Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects

References

• Abdullah, M., and Wheeler, E. F. (1985). Seasonal variations, and the intra-household distribution of food in a Bangladeshi village. Am. J. Clin. Nutr. 41:1305–1313.
   PubMed Web of Science ®Google Scholar
• Ahmad, S. A., Sayed, M. H. S. U., Barua, S., Khan, M. H., Faruquee, M. H., Jalil, A., Hadi, S. A., and Talukder, H. K. (2001). Arsenic in drinking water and pregnancy outcomes. Environ. Health Perspect. 109(6):629–631.
   PubMed Web of Science ®Google Scholar
• Ahsan, H., Chen, Y., Wang, Q., Slavkovich, V., Graziano, J. H., and Santella, R. M. (2003). DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis. Toxicol. Lett. 143:123–131.
   PubMed Web of Science ®Google Scholar
• Ahsan, H., Chen, Y., Parvez, F., Zablotska, L., Argos, M., Hussain, I., Momotaj, H., Levy, D., Chen, Z., Slavkovich, V., van Geen, A., Howe, G. R., and Graziano, J. H. (2006a). Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am. J. Epidemiol. 163(12):1138–1148.
   PubMed Web of Science ®Google Scholar
• Ahsan, H., Chen, Y., Parvez, F., Argos, M., Hussain, A., Momotaj, H., Levy, D., van Geen, A., Howe, G., and Graziano, J. H. (2006b). Health Effects of Arsenic Longitudinal Study (HEALS): Description of a multidisciplinary epidemiologic investigation. J. Expo. Sci. Envion. Epidemiol. 16:191–205.
   PubMed Web of Science ®Google Scholar
• Ahsan, H., Chen, Y., Kibriya, M. G., Slavkovich, V., Parvez, F., Jasmine, F., Gamble, M. V., and Graziano, J. H. (2007). Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol. Biomarkers Prev. 16(6):1270–1278.
   PubMed Web of Science ®Google Scholar
• Alain, G., Tousignant, J., and Rozenfarb, E. (1993). Chronic arsenic toxicity. Int. J. Dermatol. 32:899–901.
   PubMed Web of Science ®Google Scholar
• An, Y., Gao, Z., Wang, Z., Yang, S., Liang, J., Feng, Y., Kato, K., Nakano, M., Okada, S., and Yamanaka, K. (2004). Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China. Cancer Lett. 214(1):11–18.
   PubMed Web of Science ®Google Scholar
• Andrew, A. S., Karagas, M. R., and Hamilton, J. W. (2003). Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int. J. Cancer 104:263–268.
   PubMed Web of Science ®Google Scholar
• Andrew, A. S., Burgess, J. L., Meza, M. M., Demidenko, E., Waugh, M. G., Hamilton, J. W., and Karagas, M. R. (2006). Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ. Health Perspect. 114(8):1193–1198.
   PubMed Web of Science ®Google Scholar
• Arnold, L. L., Eldan, M., van Gemert, M., Capen, C. C., and Cohen, S. M. (2003). Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice. Toxicology 190:197–219.
   PubMed Web of Science ®Google Scholar
• Arnold, L. L., Eldan, M., Nyska, A., van Gemert, M., and Cohen, S. M. (2006). Dimethylarsinic acid: Results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice. Toxicology 223:82–100.
   PubMed Web of Science ®Google Scholar
• ATSDR (Agency for Toxic Substances and Disease Registry). (2005). Toxicological profile for arsenic. Draft for public comment. Update. US Department of Health and Human Services, Public Health Service.
   Google Scholar
• Ayotte, J. D., Baris, D., Cantor, K. P., Colt, J., Robinson Jr., G. R., Lubin, J. H., Karagas, M., Hoover, R. N., Fraumeni Jr., J. F., and Silverman, D. T. (2006). Bladder cancer mortality and private well use in New England: An ecological study. J. Epidemiol. Community Health 60:168–172.
   PubMed Web of Science ®Google Scholar
• Banerjee, M., Sarkar, J., Das, J. K., Mukherjee, A., Sarkar, A. K., Mondal, L., and Giri, A. K. (2007). Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis 28(3):672–676.
   PubMed Web of Science ®Google Scholar
• Basu, A., Mahata, J., Roy, A. K., Sarkar, J. N., Poddar, G., Nandy, A. K., Sarkar, P. K., Dutta, P. K., Banerjee, A., Das, M., Ray, K., RoyChoudhury, S., Natarajan, A. T., Nilsson, R., and Giri, A. K. (2002). Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal, India. Mut. Res. 516(1–2):29–40.
   Google Scholar
• Bates, M. N., Smith, A. H., and Cantor, K. P. (1995). Case–control study of bladder cancer and arsenic in drinking water. Am. J. Epidemiol. 141:523–530.
   PubMed Web of Science ®Google Scholar
• Bates, M. N., Rey, O. A., Biggs, M. L., Hopenhayn, C., Moore, L. E., Kalman, D., Steinmaus, C., and Smith, A. H. (2004). Case–control study of bladder cancer and exposure to arsenic in Argentinia. Am. J. Epidemiol. 159:381–389.
   PubMed Web of Science ®Google Scholar
• Beane Freeman, L. E., Dennis, L. K., Lynch, C. F., Thorne, P. S., and Just, C. L. (2004). Toenail arsenic content and cutaneous melanoma in Iowa. Am. J. Epidemiol. 160:679–687.
   PubMed Web of Science ®Google Scholar
• Benbrahim-Tallaa, L., and Waalkes, M. P. (2008). Inorganic arsenic and human prostate cancer. Environ. Health Perspect. 116(2):158–164
   PubMed Web of Science ®Google Scholar
• Biswas, S., Talukder, G., and Sharma, A. (1999). Prevention of cytotoxic effects of arsenic by short-term dietary supplementation with selenium in mice in vivo. Mut. Res. 441:155–160.
   Google Scholar
• Borak, J., and Hosgood, H.D. (2007). Seafood arsenic: Implications for human risk assessment. Regul. Toxicol. Pharmacol. 47:204–212.
   PubMed Web of Science ®Google Scholar
• Bredfeldt, T. G., Jagadish, B., Eblin, K. E., Mash, E. A., and Gandolfi, A. J. (2006). Monomethylarsonous acid induces transformation of human bladder cells. Toxicol. Appl. Pharmacol. 216(1):69–79.
   PubMed Web of Science ®Google Scholar
• Brima, E. I., Jenkins, R. O., Lythgoe, P. R., Gault, A. G., Polya, D. A., and Haris, P. I. (2007). Effect of fasting on the pattern of urinary arsenic excretion. J Environ Monit 9(1):98–103.
   PubMedGoogle Scholar
• Brown, K. G. (2007). How creditable are cancer risk estimates from the S.W. Taiwan database for arsenic in drinking water? HERA 13:180–190.
   Google Scholar
• Brown, K. G., and Ross, G. L. (2002). Arsenic, drinking water, and health: A position paper of the American Council on Science and Health. Regul. Toxicol. Pharmacol. 36:162–174.
   PubMed Web of Science ®Google Scholar
• Buchet, J. P., Lauwerys, R., and Roels, H. (1981a). Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. Int Arch Occup Environ Health 48(1):71–80.
   Web of Science ®Google Scholar
• Buchet, J. P., Lauwerys, R., and Roels, H. (1981b). Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers. Int Arch Occup Environ Health 48(2):111–118.
   Web of Science ®Google Scholar
• Cantor, K. P., and Lubin, J. H. (2007). Arsenic, internal cancers, and issues in inference from studies of low-level exposures in human populations. Toxicol. Appl. Pharmacol. 222:252–257.
