The application of polysaccharide-based nanogels in peptides/proteins and anticancer drugs delivery

References

• Kabanov AV, Vinogradov SV. Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed Engl. 2009;48:5418–5429.
   PubMed Web of Science ®Google Scholar
• Soni KS, Desale SS, Bronich TK. Nanogels: an overview of properties, biomedical applications and obstacles to clinical translation. J Control Release. 2016;240:109–126.
   PubMed Web of Science ®Google Scholar
• Wang M, Zhao T, Liu Y, et al. Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy. Mater Sci Eng C Mater Biol Appl. 2017;71:1231–1240.
   PubMed Web of Science ®Google Scholar
• Mosafer J, Abnous K, Tafaghodi M, et al. In vitro and in vivo evaluation of anti-nucleolin-targeted magnetic PLGA nanoparticles loaded with doxorubicin as a theranostic agent for enhanced targeted cancer imaging and therapy. Eur J Pharm Biopharm. 2017;113:60–74.
   PubMed Web of Science ®Google Scholar
• Ge Y, Zhao Y, Li L. Preparation of sodium cholate-based micelles through non-covalent ibonding interaction and application as oral delivery systems for paclitaxel. Drug Deliv. 2016;23:2555–2565.
   PubMed Web of Science ®Google Scholar
• Srinivas NSK, Verma R, Kulyadi GP, et al. A quality by design approach on polymeric nanocarrier delivery of gefitinib: formulation, in vitro, and in vivo characterization. IJN. 2017;12:15–28.
   Web of Science ®Google Scholar
• Verma NK, Purohit MP, Equbal D, et al. Targeted smart pH and thermoresponsive N,O-carboxymethyl chitosan conjugated nanogels for enhanced therapeutic efficacy of doxorubicin in MCF-7 breast cancer cells. Bioconjugate Chem. 2016;27:2605–2619.
   PubMed Web of Science ®Google Scholar
• Su S, Wang H, Liu X, et al. iRGD-coupled responsive fluorescent nanogel for targeted drug delivery. Biomaterials. 2013;34:3523–3533.
   PubMed Web of Science ®Google Scholar
• Zhang L, Sang Y, Feng J, et al. Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery. J Drug Target. 2016;24:579–589.
   PubMed Web of Science ®Google Scholar
• Suarato G, Li W, Meng Y. Role of pH-responsiveness in the design of chitosan-based cancer nanotherapeutics: A review. Biointerphases. 2016;11:04B201.
   PubMed Web of Science ®Google Scholar
• Ahmed TA, Aljaeid BM. Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery. Drug Des Devel Ther. 2016;10:483–507.
   PubMed Web of Science ®Google Scholar
• Zhang X, Yang X, Ji J, et al. Tumor targeting strategies for chitosan-based nanoparticles. Colloids Surf B Biointerfaces. 2016;148:460–473.
   PubMed Web of Science ®Google Scholar
• Zubareva A, Ily'ina A, Prokhorov A, et al. Characterization of protein and peptide binding to nanogels formed by differently charged chitosan derivatives. Molecules. 2013;18:7848–7864.
   PubMed Web of Science ®Google Scholar
• Wang Y, Xu S, Xiong W, et al. Nanogels fabricated from bovine serum albumin and chitosan via self-assembly for delivery of anticancer drug. Colloids Surf B Biointerfaces. 2016;146:107–113.
   PubMed Web of Science ®Google Scholar
• Feng C, Li J, Kong M, et al. Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery. Colloids Surf B Biointerfaces. 2015;128:439–447.
   PubMed Web of Science ®Google Scholar
• Oh NM, Oh KT, Baik HJ, et al. A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: in vitro evaluation. Colloids Surf B Biointerfaces. 2010;78:120–126.
   PubMed Web of Science ®Google Scholar
• Naeye B, Deschout H, Roding M, et al. Hemocompatibility of siRNA loaded dextran nanogels. Biomaterials. 2011;32:9120–9127.
