421
Views
0
CrossRef citations to date
0
Altmetric
Original Articles

Combined use of adipose derived stem cells and TGF-β3 microspheres promotes articular cartilage regeneration in vivo

, , , , , & show all

References

  • Augustyniak E, Trzeciak T, Richter M, Kaczmarczyk J, Suchorska W (2015) The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration. Int. Orthop. 39: 995–1003.
  • Blaney EN, Van Caam AP, van der Kraan PM (2017) Osteoarthritis year in review 2016: biology. Osteoarthr. Cart. 25: 175–180.
  • Carbone A, Rodeo S (2017) Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries. J. Orthop. Res. 35: 397–405.
  • Chamberlain G, Fox J, Ashton B, Middleton J (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25: 2739–2749.
  • Chen G, Fang T, Qi Y, Yin X, Di T, Feng G, Lei Z, Zhang Y, Huang Z (2016) Combined use of mesenchymal stromal cell sheet transplantation and local injection of SDF-1 for bone repair in a rat non-union model. Cell Transplant. 25: 1801–1817.
  • Diekman BO, Guilak F (2013) Stem cell-based therapies for osteoarthritis: challenges and opportunities. Curr. Opin. Rheumatol. 25: 119.
  • Dinescu S, Galateanu B, Albu M, Cimpean A, Dinischiotu A, Costache M (2013) Sericin enhances the bioperformance of collagen-based matrices pre-seeded with human-adipose derived stem cells (hADSCs). Int. J. Mol. Sci. 14: 1870–1889.
  • Fan H, Hu Y, Qin L, Li X, Wu H, Lv R (2006) Porous gelatin-chondroitin-hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-β1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair. J. Biomed. Mater. Res. A77: 785–794.
  • Fan H, Zhang C, Li J, Bi L, Qin L, Wu H, Hu Y (2008) Gelatin microspheres containing TGF-β3 enhance the chondrogenesis of mesenchymal stem cells in modified pellet culture. Biomacromolecules 9: 927–934.
  • Fan H, Tao H, Wu Y, Hu Y, Yan Y, Luo Z (2010) TGF-β3 immobilized PLGA-gelatin/chondroitin sulfate/hyaluronic acid hybrid scaffold for cartilage regeneration. J. Biomed. Mater. Res. 95: 982–992.
  • Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, Tenen A (2016) Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy–a review. BMC Musculoskel. Disord. 17: 230–242.
  • Han Y, Wei Y, Wang S, Song Y (2010) Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres. Joint Bone Spine 77: 27–31.
  • Hiraoka Y, Yamashiro H, Yasuda K, Kimura Y, Inamoto T, Tabata Y (2006) In situ regeneration of adipose tissue in rat fat pad by combining a collagen scaffold with gelatin microspheres containing basic fibroblast growth factor. Tissue Eng. 12: 1475–1487.
  • Huang Z, Li J, Du S, Chen G, Qi Y, Huang L, Xiao L, Tong P (2016a) Effects of UCP4 on the proliferation and apoptosis of chondrocytes: its possible involvement and regulation in osteoarthritis. Plos One 11: e0150684.
  • Huang ZM, Du SH, Huang LG, Li JH, Xiao L, Tong P (2016b) Leptin promotes apoptosis and inhibits autophagy of chondrocytes through upregulating lysyl oxidase-like 3 during osteoarthritis pathogenesis. Osteoarthr. Cart. 24: 1246–1253.
  • Jang MY, Chun SI, Mun CW, Hong KS, Shin JW (2013) Evaluation of metabolomic changes as a biomarker of chondrogenic differentiation in 3D-cultured human mesenchymal stem cells using proton (1H) nuclear magnetic resonance spectroscopy. Plos One 8: e78325.
  • Jiang W, Wang H, Li YS, Luo W (2016) Role of vasoactive intestinal peptide in osteoarthritis. J. Biomed. Sci. 23: 63.
  • Kawamura K, Chu CR, Sobajima S, Robbins PD, Fu FH, Izzo NJ, Niyibizi C (2005) Adenoviral-mediated transfer of TGF-β1, but not IGF-1, induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. Exp. Hematol. 33: 865–872.
  • Lam XM, Duenas ET, Daugherty AL, Levin N, Clelanda JL (2000) Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J. Control Rel. 67: 281–292.
  • Lane NE, Shidara K, Wise BL (2017) Osteoarthritis year in review 2016: clinical. Osteoarthr. Cart. 25: 209–215.
  • Lee HL, Yu B, Deng P, Wang CY, Hong C (2016) Transforming growth factor-β-induced KDM4B promotes chondrogenic differentiation of human mesenchymal stem cells. Stem. Cells 34: 711–719.
  • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25: 402–408.
  • Makris EA, Gomoll AH, Malizos KN, Hu JC, Athanasiou KA (2015) Repair and tissue engineering techniques for articular cartilage. Nat. Rev. Rheumatol. 11: 21–34.
  • Mankin HJ, Dorfman H, Lippiello L, Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J. Bone Joint Surg. Am. 53: 523–537.
  • Moioli EK, Hong L, Guardado J, Clark PA, Mao JJ (2006) Sustained release of TGF β3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells. Tissue Eng. 12: 537–546.
  • Mumme M, Barbero A, Miot S, Wixmerten A, Feliciano S, Wolf F, Asnaghi AM, Baumhoer D, Bieri O, Kretzschmar M, Pagenstert G, Haug M, Schaefer DJ, Martin I, Jakob M (2016) Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet 388: 1985–1994.
  • Nejadnik H, Hui JH, Feng EP, Tai BC, Lee EH (2010) Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am. J. Sports Med. 38: 1110–1116.
  • Nishida A, Yamada M, Kanazawa T, Takashima Y, Ouchi K, Okada H (2011) Sustained-release of protein from biodegradable sericin film, gel and sponge. Int. J. Pharm. 407: 44–52.
  • Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB (2006) Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr. Cart. 14: 13–29.
  • Qi Y, Niu L, Zhao T, Shi Z, Di T, Feng G, Li J, Huang Z (2015) Combining mesenchymal stem cell sheets with platelet-rich plasma gel/calcium phosphate particles: a novel strategy to promote bone regeneration. Stem Cell Res. Ther. 6: 256–271.
  • Qiu B, Gong M, He QT, Zhou PH (2016) Controlled release of interleukin-1 receptor antagonist from hyaluronic acid-chitosan microspheres attenuates interleukin-1β-induced inflammation and apoptosis in chondrocytes. Biomed. Res. Int 2016: 6290957–6290968.
  • Rambhia KJ, Ma PX (2015) Controlled drug release for tissue engineering. J. Control Rel. 219: 119–128.
  • Richter DL, Tanksley JA, Miller MD (2016) Osteochondral autograft transplantation: a review of the surgical technique and outcomes. Sports Med. Arthrosc. 24: 74–78.
  • Skop NB, Calderon F, Levison SW, Gandhi CD, Cho CH (2013) Heparin crosslinked chitosan microspheres for the delivery of neural stem cells and growth factors for central nervous system repair. Acta Biomater. 9: 6834–6843.
  • Sofu H, Kockara N, Oner A, Camurcu Y, Issın A, Sahin V (2017) Results of hyaluronic acid-based cell-free scaffold application in combination with microfracture for the treatment of osteochondral lesions of the knee: 2-year comparative study. Arthroscopy 33: 209–216.
  • Tao K, Frisch J, Rey-Rico A, Venkatesan JK, Schmitt G, Madry H, Lin J, Cucchiarini M (2016) Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells. Stem Cell Res. Ther. 7: 20–31.
  • Thamake SI, Raut SL, Ranjan AP, Gryczynski Z, Vishwanatha JK (2011) Surface functionalization of PLGA nanoparticles by non-covalent insertion of a homo-bifunctional spacer for active targeting in cancer therapy. Nanotechnology 22: 035101–035110.
  • Thorpe SD, Buckley CT, Vinardell T, O’Brien FJ, Campbell VA, Kelly DJ (2010) The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation. Ann. Biomed. Eng. 38: 2896–2909.
  • Toupet K, Maumus M, Luz-Crawford P, Lombardo E, Lopez-Belmonte J, Van Lent P, Garin MI, van den Berg W, Dalemans W, Jorgensen C, Noël D (2015) Survival and biodistribution of xenogenic adipose mesenchymal stem cells is not affected by the degree of inflammation in arthritis. Plos One 10: e0114962.
  • Yang SE, Ha CW, Jung MH, Jin HJ, Lee MK, Song HS, Choi SJ, Oh W, Yang YS (2004) Mesenchymal stem/progenitor cells developed in cultures from UC blood. Cytotherapy 6: 476–486.
  • Yuksel E, Weinfeld AB, Cleek R, Wamsley S, Jensen J, Boutros S, Waugh JM, Shenaq SM, Spira M (2000) Increased free fat-graft survival with the long-term, local delivery of insulin, insulin-like growth factor-I, and basic fibroblast growth factor by PLGA/PEG microspheres. Plast. Reconstr. Surg. 105: 1712–1720.
  • Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH (2002) Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell. 13: 4279–4295.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.