   Web of Science ®Google Scholar
• Chanda, S., Dasgupta, U. B., Guha Mazumder, D., Gupta, M., Chaudhuri, U., Lahiri, S., Das, S., Ghosh, N., and Chatterjee, D. (2006). DNA hypermethylation of promoter of gene p53 and p16 in arsenic-exposed people with and without malignancy. Toxicol Sci 89(2):431–437.
   Google Scholar
• Chen, C.-J., Chuang, Y.-C., Lin, T.-M., and Wu, H.-Y. (1985). Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high arsenic artesian well water and cancers. Cancer Res 45:5895–5899.
   Google Scholar
• Chen, C.-J., Chiou, H.-Y., Chiang, M.-H., Lin, L.-J., and Tai, T.-Y. (1996). Dose–response relationship between ischemic heart disease mortality and long-term arsenic exposure. Arterioscler Thromb Vasc Biol 16:504–510.
   Google Scholar
• Chen, C. L., Hsu, L. I., Chiou, H. Y., Hsueh, Y. M., Chen, S. Y., Wu, M. M., and Chen, C. J. (2004). Ingested arsenic, cigarette smoking, and lung cancer risk: A follow-up study in arseniasis-endemic areas in Taiwan. JAMA 292:2984–2990.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Graziano, J. H., Parvez, F., Hussain, I., Momotaj, H., van Geen, A., Howe, G. R., and Ahsan, H. (2006). Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh. Epidemiology 17:459–467.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Factor-Litvak, P., Howe, G. R., Graziano, J. H., Brandt-Rauf, P., Parvez, F., van Geen, A., and Ahsan, H. (2007a). Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: A population-based, cross-sectional study. Am. J. Epidemiol. 165(5):541–552.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Hall, M., Graziano, J. H., Slavkovich, V., van Geen, A., Parvez, F., and Ahsan, H. (2007b). A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions. Cancer Epidemiol. Biomarkers Prev. 16:207–213.
   Google Scholar
• Chen, Y. C., Guo, Y. L., Su, H. J., Hsueh, Y. M., Smith, T. J., Ryan, L. M., Lee, M. S., Chao, S. C., Lee, J. Y., and Christiani, D. C. (2003a). Arsenic methylation and skin cancer risk in southwestern Taiwan. J. Occup. Environ. Med. 45(3):241–248.
   PubMed Web of Science ®Google Scholar
• Chen, Y. C., Su, H. J., Guo, Y. L., Hsueh, Y. M., Smith, T. J., Ryan, L. M., Lee, M. S., and Christiani, D. C. (2003b). Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes Control 14(4):303–310.
   Google Scholar
• Chiou, H.-Y., Hsueh, Y.-M., Hsieh, L.-L., Hsu, L.-I., Hsu, Y.-H., Hsieh, F.-I., Wei, M.-L., Chen, H.-C., Yang, H.-T., Leu, L.-C., Chu, T.-H., Chen-Wu, C., Yang, M.-H., and Chen, C.-J. (1997a). Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mut. Res. 386(3):197–207.
   Google Scholar
• Chiou, H.-Y., Huang, W.-I., Su, C.-L., Chang, S.-F., Hsu, Y.-H., and Chen, C. J. (1997b). Dose–response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 28:1717–1723.
   PubMed Web of Science ®Google Scholar
• Chiou, H. Y., Chiou, S. T., Hsu, Y. H., Chou, Y. L., Tseng, C. H., Wie, M. L., and Chen, C. J. (2001). Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan. Am. J. Epidemiol. 153:411–418.
   PubMed Web of Science ®Google Scholar
• Chiu, H. F., Ho, S. C., Wang, L. Y., Wu, T. N., and Yang, C. Y. (2004). Does arsenic exposure increase the risk for liver cancer? J. Toxicol. Environ. Health A 67(19):1491–1500.
   Google Scholar
• Council of the European Union (1998). Council Directive 98/83/EC of November1998 on the quality of water intended for human consumption.
   Google Scholar
• Cohen, S. M., Arnold, L. L., Eldan, M., Lewis, A. S., and Beck, B. D. (2006). Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol. 36(2):99–133.
   PubMed Web of Science ®Google Scholar
• Danaee, H., Nelson, H. H., Liber, H., Little, J. B., and Kelsey, K. T. (2004). Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells. Mutagenesis 19(2):143–148.
   PubMed Web of Science ®Google Scholar
• Deknudt, G., Léonard, A., Arany, J., Jenar-Du Buisson, G., and Delavignette, E. (1986). In vivo studies in male mice on the mutagenic effects of inorganic arsenic. Mutagenesis 1:33–34.
   PubMed Web of Science ®Google Scholar
• Dieter, H. H.(1991). Occurrence and toxicology of arsenic and its significance for human health in drinking water [in German]. In: Die Trinkwasserverordnung. Einführung und Erläuterungen für Wasserversorgungsunternehmen und Überwachungsbehörden, Aurand, K. et al., eds pp. 154–171. Erich Schmidt Verlag, Berlin.
   Google Scholar
• Dopp, E., Hartmann, L. M., Florea, A.-M., von Recklinghausen, U., Pieper, R., Shokouhi, B., Rettenmeier, A. W., Hirner, A. V., and Obe, G. (2004). Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells. Toxicol. Appl. Pharmacol. 201:156–165.
   PubMed Web of Science ®Google Scholar
• Dopp, E., Hartmann, L. M., von Recklinghausen, U., Florea, A. M., Rabieh, S., Zimmermann, U., Shokouhi, B., Yadav, S., Hirner, A. V., and Rettenmeier, A. W. (2005). Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-/genotoxicity in fibroblasts and hepatoma cells. Toxicol. Sci. 87(1):46–56.
   PubMed Web of Science ®Google Scholar
• Dulout, F. N., Grillo, C. A., Seoane, A. I., Maderna, C. R., Nilsson, R., Vahter, M., Darroudi, F., and Natarajan, A. T. (1996). Chromosomal aberrations in peripheral blood lymphocytes from native Andean women and children from Northwestern Argentina exposed to arsenic in drinking water. Mut. Res. 370(3,4):151–158.
   PubMedGoogle Scholar
• Eastmond, D. A., and Tucker, J. D. (1989). Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ. Mol. Mutagen. 13:34–43.
   PubMed Web of Science ®Google Scholar
• Eblin, K. E., Bowen, M. E., Cromey, D. W., Bredfeldt, T. G., Mash, E. A., Lau, S. S., and Gandolfi, A. J. (2006). Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture. Toxicol. Appl. Pharmacol. 217(1):7–14.
   PubMed Web of Science ®Google Scholar
• Environmental Protection Agency. (1981). Community health associated with arsenic in drinking water in Millard County, Utah. Environmental Protection Agency, Cincinnati, OH.
   Google Scholar
• Environmental Protection Agency. (2001). National primary drinking water regulations, arsenic and clarifications to compliance and new source contaminants monitoring, final rule. Federal Register 66:6976–7066.
   Google Scholar
• Environmental Protection Agency. (2005). Toxicological review of ingested inorganic arsenic. Draft. US Environmental Protection Agency, Washington, DC.
   Google Scholar
• Environmental Protection Agency. (2007). Integrated Risk Information system (IRIS). Available at: http:/www.epa.gov./iris [Accessed: January 2007.]
   Google Scholar
• European Chemicals Bureau (2007). European chemical substances information system (ESIS). Available at: http://ecb.jrc.it/esis [Accessed August 2007.]
   Google Scholar
• Exponent. (2005). Epidemiologic studies of low-level arsenic exposure in drinking water and bladder cancer: A review and meta-analysis. Doc. no. BE02909.001 0201 0805 PM25. Exponent, Washington, DC.