   PubMed Web of Science ®Google Scholar
• Nagahama K, Sano Y, Kumano T. Anticancer drug-based multifunctional nanogels through self-assembly of dextran-curcumin conjugates toward cancer theranostics. Bioorg Med Chem Lett. 2015;25:2519–2522.
   PubMed Web of Science ®Google Scholar
• Qader SAUL, Iqbal L, Aman A, et al. Production of dextran by newly isolated strains of leuconostoc mesenteroides PCSIR-4 and PCSIR-9. Turk J Biochem. 2005;31:21–26.
   Google Scholar
• Molinos M, Carvalho V, Silva DM, et al. Development of a hybrid dextrin hydrogel encapsulating dextrin nanogel as protein delivery system. Biomacromolecules. 2012;13:517–527.
   PubMed Web of Science ®Google Scholar
• Van Thienen TG, Raemdonck K, Demeester J, et al. Protein release from biodegradable dextran nanogels. Langmuir. 2007;23:9794–9801.
   PubMed Web of Science ®Google Scholar
• Manchun S, Cheewatanakornkool K, Dass CR, et al. Novel pH-responsive dextrin nanogels for doxorubicin delivery to cancer cells with reduced cytotoxicity to cardiomyocytes and stem cells. Carbohydr Polym. 2014;114:78–86.
   PubMed Web of Science ®Google Scholar
• Manchun S, Dass CR, Cheewatanakornkool K, et al. Enhanced anti-tumor effect of pH-responsive dextrin nanogels delivering doxorubicin on colorectal cancer. Carbohydr Polym. 2015;126:222–230.
   PubMed Web of Science ®Google Scholar
• d'Ayala GG, Malinconico M, Laurienzo P. Marine derived polysaccharides for biomedical applications: chemical modification approaches. Molecules. 2008;13:2069–2106.
   PubMed Web of Science ®Google Scholar
• Leonard M, De Boisseson MR, Hubert P, et al. Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties. J Control Release. 2004;98:395–405.
   PubMed Web of Science ®Google Scholar
• Vallee F, Muller C, Durand A, et al. Synthesis and rheological properties of hydrogels based on amphiphilic alginate-amide derivatives. Carbohydr Res. 2009;344:223–228.
   PubMed Web of Science ®Google Scholar
• Yoon DY, Kim JC. In vivo residence duration of human growth hormone loaded in nanogels comprising cinnamoyl alginate, cinnamoyl Pluronic F127 and cinnamoyl poly(ethylene glycol). Int J Pharm. 2016;509:229–236.
   PubMed Web of Science ®Google Scholar
• Li P, Luo Z, Liu P, et al. Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses. J Control Release. 2013;168:271–279.
   PubMed Web of Science ®Google Scholar
• Prestwich GD. Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine. J Control Release. 2011;155:193–199.
   PubMed Web of Science ®Google Scholar
• Silva JP, Goncalves C, Costa C, et al. Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment. J Control Release. 2016;235:112–124.
   PubMed Web of Science ®Google Scholar
• Wei X, Senanayake TH, Warren G, et al. Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Bioconjugate Chem. 2013;24:658–668.
   PubMed Web of Science ®Google Scholar
• Yao HJ, Zhang YG, Sun L, et al. The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells. Biomaterials. 2014;35:9208–9223.
   PubMed Web of Science ®Google Scholar
• Liang K, Ng S, Lee F, et al. Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels. Acta Biomater. 2016;33:142–152.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Wang X, Chen J, et al. Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors. J Control Release. 2016;244:229–239.
   PubMed Web of Science ®Google Scholar
• Yang C, Wang X, Yao X, et al. Hyaluronic acid nanogels with enzyme-sensitive cross-linking group for drug delivery. J Control Release. 2015;205:206–217.
   PubMed Web of Science ®Google Scholar
• Hirakura T, Yasugi K, Nemoto T, et al. Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: new system for sustained delivery of protein with a chaperone-like function. J Control Release. 2010;142:483–489.
   PubMed Web of Science ®Google Scholar
• Chou HS, Larsson M, Hsiao MH, et al. Injectable insulin-lysozyme-loaded nanogels with enzymatically-controlled degradation and release for basal insulin treatment: in vitro characterization and in vivo observation. J Control Release. 2016;224:33–42.
