The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)

References

• Abe K, Kato N, Miki K, Nimura S, Suzuki M, Kiyota H, Onodera S, Oishi Y. 2002. Malignant mesothelioma of testicular tunica vaginalis. Int J Urol. 9:602–603.
   PubMed Web of Science ®Google Scholar
• Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP. 2011. EAU guidelines on testicular cancer: 2011 update. Eur Urol. 60:304–319.
   PubMed Web of Science ®Google Scholar
• Alekshun TJ, Tao J, Sokol L. 2007. Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature. Am J Hematol. 82:481–485.
   PubMed Web of Science ®Google Scholar
• Amin KM, Litzky LA, Smythe WR, Mooney AM, Morris JM, Mews DJ, Pass HI, Kari C, Rodeck U, Rauscher FJ, III, et al. 1995. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol. 146:344–356.
   PubMed Web of Science ®Google Scholar
• Attanoos RL, Gibbs AR. 1997. Pathology of malignant mesothelioma. Histopathology. 30:403–418.
   PubMed Web of Science ®Google Scholar
• Attanoos RL, Griffin A, Gibbs AR. 2003. The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2. Histopathology. 43:231–238.
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay A, Bhattacharya S, Konar K. 2015. Preoperative cytological diagnosis of malignant mesothelioma of tunica vaginalis. Diagn Cytopathol. 43:850–854.
   PubMed Web of Science ®Google Scholar
• Barbera V, Rubino M. 1957. Papillary mesothelioma of the tunica vaginalis. Cancer. 10:183–189.
   PubMed Web of Science ®Google Scholar
• Ben-Eliyahu S, Page GG, Yirmiya R, Shakhar G. 1999. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer. 80:880–888.
   PubMed Web of Science ®Google Scholar
• Bisceglia M, Dor DB, Carosi I, Vairo M, Pasquinelli G. 2010. Paratesticular mesothelioma. Report of a case with comprehensive review of literature. Adv Anat Pathol. 17:53–70.
   PubMed Web of Science ®Google Scholar
• Boorman G, Chapin R, Mitsumori K. 1990. Testis and epididymis. In: Boorman G, Eustis S, Elwell M, Montgomery C, Jr, MacKenzie W, editors. Pathology of the Fischer rat. Reference and Atlas. New York: Academic Press. p. 405–418.
   Google Scholar
• Boyum J, Wasserman NF. 2008. Malignant mesothelioma of the tunica vaginalis testis: a case illustrating Doppler color flow imaging and its potential for preoperative diagnosis. J Ultrasound Med. 27:1249–1255.
   PubMed Web of Science ®Google Scholar
• Caldwell DJ. 1999. Review of mononuclear cell leukemia in F-344 rat bioassays and its significance to human cancer risk: a case study using alkyl phthalates. Regul Toxicol Pharmacol. 30:45–53.
   PubMed Web of Science ®Google Scholar
• Cameron TP, Hickman RL, Kornreich MR, Tarone RE. 1985. History, survival, and growth patterns of B6C3F1 mice and F344 rats in the National Cancer Institute Carcinogenesis Testing Program. Fundam Appl Toxicol. 5:526–538.
   PubMedGoogle Scholar
• Chan J, Jaffe E, Ralfkiaer E, Ko JH. 2008b. Aggressive NK-cell leukemia. In: Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, Thiele J, Vardiman J, editors. World Health Organization classification of tumours of hematopoietic and lymphoid tissues. Lyon: IARC Press. p. 276–277.
   Google Scholar
• Chan W, Foucar K, Morice W, Catovsky D. 2008a. T-cell large granular lymphocytic leukemia. In: Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, Thiele J, Vardiman J, editors. World Health Organization classification of tumours of hematopoietic and lymphoid tissues. Lyon: IARC Press. p. 272–273.
   Google Scholar
• Chekol SS, Sun CC. 2012. Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. Arch Pathol Lab Med. 136:113–117.
   PubMed Web of Science ®Google Scholar
• Chen JL, Hsu YH. 2009. Malignant mesothelioma of the tunica vaginalis testis: a case report and literature review. Kaohsiung J Med Sci. 25:77–81.
   PubMed Web of Science ®Google Scholar
• Cheung MM, Chan JK, Wong KF. 2003. Natural killer cell neoplasms: a distinctive group of highly aggressive lymphomas/leukemias. Semin Hematol. 40:221–232.
   PubMed Web of Science ®Google Scholar
• Cheville JC. 1999. Classification and pathology of testicular germ cell and sex cord-stromal tumors. Urol Clin North Am. 26:595–609.
   PubMed Web of Science ®Google Scholar
• Churg A. 2003. Paratesticular mesothelial proliferations. Semin Diagn Pathol. 20:272–278.
   PubMed Web of Science ®Google Scholar
• Cohen SM, Klaunig J, Meek ME, Hill RN, et al. 2004. Evaluating the human relevance of chemically induced animal tumors. Toxicol Sci. 78:181–186.
   PubMed Web of Science ®Google Scholar
• Coleman GL, Barthold W, Osbaldiston GW, Foster SJ, Jonas AM. 1977. Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol. 32:258–278.
   PubMedGoogle Scholar
• Cook JC, Klinefelter GR, Hardisty JF, Sharpe RM, Foster PM. 1999. Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. Crit Rev Toxicol. 29:169–261.
   PubMed Web of Science ®Google Scholar
• Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, et al. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol. 40:40S–121S.
   PubMed Web of Science ®Google Scholar
• Davey FR, Moloney WC. 1970. Postmortem observations on Fischer rats with leukemia and other disorders. Lab Invest. 23:327–334.
