366
Views
10
CrossRef citations to date
0
Altmetric
Articles

Immunohistochemical analysis and comparison of napsin A, TTF1, SPA and CK7 expression in primary lung adenocarcinoma

, , &

References

  • Asami K, Atagi S (2014) Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer. World J. Clin. Oncol. 5: 646–659.
  • Fatima N, Cohen C, Lawson D, Siddiqui MT (2011) TTF-1 and napsin A double stain: a useful marker for diagnosing lung adenocarcinoma on fine-needle aspiration cell blocks. Cancer Cytopathol. 119: 127–133.
  • Kaufmann O, Dietel M (2000) Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology 36: 8–16.
  • Koo CL, Kok LF, Lee MY, Wu TS, Cheng YW, Hsu JD, Ruan A, Chao KC, Han CP (2009) Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. J. Transl. Med. 7: 25.
  • Lee JG, Kim S, Shim HS (2012) Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung. Lung Cancer 77: 156–161.
  • Mukhopadhyay S, Katzenstein AL (2011) Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am. J. Surg. Pathol. 35: 15–25.
  • Noh S, Shim H (2012) Optimal combination of immunohistochemical markers for subclassification of non-small cell lung carcinomas: a tissue microarray study of poorly differentiated areas. Lung Cancer 76: 51–55.
  • Pelosi G, Fraggetta F, Pasini F, Maisonneuve P, Sonzogni A, Iannucci A, Terzi A, Bresaola E, Valduga F, Lupo C, Viale G (2001) immunoreactivity for thyroid transcription factor-1 in stage non-small cell carcinomas of the lung. Am. J. Surg. Pathol. 25: 363–372.
  • Qi W, Chu J, Zhou D, Tacha D (2009) Characterization and applications of a newly developed rabbit monoclonal antibody to cytokeratin 7 (CK7) for immunohistochemistry. Appl. Immunohistochem. Mol. Morphol. 17: 233–238.
  • Rekhtman N, Ang DC, Sima CS, Travis WD, Moreira AL (2011) Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole tissue sections with validation in small specimens. Mod. Pathol. 24: 1348–1359.
  • Serpil O, Meral A, Müzeyyen O, Ozlem T, Umit Y, Mustafa T (2009) Alkaline phosphatase, cytokeratin 7, cytokeratin 8 in the diagnosis of primary lung adenocarcinoma from 148 pleura fluids specimens. Fol. Histochem. Cytobiol. 47: 87–92.
  • Stoll LM, Johnson MW, Gabrielson E, Askin F, Clark DP, Li QK (2010) The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas. Cancer Cytopathol. 118: 441–449.
  • Torre LA, Siegel RL, Jemal A (2016) Lung cancer statistics. Adv. Exp. Med. Biol. 893: 1–19.
  • Turner BM, Cagle PT, Sainz IM, Fukuoka J, Shen SS, Jagirdar J (2012) Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray. Arch. Pathol. Lab. Med. 136: 163–171.
  • Xu XY, Yang GY, Yang JH, Li J (2014) Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34βE12, p63, CK7 and TTF-1. Pathol. Res. Pract. 210: 680–685.
  • Ye J, Hameed O, Findeis-Hosey JJ, Fan L, Li F, McMahon LA, Yang Q, Wang HL, Xu H (2012) Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung. Biotech. & Histochem. 87: 30–34.
  • Zamecnik J, Kodet R (2002) Value of thyroid transcription factor-1 and surfactant apoprotein A in the differential diagnosis of pulmonary carcinomas: a study of 109 cases. Virchows Arch. 440: 353–361.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.