100
Views
0
CrossRef citations to date
0
Altmetric
Articles

Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis

ORCID Icon, , , , , & show all

References

  • Ahmed OAA, Fahmy UA, Bakhaidar R, El-Moselhy MA, Alfaleh MA, Ahmed AF, Hammad ASA, Aldawsari H, Alhakamy NA. 2020. Pumpkin oil-based nanostructured lipid carrier system for antiulcer effect in NSAID-Induced gastric ulcer model in rats. Int J Nanomed. 15:2529–2539. doi: 10.2147/IJN.S247252.
  • Arakawa T, Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Morimoto K. 2012. Quality of ulcer healing in gastrointestinal tract: its pathophysiology and clinical relevance. World J Gastroenterol. 18:4811–4822. doi: 10.3748/wjg.v18.i35.4811.
  • Becker JC, Domschke W, Pohle T. 2004. Current approaches to prevent NSAID-induced gastropathy–COX selectivity and beyond. Br J Clin Pharmacol. 58:587–600. doi: 10.1111/j.1365-2125.2004.02198.x.
  • Brzozowska I, Targosz A, Sliwowski Z, Kwiecien S, Drozdowicz D, Pajdo R, Konturek PC, Brzozowski T, Pawlik M, Konturek SJ, Pawlik WW. 2004. Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. J Physiol Pharmacol. 55:773–790.
  • Cao Y, Zhang L, Sun S, Yi Z, Jiang X, Jia D. 2016. Neuroprotective effects of syringic acid against OGD/R-induced injury in cultured hippocampal neuronal cells. Int J Mol Med. 38:567–573. doi: 10.3892/ijmm.2016.2623.
  • Chang X, Luo F, Jiang W, Zhu L, Gao J, He H, Wei T, Gong S, Yan T. 2015. Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK/NF-kappaB pathway in vivoand in vitro. Int Immunopharmacol. 28:604–615. doi: 10.1016/j.intimp.2015.07.031.
  • Cikman O, Soylemez O, Ozkan OF, Kiraz HA, Sayar I, Ademoglu S, Taysi S, Karaayvaz M. 2015. Antioxidant activity of syringic acid prevents oxidative stress in l-arginine-induced acute pancreatitis: an experimental study on rats. Int Surg. 100:891–896. doi: 10.9738/INTSURG-D-14-00170.1.
  • El-Ashmawy NE, Khedr EG, El-Bahrawy HA, Selim HM. 2016. Nebivolol prevents indomethacin-induced gastric ulcer in rats. J Immunotoxicol. 13:580–589. doi: 10.3109/1547691X.2016.1142488.
  • Enders G, Brooks W, von Jan N, Lehn N, Bayerdorffer E, Hatz R. 1995. Expression of adhesion molecules on human granulocytes after stimulation with Helicobacter pylori membrane proteins: comparison with membrane proteins from other bacteria. Infect Immun. 63:2473–2477. doi: 10.1128/iai.63.7.2473-2477.1995.
  • Fornai M, Colucci R, Antonioli L, Ghisu N, Tuccori M, Blandizzi C, Del Tacca M. 2009. Effects of pantoprazole on ulcer healing delay associated with NSAID treatment. Naunyn Schmiedebergs Arch Pharmacol. 379:305–313. doi: 10.1007/s00210-008-0355-y.
  • Gardiner TA, Gibson DS, de Gooyer TE, de la Cruz VF, McDonald DM, Stitt AW. 2005. Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy. Am J Pathol. 166:637–644. doi: 10.1016/S0002-9440(10)62284-5.
  • Gudis K, Sakamoto C. 2005. The role of cyclooxygenase in gastric mucosal protection. Dig Dis Sci. 50:S16–23. doi: 10.1007/s10620-005-2802-7.
  • Guha P, Dey A, Chatterjee A, Chattopadhyay S, Bandyopadhyay SK. 2010. Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine. Br J Pharmacol. 159:726–734. doi: 10.1111/j.1476-5381.2009.00572.x.
  • Guven M, Aras AB, Topaloglu N, Ozkan A, Sen HM, Kalkan Y, Okuyucu A, Akbal A, Gokmen F, Cosar M. 2015. The protective effect of syringic acid on ischemia injury in rat brain. Turk J Med Sci. 45:233–240. doi: 10.3906/sag-1402-71.
  • Haastrup PF, Thompson W, Sondergaard J, Jarbol DE. 2018. Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharmacol Toxicol. 123:114–121. doi: 10.1111/bcpt.13023.
  • Heidelbaugh JJ. 2013. Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications. Ther Adv Drug Saf. 4:125–133. doi: 10.1177/2042098613482484.
  • Jeong HY, Choi YS, Lee JK, Lee BJ, Kim WK, Kang H. 2017. Anti-inflammatory activity of citric acid-treated wheat germ extract in lipopolysaccharide-stimulated macrophages. Nutrients. 9:730. doi: 10.3390/nu9070730.
  • Ji J, Yang X, Flavel M, Shields ZP, Kitchen B. 2019. Antioxidant and anti-diabetic functions of a polyphenol-rich sugarcane extract. J Am Coll Nutr. 38:670–680. doi: 10.1080/07315724.2019.1587323.
  • Ko IG, Jin JJ, Hwang L, Kim SH, Kim CJ, Han JH, Kwak MS, Yoon JY, Jeon JW. 2020. Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-kappaB signaling pathway in rats. Eur J Pharmacol. 874:172952. doi: 10.1016/j.ejphar.2020.172952.
  • Kumar S, Prahalathan P, Raja B. 2012. Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 385:1175–1184. doi: 10.1007/s00210-012-0802-7.
  • Leung AY, Leung JC, Chan LY, Ma ES, Kwan TT, Lai KN, Meng A, Liang R. 2005. Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis. Histochem Cell Biol. 124:105–111. doi: 10.1007/s00418-005-0003-2.
