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Articles

Ameliorative effects of Myrtus communis L. extract involving the inhibition of oxidative stress on high fat diet-induced testis damage in rats

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References

  • Abidli N, Ghaly I, Hassanane MM, Ahmed ES, Khalil WKB. 2015. Myrtus species prevents reproductive toxicity induced by doxorubicin in male mice. Asian J Pharm Clin Res. 8:169–175.
  • Açikel-Elmas M, Arbak S, Ercan F. 2019a. Ameliorating effects of exercise on disrupted epididymal sperm parameters in high fat diet-induced obese rats. Marmara Med J. 32:14–19. doi: 10.5472/marumj.518732.
  • Açikel-Elmas M, Cakıcı SE, Dur IR, Kozluca I, Arınc M, Binbuga B, Ozakpınar OB, Kolgazi M, Sener G, Ercan F. 2019b. Protective effects of exercise on heart and aorta in high-fat diet-induced obese rats. Tissue Cell. 57:57–65. doi: 10.1016/j.tice.2019.01.005.
  • Ahmed AH. 2013. Flavonoid content and antiobesity activity of leaves of Myrtus communis. Asian J Chem. 25:6818–6822. doi: 10.14233/ajchem.2013.14823.
  • Alshahrani S, Ahmed A-F, Gabr AH, Abalhassan M, Ahmad G, Gabr CHA. 2016. The impact of body mass index on semen parameters in infertile men. Andrologia. 48:1125–1129. doi: 10.1111/and.12549.
  • Aslankoc R, Ozmen O. 2019. The effects of high-fructose corn syrup consumption on testis physiopathology—The ameliorative role of melatonin. Andrologia. 51:e13327. doi: 10.1111/and.13327.
  • Aykac A, Ozbeyli D, Uncu M, Ertaş B, Kılınc O, Şen A, Orun O, Sener G. 2019. Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors. Gene. 689:194–201. doi: 10.1016/j.gene.2018.12.007.
  • Blokhina O, Virolainen E, Fagerstedt KV. 2003. Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot. 91:179–194. doi: 10.1093/aob/mcf118.
  • Contini A, Bello DD, Azzarà A, Giovanelli S, D’Urso G, Piaggi S, Pinto B, Pistelli L, Scarpato R, Testi S. 2020. Assessing the cytotoxic/genotoxic activity and estrogenic/antiestrogenic potential of essential oils from seven aromatic plants. Food Chem Toxicol. 138:111205. doi: 10.1016/j.fct.2020.111205.
  • de Lima DCD, Silveira SA, Haibara AS, Coimbra CC. 2008. The enhanced hyperglycemic response to hemorrhage hypotension in obese rats is related to an impaired baroreflex. Metab Brain Dis 23:361–373. doi:10.1007/s11011-008-9101-x.
  • Du Plessis SSD, Cabler S, McAlister DA, Sabanegh E, Agarwal A. 2010. The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 7:153–161. doi: 10.1038/nrurol.2010.6.
  • Elmas MA, Ozakpinar OB, Kolgazi M, Sener G, Arbak S, Ercan F. 2022. Exercise improves testicular morphology and oxidative stress parameters in rats with testicular damage induced by a high-fat diet. Andrologia. 54:e14600. doi: 10.1111/and.14600.
  • Erdemir F, Atilgan D, Markoc F, Boztepe O, Suha-Parlaktas B, Sahin S. 2012. The effect of diet induced obesity on testicular tissue and serum oxidative stress parameters. Acta Urol Esp (English Edition). 36:153–159. doi: 10.1016/j.acuro.2011.06.019.
  • Fan Y, Liu Y, Xue K, Gu G, Fan W, Xu Y, Ding Z. 2015. Diet-induced obesity in male C57BL/6 mice decreases fertility as a consequence of disrupted blood-testis barrier. PLOS ONE. 10. doi:10.1371/journal.pone.0120775.
  • Farooq R, Lutfullah S, Ahmed M. 2014. Serum leptin levels in obese infertile men and women. Pak J Pharm Sci. 27:67–71.
  • Ferchichi H, Salouage I, Bacha S, Said DB, Gaies E, Boussaid M, Lakhal M, Klouz A. 2011 3. Effect of Myrtus communis L. extracts on attenuation of liver normothermic ischemia-reperfusion injury. J Transplant Technol Res. s3:2161–0991. doi: 10.4172/2161-0991.S3-001.
  • Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. 2004. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 114:1752–1761. doi:10.1172/JCI21625.
