Simulated biological fluids – a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres

References

• Abollino O, Giacomino A, Paparella G, Magi E, Conca E, Malandrino M. 2018. Potentially toxic elements in ayurvedic formulations: total and bioaccessible content. Microchem J. 136:236–243.
   Web of Science ®Google Scholar
• Adamcakova-Dodd A, Stebounova LV, Kim J, Vorrink SU, Ault AP, O’Shaughnessy PT, Grassian VH, Thorne PS. 2014. Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models. Part Fibre Toxicol. 11:15.
   PubMed Web of Science ®Google Scholar
• Aladova EE, Romanov SA, Guilmette RA, Khokhryakov VF, Suslova KG. 2007. In vitro dissolution study of plutonium in aerosol particles from the Mayak PA: a tool for individualised dose estimates. Radiat Prot Dosimetry. 127:60–63.
   PubMed Web of Science ®Google Scholar
• Alexander IC, Brown RC, Jubb GA, Pickering P, Hoskins JA. 1994. Durability of ceramic and novel man-made mineral fibers. Environ Health Perspect. 102:67–71.
   PubMed Web of Science ®Google Scholar
• Allen BL, Kichambare PD, Gou P, Vlasova II, Kapralov AA, Konduru N, Kagan VE, Star A. 2008. Biodegradation of single-walled carbon nanotubes through enzymatic catalysis. Nano Lett. 8:3899–3903.
   PubMed Web of Science ®Google Scholar
• Allen BL, Kotchey GP, Chen Y, Yanamala NVK, Klein-Seetharaman J, Kagan VE, Star A. 2009. Mechanistic investigations of horseradish peroxidase-catalyzed degradation of single-walled carbon nanotubes. J Am Chem Soc. 131:17194–17205.
   PubMed Web of Science ®Google Scholar
• Alpofead JAH, Davidson CM, Littlejohn D. 2017. A novel two-step sequential bioaccessibility test for potentially toxic elements in inhaled particulate matter transported into the gastrointestinal tract by mucociliary clearance. Anal Bioanal Chem. 409:3165–3174.
   PubMed Web of Science ®Google Scholar
• Andersen JC, Cropp A, Paradise DC. 2017. Solubility of indium-tin oxide in simulated lung and gastric fluids: pathways for human intake. Sci Total Environ. 579:628–636.
   PubMed Web of Science ®Google Scholar
• Andón FT, Kapralov AA, Yanamala N, Feng W, Baygan A, Chambers BJ, Hultenby K, Ye F, Toprak MS, Brandner BD, et al. 2013. Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase. Small. 9:2721–2729. 2720.
   PubMed Web of Science ®Google Scholar
• Ansoborlo E, Chalabreysse J, Escallon S, Henge-Napoli MH. 1990. In vitro solubility of uranium tetrafluoride with oxidizing medium compared with in vivo solubility in rats. Int J Radiat Biol. 58:681–689.
   PubMed Web of Science ®Google Scholar
• Ansoborlo E, Chalabreysse J, Henge-Napoli MH, Pujol E. 1992. In vitro chemical and cellular tests applied to uranium trioxide with different hydration states. Environ Health Perspect. 97:139–143.
   PubMed Web of Science ®Google Scholar
• Ansoborlo E, Henge-Napoli MH, Chazel V, Gibert R, Guilmette RA. 1999. Review and critical analysis of available in vitro dissolution tests. Health Phys. 77:638–645.
   PubMed Web of Science ®Google Scholar
• Artelt S, Creutzenberg O, Kock H, Levsen K, Nachtigall D, Heinrich U, Ruhle T, Schlogl R. 1999. Bioavailability of fine dispersed platinum as emitted from automotive catalytic converters: a model study. Sci Total Environ. 228:219–242.
   PubMed Web of Science ®Google Scholar
• Artelt S, Kock H, Nachtigall D, Heinrich U. 1998. Bioavailability of platinum emitted from automobile exhaust. Toxicol Lett. 96-97:163–167.
   PubMed Web of Science ®Google Scholar
• Baek M, Kim IS, Yu J, Chung HE, Choy JH, Choi SJ. 2011. Effect of different forms of anionic nanoclays on cytotoxicity. J Nanosci Nanotechnol. 11:1803–1806.
   PubMed Web of Science ®Google Scholar
• Bal W, Sokołowska M, Kurowska E, Faller P. 2013. Binding of transition metal ions to albumin: sites, affinities and rates. Biochim Biophys Acta. 1830:5444–5455.
   PubMed Web of Science ®Google Scholar
• Balakumaran MD, Ramachandran R, Jagadeeswari S, Kalaichelvan PT. 2016. In vitro biological properties and characterization of nanosilver coated cotton fabrics – An application for antimicrobial textile finishing. Int Biodeterior Biodegrad. 107:48–55.
   Web of Science ®Google Scholar
• Bandyopadhyay D, Cyphersmith A, Zapata JA, Kim YJ, Payne CK. 2014. Lysosome transport as a function of lysosome diameter. PLoS One. 9:e86847.
   PubMed Web of Science ®Google Scholar
• Barly SHQ, Okhrimenko DV, Solvang M, Yue Y, Stipp SLS. 2019. Dissolution of stone wool fibers with phenol-urea-formaldehyde binder in a synthetic lung fluid. Chem Res Toxicol. 32:2398–2410.
   PubMed Web of Science ®Google Scholar
• Beeston MP, van Elteren JT, Selih VS, Fairhurst R. 2010. Characterization of artificially generated PbS aerosols and their use within a respiratory bioaccessibility test. Analyst. 135:351–357.
   PubMed Web of Science ®Google Scholar
• Benjaminsen RV, Mattebjerg MA, Henriksen JR, Moghimi SM, Andresen TL. 2013. The Possible “Proton sponge" effect of polyethylenimine (PEI) does not include change in lysosomal pH”. Mol Ther. 21:149–157.
   PubMed Web of Science ®Google Scholar
• Berlinger B, Ellingsen DG, Naray M, Zaray G, Thomassen Y. 2008. A study of the bio-accessibility of welding fumes. J Environ Monit. 10:1448–1453.
   PubMed Web of Science ®Google Scholar
• Berlinger B, Skogen U, Meijer C, Thomassen Y. 2019. Workplace exposure to particulate matter, bio-accessible, and non-soluble metal compounds during hot work processes. J Occup Environ Hyg. 16:378–386.
   PubMed Web of Science ®Google Scholar
• Berlinger B, Weinbruch S, Ellingsen DG, Zibarev E, Chashchin V, Chashchin M, Thomassen Y. 2019. On the bio-accessibility of 14 elements in welding fumes. Environ Sci Process Impacts. 21:497–505.
   PubMed Web of Science ®Google Scholar
• Bernstein DM, Morscheidt C, Grimm HG, Thévenaz P, Teichert U. 1996. Evaluation of soluble fibers using the inhalation biopersistence model, a nine-fiber comparison. Inhalation Toxicol. 8:345–385.
   Web of Science ®Google Scholar
• Bertoli F, Davies GL, Monopoli MP, Moloney M, Gun'ko YK, Salvati A, Dawson KA. 2014. Magnetic nanoparticles to recover cellular organelles and study the time resolved nanoparticle-cell interactome throughout uptake. Small. 10:3307–3315.
   PubMed Web of Science ®Google Scholar
• Bicer EM. 2015. Compositional characterisation of human respiratory tract lining fluids for the design of disease specific simulants. London (UK): King’s College London.
   Google Scholar
• Bidani A, Brown SE, Heming TA, Gurich R, TD, Dubose J. 1989. Cytoplasmic pH in pulmonary macrophages: recovery from acid load is Na + independent and NEM sensitive. Am J Physiol. 257:C65–C76.
   PubMed Web of Science ®Google Scholar
• Birmili W, Allen AG, Bary F, Harrison RM. 2006. Trace metal concentrations and water solubility in size-fractionated atmospheric particles and influence of road traffic. Environ Sci Technol. 40:1144–1153.
   PubMed Web of Science ®Google Scholar
• Bodem CR, Lampton LM, Miller DP, Tarka EF, Everett ED. ED. 1983. Endobronchial pH. Am Rev Respir Dis. 127:39–41.
   PubMedGoogle Scholar
• Bohner M, Lemaitre J. 2009. Can bioactivity be tested in vitro with SBF solution? Biomaterials. 30:2175–2179.
   PubMed Web of Science ®Google Scholar
• Boisa N, Elom N, Dean JR, Deary ME, Bird G, Entwistle JA. 2014. Development and application of an inhalation bioaccessibility method (IBM) for lead in the PM10 size fraction of soil. Environ Int. 70:132–142.
   PubMed Web of Science ®Google Scholar
• Bourliva A, Papadopoulou L, da Silva EF, Patinha C. 2020. In vitro assessment of oral and respiratory bioaccesibility of trace elements of environmental concern in Greek fly ashes: assessing health risk via ingestion and inhalation. Sci Total Environ. 704:135324.
   PubMed Web of Science ®Google Scholar
• Boyles MSP, Brown D, Knox J, Horobin M, Miller MR, Johnston HJ, Stone V. 2018. Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools. Inhal Toxicol. 30:255–272.
