. (2001). Use of human data for the derivation of a reference dose for chlorpyrifos.. Regul. Toxicol. Pharmacol. 33:110–116.
  • Z. Vasilic, V. Drevenkar, V. Rumenjak, B. Stengl, and Z. Frobe. (1992). Urinary excretion of diethylphosphorus metabolites in persons poisoned by quinalphos or chlorpyrifos.. Arch. Environ. Contam. Toxicol. 22:351–357.
  • A. Venerosi, G. Calamandrei, and L. Ricceri. (2006). A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure.. Neurotoxicol. Teratol. 28:466–471.
  • R.S. Verma, and N. Srivastava. (2001). Chlorpyrifos induced alterations in levels of thiobarbituric acid reactive substances and glutathione in rat brain.. Indian J. Expos. Biol. 39:174–177.
  • R.S. Verma, and N. Srivastava. (2003). Effect of chlorpyrifos on thiobarbituric acid reactive substances, scavenging enzymes and glutathione in rat tissues.. Indian J. Biochem. Biophys. 40:423–428.
  • C.A. Vidair. (2004). Age dependence of organophosphate and carbamate neurotoxicity in the postnatal rat: Extrapolation to the human.. Toxicol. Appl. Pharmacol. 196:287–302.
  • C.J. Vidal. (2005). Expression of cholinesterases in brain and non-brain tumours.. Chem. Biol. Interact. 157–158:227–232.
  • A.M. Vinggaard, V. Breinholt, and J.C. Larsen. (1999). Screening of selected pesticides for oestrogen receptor activation in vitro.. Food Addit. Contam. 16:533–542.
  • X. Wang, B. Zuckerman, C. Pearson, G. Kaufman, C. Chen, G. Wang, T. Niu, P.H. Wise, H. Bauchner, and X. Xu. (2002). Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight.. JAMA 287:195–202.
  • S.D. Warner, C.G. Gerbig, R.J. Strebing, and J.A. Molello. Results of a two-year toxicity and oncogenicity study of chlorpyrifos administered to CD-1 mice in the diet. Dow Chemical Co., MidlandMI, (1980).
  • M.D. Waters, S. Nesnow, V.F. Simmon, A.D. Mitchell, T.A. Jorgenson, and R. Valencia. (1981). Pesticides: Mutagenic and carcinogenic potential.. Pesticide Chemist and Modern Toxicology, ACS Symposium Series No 160:89–113.
  • S.E. Wellman, and R.E. Kramer. (2004). Absence of DNA binding activity of methyl parathion and chlorpyrifos.. Toxicol. Mech. Methods 14:247–251.
  • K.D. Whitney, F.J. Seidler, and T.A. Slotkin. (1995). Developmental neurotoxicity of chlorpyrifos: Cellular mechanisms.. Toxicol. Appl. Pharmacol. 134:53–62.
  • M. Whittaker. (1986). Cholinesterase.. Monogr. Hum. Genet. 2:1.
  • M. Whittaker, A.R. Charlier, and S. Ramaswamy. (1971). Changes in plasma cholinesterase isoenzymes due to oral contraceptives.. J. Reprod. Fertil. 26:373–375.
  • R.M. Whyatt, D.B. Barr, D.E. Camann, P.L. Kinney, J.R. Barr, H.F. Andrews, L.A. Hoepner, R. Garfinkel, Y. Hazi, A. Reyes, J. Ramirez, Y. Cosme, and F.P. Perera. (2003b). Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns.. Environ. Health Perspect. 111:749–756.
  • R.M. Whyatt, D.E. Camann, P.L. Kinney, A. Reyes, J. Ramirez, J. Dietrich, D. Diaz, D. Holmes, and F.P. Perera. (2002). Residential pesticide use during pregnancy among a cohort of urban minority women.. Environ. Health Perspect. 110:507–514.
  • R.M. Whyatt, D. Camann, F.P. Perera, V.A. Rauh, D. Tang, P.L. Kinney, R. Garfinkel, H. Andrews, L. Hoepner, and D.B. Barr. (2005). Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth.. Toxicol. Appl. Pharmacol. 206:246–254.
  • R.M. Whyatt, R. Garfinkel, L.A. Hoepner, D. Holmes, M. Borjas, M.K. Williams, A. Reyes, V. Rauh, F.P. Perera, and D.E. Camann. (2007). Within-and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City.. Environ. Health Perspect. 115:383–389.
  • R.M. Whyatt, V.A. Rauh, D. Camann, D. Tang, P.L. Kinney, R. Garfinkel, H. Andrews, L. Hoepner, and F.P. Perera. (2004b). Residential pesticide exposure, fetal growth and neurocognitive development among urban minorities.. Neurotoxicology (Amsterdam) 25:683.
  • R.M. Whyatt, V. Rauh, D.B. Barr, D.E. Camann, H.F. Andrews, R. Garfinkel, L.A. Hoepner, D. Diaz, J. Dietrich, A. Reyes, D. Tang, P.L. Kinney, and F.P. Perera. (2004a). Prenatal insecticide exposures and birth weight and length among an urban minority cohort.. Environ. Health Perspect. 112:1125–1132.
  • R. Whyatt, V. Rauh, D. Barr, D. Camann, H. Andrews, and F. Perera. (2003a). Prenatal insecticide exposure adversely affects fetal growth in an urban minority cohort.. Am.J. Epidemiol. 157:S68.
