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Review Article

Advanced polymers and recent advancements on gastroretentive drug delivery system; a comprehensive review

ORCID Icon, ORCID Icon, , , &
Received 25 Jan 2024, Accepted 18 Apr 2024, Published online: 29 Apr 2024

References

  • Katariya C, Roy A. Floating drug delivery system for analgesic – a review. Int J Pharm Sci Rev Res. 2017;43(2):1–4.
  • Nunes R, Sarmento B, das Neves J. Formulation and delivery of anti-HIV rectal microbicides: advances and challenges. J Control Release. 2014;194:278–294. doi:10.1016/j.jconrel.2014.09.013.
  • Desai U, Lee E-C, Chung K, et al. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci USA. 2007;104(28):11766–11771. doi:10.1073/pnas.0705041104.
  • Yun YH, Lee BK, Park K. Controlled drug delivery: historical perspective for the next generation. J Control Release. 2015;219:2–7. doi:10.1016/j.jconrel.2015.10.005.
  • Pawar HA, Dhavale R. Development and evaluation of gastroretentive floating tablets of an antidepressant drug by thermoplastic granulation technique. Beni-Suef Univ J Basic Appl Sci. 2014;3(2):122–132. doi:10.1016/j.bjbas.2014.05.005.
  • Singh DY, Prasad NK. Double liposomes mediated dual drug targeting for treatment of Helicobacter pylori infections. Pharmazie. 2011;66(5):368–373.
  • Vinchurkar K, Sainy J, Khan MA, et al. Features and facts of a gastroretentive drug delivery system-a review. Turk J Pharm Sci. 2022;19(4):476–487. doi:10.4274/tjps.galenos.2021.44959.
  • Shah HP, Prajapati ST, Patel C. Gastroretentive drug delivery systems: from conception to commercial success. J Crit Rev. 2017;4(2):10. doi:10.22159/jcr.2017v4i2.16717.
  • Mathur P, Saroha K, Syan N, et al. Floating drug delivery system: an innovative acceptable approach in gastroretentive drug delivery. Arch Apll Sci Res. 2010;2(2):257–270.
  • Khan R. Gastroretentive drug delivery system – a review. Int J Pharm Bio Sci. 2013;4(2):630–646.
  • Dixit N. Floating drug delivery system. J Curr Pharm Res. 2011;7(1):6–20.
  • Garg T, Kumar A, Rath G, et al. Gastroretentive drug delivery systems for therapeutic management of peptic ulcer. Crit Rev Ther Drug Carrier Syst. 2014;31(6):8–14.
  • Reddy BV, Navaneetha K, Deepthi PSA. Gastroretentive drug delivery system – a review. J Global Trends Pharm Sci. 2013;4(1):1018–1033.
  • Sangekar S, Vadino WA, Chaudry I, et al. Evaluation of the effect of food and specific gravity of tablets on gastric retention time. Int J Pharm. 1987;35(3):187–191. doi:10.1016/0378-5173(87)90129-3.
  • Arora S, Ali J, Ahuja A, et al. Floating drug delivery systems: a review. AAPS PharmSciTech. 2005;6(3):E372–E390. doi:10.1208/pt060347.
  • Badoni A, Ojha A, Gnanarajan G, et al. Review on gastro retentive drug delivery system. Pharma Innov. 2012;1(8, Part A):32.
  • Arya P, Pathak K. Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: optimization and pharmacokinetics. Int J Pharm. 2014;460(1-2):1–12. doi:10.1016/j.ijpharm.2013.10.045.
  • Jamil F, Kumar S, Sharma S, et al. Review on stomach specific drug delivery systems: development and evaluation. Int J Res Pharm Biomed Sci. 2011;2(4):14271433.
  • Bala R, Pawar P, Khanna S, et al. Orally dissolving strips: a new approach to oral drug delivery system. Int J Pharm Investig. 2013;3(2):67–76. doi:10.4103/2230-973X.114897.
  • Chen Y-C, Ho H-O, Lee T-Y, et al. Physical characterizations and sustained release profiling of gastroretentive drug delivery systems with improved floating and swelling capabilities. Int J Pharm. 2013;441(1-2):162–169. doi:10.1016/j.ijpharm.2012.12.002.
  • Goud M, Pandey V. Gastroretentive drug delivery system. Int J Pharm Biol Sci. 2016;6(3):158–165. doi:10.21276/ijpbs.2016.6.3.19.