   PubMed Web of Science ®Google Scholar
• Shimoda A, Sawada S, Akiyoshi K. Cell specific peptide-conjugated polysaccharide nanogels for protein delivery. Macromol Biosci. 2011;11:882–888.
   PubMed Web of Science ®Google Scholar
• Muraoka D, Harada N, Hayashi T, et al. Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity. ACS Nano. 2014;8:9209–9218.
   PubMed Web of Science ®Google Scholar
• Ramineni SK, Cunningham LL, Jr., Dziubla TD, et al. Competing properties of mucoadhesive films designed for localized delivery of imiquimod. Biomater Sci. 2013;1:753–762.
   PubMed Web of Science ®Google Scholar
• Mitragotri S, Burke PA, Langer R. Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat Rev Drug Discov. 2014;13:655–672.
   PubMed Web of Science ®Google Scholar
• Kammona O, Kiparissides C. Recent advances in nanocarrier-based mucosal delivery of biomolecules. J Control Release. 2012;161:781–794.
   PubMed Web of Science ®Google Scholar
• Castro PM, Fonte P, Sousa F, et al. Oral films as breakthrough tools for oral delivery of proteins/peptides. J Control Release. 2015;211:63–73.
   PubMed Web of Science ®Google Scholar
• Bourganis V, Karamanidou T, Kammona O, et al. Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics. Eur J Pharm Biopharm. 2017;111:44–60.
   PubMed Web of Science ®Google Scholar
• Wang J, Xu M, Cheng X, et al. Positive/negative surface charge of chitosan based nanogels and its potential influence on oral insulin delivery. Carbohydr Polym. 2016;136:867–874.
   PubMed Web of Science ®Google Scholar
• Dahl R, Mygind N. Anatomy, physiology and function of the nasal cavities in health and disease. Adv Drug Deliv Rev. 1998;29:3–12.
   PubMed Web of Science ®Google Scholar
• Luppi B, Bigucci F, Cerchiara T, et al. Chitosan-based hydrogels for nasal drug delivery: from inserts to nanoparticles. Expert Opin Drug Deliv. 2010;7:811–828.
   PubMed Web of Science ®Google Scholar
• Wang W, Sreekumar PG, Valluripalli V, et al. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014;191:4–14.
   PubMed Web of Science ®Google Scholar
• Kong IG, Sato A, Yuki Y, et al. Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun. 2013;81:1625–1634.
   PubMed Web of Science ®Google Scholar
• Fukuyama Y, Yuki Y, Katakai Y, et al. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol. 2015;8:1144–1153.
   PubMed Web of Science ®Google Scholar
• Patton JS, Fishburn CS, Weers JG. The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc. 2004;1:338–344.
   PubMedGoogle Scholar
• Patton JS, Byron PR. Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov. 2007;6:67–74.
   PubMed Web of Science ®Google Scholar
• Lee J, Lee C, Kim TH, et al. Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system. J Control Release. 2012;161:728–734.
   PubMed Web of Science ®Google Scholar
• Zhang X, Liang X, Gu J, et al. Investigation and intervention of autophagy to guide cancer treatment with nanogels. Nanoscale. 2017;9:150–163.
   PubMed Web of Science ®Google Scholar
• Zhu X, Sun Y, Chen D, et al. Mastocarcinoma therapy synergistically promoted by lysosome dependent apoptosis specifically evoked by 5-Fu@nanogel system with passive targeting and pH activatable dual function. J Control Release. 2017;254:107–118.
   PubMed Web of Science ®Google Scholar
• Wu H, Jin H, Wang C, et al. Synergistic cisplatin/doxorubicin combination chemotherapy for multidrug-resistant cancer via polymeric nanogels targeting delivery. ACS Appl Mater Interfaces. 2017;9:9426–9436.
   PubMed Web of Science ®Google Scholar
• Sahu P, Kashaw SK, Jain S, et al. Assessment of penetration potential of pH responsive double walled biodegradable nanogels coated with eucalyptus oil for the controlled delivery of 5-fluorouracil: in vitro and ex vivo studies. J Control Release. 2017;253:122–136.