  • B. Wielgomas, and J. Krechniak. (2007). Effect of alpha-cypermethrin and chlorpyrifos in a 28-day study on free radical parameters and cholinesterase activity in Wistar rats.. Polish J. Environ. Stud. 16:91–95.
  • G.M. Williams. (1977). Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.. Cancer Res 37:1845–1851.
  • G.M. Williams, E. Bermudez, and D. Scaramuzzino. (1977a). Rat hepatocyte primary cultures III. Improved dissociation and attachment techniques and the enhancement of survival by culture medium.. In Vitro 13:809–817.
  • R.T. Williams, P. Millburn, and R.L. Smith. (1965). The influence of enterohepatic circulation on toxicity of drugs.. Ann. NY Acad. Sci. 123:110–124.
  • N.K. Wilson, J.C. Chuang, and C. Lyu. (2001). Levels of persistent organic pollutants in several child day care centers.. J. Expos. Anal. Environ. Epidemiol. 11:449–458.
  • N.K. Wilson, J.C. Chuang, R. Iachan, C. Lyu, S.M. Gordon, M.K. Morgan, H. Ozkaynak, and L.S. Sheldon. (2004). Design and sampling methodology for a large study of preschool children's aggregate exposures to persistent organic pollutants in their everyday environments.. J. Expos. Anal. Environ. Epidemiol. 14:260–274.
  • N.K. Wilson, J.C. Chuang, C. Lyu, R. Menton, and M.K. Morgan. (2003). Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home.. J. Expos. Anal. Environ. Epidemiol. 13:187–202.
  • G.C. Windham, L. Fenster, B. Hopkins, and S.H. Swan. (1995). The association of moderate maternal and paternal alcohol consumption with birthweight and gestational age.. Epidemiology 6:591–597.
  • M.S. Wolff, S. Engel, G. Berkowitz, S. Teitelbaum, J. Siskind, D.B. Barr, and J. Wetmur. (2007). Prenatal pesticide and PCB exposures and birth outcomes.. Pediatr. Res. 61:243–250.
  • Y.K. Won, J. Liu, K. OlivierJr., Q. Zheng, and C.N. Pope. (2001). Age-related effects of chlorpyrifos on acetylcholine release in rat brain.. Neurotoxicology 22:39–48.
  • Y.J. Wu, P. Harp, X.R. Yan, and C.N. Pope. (2003). Nicotinic autoreceptor function in rat brain during maturation and aging: Possible differential sensitivity to organophosphorus anticholinesterases.. Chem. Biol. Interact. 142:255–268.
  • H.H. Xu, and K.M. Schurr. (1990). Genotoxicity of 22 pesticides in mictrotitration SOS chromotest.. Toxicity Assess. 5:1–14.
  • Y. Yamada, T. Takatori, M. Nagao, H. Iwase, N. Kuroda, J. Yanagida, and T. Shinozuka. (2001). Expression of paraoxonase isoform did not confer protection from acute sarin poisoning in the Tokyo subway terrorist attack.. Int.J. Legal Med. 115:82–84.
  • D. Yang, A. Howard, D. Bruun, M. Ajua-Alemanj, C. Pickart, and P.J. Lein. (2008). Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase.. Toxicol. Appl. Pharmacol. 228:32–41.
  • B.L. Yano, J.T. Young, and J.L. Mattsson. (2000). Lack of carcinogenicity of chlorpyrifos insecticide in a high-dose, 2-year dietary toxicity study in Fischer 344 rats.. Toxicol. Sci. 53:135–144.
  • R.A. Yeary, J. Eaton, E. Gilmore, B. North, and J. Singell. (1993). A multiyear study of blood cholinesterase activity in urban pesticide applicators.. J. Toxicol. Environ. Health 39:11–25.
  • K. Yokoyama, A. Yamada, and N. Mimura. (1996). Clinical profiles of patients with sarin poisoning after the Tokyo subway attack.. Am.J. Med. 100:586.
  • J.G. Young, B. Eskenazi, E.A. Gladstone, A. Bradman, L. Pedersen, C. Johnson, D.B. Barr, C.E. Furlong, and N.T. Holland. (2005). Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates.. Neurotoxicology 26:199–209.
  • K.L. Yuknavage, R.A. Fenske, D.A. Kalman, M.C. Keifer, and C.E. Furlong. (1997). Simulated dermal contamination with capillary samples and field cholinesterase biomonitoring.. J. Toxicol. Environ. Health 51:35–55.
  • V.G. Zartarian, H. Ozkaynak, J.M. Burke, M.J. Zufall, M.L. Rigas, and E.J. FurtawJr.. (2000). A modeling framework for estimating children's residential exposure and dose to chlorpyrifos via dermal residue contact and nondietary ingestion.. Environ. Health Perspect. 108:505–514.
  • H. Zhang, J. Liu, and C.N. Pope. (2002). Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex.. Arch. Toxicol. 75:676–684.
  • Q. Zhao, M. Dourson, and B. Gadagbui. (2006). A review of the reference dose for chlorpyrifos.. Regul. Toxicol. Pharmacol. 44:111–124.
  • Q. Zhao, B. Gadagbui, and M. Dourson. (2005). Lower birth weight as a critical effect of chlorpyrifos: A comparison of human and animal data.. Regul. Toxicol. Pharmacol. 42:55–63.
  • Q. Zheng, K. Olivier, Y.K. Won, and C.N. Pope. (2000). Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats.. Toxicol. Sci. 55:124–132.

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