   PubMed Web of Science ®Google Scholar
• Boyles MSP, Poland CA, Raftis J, Duffin R. 2019. Assessment of the physicochemical properties of chrysotile-containing brake debris pertaining to toxicity. Inhal Toxicol. 31:325–342.
   PubMed Web of Science ®Google Scholar
• Boyles MSP, Ranninger C, Reischl R, Rurik M, Tessadri R, Kohlbacher O, Duschl A, Huber CG. 2016. Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Part Fibre Toxicol. 13:49.
   PubMed Web of Science ®Google Scholar
• Boyles MSP, Kristl T, Andosch A, Zimmermann M, Tran N, Casals E, Himly M, Puntes V, Huber CG, Lütz-Meindl U, et al. 2015a. Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components. J Nanobiotechnology. 13:84.
   PubMed Web of Science ®Google Scholar
• Boyles MSP, Young L, Brown DM, MacCalman L, Cowie H, Moisala A, Smail F, Smith PJW, Proudfoot L, Windle AH, et al. 2015b. Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicol In Vitro. 29:1513–1528.
   PubMed Web of Science ®Google Scholar
• Breitner EK, Burns KE, Hussain SM, Comfort KK. 2018. Implementation of physiological fluids to provide insight into the characterization, fate, and biological interactions of silver nanoparticles. Nanotechnology. 29:254001.
   PubMed Web of Science ®Google Scholar
• Broadway A, Cave MR, Wragg J, Fordyce FM, Bewley RJ, Graham MC, Ngwenya BT, Farmer JG. 2010. Determination of the bioaccessibility of chromium in Glasgow soil and the implications for human health risk assessment. Sci Total Environ. 409:267–277.
   PubMed Web of Science ®Google Scholar
• Brown AD, Barrett JES, Bennett M, Potgieter-Vermaak S. 2019. An investigation into the use of < 38 microm fraction as a proxy for < 10 microm road dust particles. Environ Geochem Health. 42:1117–1126.
   PubMed Web of Science ®Google Scholar
• Brown RC, Harrison PTC. 2012. Alkaline earth silicate wools – a new generation of high temperature insulation. Regul Toxicol Pharmacol. 64:296–304.
   PubMed Web of Science ®Google Scholar
• Buchman JT, Bennett EA, Wang C, Abbaspour Tamijani A, Bennett JW, Hudson BG, Green CM, Clement PL, Zhi B, Henke AH, et al. 2020. Nickel enrichment of next-generation NMC nanomaterials alters material stability, causing unexpected dissolution behavior and observed toxicity to S. oneidensis MR-1 and D. magna. Environ Sci Nano. 7:571–587.
   Web of Science ®Google Scholar
• Cannizzaro A, Angelosanto F, Barrese E, Campopiano A. 2019. Biosolubility of high temperature insulation wools in simulated lung fluids. J Occup Med Toxicol. 14:15.
   PubMed Web of Science ®Google Scholar
• Cantin AM, Fells GA, Hubbard RC, Crystal RG. 1990. Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract. J Clin Invest. 86:962–971.
   PubMed Web of Science ®Google Scholar
• Cantin AM, North SL, Hubbard RC, Crystal RG. 1987. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol. 63:152–157.
   PubMed Web of Science ®Google Scholar
• Cathe DS, Whitaker JN, Breitner EK, Comfort KK. 2017. Exposure to metal oxide nanoparticles in physiological fluid induced synergistic biological effects in a keratinocyte model. Toxicol Lett. 268:1–7.
   PubMed Web of Science ®Google Scholar
• Chakraborty S, Nair A, Paliwal M, Dybowska A, Misra SK. 2018. Exposure media a critical factor for controlling dissolution of CuO nanoparticles. J Nanopart Res. 20:331.
   Web of Science ®Google Scholar
• Charrier JG, McFall AS, Richards-Henderson NK, Anastasio C. 2014. Hydrogen peroxide formation in a surrogate lung fluid by transition metals and quinones present in particulate matter. Environ Sci Technol. 48:7010–7017.
   PubMed Web of Science ®Google Scholar
• Chazel V, Gerasimo P, Dabouis V, Laroche P, Paquet F. 2003. Characterisation and dissolution of depleted uranium aerosols produced during impacts of kinetic energy penetrators against a tank. Radiat Prot Dosim. 105:163–166.
   PubMed Web of Science ®Google Scholar
• Chazel V, Houpert P, Paquet F, Ansoborlo E, Heng-Napoli MH. 2000. Experimental determination of the solubility of industrial UF4 particulates. Radiat Prot Dosim. 92:289–294.
   Web of Science ®Google Scholar
• Cheng YS, Dahl AR, Jow HN. 1997. Dissolution of metal tritides in a simulated lung fluid. Health Phys. 73:633–638.
   PubMed Web of Science ®Google Scholar
• Cheng YS, Guilmette RA, Zhou Y, Gao J, Labone T, Whicker JJ, Hoover MD. 2004. Characterization of plutonium aerosol collected during an accident. Health Phys. 87:596–605.
   PubMed Web of Science ®Google Scholar
• Cheng YS, Zhou Y, Wang YS, Inkret WC, Wermer JR. 2002. Dose estimate of inhaled hafnium tritide using the ICRP 66 lung model. Health Phys. 82:817–824.
   PubMed Web of Science ®Google Scholar
• Cheyne SE, McClintock LF, Blackman AG. 2006. Stabilization of coordinated carbonate in aqueous acidic solution: steric inhibition of protonation in Co(III) complexes containing chelated carbonate. Inorg Chem. 45:2610–2618.
   PubMed Web of Science ®Google Scholar
• Christensen VR, Jensen SL, Guldberg M, Kamstrup O. 1994. Effect of chemical composition of man-made vitreous fibers on the rate of dissolution in vitro at different pHs. Environ Health Perspect. 102 Suppl 5:83–86.
   PubMed Web of Science ®Google Scholar
• Coakley RD, Grubb BR, Paradiso AM, Gatzy JT, Johnson LG, Kreda SM, Neal WK, Boucher RC. 2003. Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium. Proc Natl Acad Sci U S A. 100:16083–16088.
   PubMed Web of Science ®Google Scholar
• Collier CG, Pearce MJ, Hodgson A, Ball A. 1992. Factors affecting the in vitro dissolution of cobalt oxide. Environ Health Perspect. 97:109–113.
   PubMed Web of Science ®Google Scholar
• Colombo C, Monhemius AJ, Plant JA. 2008. Platinum, palladium and rhodium release from vehicle exhaust catalysts and road dust exposed to simulated lung fluids. Ecotoxicol Environ Saf. 71:722–730.
   PubMed Web of Science ®Google Scholar
• Cooper B, Creeth JM, Donald AS. 1985. Studies of the limited degradation of mucus glycoproteins. The mechanism of the peroxide reaction. Biochem J. 228:615–626.
   PubMed Web of Science ®Google Scholar
• Costabile G, d'Angelo I, Rampioni G, Bondì R, Pompili B, Ascenzioni F, Mitidieri E, d'Emmanuele di Villa Bianca R, Sorrentino R, Miro A, et al. 2015. Toward repositioning niclosamide for antivirulence therapy of Pseudomonas aeruginosa lung infections: development of inhalable formulations through nanosuspension technology. Mol Pharm. 12:2604–2617.
   PubMedGoogle Scholar
• Coufalik P, Matousek T, Krumal K, Vojtisek-Lom M, Beranek V, Mikuska P. 2019. Content of metals in emissions from gasoline, diesel, and alternative mixed biofuels. Environ Sci Pollut Res. 26:29012–29019.
   PubMed Web of Science ®Google Scholar
• Coufalik P, Mikuska P, Matousek T, Vecera Z. 2016. Determination of the bioaccessible fraction of metals in urban aerosol using simulated lung fluids. Atmos Environ. 140:469–475.
   Web of Science ®Google Scholar
• Creuwels LAJM, van Golde LMG, Haagsman HP. 1997. The pulmonary surfactant system: biochemical and clinical aspects. Lung. 175:1–39.
   PubMed Web of Science ®Google Scholar
• Cross CE, van der Vliet A, O'Neill CA, Louie S, Halliwell B. 1994. Oxidants, antioxidants, and respiratory tract lining fluids. Environ Health Perspect. 102:185–191.
   PubMed Web of Science ®Google Scholar
• Cruz N, Rodrigues SM, Tavares D, Monteiro RJ, Carvalho L, Trindade T, Duarte AC, Pereira E, Romkens PF. 2015. Testing single extraction methods and in vitro tests to assess the geochemical reactivity and human bioaccessibility of silver in urban soils amended with silver nanoparticles. Chemosphere. 135:304–311.
   PubMed Web of Science ®Google Scholar
• Cui XY, Xiang P, He RW, Juhasz A, Ma LQ. 2016. Advances in in vitro methods to evaluate oral bioaccessibility of PAHs and PBDEs in environmental matrices. Chemosphere. 150:378–389.
   PubMed Web of Science ®Google Scholar
• da Silva LID, Yokoyama L, Maia LB, Monteiro MIC, Pontes FVM, Carneiro MC, Neto AA. 2015. Evaluation of bioaccessible heavy metal fractions in PM10 from the metropolitan region of Rio de Janeiro city, Brazil, using a simulated lung fluid. Microchem J. 118:266–271.
