Hematopoiesis and Retinoids: Development and Disease

References

• Collins, S.J. (2002) �The role of retinoids and retinoic acid receptors in normal hematopoiesis", Leukemia 16, 1896–1905.
   Google Scholar
• Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Kuchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W. and Brand, M. (2002) "Retinoic acid signalling in the zebrafish embryo is necessary during presegmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud", Development 129, 2851–2865.
   PubMed Web of Science ®Google Scholar
• Thompson Haskell, G., Maynard, T.M., Shatzmiller, R.A. and Lamantia, A.S. (2002) "Retinoic acid signaling at sites of plasticity in the mature central nervous system", Journal of Comparative Neurology 452, 228–241.
   PubMed Web of Science ®Google Scholar
• Kostetskii, I., Jiang, Y., Kostetskaia, E., Yuan, S., Evans, T. and Zile, M. (1999) "Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation", Developmental Biology 206, 206–218.
   PubMed Web of Science ®Google Scholar
• Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P. and Dolle, P. (2001) "Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse", Development 128, 1019–1031.
   PubMed Web of Science ®Google Scholar
• Zile, M.H. (2001) "Function of vitamin A in vertebrate embryonic development", Journal of Nutrition 131, 705–708.
   PubMed Web of Science ®Google Scholar
• Uni, Z., Zaiger, G., Gal-Garber, O., Pines, M., Rozenboim, I. and Reifen, R. (2000) "Vitamin A deficiency interferes with proliferation and maturation of cells in the chicken small intestine", British Poultry Science 41, 410–415.
   PubMed Web of Science ®Google Scholar
• Sporn, M.B., Roberts, A.B. and Goodman, D.S. (1994) The Retinoids: Biology, Chemistry, and Medicine, 2nd Ed. (Raven Press, New York).
   Google Scholar
• Wolf, G. (1984) "Multiple functions of vitamin A", Physiological Reviews 64, 873–937.
   PubMed Web of Science ®Google Scholar
• Ross, S.A., McCaffery, P.J., Drager, U.C. and De Luca, L.M. (2000) "Retinoids in embryonal development", Physiological Reviews 80, 1021–1054.
   PubMed Web of Science ®Google Scholar
• Mangelsdorf, D.J. and Evans, R.M. (1995) "The RXR heterodimers and orphan receptors", Cell 83, 841–850.
   PubMed Web of Science ®Google Scholar
• Levin, A.A., Sturzenbecker, L.J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberger, M., Lovey, A., et al. (1992) "9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha", Nature 355, 359–361.
   PubMed Web of Science ®Google Scholar
• Gratas, C., Menot, M.L., Dresch, C. and Chomienne, C. (1993) "Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells", Leukemia 7, 1156–1162.
   PubMed Web of Science ®Google Scholar
• Labbaye, C., Valtieri, M., Testa, U., Giampaolo, A., Meccia, E., Sterpetti, P., Parolini, I., Pelosi, E., Bulgarini, D., Cayre, Y.E., et al. (1994) "Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture", Blood 83, 651–656.
   PubMed Web of Science ®Google Scholar
• Van Bockstaele, D.R., Lenjou, M., Snoeck, H.W., Lardon, F. and Peetermans, M.E. (1994) "Effect of retinoic acid (RA) on myeloid progenitors in normal bone marrow (BM)", Leukemia 8, 214–215.
   PubMed Web of Science ®Google Scholar
• Tocci, A., Parolini, I., Gabbianelli, M., Testa, U., Luchetti, L., Samoggia, P., Masella, B., Russo, G., Valtieri, M. and Peschle, C. (1996) "Dual action of retinoic acid on human embryonic/fetal hematopoiesis: blockade of primitive progenitor proliferation and shift from multipotent/erythroid/monocytic to granulocytic differentiation program", Blood 88, 2878–2888.
   PubMed Web of Science ®Google Scholar
• Tsai, S., Bartelmez, S., Sitnicka, E. and Collins, S. (1994) "Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development", Genes and Development 8, 2831–2841.
   PubMed Web of Science ®Google Scholar
• Purton, L.E., Bernstein, I.D. and Collins, S.J. (1999) "All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-kit � Sca-1(�)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors", Blood 94, 483–495.
   PubMed Web of Science ®Google Scholar
• Purton, L.E., Bernstein, I.D. and Collins, S.J. (2000) "All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells", Blood 95, 470–477.