  • Pant S, Badola A, Kothiyal P. A review on gastroretentive drug delivery system. IJPBR. 2016;4(2):01–10. doi:10.30750/ijpbr.4.2.1.
  • Nayak AK, Malakar J, Sen KK. Gastroretentive drug delivery technologies: current approaches and future potential. J Pharm Educ Res. 2010;1(2):1.
  • Nur AO, Zhang JS. Recent progress in sustained/controlled oral delivery of captopril: an overview. Int J Pharm. 2000;194(2):139–146. doi:10.1016/s0378-5173(99)00362-2.
  • Gadge G, Sabale V, Khade A. Current approaches on gastro retentive drug delivery system: an overview. Int J Pharm Res Technol. 2019;9(2):16–28.
  • Charoenying T, Chaksmithanont P, Panomsuk S, et al. Fabrication of a novel high-density three-dimensional (3D)-printed device for domperidone tablets. Thai Bull Pharm Sci. 2023;18(1):97–105.
  • Chen J, Blevins WE, Park H, et al. Gastric retention properties of superporous hydrogel composites. J Control Release. 2000;64(1-3):39–51. doi:10.1016/s0168-3659(99)00139-x.
  • Rathod HJ, Mehta DP, Yadav JS. A review on gastroretentive drug delivery systems. PharmaTutor. 2016;4(7):29–40.
  • Verma A, Dubey J, Hegde RR, et al. Helicobacter pylori: past, current and future treatment strategies with gastroretentive drug delivery systems. J Drug Target. 2016;24(10):897–915. doi:10.3109/1061186X.2016.1171326.
  • Gupta R, Tripathi P, Bhardwaj P, et al. Recent advances in gastro retentive drug delivery systems and its application on treatment of H. pylori infections. JAPLR. 2018;7(4):404–410. doi:10.15406/japlr.2018.07.00258.
  • Pawar VK, Kansal S, Garg G, et al. Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems. Drug Deliv. 2011;18(2):97–110. doi:10.3109/10717544.2010.520354.
  • More S, Gavali K, Doke O, et al. Gastroretentive drug delivery system. J Drug Delivery Ther. 2018;8(4):24–35. doi:10.22270/jddt.v8i4.1788.
  • Naik DA, Matonis S, Balakrishnan G, et al. Intestinal retentive systems–recent advances and emerging approaches. J Mater Chem B. 2024;12(1):64–78. doi:10.1039/d3tb01842c.
  • Zhou W, Yu X, Zhang Z, et al. Preparation and evaluation of luteolin-loaded PLA-based shape memory gastroretentive drug delivery systems. Int J Pharm. 2024;650:123670. doi:10.1016/j.ijpharm.2023.123670.
  • Chountoulesi M, Demetzos C, Vlachou M. Modified-release drug delivery systems with emphasis on oral dosage forms. In: From current to future trends in pharmaceutical technology. Elsevier; 2024. p. 329–343. doi:10.1016/B978-0-323-91111-5.00009-3.
  • Bardonnet PL, Faivre V, Pugh WJ, et al. Gastroretentive dosage forms: overview and special case of Helicobacter pylori. J Control Release. 2006;111(1-2):1–18. doi:10.1016/j.jconrel.2005.10.031.
  • Tripathi J, Thapa P, Maharjan R, et al. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019;11(4):193. doi:10.3390/pharmaceutics11040193.
  • Yoshida T, Shakushiro K, Sako K. Ion-responsive drug delivery systems. Curr Drug Targets. 2018;19(3):225–238. doi:10.2174/1389450117666160527142138.
  • Gaur PK, Mishra S, Bhardwaj S, et al. Ion exchange resins in gastroretentive drug delivery: characteristics, selection, formulation and applications. J Pharmaceut Sci Pharmacol. 2014;1(4):304–312. doi:10.1166/jpsp.2014.1037.
  • Umamaheshwari R, Jain S, Jain N. A new approach in gastroretentive drug delivery system using cholestyramine. Drug Deliv. 2003;10(3):151–160. doi:10.1080/713840399.
  • Bajpai SK, Bajpai M, Saxena S. Ion exchange resins in drug delivery. In: SenGupta AK, editor. Ion exchange and solvent extraction: A series of advances. Vol. 18. CRC Press; 2007.
  • Gupta S, Benien P, Sahoo P. Ion exchange resins transforming drug delivery systems. CDD. 2010;7(3):252–262. doi:10.2174/156720110791560955.