  • Lim JH, Kim JH, Kim N, Lee BH, Seo PJ, Kang JM, Jo SY, Park JH, Nam RH, Chang H, Kwon J-W, Lee DH, et al. 2014. Gastroprotective effect of Cochinchina momordica seed extract in nonsteroidal anti-inflammatory drug-induced acute gastric damage in a rat model. Gut Liver. 8:49–57. doi: 10.5009/gnl.2014.8.1.49.
  • Liu G, Zhang BF, Hu Q, Liu XP, Chen J. 2020. Syringic acid mitigates myocardial ischemia reperfusion injury by activating the PI3K/Akt/GSK-3beta signaling pathway. Biochem Biophys Res Commun. 531:242–249. doi: 10.1016/j.bbrc.2020.07.047.
  • Liu J, Wang F, Luo H, Liu A, Li K, Li C, Jiang Y. 2016. Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms. Int Immunopharmacol. 30:179–187. doi: 10.1016/j.intimp.2015.11.018.
  • Milani S, Calabro A. 2001. Role of growth factors and their receptors in gastric ulcer healing. Microsc Res Tech. 53:360–371. doi: 10.1002/jemt.1104.
  • Mirza AC, Panchal SS. 2019. Safety evaluation of syringic acid: subacute oral toxicity studies in Wistar rats. Heliyon. 5:e02129. doi: 10.1016/j.heliyon.2019.e02129.
  • Mohan S, Hobani YH, Shaheen E, Abou-Elhamd AS, Abdelhaleem A, Alhazmi HA, Abdelwahab SI. 2020. Girinimbine from curry leaves promotes gastro protection against ethanol induced peptic ulcers and improves healing via regulation of anti-inflammatory and antioxidant mechanisms. Food Funct. 11:3493–3505. doi: 10.1039/D0FO00053A.
  • Musumba C, Pritchard DM, Pirmohamed M. 2009. Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther. 30:517–531. doi: 10.1111/j.1365-2036.2009.04086.x.
  • Okkay U, Ferah Okkay I, Cicek B, Aydin IC, Ertugrul MS, Bayram C, Senyayla S, Sezen S, Mendil AS, Guven L, Hacimuftuoglu A, et al. 2021. Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses. Andrologia. 53: E14028 doi: 10.1111/and.14028.
  • Periyannan V, Veerasamy V. 2018. Syringic acid may attenuate the oral mucosal carcinogenesis via improving cell surface glycoconjugation and modifying cytokeratin expression. Toxicol Rep. 5:1098–1106. doi: 10.1016/j.toxrep.2018.10.015.
  • Rashedinia M, Alimohammadi M, Shalfroushan N, Khoshnoud MJ, Mansourian M, Azarpira N, Sabahi Z. 2020. Neuroprotective effect of syringic acid by modulation of oxidative stress and mitochondrial mass in diabetic rats. Biomed Res Int. 2020:8297984. doi: 10.1155/2020/8297984.
  • Scarpignato C, Hunt RH. 2010. Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention. Gastroenterol Clin North Am. 39:433–464. doi: 10.1016/j.gtc.2010.08.010.
  • S M, Shaik AH, E MP, Al Omar SY, Mohammad A, Kodidhela LD. 2020. Combined cardio-protective ability of syringic acid and resveratrol against isoproterenol induced cardio-toxicity in rats via attenuating NF-kB and TNF-alpha pathways. Sci Rep. 10:3426. doi: 10.1038/s41598-020-59925-0.
  • Shi C, Sun Y, Zheng Z, Zhang X, Song K, Jia Z, Chen Y, Yang M, Liu X, Dong R, Xia X, et al. 2016. Antimicrobial activity of syringic acid against Cronobacter sakazakii and its effect on cell membrane. Food Chem. 197:100–106. doi: 10.1016/j.foodchem.2015.10.100.
  • Srinivasulu C, Ramgopal M, Ramanjaneyulu G, Anuradha CM, Suresh Kumar C. 2018. Syringic acid (SA) ‒ a review of its occurrence, biosynthesis, pharmacological and industrial importance. Biomed Pharmacother. 108:547–557. doi: 10.1016/j.biopha.2018.09.069.
  • Takeuchi K. 2012. Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility. World J Gastroenterol. 18:2147–2160. doi: 10.3748/wjg.v18.i18.2147.
  • Tarnawski AS. 2005. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci. 50:S24–33. doi: 10.1007/s10620-005-2803-6.
  • Tokmak M, Sehitoglu MH, Yuksel Y, Guven M, Akman T, Aras AB, Yaka U, Gomleksiz C, Albayrak SB, Cosar M. 2017. The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model. Turk Neurosurg. 27:124–132. doi: 10.5137/1019-5149.JTN.14656-15.5.
  • Wallace JL. 2001. Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Mechanisms of protection and healing: current knowledge and future research. Am J Med. 110:19S–23S. doi: 10.1016/S0002-9343(00)00631-8.
  • Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Bohm M, Nickenig G. 2004. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res. 94:534–541. doi: 10.1161/01.RES.0000115557.25127.8D.
  • Watanabe T, Higuchi K, Hamaguchi M, Shiba M, Tominaga K, Fujiwara Y, Matsumoto T, Arakawa T. 2004. Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha. Am J Physiol Gastrointest Liver Physiol. 287:G919–928. doi: 10.1152/ajpgi.00372.2003.
  • Xiao X, Nakatsu G, Jin Y, Wong S, Yu J, Lau JY. 2017. Gut microbiota mediates protection against enteropathy induced by indomethacin. Sci Rep. 7:40317. doi: 10.1038/srep40317.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.