   Web of Science ®Google Scholar
• Dargaville PA, South M, Vervaart P, McDougall PN. 1999. Validity of markers of dilution in small volume lung lavage. Am J Respir Crit Care Med. 160:778–784.
   PubMed Web of Science ®Google Scholar
• Dartey E, Berlinger B, Thomassen Y, Ellingsen DG, Odland JO, Nartey VK, Yeboah FA, Weinbruch S. 2014. Bioaccessibility of lead in airborne particulates from car battery repair work. Environ Sci Process Impacts. 16:2782–2788.
   PubMed Web of Science ®Google Scholar
• Davies NM, Feddah MR. 2003. A novel method for assessing dissolution of aerosol inhaler products. Int J Pharm. 255:175–187.
   PubMed Web of Science ®Google Scholar
• Dean JR, Elom NI, Entwistle JA. 2017. Use of simulated epithelial lung fluid in assessing the human health risk of Pb in urban street dust. Sci Total Environ. 579:387–395.
   PubMed Web of Science ®Google Scholar
• Deubner DC, Sabey P, Huang W, Fernandez D, Rudd A, Johnson WP, Storrs J, Larson R. 2011. Solubility and chemistry of materials encountered by beryllium mine and ore extraction workers: relation to risk. J Occup Environ Med. 53:1187–1193.
   PubMed Web of Science ®Google Scholar
• Dörger M, Münzing S, Allmeling AM, Messmer K, Krombach F. 2001. Differential Responses of Rat Alveolar and Peritoneal Macrophages to Man-Made Vitreous Fibers in Vitro. Environ Res. 85:207–214.
   PubMed Web of Science ®Google Scholar
• Duranti M, Scarafoni A, Di Cataldo A, Sessa F. 2001. Interaction of metal ions with lupin seed conglutin gamma. Phytochemistry. 56:529–533.
   PubMed Web of Science ®Google Scholar
• EC. 2011. Commision Recommendation of 18 October 2011 on the definition of nanomaterial (Text with EEA relevance) (2011/696/EU). OJ, L 275:38–40.
   Google Scholar
• ECHA. 2016. New approach methodologies in regulatory science: proceedings of a scientific workshop. [accessed April 2020]. https://echa.europa.eu/documents/10162/22816069/scientific_ws_proceedings_en.pdf
   Google Scholar
• Eidson AF. 1994. The effect of solubility on inhaled uranium compound clearance: a review. Health Phys. 67:1–14.
   PubMed Web of Science ®Google Scholar
• Eidson AF, Griffith WC. Jr. 1984. Techniques for yellowcake dissolution studies in vitro and their use in bioassay interpretation. Health Phys. 46:151–163.
   PubMed Web of Science ®Google Scholar
• Eidson AF, Mewhinney JA. 1980. In vitro solubility of yellowcake samples from four uranium mills and the implications for bioassay interpretation. Health Phys. 39:893–902.
   PubMed Web of Science ®Google Scholar
• Ellingsen DG, Chashchin M, Berlinger B, Fedorov V, Chashchin V, Thomassen Y. 2017. Biological monitoring of welders’ exposure to chromium, molybdenum, tungsten and vanadium. J Trace Elem Med Biol. 41:99–106.
   PubMed Web of Science ®Google Scholar
• Ellingsen DG, Zibarev E, Kusraeva Z, Berlinger B, Chashchin M, Bast-Pettersen R, Chashchin V, Thomassen Y. 2013. The bioavailability of manganese in welders in relation to its solubility in welding fumes. Environ Sci Process Impacts. 15:357–365.
   PubMed Web of Science ®Google Scholar
• Fashina A, Antunes E, Nyokong T. 2013. Silica nanoparticles grafted with phthalocyanines: photophysical properties and studies in artificial lysosomal fluid. New J Chem. 37:2800–2809.
   Web of Science ®Google Scholar
• Figueroa-Lara JJ, Murcia-Gonzalez JM, Garcia-Martinez R, Romero-Romo M, Torres RM, Mugica AV. 2019. Effect of platform subway depth on the presence of Airborne PM2.5, metals, and toxic organic species. J Hazard Mater. 377:427–436.
   PubMed Web of Science ®Google Scholar
• Foy JWD, Collier C, Swauger JE. 2003. A comparison of mathematical methods for the determination of in vitro dissolution constants for glass fibers. Inhal Toxicol. 15:167–179.
   PubMed Web of Science ®Google Scholar
• Frohlich E. 2017. Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening. Drug Delivery. 24:891–905.
   PubMed Web of Science ®Google Scholar
• Gamble JL. 1976. Chemical anatomy, physiology and pathology of extracellular fluid: a lecture syllabus. Cambridge (MA): Harvard University Press.
   Google Scholar
• Gao P, Guo H, Wang S, Guo L, Xing Y, Yao C, Jia L, Fan Q, Hang J. 2019. In Vitro investigations of high molecular weight polycyclic aromatic hydrocarbons in winter airborne particles using simulated lung fluids. Atmos Environ. 201:293–300.
   Web of Science ®Google Scholar
• Gao P, Jian H, Xing Y, Tianxing X, Chen X, Jia L, Hang J. 2020. Bioaccessiblity and exposure assessment of PM2.5- and PM10-bound rare earth elements in Oil City, Northeast China. J Hazard Mater. 396:122520.
   PubMed Web of Science ®Google Scholar
• Garger EK, Meisenberg O, Odintsov O, Shynkarenko V, Tschiersch J. 2013. Solubility of hot fuel particles from Chernobyl-influencing parameters for individual radiation dose calculations. Talanta. 115:40–46.
   PubMed Web of Science ®Google Scholar
• Garger EK, Sazhenyuk AD, Odintzov AA, Paretzke HG, Roth P, Tschiersch J. 2004. Solubility of airborne radioactive fuel particles from the Chernobyl reactor and implication to dose. Radiat Environ Biophys. 43:43–49.
   PubMed Web of Science ®Google Scholar
• Giordani M, Cametti G, Di Lorenzo F, Churakov SV. 2019. Real-time observation of fibrous zeolites reactivity in contact with simulated lung fluids (SLFs) obtained by atomic force microscope (AFM). Minerals. 9:83.
   Web of Science ®Google Scholar
• Goerke J. 1998. Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta. 1408:79–89.
   PubMed Web of Science ®Google Scholar
• Gomez MA, Alisaraie L, Shio MT, Berghuis AM, Lebrun C, Gautier-Luneau I, Olivier M. 2010. Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate. J Biol Chem. 285:24620–24628.
   PubMed Web of Science ®Google Scholar
• Gosselin M, Zagury GJ. 2020. Metal(loid)s inhalation bioaccessibility and oxidative potential of particulate matter from chromated copper arsenate (CCA)-contaminated soils. Chemosphere. 238:124557.
   PubMed Web of Science ®Google Scholar
• Gray EP, Browning CL, Wang M, Gion KD, Chao EY, Koski KJ, Kane AB, Hurt RH. 2018. Biodissolution and cellular response to MoO3 nanoribbons and a new framework for early hazard screening for 2D materials. Environ Sci Nano. 5:2545–2559.
   PubMed Web of Science ®Google Scholar
• Gray JE, Plumlee GS, Morman SA, Higueras PL, Crock JG, Lowers HA, Witten ML. 2010. In vitro studies evaluating leaching of mercury from mine waste calcine using simulated human body fluids. Environ Sci Technol. 44:4782–4788.
   PubMed Web of Science ®Google Scholar
• Greenwell LL, Moreno T, Richards RJ. 2003. Pulmonary antioxidants exert differential protective effects against urban and industrial particulate matter. J Biosci. 28:101–107.
   PubMed Web of Science ®Google Scholar
• Griffiths NM, Coudert S, Moureau A, Laroche P, Angulo JF, Van der Meeren A. 2016. Forecasting the in vivo behavior of radiocontaminants of unknown physicochemical properties using a simple in vitro test. Health Phys. 111:93–99.
   PubMed Web of Science ®Google Scholar
• Gualtieri AF, Pollastri S, Bursi Gandolfi N, Gualtieri ML. 2018. In vitro acellular dissolution of mineral fibres: a comparative study. Sci Rep. 8:7071.
   PubMed Web of Science ®Google Scholar
• Guldberg M, Christensen VR, Perander M, Zoitos B, Koenig AR, Sebastian K. 1998. Measurement of in-vitro fibre dissolution rate at acidic pH. Ann Occup Hyg. 42:233–243.
   Web of Science ®Google Scholar
• Guldberg M, Jensen SL, Knudsen T, Steenberg T, Kamstrup O. 2002. High-alumina low-silica HT stone wool fibers: a chemical compositional range with high biosolubility. Regul Toxicol Pharmacol. 35:217–226.
   PubMed Web of Science ®Google Scholar
• Guldberg M, Madsen AL, Sebastian K, Fellman J, Potter R, Bauer J, Searl A, Maquin B, Jubb G. 2003. In-vitro dissolution of vitreous silicate fibres according to EURIMA test guideline – results of two Round Robins. Glass Sci Technol. 76:199–205.
   Google Scholar
• Guldberg M, de Meringo A, Kamstrup O, Furtak H, Rossiter C. 2000. The development of glass and stone wool compositions with increased biosolubility. Regul Toxicol Pharmacol. 32:184–189.
