References
- Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DP, et al. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect. 116:1203–1210.
- Allmyr M, Panagiotidis G, Sparve E, Diczfalusy U, Sandborgh-Englund G. 2009. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. Basic Clin Pharmacol Toxicol. 105:339–344.
- Ankley GT, Jensen KM, Kahl MD, Korte JJ, Makynen EA. 2001. Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas). Environ Toxicol Chem. 20:1276–1290.
- Ankley GT, Jensen KM, Kahl MD, Makynen EA, Blake LS, Greene KJ, Johnson RD, Villeneuve DL. 2007. Ketoconazole in the fathead minnow (Pimephales promelas): reproductive toxicity and biological compensation. Env Toxicol Chem. 26:1214–1223.
- Ashby J, Owens W, Deghenghi R, Odum J. 2002. Concept evaluation: an assay for receptor-mediated and biochemical antiestrogens using pubertal rats. Reg Toxicol Pharmacol. 35:393–397.
- Axelstad M, Boberg J, Vinggaard AM, Christiansen S, Hass U. 2013. Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. Food Chem Toxicol. 59: 534–540.
- BASF. 2012. Robust study summary: evaluation of reproductive toxicity to fathead minnow (Pimephales promelas) using 21-d fish reproduction screen (EPA/600/R-01/067) [Internet]. [cited 2015 Dec 18]. In: ECHA 2015, Triclosan REACH dossier. Available from: http://echa.europa.eu/information-on-chemicals/registered-substances.
- Boobis AR, Doe JE, Heinrich-Hirsch B, Meek ME, Muss S, Ruchirawat M, Schlatter J, Seed J, Vickers C. 2008. IPCS framework for analyzing the relevance of a noncancer mode of action for humans. Crit Rev Toxicol. 38:87–96.
- Borgert CJ, Mihaich EM, Ortego LS, Bentley KS, Holmes CM, Levine SL, Becker RA. 2011. Hypothesis-driven weight of evidence framework for evaluating data within the US EPA's Endocrine Disruptor Screening Program. Reg Toxicol Pharmacol. 61:185–191.
- Borgert CJ, Stuchal LD, Mihaich EM, Becker RA, Bentley KS, Brausch JM, Coady K, Geter DR, Gordon E, Guiney PD, et al. 2014. Relevance weighting of tier 1 endocrine screening endpoints by rank order. Birth Defects Res B Dev Reprod Toxicol. 101:90–113.
- Borgert CJ, Becker RA, Carlton BD, Hanson M, Kwiatkowski PL, Marty MS, McCarty LS, Quill TF, Solomon K, Van Der Kraak G, et al. 2016. Does GLP enhance the quality of toxicological evidence for regulatory decisions?. Toxicol Sci. 151:206–213.
- Browne P, Judson RS, Casey W, Kleinstreuer N, Thomas R. 2015. Screening chemicals for estrogen receptor bioactivity using a computational model. Environ Sci Technol. 49:8804–8814.
- Crofton KM, Paul KB, Devito MJ, Hedge JM. 2007. Short-term in vivo exposure to the water contaminant triclosan: evidence for disruption of thyroxine. Environ Toxicol Pharmacol. 24:194–197.
- Cullinan MP, Palmer JE, Carle AD, West MJ, Seymour GJ. 2012. Long term use of triclosan toothpaste and thyroid function. Sci Total Environ. 416:75–79.
- de Peyster A, Mihaich E. 2014. Hypothesis-driven weight of evidence analysis to determine potential endocrine activity of MTBE. Regul Toxicol Pharmacol. 69:348–370.
- DeVito M, Biegel L, Brouwer A, Brown S, Brucker-Davis F, Cheek AO, Christensen R, Colborn T, Cooke P, Crissman J, et al. 1999. Screening methods for thyroid hormone disruptors. Environ Health Perspect. 107:407–415.
- ECHA [Internet]. 2015. Triclosan REACH dossier. [cited 2016 Feb 15]. Available from: http://echa.europa.eu/information-on-chemicals/registered-substances.