  • Ghanayem BI, Bai R, Kissling GE, Travlos G, Hoffler U. 2010. Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity. Biol Reprod. 82:96–104. doi:10.1095/biolreprod.109.078915.
  • Ghosh S, Mukherjee S. 2018. Testicular germ cell apoptosis and sperm defects in mice upon long-term high fat diet feeding. J Cell Physiol. 233:6896–6909. doi:10.1002/jcp.26581.
  • Hammoud AO, Gibson M, Peterson CM, Hamilton BD, Carrell DT. 2006. Obesity and male reproductive potential. J Androl. 27:619–626. doi:10.2164/jandrol.106.000125.
  • Hammoud AO, Meikle AW, Reis LO, Gibson M, Peterson CM, Carrell DT. 2012. Obesity and male infertility: a practical approach. Semin Reprod Med. 30:486–495. doi:10.1055/s-0032-1328877.
  • Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. 2008. Male obesity and alteration in sperm parameters. Fertil Steril. 90:2222–2225. doi:10.1016/j.fertnstert.2007.10.011.
  • Helbock HJ, Beckman KB, Ames BN. 1999. 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol. 300:156–166. doi:10.1016/S0076-6879(99)00123-8.
  • Hennia A, Miguel M, Nemmiche S. 2018. Antioxidant activity of Myrtus communis L. and Myrtus Nivellei Batt. & Trab. extracts: a brief review. Med (Basel). 5:89. doi: 10.3390/medicines5030089.
  • Herishanu Y, Rogowski O, Polliack A, Marilus R. 2006. Leukocytosis in obese individuals: possible link in patients with unexplained persistent neutrophilia. Eur J Haematol. 76:516–520. doi:10.1111/j.1600-0609.2006.00658.x.
  • Hersek İ, Köroğlu MK, Coşkunlu B, Ertaş B, Şener G, Ercan F. 2023. Apocynin ameliorates testicular toxicity in high-fat diet-fed rats by regulating oxidative stress. Clin Exp Health Sci. 13:75–83. doi: 10.33808/clinexphealthsci.1035133.
  • Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, Fabbri A. 1999. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab. 84:3673–3680. doi:10.1210/jcem.84.10.6082.
  • Jabri MA, Tounsi H, Rtibi K, Marzouki L, Sakly M, Sebai H. 2016. Ameliorative and antioxidant effects of myrtle berry seed (Myrtus communis) extract during reflux-induced esophagitis in rats. Pharm Biol. 54:1575–1585. doi:10.3109/13880209.2015.1107748.
  • Jia YF, Feng Q, Ge ZY, Guo Y, Zhou F, Zhang KS, Wang XW, Lu WH, Liang XW, Gu YQ. 2018. Obesity impairs male fertility through long-term effects on spermatogenesis. BMC Urol. 18:(1). doi: 10.1186/s12894-018-0360-5.
  • Johnsen SG. 1970. Testicular biopsy score count – a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones. 1:2–25. doi: 10.1159/000178170.
  • Jung RT. 1997. Obesity as a disease. British Med Bull. 53:307–321. doi: 10.1093/oxfordjournals.bmb.a011615.
  • Köroğlu KM, Çevik Ö, Şener G, Ercan F. 2019. Apocynin alleviates cisplatin-induced testicular cytotoxicity by regulating oxidative stress and apoptosis in rats. Andrologia. 51:e13227. doi: 10.1111/and.13227.
  • Leisegang K, Sengupta P, Agarwal A, Henkel R. 2021. Obesity and male infertility: mechanisms and management. Andrologia. 53:e13617. doi:10.1111/and.13617.
  • Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. 2005. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 20:208–215. doi: 10.1093/humrep/deh569.
  • Manna P, Jain SK. 2015. Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies. Metab Syndr Relat Disord. 13:423–444. doi: 10.1089/met.2015.0095.
  • Martini AC, Tissera A, Estofán D, Molina RI, Mangeaud A, Cuneo MFD, Ruiz RD. 2010. Overweight and seminal quality: a study of 794 patients. Fertil Steril. 94:1739–1743. doi: 10.1016/j.fertnstert.2009.11.017.
  • Mehra P, Garg M, Koul A, Bansal DD. 2013. Effect of (+) -catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male wistar rats. Indian J Exp Biol. 51:823–827. https://pubmed.ncbi.nlm.nih.gov/24266106/.
  • Miao XL, Gao GM, Jiang L, Xu R, Wan DP. 2018. Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis. Exp Ther Med. 15:2397–2403. doi: 10.3892/etm.2017.5672.