   PubMed Web of Science ®Google Scholar
• Guney M, Bourges CM, Chapuis RP, Zagury GJ. 2017. Lung bioaccessibility of As, Cu, Fe, Mn, Ni, Pb, and Zn in fine fraction (<20mum) from contaminated soils and mine tailings. Sci Total Environ. 579:378–386.
   PubMed Web of Science ®Google Scholar
• Gupta V, Ahsan F. 2011. Influence of PEI as a core modifying agent on PLGA microspheres of PGE₁, a pulmonary selective vasodilator. Int J Pharm. 413:51–62.
   PubMed Web of Science ®Google Scholar
• Hamilton RF, Wu Z, Thakkar M, Holian A, Mitra S. 2018. Modification of nano-silver bioactivity by adsorption on carbon nanotubes and graphene oxide. Inhal Toxicol. 30:429–438.
   PubMed Web of Science ®Google Scholar
• Hampton MB, Kettle AJ, Winterbourn CC. 1998. Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood. 92:3007–3017.
   PubMed Web of Science ®Google Scholar
• Harrington AD, Hylton S, Schoonen MA. 2012. Pyrite-driven reactive oxygen species formation in simulated lung fluid: implications for coal workers’ pneumoconiosis. Environ Geochem Health. 34:527–538.
   PubMed Web of Science ®Google Scholar
• Harris WR, Silberman D. 1983. Time-dependent leaching of coal fly ash by chelating agents. Environ Sci Technol. 17:139–145.
   PubMed Web of Science ®Google Scholar
• Hassoun M, Royall PG, Parry M, Harvey RD, Forbes B. 2018. Design and development of a biorelevant simulated human lung fluid. J Drug Deliv Sci Technol. 47:485–491.
   PubMed Web of Science ®Google Scholar
• Hatch GE. 1992. Comparative biochemistry of airway lining fluid. In: Parent RA, editor. Treatise on Pulmonary Toxicology. Florida: CRC Press; Vol. 1. p. 617–632.
   Google Scholar
• Hedberg Y, Gustafsson J, Karlsson HL, Moller L, Wallinder IO. 2010. Bioaccessibility, bioavailability and toxicity of commercially relevant iron- and chromium-based particles: in vitro studies with an inhalation perspective. Part Fibre Toxicol. 7:23.
   PubMed Web of Science ®Google Scholar
• Hedberg Y, Hedberg J, Liu Y, Wallinder IO. 2011. Complexation- and ligand-induced metal release from 316L particles: importance of particle size and crystallographic structure. Biometals. 24:1099–1114.
   PubMed Web of Science ®Google Scholar
• Heffernan TE, Lodwick JC, Spitz H, Neton J, Soldano M. 2001. Solubility of airborne uranium compounds at the Fernald Environmental Management Project. Health Phys. 80:255–262.
   PubMed Web of Science ®Google Scholar
• Heim KE, Danzeisen R, Verougstraete V, Gaidou F, Brouwers T, Oller AR. 2020. Bioaccessibility of nickel and cobalt in synthetic gastric and lung fluids and its potential use in alloy classification. Regul Toxicol Pharmacol. 110:104549.
   PubMed Web of Science ®Google Scholar
• Heming TA, Bidani A. 1995. Effects of myristate phorbol ester on V-ATPase activity and Na+-H + exchange in alveolar macrophages. J Leukoc Biol. 57:600–608.
   PubMed Web of Science ®Google Scholar
• Henderson RG, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, et al. 2014. Inter-laboratory validation of bioaccessibility testing for metals. Regul Toxicol Pharmacol. 70:170–181.
   PubMed Web of Science ®Google Scholar
• Hermans C, Aly O, Nyberg BI, Peterson C, Bernard A. 1998. Determinants of Clara cell protein (CC16) concentration in serum: a reassessment with two different immunoassays. Clin Chim Acta. 272:101–110.
   PubMed Web of Science ®Google Scholar
• Hernandez-Pellon A, Nischkauer W, Limbeck A, Fernandez-Olmo I. 2018. Metal(loid) bioaccessibility and inhalation risk assessment: a comparison between an urban and an industrial area. Environ Res. 165:140–149.
   PubMed Web of Science ®Google Scholar
• Herting G, Odnevall Wallinder I, Leygraf C. 2006. Factors that influence the release of metals from stainless steels exposed to physiological media. Corros Sci. 48:2120–2132.
   Web of Science ®Google Scholar
• Herting G, Wallinder IO, Leygraf C. 2007. Metal release from various grades of stainless steel exposed to synthetic body fluids. Corros Sci. 49:103–111.
   Web of Science ®Google Scholar
• Herting G, Wallinder IO, Leygraf C. 2008. Metal release rate from AISI 316L stainless steel and pure Fe, Cr and Ni into a synthetic biological medium-a comparison. J Environ Monit. 10:1092–1098.
   PubMedGoogle Scholar
• Hettiarachchi E, Paul S, Cadol D, Frey B, Rubasinghege G. 2019. Mineralogy controlled dissolution of uranium from airborne dust in simulated lung fluids (SLFs) and possible health implications. Environ Sci Technol Lett. 6:62–67.
   PubMed Web of Science ®Google Scholar
• Holmes AM, Lim J, Studier H, Roberts MS. 2016. Varying the morphology of silver nanoparticles results in differential toxicity against micro-organisms, HaCaT keratinocytes and affects skin deposition. Nanotoxicology. 10:1503–1514.
   PubMed Web of Science ®Google Scholar
• Holter JF, Weiland JE, Pacht ER, Gadek JE, Davis WB. 1986. Protein permeability in the adult respiratory distress syndrome. Loss of size selectivity of the alveolar epithelium. J Clin Invest. 78:1513–1522.
   PubMed Web of Science ®Google Scholar
• Hu X, Zhang N, Liu YT. 2019. In vitro ingestion and inhalation bioaccessibility of soilborne lead, cadmium, arsenic and chromium near a chemical industrial park for health risk assessment. Env Pollut Bioavail. 31:316–322.
   Web of Science ®Google Scholar
• Huang X, Betha R, Tan LY, Balasubramanian R. 2016. Risk assessment of bioaccessible trace elements in smoke haze aerosols versus urban aerosols using simulated lung fluids. Atmos Environ. 125:505–511.
   Web of Science ®Google Scholar
• Huang W, Fernandez D, Rudd A, Johnson WP, Deubner D, Sabey P, Storrs J, Larsen R. 2011. Dissolution and nanoparticle generation behavior of Be-associated materials in synthetic lung fluid using inductively coupled plasma mass spectroscopy and flow field-flow fractionation. J Chromatogr A. 1218:4149–4159.
   PubMed Web of Science ®Google Scholar
• Huang H, Jiang Y, Xu X, Cao X. 2018. In vitro bioaccessibility and health risk assessment of heavy metals in atmospheric particulate matters from three different functional areas of Shanghai, China. Sci Total Environ. 610–611:546–554.
   PubMed Web of Science ®Google Scholar
• Huk A, Izak-Nau E, Reidy B, Boyles M, Duschl A, Lynch I, Dušinska M. 2014. Is the toxic potential of nanosilver dependent on its size? Part Fibre Toxicol 11:65.
   Google Scholar
• ICRP. 1994. Human respiratory tract model for radiological protection. ICRP Publication. 66:1–3.
   Google Scholar
• Inkret WC, Schillaci ME, Boyce MK, Cheng YS, Efurd DW, Little TT, Miller G, Musgrave JA, Wermer JR. 2001. Internal dosimetry for inhalation of hafnium tritide aerosols. Radiat Prot Dosimetry. 93:55–60.
   PubMed Web of Science ®Google Scholar
• ISO. 2017. ISO/TR 19057 Nanotechnologies – use and application of acellular in vitro tests and methodologies to assess nanomaterial biodurability.
   Google Scholar
• Jang Y, Owuor D, Waterman JT, White L, Collins B, Sankar J, Gilbert TW, Yun Y. 2014. Effect of mucin and bicarbonate ion on corrosion behavior of AZ31 magnesium alloy for airway stents. Materials. 7:5866–5882.
   PubMed Web of Science ®Google Scholar
• Jayaraman S, Song Y, Verkman AS. 2001a. Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Am J Physiol Cell Physiol. 281:C1504–C1511.
   PubMed Web of Science ®Google Scholar
• Jayaraman S, Song Y, Vetrivel L, Shankar L, Verkman AS. 2001b. Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH. J Clin Invest. 107:317–324.
   PubMed Web of Science ®Google Scholar
• Johansson A, Lundborg M, Skold CM, Lundahl J, Tornling G, Eklund A, Camner P. 1997. Functional, morphological, and phenotypical differences between rat alveolar and interstitial macrophages. Am J Respir Cell Mol Biol. 16:582–588.
   PubMed Web of Science ®Google Scholar
• Johnson NF. 1994. Phagosomal pH and glass fiber dissolution in cultured nasal epithelial cells and alveolar macrophages: a preliminary study. Environ Health Perspect. 102 Suppl 5:97–102.
   PubMed Web of Science ®Google Scholar
• Joris L, Dab I, Quinton PM. 1993. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis. 148:1633–1637.
   PubMedGoogle Scholar
• Jurinski JB, Rimstidt JD. 2001. Biodurability of talc. Am Mineral. 86:392–399.
