Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats

References

• Abd El-Twab SM, Hozayen WG, Hussein OE, Mahmoud AM. 2016. 18β-glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants. Ren Fail. 38:1516–1527. doi: 10.1080/0886022X.2016.1216722.
   PubMed Web of Science ®Google Scholar
• Abdel-Wahhab A, Nada SA, Arbid MS. 1999. Ochratoxicosis: prevention of developmental toxicity by L-methionine in rats m. J Appl Toxicol. 19:7–12. doi: 10.1002/(SICI)1099-1263(199901/02)19:1<7:AID-JAT529>3.0.CO;2-G.
   PubMed Web of Science ®Google Scholar
• Acar R, Karadurmus N, Koc B. 2020. Analysis of tissue cytokine levels in rats with cisplatin-induced experimental nephrotoxicity. EJMI. 4:376–379. doi: 10.14744/ejmi.2020.36703.
   Google Scholar
• Aebi H. 1984. Catalase. Methods Enzymol. 105:121–126.
   PubMed Web of Science ®Google Scholar
• Akdemir FNE, Yildirim S, Kandemir FM, Gülçin I, Küçükler S, Sağlam YS, Yakan S. 2018. The effects of casticin and myricetin on liver damage induced by methotrexate in rats. Iran J Basic Med Sci. 21:1281–1288. doi: 10.22038/ijbms.2018.29922.7217.
   PubMed Web of Science ®Google Scholar
• Akkoyun HT. 2019. The protective effect of quercetin against to renal tissue damage induced carbontetrachloride in rat. JIST. 9:708–716. doi: 10.21597/jist.475524.
   Google Scholar
• Alam M, Ali S, Mohammad T, Hasan GM, Yadav DK, Hassan MI. 2021. B cell lymphoma 2: a potential therapeutic target for cancer therapy. Int J Mol Sci. 22:10442. doi: 10.3390/ijms221910442.
   PubMed Web of Science ®Google Scholar
• Ali N, Rashid S, Nafees S, Hasan SK, Shahid A, Majed F, Sultana S. 2017. Protective effect of chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: an experimental approach. Chem Biol Interact. 272:80–91. doi: 10.1016/j.cbi.2017.05.002.
   PubMed Web of Science ®Google Scholar
• Asci H, Ozmen O, Ellidag HY, Aydin B, Bas E, Yilmaz N. 2017. The impact of gallic acid on the methotrexate-induced kidney damage in rats. J Food Drug Anal. 25:890–897. doi: 10.1016/j.jfda.2017.05.001.
   PubMed Web of Science ®Google Scholar
• Beutler E. 1971. Red cell metabolism. In: A manual of biochemical methods. Academic Press, London; p. 68–70.
   Google Scholar
• Beutler E. 1975. Red cell metabolism. In: A manual of biochemical methods. Grune Strottan, New York, NY; p. 67–69.
   Google Scholar
• Bozkurt M, Bodakci MN, Turkcu G, Kuyumcu M, Akkurt M, Sula B, Em S, Oktayoglu P, Batmaz I, Yüksel H. 2014a. Protective effects of carvacrol against methotrexate-induced liver toxicity in rats. Acta Chir Belg. 114:404–409. doi: 10.1080/00015458.2014.11681052.
   PubMed Web of Science ®Google Scholar
• Bozkurt M, Em S, Oktayoglu P, Turkcu G, Yuksel H, Sarıyıldız MA, Caglayan M, Batmaz I, Nas K, Bozkurt Y, Kuyumcu M. 2014b. Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats. Clin Invest Med. 37:E19–E25. doi: 10.25011/cim.v37i1.20865.
   PubMed Web of Science ®Google Scholar
• Cetiner M, Sener G, Sehirli AO, Eksioglu-Demiralp E, Ercan F, Sirvanci S, Gedik N, Akpulat S, Tecimer T, Yegen BC. 2005. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol Appl Pharmacol. 209:39–50. doi: 10.1016/j.taap.2005.03.009.
   PubMed Web of Science ®Google Scholar
• Chen J, Creed A, Chen AY, Huang H, Li Z, Rankin GO, Ye X, Xu G, Chen YC. 2014. Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells. BMC Pharmacol Toxicol. 24:59. doi: 10.1186/2050-6511-15-59.
   Google Scholar
• Dar AA, Fehaid A, Alkhatani S, Alarifi S, Alqahtani WS, Albasher G, Almeer R, Alfarraj S, Moneim AA. 2021. The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats. Hum Exp Toxicol. 40:1194–1207. doi: 10.1177/0960327121991905.