  • Mintziori G, Nigdelis MP, Mathew H, Mousiolis A, Goulis DG, Mantzoros CS. 2020. The effect of excess body fat on female and male reproduction. Metabolism. 107:154193. doi: 10.1016/j.metabol.2020.154193.
  • Moghimian M, Abtahi-Evari SH, Shokoohi M, Amiri M, Soltani M. 2017a. Effect of Syzygium aromaticum (clove) extract on seminiferous tubules and oxidative stress after testicular torsion in adult rats. Physiol Pharmacol. 21:343–350.
  • Moghimian M, Soltani M, Abtahi H, Shokoohi M. 2017b. Effect of vitamin C on tissue damage and oxidative stress following tunica vaginalis flap coverage after testicular torsion. J Pediatr Surg. 52:1651–1655. doi: 10.1016/j.jpedsurg.2017.07.001.
  • Mortazavi M, Salehi I, Alizadeh Z, Vahabian M, Roushandeh AM. 2014. Protective effects of antioxidants on sperm parameters and seminiferous tubules epithelium in high fat fed rats. J Reprod Infertil. 15:22–28.
  • Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. 2002. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord. 26:1459–1464. doi: 10.1038/sj.ijo.0802141.
  • Nagao T, Hase T, Tokimitsu I. 2007. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity. 15:1473–1483. doi: 10.1038/oby.2007.176.
  • Nallappan D, Ong KC, Palanisamy UD, Chua KH, Kuppusamy UR. 2020. Myricetin derivative-rich fraction from Syzygium malaccense prevents high-fat diet-induced obesity, glucose intolerance and oxidative stress in C57BL/6J mice. Arch Physiol Biochem. 129:186–197. doi: 10.1080/13813455.2020.1808019.
  • Ozbeyli D, Sen A, Kaya OTC, Ertas B, Aydemir S, Ozkan N, Yuksel M, Sener G. 2020. Myrtus communis leaf extract protects against cerulein-induced acute pancreatitis in rats. J Food Biochem. 44:e13130. doi: 10.1111/jfbc.13130.
  • Ozcan O, Ipekci H, Alev B, Ustundag UV, Ak E, Sen A, Alturfan EE, Sener G, Yarat A, Cetinel S, Akbay TT. 2019. Protective effect of Myrtle (Myrtus communis) on burn induced skin injury burns. Burns. 45:1856–1863. doi: 10.1016/j.burns.2019.07.015.
  • Palmer NO, Bakos HW, Owens JA, Setchell BP, Lane M. 2012. Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. Am J Physiol Endocrinol Metab. 302:E768–E780. doi: 10.1152/ajpendo.00401.2011.
  • Park HK, Ahima RS. 2015. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism. 64:24–34. doi: 10.1016/j.metabol.2014.08.004.
  • Patra S, Nithya S. 2015. Review of medicinal plants for anti-obesity activity. Transl Biomed. 6. doi: 10.21767/2172-0479.100021.
  • Qi J, Yang B, Ren C, Fu J, Zhang J. 2016. Swimming exercise alleviated insulin resistance by regulating tripartite motif family protein 72 expression and AKT signal pathway in sprague-dawley rats fed with high-fat diet. J Diabetes Res. 2016:1–9. doi: 10.1155/2016/1564386.
  • Ribas-Maynou J, Yeste M. 2020. Oxidative stress in male infertility: causes, effects in assisted reproductive techniques, and protective support of antioxidants. Biology. 9:77. MDPI AG. doi: 10.3390/biology9040077.
  • Romani A, Pinelli P, Mulinacci N, Vincieri FF, Tattini M. 1999. Identification and quantitation of polyphenols in leaves of Myrtus communis L. Chromatographia. 49:17–20. doi: 10.1007/BF02467181.
  • Sallmén M, Sandler DP, Hoppin JA, Blair A, Baird DD. 2006. Reduced fertility among overweight and obese men. Epidemiology. 17:520–523. doi: 10.1097/01.ede.0000229953.76862.e5.
  • Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. 2013. Obesity associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci. 14:10497–10538. doi: 10.3390/ijms140510497.
  • Sen A, Ozkan S, Recebova K, Cevik O, Ercan F, Demirci EK, Bitis L, Sener G. 2016. Effects of Myrtus communis extract treatment in bile duct ligated rats. J Surg Res. 205:359–367. doi: 10.1016/j.jss.2016.06.094.