- Fang JL, Stingley RL, Beland FA, Harrouk W, Lumpkins DL, Howard P. 2010. Occurrence, efficacy, metabolism, and toxicity of triclosan. J Environ Sci Health, Part C: Environ Carcin Ecotoxicol Rev. 28:147–171.
- Federle TW, Kaiser SK, Nuck BA. 2002. Fate and effects of triclosan in activated sludge. Environ Toxicol Chem. 21:1330–1337.
- Foran CM, Bennett ER, Benson WH. 2000. Developmental evaluation of a potential non- steroidal estrogen: triclosan. Mar Environ Res. 50:153–156.
- Forgacs AL, Ding Q, Jaremba RG, Huhtaniemi IT, Rahman NA, Zacharewski TR. 2012. BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants. Toxicol Sci. 127:391–402.
- Fort DJ, Rogers RL, Gorsuch JW, Navarro LT, Peter R, Plautz JR. 2010. Triclosan and anuran metamorphosis: no effect on thyroid-mediated metamorphosis in Xenopus laevis. Toxicol Sci. 113:392–400.
- Fort DJ, Mathis MB, Hanson W, Fort CE, Navarro LT, Peter R, Buche C, Unger S, Pawlowski S, Plautz JR. 2011. Triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in Xenopus laevis . Toxicol Sci. 121:292–302.
- Gee RH, Charles A, Taylor N, Darbre PD. 2008. Oestrogenic and androgenic activity of triclosan in breast cancer cells. J Appl Toxicol. 28:78–91.
- Goldman JM, Laws SC, Balchak SK, Cooper RL, Kavlock RJ. 2000. Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations. Crit Rev Toxicol. 30:135–196.
- Gosner KL. 1960. A simplified table for staging anuran embryos and larvae with notes on identification. Herpetologica. 16:183–190.
- Greenman J, McKenzie C, Nelson DG. 1997. Effects of triclosan and triclosan monophosphate on maximum specific growth rates, biomass and hydrolytic enzyme production of Streptococcus sanguis and Capnocytophaga gingivalis in continuous culture. J Antimicrob Chemoth. 40:659–666.
- Hinther A, Bromba CM, Wulff JE, Helbing CC. 2011. Effects of triclocarban, triclosan, and methyl triclosan on thyroid hormone action and stress in frog and mammalian culture systems. Environ Sci Technol. 45:5395–5402.
- Honkisz E, Zieba-Przybylska D, Wojtowicz AK. 2012. The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells. Reprod Toxicol. 34:385–392.
- Ishibashi H, Matsumura N, Hirano M, Matsuoka M, Shiratsuchi H, Ishibashi Y, Takao Y, Arizono K. 2004. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat Toxicol. 67:167–179.
- James MO, Marth CJ, Rowland-Faux L. 2012. Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine. Aquat Toxicol. 124–125:72–82.
- Judson RS, Magpantay FM, Chickarmane V, Haskell C, Tania N, Taylor J, Xia M, Huang R, Rotroff DM, Filer DL, et al. 2015. Integrated model of chemical perturbations of a biological pathway using 18 in vitro high-throughput screening assays for the estrogen receptor. Toxicol Sci. 148:137–154.
- Jung EM, An BS, Choi KC, Jeung EB. 2012. Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells. Toxicol Lett. 208:142–148.
- Karmaus AL, Toole CM, Filer DL, Lewis KC, Martin MT. 2016. High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells. Toxicol Sci. 150: 323–332.
- Klimisch HJ, Andreae M, Tillmann U. 1997. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol. 25:1–5.
- Koeppe ES, Ferguson KK, Colacino JA, Meeker JD. 2013. Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008. Sci Total Environ. 445–446:299–305.
- Kumar V, Balomajumder C, Roy P. 2008. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Toxicology. 250:124–131.
- Kumar V, Chakraborty A, Kural MR, Roy P. 2009. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Reprod Toxicol. 27:177–185.
- Laws SC, Yavanhxay S, Cooper RL, Eldridge JC. 2006. Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors. Toxicol Sci. 94:46–56.
- Louis GW, Hallinger DR, Stoker TE. 2013. The effect of triclosan on the uterotrophic response to extended doses of ethinyl estradiol in the weanling rat. Reprod Toxicol. 36:71–77.