   PubMed Web of Science ®Google Scholar
• El-Sheikh AA, Morsy MA, Abdalla AM, Hamouda AH, Alhaider IA. 2015. Mechanisms of thymoquinone hepatorenal protection in methotrexate-induced toxicity in rats. Mediators Inflamm. 2015:859383. doi: 10.1155/2015/859383.
   PubMed Web of Science ®Google Scholar
• Ellman G. 1959. Tissue sulphydryl groups. Arch Biochem Biophys. 82:70–77. doi: 10.1016/0003-9861(59)90090-6.
   PubMed Web of Science ®Google Scholar
• Erdogan E, Ilgaz Y, Gurgor PN, Oztas Y, Topal T, Oztas E. 2015. Rutin ameliorates methotrexate induced hepatic injury in rats. Acta Cir Bras. 30:778–784. doi: 10.1590/S0102-865020150110000009.
   PubMed Web of Science ®Google Scholar
• Hafez HM, Ibrahim MA, Ibrahim SA, Amin EF, Goma W, Abdelrahman AM. 2015. Potential protective effect of etanercept and aminoguanidine in methotrexate-induced hepatotoxicity and nephrotoxicity in rats. Eur J Pharmacol. 768:1–12. doi: 10.1016/j.ejphar.2015.08.047.
   PubMed Web of Science ®Google Scholar
• Hassanein EHM, Shalkami AGS, Khalaf MM, Mohamed WR, Hemeida RAM. 2019. The impact of Keap1/Nrf2, P 38 MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity. Biomed Pharmacother. 109:47–56. doi: 10.1016/j.biopha.2018.10.088.
   PubMed Web of Science ®Google Scholar
• Huang H, Li L, Shi W, Liu H, Yang J, Yuan X, Wu L. 2016. The multifunctional effects of nobiletin and its metabolites in vivo and in vitro. Evid Based Complement Alternat Med. 2016:2918796. doi: 10.1155/2016/2918796.
   PubMed Web of Science ®Google Scholar
• Iyer SS, Cheng G. 2012. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 32:23–63. doi: 10.1615/CritRevImmunol.v32.i1.30.
   PubMed Web of Science ®Google Scholar
• Kazak F, Akalın PP, Yarım GF, Başpınar N, Özdemir Ö, Ateş MB, Altuğ ME, Deveci MZY. 2021. Protective effects of nobiletin on cisplatin induced neurotoxicity in rats. Int J Neurosci. 132:531–537. doi: 10.1080/00207454.2021.1896507.
   Web of Science ®Google Scholar
• Khoshnoud S, Mohseni KH, Nabiuni M. 2017. Evaluation of the protective effect of hydro-alcoholic extract of raspberry fruit on aquaporin1 expression in rats kidney treated by methotrexate. Cell J. 19:306–313. doi: 10.22074/cellj.2016.3957.
   PubMed Web of Science ®Google Scholar
• Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. 2012. Dietary L-arginine supplementation reduces methotrexate-induced intestinal mucosal injury in rat. BMC Gastroenterol. 12:41. doi: 10.1186/1471-230X-12-41.
   PubMed Web of Science ®Google Scholar
• Li W, Wang X, Niu X, Zhang H, He Z, Wang Y, Zhi W, Liu F. 2016. Protective effects of nobiletin against endotoxic shock in mice through inhibiting TNF-α, IL-6, and HMGB1 and regulating NF-κB pathway. Inflammation. 39:786–797. doi: 10.1007/s10753-016-0307-5.
   PubMed Web of Science ®Google Scholar
• Liedtke C, Trautwein C. 2012. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. Eur J Cell Biol. 91:582–589. doi: 10.1016/j.ejcb.2011.10.001.
   PubMed Web of Science ®Google Scholar
• Liu CM, Ma JQ, Sun YZ. 2010. Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead. Environ Toxicol Pharmacol. 30:264–271. doi: 10.1016/j.etap.2010.07.002.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with pholin phenol reagent. J Biol Chem. 193:265–275. doi: 10.1016/S0021-9258(19)52451-6.
   PubMed Web of Science ®Google Scholar
• Luna LG. 1968. Manual of histologic staining methods of the Armed Forces Institute of Pathology. 3rd ed. McGraw-Hill, New York, NY; p. 36–38.
