135
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Graft failure after “ex-vivo” T-cell depleted haploidentical transplantation in pediatric patients with high-risk hematological malignancies. A risk factors and outcomes analysis

ORCID Icon, , , , , , , , , & show all
Pages 3130-3137 | Received 06 Mar 2021, Accepted 03 Jul 2021, Published online: 15 Jul 2021

References

  • Rocha V, Locatelli F. Searching for alternative hematopoietic stem cell donors for pediatric patients. Bone Marrow Transplant. 2008;41(2):207–214.
  • Martelli MF, Reisner Y. Haploidentical “'megadose' CD34+ cell transplants for patients with acute leukemia”. Leukemia. 2002;16(3):404–405.
  • Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med. 1998;339(17):1186–1193.
  • Reisner Y, Aversa F, Martelli MF. Haploidentical hematopoietic stem cell transplantation: state of art. Bone Marrow Transplant. 2015;50(S2):S1–S53.
  • Martelli MF, Aversa F. Haploidentical transplants using ex vivo T-cell depletion. Semin Hematol. 2016;53(4):252–256.
  • Anasetti C, Amos D, Beatty PG, et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med. 1989;320(4):197–204.
  • Kernan NA, Flomenberg N, Dupont B, et al. Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia. Identification of host-derived antidonor allocytotoxic T lymphocytes. Transplantation. 1987;43(6):842–847.
  • Yoshihara S, Maruya E, Taniguchi K, et al. Risk and prevention of graft failure in patients with preexisting donor-specific HLA antibodies undergoing unmanipulated haploidentical SCT. Bone Marrow Transplant. 2012;47(4):508–515.
  • Bramanti S, Calafiore V, Longhi E, et al. Donor-specific anti-HLA antbodies in haploidentical stem cell transplantation with post-cyclophosphamide: risk of graft failure, poor graft function, and impact on outcomes. BBMT. 2019;25:1395–1406.
  • Meng L, Zhai S-Z, Wang Y, et al. Class I and II human leukocyte antibodies in pediatric haploidentical allograft candidates: prevalence and risk factors. BMT. 2019;54:1287–1294.
  • Perez-Martinez A, Gonzalez-Vicent M, Valentin J, et al. Early evaluation of immune reconstitution following allogeneic CD3/CD19-depleted grafts from alternative donors in childhood acute leukemia. Bone Marrow Transplant. 2012;47:1419–1427.
  • Diaz MA, Pérez-Martínez A, Herrero B, et al. Prognostic factors and outcomes for pediatric patients receiving an haploidentical relative allogeneic transplant using CD3/CD19-depleted grafts. Bone Marrow Transplant. 2016;51(9):1211–1216.
  • Gonzalez-Vicent M, Perez A, Abad L, et al. Graft manipulation and reduced-intensity conditioning for allogeneic hematopietic stem cell transplantation from mismatched unrelated and mismatched/haploidentical related donors in pediatric leukemia patients. J Pediat Hematol Oncol. 2010; 32:85–90.
  • Locatelli F, Merli P, Pagliara D, et al. Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion. Blood. 2017;130(5):677–685.
  • Maschan M, Shelikhova L, Ilushina M, et al. TCR-alpha/beta and CD19 depletion and treosulfan-based conditioning regimen in unrelated and haploidentical transplantation in children with acute myeloid leukemia . Bone Marrow Transplant. 2016;51(5):668–674.
  • Diaz MA, Zubicaray J, Molina B, et al. Haploidentical stem cell transplantation in children with hematological malignancies using αβ(+) T-cell receptor and CD19(+) cell depleted grafts: high CD56(dim)/CD56(bright) NK cell ratio early following transplantation is associated with lower relapse incidence and better outcome. Front Immunol. 2019;10:2504.
  • Cooley S, Weisdorf DJ, Guethlein LA, et al. Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood. 2010;116(14):2411–2419.
  • Ciurea SO, Cao K, Fernandez-Vina M, et al. The European Society for Blood and Marrow Transplantation (EBMT) consensus guidelines for the detection and treatment of donor-specific anti-HLA antibodies (DSA) in haploidentical hematopoietic cell transplantation. Bone Marrow Transplant. 2018;53(5):521–534.
  • Sevilla J, Guillen M, Galvez E, et al. Immunomagnetic T cell depletion: an analysis of variables affecting final cell yield. Clin Lab. 2016;62(7):1243–1248.
  • Gray RJ. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Am Stat. 1988;16(3):1141–1154.
  • Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc. 1958;53(282):457–481.
  • Olsson R, Remberger M, Schaffer M, et al. Graft failure in the modern era of allogeneic hematopoietic SCT. Bone Marrow Transplant. 2013;48(4):537–543.
  • Olsson RF, Logan BR, Chaudhury S, et al. Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies. Leukemia. 2015;29(8):1754–1762.
  • Gonzalez-Vicent M, &, Perez MAD. Allogeneic hematopoietic stem-cell transplantation from haploidentical donor using ‘ex-vivo’ T-cell depletion in pediatric patients with hematological malignancies: state of the art review. Curr Opin Oncol. 2018; 30(6):396–401.
  • Booth C, Lawson S, Veys P. The current role of T cell depletion in paediatric stem cell transplantation. Br J Haematol. 2013;162(2):177–190.
  • Lang P, Teltschik H-M, Feuchtinger T, et al. Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia. Br J Haematol. 2014;165(5):688–698.
  • Lv M, Zhai SZ, Wang Y, et al. Class I and II human leukocyte antibodies in pediatric haploidentical allograft candidates: prevalence and risk factors. Bone Marrow Transplant. 2019;54(8):1287–1294.
  • Focosi D, Zucca A, Scatena F. The role of anti-HLA antibodies in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2011;17(11):1585–1588.
  • Baumeister SHC, Rambaldi B, Shapiro RM, et al. Key aspects of the immunobiology of haploidentical hematopoietic cell transplantation. Front Immunol. 2020;11:191.
  • Woodard P, Tong X, Richardson S, et al. Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipients. J Pediatr Hematol Oncol. 2003;25(12):955–959.
  • Ferrà C, Sanz J, Díaz-Pérez MA, for the Grupo Español de Trasplante Hematopoyético (Geth) Spanish Society of Hematology, et al. Outcome of graft-failure after allogeneic stem cell transplantation: study of 89 patients. Leuk Lymphoma. 2015;56(3):656–662.
  • Locatelli F, Lucarelli B, Merli P. Current and future approaches to treat graft failure after allogeneic hematopoietic stem cell transplantation. Expert Opin Pharmacother. 2014;15(1):23–36.
  • Rubio MT, Kim YM, Sachs T, et al. Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma. Blood. 2003;102(6):2300–2307.
  • Guardiola P, Kuentz M, Garban F, et al. French Society of Bone Marrow Transplantation. Second early allogeneic stem cell transplantations for graft failure in acute leukemia, chronic myeloid leukemia and aplastic anemia. Br J Haematol. 2000;111:292–302.
  • Rondon G, Saliba RM, Khouri I, et al. Long-term follow-up of patients who experienced graft failure postallogeneic progenitor cell transplantation. Results of a single institution analysis. Biol Blood Marrow Transplant. 2008;14(8):859–866.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.