   PubMed Web of Science ®Google Scholar
• Dieter MP, Jameson CW, French JE, Gangjee S, Stefanski SA, Chhabra RS, Chan PC. 1989. Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals. Leuk Res. 13:841–849.
   PubMed Web of Science ®Google Scholar
• Dieter MP, Jameson CW, Maronpot RR, Langenbach R, Braun AG. 1990. The chemotherapeutic potential of glycol alkyl ethers: structure-activity studies of nine compounds in a Fischer-rat leukemia transplant model. Cancer Chemother Pharmacol. 26:173–180.
   PubMed Web of Science ®Google Scholar
• Dieter MP, Maronpot RR, French JE. 1985. Comparison of the morphology and enzyme activity of mononuclear cells from Fischer 344 rats with either spontaneous or transplanted leukemia. Cancer Res. 45:4301–4307.
   PubMed Web of Science ®Google Scholar
• Dunnick JK, Eustis SL, Huff JE, Haseman JK. 1989. Two-year toxicity and carcinogenicity studies of ampicillin trihydrate and penicillin VK in rodents. Fundam Appl Toxicol. 12:252–257.
   PubMedGoogle Scholar
• Dunning WF, Curtis MR. 1946. The respective roles of longevity and genetic specificity in the occurrence of spontaneous tumors in the hybrids between two inbred lines of rats. Cancer Res. 6:61–81.
   PubMed Web of Science ®Google Scholar
• Dunning WF, Curtis MR. 1957. A transplantable acute leukemia in an inbred line of rats. J Natl Cancer Inst. 19:845–853.
   PubMedGoogle Scholar
• Elwell MR, Dunnick JK, Hailey JR, Haseman JK. 1996. Chemicals associated with decreases in the incidence of mononuclear cell leukemia in the Fischer rat. Toxicol Pathol. 24:238–245.
   PubMed Web of Science ®Google Scholar
• EPA. 2005. Guidelines for carcinogen risk assessment. EPA/630/P=03/001F. Washington, DC: Environmental Protection Agency. p. 166.
   Google Scholar
• Erdogan S, Acikalin A, Zeren H, Gonlusen G, Zorludemir S, Izol V. 2014. Well-differentiated papillary mesothelioma of the tunica vaginalis: a case study and review of the literature. Korean J Pathol. 48:225–228.
   PubMedGoogle Scholar
• Farkas LM, Szekely JG, Pusztai C, Baki M. 2000. High frequency of metastatic Leydig cell testicular tumours. Oncology. 59:118–121.
   PubMed Web of Science ®Google Scholar
• Fernandez GC, Tardaguila F, Rivas C, Trinidad C, Pesqueira D, Zungri E, San Miguel P. 2004. Case report: MRI in the diagnosis of testicular Leydig cell tumour. Br J Radiol. 77:521–524.
   PubMed Web of Science ®Google Scholar
• Friedman MA, Dulak LH, Stedham MA. 1995. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol. 27:95–105.
   PubMedGoogle Scholar
• Frith CH. 1988. Morphologic classification and incidence of hematopoietic neoplasms in the Sprague-Dawley rat. Toxicol Pathol. 16:451–457.
   PubMed Web of Science ®Google Scholar
• Frith CH, Ward JM, Chandra M. 1993. The morphology, immunohistochemistry, and incidence of hematopoietic neoplasms in mice and rats. Toxicol Pathol. 21:206–218.
   PubMed Web of Science ®Google Scholar
• Gana BM, Windsor PM, Lang S, Macintyre J, Baxby K. 1995. Leydig cell tumour. Br J Urol. 75:676–678.
   PubMedGoogle Scholar
• Garriga V, Serrano A, Marin A, Medrano S, Roson N, Pruna X. 2009. US of the tunica vaginalis testis: anatomic relationships and pathologic conditions. Radiographics. 29:2017–2032.
   PubMed Web of Science ®Google Scholar
• Gentile TC, Uner AH, Hutchison RE, Wright J, Ben-Ezra J, Russell EC, Loughran TP, Jr. 1994. CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia. Blood. 84:2315–2321.
   PubMed Web of Science ®Google Scholar
• Gerris J, Schoysman R. 1984. Tunica vaginalis fluid (TVF): hormonal composition. Assessment of testosterone, 5 alpha-dihydrotestosterone, delta 4-androstenedione, dehydroepiandrosteronesulphate, estradiol, LH, FSH and PRL. Acta Eur Fertil. 15:205–216.
   PubMedGoogle Scholar
• Gerwin BI, Lechner JF, Reddel RR, Roberts AB, Robbins KC, Gabrielson EW, Harris CC. 1987. Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res. 47:6180–6184.
   PubMed Web of Science ®Google Scholar
• Giannarini G, Dieckmann KP, Albers P, Heidenreich A, Pizzocaro G. 2010. Organ-sparing surgery for adult testicular tumours: a systematic review of the literature. Eur Urol. 57:780–790.
   PubMed Web of Science ®Google Scholar
• Giwercman A, Grindsted J, Hansen B, Jensen OM, Skakkebaek NE. 1987. Testicular cancer risk in boys with maldescended testis: a cohort study. J Urol. 138:1214–1216.
   PubMed Web of Science ®Google Scholar
• Goel A, Agrawal A, Gupta R, Hari S, Dey AB. 2008. Malignant mesothelioma of the tunica vaginalis of the testis without exposure to asbestos. Cases J. 1:310.