   Google Scholar
• Maestá I, Nitecki R, Horowitz NS, Goldstein DP, Moreira MFS, Elias KM, Berkowitz RS. 2018. Effectiveness and toxicity of first-line methotrexate chemotherapy in low-risk postmolar gestational trophoblastic neoplasia: the New England trophoblastic disease center experience. Gynecol Oncol. 148:161–167. doi: 10.1016/j.ygyno.2017.10.028.
   PubMed Web of Science ®Google Scholar
• Mahmoud AM, Germoush MO, Al-Anazi KM, Mahmoud AH, Farah MA, Allam AA. 2018. Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling. Biomed Pharmacother. 106:499–509. doi: 10.1016/j.biopha.2018.06.171.
   PubMed Web of Science ®Google Scholar
• Mahmoud AM, Hozayen WG, Ramadan SM. 2017. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats. Biomed Pharmacother. 94:280–291. doi: 10.1016/j.biopha.2017.07.101.
   PubMed Web of Science ®Google Scholar
• Malayeri A, Badparva R, Mombeini MA, Khorsandi L, Goudarzi M. 2020. Naringenin: a potential natural remedy against methotrexate-induced hepatotoxicity in rats. Drug Chem Toxicol. 28:1–8. doi: 10.1080/01480545.2020.1719132.
   Google Scholar
• Malik S, Bhatia J, Suchal K, Gamad N, Dinda AK, Gupta YK, Arya DS. 2015. Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects. Exp Toxicol Pathol. 67:427–433. doi: 10.1016/j.etp.2015.04.008.
   PubMed Web of Science ®Google Scholar
• Minamiyama Y, Takemura S, Toyokuni S, Nishino Y, Yamasaki K, Hai S, Yamamoto S, Okada S. 2002. Amelioration of cisplatin toxicity by a fermented grain food product. Biofactors. 16:105–115. doi: 10.1002/biof.5520160306.
   PubMed Web of Science ®Google Scholar
• Moghadam AR, Tutunchi S, Namvaran-Abbas-Abad A, Yazdi M, Bonyadi F, Mohajeri D, Mazani M, Marzban H, Łos MJ, Ghavami S. 2015. Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress. BMC Complement Altern Med. 15:246. doi: 10.1186/s12906-015-0773-6.
   PubMed Web of Science ®Google Scholar
• Nouri HS, Azarmi Y, Movahedin M. 2009. Effect of growth hormone on testicular dysfunction induced by methotrexate in rats. Andrologia. 41:105–110. doi: 10.1111/j.1439-0272.2008.00897.x.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:351–358. doi: 10.1016/0003-2697(79)90738-3.
   PubMed Web of Science ®Google Scholar
• Olayinka ET, Ore A, Adeyemo OA, Ola OS. 2016. Ameliorative effect of gallic acid on methotrexate-induced hepatotoxicity and Nephrotoxicity in rat. J Xenobiot. 6:6092. doi: 10.4081/xeno.2016.6092.
   PubMed Web of Science ®Google Scholar
• Rao P, Hayden MS, Long M, Scott ML, West AP, Zhang D, Oeckinghaus A, Lynch C, Hoffmann A, Baltimore D, Ghosh S. 2010. Ikappa B beta acts to inhibit and activate gene expression during the inflammatory response. Nature. 466:1115–1119. doi: 10.1038/nature09283.
   PubMed Web of Science ®Google Scholar
• Sanchez M, Roussel R, Hadjadj S, Moutairou A, Marre M, Velho G, Mohammedi K. 2018. Plasma concentrations of 8-hydroxy-2'-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes. Diabetologia. 61:977–984. doi: 10.1007/s00125-017-4510-1.
   PubMedGoogle Scholar
• Sato S, Yamamoto E, Niimi K, Ino K, Nishino K, Suzuki S, Kotani T, Kajiyama H, Kikkawa F. 2020. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia. Int J Clin Oncol. 25:203–209. doi: 10.1007/s10147-019-01540-9.
   PubMed Web of Science ®Google Scholar
• Sener G, Ekşioğlu-Demiralp E, Çetiner M, Ercan F, Şirvancı S, Gedik N, Yeğen BÇ. 2006. L-carnitine ameliorates methotrexate-induced oxidative organ injury and inhibits leukocyte death. Cell Biol Toxicol. 22:47–60. doi: 10.1007/s10565-006-0025-0.
   PubMed Web of Science ®Google Scholar
• Sezen H, Yücel Y, Koçarslan S, Savik E, Bilinç H, Aksoy N. 2016. Melatonin-lycopene combination improves methotrexate-induced liver toxicity in rats via anti-inflammatory effect. Gaziantep Med J. 22:129–135. doi: 10.5152/EurJTher.2016.004.
