Advanced search
Publication Cover
Leukemia & Lymphoma Volume 43, 2002 - Issue 9
Submit an article Journal homepage
233
Views
152
CrossRef citations to date
0
Altmetric
Research Article

Results of First Salvage Therapy for Patients Refractory to a Fludarabine Regimen in Chronic Lymphocytic Leukemia

M.J. Keating Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
,
S. O'Brien Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
,
D. Kontoyiannis Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
,
W. Plunkett Department of Cellular and Molecular Pharmacology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
,
C. Koller Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
,
M. Beran Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
,
S. Lerner Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
&
H. Kantarjian Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 61, Houston, TX 77030, USA
 show all
Pages 1755-1762 | Published online: 01 Jul 2009

  • Knospe, W.H., Loeb, Jr, V. and Huguley, Jr, C.M. (1974) "Biweekly chlorambucil treatment of chronic lymphocytic leukemia". Cancer 33. 555,.
  • Oken,M.M. and Kaplan, M.E.(1979) "Combination chemotherapy with cyclophosphamide. vincristine, and prednisone in the treatment of refractory chronic lymphocytic leukemia". Cancer Treatment Report 63, 441.
  • iepman, M. and Votaw, M.L. (1978) "The treatment of chronic lymphocytic leukemia with COP chemotherapy". Cancer 41,1664.
  • Kearing, M.J., Hester, J.P., McCrdie, K.B., Burgess, M.A., Murphy, W.K. and Freireich, E.J. (1990) "Long-term results of CAP therapy in chronic lymphoctyic teukemia", Leukemia and Lvmphoma 2, 391.
  • French Cooperative Group on Chronic Lymphocytic Leukemia(1986) "Effectiveness of "CHOP" regimen in advanced untreated chronic tymphocyfic leukemia", Lancet, 1346.
  • Keating, M.J., Scouros, M., Murphy, S., Kantarjian, H., Hester, J., McCredie, K.B., Hersh, E.M. and Freineich, E.J. (1988) "Multiple agent chemotherapy (POACH) in previously treated and untreated patients with chronic lymphocytic leukemia", Leukemia 2,157.
  • Grever, MR., Kopecky, K.J., Coltman, C.A., Files, J.C., Greenberg, B.R., Hutton, J.J., Talley, R., Von Hoff, D.D. and Balcerak, S.P. (1988) "Fludarabine inonophosphate: a potentially useful agent in chronic lymphocytic leukemia", Nouvelle Revue Francaise d'Hematologie 30,457.
  • Keating, M.J., Kantarjian, R. Talpaz, M., Redmen, J., Koller, C., Barlogie, B., Velasquez, W., Plunkett, W., Freireich, E.J. and McCredie, K.B. (1989) "Fludarabine: A new agent with major activity against chronic lymphocytic leukemia", Blood 74, 19.
  • Saven, A., Carrera, C.J., Carson, D.A., Beutler, E. and Pirn, L.D. (1991) "2-chlorodeoxyadenosine treatment of refractory chronic lymphocytic leukemia". Leukemia and Lymphoma 5, 133.
  • Greever, M.R., Leiby, J.M., Kraut, E.H., Welson, H.E., Neidhart, J.A., Wall, R.L. and Balcerzak, S.P. (1985) "Low-dose deoxycoformyein in lymphoid malignancy", Journal of Clinical Oncology 3, 1169.
  • Kearing, M.J., Kantarjian, H., O'Brien, S., Koller, C., Talpaz, M., Schachner, J., Childs, C.C., Freireich, E.J. and McCredie, K.B. (1991) "Fludarabine: A new agent with marked cytoreduclive activity In untreated chronic lymphocytic leukemia", Journal of Clinical Oncology 9,44.
  • The French Cooperative Group on CLL Johnson, S., Smith, A.C., Loffler, H., Osby, E., Juliusson, G., Eminerich, B., WyId, P.J. and Hiddemann, W. (1996) "Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubiein, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukemia", Lancet 347(9013), 1432-1438.
  • Rai, K.R., Peterson, B., Elias, L., Shepherd, L., Hines, J., Nelson, D., Cheson, B., Kolitz, and Schiffer, C.A. (1996) "A randomized comparison of Fludarabine and chlorarabucil for patients with previously untreated chronic lymphocytic leukemia. A CALGB, SWOG, CTG/NCI-C. and ECOG Inter-Group Study", Blood 88, 141a.
  • Khouri, I.F., Przepiorka, D., van Besten, K., O'Brien, S., Palmer, J.L., Lerner, S., Mehra, R.C., Vriesendorp, H.M., Andersson, B.S., Girait, S., Korbling, M., Kcating, M. and Champlin, R.E. (1997) "Allogeneic blood or marrow transplantation for chronic lymphocytic leukaemia: timing of transplantation and potential effect of fludarabine on acute graft-versus-host disease", British Journal of Haemaiology 97, 466-473.
  • Michallet, M., Archimbaud, E., Bandini, G., Rowlings, P.A., Degg, H.J., Gahrton, G., Montserrat, E, Rozman, C., Gratwohl, A. and Giale, R.P. (1996) "HLA-identical sibling bone marrow transplantation in younger patient with chronic lymphocytic leukemia", Annals of lnternal Medicine 124, 311-315.