   Web of Science ®Google Scholar
• Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, Vlasova II, Belikova NA, Yanamala N, Kapralov A, et al. 2010. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol. 5:354–359.
   PubMed Web of Science ®Google Scholar
• Kahn MC, Anderson GJ, Anyan WR, Hall SB. 1995. Phosphatidylcholine molecular species of calf lung surfactant. Am J Physiol. 269:L567–L573.
   PubMedGoogle Scholar
• Kalina M, Blau H, Riklis S, Kravtsov V. 1995. Interaction of surfactant protein A with bacterial lipopolysaccharide may affect some biological functions. Am J Physiol. 268:L144–L151.
   PubMed Web of Science ®Google Scholar
• Kanapilly GM. 1977. Alveolar microenvironment and its relationship to the retention and transport into blood of aerosols deposited in the alveoli. Health Phys. 32:89–100.
   PubMed Web of Science ®Google Scholar
• Karote D, Walker B, Dai HE, Krishnamoorthi R, Voo J, Rajagopalan S. 2013. Chemical warfare agent simulants in Gamble’s fluid: is the fluid toxic? Can it be made safer by inclusion of solid nanocrystalline metal oxides? J Chem. 2013:641620.
   Web of Science ®Google Scholar
• Kastury F, Ritch S, Rasmussen PE, Juhasz AL. 2020. Influence of household smoking habits on inhalation bioaccessibility of trace elements and light rare earth elements in Canadian house dust. Environ Pollut. 262:114132.
   PubMed Web of Science ®Google Scholar
• Kastury F, Smith E, Karna RR, Scheckel KG, Juhasz AL. 2018a. An inhalation-ingestion bioaccessibility assay (IIBA) for the assessment of exposure to metal(loid)s in PM10. Sci Total Environ. 631-632:92–104.
   PubMed Web of Science ®Google Scholar
• Kastury F, Smith E, Karna RR, Scheckel KG, Juhasz AL. 2018b. Methodological factors influencing inhalation bioaccessibility of metal(loid)s in PM2.5 using simulated lung fluid. Environ Pollut. 241:930–937.
   PubMed Web of Science ®Google Scholar
• Keller JG, Peijnenburg W, Werle K, Landsiedel R, Wohlleben W. 2020. Understanding dissolution rates via continuous flow systems with physiologically relevant metal ion saturation in lysosome. Nanomaterials. 10:311.
   Web of Science ®Google Scholar
• Kelly FJ, Mudway IS. 2003. Protein oxidation at the air-lung interface. Amino Acids. 25:375–396.
   PubMed Web of Science ®Google Scholar
• Kim S, Shim JJ, Burgel PR, Ueki IF, Dao-Pick T, Tam DCW, Nadel JA. 2002. IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Am J Physiol Lung Cell Mol Physiol. 283:L67–L75.
   PubMed Web of Science ®Google Scholar
• Kirkham P, Rahman I. 2006. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther. 111:476–494.
   PubMed Web of Science ®Google Scholar
• Knowles MR, Robinson JM, Wood RE, Pue CA, Mentz WM, Wager GC, Gatzy JT, Boucher RC. 1997. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J Clin Invest. 100:2588–2595.
   PubMed Web of Science ®Google Scholar
• Kokubo T, Ito S, Shigematsu M, Sanka S, Yamamuro T. 1987. Fatigue and life-time of bioactive glass-ceramic A-W containing apatite and wollastonite. J Mater Sci. 22:4067–4070.
   Web of Science ®Google Scholar
• Kokubo T, Takadama H. 2006. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 27:2907–2915.
   PubMed Web of Science ®Google Scholar
• Koltermann-Jülly J, Keller JG, Vennemann A, Werle K, Müller P, Ma-Hock L, Landsiedel R, Wiemann M, Wohlleben W. 2018. Abiotic dissolution rates of 24 (nano)forms of 6 substances compared to macrophage-assisted dissolution and in vivo pulmonary clearance: grouping by biodissolution and transformation. NanoImpact. 12:29–41.
   Web of Science ®Google Scholar
• Kotchey GP, Zhao Y, Kagan VE, Star A. 2013. Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo. Adv Drug Deliv Rev. 65:1921–1932.
   PubMed Web of Science ®Google Scholar
• Krawic C, Luczak MW, Zhitkovich A. 2017. Variation in extracellular detoxification is a link to different carcinogenicity among chromates in rodent and human lungs. Chem Res Toxicol. 30:1720–1729.
   PubMed Web of Science ®Google Scholar
• Kreyling WG. 1992. Intracellular particle dissolution in alveolar macrophages. Environ Health Perspect. 97:121–126.
   PubMed Web of Science ®Google Scholar
• Kuang XM, Scott JA, da Rocha GO, Betha R, Price DJ, Russell LM, Cocker DR, Paulson SE. 2017. Hydroxyl radical formation and soluble trace metal content in particulate matter from renewable diesel and ultra low sulfur diesel in at-sea operations of a research vessel. Aerosol Sci Technol. 51:147–158.
   Web of Science ®Google Scholar
• Kumar A, Bicer EM, Morgan AB, Pfeffer PE, Monopoli M, Dawson KA, Eriksson J, Edwards K, Lynham S, Arno M, et al. 2016. Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid. Nanomedicine. 12:1033–1043.
   PubMed Web of Science ®Google Scholar
• Kumar A, Terakosolphan W, Hassoun M, Vandera KK, Novicky A, Harvey R, Royall PG, Bicer EM, Eriksson J, Edwards K, et al. 2017. A biocompatible synthetic lung fluid based on human respiratory tract lining fluid composition. Pharm Res. 34:2454–2465.
   PubMed Web of Science ®Google Scholar
• Lammel G, Kitanovski Z, Kukucka P, Novak J, Arangio AM, Codling GP, Filippi A, Hovorka J, Kuta J, Leoni C, et al. 2020. Oxygenated and nitrated polycyclic aromatic hydrocarbons in ambient air-levels, phase partitioning, mass size distributions, and inhalation bioaccessibility. Environ Sci Technol. 54:2615–2625.
   PubMed Web of Science ®Google Scholar
• Lang CJ, Postle AD, Orgeig S, Possmayer F, Bernhard W, Panda AK, Jürgens KD, Milsom WK, Nag K, Daniels CB. 2005. Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals. Am J Physiol Regul Integr Comp Physiol. 289:R1426–R1439.
   PubMed Web of Science ®Google Scholar
• Latvala S, Hedberg J, Di Bucchianico S, Moller L, Odnevall Wallinder I, Elihn K, Karlsson HL. 2016. Nickel release, ROS generation and toxicity of Ni and NiO micro- and nanoparticles. PLoS One. 11:e0159684.
   PubMed Web of Science ®Google Scholar
• Lecuyer T, Durand MA, Volatron J, Desmau M, Lai-Kuen R, Corvis Y, Seguin J, Wang G, Alloyeau D, Scherman D, et al. 2020. Degradation of ZnGa2O4:Cr3+ luminescent nanoparticles in lysosomal-like medium. Nanoscale. 12:1967–1974.
   PubMed Web of Science ®Google Scholar
• Lee MC, Penland CM, Widdicombe JH, Wine JJ. 1998. Evidence that Calu-3 human airway cells secrete bicarbonate. Am J Physiol. 274:L450–L453.
   PubMedGoogle Scholar
• Lehuede P, deMeringo A, Bernstein DM. 1997. Comparison of the chemical evolution of MMVF following inhalation exposure in rats and acellular in vitro dissolution. Inhalation Toxicol. 9:495–523.
   Web of Science ®Google Scholar
• Leiby KL, Raredon MSB, Niklason LE. 2020. Bioengineering the blood-gas barrier. Compr Physiol. 10:415–452.
   PubMed Web of Science ®Google Scholar
• Leo BF, Chen S, Kyo Y, Herpoldt KL, Terrill NJ, Dunlop IE, McPhail DS, Shaffer MS, Schwander S, Gow A, et al. 2013. The stability of silver nanoparticles in a model of pulmonary surfactant. Environ Sci Technol. 47:11232–11240.
   PubMed Web of Science ®Google Scholar
• Lesniak A, Campbell A, Monopoli MP, Lynch I, Salvati A, Dawson KA. 2010. Serum heat inactivation affects protein corona composition and nanoparticle uptake. Biomaterials. 31–36:9511–9518.
   Google Scholar
• Li X, Gao Y, Zhang M, Zhang Y, Zhou M, Peng L, He A, Zhang X, Yan X, Wang Y, et al. 2020. In vitro lung and gastrointestinal bioaccessibility of potentially toxic metals in Pb-contaminated alkaline urban soil: the role of particle size fractions. Ecotoxicol Environ Saf. 190:110151.
   PubMed Web of Science ®Google Scholar
• Li Y, Juhasz AL, Ma LQ, Cui X. 2019. Inhalation bioaccessibility of PAHs in PM2.5: implications for risk assessment and toxicity prediction. Sci Total Environ. 650:56–64.
   PubMed Web of Science ®Google Scholar
• Liu X, Hurt RH, Kane AB. 2010. Biodurability of single-walled carbon nanotubes depends on surface functionalization. Carbon. 48:1961–1969.
   PubMed Web of Science ®Google Scholar
• Liu XL, Ji R, Shi Y, Wang F, Chen W. 2019. Release of polycyclic aromatic hydrocarbons from biochar fine particles in simulated lung fluids: implications for bioavailability and risks of airborne aromatics. Sci Total Environ. 655:1159–1168.
