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Original Articles: Research

Down-regulation of Notch-1 increases co-cultured Jurkat cell sensitivity to chemotherapy

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Pages 270-278 | Received 21 Aug 2008, Accepted 14 Oct 2008, Published online: 01 Jul 2009

References

  • Liang R, Huang G S, Wang Z, Chen X Q, Bai Q X, Zhang Y Q, et al. Effects of human bone marrow stromal cell line (HFCL) on the proliferation, differentiation and apoptosis of acute myeloid leukemia cell lines U937, HL-60 and HL-60/VCR. Int J Hematol 2008; 87: 152–166
  • Nefedova Y, Cheng P, Alsina M, Dalton W S, Gabrilovich D I. Involvement of Notch-1 signaling in bone marrow stroma – mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood 2004; 103: 3503–3510
  • Rothenberg E V. Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals. Immunity 2007; 26: 690–702
  • Fischer A, Gessler M. Delta-notch – and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 2007; 35: 4583–4596
  • Ellisen L W, Bird J, West D C, Soreng A L, Reynolds T C, Smith S D, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66: 649–661
  • Weng A P, Nam Y, Wolfe M S, Pear W S, Griffin J D, Blacklow S C, et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003; 23: 655–664
  • Weng A P, Ferrando A A, Lee W, Morris J P, IV, Silverman L B, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269–271
  • Jang J, Choi Y I, Choi J, Lee K Y, Chung H, Jeon S H, et al. Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter. Cell Death Differ 2006; 13: 1495–1505
  • Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem 2004; 279: 2937–2944
  • Mungamuri S K, Yang X, Thor A D, Somasundaram K. Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res 2006; 66: 4715–4724
  • Nefedova Y, Sullivan D M, Bolick S C, Dalton W S, Gabrilovich D I. Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood 2008; 111: 2220–2229
  • Kogoshi H, Sato T, Koyama T, Nara N, Tohda S. γ-secretase inhibitors suppress the growth of leukemia and lymphoma cells. Oncol Rep 2007; 18: 77–80
  • Katoh M, Katoh M. Notch signaling in gastrointestinal tract. Int J Oncol 2007; 3: 247–251
  • Pissarnitski D. Advances in γ-secretase modulation. Curr Opin Drug Discov Devel 2007; 10: 392–402
  • Lagneaux L, Delforge A, Bron D, De Bruyn C, Stryckmans P. Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 1998; 91: 2387–2396
  • Dankbar B, Padró T, Leo R, Feldmann B, Kropff M, Mesters R M, et al. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood 2000; 95: 2630–2636
  • Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, et al. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res 2007; 67: 684–694
  • Winter S S, Sweatman J, Shuster J J, Link M P, Amylon M D, Pullen J, et al. Bone marrow stroma-supported culture of T-lineage acute lymphoblastic leukemic cells predicts treatment outcome in children: a pediatric oncology group study. Leukemia 2002; 16: 1121–1126
  • Scupoli M T, Perbellini O, Krampera M, Vinante F, Cioffi F, Pizzolo G. Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma. Haematologica 2007; 92: 264–266
  • Rutz S, Mordmüller B, Sakano S, Scheffold A. Notch ligands δ-like1, δ-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol 2005; 35: 2443–2451
  • Bash J, Zong W X, Banga S, Rivera A, Ballard D W, Ron Y, et al. Rel/NF-κB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J 1999; 18: 2803–2811
  • Palomero T, Sulis M L, Cortina M, Real P J, Barnes K, Ciofani M, et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007; 13: 1203–1210
  • Rangarajan A, Syal R, Selvarajah S, Chakrabarti O, Sarin A, Krishna S. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology 2001; 286: 23–30
  • Nair P, Somasundaram K, Krishna S. Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J Virol 2003; 77: 7106–7112
  • Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J Immunol 2006; 177: 5041–5050
  • Foltz D R, Santiago M C, Berechid B E, Nye J S. Glycogen synthase kinase-3β modulates notch signaling and stability. Curr Biol 2002; 12: 1006–1011

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