  • Upadhye AA, Ambike AA, Mahadik KR, et al. Application of ion exchange resin in floating drug delivery system. Drug Dev Ind Pharm. 2008;34(10):1117–1124. doi:10.1080/03639040801973982.
  • Nakagawa T, Kondo S-I, Sasai Y, et al. Preparation of floating drug delivery system by plasma technique. Chem Pharm Bull (Tokyo). 2006;54(4):514–518. doi:10.1248/cpb.54.514.
  • Schneider F, Koziolek M, Weitschies W. In vitro and in vivo test methods for the evaluation of gastroretentive dosage forms. Pharmaceutics. 2019;11(8):416. doi:10.3390/pharmaceutics11080416.
  • Awasthi R, Kulkarni GT. Development of novel gastroretentive drug delivery system of gliclazide: hollow beads. Drug Dev Ind Pharm. 2014;40(3):398–408. doi:10.3109/03639045.2013.763817.
  • Deshpande AA, Shah NH, Rhodes CT, et al. Development of a novel controlled-release system for gastric retention. Pharm Res. 1997;14(6):815–819. doi:10.1023/a:1012171010492.
  • Klausner EA, Eyal S, Lavy E, et al. Novel levodopa gastroretentive dosage form: in-vivo evaluation in dogs. J Control Release. 2003;88(1):117–126. doi:10.1016/s0168-3659(02)00487-x.
  • Choi BY, Park HJ, Hwang SJ, et al. Preparation of alginate beads for floating drug delivery system: effects of CO2 gas-forming agents. Int J Pharm. 2002;239(1-2):81–91. doi:10.1016/s0378-5173(02)00054-6.
  • Rani S, Hari V, Reddy B, et al. The recent developments on gastric floating drug delivery systems: an overveiw. Int J Pharm Tech Res. 2010;2(1):524–534.
  • Ozdemir N, Ordu S, Ozkan Y. Studies of floating dosage forms of furosemide: in vitro and in vivo evaluations of bilayer tablet formulations. Drug Dev Ind Pharm. 2000;26(8):857–866. doi:10.1081/ddc-100101309.
  • Li S, Lin S, Chien YW, et al. Statistical optimization of gastric floating system for oral controlled delivery of calcium. AAPS PharmSciTech. 2001;2(1):E1–E22. doi:10.1208/pt020101.
  • Manwar JV, Panchale WA, Bakal RL, et al. Newer RP-HPLC method development and validation of cefixime and linezolide in bulk drugs and combined dosage form. Int J Pharm Life Sci. 2021;12(1):54–68.
  • Wu W, Zhou Q, Zhang HB, et al. Studies on nimodipine sustained-release tablet capable of floating on gastric fluid with prolonged gastric resident time. Yao Xue Xue Bao. 1997;32(10):786–790.
  • Dorożyński P, Kulinowski P, Jachowicz R, et al. Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: a technical note. AAPS PharmSciTech. 2007;8(1):E109–E112. doi:10.1208/pt0801015.
  • Singh B, Sharma V, Dhiman A, et al. Design of aloe vera-alginate gastroretentive drug delivery system to improve the pharmacotherapy. Polym-Plast Technol Eng. 2012;51(13):1303–1314. doi:10.1080/03602559.2012.698684.
  • Singh B, Sharma V, Chauhan D. Gastroretentive floating sterculia–alginate beads for use in antiulcer drug delivery. Chem Eng Res Des. 2010;88(8):997–1012. doi:10.1016/j.cherd.2010.01.017.
  • Md S, Ahuja A, Khar RK, et al. Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive ­microspheres: formulation and evaluation. Drug Delivery. 2011;18(4):255–264. doi:10.3109/10717544.2010.536270.
  • Batista PSP, de Morais AMMB, Pintado MME, et al. Alginate: pharmaceutical and medical applications. In: Cohen E, Merzendorfer H. editors. Extracellular sugar-based biopolymers matrices. Springer, Cham; 2019. p. 649–691. doi:10.1007/978-3-030-12919-4_16.
  • Varshi R, Jain V, Pal P. A review on advanced approaches and polymers used in gastroretentive drug delivery systems. J Drug Delivery Ther. 2022;12(4):181–185. doi:10.22270/jddt.v12i4.5422.
  • Malik R, Garg T, Goyal AK, et al. Polymeric nanofibers: targeted gastro-retentive drug delivery systems. J Drug Target. 2015;23(2):109–124. doi:10.3109/1061186X.2014.965715.