   Google Scholar
• Ferreccio, C., Gonzalez, C., Milosavljevic, V., Marshall, G., Sancha, A. M., and Smith, A. H. (2000). Lung cancer and arsenic concentrations in drinking water in Chile. Epidemiology 11:673–679.
   PubMed Web of Science ®Google Scholar
• Federal Republic of Germany. (1991). Ordinance from December 12 1990 on drinking water and water for food production enterprises [in German]. BGBl I: 2613.
   Google Scholar
• Florea, A.-M., Yamoah, E.N., and Dopp, E. (2005). Intracellular calcium disturbances induced by arsenic and its methylated derivatives in relation to genomic damage and apoptosis induction. Environ. Health Perspect. 113(6):659–664.
   PubMed Web of Science ®Google Scholar
• Frost, F., Craun, C., and Brown, K. G. (2002). Detection of excess arsenic-related cancer risk. Environ. Health Perspect. 110:A12–A13.
   Web of Science ®Google Scholar
• Gamble, M. V., Liu, X., Ahsan, H., Pilsner, J. R., Ilievski, V., Slavkovich, V., Parvez, F., Levy, D., Factor-Litvak, P., and Graziano, J. H. (2005). Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ. Health Perspect. 113:1683–1688.
   PubMed Web of Science ®Google Scholar
• Gamble, M. V., Liu, X., Ahsan, H., Pilsner, J. R., Ilievski, V., Slavkovich, V., Parvez, F., Chen, Y., Levy, D., Factor-Litvak, P., and Graziano, J. H. (2006). Folate and arsenic metabolism: A double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am. J. Clin. Nutr. 84:1093–1101.
   PubMed Web of Science ®Google Scholar
• Gebel, T. (1998). Suppression of arsenic-induced chromosome mutagenicity by antimony. Mut Res. 412:213–218.
   PubMed Web of Science ®Google Scholar
• Gebel, T. W. (2001). Genotoxicity of arsenical compounds. Int. J. Hyg. Environ. Health 203:249–262.
   PubMed Web of Science ®Google Scholar
• Gebel, T., Christensen, S., and Dunkelberg, H. (1997). Comparative and environmental genotoxicity of antimony and arsenic. Anticancer Res. 17:2603–2607.
   PubMed Web of Science ®Google Scholar
• Gentry, P. R., Covington, T. R., Mann, S., Shipp, A. M., Yager, J. W., and Clewell, H. J. (2004). Physiologically based pharmacokinetic modeling of arsenic in the mouse. J. Toxicol. Environ. Health A 67(1):43–71.
   PubMed Web of Science ®Google Scholar
• Ghosh, P., Basu, A., Mahata, J., Basu, S., Sengupta, M., Das, J. K., Mukherjee, A., Sarkar, A. K., Mondal, L., Ray, K., and Giri, A. K. (2006). Cytogenetic damage and genetic variants in the individuals susceptible to arsenic-induced cancer through drinking water. Int. J. Cancer 118(10):2470–2478.
   PubMed Web of Science ®Google Scholar
• Gómez, S. E., del Razo, L. M., and Munoz Sanchez, J. L. (2005). Induction of DNA damage by free radicals generated either by organic or inorganic arsenic (AsIII, MMAIII, and DMAIII) in cultures of B and T lymphocytes. Biol. Trace Elem. Res. 108(1–3):115–126.
   PubMed Web of Science ®Google Scholar
• Gonsebatt, M. E., Vega, L., Salazar, A. M., Montero, R., Guzman, P., Blas, J., Del Razo, L. M., Garcia-Vargas, G., Albores, A., Cebrian, M. E., Kelsh, M., and Ostrosky-Wegman, P. (1997). Cytogenetic effects in human exposure to arsenic. Mut. Res. 386(3):219–228.
   Google Scholar
• Grobe, J. W. (1977). Gutachterliche und therapeutische Befunde und Beobachtungen bei Moselwinzern mit Arsenintoxikationsspätfolgeschädigung. Berufsdermatosen 25(3):124–130.
   PubMedGoogle Scholar
• Grobe, J. W. (1982). Dupuytren'sche Kontrakturen bei Moselwinzern mit Arsenspätfolgeschädigung. Derm Beruf Umwelt 30(6):196–198.
   PubMedGoogle Scholar
• Guha Mazumder, D. N., Haque, R., Ghosh, N., De, B. K., Santra, A., Chakraborty, D., and Smith, A. H. (1998). Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal, India. Int. J. Epidemiol. 27:871–877.
   PubMed Web of Science ®Google Scholar
• Guo, H. R. (2004). Arsenic level in drinking water and mortality of lung cancer (Taiwan). Cancer Causes Control 15:171–177.
   PubMed Web of Science ®Google Scholar
• Guo, X., Liu, Z., Huang, C., and You, L. (2006). Levels of arsenic in drinking-water and cutaneous lesions in Inner Mongolia. J. Health Popul. Nutr. 24:214–220.
   PubMed Web of Science ®Google Scholar
• Hall, M., Chen, Y., Ahsan, H., Slavkovich, V., van Geen, A., Parvez, F., and Graziano, J. (2006). Blood arsenic as a biomarker of arsenic exposure: results from a prospective study. Toxicology 225(2–3):225–233.
   PubMed Web of Science ®Google Scholar
• Haque, R., Mazumder, D. N., Samanta, S., Ghosh, N., Kalman, D., Smith, M. M., Mitra, S., Santra, A., Lahiri, S., Das, S., De, B. K., and Smith, A. H. (2003). Arsenic in drinking water and skin lesions: Dose–response data from West Bengal, India. Epidemiology 14(2):174–182.
   PubMed Web of Science ®Google Scholar
• Harrington-Brock, K., Cabrera, M., Collard, D. D., Doerr, C. L., McConnell, R., Moore, M. M., Sandoval, H., and Fuscoe, J. C. (1999). Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: A pilot study. Mut. Res. 431:247–257.
   Google Scholar
• Hartwig, A., Groblinghoff, U. D., Beyersmann, D., Natarajan, A. T., Filon, R., and Mullenders, L. H. (1997). Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts. Carcinogenesis 18:399–405.
   PubMed Web of Science ®Google Scholar
• Hartwig, A., Pelzer, A., Asmuss, M., and Bürkle, A. (2003). Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int. J. Cancer 104:1–6.
   PubMed Web of Science ®Google Scholar
• Hassauer, M., and Kalberlah, F. (1999). Arsen und Verbindungen. In: Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch toxikologischer Basisdaten und ihre Bewertung, Kennziffer D 095.Eikmann, T., Heinrich, U., Heinzow, B., Konietzka, R.eds. Erich Schmidt Verlag, Berlin.
   Google Scholar
• Hayakawa, T., Kobayashi, Y., Cui, X., and Hirano, S. (2005). A new metabolic pathway of arsenite: Arsenic–glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arch. Toxicol. 79(4):183–191.
   Web of Science ®Google Scholar
• He, X.-Q., Chen, R., Yang, P., Li, A.-P., Zhou, J.-W., and Liu, Q.-Z. (2007). Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells. Toxicol. Appl. Pharmacol. 220(1):18–24.
   PubMed Web of Science ®Google Scholar
• Hopenhayn, C., Ferreccio, C., Browning, S. R., Huang, B., Peralta, C., Gibb, H., and Hertz-Picciotto, I. (2003). Arsenic exposure from drinking water and birth weight. Epidemiology 14(5):593–602.
   PubMed Web of Science ®Google Scholar
• Hopenhayn-Rich, C., Biggs, M. L., Kalman, D. A., Moore, L. E., and Smith, A. H. (1996). Arsenic methylation patterns before and after changing from high to lower concentrations of arsenic in drinking water. Environ. Health Perspect. 104(11):1200–1207.