   PubMedGoogle Scholar
• Gonzalez M, Merlani P, Egger JF, Pugin F, Morel P. 2007. Hemorrhagic shock caused by rupture of an intra-abdominal leydig cell tumour: case report. Case Rep Gastroenterol. 1:53–58.
   PubMedGoogle Scholar
• Goodman D, Boorman G, Strandberg J. 1985. Selection and use of the B6C3F1 mouse and F344 rat in long-term assays for carcinogenicity. In: Millman H, Weisburger E, editors. Handbook of carcinogen testing. New Jersey: Noyes Publications. p. 282–320.
   Google Scholar
• Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS. 1979. Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol. 48:237–248.
   PubMed Web of Science ®Google Scholar
• Goodman G, Wilson R. 1991. Predicting the carcinogenicity of chemicals in humans from rodent bioassay data. Environ Health Perspect. 94:195–218.
   PubMed Web of Science ®Google Scholar
• Guney N, Basaran M, Karayigit E, Muslumanoglu A, Guney S, Kilicaslan I, Gulbarut S. 2007. Malignant mesothelioma of the tunica vaginalis testis: a case report and review of the literature. Med Oncol. 24:449–452.
   PubMed Web of Science ®Google Scholar
• Hamm M, Rupp C, Rottger P, Rathert P. 1999. [Malignant mesothelioma of the tunica vaginalis testis]. Chirurg. 70:302–305.
   PubMed Web of Science ®Google Scholar
• Harada T, Maronpot RR, Morris RW, Boorman GA. 1990. Effects of mononuclear cell leukemia on altered hepatocellular foci in Fischer 344 rats. Vet Pathol. 27:110–116.
   PubMed Web of Science ®Google Scholar
• Hart DN, Baker BW, Inglis MJ, Nimmo JC, Starling GC, Deacon E, Rowe M, Beard ME. 1992. Epstein-Barr viral DNA in acute large granular lymphocyte (natural killer) leukemic cells. Blood. 79:2116–2123.
   PubMed Web of Science ®Google Scholar
• Haseman JK. 1983. A reexamination of false-positive rates for carcinogenesis studies. Fundam Appl Toxicol. 3:334–339.
   PubMedGoogle Scholar
• Haseman JK, Hailey JR, Morris RW. 1998. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicol Pathol. 26:428–441.
   PubMed Web of Science ®Google Scholar
• Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, McConnell EE. 1985. Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice. J Natl Cancer Inst. 75:975–984.
   PubMed Web of Science ®Google Scholar
• Haseman JK, Ney E, Nyska A, Rao GN. 2003. Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies. Toxicol Pathol. 31:674–681.
   PubMed Web of Science ®Google Scholar
• Haseman JK, Rao GN. 1992. Effects of corn oil, time-related changes, and inter-laboratory variability on tumor occurrence in control Fischer 344 (F344/N) rats. Toxicol Pathol. 20:52–60.
   PubMed Web of Science ®Google Scholar
• Haseman JK, Young E, Eustis SL, Hailey JR. 1997. Body weight-tumor incidence correlations in long-term rodent carcinogenicity studies. Toxicol Pathol. 25:256–263.
   PubMed Web of Science ®Google Scholar
• Hassan R, Alexander R. 2005. Nonpleural mesotheliomas: mesothelioma of the peritoneum, tunica vaginalis, and pericardium. Hematol Oncol Clin North Am. 19:1067–1087, vi.
   PubMed Web of Science ®Google Scholar
• Hasserjian RP, Harris NL. 2007. NK-cell lymphomas and leukemias: a spectrum of tumors with variable manifestations and immunophenotype. Am J Clin Pathol. 127:860–868.
   PubMed Web of Science ®Google Scholar
• Hellman S, Moloney WC, Meissner WA. 1982. Paradoxical effect of radiation on tumor incidence in the rat: implications for radiation therapy. Cancer Res. 42:433–436.
   PubMed Web of Science ®Google Scholar
• Hendry J, Fraser S, White J, Rajan P, Hendry DS. 2015. Retroperitoneal lymph node dissection (RPLND) for malignant phenotype Leydig cell tumours of the testis: a 10-year experience. Springerplus. 4:20.
   PubMed Web of Science ®Google Scholar
• Hiraga K, Fujii T. 1985. Carcinogenicity testing of acetaminophen in F344 rats. Jpn J Cancer Res. 76:79–85.
   PubMedGoogle Scholar
• Hoei-Hansen CE, Holm M, Rajpert-De Meyts E, Skakkebaek NE. 2003. Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol. 200:370–374.
   PubMed Web of Science ®Google Scholar
• Huff JE. 1994. Chemicals causally associated with cancers in humans and laboratory animals. A perfect concordance. In: Waalkes MP, Ward JM, editors. Carcinogenesis. New York: Raven Press. p. 25–37.
   Google Scholar
• Hursting SD, Switzer BR, French JE, Kari FW. 1993. The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats. Cancer Res. 53:2750–2757.
   PubMed Web of Science ®Google Scholar
• Hursting SD, Switzer BR, French JE, Kari FW. 1994. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 15:193–199.
   PubMed Web of Science ®Google Scholar
• Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB, Borczuk AC, Butnor K, Cagle PT, Chirieac LR, et al. 2013. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med. 137:647–667.
   PubMed Web of Science ®Google Scholar
• Ikegami Y, Kawai N, Tozawa K, Hayashi Y, Kohri K. 2008. Malignant mesothelioma of the tunica vaginalis testis related to recent asbestos. Int J Urol. 15:560–561.