   PubMed Web of Science ®Google Scholar
• Liu Y, Qi Y, Yin C, Wang S, Zhang S, Xu A, Chen W, Liu S. 2018. Bio-transformation of graphene oxide in lung fluids significantly enhances its photothermal efficacy. Nanotheranostics. 2:222–232.
   PubMedGoogle Scholar
• Lund LG, Aust AE. 1992. Iron mobilization from crocidolite asbestos greatly enhances crocidolite-dependent formation of DNA single-strand breaks in phi X174 RFI DNA. Carcinogenesis. 13:637–642.
   PubMed Web of Science ®Google Scholar
• Lundborg M, Lind B, Camner P. 1984. Ability of rabbit alveolar macrophages to dissolve metals. Exp Lung Res. 7:11–22.
   PubMed Web of Science ®Google Scholar
• Luo X, Zhao Z, Xie J, Luo J, Chen Y, Li H, Jin L. 2019. Pulmonary bioaccessibility of trace metals in PM2.5 from different megacities simulated by lung fluid extraction and DGT method. Chemosphere. 218:915–921.
   PubMed Web of Science ®Google Scholar
• Luoto K, Holopainen M, Karppinen K, Perander M, Savolainen K. 1994. Dissolution of man-made vitreous fibers in rat alveolar macrophage culture and Gamble’s saline solution: influence of different media and chemical composition of the fibers. Environ Health Perspect. 102 Suppl 5:103–107.
   PubMed Web of Science ®Google Scholar
• MacCuspie RI, Allen AJ, Hackley VA. 2011. Dispersion stabilization of silver nanoparticles in synthetic lung fluid studied under in situ conditions. Nanotoxicology. 5:140–156.
   PubMed Web of Science ®Google Scholar
• Marques MRC, Loebenberg R, Almukainzi M. 2011. Simulated biological fluids with possible application in dissolution testing. Dissolution Technol. 18:15–28.
   Web of Science ®Google Scholar
• Menon JU, Ravikumar P, Pise A, Gyawali D, Hsia CC, Nguyen KT. 2014. Polymeric nanoparticles for pulmonary protein and DNA delivery. Acta Biomater. 10:2643–2652.
   PubMed Web of Science ®Google Scholar
• Metzger R, Cole L. 2004. Solubility characterization of airborne uranium from a uranium recycling plant. Health Phys. 87:89–91.
   PubMed Web of Science ®Google Scholar
• Metzger R, Wichers D, Vaselin J, Velasquez P. 1997. Solubility characterization of airborne uranium from an in situ uranium processing plant. Health Phys. 72:418–422.
   PubMed Web of Science ®Google Scholar
• Meza-Figueroa D, Barboza-Flores M, Romero FM, Acosta-Elias M, Hernández-Mendiola E, Maldonado-Escalante F, Pérez-Segura E, González-Grijalva B, Meza-Montenegro M, García-Rico L, et al. 2020. Metal bioaccessibility, particle size distribution and polydispersity of playground dust in synthetic lysosomal fluids. Sci Total Environ. 713:136481.
   PubMed Web of Science ®Google Scholar
• Midander K, Pan J, Wallinder IO, Leygraf C. 2007. Metal release from stainless steel particles in vitro-influence of particle size. J Environ Monit. 9:74–81.
   PubMedGoogle Scholar
• MilosevicAc A, Bourquin J, Burnand D, Lemal P, Crippa F, Monnier CA, Rodriguez-Lorenzo L, Petri-Fink A, Rothen-Rutishauser B. 2019. Artificial lysosomal platform to study nanoparticle long-term stability. Chimia. 73:55–58.
   PubMed Web of Science ®Google Scholar
• Monopoli MP, Walczyk D, Campbell A, Elia G, Lynch I, Baldelli BF, Dawson KA. 2011. Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles. J Am Chem Soc. 133:2525–2534.
   PubMed Web of Science ®Google Scholar
• Morgensen G. 1984. Durability of mineral fibers in various buffer solutions. Riv Stn Sper Vetro. 14:135.
   Google Scholar
• Moss O. 1979. Simulants of lung interstitial fluid. Health Phys. 36:447–448.
   PubMed Web of Science ®Google Scholar
• Mukhtar A, Limbeck A. 2013. Recent developments in assessment of bio-accessible trace metal fractions in airborne particulate matter: a review. Anal Chim Acta. 774:11–25.
   PubMed Web of Science ®Google Scholar
• Mukhtar A, Mohr V, Limbeck A. 2015. The suitability of extraction solutions to assess bioaccessible trace metal fractions in airborne particulate matter: a comparison of common leaching agents. Environ Sci Pollut Res Int. 22:16620–16630.
   PubMed Web of Science ®Google Scholar
• Mulla JAS, Mabrouk M, Choonara YE, Kumar P, Chejara DR, Du Toit LC, Pillay V. 2017. Development of respirable rifampicin-loaded nano-lipomer composites by microemulsion-spray drying for pulmonary delivery. J Drug Delivery Sci Technol. 41:13–19.
   Web of Science ®Google Scholar
• Muller KH, Kulkarni J, Motskin M, Goode A, Winship P, Skepper JN, Ryan MP, Porter AE. 2010. pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution. ACS Nano. 4:6767–6779.
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science. 311:622–627.
   PubMed Web of Science ®Google Scholar
• Ng AW, Bidani A, Heming TA. 2004. Innate host defense of the lung: effects of lung-lining fluid pH. Lung. 182:297–317.
   PubMed Web of Science ®Google Scholar
• Nielson DW, Goerke J, Clements JA. 1981. Alveolar subphase pH in the lungs of anesthetized rabbits. Proc Natl Acad Sci U S A. 78:7119–7123.
   PubMed Web of Science ®Google Scholar
• Nyberg K, Johansson A, Camner P. 1989a. Intraphagosomal pH in alveolar macrophages studied with fluorescein-labeled amorphous silica particles. Exp Lung Res. 15:49–62.
   PubMed Web of Science ®Google Scholar
• Nyberg K, Johansson U, Rundquist I, Camner P. 1989b. Estimation of pH in individual alveolar macrophage phagolysosomes. Exp Lung Res. 15:499–510.
   PubMed Web of Science ®Google Scholar
• Oberdörster G. 1993. Lung dosimetry: pulmonary clearance of inhaled particles. Aerosol Sci Technol. 18:279–289.
   Web of Science ®Google Scholar
• O'Brien P. 2000. Peroxidases. Chem Biol Interact. 129:113–139.
   PubMed Web of Science ®Google Scholar
• OECD. 2018. Assessment of biodurability of nanomaterials and their surface ligands (ENV/JM/MONO(2018)11). Series on the Safety of Manufactured Nanomaterials No. 86. Paris.
   Google Scholar
• OECD. 2020. Guidance document for the testing of dissolution and dispersion stability of nanomaterials and the use of the data for further environmental testing and assessment strategies (ENV/JM/MONO(2020)9). Series of Testing and Assessment No. 318. Paris.
   Google Scholar
• Osmond-McLeod MJ, Poland CA, Murphy F, Waddington L, Morris H, Hawkins SC, Clark S, Aitken R, McCall MJ, Donaldson K. 2011. Durability and inflammogenic impact of carbon nanotubes compared with asbestos fibres. Part Fibre Toxicol. 8:15.
   PubMed Web of Science ®Google Scholar
• Oyane A, Kim HM, Furuya T, Kokubo T, Miyazaki T, Nakamura T. 2003. Preparation and assessment of revised simulated body fluids. J Biomed Mater Res A. 65:188–195.
   PubMedGoogle Scholar
• Pelfrene A, Cave MR, Wragg J, Douay F. 2017. In vitro investigations of human bioaccessibility from reference materials using simulated lung fluids. IJERPH. 14:112.
   Google Scholar
• Pellosi DS, d'Angelo I, Maiolino S, Mitidieri E, Bianca REdV, Sorrentino R, Quaglia F, Ungaro F. 2018. In vitro/in vivo investigation on the potential of Pluronic® mixed micelles for pulmonary drug delivery. Eur J Pharm Biopharm. 130:30–38.
   PubMed Web of Science ®Google Scholar
• Pilcer G, Amighi K. 2010. Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm. 392:1–19.
   PubMed Web of Science ®Google Scholar
• Plumlee GS, Morman SA, Ziegler TL. 2006. The toxicological geochemistry of earth materials: an overview of processes and the interdisciplinary methods used to understand them. Rev Mineral Geochem. 64:5–57.
   Web of Science ®Google Scholar
• Plumlee GS, Ziegler TL. 2003. The medical geochemistry of dusts, soils, and other earth materials. In: Holland HD, Turekian KK, editors. Environmental geochemistry. Amsterdam: Elsevier; Vol. 9. p. 263–310.
   Google Scholar
• Polezer G, Oliveira A, Potgieter-Vermaak S, Godoi AFL, de Souza RAF, Yamamoto CI, Andreoli RV, Medeiros AS, Machado CMD, Dos Santos EO, et al. 2019. The influence that different urban development models has on PM2.5 elemental and bioaccessible profiles. Sci Rep. 9:14846.