   PubMed Web of Science ®Google Scholar
• Hsueh, Y. M., Chiou, H. Y., Huang, Y. L., Wu, W. L., Huang, C. C., Yang, M. H., Lue, L. C., Chen, G. S., and Chen, C. J. (1997). Serum beta-carotene level, arsenic methylation capability and incidence of arsenic-induced skin cancer. Cancer Epidemiol. Biomarkers Prev. 6:589–596.
   PubMed Web of Science ®Google Scholar
• Huang, Y.-K., Tseng, C.-H., Huang, Y.-L., Yang, M.-H., Chen, C.-J., and Hsueh, Y.-M. (2007). Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. Toxicol. Appl. Pharmacol. 218(2):135–142.
   PubMed Web of Science ®Google Scholar
• Hughes, M. F. (2006). Biomarkers of exposure: A case study with inorganic arsenic. Environ. Health Perspect. 114: 1790–1796.
   PubMed Web of Science ®Google Scholar
• International Agency for Research on Cancer. (2004). IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 84. Some drinking-water disinfectants and contaminants, including arsenic. WHO, World Health Organization, Geneva.
   Google Scholar
• Kapaj, S., Peterson, H., Liber, K., and Bhattacharya, P. (2006). Human health effects from chronic arsenic poisoning—A review. J. Environ. Sci. Health A 41(10):2399–2428.
   Google Scholar
• Karagas, M. R., Tosteson, T. D., Blum, J., Klaue, B., Weiss, J. E., Stannard, V., Spate, V., and Morris, J. S. (2000). Measurement of low levels of arsenic exposure: A comparison of water and toenail concentrations. Am. J. Epidemiol. 152:84–90.
   PubMed Web of Science ®Google Scholar
• Karagas, M. R., Stukel, T. A., Morris, J. S., Tosteson, T. D., Weiss, J. E., Spencer, S. K., and Greenberg, E. R. (2001a). Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case–control study. Am. J. Epidemiol. 153:559–565.
   PubMed Web of Science ®Google Scholar
• Karagas, M. R., Le, C. X., Morris, S., Blum, J., Lu, X., Spate, V., Carey, M., Stannard, V., Klaue, B., and Tosteson, T. D. (2001b). Markers of low level arsenic exposure for evaluating human cancer risks in a US population. Int. J. Occup. Med. Environ. Health 14:171–175.
   PubMedGoogle Scholar
• Karagas, M. R., Stukel, T. A., and Tosteson, T. D. (2002). Assessment of cancer risk and environmental levels of arsenic in New Hampshire. Int. J. Hyg. Environ. Health 205:85–94.
   PubMed Web of Science ®Google Scholar
• Karagas, M. R., Tosteson, T. D., Morris, J. S., Demidenko, E., Mott, L. A., Heaney, J., and Schned, A. (2004). Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes Control 15:465–472.
   PubMed Web of Science ®Google Scholar
• Kashiwada, E., Kuroda, K., and Endo, G. (1998). Aneuploidy induced by dimethylarsinic acid in mouse bone marrow cells. Mut. Res. 413:33–38.
   Google Scholar
• Kile, M. L., Houseman, E. A., Breton, C. V., Smith, T., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., and Christiani, D. C. (2007). Dietary arsenic exposure in Bangladesh. Environ. Health Perspect. 115(6):889–893.
   PubMed Web of Science ®Google Scholar
• Kitchin, K. T., and Wallace, K. (2008). The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J. Inorg. Bioch. 102(3):532–539.
   PubMed Web of Science ®Google Scholar
• Kligerman, A. D., Doerr, C. L., Tennant, A. H., Harrington-Brock, K., Allen, J. W., Winkfield, E., Poorman-Allen, P., Kundu, B., Funasaka, K., Roop, B. C., Mass, M. J., and DeMarini, D. M. (2003). Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations. Environ. Mol. Mutagen. 42:192–205.
   PubMed Web of Science ®Google Scholar
• Knobeloch, L. M., Zierold, K. M., and Anderson, H. A. (2006). Association of arsenic-contaminated drinking-water with prevalence of skin cancer in Wisconsin's Fox River Valley. J. Health Popul. Nutr. 24:206–213.
   PubMed Web of Science ®Google Scholar
• Krishnamohan, M., Seawright, A. A., and Ng, J. C. (2006). Monomethylarsonous acid (MMAIII) is carcinogenic in mice. Abstract number 2086. Toxicologist 90:427.
   Google Scholar
• Kumagai, Y., and Sumi, D. (2007). Arsenic: Signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity. Annu. Rev. Pharmacol. Toxicol. 47:243–262.
   PubMed Web of Science ®Google Scholar
• Lai, M. S., Hsueh, Y. M., Chen, C. J., Shyu, M. P., Kuo, T. L., Wu, M. M., and Tai, T. Y. (1994). Ingested inorganic arsenic and prevalence of diabetes mellitus. Am. J. Epidemiol. 139:484–492.
   PubMed Web of Science ®Google Scholar
• Lamm, S. H., Byrd, D. M., Kruse, M. B., Feinleib, M., and Lai, S. H. (2003). Bladder cancer and arsenic exposure: Differences in the two populations enrolled in a study in southwest Taiwan. Biomed. Environ. Sci. 16(4):355–368.
   PubMed Web of Science ®Google Scholar
• Lamm, S. H., Engel, A., Kruse, M. B., Feinleib, M., Byrd, D. M., Lai, S., and Wilson, R. (2004). Arsenic in drinking water and bladder cancer mortality in the United States: An analysis based on 133 US counties and 30 years of observation. J. Occup. Environ. Med. 46:298–306.
   PubMed Web of Science ®Google Scholar
• Lamm, S. H., Engel, A., Penn, C. A., Chen, R., and Feinleib, M. (2006). Arsenic cancer risk confounder in Southwest Taiwan data set. Environ. Health Perspect. 114(7):1077–1082.
   PubMed Web of Science ®Google Scholar
• Lamm, S. H., Luo, Z.-D., Bo, F.-B., Zhang, G.-Y., Zhang, Y.-M., Wilson, R., Byrd, D. M., Lai, S., Li, F.-X., Polkanov, M., Tong, Y., Loo, L., Tucker, S. B. and the Inner Mongolia Cooperative Arsenic Project (2007). An epidemiologic study of arsenic-related skin disorders and skin cancer and the consumption of arsenic-contaminated well waters in Huhhot, Inner Mongolia, China. HERA 13(4):713–746.
   Google Scholar
• Le, X. C., Lu, X., Ma, M., Cullen, W. R., Aposhian, H. V., and Zheng, B. (2000). Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 72(21):5172–5177.
   Web of Science ®Google Scholar
• Lee, T.-C., Oshimura, M., and Barrett, J. C. (1985). Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6:1421–1426.
   PubMed Web of Science ®Google Scholar
• Lerda, D. (1994). Sister-chromatid exchange (SCE) among individuals chronically exposed to arsenic in drinking water. Mut. Res. 312:111–120.
   Google Scholar
• Lewinska, D., Palus, J., Stepnik, M., Dziubaltowska, E., Beck, J., Rydzynski, K., Natarajan, A. T., and Nilsson, R. (2007). Micronucleus frequency in peripheral blood lymphocytes and buccal mucosa cells of copper smelter workers, with special regard to arsenic exposure. Int Arch Occup Environ Health 80(5):371–380.
   PubMed Web of Science ®Google Scholar
• Lewis, D. R., Southwick, J. W., Ouellet-Hellstrom, R., Rench, J., and Calderon, R. L. (1999). Drinking water arsenic in Utah: A cohort mortality study. Environ. Health Perspect. 107:359–365.