   PubMed Web of Science ®Google Scholar
• Ilgren E. 1993. Mesotheliomas of animals: a comprehensive tabular compendium of the world's literature. Oxford: CRC Press.
   Google Scholar
• Ilgren EB, Wagner JC. 1991. Background incidence of mesothelioma: animal and human evidence. Regul Toxicol Pharmacol. 13:133–149.
   PubMed Web of Science ®Google Scholar
• Imai K, Yoshimura K, Yamaguchi K, Matsui E, Isaka H, Hashimoto K, Boorman G. 1990. Effects of dietary restriction on age-associated pathologic changes in F-344 rats. J Toxicol Pathol. 3:209–221.
   Google Scholar
• Inbar S, Neeman E, Avraham R, Benish M, Rosenne E, Ben-Eliyahu S. 2011. Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity. PLoS One. 6:e19246.
   Google Scholar
• Johansson P, Bergmann A, Rahmann S, Wohlers I, Scholtysik R, Przekopowitz M, Seifert M, Tschurtschenthaler G, Webersinke G, Jager U, et al. 2015. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia. Int J Cancer. 138:121–124.
   PubMed Web of Science ®Google Scholar
• Johnson KA, Gorzinski SJ, Bodner KM, Campbell RA, Wolf CH, Friedman MA, Mast RW. 1986. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol. 85:154–168.
   PubMed Web of Science ®Google Scholar
• Jones MA, Young RH, Scully RE. 1995. Malignant mesothelioma of the tunica vaginalis. A clinicopathologic analysis of 11 cases with review of the literature. Am J Surg Pathol. 19:815–825.
   PubMed Web of Science ®Google Scholar
• Karpe B, Fredricsson B, Svensson J, Ritzen EM. 1982. Testosterone concentration within the tunica vaginalis of boys and adult men. Int J Androl. 5:549–556.
   PubMedGoogle Scholar
• Kato R, Matsuda Y, Maehana T, Miyao N, Konishi Y, Kon S. 2012. Intrascrotal malignant mesothelioma diagnosed after surgery for hydrocele testis: a case report. Hinyokika Kiyo. 58:45–48.
   PubMedGoogle Scholar
• Kato Y, Tsuta K, Seki K, Maeshima AM, Watanabe S, Suzuki K, Asamura H, Tsuchiya R, Matsuno Y. 2007. Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol. 20:215–220.
   PubMed Web of Science ®Google Scholar
• Kawa-Ha K, Ishihara S, Ninomiya T, Yumura-Yagi K, Hara J, Murayama F, Tawa A, Hirai K. 1989. CD3-negative lymphoproliferative disease of granular lymphocytes containing Epstein-Barr viral DNA. J Clin Invest. 84:51–55.
   PubMed Web of Science ®Google Scholar
• Kim I, Young RH, Scully RE. 1985. Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol. 9:177–192.
   PubMed Web of Science ®Google Scholar
• King-Herbert A, Thayer K. 2006. NTP workshop: animal models for the NTP rodent cancer bioassay: stocks and strains – should we switch? Toxicol Pathol. 34:802–805.
   PubMed Web of Science ®Google Scholar
• King-Herbert AP, Sills RC, Bucher JR. 2010. Commentary: update on animal models for NTP studies. Toxicol Pathol. 38:180–181.
   PubMed Web of Science ®Google Scholar
• Kivipensas P, Bjorkqvist AM, Karhu R, Pelin K, Linnainmaa K, Tammilehto L, Mattson K, Kallioniemi QP, Knuutila S. 1996. Gains and losses of DNA sequences in malignant mesothelioma by comparative genomic hybridization. Cancer Genet Cytogenet. 89:7–13.
   PubMedGoogle Scholar
• Kodell RL, Blackwell BN, Bucci TJ, Greenman DL. 1995. Cause-of-death assignment at the National Center for Toxicological Research. Toxicol Pathol. 23:241–247.
   PubMed Web of Science ®Google Scholar
• Kusewitt D, Hahn F, Pickerell J. 1982. Hematologic and serum chemical characteristics of mononuclear leukemia in Fischer 344 rats. Lab Anim Sci. 32:275–277.
   PubMedGoogle Scholar
• Lafferty JS, Kamendulis LM, Kaster J, Jiang J, Klaunig JE. 2004. Subchronic acrylamide treatment induces a tissue-specific increase in DNA synthesis in the rat. Toxicol Lett. 154:95–103.
   PubMed Web of Science ®Google Scholar
• Lagana SM, Taub RN, Borczuk AC. 2012. Utility of glucose transporter 1 in the distinction of benign and malignant thoracic and abdominal mesothelial lesions. Arch Pathol Lab Med. 136:804–809.
   PubMed Web of Science ®Google Scholar
• Le Cornet C, Lortet-Tieulent J, Forman D, Béranger R, Flechon A, Fervers B, Schüz J, Bray F. 2014. Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data. Eur J Cancer. 50:831–839.
   PubMed Web of Science ®Google Scholar
• Lee AF, Gown AM, Churg A. 2013. IMP3 and GLUT-1 immunohistochemistry for distinguishing benign from malignant mesothelial proliferations. Am J Surg Pathol. 37:421–426.
   PubMed Web of Science ®Google Scholar
• Lee S, Illei PB, Han JS, Epstein JI. 2014. Florid mesothelial hyperplasia of the tunica vaginalis mimicking malignant mesothelioma: a clinicopathologic study of 12 cases. Am J Surg Pathol. 38:54–59.