- Lynch HN, Goodman JE, Tabony JA, Rhomberg LR. 2016. Systematic comparison of study quality criteria. Regul Toxicol Pharmacol. 76:187–198.
- Marlatt VL, Veldhoen N, Lo BP, Bakker D, Rehaume V, Vallee K, Haberl M, Shang D, van Aggelen GC, Skirrow RC, et al. 2013. Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA). Aquat Toxicol. 126:85–94.
- Marty MS, Crissman JW, Carney EW. 1999. Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor. Toxicol Sci. 52:269–277.
- Marty MS, Crissman JW, Carney EW. 2001. Evaluation of the male pubertal assay's ability to detect thyroid inhibitors and dopaminergic agents. Toxicol Sci. 60:63–76.
- Matsumura N, Ishibashi H, Hirano M, Nagao Y, Watanabe N, Shiratsuchi H, Kai T, Nishimura T, Kashiwagi A, Arizono K. 2005. Effects of nonylphenol and triclosan on production of plasma vitellogenin and testosterone in male South African clawed frogs (Xenopus laevis). Biol Pharm Bull. 28:1748–1751.
- McCarty LS, Borgert CJ, Mihaich EM. 2012. Information quality in regulatory decision making: peer review versus good laboratory practice. Environ Health Perspect. 120:927–934.
- Mitsui N, Tooi O, Kawahara A. 2003. Sandwich ELISAs for quantification of Xenopus laevis vitellogenin and albumin and their application to measurement of estradiol-17 beta effects on whole animals and primary-cultured hepatocytes. Comp Biochem Physiol, Toxicol Pharmacol. 135c:305–313.
- Nieuwkoop PD, Faber J. 1994. Normal table of Xenopus laevis (daudin). New York (NY): Garland Publishing Inc.
- O'Connor JC, Frame SR, Davis LG, Cook JC. 1999. Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure. Toxicol Sci. 51:54–70.
- O’Connor JC, Cook JC, Marty MS, Davis LG, Kaplan AM, Carney EW. 2002. Evaluation of Tier 1 screening approaches for detecting endocrine-active compounds (EACs). Crit Rev Toxicol. 32:521–549.
- OECD. 2004. Detailed review paper on amphibian metamorphosis assay for the detection of thyroid active substances (No. 46). ENV/JM/MONO(2004)17. Paris, France: OECD.
- OECD [Internet]. 2007. OECD 440: Uterotrophic bioassay in rodents: a short-term screening test for oestrogenic properties. [cited 2016 Jan 30]. Available from: http://www.oecd-ilibrary.org/environment/test-no-440-uterotrophic-bioassay-in-rodents_9789264067417-en.
- OECD [Internet]. 2008. OECD 407: Repeated dose 28-day oral toxicity study in rodents. [cited 2016 Feb 4]. Available from: http://www.oecd-ilibrary.org/docserver/download/9740701e.pdf?expires=1466203290&id=id&accname=guest&checksum=09DB9333B32C06647F3E126C9B5A1E93.
- OECD [Internet]. 2009a. OECD 231: The Amphibian Metamorphosis Assay. [cited 2016 Jan 30]. Available from: http://www.oecd-ilibrary.org/environment/test-no-231-amphibian-metamorphosis-assay_9789264076242-en.
- OECD [Internet]. 2009b. OECD 441: Hershberger Bioassay in Rats: A Short-term Screening Assay for Anti(Androgenic) Properties. [cited 2016 Feb 2]. Available from: http://www.oecd-ilibrary.org/environment/test-no-441-hershberger-bioassay-in-rats_9789264076334-en.
- OECD [Internet]. 2011. OECD 456: H295R Steroidogenesis Assay. [cited 2016 Feb 3]. Available at http://www.oecd-ilibrary.org/docserver/download/9745601e.pdf?expires=1477918612&id=id&accname=guest&checksum=9B7463B356CBFE6D9D348CDACCEDF2BE.
- OECD. 2012a. Guidance document on standardised test guidelines for evaluating chemicals for endocrine disruption, Series on Testing and Assessment No. 150. ENV/JM/MONO(2012)22. Paris, France: OECD.