   PubMed Web of Science ®Google Scholar
• Qi Y, Liu Y, Xia T, Xu A, Liu S, Chen W. 2018. The biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and bioactivities toward immune cells. NPG Asia Mater. 10:385–396.
   Web of Science ®Google Scholar
• Radivojev S, Zellnitz S, Paudel A, Fröhlich E. 2019. Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs. Int J Pharm. 556:45–56.
   PubMedGoogle Scholar
• Raesch SS, Tenzer S, Storck W, Rurainski A, Selzer D, Ruge CA, Perez-Gil J, Schaefer UF, Lehr CM. 2015. Proteomic and lipidomic analysis of nanoparticle corona upon contact with lung surfactant reveals differences in protein, but not lipid composition. ACS Nano. 9:11872–11885.
   PubMed Web of Science ®Google Scholar
• Ramos ME, Cappelli C, Rozalen M, Fiore S, Huertas F. 2011. Effect of lactate, glycine, and citrate on the kinetics of montmorillonite dissolution. Am Mineral. 96:768–780.
   Web of Science ®Google Scholar
• Reif RH. 1994. Evaluation of in vitro dissolution rates of thorium in uranium mill tailings. Health Phys. 67:545–547.
   PubMed Web of Science ®Google Scholar
• Rennard SI, Ghafouri M, Thompson AB, Under J, Vaughan W, Jones K, Ertl RF, Christensen K, Prince A, Stahl MG, et al. 1990. Fractional processing of sequential bronchoalveolar lavage to separate bronchial and alveolar samples. Am Rev Respir Dis. 141:208–217.
   PubMed Web of Science ®Google Scholar
• Rozalen M, Ramos ME, Huertas FJ, Fiore S, Gervilla F. 2013. Dissolution kinetics and biodurability of tremolite particles in mimicked lung fluids: Effect of citrate and oxalate. J Asian Earth Sci. 77:318–326.
   Web of Science ®Google Scholar
• Schmaljohann D. 2006. Thermo- and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev. 58:1655–1670.
   PubMed Web of Science ®Google Scholar
• Searl A, Cullen RT. 1997. An enzymatic tissue digestion method for fibre biopersistence studies. Ann Occup Hyg. 41:721–723.
   PubMedGoogle Scholar
• Sebastian K, Fellman J, Potter R, Bauer J, Manville J, Searl A, Meringo A, Maquin B, de Reydellet A, Jubb G, et al. 2002. EURIMA test guideline: In-vitro acellular dissolution of man-made vitreous silicate fibres. Glass Sci Technol. 75:263–270.
   Google Scholar
• Semisch A, Ohle J, Witt B, Hartwig A. 2014. Cytotoxicity and genotoxicity of nano - and microparticulate copper oxide: role of solubility and intracellular bioavailability. Part Fibre Toxicol. 11:10.
   PubMed Web of Science ®Google Scholar
• Serrano AG, Pérez-Gil J. 2006. Protein-lipid interactions and surface activity in the pulmonary surfactant system. Chem Phys Lipids. 141:105–118.
   PubMed Web of Science ®Google Scholar
• Shinohara N, Zhang G, Oshima Y, Kobayashi T, Imatanaka N, Nakai M, Sasaki T, Kawaguchi K, Gamo M. 2017. Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats. Part Fibre Toxicol. 14:48.
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kapralov AA, Feng WH, Kisin ER, Murray AR, Mercer RR, St Croix CM, Lang MA, Watkins SC, Konduru NV, et al. 2012. Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One. 7:e30923.
   PubMed Web of Science ®Google Scholar
• Sigg L, Lindauer U. 2015. Silver nanoparticle dissolution in the presence of ligands and of hydrogen peroxide. Environ Pollut. 206:582–587.
   PubMed Web of Science ®Google Scholar
• Slade R, Crissman K, Norwood J, Hatch G. 1993. Comparison of antioxidant substances in bronchoalveolar lavage cells and fluid from humans, guinea pigs, and rats. Exp Lung Res. 19:469–484.
   PubMed Web of Science ®Google Scholar
• Sleigh MA, Blake JR, Liron N. 1988. The propulsion of mucus by cilia. Am Rev Respir Dis. 137:726–741.
   PubMed Web of Science ®Google Scholar
• Son YJ, McConville JT. 2009. Development of a standardized dissolution test method for inhaled pharmaceutical formulations. Int J Pharm. 382:15–22.
   PubMed Web of Science ®Google Scholar
• Sosnowski TR. 2018. Particles on the lung surface – physicochemical and hydrodynamic effects. Curr Opin Colloid Interface Sci. 36:1–9.
   Web of Science ®Google Scholar
• Spitler G, Spitz H, Glasser S, Hoffman MK, Bowen J. 2015. In vitro dissolution of uranium-contaminated soil in simulated lung fluid containing a pulmonary surfactant. Health Phys. 108:336–343.
   PubMed Web of Science ®Google Scholar
• Stebounova LV, Gonzalez-Pech NI, Peters TM, Grassian VH. 2018. Physicochemical properties of air discharge-generated manganese oxide nanoparticles: Comparison to welding fumes. Environ Sci Nano. 2018:696–707.
   PubMedGoogle Scholar
• Steenberg T, Hjenner HK, Jensen SL, Guldberg M, Knudsen T. 2001. Dissolution behaviour of biosoluble HT stone wool fibres. Glass Sci Technol. 74:97–105.
   Google Scholar
• Stefaniak AB. 2010. Persistence of tungsten oxide particle/fiber mixtures in artificial human lung fluids. Part Fibre Toxicol. 7:38.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Guilmette RA, Day GA, Hoover MD, Breysse PN, Scripsick RC. 2005. Characterization of phagolysosomal simulant fluid for study of beryllium aerosol particle dissolution. Toxicol In Vitro. 19:123–134.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Harvey CJ. 2006. Dissolution of materials in artificial skin surface film liquids. Toxicol In Vitro. 20:1265–1283.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Harvey CJ, Bukowski VC, Leonard SS. 2010. Comparison of free radical generation by pre- and post-sintered cemented carbide particles. J Occup Environ Hyg. 7:23–34.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Leonard SS, Hoover MD, Virji MA, Day GA. 2009. Dissolution and reactive oxygen species generation of inhaled cemented tungsten carbide particles in artificial human lung fluids. J Phys Conf Ser. 151:012045.
   Google Scholar
• Stefaniak AB, Seehra MS, Fix NR, Leonard SS. 2014. Lung biodurability and free radical production of cellulose nanomaterials. Inhalation Toxicol. 26:733–749.
   PubMed Web of Science ®Google Scholar
• Stefaniak AB, Virji MA, Day GA. 2011. Dissolution of beryllium in artificial lung alveolar macrophage phagolysosomal fluid. Chemosphere. 83:1181–1187.
   PubMed Web of Science ®Google Scholar
• Stockley RA. 1984. Measurement of soluble proteins in lung secretions. Thorax. 39:241–247.
   PubMed Web of Science ®Google Scholar
• Stopford W, Turner J, Cappellini D, Brock T. 2003. Bioaccessibility testing of cobalt compounds. J Environ Monit. 5:675–680.
   PubMedGoogle Scholar
• Strupp C. 2011. Beryllium metal I. experimental results on acute oral toxicity, local skin and eye effects, and genotoxicity. Ann Occup Hyg. 55:30–42.
   PubMed Web of Science ®Google Scholar
• Suetake M, Nakano Y, Furuki G, Ikehara R, Komiya T, Kurihara E, Morooka K, Yamasaki S, Ohnuki T, Horie K, et al. 2019. Dissolution of radioactive, cesium-rich microparticles released from the Fukushima Daiichi Nuclear Power Plant in simulated lung fluid, pure-water, and seawater. Chemosphere. 233:633–644.
   PubMed Web of Science ®Google Scholar
• Sutinen S, Riska H, Backman R, Sutinen SH, Fröseth B. 1995. Alveolar lavage fluid (ALF) of normal volunteer subjects: cytologic, immunocytochemical, and biochemical reference values. Respir Med. 89:85–92.
   PubMed Web of Science ®Google Scholar
• Sysalova J, Szakova J, Tremlova J, Kasparovska K, Kotlik B, Tlustos P, Svoboda P. 2014. Methodological aspects of in vitro assessment of bio-accessible risk element pool in urban particulate matter. Biol Trace Elem Res. 161:216–222.
   PubMed Web of Science ®Google Scholar
• Tam A, Wadsworth S, Dorscheid D, Man SFP, Sin DD. 2011. The airway epithelium: more than just a structural barrier. Ther Adv Respir Dis. 5:255–273.
   PubMedGoogle Scholar
• Tan Z, Bai Q, Yin Y, Zhang Y, Chen Q, Moon MH, Liu J. 2020. On-line determination of soluble Zn content and size of the residual fraction in PM2.5 incubated in various aqueous media. Sci Total Environ. 724:138309.
   PubMed Web of Science ®Google Scholar
• Tappel AL. 1969. Lysosomal enzymes and other components. In: Dingle JT, Fell HB, editors. Lysosomal in biology and pathology. Amsterdam: Wiley. p. 1.
   Google Scholar
• Thelohan S, de Meringo A. 1994. In vitro dynamic solubility test: influence of various parameters. Environ Health Perspect. 102 :91–96.