   PubMed Web of Science ®Google Scholar
• Soni G, Yadav KS. Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art. Saudi Pharm J. 2016;24:133–139.
   PubMed Web of Science ®Google Scholar
• Jia X, Han Y, Pei M, et al. Multi-functionalized hyaluronic acid nanogels crosslinked with carbon dots as dual receptor-mediated targeting tumor theranostics. Carbohydr Polym. 2016;152:391–397.
   PubMed Web of Science ®Google Scholar
• Sarika PR, Nirmala RJ. Curcumin loaded gum arabic aldehyde-gelatin nanogels for breast cancer therapy. Mater Sci Eng C Mater Biol Appl. 2016;65:331–337.
   PubMed Web of Science ®Google Scholar
• P RS, James NR, P R AK, Raj DK. Preparation, characterization and biological evaluation of curcumin loaded alginate aldehyde-gelatin nanogels. Mater Sci Eng C Mater Biol. 2016;68:251–257.
   PubMed Web of Science ®Google Scholar
• Qiu L, Li Z, Qiao M, et al. Self-assembled pH-responsive hyaluronic acid-g-poly((L)-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin. Acta Biomater. 2014;10:2024–2035.
   PubMed Web of Science ®Google Scholar
• Tang DL, Song F, Chen C, et al. A pH-responsive chitosan-b-poly(p-dioxanone) nanocarrier: formation and efficient antitumor drug delivery. Nanotechnology. 2013;24:145101.
   PubMed Web of Science ®Google Scholar
• Manchun S, Dass CR, Sriamornsak P. Targeted therapy for cancer using pH-responsive nanocarrier systems. Life Sci. 2012;90:381–387.
   PubMed Web of Science ®Google Scholar
• Arunraj TR, Rejinold NS, Kumar NA, et al. Bio-responsive chitin-poly(L-lactic acid) composite nanogels for liver cancer. Colloids Surf B Biointerfaces. 2014;113:394–402.
   PubMed Web of Science ®Google Scholar
• He L, Liang H, Lin L, et al. Green-step assembly of low density lipoprotein/sodium carboxymethyl cellulose nanogels for facile loading and pH-dependent release of doxorubicin. Colloids Surf B Biointerfaces. 2015;126:288–296.
   PubMed Web of Science ®Google Scholar
• Meng F, Hennink WE, Zhong Z. Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials. 2009;30:2180–2198.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhu L, Wang Y, et al. Ultrasensitive GSH-responsive ditelluride-containing poly(ether-urethane) nanoparticles for controlled drug release. ACS Appl Mater Interfaces. 2016;8:35106–35113.
   PubMed Web of Science ®Google Scholar
• Kumar A, Lale SV, Aji Alex MR, et al. Folic acid and trastuzumab conjugated redox responsive random multiblock copolymeric nanocarriers for breast cancer therapy: in-vitro and in-vivo studies. Colloids Surf B Biointerfaces. 2017;149:369–378.
   PubMed Web of Science ®Google Scholar
• Xiao D, Hu JJ, Zhu JY, et al. A redox-responsive mesoporous silica nanoparticle with a therapeutic peptide shell for tumor targeting synergistic therapy. Nanoscale. 2016;8:16702–16709.
   PubMed Web of Science ®Google Scholar
• Zhao C, Shao L, Lu J, et al. Triple redox responsive poly(ethylene glycol)-polycaprolactone polymeric nanocarriers for fine-controlled drug release. Macromol Biosci. 2017;17:1600295. doi: 10.1002/mabi.201600295
   Web of Science ®Google Scholar
• Yin S, Huai J, Chen X, et al. Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid. Acta Biomater. 2015;26:274–285.
   PubMed Web of Science ®Google Scholar
• Maciel D, Figueira P, Xiao S, et al. Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity. Biomacromolecules. 2013;14:3140–3146.
   PubMed Web of Science ®Google Scholar
• Cui H, Du X, Wang J, et al. Poly(N-isopropylacrylamide) hydrogel-based shape-adjustable polyimide films triggered by near-human-body temperature. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:4197–4200.