   PubMed Web of Science ®Google Scholar
• Li, J. H., and Rossman, T. G. (1989). Mechanisms of comutagenesis of sodium arsenite with N-methyl-N-nitrosurea. Biol. Trace. Elem. Res. 21:373–381.
   PubMed Web of Science ®Google Scholar
• Li, X. S., Zhi, J. L., and Gao, R. O. (1995) Effect of fluoride exposure on intelligence in children. Fluoride 28(4):189–192.
   Web of Science ®Google Scholar
• Lindberg, A.-L., Kumar, R., Goessler, W., Thirumaran, R., Gurzau, E., Koppova, K., Rudnai, P., Leonardi, G., Fletcher, T., and Vahter, M. (2007). Metabolism of low dose inorganic arsenic in a Central European population—Influence of gender and genetic polymorphisms. Environ. Health Perspect. 115(7):1081–1086.
   PubMed Web of Science ®Google Scholar
• Loffredo, C. A., Aposhian, H. V., Cebrian, M. E., Yamauchi, H., and Silbergeld, E. K. (2003). Variability in human metabolism of arsenic. Environ. Res. 92(2):85–91.
   Google Scholar
• Lüchtrath, H. (1983). The consequences of chronic arsenic poisoning among Moselle wine growers. Pathoanatomical investigations of post-mortem examinations performed between 1060 and 1977. J. Cancer Res. Clin. Oncol. 105(2):173–182.
   PubMed Web of Science ®Google Scholar
• Luster, M. I., and Simeonova, P. P. (2004). Arsenic and urinary bladder cell proliferation. Toxicol. Appl. Pharmacol. 198:419–423.
   PubMed Web of Science ®Google Scholar
• Mäki-Paakkanen, J., Kurttio, P., Paldy, A., and Pekkanen, J. (1998). Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water. Environ. Mol. Mutagen. 32(4):301–313.
   PubMed Web of Science ®Google Scholar
• Maharjan, M., Watanabe, C., Ahmad, S. A., Umezaki, M., and Ohtsuka, R. (2007). Mutual interaction between nutritional status and chronic arsenic toxicity due to groundwater contamination in an area of Terai, lowland Nepal. J. Epidemiol. Community Health 61(5):389–394.
   PubMed Web of Science ®Google Scholar
• Mahata, J., Basu, A., Ghoshal, S., Sarkar, J. N., Roy, A. K., Poddar, G., Nandy, A. K., Banerjee, A., Ray, K., Natarajan, A. T., Nilsson, R., and Giri, A. K. (2003). Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mut. Res. 534(1–2):133–143.
   Google Scholar
• Mahata, J., Ghosh, P., Sarkar, J. N., Ray, K., Natarajan, A. T., and Giri, A. K. (2004). Effect of sodium arsenite on peripheral lymphocytes in vitro: individual susceptibility among a population exposed to arsenic through the drinking water. Mutagenesis 19(3):223–229.
   PubMed Web of Science ®Google Scholar
• Mandal, B. K., Ogra, Y., Anzai, K., and Suzuki, K. T. (2004). Speciation of arsenic in biological samples. Toxicol. Appl. Pharmacol. 198(3):307–318.
   PubMed Web of Science ®Google Scholar
• Mann, S., Droz, P.-O., and Vahter, M. (1996a). A physiologically based pharmacokinetic model for arsenic exposure. I. Development in hamsters and rabbits. Toxicol. Appl. Pharmacol. 137(1):8–22.
   PubMed Web of Science ®Google Scholar
• Mann, S., Droz, P.-O., and Vahter, M. (1996b). A physiologically based pharmacokinetic model for arsenic exposure. II. Validation and application in humans. Toxicol. Appl. Pharmacol. 140(2):471–486.
   PubMed Web of Science ®Google Scholar
• Marcos, R., Martínez, V., Hernandez, A., Creus, A., Sekaran, C., Tokunaga, H., and Quinteros, D. (2006). Metabolic profile in workers occupationally exposed to arsenic: Role of GST polymorphism. J. Occup. Environ. Med. 48(3):334–341.
   PubMed Web of Science ®Google Scholar
• Marshall, G., Ferreccio, C., Yuan, Y., Bates, M. N., Steinmaus, C., Selvin, S., Liaw, J., and Smith, A. H. (2007). Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water. J. Natl. Cancer. Inst. 99(12):920–928.
   PubMedGoogle Scholar
• Marsit, C. J., Karagas, M. R., Danaee, H., Liu, M., Andrew, A., Schned, A., Nelson, H. H., and Kelsey, K. T. (2006a). Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112–116.
   PubMed Web of Science ®Google Scholar
• Marsit, C. J., Karagas, M. R., Schned, A., Kelsey, K.T., and (2006b). Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Annals of the New York Academy of Sciences 1076:810–821.
   PubMed Web of Science ®Google Scholar
• Martínez, V., Creus, A., Venegas, W., Arroyo, A., Beck, J. P., Gebel, T. W., Surrallés, J., and Marcos, R. (2004). Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic. Mut. Res. 564(1):65–74.
   Google Scholar
• Mass, M. J., Tennant, A., Roop, B. C., Cullen, W. R., Styblo, M., Thomas, D. J., and Kligerman, A. D. (2001). Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14:355–361.
   PubMed Web of Science ®Google Scholar
• McCarty, K. M., Chen, Y.-C., Quamruzzaman, Q., Rahman, M., Mahiuddin, G., Hsueh, Y.-M., Su, L., Smith, T., Ryan, L., and Christiani, D. C. (2007). Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms and skin lesions. Environ. Health Perspect. 115(3):341–345.
   PubMed Web of Science ®Google Scholar
• McDonald, C., Hoque, R., Huda, N., and Cherry, N. (2006). Prevalence of arsenic-related skin lesions in 53 widely-scattered villages of Bangladesh: An ecological survey. J. Health Popul. Nutr. 24:228–235.
   PubMed Web of Science ®Google Scholar
• Meza, M. M., Yu, L., Rodriguez, Y. Y., Guild, M., Thompson, D., Gandolfi, A. J., and Klimecki, W. T. (2005). Developmentally restricted genetic determinants of human arsenic metabolism: Association between urinary methylated arsenic and CYT 19 polymorphisms in children. Environ. Health Perspect. 113(6):775–781.
   PubMed Web of Science ®Google Scholar
• Michaud, D. S., Wright, M. E., Cantor, K. P., Taylor, P. R., Virtamo, J., and Albanes, D. (2004). Arsenic concentrations in prediagnostic toenails and the risk of bladder cancer in a cohort study of male smokers. Am. J. Epidemiol. 160:853–859.
   PubMed Web of Science ®Google Scholar
• Milton, A. H., Hasan, Z., Shahidullah, S. M., Sharmin, S., Jakariya, M. D., Rahman, M., Dear, K., and Smith, W. (2004). Association between nutritional status and arsenicosis due to chronic arsenic exposure in Bangladesh. Int. J. Environ. Health Res. 14:99–108.
   PubMed Web of Science ®Google Scholar
• Milton, A. H., Smith, W., Rahman, B., Hasan, Z., Kulsum, U., Dear, K., Rakibuddin, M., and Ali, A. (2005). Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh. Epidemiology 16(1):82–86.
   PubMed Web of Science ®Google Scholar
• Milton, A. H., Rahman, H., Smith, W., Shrestha, R., and Dear, K. (2006). Water consumption patterns in rural Bangladesh: Are we understimating total arsenic load? J. Water Health 4:431–436.
   PubMedGoogle Scholar
• Mitra, S. R., Guha Mazumder, D. N., Basu, A., Block, G., Haque, R., Samanta, S., Ghosh, N., Smith, M. M. H., von Ehrenstein, O. S., and Smith, A. H. (2004). Nutritional factors and susceptibility to arsenic-caused skin lesions in West Bengal, India. Environ. Health Perspect. 112:1104–1109.
