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Research Article

Specific Destruction of Hybridoma Cells by Antigen-toxin Conjugates Demonstrate an Efficient Strategy for Targeted Drug Therapy in Leukemias of the B Cell Lineage

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Pages 681-689 | Published online: 01 Jul 2009

  • Nishida, K., Tamura, A., Nakazawa, N., Ueda, Y., Abe, T., Matsuda, F., et al. (1997) "The Ig heavy chain is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization", Blood 90, 526-534.
  • Drexler, H.G. and Matsuo, Y. (2000) "Malignant hematopoietic cell lines: in vitro models for the study of multiplemyeloma and plasma cell leukemia", Leukemia Research 24, 681-703.
  • Lockhurst, H. M., Sonneveld, P. and Verdonck, L.F. (1991) "Intensive treatment for multiple myeloma: where do we stand", Blood 106, 18-27.
  • Raje, N. and Anderson, K.C. (2000) "Introduction: the evolving role of bisphosphanate therapy in multiple myeloma", Blood 96, 381-383.
  • Smith, M.L. and Newland, A.C. (1999) "Treatment of myeloma", Quarterly Journal of Medicine 92, 4-11.
  • Morgan, G.J. (1999) "Advances in the biology and treatment of myeloma", British Journal of Hematology 105(Suppl. 1), 4-67.
  • Gadó, K., Domján, G., Hegyesi, H. and Falus, A. (2000) "Role of interleukin-6 in the pathogenesis of multiple myeloma", Cell Biology International 24, 195-209.
  • Kreitman, R. (2000) "Immunotoxins", Expert Opinion in Pharmacotherapy 1, 1117-1129.
  • Treon, S.P., Shima, Y., Grossbard, M.L., Preffer, F.I., Belch, A.R., Pilarski, L.M., et al. (2000) "Treatment of plasma cell dyscrasias by antibody-mediated immunotherapy and induction of myeloma selective antigens", Annals of Oncology 11(Suppl. 1), 107-111.
  • Ohtomo, T., Sugamota, V., Ozoki, Y., Ono, K., Yoshimuro, Y., Kawai, S., et al. (1999) "Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells", Biochemical and Biophysical Research Commununications 258, 583-591.
  • Vitetta, E.S., Thorpe, P.E. and Uhr, J.W. (1993) "Magic bullets or misguided missiles?", Immunology Today 14, 252-259.
  • Press, O.W., Martin, J.P., Thorpe, P.E and Vitetta, E.S. (1998) "Ricin-A chain containing immunotoxins directed against different epitopes on the CD2 molecule differ in their ability to kill normal and malignant T cells", Journal of Immunology 141, 4410-4417.
  • Rihova, B. (1998) "Receptor-mediated targeted or toxin delivery", Advanced Drug Delivery Reviews 29, 273-289.
  • Kosmos, C., Stamatopolous, K., Belessi, C., Yataganas, X., Anagnostou, D. and Loukopoulos, A. (1998) "Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma", Immunology Reviews 162, 281-292.
  • Bakkhus, M.H., Heirman, C., Van Riet, I., Van Camp, B. and Thielemans, K. (1992) "Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variations", Blood 80, 2326-2335.
  • Vescio, R.A., Cao, J., Hong, C.H., Lee, J.C., Wu, C.H., Der Danielian, M., et al. (1995) "Myeloma Ig heavy chain V region sequences reveal prior antigen selection and marked somatic mutation but no intraclonal variation", Journal of Immunology 155, 2487-2497.
  • Berenson, J.R., Vescio, R.A. and Said, I. (1998) "Multiple myeloma: the cells of origin--a two way street", Leukemia 12, 121-127.
  • Czerwinski, G., Tarasove, N. and Michejda, C.J. (1998) "Cytotoxic agents directed to peptide hormone receptors: defining the requirements for a successful drug", Proceeding of the National Academy of Science, USA 95, 11520-11525.
  • Harris, A.L. (1990) "The epidermal growth factor receptor as a target for therapy", Cancer Cells 2, 321-323.
  • Pastan, I. and Fitzgerald, D. (1991) "Recombinant toxins for cancer treatment", Science 254, 1173-1177.
  • Davol, P.A., Bizuneh, A. and Frackelton, Jr., A.R. (1999) "Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo", Anticancer Research 19, 1705-1714.
  • McIntyre, G.D., Scott, C.F., Ritz, J., Bluttler, W.A. and Lambert, J.M. (1994) "Preparation and characterization of interleukin-2-gclonin conjugates made using different cross-linking reagents", Bioconjugate Chemistry 5, 88-97.
  • Volkman, D.J., Ahmad, A., Fauci, A.S. and Neville, D.M. (1982) "Selective abrogation of antigen specific human B cell responses by antigen-ricin conjugates", Journal of Experimental Medicine 156, 634-639.
  • Green, B.S., DeSouza, L.J., Arad-Yellin, R., Firer, M.A., Knossow, M. and Gigant, B. (1998) "Antibody-catalyzed reactions using novel haptens or designed substrates", The Immunologist 6(Suppl. 1), 119.
  • Gan, Y.H., Peng, S.Q. and Liu, H.Y. (2000) "Molecular mechanisms of apoptosis induced by ricin in HeLa cells", Acta Pharmacology (Singapore) 21, 243-248.
  • Hu, R., Zhai, Q., Liu, W. and Liu, X. (2001) "An insight into the mechanism of cytotoxicity of ricin to hepatoma cell: roles of Bcl-2 family proteins, caspases, Ca(2 + )-dependent proteases and protein kinase C", Journal of Cellular Biochemistry 81, 583-593.
  • Komatsu, N., Nakagawa, M., Oda, T. and Muramatsu, T. (2000) "Depletion of intracellular NAD + and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells", Journal of Biochemistry 128, 463-470.
  • Sandvig, K. and van Duers, B. (2000) "Entry of ricin and shiga toxin into cells: molecular mechanisms and medical perspectives", EMBO Journal 19, 5943-5950.
  • Geiseler, F. and Nubler, V. (1997) "Cellular resistance mechanisms with impact on the therapy of multiple myeloma", Leukemia 11(Suppl. 5), S1-S4.
  • Campone, M., Vavasseur, F., Le Cabellec, M.T., Meflah, K., Vallente, F.M. and Oliver, L. (2001) "Induction of chemoresistance in HL-60 cells concomitantly causes a resistance to apoptosis and the synthesis of P-glycoprotein", Leukemia 15, 1377-1387.
  • Aisenberg, A.C. and Bloch, K.J. (1972) "Immunoglobulins on the surface of neoplastic lymphocytes", New England Journal of Medicine 287, 272-276.
  • Sato, I., Abo, T., Onodera, S. and Kumagai, K. (1978) "Detection of monoclonal B lymphocytes in multiple myeloma by immunofluorescence tests of surface immunoglobulins", Scandinavian Journal of Haematology 21, 433-444.
  • Ocqueteau, M., San Miguel, J.F., Gonzalez, M., Almeida, J. and Orfao, A. (1996) "Do myelomatous plasma cells really express surface immunoglobulins?", Haematologica 81, 460-463.
  • Thurnheer, C.M., Zuercher, A.W., Miescher, S.M., Rudolf, M.P., Vogel, M. and Stadler, B.M. (1999) "Molecular mimicry of the unidentified antigen of antibody IgE-ND", European Journal of Immunology 29, 2676-2683.

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