   PubMedGoogle Scholar
• Wang Y, Xu H, Wang J, et al. Development of a thermally responsive nanogel based on chitosan-poly(N-isopropylacrylamide-co-acrylamide) for paclitaxel delivery. J Pharm Sci. 2014;103:2012–2021.
   PubMed Web of Science ®Google Scholar
• Seo S, Lee CS, Jung YS, et al. Thermo-sensitivity and triggered drug release of polysaccharide nanogels derived from pullulan-g-poly (l-lactide) copolymers. Carbohydr Polym. 2012;87:1105–1111.
   Web of Science ®Google Scholar
• Jang H, Kim YK, Huh H, et al. Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy. ACS Nano. 2014;8:467–475.
   PubMed Web of Science ®Google Scholar
• Rodrigues HF, Mello FM, Branquinho LC, et al. Real-time infrared thermography detection of magnetic nanoparticle hyperthermia in a murine model under a non-uniform field configuration. Int J Hyperthermia. 2013;29:752–767.
   PubMed Web of Science ®Google Scholar
• Khatun Z, Nurunnabi M, Nafiujjaman M, et al. A hyaluronic acid nanogel for photo-chemo theranostics of lung cancer with simultaneous light-responsive controlled release of doxorubicin. Nanoscale. 2015;7:10680–10689.
   PubMed Web of Science ®Google Scholar
• Yang H, Wang Q, Huang S, et al. Smart pH/redox dual-responsive nanogels for on-demand intracellular anticancer drug release. ACS Appl Mater Interfaces. 2016;8:7729–7738.
   PubMed Web of Science ®Google Scholar
• Pradhan L, Srivastava R, Bahadur D. pH- and thermosensitive thin lipid layer coated mesoporous magnetic nanoassemblies as a dual drug delivery system towards thermochemotherapy of cancer. Acta Biomater. 2014;10:2976–2987.
   PubMed Web of Science ®Google Scholar
• Rahimian K, Wen YF, Oh JK. Redox-responsive cellulose-based thermoresponsive grafted copolymers and in-situ disulfide crosslinked nanogels. Polymer. 2015;72:387–394.
   Web of Science ®Google Scholar
• Wen Y, Oh JK. Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy. Colloids Surf B Biointerfaces. 2015;133:246–253.
   PubMed Web of Science ®Google Scholar
• Feng C, Sun G, Wang Z, et al. Transport mechanism of doxorubicin loaded chitosan based nanogels across intestinal epithelium. Eur J Pharm Biopharm. 2014;87:197–207.
   PubMed Web of Science ®Google Scholar
• Nagpal K, Singh SK, Mishra DN. Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull. 2010;58:1423–1430.
   PubMed Web of Science ®Google Scholar
• Jain A, Jain SK. In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors. Eur J Pharm Sci. 2008;35:404–416.
   PubMed Web of Science ®Google Scholar
• Kim S, Park KM, Ko JY, et al. Minimalism in fabrication of self-organized nanogels holding both anti-cancer drug and targeting moiety. Colloids Surf B Biointerfaces. 2008;63:55–63.
   PubMed Web of Science ®Google Scholar
• Yu CY, Wang YM, Li NM, et al. In vitro and in vivo evaluation of pectin-based nanoparticles for hepatocellular carcinoma drug chemotherapy. Mol Pharm. 2014;11:638–644.
   PubMed Web of Science ®Google Scholar
• Joung YK, Jang JY, Choi JH, et al. Heparin-conjugated pluronic nanogels as multi-drug nanocarriers for combination chemotherapy. Mol Pharm. 2013;10:685–693.
   PubMed Web of Science ®Google Scholar
• Wu W, Yao W, Wang X, et al. Bioreducible heparin-based nanogel drug delivery system. Biomaterials. 2015;39:260–268.
   PubMed Web of Science ®Google Scholar
• Xi J, Zhou L, Dai H. Drug-loaded chondroitin sulfate-based nanogels: preparation and characterization. Colloids Surf B Biointerfaces. 2012;100:107–115.
   PubMed Web of Science ®Google Scholar