  • Waqar MA, Zaman M, Hameed H, et al. Formulation, characterization, and evaluation of β-Cyclodextrin functionalized hypericin loaded nanocarriers. ACS Omega. 2023;8(41):38191–38203. doi:10.1021/acsomega.3c04444.
  • Ashfaq A, Riaz T, Waqar MA, et al. A comprehensive review on transdermal patches as an efficient approach for the delivery of drug. Polym-Plast Technol Mater. 2024;63(8):1045–1069. doi:10.1080/25740881.2024.2317408.
  • Iqbal S, Waqar MA, Qureshi A, et al. A comprehensive review of the self-emulsifying drug delivery system (SEDDS) and its recently developed formulations. IJPIHS. 2023;5(1):45–58. doi:10.56536/ijpihs.v5i1.119.
  • Yassin AEB, Alsarra IA, Al-Mohizea AM. Chitosan beads as a new gastroretentive system of verapamil. Sci Pharm. 2006;74(4):175–188. doi:10.3797/scipharm.2006.74.175.
  • Säkkinen M, Tuononen T, Jürjenson H, et al. Evaluation of microcrystalline chitosans for gastro-retentive drug delivery. Eur J Pharm Sci. 2003;19(5):345–353. doi:10.1016/s0928-0987(03)00121-0.
  • Gupta NV, Shivakumar H. Development of a gastroretentive drug delivery system based on superporous hydrogel. Trop J Pharm Res. 2010;9(3):12–24. doi:10.4314/tjpr.v9i3.56286.
  • Murphy CS, Pillay V, Choonara YE, et al. Gastroretentive drug delivery systems: current developments in novel system design and evaluation. Curr Drug Deliv. 2009;6(5):451–460. doi:10.2174/156720109789941687.
  • Gudigennavar A. Development and evaluation of gastro-retentive drug delivery systems of cefuroxime axetil. Afr J Pharm Pharmacol. 2013;7(20):1332–1338. doi:10.5897/AJPP12.1211.
  • Weon KY, Kim SG. Design of swelling gastroretentive drug delivery system for sustained release of metformin. J Korea Acad-Indus Cooper Soc. 2020;21(3):215–222.
  • Selvakumaran S, Muhamad II. Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of cross linker. Int J Pharm. 2015;496(2):323–331. doi:10.1016/j.ijpharm.2015.10.005.
  • Gunda RK, Vijayalakshmi A. Formulation development and evaluation of gastro retentive drug delivery systems – a review. J Pharm Res. 2017;8(1):11–20.
  • Selvakumaran S, Muhamad II, Abd Razak SI. Evaluation of kappa carrageenan as potential carrier for floating drug delivery system: effect of pore forming agents. Carbohydr Polym. 2016;135:207–214. doi:10.1016/j.carbpol.2015.08.051.
  • Sriamornsak P. Application of pectin in oral drug delivery. Expert Opin Drug Deliv. 2011;8(8):1009–1023. doi:10.1517/17425247.2011.584867.
  • Pund AU, Shendge RS, Pote AK. Current approaches on gastroretentive drug delivery systems. J Drug Delivery Ther. 2020;10(1):139–146. doi:10.22270/jddt.v10i1.3803.
  • Talukder R, Fassihi R. Gastroretentive delivery systems: hollow beads. Drug Dev Ind Pharm. 2004;30(4):405–412. doi:10.1081/ddc-120030935.
  • Prakash Rao B, Kottam NA, Snehith VS, et al. Development of gastro retentive drug delivery system of cephalexin by using factorial design. Ars Pharm. 50(1):8–23.
  • Jagdale SC, Agavekar AJ, Pandya SV, et al. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech. 2009;10(3):1071–1079. doi:10.1208/s12249-009-9300-8.
  • Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. AAPS PharmSciTech. 2004;5(2):e34–e82. doi:10.1208/pt050234.
  • Moghni N, Hadjsadok A. Design and characterization of alginate-xanthan based raft forming suspension for acid reflux treatment: rheological study and produced CO2 assessment. J Drug Delivery Sci Technol. 2024;91:105198. doi:10.1016/j.jddst.2023.105198.
  • Blynskaya EV, Tishkov SV, Vinogradov VP, et al. Polymeric excipients in the technology of floating drug delivery systems. Pharmaceutics. 2022;14(12):2779. doi:10.3390/pharmaceutics14122779.
  • Patole R, Chaware B, Mohite V, et al. A review for gastro-retentive drug delivery system. Asian J Pharm Res Dev. 2023;11(4):79–94. doi:10.22270/ajprd.v11i4.1291.