  • Sen A, Yuksel M, Bulut G, Bitis L, Ercan F, Ozyilmaz-Yay N, Akbulut O, Cobanoğlu H, Ozkan S, Şener G. 2017. Therapeutic potential of Myrtus communis subsp. Communis extract against acetic acid-induced colonic inflammation in rats. J Food Biochem. 41:e12297. doi: 10.1111/jfbc.12297.
  • Shih CC, Lin CH, Lin WL. 2008. Effects of Momordica charantia on insülin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract. 81:134–143. doi: 10.1016/j.diabres.2008.04.023.
  • Shokoohi M, Khaki A, Shoorei H, Khaki AA, Moghimian M, Abtahi-Eivary SH. 2020. Hesperidin attenuated apoptotic-related genes in testicle of a male rat model of varicocele. Andrology. 8:249–258. doi: 10.1111/andr.12681.
  • Shokoohi M, Shoorei 1, Soltani M, Abtahi-Eivari SH, Salimnejad R, Moghimian M. 2018. Protective effects of the hydroalcoholic extract of Fumaria parviflora on testicular injury induced by torsion/detorsion in adult rats. Andrologia. 50:e13047. doi: 10.1111/and.13047.
  • Silva JF, Correa IC, Diniz TF, Lima PM, Santos RL, Cortes SF, Coimbra CC, Lemos VS. 2016. Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta. Front Physiol. 7:386. doi: 10.3389/fphys.2016.00386.
  • Suleiman JB, Nna VU, Zakaria Z, Othman ZA, Bakar ABA, Mohamed M. 2020. Obesity-induced testicular oxidative stress, inflammation and apoptosis: protective and therapeutic effects of orlistat. Rprod Toxicol. 95:113–122. doi: 10.1016/j.reprotox.2020.05.009.
  • Tas S, Tas B, Bassalat N, Jaradat N. 2018. In-vivo, hypoglycemic, hypolipidemic and oxidative stress inhibitory activities of Myrtus communis L. f ruits hydroalcoholic extract in normoglycemic and streptozotocin-induced diabetic rats. Biomed Res. 29:2727–2734. doi: 10.4066/biomedicalresearch.29-18-708.
  • Tuzlacı E. 2016. Türkiye’nin Geleneksel İlaç Bitkileri. İstanbul (In Turkish): İstanbul Tıp Kitabevi.
  • Unno K, Yamamoto H, Maeda KI, Takabayashi F, Yoshida H, Kikunaga N, Takamori N, Asahina S, Iguchi K, Sayama K, Hoshino M. 2009. Protection of brain and pancreas from high-fat diet: effects of catechin and caffeine. Physiol Behav. 96:262–269. doi: 10.1016/j.physbeh.2008.10.009.
  • Unusan N. 2020. Essential oils and microbiota: implications for diet and weight control. Trends Food Sci Technol. 104:60–71. doi: 10.1016/j.tifs.2020.07.014.
  • Vincent HK, Taylor AG. 2006. Biomarkers and potential mechanisms of obesity induced oxidant stress in humans. Int J Obes. 30:400–418. doi: 10.1038/sj.ijo.0803177.
  • Wang L, Wu H, Yang F, Dong W. 2019. The protective effects of myricetin against cardiovascular disease. J Nutr Sci Vitaminol (Tokyo). 65:470–476. doi: 10.3177/jnsv.65.470.
  • Wiersma JJ, Meuwese MC, JNIV M, Kastelein A, Tijssen JGP, Piek JJ, Trip MD. 2008. Diabetes mellitus type 2 is associated with higher levels of myeloperoxidase. Med Sc Monit. 14:406–410.
  • World Health Organization (WHO). 2020. Obesity and overweight. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
  • Xia SF, Le GW, Wang P, Qiu YY, Jiang YY, Tang X. 2016. Regressive effect of myricetin on hepatic steatosis in mice fed a high-fat diet. Nutrients. 8:799. doi: 10.3390/nu8120799.
  • Ye J, Luo D, Xu X, Sun M, Su X, Tian Z, Zhang M, Yu C, Guan Q. 2019. Metformin improves fertility in obese males by alleviating oxidative stress-induced blood-testis barrier damage. Oxid Med Cell Longev. 10:9151067. doi: 10.1155/2019/9151067.
  • Yi X, Gao H, Chen D, Tang D, Huang W, Li T, Ma T, Chang B. 2017. Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice. Am J Physiol Regul Integr Comp Physiol. 12:R501–10. doi: 10.1152/ajpregu.00405.2016.

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