   PubMed Web of Science ®Google Scholar
• Moore, L. E., Smith, A. H., Hopenhayn-Rich, C., Biggs, M. L., Kalman, D. A., and Smith, M. T. (1997). Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol. Biomarkers Prev. 6:31–36.
   PubMed Web of Science ®Google Scholar
• Morales, K. H., Ryan, L., Kuo, T.-L., Wu, M.-M., and Chen, C.-J. (2000). Risk of internal cancers from arsenic in drinking water. Environ. Health Perspect. 108(7):655–661.
   PubMed Web of Science ®Google Scholar
• Mukherjee, B., Salavaggione, O. E., Pelleymounter, L. L., Moon, I., Eckloff, B. W., Schaid, D. J., Wieben, E. D., and Weinshilboum, R. M. (2006). Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Drug Metab. Dispos. 34:1237–1246.
   PubMed Web of Science ®Google Scholar
• Nagy, G., and Korom, I. (1983). Late skin symptoms of arsenic poisoning in the arsenic endemy in Bugac–Alsomonostor [in German]. Z. Hautkr. 58(13):961–964.
   PubMedGoogle Scholar
• Nagy, G., Varga, G., Keresztes, T., and Márfai, L. (1975). Durch Genuß von hoch-arsenhaltigem Wasser verursachte chronische Arsenvergiftungen. Z. Hautkr. 50(5):201–211.
   PubMedGoogle Scholar
• Nakadaira, H., Endoh, K., Katagiri, M., and Yamamoto, M. (2002). Elevated mortality from lung cancer associated with arsenic exposure for a limited duration. J. Occup. Environ. Med. 44:291–299.
   PubMed Web of Science ®Google Scholar
• National Research Council (1999). Arsenic in drinking water. National Academies Press, Washington, DC.
   Google Scholar
• National Research Council (2001). Arsenic in drinking water: 2001 update. National Academies Press, Washington, DC.
   Google Scholar
• Navas-Acien, A., Silbergeld, E. K., Streeter, R. A., Clark, J. M., Burke, T. A., and Guallar, E. (2006). Arsenic exposure and type 2 diabetes: A systematic review of the experimental and epidemiologic evidence. Environ. Health Perspect. 114(5):641–648.
   PubMed Web of Science ®Google Scholar
• Nesnow, S., Roop, B. C., Lambert, G., Kadiiska, M., Mason, R. P., Cullen, W. R., and Mass, M. J. (2002). DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem. Res. Toxicol. 15:1627–1634.
   PubMed Web of Science ®Google Scholar
• Nordenson, I., and Beckman, L. (1982). Occupational and environmental risks in and around a smelter in northern Sweden. VII. Reanalysis and follow-up of chromosomal aberrations in workers exposed to arsenic. Hereditas 96:175–181.
   PubMed Web of Science ®Google Scholar
• Nordenson, I., Beckman, G., Beckman, L., and Nordström, S. (1978). Occupational and environmental risks in and around a smelter in northern Sweden. II. Chromosomal aberrations in workers exposed to arsenic. Hereditas 88:47–50.
   PubMed Web of Science ®Google Scholar
• Nordenson, I., Sweins, A., and Beckman, L. (1981). Chromosome aberrations in cultured human lymphocytes exposed to trivalent and pentavalent arsenic. Scand. J. Work Environ. Health 7:277–281.
   PubMed Web of Science ®Google Scholar
• Ohno, K., Yanase, T., Matsuo, Y., Kimura, T., Rahman, M. H., Magara, Y., and Matsiu, Y. (2007). Arsenic intake via water and food by a population living in an arsenic-affected area of Bangladesh. Sci. Total Environ. 381:68–76.
   PubMed Web of Science ®Google Scholar
• Okoji, R. S., Yu, R. C., Maronpot, R. R., and Froines, J. R. (2002). Sodium arsenite administration via dringing water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis 23:777–785.
   PubMed Web of Science ®Google Scholar
• Ostrosky-Wegman, P., Gonsebatt, M. E., Montero, R., Vega, L., Barba, H., Espinosa, J., Palao, A., Cortinas, C., Garcia-Vargas, G., del Razo, L.M., and Cebrian, M. (1991). Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico. Mut. Res. 250:477–482.
   Google Scholar
• Oya-Ohta, Y., Kaise, T., and Ochi, T. (1996). Induction of chromosomal aberrations in cultured human fibroblasts by inorganic and organic arsenic compounds and the different roles of glutathione in such induction. Mut. Res. 357:123–129.
   Google Scholar
• Parish, W. R., and Burnett, J. W. (1987). Arsenic exposure: The cutaneous manifestations. Cutis 40:401–402.
   Web of Science ®Google Scholar
• Piontek, M., Hengels, K.J., Borchard, F., and Strohmeyer, G. (1989). Nicht-zirrhotische Leberfibrose nach chronischer Arsenintoxikation. Dtsch. Med. Wochenschr. 114(43):1653–1657.
   PubMedGoogle Scholar
• Pott, W. A., Benjamin, S. A., and Yang, R. S. H. (2001). Pharmacokinetics, metabolism, and carcinogenicity of arsenic. Rev. Environ. Contam. Toxicol. 169:165–214.
   PubMed Web of Science ®Google Scholar
• Pu, Y.-S., Yang, S.-M., Huang, Y.-K., Chung, C.-J., Huang, S. K., Chiu, A.W.-H., Yang, M.-H., Chen, C.-J., and Hsueh, Y.-M. (2007). Urinary arsenic profile affects the risk of urothelial carcinoma even at low arsenic exposure. Toxicol. Appl. Pharmacol. 218(2):99–106.
   PubMed Web of Science ®Google Scholar
• Rahman, M., Tondel, M., Ahmad, S. A., and Axelson, O. (1998). Diabetes mellitus associated with arsenic exposure in Bangladesh. Am. J. Epidemiol. 148:198–203.
   PubMed Web of Science ®Google Scholar
• Rahman, M., Vahter, M., Sohel, N., Yunus, M., Wahed, M. A., Streatfield, P. K., Ekström, E.-C., and Persson, L. A. (2006). Arsenic exposure and age- and sex-specific risk for skin lesions: a population based case-referent study in Bangladesh. Environ. Health Perspect. 114(12):1847–1852.
   PubMed Web of Science ®Google Scholar
• Ramírez, P., Eastmond, D. A., Laclette, J. P., and Ostrosky-Wegman, P. (1997). Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mut. Res. 386:291–298.
   Google Scholar
• Reichard, J. F., Schnekenburger, M., and Puga, A. (2007). Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem. Biophys. Res. Commun. 352:188–192.
   PubMed Web of Science ®Google Scholar
• Rossman, T.G. (2003). Mechanism of arsenic carcinogenesis: an integrated approach. Mut. Res. 533:37–65.
   Google Scholar
• RoyChoudhury, A., Das, T., Sharma, A., and Talukder, G. (1996). Dietary garlic extract in modifying clastogenic effects of inorganic arsenic in mice: Two-generation studies. Mut. Res. 359:165–170.
   Google Scholar
• Rudel, R., Slayton, T. M., and Beck, B. D. (1996). Implications of arsenic genotoxicity for dose response of carcinogenic effects. Regul. Toxicol. Pharmacol. 23(2):87–105.
   PubMed Web of Science ®Google Scholar
• Saha, K. C. 2003. Diagnosis of arsenicosis. J. Environ. Sci. Health A38:255–272.