  • Singh J, Fateh MV. Prospectives of natural polymers in gastroretentive floating drug delivery system: a review. EPRA Int J Res Dev. 2023;8(1):157–164.
  • Shripad Thorat Y, Pralhad Bagewadikar P, Mali G, et al. In situ gelling gastro-retentive raft containing ficus racemosa fruit extract: a promising approach to treat GERD. RJPT. 2023;16(8):3951–3956. doi:10.52711/0974-360X.2023.00650.
  • Juweriya A, Ratnamala K. Formulation and evaluation of sintered gastroretentive tablets of vildagliptin using design of experiment. Asian J Pharm Clin Res. 2023;16(6):46–52. doi:10.22159/ajpcr.2023.v16i6.47150.
  • Ughade S, Bawankar R, Mundhada D. Nifedipine gastro retentive drug delivery system: formulation, characterization and evaluation. IJPS. 2023;85(3):4–12. doi:10.36468/pharmaceutical-sciences.1133.
  • Zhang W-Q, Chen L-B, Zhe AN, et al. Gastroretentive floating microspheres of carvedilol: preparation, in vitro and in vivo characterization. J Biomater Tissue Eng. 2016;6(1):74–78. doi:10.1166/jbt.2016.1413.
  • Kim J-Y, Kim S-h, Rhee Y-S, et al. Preparation of hydroxypropylmethyl cellulose-based porous matrix for gastroretentive delivery of gabapentin using the freeze-drying method. Cellulose. 2013;20(6):3143–3154. doi:10.1007/s10570-013-0048-7.
  • Alkhalidi BA, Albarahmieh E, Qassim SMA, et al. An investigation into formulation and processing strategies to drive gastroretention of gabapentin tablets. J Pharm Innov. 2017;12(4):367–373. doi:10.1007/s12247-017-9300-2.
  • Mandal S, Km Bhumika B, Kumar M, et al. A novel approach on micro sponges drug delivery system: method of preparations, application, and its future prospective. Ind J Pharm Edu Res. 2024;58(1):45–63. doi:10.5530/ijper.58.1.5.
  • Mishra Y, Mishra V, Aljabali AAA, et al. 3D printed personalized Colon-targeted tablets: a novel approach in ulcerative colitis management. Curr Drug Deliv. 2024;8(2):15–25. doi:10.2174/1567201821666230915150544.
  • Shinde AJ. Formulation and optimization of expandable gastroretentive tablet of diltiazem hydrochloride using factorial design. Asian J Pharm. 2017;11(01):54–68.
  • Shinde AJ, Misale GM, Salokhe SV. Development and evaluation of bilayer mucoahesive gastroretentive tablet of diltiazem hydrochloride. Int J Pharm Pharm Sci. 2014;6:365–370.
  • Patil K, Patil J, Bharade S, et al. Design and development of sodium alginate/carboxymethyl cellulose in situ gelling system for gastroretentive delivery of lisinopril. jrp. 2023;27(2)(27(2):825–836. doi:10.29228/jrp.363.
  • Thummala UK, Vallabhareddy PS, Sarella PNK. Enhancing oral absorption of orlistat through gastroretentive mucoadhesive pellets: formulation and evaluation. J Cli Pharm Res. 2023;8(5):9–17. doi:10.61427/jcpr.v3.i2.2023.88.
  • Li M. Development of gastroretentive floating pellets using hot melt extrusion. Eur J Pharm Sci. 2023;5(9):8–15.
  • Dhiman S, Philip N, Gurjeet Singh T, et al. An insight on novel approaches & perspectives for gastro-retentive drug delivery systems. Curr Drug Deliv. 2023;20(6):708–729. doi:10.2174/1567201819666220819200236.
  • Giri TK, Verma S, Badwaik H, et al. Prospective and new findings of hydroxypropyl methylcellulose (HPMC) as a potential carrier for gastrorententive drug delivery systems. DDL. 2012;2(2):98–107. doi:10.2174/2210304x11202020098.
  • Reddy Dumpa N, Bandari S, Repka MA. Novel gastroretentive floating pulsatile drug delivery system produced via hot-melt extrusion and fused deposition modeling 3D printing. Pharmaceutics. 2020;12(1):52. doi:10.3390/pharmaceutics12010052.
  • Vo AQ, Feng X, Pimparade M, et al. Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion. Eur J Pharm Sci. 2017;102:71–84. doi:10.1016/j.ejps.2017.02.040.
