In vivo evidence for the efflux transport of pentazocine from the brain across the blood–brain barrier using the brain efflux index method

References

• Asaba H, Hosoya K, Takanaga H, Ohtsuki S, Tamura E, Takizawa T, Terasaki T. 2000. Blood – brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. J Neurochem 75:1907–1916.
   PubMed Web of Science ®Google Scholar
• Bourasset F, Cisternino S, Temsamani J, Scherrmann JM. 2003. Evidence for an active transport of morphine-6-b-D-glucuronide but not P-glycoprotein-mediated at the blood – brain barrier. J Neurochem 86:1564–1567.
   PubMed Web of Science ®Google Scholar
• Callaghan R, Riordan JR. 1993. Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. J Biol Chem 268:16059–16064.
   PubMed Web of Science ®Google Scholar
• Cordon-Cardo C, O’Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. 1989. Multidrug- resistance gene (P-glycoprotein) is expressed by endothelial cells at blood – brain barrier sites. Proc Natl Acad Sci USA 86:695–698.
   PubMed Web of Science ®Google Scholar
• Crowe A. 2002. The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel. Eur J Pharmacol 440:7–16.
   PubMed Web of Science ®Google Scholar
• Dagenais C, Graff CL, Pollack GM. 2004. Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67:269–276.
   PubMed Web of Science ®Google Scholar
• Hosoya K, Sugawara M, Asaba H, Terasaki T. 1999. Blood – brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem 73:1206–1211.
   PubMed Web of Science ®Google Scholar
• Hosoya K, Asaba H, Terasaki T. 2000. Brain-to-blood efflux transport of estrone-3-sulfate at the blood – brain barrier in rats. Life Sci 67:2699–2711.
   PubMed Web of Science ®Google Scholar
• Kakee A, Terasaki T, Sugiyama Y. 1996. Brain efflux index as a novel method of analyzing efflux transport at the blood – brain barrier. J Pharmacol Exp Ther 277:1550–1559.
   PubMed Web of Science ®Google Scholar
• Kakee A, Takanaga H, Terasaki T, Naito M, Tsuruo T, Sugiyama Y. 2001. Efflux of a suppressive neurotransmitter, GABA, across the blood – brain barrier. J Neurochem 79:110–118.
   PubMed Web of Science ®Google Scholar
• Kawamura K, Kobayashi T, Matsuno K, Ishiwata K. 2003. Different brain kinetics of two sigma1 receptor ligands, [3H](+)- pentazocine and [11C]SA4503, by P-glycoprotein modulation. Synapse 48:80–86.
   PubMed Web of Science ®Google Scholar
• Kido Y, Tamai I, Ohnari A, Sai Y, Kagami T, Nezu J, Nikaido H, Hashimoto N, Asano M, Tsuji A. 2001. Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L -carnitine across the blood – brain barrier. J Neurochem 79:959–969.
   PubMed Web of Science ®Google Scholar
• Kikuchi R, Kusuhara H, Sugiyama D, Sugiyama Y. 2003. Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood – brain barrier. J Pharmacol Exp Ther 306:51–58.
   PubMed Web of Science ®Google Scholar
• Kusuhara H, Suzuki H, Terasaki T, Kakee A, Lemaire M, Sugiyama Y. 1997. P-glycoprotein mediates the efflux of quinidine across the blood – brain barrier. J Pharmacol Exp Ther 283:574–580.
   PubMed Web of Science ®Google Scholar
• Letrent SP, Polli JW, Humphreys JE, Pollack GM, Brouwer KR, Brouwer KL. 1999. P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells. Biochem Pharma- col 58:951–957.
   PubMed Web of Science ®Google Scholar
• Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T. 2003. Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab 23:432–440.
   PubMed Web of Science ®Google Scholar
• Moriki Y, Suzuki T, Fukami T, Hanano M, Tomono K, Watanabe J. 2004. Involvement of P-glycoprotein in blood – brain barrier transport of pentazocine in rats using brain uptake index method. Biol Pharm Bull 27:932–935.
   PubMed Web of Science ®Google Scholar
• Mroczkowska JE, Galla HJ, Nalecz MJ, Nalecz KA. 1997. Evidence for an asymmetrical uptake of L-carnitine in the blood – brain barrier in vitro. Biochem Biophys Res Commun 241:127–131.
   Google Scholar
• Ohnishi T, Tamai I, Sakanaka K, Sakata A, Yamashima T, Yamashita J, Tsuji A. 1995. In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxor- ubicin at the blood – brain barrier. Biochem Pharmacol 49:1541–1554.
   PubMed Web of Science ®Google Scholar
• Pardridge WM. 1999. Blood – brain barrier biology and method- ology. J Neurovirol 5:556–569.
   PubMed Web of Science ®Google Scholar
• Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Saheki A, Tsuji A. 1994. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood – brain barrier. Biochem Pharmacol 48:1989–1992.
   PubMed Web of Science ®Google Scholar
• Schinkel AH. 1999. P-glycoprotein, a gatekeeper in the blood – brain barrier. Adv Drug Deliv Rev 36:179–194.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Oshimi M, Tomono K, Hanano M, Watanabe J. 2002a. Investigation of transport mechanism of pentazocine across the blood – brain barrier using the in situ rat brain perfusion technique. J Pharm Sci 91:2346–2353.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Moriki Y, Goto H, Tomono K, Hanano M, Watanabe J. 2002b. Investigation on the influx transport mechanism of pentazocine at the blood – brain barrier in rats using the carotid injection technique. Biol Pharm Bull 25:1351–1355.
   PubMed Web of Science ®Google Scholar
• Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A. 1998. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378–20382.
   PubMed Web of Science ®Google Scholar
• Tamai I, China K, Sai Y, Kobayashi D, Nezu J, Kawahara E, Tsuji A. 2001. Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 1512:273–284.
   PubMed Web of Science ®Google Scholar
• Tsuji A, Tamai I. 1997. Blood – brain barrier function of P-glycoprotein. Adv Drug Deliv Rev 25:287–298.
   Web of Science ®Google Scholar
• Tsuji A, Terasaki T, Takabatake Y, Tenda Y, Tamai I, Yamashima T, Moritani S, Tsuruo T, Yamashita J. 1992. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci 51:1427–1437.
   PubMed Web of Science ®Google Scholar
• Tunblad K, Jonsson EN, Hammarlund-Udenaes M. 2003. Morphine blood – brain barrier transport is influenced by probenecid co-administration. Pharm Res 20:618–623.
   PubMed Web of Science ®Google Scholar
• Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V. 1999. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther 290:1482–1492.
   PubMed Web of Science ®Google Scholar
• Xie R, Hammarlund-Udenaes M, de Boer AG, de Lange EC. 1999. The role of P-glycoprotein in blood – brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (2 /2) and mdr1a (+ /+) mice. Br J Pharmacol 128:563–568.
   PubMed Web of Science ®Google Scholar
• Xie R, Bouw MR, Hammarlund-Udenaes M. 2000. Modelling of the blood – brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probene- cid-sensitive transport. Br J Pharmacol 131:1784–1792.
   PubMed Web of Science ®Google Scholar
• Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. 1981. A pharmacokinetic analysis program (MULTI) for microcom- puter. J Pharmacobiodyn 4:879–885.
   PubMedGoogle Scholar