- OECD [Internet]. 2012b. OECD 229: Fish short term reproduction assay. [cited 2016 Jan 20]. Available from: http://www.oecd-ilibrary.org/environment/test-no-229-fish-short-term-reproduction-assay_9789264076211-en.
- OECD. 2014. New scoping document on in vitro and ex vivo assays for the identification of modulators of thyroid hormone signalling, No. 207. ENV/JM/MONO(2014)23. Paris, France: OECD.
- OECD [Internet]. 2016. OECD 458: Stably transfected human androgen receptor transcriptional activation assay for detection of androgenic agonist and antagonist activity of chemicals. [cited 2016 Nov 10]. Available from: http://www.oecd-ilibrary.org/docserver/download/9716131e.pdf?expires=1477907747&id=id&accname=guest&checksum=F96B8209F22062030CF634201CBD65C4
- Paul KB, Hedge JM, DeVito MJ, Crofton KM. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicol Sci. 113:367–379.
- Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. Toxicology. 9300:31–45.
- Pawlowski S, Sauer A, Shears JA, Tyler CR, Braunbeck T. 2004. Androgenic and estrogenic effects of the synthetic androgen 17α-methyltestosterone on sexual development and reproductive performance in the fathead minnow (Pimephales promelas) determined using the gonadal recrudescence assay. Aquat Toxicol. 68:277–291.
- Raut SA, Angus RA. 2010. Triclosan has endocrine-disrupting effects in male western mosquitofish, Gambusia affinis. Environ Toxicol Chem. 29:1287–1291.
- Rhomberg LR, Goodman JE, Bailey LA, Prueitt RL, Beck NB, Bevan C, Honeycutt M, Kaminski NE, Paoli G, Pottenger LH, et al. 2013. A survey of frameworks for best practices in weight-of-evidence analyses. Crit Rev Toxicol. 43:753–784.
- Rodricks JV, Swenberg JA, Borzelleca JF, Maronpot RR, Shipp AM. 2010. Triclosan: a critical review of the experimental data and development of margins of safety for consumer products. Crit Rev Toxicol. 40:422–484.
- Rodriguez PE, Sanchez MS. 2010. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development in Wistar rat offspring. J Toxicol Environ Health A. 73:1678–1688.
- SCCP [Internet]. 2009. Scientific Committee on Consumer Products: Opinion on Triclosan. [cited 2016 Mar 15]. Available from: http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_166.pdf, European Commission.
- SCCS [Internet]. 2011. Scientific Committee on Consumer Safety Opinion on Triclosan: Addendum to the SCCP Opinion on Triclosan (SCCP/1192/08) from January 2009, 22 March 2011. [cited 2016 Mar 15]. Available from: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_054.pdf
- Schneider K, Schwarz M, Burkholder I, Kopp-Schneider A, Edler L, Kinsner-Ovaskainen A, Hartung T, Hoffmann S. 2009. “ToxRTool”, a new tool to assess the reliability of toxicological. Toxicol Lett. 189:138–144.
- Schultz MM, Bartell SE, Schoenfuss HL. 2012. Effects of triclosan and triclocarban, two ubiquitous environmental contaminants, on anatomy, physiology, and behavior of the fathead minnow (Pimephales promelas). Arch Environ Contam Toxicol. 63:114–124.
- Stoker TE, Zorrilla L. 2010. The effects of endocrine disrupting chemicals on pubertal development in the rat. In: Eldridge JC, Stevens JT, editors. Endocrine toxicology. 3rd ed. New York (NY): CRC Press. p. 27–81.
- Stoker TE, Gibson EK, Zorrilla LM. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicol Sci. 117:45–53.
- Stoker TE, Hallinger DR, Louis G. 2014. The effects of triclosan on the male reproductive system of the rat. Poster 1713d Presented at the Society of Toxicology Annual Meeting. Phoenix, AZ.
- Stump DG, O'Connor JC, Lewis JM, Marty MS. 2014. Key lessons from performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 male and female pubertal assays. Birth Defects Res, Part B, Develop Reprod Toxicol. 101:43–62.