   PubMed Web of Science ®Google Scholar
• Zauli, G., Visani, G., Vitale, M., Gibellini, D., Bertolaso, L. and Capitani, S. (1995) "All-trans retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD34� haemopoietic progenitor cells", British Journal of Haematology 90, 274–282.
   PubMed Web of Science ®Google Scholar
• Douer, D. and Koeffler, H.P. (1982) "Retinoic acid enhances growth of human early erythroid progenitor cells in vitro", Journal of Clinical Investigation 69, 1039–1041.
   PubMed Web of Science ®Google Scholar
• Kastner, P., Lawrence, H.J., Waltzinger, C., Ghyselinck, N.B., Chambon, P. and Chan, S. (2001) "Positive and negative regulation of granulopoiesis by endogenous RARalpha", Blood 97, 1314–1320.
   PubMed Web of Science ®Google Scholar
• Zhu, J., Heyworth, C.M., Glasow, A., Huang, Q.H., Petrie, K., Lanotte, M., Benoit, G., Gallagher, R., Waxman, S., Enver, T. and Zelent, A. (2001) "Lineage restriction of the RARalpha gene expression in myeloid differentiation", Blood 98, 2563–2567.
   PubMed Web of Science ®Google Scholar
• Si, J. and Collins, S.J. (2002) "IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3- dependent manner", Blood 100, 4401–4409.
   PubMed Web of Science ®Google Scholar
• Mark, M., Ghyselinck, N.B., Wendling, O., Dupe, V., Mascrez, B., Kastner, P. and Chambon, P. (1999) "A genetic dissection of the retinoid signalling pathway in the mouse", Proceedings of the Nutrition Society 58, 609–613.
   PubMed Web of Science ®Google Scholar
• Labrecque, J., Allan, D., Chambon, P., Iscove, N.N., Lohnes, D. and Hoang, T. (1998) "Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors alpha1 and gamma", Blood 92, 607–615.
   PubMed Web of Science ®Google Scholar
• Makita, T., Hernandez-Hoyos, G., Chen, T.H., Wu, H., Rothenberg, E.V. and Sucov, H.M. (2001) "A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4", Genes and Development 15, 889–901.
   PubMed Web of Science ®Google Scholar
• Kambe, T., Tada-Kambe, J., Kuge, Y., Yamaguchi-Iwai, Y., Nagao, M. and Sasaki, R. (2000) "Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer", Blood 96, 3265–3271.
   PubMed Web of Science ®Google Scholar
• Dolle, P., Ruberte, E., Leroy, P., Morriss-Kay, G. and Chambon, P. (1990) "Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis", Development 110, 1133–1151.
   PubMed Web of Science ®Google Scholar
• Niederreither, K., Subbarayan, V., Dolle, P. and Chambon, P. (1999) "Embryonic retinoic acid synthesis is essential for early mouse post-implantation development", Nature Genetics 21, 444–448.
   PubMed Web of Science ®Google Scholar
• Heine, U.I., Roberts, A.B., Munoz, E.F., Roche, N.S. and Sporn, M.B. (1985) "Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo", Virchows Archiv. B, Cell Pathology Including Molecular Pathology 50, 135–152.
   Google Scholar
• Ghatpande, S., Ghatpande, A., Sher, J., Zile, M.H. and Evans, T. (2002) "Retinoid signaling regulates primitive (yolk sac) hematopoiesis", Blood 99, 2379–2386.
   PubMed Web of Science ®Google Scholar
• Mejia, L.A., Hodges, R.E. and Rucker, R.B. (1979) "Clinical signs of anemia in vitamin A-deficient rats", American Journal of Clinical Nutrition 32, 1439–1444.
   PubMed Web of Science ®Google Scholar
• Hayes, K.C. (1971) "On the pathophysiology of vitamin A deficiency", Nutrition Reviews 29, 3–6.
   PubMedGoogle Scholar
• Dersch, H. and Zile, M.H. (1993) "Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids", Developmental Biology 160, 424–433.
   PubMed Web of Science ®Google Scholar
• Zhang, C. and Evans, T. (1996) "BMP-like signals are required after the midblastula transition for blood cell development", Developmental Genetics 18, 267–278.
   PubMedGoogle Scholar
• Rodriguez-Leon, J., Merino, R., Macias, D., Ganan, Y., Santesteban, E. and Hurle, J.M. (1999) "Retinoic acid regulates programmed cell death through BMP signalling", Nature Cell Biology 1, 125–126.