   PubMed Web of Science ®Google Scholar
• Libé R, Fratticci A, Lahlou N, Jornayvaz FR, Tissier F, Louiset E, Guibourdenche J, Vieillefond A, Zerbib M, Bertherat J. 2012. A rare cause of hypertestosteronemia in a 68-year-old patient: a Leydig cell tumor due to a somatic GNAS (guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1)-activating mutation. J Androl. 33:578–584.
   PubMedGoogle Scholar
• Lindsey J. 1979. Historical foundations. In: Baker H, Lindsey J, Weisbroth S, editors. The laboratory rat. Vol. 1. Biology and diseases. New York: Academic Press. p. 2–33.
   Google Scholar
• Lington AW, Bird MG, Plutnick RT, Stubblefield WA, Scala RA. 1997. Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats. Fundam Appl Toxicol. 36:79–89.
   PubMedGoogle Scholar
• Lipman RD, Dallal GE, Bronson RT. 1999. Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats. J Gerontol A Biol Sci Med Sci. 54:B478–B491.
   Google Scholar
• Losco PE, Ward JM. 1984. The early stage of large granular lymphocyte leukemia in the F344 rat. Vet Pathol. 21:286–291.
   PubMed Web of Science ®Google Scholar
• Maizlin ZV, Belenky A, Kunichezky M, Sandbank J, Strauss S. 2004. Leydig cell tumors of the testis: gray scale and color Doppler sonographic appearance. J Ultrasound Med. 23:959–964.
   PubMed Web of Science ®Google Scholar
• Maqdasy S, Bogenmann L, Batisse-Lignier M, Roche B, Franck F, Desbiez F, Tauveron I. 2015. Leydig cell tumor in a patient with 49,XXXXY karyotype: a review of literature. Reprod Biol Endocrinol. 13:72.
   PubMed Web of Science ®Google Scholar
• Marinaccio A, Binazzi A, Di Marzio D, Scarselli A, Verardo M, Mirabelli D, Gennaro V, Mensi C, Merler E, De Zotti R, et al. 2010. Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register. Occup Environ Med. 67:760–765.
   PubMed Web of Science ®Google Scholar
• Maronpot RR, Flake G, Huff J. 2004. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol. 32:40–48.
   PubMedGoogle Scholar
• Maronpot RR, Thoolen RJ, Hansen B. 2015. Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure. Exp Toxicol Pathol. 67:189–195.
   PubMed Web of Science ®Google Scholar
• Maronpot RR, Zeiger E, McConnell EE, Kolenda-Roberts H, Wall H, Friedman MA. 2009. Induction of tunica vaginalis mesotheliomas in rats by xenobiotics. Crit Rev Toxicol. 39:512–537.
   PubMed Web of Science ®Google Scholar
• Masoudi JF, Van Arsdalen K, Rovner ES. 1999. Organ-sparing surgery for bilateral leydig cell tumor of the testis. Urology. 54:744.
   PubMedGoogle Scholar
• Mensi C, Pellegatta M, Sieno C, Consonni D, Riboldi L, Bertazzi PA. 2012. Mesothelioma of tunica vaginalis testis and asbestos exposure. BJU Int. 110:533–537.
   PubMed Web of Science ®Google Scholar
• Moloney WC, Boschetti AE, King V. 1969. Observations on leukemia in Wistar Furth rats. Cancer Res. 29:938–946.
   PubMed Web of Science ®Google Scholar
• Moloney WC, Boschetti AE, King VP. 1970. Spontaneous leukemia in Fischer rats. Cancer Res. 30:41–43.
   PubMed Web of Science ®Google Scholar
• Moloney WC, King VP. 1973. Reduction of leukemia incidence following splenectomy in the rat. Cancer Res. 33:573–574.
   PubMed Web of Science ®Google Scholar
• Morris JE, Sasser LB, Miller DL, Dagle GE, Rafferty CN, Ebi KL, Anderson LE. 1999. Clinical progression of transplanted large granular lymphocytic leukemia in Fischer 344 rats exposed to 60 Hz magnetic fields. Bioelectromagnetics. 20:48–56.
   PubMed Web of Science ®Google Scholar
• Nolte T, Rittinghausen S, Kellner R, Karbe E, Kittel B, Rinke M, Deschl U. 2011. RITA-Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats. Exp Toxicol Pathol. 63:645–656.
   PubMed Web of Science ®Google Scholar
• Nyska A, Hester SD, Cooper RL, Goldman JM, Stoker TE, House D, Wolf DC. 2002. Single or group housing altered hormonal physiology and affected pituitary and interstitial cell kinetics. J Toxicol Sci. 27:449–457.
   PubMedGoogle Scholar
• Nyska A, Leininger JR, Maronpot RR, Haseman JK, Hailey JR. 1998. Effect of individual versus group caging on the incidence of pituitary and Leydig cell tumors in F344 rats: proposed mechanism. Med Hypotheses. 50:525–529.
   PubMed Web of Science ®Google Scholar
• Ohshima K, Suzumiya J, Kanda M, Kato A, Kikuchi M. 1998. Integrated and episomal forms of Epstein-Barr virus (EBV) in EBV associated disease. Cancer Lett. 122:43–50.
   PubMed Web of Science ®Google Scholar
• Ozyavuz R, Ozen HA, Gedikoglu G, Ozgu IH, Sahin A, Tekgul S, Remzi D. 1993. Leydig cell tumour of the testis: presentation of two cases. Int Urol Nephrol. 25:385–388.
   PubMedGoogle Scholar
• Pacheco AJ, Torres JL, de la Guardia FV, Arrabal Polo MA, Gomez AZ. 2009. Intraparenchymatous adenomatoid tumor dependent on the rete testis: a case report and review of literature. Indian J Urol. 25:126–128.