   Google Scholar
• Saleha Banu, B., Danadevi, K., Jamil, K., Ahuja, Y. R., Visweswara, R. K., and Ishaq, M. (2001). In vivo genotoxic effect of arsenic trioxide in mice using comet assay. Toxicology 162:171–177.
   PubMed Web of Science ®Google Scholar
• Schaumlöffel, N., and Gebel, T. (1998). Heterogeneity of the DNA damage provoked by antimony and arsenic. Mutagenesis 12:281–286.
   Google Scholar
• Schläwicke Engström, K., Broberg, K., Concha, G., Nermell, B., Warholm, M., and Vahter, M. (2007). Genetic polymorphisms influencing arsenic metabolism—Evidence from Argentina. Environ. Health Perspect. 115(4):599–605.
   PubMed Web of Science ®Google Scholar
• Schoen, A., Beck, B., Sharma, R., and Dubé, E. (2004). Arsenic toxicity at low doses: epidemiological and mode of action considerations. Toxicol. Appl. Pharmacol. 198:253–267.
   PubMed Web of Science ®Google Scholar
• Schwartz, R. A. (1996). Premalignant keratinocytic neoplasms. J. Am. Acad. Dermatol. 35:223–242.
   PubMed Web of Science ®Google Scholar
• Schwerdtle, T., Walter, I., Mackiw, I., and Hartwig, A. (2003a). Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis 24(5):967–974.
   PubMed Web of Science ®Google Scholar
• Schwerdtle, T., Walter, I., and Hartwig, A. (2003b). Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg. DNA Repair 2:1449–1463.
   PubMed Web of Science ®Google Scholar
• Shannon, R. L., and Strayer, D. S. (1989). Arsenic-induced skin toxicity. Hum. Toxicol. 8:99–104.
   Web of Science ®Google Scholar
• Shen, S., Lee, J., Weinfeld, M., and Le, X. C. (2008). Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis. Mol. Carcinog., in press.
   Web of Science ®Google Scholar
• Shi, H., Shi, X., and Liu, K. J. (2004). Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol. Cell. Biochem. 255:67–78.
   PubMed Web of Science ®Google Scholar
• Slob, W. (1999). Thresholds in toxicology and risk assessment. Int. J. Toxicol. 18(4):259–268.
   Web of Science ®Google Scholar
• Smith, A. H., Marshall, G., Yuan, Y., Ferreccio, C., Liaw, J., von Ehrenstein, O., Steinmaus, C., Bates, M. N., and Selvin, S. (2006). Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ. Health Perspect. 114:1293–1296.
   PubMed Web of Science ®Google Scholar
• Smith, N. M., Lee, R., Heitkemper, D. T., Cafferky, K. D., Haque, A., and Henderson, A. K. (2006). Inorganic arsenic in cooked rice and vegetables from Bangladeshi households. Sci. Total Environ. 370:294–301.
   PubMed Web of Science ®Google Scholar
• Sordo, M., Herrera, L. A., Ostrosky-Wegman, P., and Rojas, E. (2001). Cytotoxic and genotoxic effects of As, MMA, and DMA on leukocytes and stimulated human lymphocytes. Teratog. Carcinog. Mutagen. 21:249–260.
   PubMedGoogle Scholar
• Steinmaus, C., Yuan, Y., Bates, M. N., and Smith, A. H. (2003). Case–control study of bladder cancer and drinking water arsenic in the western United States. Am. J. Epidemiol. 158:1193–1201.
   PubMed Web of Science ®Google Scholar
• Steinmaus, C., Carrigan, K., Kalman, D., Atallah, R., Yuan, Y., and Smith, A. H. (2005). Dietary intake and arsenic methylation in a US population. Environ. Health Perspect. 113(9):1153–1159.
   PubMed Web of Science ®Google Scholar
• Steinmaus, C., Moore, L. E., Shipp, M., Kalman, D., Rey, O. A., Biggs, M. L., Hopenhayn, C., Bates, M. N., Zheng, S., Wiencke, J. K., and Smith, A. H. (2007). Genetic polymorphism in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. J. Toxicol. Environ. Health A 70(2):159–170.
   PubMed Web of Science ®Google Scholar
• Stýblo, M., Drobná, Z., Jaspers, I., Lin, S., and Thomas, D. J. (2002). The role of biomethylation in toxicity and carcinogenicity of arsenic: A research update. Environ. Health Perspect. 110(Suppl 5):767–771.
   PubMedGoogle Scholar
• Sykora, P., and Snow, E. T. (2008). Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite. Toxicol. Appl. Pharmacol. 228(3):385–394.
   PubMed Web of Science ®Google Scholar
• Tapio, S., and Grosche, B. (2006). Arsenic in the aetiology of cancer. Mut. Res. 612(3):215–246.
   Google Scholar
• Tice, R. R., Yager, J. W., Andrews, P., and Crecelius, E. (1997). Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite. Mut. Res. 386:315–334.
   Google Scholar
• Thomas, D. J. (2007). Molecular processes in cellular arsenic metabolism. Toxicol. Appl. Pharmacol. 222(3):365–373.
   PubMed Web of Science ®Google Scholar
• Tollestrup, K., Frost, F. J., Cristiani, M., McMillan, G. P., Calderon, R. L., and Padilla, R. S. (2005). Arsenic-induced skin conditions identified in southwest dermatology practices: An epidemiologic tool? Environ. Geochem. Health 27:47–53.
   Web of Science ®Google Scholar
• Tran, H.P., Prakash, A.S., Barnard, R., Chiswell, B., and Ng, J.C. (2002). Arsenic inhibits the repair of DNA damage induced by benzo(a)pyrene. Toxicol. Lett. 133:59–67.
   Google Scholar
• Tsai, S.-Y., Chou, H.-Y., The, H.-W., Chen, C.-M., and Chen, C.-J. (2003). The effect of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 24:747–753.
   PubMed Web of Science ®Google Scholar
• Tseng, H.-P., Wang, Y.-H., Wu, M.-M., The, H.-W., Chiou, H.-Y., and Chen, C.-J. (2006). Association between chronic exposure to arsenic and slow nerve conduction velocity among adolescents in Taiwan. J. Health Popul. Nutr. 24(2):182–189.
   PubMed Web of Science ®Google Scholar
• Tseng, C. H. (2007). Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective. J. Environ. Sci. Health C 25(1):1–22.
   Google Scholar
• Tseng, W. P. (1977). Effects and dose–response relationship of skin cancer and blackfoot disease with arsenic. Environ. Health Perspect. 19:109–119.
   PubMed Web of Science ®Google Scholar
• Tseng, W. P., Chu, H. M., How, S. W., Fong, J. M., Lin, C. S., and Yeh, S. (1968). Prevalence of skin cancer in an endemic area of chronic arsenism in Taiwan. J. Natl. Cancer Inst. 40:453–463.
   PubMed Web of Science ®Google Scholar
• Vahter, M., and Concha, G. (2001). Role of metabolism in arsenic toxicity. Pharmacol. Toxicol. 89(1):1–5.
   Web of Science ®Google Scholar
• Vahter, M., Akeson, A., Lidén, C., Ceccatelli, S., and Berglund, M. (2007). Gender differences in the disposition and toxicity of metals. Environ. Res. 104(1):85–95.
   Google Scholar
• Valenzuela, O. L., Borja-Aburto, V. H., Garcia-Vargas, G. G., Cruz-Gonzalez, M. B., Garcia-Montalvo, E. A., Calderon-Aranda, E. S., and Del Razo, L. M. (2005). Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic. Environ. Health Perspect. 113(3):250–254.
   PubMed Web of Science ®Google Scholar
• Vega, L., Stýblo, M., Patterson, R., Cullen, W., Wang, C., and Germolec, D. (2001). Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 172:225–232.