   PubMed Web of Science ®Google Scholar
• Palis, J., Chan, R.J., Koniski, A., Patel, R., Starr, M. and Yoder, M.C. (2001) "Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis", Proceedings of the National Academy of Sciences of the United States of America 98, 4528–4533.
   PubMed Web of Science ®Google Scholar
• van Bennekum, A.M., Wong Yen Kong, L.R., Gijbels, M.J., Tielen, F.J., Roholl, P.J., Brouwer, A. and Hendriks, H.F. (1991) "Mitogen response of B cells, but not T cells, is impaired in adult vitamin A-deficient rats", Journal of Nutrition 121, 1960–1968.
   PubMed Web of Science ®Google Scholar
• Wiedermann, U., Hanson, L.A., Kahu, H. and Dahlgren, U.I. (1993) "Aberrant T-cell function in vitro and impaired T-cell dependent antibody response in vivo in vitamin A-deficient rats", Immunology 80, 581–586.
   PubMed Web of Science ®Google Scholar
• Kuwata, T.,Wang, I.M., Tamura, T., Ponnamperuma, R.M., Levine, R., Holmes, K.L., Morse, H.C., De Luca, L.M. and Ozato, K. (2000) "Vitamin A deficiency in mice causes a systemic expansion of myeloid cells", Blood 95, 3349–3356.
   PubMed Web of Science ®Google Scholar
• Degos, L. and Wang, Z.Y. (2001) "All trans retinoic acid in acute promyelocytic leukemia", Oncogene 20, 7140–7145.
   PubMed Web of Science ®Google Scholar
• Breitman, T.R., Collins, S.J. and Keene, B.R. (1981) "Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid", Blood 57, 1000–1004.
   PubMed Web of Science ®Google Scholar
• Huang, M.E., Ye, Y.C., Chen, S.R., Chai, J.R., Lu, J.X., Zhoa, L., Gu, L.J. andWang, Z.Y. (1988) "Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia", Blood 72, 567–572.
   PubMed Web of Science ®Google Scholar
• Borrow, J., Goddard, A.D., Sheer, D. and Solomon, E. (1990) "Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17", Science 249, 1577–1580.
   PubMed Web of Science ®Google Scholar
• de The, H., Chomienne, C., Lanotte, M., Degos, L. and Dejean, A. (1990) "The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus", Nature 347, 558–561.
   PubMed Web of Science ®Google Scholar
• Longo, L., Pandolfi, P.P., Biondi, A., Rambaldi, A., Mencarelli, A., Lo Coco, F., Diverio, D., Pegoraro, L., Avanzi, G., Tabilio, A., et al. (1990) "Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias", Journal of Experimental Medicine 172, 1571–1575.
   PubMed Web of Science ®Google Scholar
• Miller, W.H., Jr, Warrell, R.P., Jr, Frankel, S.R., Jakubowski, A., Gabrilove, J.L., Muindi, J. and Dmitrovsky, E. (1990) "Novel retinoic acid receptor-alpha transcripts in acute promyelocytic leukemia responsive to all-trans-retinoic acid", Journal of the National Cancer Institute 82, 1932–1933.
   Web of Science ®Google Scholar
• Zelent, A., Guidez, F., Melnick, A., Waxman, S. and Licht, J.D. (2001) "Translocations of the RARalpha gene in acute promyelocytic leukemia", Oncogene 20, 7186–7203.
   PubMed Web of Science ®Google Scholar
• Kastner, P., Perez, A., Lutz, Y., Rochette-Egly, C., Gaub, M.P., Durand, B., Lanotte, M., Berger, R. and Chambon, P. (1992) "Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins", EMBO Journal 11, 629–642.
   PubMed Web of Science ®Google Scholar
• Chen, Z., Guidez, F., Rousselot, P., Agadir, A., Chen, S.J., Wang, Z.Y., Degos, L., Zelent, A., Waxman, S. and Chomienne, C. (1994) "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors", Proceedings of the National Academy of Sciences of the United States of America 91, 1178–1182.
   PubMed Web of Science ®Google Scholar
• Grignani, F., Ferrucci, P.F., Testa, U., Talamo, G., Fagioli, M., Alcalay, M., Mencarelli, A., Peschle, C., Nicoletti, I., et al. (1993) "The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells", Cell 74, 423–431.
   PubMed Web of Science ®Google Scholar
• Alland, L., Muhle, R., Hou, H., Jr, Potes, J., Chin, L., Schreiber- Agus, N. and DePinho, R.A. (1997) "Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression", Nature 387, 49–55.