   PubMed Web of Science ®Google Scholar
• Thompson AB, Bohling T, Payvandi F, Rennard SI. 1990. Lower respiratory tract lactoferrin and lysozyme arise primarily in the airways and are elevated in association with chronic bronchitis. J Lab Clin Med. 115:148–158.
   PubMed Web of Science ®Google Scholar
• Ungaro F, d'Emmanuele di Villa Bianca R, Giovino C, Miro A, Sorrentino R, Quaglia F, La Rotonda MI. 2009. Insulin-loaded PLGA/cyclodextrin large porous particles with improved aerosolization properties: in vivo deposition and hypoglycaemic activity after delivery to rat lungs. J Control Release. 135:25–34.
   PubMed Web of Science ®Google Scholar
• Utembe W, Potgieter K, Stefaniak AB, Gulumian M. 2015. Dissolution and biodurability: important parameters needed for risk assessment of nanomaterials. Part Fibre Toxicol. 12
   PubMed Web of Science ®Google Scholar
• van der Vliet A, O’Neill CA, Cross CE, Koostra JM, Volz WG, Halliwell B, Louie S. 1999. Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids. Am J Physiol. 276:L289–296.
   PubMed Web of Science ®Google Scholar
• Van Iwaarden JF, Pikaar JC, Storm J, Brouwer E, Verhoef J, Oosting RS, van Golde LMG, van Strijp JAG. 1994. Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides. Biochem J. 303:407–411.
   PubMed Web of Science ®Google Scholar
• Van Iwaarden JF, Shimizu H, Van Golde PHM, Voelker DR, Van Golde LMG. 1992. Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages. Biochem J. 286:5–8.
   PubMed Web of Science ®Google Scholar
• Vidrio E, Phuah CH, Dillner AM, Anastasio C. 2009. Generation of hydroxyl radicals from ambient fine particles in a surrogate lung fluid solution. Environ Sci Technol. 43:922–927.
   PubMed Web of Science ®Google Scholar
• Vigliaturo R, Della Ventura G, Choi J, Marengo A, Lucci F, O'Shea M, Pérez-Rodríguez I, Gieré R. 2018. Mineralogical characterization and dissolution experiments in Gamble’s solution of tremolitic amphibole from Passo di Caldenno (Sondrio, Italy). Minerals. 8:557.
   PubMed Web of Science ®Google Scholar
• Vitarella D, Moss O, Dorman DC. 2000. Pulmonary clearance of manganese phosphate, manganese sulfate, and manganese tetraoxide by CD rats following intratracheal instillation. Inhal Toxicol. 12:941–957.
   PubMed Web of Science ®Google Scholar
• Warheit DB, Hartsky MA, Reed KL, Webb TR. 2001. Biodegradability of inhaled para-aramid respirable-sized fiber-shaped particulates: mechanistic in vivo and in vitro studies. Toxicol Appl Pharmacol. 174:78–88.
   PubMed Web of Science ®Google Scholar
• Warheit DB, Hartsky MA, Webb TR. 2000. Biodegradability of inhaled p-aramid respirable fibre-shaped particulates: Representative of other synthetic organic fibre-types? Int Arch Occup Environ Health. 73:S75–S78.
   PubMed Web of Science ®Google Scholar
• Webber SE, Widdicombe JG. 1989. The transport of albumin across the ferret in vitro whole trachea. J Physiol. 408:457–472.
   PubMed Web of Science ®Google Scholar
• WHO. 1997. Determination of airborne fibre number concentrations; a recommended method by phase-contrast microscopy (membrane filter method).
   Google Scholar
• Widdicombe JH, Widdicombe JG. 1995. Regulation of human airway surface liquid. Respir Physiol. 99:3–12.
   PubMedGoogle Scholar
• Wiseman CLS, Niu J, Levesque C, Chenier M, Rasmussen PE. 2018. An assessment of the inhalation bioaccessibility of platinum group elements in road dust using a simulated lung fluid. Environ Pollut. 241:1009–1017.
   PubMed Web of Science ®Google Scholar
• Wiseman CLS, Zereini F. 2014. Characterizing metal(loid) solubility in airborne PM10, PM2.5 and PM1 in Frankfurt, Germany using simulated lung fluids. Atmos Environ. 89:282–289.
   Web of Science ®Google Scholar
• Witt EC, Shi HL, Wronkiewicz DJ, Pavlowsky RT. 2014. Phase partitioning and bioaccessibility of Pb in suspended dust from unsurfaced roads in Missouri-A potential tool for determining mitigation response. Atmos Environ. 88:90–98.
   Web of Science ®Google Scholar
• Wohlleben W, Waindok H, Daumann B, Werle K, Drum M, Egenolf H. 2017. Composition, respirable fraction and dissolution rate of 24 stone wool MMVF with their binder. Part Fibre Toxicol. 14:29.
   PubMed Web of Science ®Google Scholar
• Woods A, Andrian T, Sharp G, Bicer EM, Vandera KA, Patel A, Mudway I, Dailey LA, Forbes B. 2020. Development of new in vitro models of lung protease activity for investigating stability of inhaled biological therapies and drug delivery systems. Eur J Pharm Biopharm. 146:64–72.
   PubMed Web of Science ®Google Scholar
• Wragg J, Klinck B. 2007. The bioaccessibility of lead from Welsh mine waste using a respiratory uptake test. J Environ Sci Health A. 42:1223–1231.
   Web of Science ®Google Scholar
• Wragg J, Cave M, Basta N, Brandon E, Casteel S, Denys S, Gron C, Oomen A, Reimer K, Tack K, et al. 2011. An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil. Sci Total Environ. 409:4016–4030.
   PubMed Web of Science ®Google Scholar
• Wu J, Kobayashi M, Sousa EA, Liu W, Cai J, Goldman SJ, Dorner AJ, Projan SJ, Kavuru MS, Qiu Y, et al. 2005. Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge. Mol Cell Proteomics. 4:1251–1264.
   PubMed Web of Science ®Google Scholar
• Xie JJ, Yuan CG, Shen YW, Xie J, He KQ, Zhu HT, Zhang KG. 2019a. Bioavailability/speciation of arsenic in atmospheric PM2.5 and their seasonal variation: a case study in Baoding city, China. Ecotoxicol Environ Saf. 169:487–495.
   PubMed Web of Science ®Google Scholar
• Xie JJ, Yuan CG, Xie J, Shen YW, He KQ, Zhang KG. 2019b. Speciation and bioaccessibility of heavy metals in PM2.5 in Baoding city, China. Environ Pollut. 252:336–343.
   PubMed Web of Science ®Google Scholar
• Yoneda K. 1976. Mucous blanket of rat bronchus. Am Rev Respir Dis. 114:837–842.
   PubMedGoogle Scholar
• Zadpoor AA. 2014. Relationship between in vitro apatite-forming ability measured using simulated body fluid and in vivo bioactivity of biomaterials. Mater Sci Eng C Mater Biol Appl. 35:134–143.
   PubMed Web of Science ®Google Scholar
• Zadrapova D, Titera A, Szakova J, Cadkova Z, Cudlin O, Najmanova J, Tlustos P. 2019. Mobility and bioaccessibility of risk elements in the area affected by the long-term opencast coal mining. J Environ Sci Health A. 54:1159–1169.
   Web of Science ®Google Scholar
• Zereini F, Wiseman CL, Puttmann W. 2012. In vitro investigations of platinum, palladium, and rhodium mobility in urban airborne particulate matter (PM10, PM2.5, and PM1) using simulated lung fluids. Environ Sci Technol. 46:10326–10333.
   PubMed Web of Science ®Google Scholar
• Zhong L, Hu X, Cao Z, Wang H, Chen Y, Lian HZ. 2019. Aggregation and dissolution of engineering nano Ag and ZnO pretreated with natural organic matters in the simulated lung biological fluids. Chemosphere. 225:668–677.
   PubMed Web of Science ®Google Scholar
• Zhong MS, Jiang L. 2017. Refining health risk assessment by incorporating site-specific background concentration and bioaccessibility data of Nickel in soil. Sci Total Environ. 581-582:866–873.
   PubMed Web of Science ®Google Scholar
• Zhong LJ, Liu XL, Hu X, Chen YJ, Wang HW, Lian HZ. 2020. In vitro inhalation bioaccessibility procedures for lead in PM2.5 size fraction of soil assessed and optimized by in vivo-in vitro correlation. J Hazard Mater. 381:121202.
   PubMed Web of Science ®Google Scholar
• Zhong L, Yu Y, Lian HZ, Hu X, Fu H, Chen YJ. 2017. Solubility of nano-sized metal oxides evaluated by using in vitro simulated lung and gastrointestinal fluids: implication for health risks. J Nanopart Res. 19:375.
   Web of Science ®Google Scholar
• Zhou Y, Cheng YS, Wang Y. 2010. Dissolution rate and biokinetic model of zirconium tritide particles in rat lungs. Health Phys. 98:672–682.
   PubMed Web of Science ®Google Scholar
• Zoitos BK, DeMeringo A, Rouyer E, Thelohan S, Bauer J, Law B, Boymel PM, Olson JR, Christensen VR, Guldberg M, et al. 1997. In vitro measurement of fiber dissolution rate relevant to biopersistence at neutral pH: an interlaboratory round robin. Inhalation Toxicol. 9:525–540.
   Web of Science ®Google Scholar