   PubMedGoogle Scholar
• Peterson JT, Jr, Greenberg SD, Buffler PA. 1984. Non-asbestos-related malignant mesothelioma. A review. Cancer. 54:951–960.
   PubMed Web of Science ®Google Scholar
• Plas E, Riedl CR, Pfluger H. 1998. Malignant mesothelioma of the tunica vaginalis testis: review of the literature and assessment of prognostic parameters. Cancer. 83:2437–2446.
   PubMed Web of Science ®Google Scholar
• Poullot E, Zambello R, Leblanc F, Bareau B, De March E, Roussel M, Boulland ML, Houot R, Renault A, Fest T, et al. 2014. Chronic natural killer lymphoproliferative disorders: characteristics of an international cohort of 70 patients. Ann Oncol. 25:2030–2035.
   PubMed Web of Science ®Google Scholar
• Prentice DE, Siegel RA, Donatsch P, Qureshi S, Ettlin RA. 1992. Mesulergine induced Leydig cell tumours, a syndrome involving the pituitary-testicular axis of the rat. Arch Toxicol Suppl. 15:197–204.
   PubMedGoogle Scholar
• Purdue MP, Devesa SS, Sigurdson AJ, McGlynn KA. 2005. International patterns and trends in testis cancer incidence. Int J Cancer. 115:822–827.
   PubMed Web of Science ®Google Scholar
• Rajan V, Nandhakumar R, Shanmugasundaram S, Ravi R, Natarajan S, Mohan G, Nanjundappan PM. 2013. Paratesticular malignant mesothelioma – a rare case presentation. Indian J Surg. 75:174–176.
   PubMed Web of Science ®Google Scholar
• Rall DP, Hogan MD, Huff JE, Schwetz BA, Tennant RW. 1987. Alternatives to using human experience in assessing health risks. Annu Rev Public Health. 8:355–385.
   PubMed Web of Science ®Google Scholar
• Rao G, Boorman G. 1990. History of the F344 rat. In: Boorman G, Eustis S, Elwell M, Montgomery C, Jr, MacKenzie W, editors. Pathology of the Fischer rat. Reference and Atlas. New York: Academic Press. p. 5–8.
   Google Scholar
• Rao GN, Haseman JK. 1993. Influence of corn oil and diet on body weight, survival, and tumor incidences in F344/N rats. Nutr Cancer. 19:21–30.
   PubMed Web of Science ®Google Scholar
• Rao GN, Haseman JK, Grumbein S, Crawford DD, Eustis SL. 1990. Growth, body weight, survival, and tumor trends in F344/N rats during an eleven-year period. Toxicol Pathol. 18:61–70.
   PubMed Web of Science ®Google Scholar
• Reynolds CW. 1985. Large granular lymphocyte (LGL) lymphoproliferative diseases: naturally cytotoxic tumors in man and experimental animals. Crit Rev Oncol Hematol. 2:185–208.
   PubMed Web of Science ®Google Scholar
• Reynolds CW, Bere EW, Jr, Ward JM. 1984. Natural killer activity in the rat. III. Characterization of transplantable large granular lymphocyte (LGL) leukemias in the F344 rat. J Immunol. 132:534–540.
   PubMed Web of Science ®Google Scholar
• Reynolds CW, Bonyhadi M, Herberman RB, Young HA, Hedrick SM. 1985. Lack of gene rearrangement and mRNA expression of the beta chain of the T cell receptor in spontaneous rat large granular lymphocyte leukemia lines. J Exp Med. 161:1249–1254.
   PubMed Web of Science ®Google Scholar
• Ruskova A, Thula R, Chan G. 2004. Aggressive natural killer-cell leukemia: report of five cases and review of the literature. Leuk Lymphoma. 45:2427–2439.
   PubMed Web of Science ®Google Scholar
• Ryder J, Wang X, Bao L, Gross SA, Hua F, Irons RD. 2007. Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature. Int J Hematol. 85:18–25.
   PubMed Web of Science ®Google Scholar
• Sacksteder MR. 1976. Occurrence of spontaneous tumors in the germfree F344 rat. J Natl Cancer Inst. 57:1371–1373.
   PubMedGoogle Scholar
• Sass B, Rabstein LS, Madison R, Nims RM, Peters RL, Kelloff GJ. 1975. Incidence of spontaneous neoplasms in F344 rats throughout the natural life-span. J Natl Cancer Inst. 54:1449–1456.
   PubMedGoogle Scholar
• Sasser LB, Morris JE, Miller DL, Rafferty CN, Ebi KL, Anderson LE. 1996. Exposure to 60 Hz magnetic fields does not alter clinical progression of LGL leukemia in Fischer rats. Carcinogenesis. 17:2681–2687.
   PubMed Web of Science ®Google Scholar
• Schurkes C, Brock W, Abel J, Unfried K. 2004. Induction of 8-hydroxydeoxyguanosine by man-made vitreous fibres and crocidolite asbestos administered intraperitoneally in rats. Mutat Res. 553:59–65.
   PubMed Web of Science ®Google Scholar
• Segura-Gonzalez M, Urias-Rocha J, Castelan-Pedraza J. 2015. Malignant mesothelioma of the tunica vaginalis: a rare neoplasm-case report and literature review. Clin Genitourin Cancer. 13:e401–e405.
   PubMedGoogle Scholar
• Semenzato G, Marino F, Zambello R. 2012. State of the art in natural killer cell malignancies. Int J Lab Hematol. 34:117–128.