   PubMed Web of Science ®Google Scholar
• Heinzel, T., Lavinsky, R.M., Mullen, T.M., Soderstrom, M., Laherty, C.D., Torchia, J., Yang,W.M., Brard, G., Ngo, S.D., Davie, J.R., Seto, E., Eisenman, R.N., Rose, D.W., Glass, C.K. and Rosenfeld, M.G. (1997) "A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression", Nature 387, 43–48.
   PubMed Web of Science ®Google Scholar
• Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L. and Evans, R.M. (1997) "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase", Cell 89, 373–380.
   PubMed Web of Science ®Google Scholar
• Guidez, F., Ivins, S., Zhu, J., Soderstrom, M., Waxman, S. and Zelent, A. (1998) "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia", Blood 91, 2634–2642.
   PubMed Web of Science ®Google Scholar
• Hong, S.H., David, G.,Wong, C.W., Dejean, A. and Privalsky, M.L. (1997) "SMRT corepressor interacts with PLZF and with the PMLretinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia", Proceedings of the National Academy of Sciences of the United States of America 94, 9028–9033.
   Google Scholar
• Lin, R.J., Nagy, L., Inoue, S., Shao, W., Miller, Jr, W.H. and Evans, R.M. (1998) "Role of the histone deacetylase complex in acute promyelocytic leukaemia", Nature 391, 811–814.
   Google Scholar
• Grignani, F., De Matteis, S., Nervi, C., Tomassoni, L., Gelmetti, V., Cioce, M., Fanelli, M., Ruthardt, M., Ferrara, F.F., Zamir, I., Seiser, C., Lazar, M.A., Minucci, S. and Pelicci, P.G. (1998) "Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia", Nature 391, 815–818.
   PubMed Web of Science ®Google Scholar
• Hong, S.H. and Privalsky, M.L. (2000) "The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export", Molecular and Cellular Biology 20, 6612–6625.
   PubMed Web of Science ®Google Scholar
• Lin, R.J. and Evans, R.M. (2000) "Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers", Molecular Cell 5, 821–830.
   PubMed Web of Science ®Google Scholar
• Licht, J.D., Chomienne, C., Goy, A., Chen, A., Scott, A.A., Head, D.R., Michaux, J.L., Wu, Y., DeBlasio, A., Miller, W.H., Jr, et al. (1995) "Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)", Blood 85, 1083–1094.
   PubMed Web of Science ®Google Scholar
• Momparler, R.L., Eliopoulos, N. and Ayoub, J. (2000) "Evaluation of an inhibitor of DNA methylation, 5-aza-20- deoxycytidine, for the treatment of lung cancer and the future role of gene therapy", Advances in Experimental Medicine and Biology 465, 433–446.
   PubMed Web of Science ®Google Scholar
• Di Croce, L., Raker, V.A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Lo Coco, F., Kouzarides, T., Nervi, C., Minucci, S. and Pelicci, P.G. (2002) "Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor", Science 295, 1079–1082.
   PubMed Web of Science ®Google Scholar
• Brown, D., Kogan, S., Lagasse, E., Weissman, I., Alcalay, M., Pelicci, P.G., Atwater, S. and Bishop, J.M. (1997) "A PMLRARalpha transgene initiates murine acute promyelocytic leukemia", Proceedings of the National Academy of Sciences of the United States of America 94, 2551–2556.
   PubMed Web of Science ®Google Scholar
• Grisolano, J.L., Wesselschmidt, R.L., Pelicci, P.G. and Ley, T.J. (1997) "Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences", Blood 89, 376–387.
   PubMed Web of Science ®Google Scholar
• He, L.Z., Tribioli, C., Rivi, R., Peruzzi, D., Pelicci, P.G., Soares, V., Cattoretti, G. and Pandolfi, P.P. (1997) "Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice", Proceedings of the National Academy of Sciences of the United States of America 94, 5302–5307.
   PubMed Web of Science ®Google Scholar
• Cheng, G.X., Zhu, X.H., Men, X.Q., Wang, L., Huang, Q.H., Jin, X.L., Xiong, S.M., Zhu, J., Guo, W.M., Chen, J.Q., Xu, S.F., So, E., Chan, L.C.,Waxman, S., Zelent, A., Chen, G.Q., Dong, S., Liu, J.X. and Chen, S.J. (1999) "Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPMRARalpha", Proceedings of the National Academy of Sciences of the United States of America 96, 6318–6323.