   PubMed Web of Science ®Google Scholar
• Vig, B. K., Figueroa, M. L., Cornforth, M. N., and Jenkins, S. H. (1984). Chromosome studies in human subjects chronically exposed to arsenic in drinking water. Am. J. Ind. Med. 6:325–338.
   PubMed Web of Science ®Google Scholar
• von Ehrenstein, O. S., Guha Mazumder, D. N., Hira-Smith, M., Ghosh, N., Yuan, Y., Windham, G., Ghosh, A., Haque, R., Lahiri, S., Kalman, D., Das, S., and Smith, A. H. (2006). Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India. Am. J. Epidemiol. 163(7):662–669.
   PubMed Web of Science ®Google Scholar
• Waalkes, M. P., Ward, J. M., Liu, J., and Diwan, B. A. (2003). Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice. Toxicol. Appl. Pharmacol. 186(1):7–17.
   PubMed Web of Science ®Google Scholar
• Waalkes, M. P., Liu, J., Ward, J. M., and Diwan, B. A. (2006a). Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen. Toxicol. Appl. Pharmacol. 215(3):295–305.
   PubMed Web of Science ®Google Scholar
• Waalkes, M. P., Liu, J., Ward, J. M., Powell, D. A., and Diwan, B. A. (2006b). Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment. Cancer Res. 66(3):1337–1345.
   PubMed Web of Science ®Google Scholar
• Walter, I., Schwerdtle, T., Thuy, C., Parsons, J. L., Dianov, G. L., and Hartwig, A. (2007). Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA Repair 6:61–70.
   PubMed Web of Science ®Google Scholar
• Wang, T.-S., Shu, Y.-F., Liu, Y.-C., Jan, K.-Y., and Huang, H. (1997). Glutathione peroxidase and catalase modulate the genotoxicity of arsenite. Toxicology 121:229–237.
   PubMed Web of Science ®Google Scholar
• Wang, T.-S., Chung, C.-H., Wang, A. S. S., Bau, D.-T., Samikkannu, T., Jan, K.-Y., Cheng, Y.-M., and Lee, T.-C. (2002). Endonuclease III, formamidopyrimidine-DNA glycosylase, and proteinase K additively enhance arsenic-induced DNA strand breaks in human cells. Chem. Res. Toxicol. 15(10):1254–1258.
   PubMed Web of Science ®Google Scholar
• Wang, A., Holladay, S., Wolf, D., Ahmed, S., and Robertson, J. (2006). Reproductive and developmental toxicity of arsenic in rodents: A review. Int. J. Toxicol. 25:319–331.
   PubMed Web of Science ®Google Scholar
• Wang, S.-X., Wang, Z.-H., Cheng, X.-T., Li, J., Sang, Z.-P., Zhang, X.-D., Han, L.-L., Qiao, X.-Y., Wu, Z.-M., and Wang, Z.-Q. (2007). Arsenic and fluoride exposure in drinking water: Children's IQ and growth in Shanyin County, Shanxi Province, China. Environ. Health Perspect. 115(4):643–647.
   PubMed Web of Science ®Google Scholar
• Warner, M. L., Moore, L. E., Smith, M. T., Kalman, D. A., Fanning, E., and Smith, A. H. (1994). Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arsenic-contaminated water in Nevada. Cancer Epidemiol. Biomarkers Prev. 3(7):583–590.
   PubMed Web of Science ®Google Scholar
• Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Factor-Litvak, P., van Geen, A., Slavkovich, V., LoIacono, N. J., Cheng, Z., Hussain, I., Momotaj, H., and Graziano, J. H. (2004). Water arsenic exposure and children's intellectual function in Araihazar, Bangladesh. Environ. Health Perspect. 112(9):1329–1333.
   PubMedGoogle Scholar
• Wasserman, G. A., Liu, X., Parvez, F., Ahsan, H., Factor-Litvak, P., Kline, J., van Geen, A., Slavkovich, V., LoIacono, N. J., Levy, D., Cheng, Z., and Graziano, J. H. (2007). Water arsenic exposure and intellectual function in six-year-old children in Araihazar, Bangladesh. Environ. Health Perspect. 115(2):285–289.
   PubMed Web of Science ®Google Scholar
• Watanabe, C. (2001). Environmental arsenic exposure in Bangladesh: Water versus extra-water intake of arsenic. Environ Sci 8:459–466.
   Google Scholar
• Watanabe, C., Kawata, A., Sudo, N., Sekiyama, M., Inaoka, T., Bae, M., and Ohtsuka, R. (2004). Water intake in an Asian population living in arsenic-contaminated area. Toxicol. Appl. Pharmacol. 198:272–282.
   PubMed Web of Science ®Google Scholar
• Wei, M., Wanibuchi, H., Morimura, K., Iwai, S., Yoshida, K., Endo, G., Nakae, D., and Fukushima, S. (2002). Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis 23:1387–1397.
   PubMed Web of Science ®Google Scholar
• Williams, P. N., Price, A. H., Raab, A., Hossain, S. A., Feldmann, J., and Meharg, A. A. (2005). Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. Environ. Sci. Technol. 39:5531–5540.
   PubMed Web of Science ®Google Scholar
• Williams, P. N., Islam, M. R., Adomako, E. E., Raab, A., Hossain, S. A., Zhu, Y. G., Feldmann, J., and Meharg, A. A. (2006). Increase in rice grain arsenic for regions of Bangladesh irrigating paddies with elevated arsenic in groundwaters. Environ. Sci. Technol. 40:4903–4908.
   PubMed Web of Science ®Google Scholar
• Witkiewicz-Kucharczyk, A., and Bal, W. (2006). Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol. Lett. 162:29–42.
   Google Scholar
• World Health Organization (1993). Guidelines for drinking-water quality. Vol. 1. Recommendations. 2nd ed. World Health Organisation, Geneva.
   Google Scholar
• World Health Organization (2001). Environmental health criteria 224, arsenic and arsenic compounds. 2nd ed. World Health Organization, Geneva.
   Google Scholar
• Wu, M.-M., Kuo, T.-L., Hwang, Y.-H., and Chen, C.-J. (1989). Dose–response relation between arsenic well water and mortality from cancer. Am. J. Epidemiol. 130:1123–1132.
   PubMed Web of Science ®Google Scholar
• Yamanaka, K., Hasegawa, A., Sawamura, R., and Okada, S. (1989). Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice. Biochem. Biophys. Res. Commun. 165:43–50.
   PubMed Web of Science ®Google Scholar
• Yamanaka, K., Kato, K., Mizoi, M., An, Y., Takabayashi, F., Nakano, M., Hoshino, M., and Okada, S. (2004). The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. Toxicol. Appl. Pharmacol. 198(3):385–393.
   PubMed Web of Science ®Google Scholar
• Yamauchi, H., Aminaka, Y., Yoshida, K., Sun, G., Pi, J., and Waalkes, M. P. (2004). Evaluation of DNA damage in patients with arsenic poisoning: Urinary 8-hydroxydeoxyguanine. Toxicol. Appl. Pharmacol. 198(3):291–296.
   PubMed Web of Science ®Google Scholar
• Yang, C., and Frenkel, K. (2002). Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis. J. Environ. Pathol. Toxicol. Oncol. 21(4):331–342.
   PubMedGoogle Scholar
• Yu, R. C., Hsu, K. H., Chen, C. J., and Froines, J. R. (2000). Arsenic methylation capacity and skin cancer. Cancer Epidemiol. Biomarkers Prev. 9:1259–1262.
   PubMed Web of Science ®Google Scholar
• Zhang, T. C., Schmitt, M. T., and Mumford, J. L. (2003). Effects of arsenic on telomrase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro. Carcinogenesis 24:1811–1817.
   PubMed Web of Science ®Google Scholar