- Tyler CR, van Aerle R, Hutchinson TH, Maddix S, Trip H. 1999. An in vivo testing system for endocrine disruptors in fish early life stages using induction of vitellogenin. Environ Toxicol Chem. 18:337–347.
- USEPA [Internet]. 1998. OPPTS 870.3800: reproduction and fertility effects. [cited 2016 Feb 2]. Available from: https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/epa/epa_870_3800.pdf
- USEPA [Internet]. 2002. A short-term test method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas). EPA/600/R-01/067. [cited 2016 Nov 10]. Available from: https://nepis.epa.gov/Exe/tiff2png.cgi/30002HBA.PNG?-r+75+-g+7+D%3A%5CZYFILES%5CINDEX%20DATA%5C00THRU05%5CTIFF%5C00000374%5C30002HBA.TIF.
- USEPA [Internet]. 2007. Integrated summary report for validation of a test method for assessment of pubertal development and thyroid function in juvenile male rats as a potential screen in the endocrine disruptor screening program tier-1 battery. [cited 2016 Feb 20]. Available from: https://www.regulations.gov/document?D=EPA-HQ-OPP-2008-0012-0017.
- USEPA [Internet]. 2009a. OPPTS 890.1100: Amphibian Metamorphosis (Frog). [cited 2016 Jan 30]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009b. OPPTS 890.1150: Androgen Receptor Binding (Rat Prostate Cytosol). [cited 2016 Jan 3]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009c. OPPTS 890.1200: Aromatase (human recombinant) assay. [cited 2016 Jan 3]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009d. OPPTS 890.1250: Estrogen receptor binding assay using rat uterine cytosol (ER-RUC). [cited 2016 Jan 5]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009e. OPPTS 890.1300: Estrogen receptor transcriptional activation (Human Cell Line (HeLa-9903). [cited 2016 Jan 2]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009f. OPPTS 890.1350: Fish short-term reproduction assay. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009g. OPPTS 890.1400: Hershberger bioassay. [cited 2016 Feb 2]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009h. OPPTS 890.1450: Pubertal development and thyroid function in intact juvenile/peripubertal female rats. [cited 2016 Feb 5]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009i. OPPTS 890.1500: Pubertal development and thyroid function in intact juvenile/peripubertal male rats. [cited 2016 Feb 5]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009j. OPPTS 890.1550: Steroidogenesis (Human Cell Line –H295R). [cited 2016 Feb 3]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2009k. OPPTS 890.1600: Uterotrophic assay. EPA 740-C-09-0010. [cited 2016 Jan 30]. Available from: http://www.epa.gov/test-guidelines-pesticides-and-toxic-substances/series-890-endocrine-disruptor-screening-program.
- USEPA [Internet]. 2011. Weight-of-evidence: evaluating results of EDSP tier 1 screening to identify the need for tier 2 testing. [cited 2016 Mar 1]. Available from: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2010-0877-0021.
- USEPA [Internet]. 2013. SAP Review of weight-of-evidence: evaluating results of EDSP Tier 1 Screening. [cited 2016 Nov 10]. Available from: http://www.regulations.gov/#!docketDetail;D=EPA-HQ-OPP-2013-0230.
- USFDA [Internet]. 2015. Guidance for industry. Nonclinical evaluation of endocrine-related drug toxicity. [cited 2016 Mar 10]. Available from: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm369043.pdf.
- Veldhoen N, Skirrow RC, Ji L, Domanski D, Bonfield ER, Bailey CM, Helbing CC. 2006. Use of heterologous cDNA arrays and organ culture in the detection of thyroid hormone- dependent responses in a sentinel frog, Rana catesbeiana. Comp Biochem Physiol Part D: Genom Proteom. 1:187–199.
- Weed DL. 2005. Weight of evidence: a review of concept and methods. Risk Anal. 25:1545–1557.
- WHO/IPSC [Internet]. 2002. Global assessment of the state-of-the-science of endocrine disruptors. World Health Organization publication. WHO/PCS/EDC 02.2. [cited 2016 Jan 3]. Available from: http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en/.
- Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, Cooper RL, Stoker TE. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol Sci. 107:56–64.