   PubMed Web of Science ®Google Scholar
• He, L.Z., Guidez, F., Tribioli, C., Peruzzi, D., Ruthardt, M., Zelent, A. and Pandolfi, P.P. (1998) "Distinct interactions of PMLRARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL", Nature Genetics 18, 126–135.
   PubMed Web of Science ®Google Scholar
• Rego, E.M. and Pandolfi, P.P. (2002) "Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders?", Trends in Molecular Medicine 8, 396–405.
   PubMed Web of Science ®Google Scholar
• Pollock, J.L., Westervelt, P., Kurichety, A.K., Pelicci, P.G., Grisolano, J.L. and Ley, T.J. (1999) "A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalphadriven acute promyelocytic leukemia", Proceedings of the National Academy of Sciences of the United States of America 96, 15103–15108.
   PubMed Web of Science ®Google Scholar
• He, L.Z., Bhaumik, M., Tribioli, C., Rego, E.M., Ivins, S., Zelent, A. and Pandolfi, P.P. (2000) "Two critical hits for promyelocytic leukemia", Molecular Cell 6, 1131–1141.
   PubMed Web of Science ®Google Scholar
• Wang, Z.G., Ruggero, D., Ronchetti, S., Zhong, S., Gaboli, M., Rivi, R. and Pandolfi, P.P. (1998) "PML is essential for multiple apoptotic pathways", Nature Genetics 20, 266–272.
   PubMed Web of Science ®Google Scholar
• Rego, E.M., Wang, Z.G., Peruzzi, D., He, L.Z., Cordon-Cardo, C. and Pandolfi, P.P. (2001) "Role of promyelocytic leukemia (PML) protein in tumor suppression", Journal of Experimental Medicine 193, 521–529.
   PubMed Web of Science ®Google Scholar
• Barna, M., Hawe, N., Niswander, L. and Pandolfi, P.P. (2000) "Plzf regulates limb and axial skeletal patterning", Nature Genetics 25, 166–172.
   PubMed Web of Science ®Google Scholar
• Merghoub, T., Gurrieri, C., Piazza, F. and Pandolfi, P.P. (2001) "Modeling acute promyelocytic leukemia in the mouse: new insights in the pathogenesis of human leukemias", Blood Cells, Molecules, and Diseases 27, 231–248.
   Google Scholar
• Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H., Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H. and Linch, D.C. (2001) "The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials", Blood 98, 1752–1759.
   PubMed Web of Science ®Google Scholar
• Kelly, L.M., Kutok, J.L., Williams, I.R., Boulton, C.L., Amaral, S.M., Curley, D.P., Ley, T.J. and Gilliland, D.G. (2002) "PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model", Proceedings of the National Academy of Sciences of the United States of America 99, 8283–8288.
   PubMed Web of Science ®Google Scholar
• Le Beau, M.M., Bitts, S., Davis, E.M. and Kogan, S.C. (2002) "Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia", Blood 99, 2985–2991.
   PubMed Web of Science ®Google Scholar
• Warrell, R.P., Jr, Frankel, S.R., Miller, W.H., Jr, Scheinberg, D.A., Itri, L.M., Hittelman, W.N., Vyas, R., Andreeff, M., Tafuri, A., Jakubowski, A., et al. (1991) "Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid)", New England Journal of Medicine 324, 1385–1393.
   PubMed Web of Science ®Google Scholar
• He, L.Z., Tolentino, T., Grayson, P., Zhong, S., Warrell, R.P., Jr, Rifkind, R.A., Marks, P.A., Richon, V.M. and Pandolfi, P.P. (2001) "Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia", Journal of Clinical Investigation 108, 1321–1330.
   PubMed Web of Science ®Google Scholar
• Licht, J.D. (2001) "Targeting aberrant transcriptional repression in leukemia: a therapeutic reality?", Journal of Clinical Investigation 108, 1277–1278.
   PubMed Web of Science ®Google Scholar
• Altucci, L., Rossin, A., Raffelsberger,W., Reitmair, A., Chomienne, C. and Gronemeyer, H. (2001) "Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL", Nature Medicine 7, 680–686.
   PubMed Web of Science ®Google Scholar
• Bunn, H.F., Gu, J., Huang, L.E., Park, J.W. and Zhu, H. (1998) "Erythropoietin: a model system for studying oxygen-dependent gene regulation", Journal of Experimental Biology 201\(Pt 8), 1197–1201.
   PubMed Web of Science ®Google Scholar