   Google Scholar
• Sherif IO, Al-Shaalan NH, Sabry D. 2019. Ginkgo biloba extract alleviates methotrexate-induced renal injury: new impact on PI3K/Akt/mTOR signaling and MALAT1 expression. Biomolecules. 9:691. doi: 10.3390/biom9110691.
   PubMed Web of Science ®Google Scholar
• Thornberry NA, Lazebnik Y. 1998. Caspases: enemies within. Science. 281:1312–1316. doi: 10.1126/science.281.5381.1312.
   PubMed Web of Science ®Google Scholar
• Tsai JP, Liou JH, Yeh KT, Tai HC, Cheng YW, Chang HR. 2011. Intensity of cytosol expression of 8-OHdG in normal renal tubules is associated with the severity of renal fibrosis. Swiss Med Wkly. 141:w13268. doi: 10.4414/smw.2011.13268.
   PubMed Web of Science ®Google Scholar
• Vardi N, Parlakpinar H, Ozturk F, Ates B, Gul M, Cetin A, Erdogan A, Otlu A. 2008. Potent protective effect of apricot and b-carotene on methotrexate-induced intestinal oxidative damage in rats. Food Chem Toxicol. 46:3015–3022. doi: 10.1016/j.fct.2008.05.039.
   PubMed Web of Science ®Google Scholar
• Vonen B, Mørland J. 1984. Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs. Arch Toxicol. 56:33–37. doi: 10.1007/BF00316349.
   PubMed Web of Science ®Google Scholar
• Wang YM, Du GQ. 2016. Glycyrrhizic acid prevents enteritis through reduction of NF-κB p65 and p38MAPK expression in rat. Mol Med Rep. 13:3639–3646. doi: 10.3892/mmr.2016.4981.
   PubMed Web of Science ®Google Scholar
• Wei D, Zhang G, Zhu Z, Zheng Y, Yan F, Pan C, Wang Z, Li X, Wang F, Meng P, Zheng W, Yan Z, Zhai D, Lu Z, Yuan J. 2019. Nobiletin inhibits cell viability via the SRC/AKT/STAT3/YY1AP1 pathway in human renal carcinoma cells. Front Pharmacol. 10:690. doi: 10.3389/fphar.2019.00690.
   PubMed Web of Science ®Google Scholar
• Widemann BC, Adamson PC. 2006. Understanding and managing methotrexate nephrotoxicity. Oncologist. 11:694–703. doi: 10.1634/theoncologist.11-6-694.
   PubMed Web of Science ®Google Scholar
• Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S, Bacci G, Craft AW, Adamson PC. 2004. High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma: incidence, treatment, and outcome. Cancer. 100:2222–2232. doi: 10.1002/cncr.20255.
   PubMed Web of Science ®Google Scholar
• Yeo CM, Chong VH, Earnest A, Yang WL. 2013. Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis. World J Hepatol. 5:275–280. doi: 10.4254/wjh.v5.i5.275.
   PubMedGoogle Scholar
• Yoshigai E, Machida T, Okuyama T, Mori M, Murase H, Yamanishi R, Okumura T, Ikeya Y, Nishino H, Nishizawa M. 2013. Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes. Biochem Biophys Res Commun. 439:54–59. doi: 10.1016/j.bbrc.2013.08.029.
   PubMed Web of Science ®Google Scholar
• Yucel Y, Oguz E, Kocarslan S, Tatli F, Gozeneli O, Seker A, Sezen H, Buyukaslan H, Aktumen A, Ozgonul A, Uzunkoy A, Aksoy N. 2017. The effects of lycopene on methotrexate-induced liver injury in rats. Bratisl Lek Listy. 118:212–216. doi: 10.4149/BLL_2017_042.
   PubMed Web of Science ®Google Scholar
• Yuksel Y, Yuksel R, Yagmurca M, Haltas H, Erdamar H, Toktas M, Ozcan O. 2017. Effects of quercetin on methotrexate-induced nephrotoxicity in rats. Hum Exp Toxicol. 36:51–61. doi: 10.1177/0960327116637414.
   PubMed Web of Science ®Google Scholar
• Zhou H, Kato A, Miyaji T, Yasuda H, Fujigaki Y, Yamamoto T, Yonemura K, Takebayashi S, Mineta H, Hishida A. 2006. Urinary marker for oxidative stress in kidneys in cisplatin-induced acute renal failure in rats. Nephrol Dial Transplant. 21:616–623. doi: 10.1093/ndt/gfi314.
   PubMed Web of Science ®Google Scholar