  • Osterborg, A., Passas, A., Anagnostopoulos, A., et al., (1996) "Humanized CD52 monoclonal antibody CAMPATH-IH as firstline treatment in chronic lymphocytic leukemia", British Journal of Haematology 93,151-153.
  • Bowen, A.L., Zomas, A., Emett, E., et al., (1997) "Subcutaneous CAMPATH-IH in fludarabine-restsistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia", British Journal of Haematology 96,617-619.
  • O'Brien, S.M., Kantarjian, H., Thomas, O.A., Giles, F.J., Freireich, E.J., Cortes, J., Lemer, S. and Keating, M.J. (2002) "Rituximab dose-escalation trial in chronic lymphocytic leukemia", Journal of Clinical Oncology 19, 2165.
  • Byrd, J.C., Grever, M.R., Davis, B., Lucas, M.S., Part, K., Goodrich, K., Morrison, C., Murphy, T., Kunkel, L. Grillo-Lopez, A., Waselenko, J.K. and Flinn, l.W. (1999) "Phase I/II study of thrice weekly Riluximab in chronic lymphocytic leukemia (CLLJ/small lymphoctyic lymphoma (SLL): a feasible and active regimen", Blood 94, 3114.
  • Keating, M.J., O'Brien.S., Kantarjian, H.,et al.,(1993) "Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent", Blood 81, 2878-2884.
  • O'Brien, S., Kantarajian, H., Heran, M., Koller, C., Talpaz, M., Lemer, S., et al., (1997) "Fludarabine and granulocyte colonystimulating factor (G-CSF) in patients with chronic lymphocytic leukemia", Leukemia 11, 1631-1635.
  • Dyer, M.J.S., Kelsey, S.M., Mackay, H.J., et al., (1997) "In vivo "purging" of residual disease in CLL with Campath-IH", British Jaurnal of Haematology 97,669-672.
  • O'Brien, S., Kantarjian, H., Beran, M., et al, (1996) "Fladarabine and cyclophosphamide therapy in chronic lymphocytic leukemia", Blood 88,480a.
  • Gandhi, V., Kemena, A., Keating, M.J. and Plunkett, W. (1992) "Fludarabine infusion potentiates arabinusyleytosine metabolism in lymphocytes of patterns with chronic lymphocytic leukemia", Cancer Research 52, 897-903.
  • Robenson, L.E., O'Brien, S., Kantarjian, U., Koller, C., Beran, M., Andreef, M., Lerner, S. and Keating, M.J. (1995) "Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia", Leukemia 9, 943-945.
  • Giles, FJ., O'Brien, S.M., Santini, V., Gandhi, V., Plunkett, W., Seymour, J.F., Robenson, L.E. Kantarjian, H. and Keating, M.J. (1999) "Sequential cis-platinum and fludarabine with or without arabinosyl cytosine in patients failing prior fludarabine therapy for chronic lymphocytic leukemia: a phase II study", Leukemia and Lymphoma 36, 57-65.
  • O'Brien, S., Thomas, D., Kantarjian, H., Freireich, E., Koller, C., Cortes, J., Giles, F., Bivens, C., Lemer, U., Hodge, J., Spector, N. and Keating, M. (1998) "Compound 506 has activity in mature lymphoid leukemias", Blood 92,490a.
  • Juliusson, G., Elmborn-Rosenborg, A. and Liliemark, J. (1992) "Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphoeytic leukemia resistant to fludarabine", New England Journal of Medicine 327, 1056-1061.
  • O'Brien, S., Kantarjian, H., Estey, E., Koller, C. Robenson, B., Beran, M., Andreeff, M., Pierce, S. and Keating, M. (1994) "Lack of effect of 2-chlorodeoxyadenosine therapy in patients with chronic lymphocytic leukemia refractory to fludearabine therapy", New England Journal of Medicine 330,319-322.
  • Delannoy, A., Hanique, G. and Ferrant, A.(1993) "2-chlorode-oxyadenosine for pa with B-cell chronic Iymphocyltc leukemia resistant to fludarabine", New England Journal of Medicine 328, 812.
  • El Rouby, S., Burval, K., Juliusson, G., et al., (1993) "p53 mutation in B-cell chronic Iymphocytic leukemia is associated with drug resistanceand is independent of MDR1/MDR3 gene expression", Blood 82, 2702-2707.
  • Stilgenbauer, S., Dohner, K., Bentz, M., et al., "Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia", Annala of Hematology 76,101-110.
  • Holmes, J.A., Jacobs, A., Carter, G., Whittaker, J.A., Bentley, D.P. and Padua, R.A. (1990) "Is the indrl gene relevant in chronicIymphocytic leukemia?". Leukemia 4, 216.
  • Reed, J.C. (1997) "Bcl-2 family proteins in deregulation of apoptosis and chemoresistance in B-CLL", Hematology Cell Therapy 39,S22-S24.
  • Plunkett, W., Kawai, Y., Sandoval, A., O'Brien, S., Keating, M.J., Iluang, P. and Gandhi, V. (2002) "Mechanism-bascd rationales for combination therapies of lymphoid malignancies", lnternational Journal of Hematology, In press.
  • Keating, M.J., Smith, T.L., Lerner, S., O'Brien, S., Robertson, L.E., Katarjian, H. and Freinrlch, E.H. (1999) "Prediction of prognosis following fludarabine used as secondary therapy for chronic lymphocytic leukemia", Leukemia and Lvmphomar 36,1-15.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.