   PubMed Web of Science ®Google Scholar
• Sharpe RM, McNeilly AS. 1979. The effect of induced hyperprolactinaemia on Leydig cell function and LH-induced loss of LH-receptors in the rat testis. Mol Cell Endocrinol. 16:19–27.
   PubMed Web of Science ®Google Scholar
• Shiga A, Narama I. 2015. Hepatic lesions caused by large granular lymphocyte leukemia in Fischer 344 rats: similar morphologic features and morphogenesis to those of nodular regenerative hyperplasia (NRH) in the human liver. Toxicol Pathol. 43:852–864.
   PubMed Web of Science ®Google Scholar
• Shimokawa I, Yu BP, Higami Y, Ikeda T, Masoro EJ. 1993. Dietary restriction retards onset but not progression of leukemia in male F344 rats. J Gerontol. 48:B68–B73.
   Google Scholar
• Shipp A, Lawrence G, Gentry R, McDonald T, Bartow H, Bounds J, Macdonald N, Clewell H, Allen B, Van Landingham C. 2006. Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit Rev Toxicol. 36:481–608.
   PubMed Web of Science ®Google Scholar
• Skakkebaek NE, Holm M, Hoei-Hansen C, Jorgensen N, Rajpert-De Meyts E. 2003. Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from 20 adult patients with signs of maldevelopment of the testis. APMIS. 111:1–9. discussion 9–11.
   PubMed Web of Science ®Google Scholar
• Sokol L, Loughran TP, Jr. 2006. Large granular lymphocyte leukemia. Oncologist. 11:263–273.
   PubMed Web of Science ®Google Scholar
• Song SY, Kim WS, Ko YH, Kim K, Lee MH, Park K. 2002. Aggressive natural killer cell leukemia: clinical features and treatment outcome. Haematologica. 87:1343–1345.
   PubMed Web of Science ®Google Scholar
• Stefanski S, Elwell M, Stromberg P. 1990. Spleen, lymph nodes, and thymus. In: Boorman G, Eustis S, Elwell M, Montgomery C, Jr, MacKenzie W, editors. Pathology of the Fischer rat. Reference and Atlas.New York: Academic Press. p. 369–394.
   Google Scholar
• Stefanski SA, Greenwell A, Merrick BA, Brown TT, Reynolds SH. 1995. Proliferating cell nuclear antigen staining of Fischer-344/N rat spleens affected by large granular lymphocyte leukemia. Toxicol Pathol. 23:1–6.
   PubMed Web of Science ®Google Scholar
• Steinbach T, Maronpot R, Hardisty J. 2015. Human relevance of rodent Leydig cell tumors. In: Harbison R, Bourgeois M, Johnson G, editors. Hamilton & Hardy's industrial toxicology. New York: John Wiley & Sons. p. 1189–1196.
   Google Scholar
• Steinway SN, LeBlanc F, Loughran TP. 2014. The pathogenesis and treatment of large granular lymphocyte leukemia. Blood Rev. 28:87–94.
   PubMed Web of Science ®Google Scholar
• Stromberg PC, Grants IS, Kociba GJ, Krakowka GS, Mezza LE. 1990. Serial syngeneic transplantation of large granular lymphocyte leukemia in F344 rats. Vet Pathol. 27:404–410.
   PubMed Web of Science ®Google Scholar
• Stromberg PC, Rojko JL, Vogtsberger LM, Cheney C, Berman R. 1983d. Immunologic, biochemical, and ultrastructural characterization of the leukemia cell in F344 rats. J Natl Cancer Inst. 71:173–181.
   PubMedGoogle Scholar
• Stromberg PC, Vogtsberger LM. 1983a. Pathology of the mononuclear cell leukemia of Fischer rats. I. Morphologic studies. Vet Pathol. 20:698–708.
   PubMed Web of Science ®Google Scholar
• Stromberg PC, Vogtsberger LM, Marsh LR. 1983c. Pathology of the mononuclear cell leukemia of Fischer rats. III. Clinical chemistry. Vet Pathol. 20:718–726.
   PubMed Web of Science ®Google Scholar
• Stromberg PC, Vogtsberger LM, Marsh LR, Wilson FD. 1983b. Pathology of the mononuclear cell leukemia of Fischer rats. II. Hematology. Vet Pathol. 20:709–717.
   PubMed Web of Science ®Google Scholar
• Stromberg PC, Vogtsberger LM, McMurray DN, Marsh LR, Kotur MS, Brown CA. 1985. Behavior of transplanted large granular lymphocyte leukemia in Fischer 344 rats. Lab Invest. 53:200–208.
   PubMed Web of Science ®Google Scholar
• Suzuki R, Suzumiya J, Nakamura S, Aoki S, Notoya A, Ozaki S, Gondo H, Hino N, Mori H, Sugimori H, et al. 2004. Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells. Leukemia. 18:763–770.
   PubMed Web of Science ®Google Scholar
• Taheri ZM, Mehrafza M, Mohammadi F, Khoddami M, Bahadori M, Masjedi MR. 2008. The diagnostic value of Ki-67 and repp86 in distinguishing between benign and malignant mesothelial proliferations. Arch Pathol Lab Med. 132:694–697.
   PubMed Web of Science ®Google Scholar
• Takeda M, Kasai T, Enomoto Y, Takano M, Morita K, Kadota E, Iizuka N, Maruyama H, Nonomura A. 2012. Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues. J Clin Pathol. 65:77–82.
   PubMed Web of Science ®Google Scholar
• Tanigawa H, Onodera H, Maekawa A. 1987. Spontaneous mesotheliomas in Fischer rats – a histological and electron microscopic study. Toxicol Pathol. 15:157–163.
   PubMed Web of Science ®Google Scholar
• Testa JR, Cheung M, Pei J, Below JE, Tan Y, Sementino E, Cox NJ, Dogan AU, Pass HI, Trusa S, et al. 2011. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 43:1022–1025.
   PubMed Web of Science ®Google Scholar
• Thomas J, Haseman JK, Goodman JI, Ward JM, Loughran TP, Jr, Spencer PJ. 2007. A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicol Sci. 99:3–19.
   PubMed Web of Science ®Google Scholar
• Thurman JD, Bucci TJ, Hart RW, Turturro A. 1994. Survival, body weight, and spontaneous neoplasms in ad libitum-fed and food-restricted Fischer-344 rats. Toxicol Pathol. 22:1–9.
   PubMed Web of Science ®Google Scholar
• Tomatis L, Aitio A, Wilbourn J, Shuker L. 1989. Human carcinogens so far identified. Jpn J Cancer Res. 80:795–807.
   PubMedGoogle Scholar
• Trabert B, Zugna D, Richiardi L, McGlynn KA, Akre O. 2013. Congenital malformations and testicular germ cell tumors. Int J Cancer. 133:1900–1904.
   PubMed Web of Science ®Google Scholar
• Triola MF. 2010. Elementary statistics. 11th ed. Boston: Pearson Education.
   Google Scholar
• Tsitouridis I, Maskalidis C, Panagiotidou D, Kariki EP. 2014. Eleven patients with testicular leydig cell tumors: clinical, imaging, and pathologic correlation. J Ultrasound Med. 33:1855–1864.
   PubMed Web of Science ®Google Scholar
• Turek FW, Desjardins C. 1979. Development of Leydig cell tumors and onset of changes in the reproductive and endocrine systems of aging F344 rats. J Natl Cancer Inst. 63:969–975.
   PubMed Web of Science ®Google Scholar
• Turturro A, Blank K, Murasko D, Hart R. 1994. Mechanisms of caloric restriction affecting aging and disease. Ann N Y Acad Sci. 719:159–170.
   PubMed Web of Science ®Google Scholar
• Ulbright TM, Srigley JR, Hatzianastassiou DK, Young RH. 2002. Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. Am J Surg Pathol. 26:1424–1433.
   PubMed Web of Science ®Google Scholar
• Unluer E, Ozcan D, Altin S. 1990. Malignant Leydig cell tumour of the testis: a case report and review of the literature. Int Urol Nephrol. 22:455–460.
   PubMedGoogle Scholar
• Versnel MA, Hagemeijer A, Bouts MJ, van der Kwast TH, Hoogsteden HC. 1988. Expression of c-sis (PDGF B-chain) and PDGF A-chain genes in ten human malignant mesothelioma cell lines derived from primary and metastatic tumors. Oncogene. 2:601–605.
   PubMed Web of Science ®Google Scholar
• Vukina J, Chism DD, Sharpless JL, Raynor MC, Milowsky MI, Funkhouser WK. 2015. Metachronous bilateral testicular Leydig-like tumors leading to the diagnosis of congenital adrenal hyperplasia (adrenogenital syndrome). Case Rep Pathol. 2015:459318.
   PubMedGoogle Scholar
• Ward J, Rehm S, Reynolds C. 1990. Tumours of the hematopoietic system. In: Turusov V, Mohr U, editors. Pathology of tumours in laboratory animals. Vol. 1. Tumours of the rat. Lyon: International Agency for Research on Cancer. p. 625–657.
   Google Scholar
• Ward JM, Reynolds CW. 1983. Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats. Am J Pathol. 111:1–10.
   PubMed Web of Science ®Google Scholar
• Weisburger EK. 1983. History of the bioassay program of the National Cancer Institute. Prog Exp Tumor Res. 26:187–201.
   PubMed Web of Science ®Google Scholar
• Weisburger JH, Rivenson A, Reinhardt J, Braley J, Pittman B, Zang E. 2002. On the occurrence of Leydig cell tumors in the F344 rat. Cancer Lett. 182:213–216.
   PubMed Web of Science ®Google Scholar
• Winstanley AM, Landon G, Berney D, Minhas S, Fisher C, Parkinson MC. 2006. The immunohistochemical profile of malignant mesotheliomas of the tunica vaginalis: a study of 20 cases. Am J Surg Pathol. 30:1–6.
   PubMed Web of Science ®Google Scholar
• Woodward PJ, Schwab CM, Sesterhenn IA. 2003. From the archives of the AFIP: extratesticular scrotal masses: radiologic-pathologic correlation. Radiographics. 23:215–240.
   PubMed Web of Science ®Google Scholar
• Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE. 2002. From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation. Radiographics. 22:189–216.
   PubMed Web of Science ®Google Scholar
• Xiao SY, Rizzo P, Carbone M. 2000. Benign papillary mesothelioma of the tunica vaginalis testis. Arch Pathol Lab Med. 124:143–147.
   PubMed Web of Science ®Google Scholar
• Yen CH, Lee CT, Su CJ, Lo HC. 2012. Malignant mesothelioma of the tunica vaginalis testis: a malignancy associated with recurrent epididymitis? World J Surg Oncol. 10:238.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Jing W, Ouyang J, Zeng H, George SK, Liu Z. 2014. Six cases of aggressive natural killer-cell leukemia in a Chinese population. Int J Clin Exp Pathol. 7:3423–3431.
   PubMed Web of Science ®Google Scholar