  • Khizer Z, Akram MR, Tahir MA, et al. Personalised 3D-printed mucoadhesive gastroretentive hydrophilic matrices for managing overactive bladder (OAB). Pharmaceuticals. 2023;16(3):372. doi:10.3390/ph16030372.
  • Uboldi M, Chiappa A, Rossi M, et al. Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin. Expert Opin Drug Deliv. 2024;21(1):131–149. doi:10.1080/17425247.2023.2294884.
  • Liang Y-K, Cheng W-T, Chen L-C, et al. Development of a swellable and floating gastroretentive drug delivery system (sf GRDDS) of ciprofloxacin hydrochloride. Pharmaceutics. 2023;15(5):1428. doi:10.3390/pharmaceutics15051428.
  • Jagdale S, Agarwal B, Dixit A, et al. Chitosan as excellent bio-macromolecule with myriad of anti-activities in biomedical applications – a review. Int J Biol Macromol. 2023;257(Pt 2):128697. doi:10.1016/j.ijbiomac.2023.128697.
  • Arora D, Khurana B. Computer-aided biopharmaceutical characterization: gastrointestinal absorption simulation and in silico computational modeling. In: Saharan VA, editor. Computer aided pharmaceutics and drug delivery: an application guide for students and researchers of pharmaceutical sciences. Singapore: Springer Nature Singapore; 2022. p. 189–215. doi:10.1007/978-981-16-5180-9_7.
  • Sen O, Manna S, Nandi G, et al. Recent advances in alginate based gastroretentive technologies for drug delivery applications. Med Novel Technol Dev. 2023;18:100236. doi:10.1016/j.medntd.2023.100236.
  • Aleksandrov M, Gelevska O, Stojova C, et al. Cannabidiol based borderline products – from development to registration processes. Maced Pharm Bull. 2023;69(03):149–150. doi:10.33320/maced.pharm.bull.2023.69.03.073073.
  • De Smedt SC, Braeckmans K, Remaut K, et al. Exploring light for advanced drug delivery & surgery in the eye. Nano Today. 2020;31:100837.
  • Hamdi DS, Mohamed MBM. Formulation of metoclopramide HCl gastroretentive film and in vitro-in silico prediction using Gastroplus® PBPK software. Saudi Pharm J. 2022;30(12):1816–1824.
  • Patel K, Patidar D, Sharma N. An recent advantage on gastroretentive drug delivery system: an overview. J Pharm Negative Res. 2022;5(10):4521–4529.
  • Gayakwad BP, Bavaskar SR, Fulzele S, et al. Natural polymers in the development of gastroretentive systems: a review. Nat Volatiles Essent Oils. 2021;15(5):2895–2906.
  • Sadhu PK, Baji AA, Shah NV, et al. An approaches and patents on controlled release gastroretentive drug delivery system – a review. Int J Pharm Res. 2020;12(2):5–14.
  • Samala ML, Janga RB. Design, statistical optimization of Nizatidine floating tablets using natural polymer. Fut J Pharm Sci. 2021;7(1):1–24. doi:10.1186/s43094-020-00140-z.
  • Mangla B, Jain A, Malik DS. Corn fiber gum as a potential platform for the preparation of bioadhesive floating tablets of domperidone. Int J Pharm Res. 2021;13(1):25–35.
  • Kowsalya R. Formulation and optimization of floating drug delivery system oflevofloxacin hemihydrate. Namakkal (India): PGP College of Pharmaceutical Science and Research Institute; 2017.
  • Başarir NS, Mesut B, Özsoy Y. A review on current perspective of gastroretentive drug delivery systems prioritising floating dosage forms. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2021;4(2):43–64.
  • Ahmed W, El-Gogary RI, Nasr M, et al. Development and in vitro/in vivo evaluation of itopride hydrochloride expanding tablets. J Pharm Innov. 2023;18(3):1350–1361. doi:10.1007/s12247-023-09729-2.
  • Wiwattanapatapee R, Klabklay K, Raksajit N, et al. The development of an in-situ biopolymer-based floating gel for the oral delivery of metformin hydrochloride. Heliyon. 2023;9(4):e14796. doi:10.1016/j.heliyon.2023.e14796.
  • Srivastava AK, Rajput DS, Gupta N, et al. Formulation and evaluation of nicorandil floating tablets using natural polymers. Asian J Pharm Res Dev. 2023;11(2):74–82. doi:10.22270/ajprd.v11i2.1250.
  • George A, Shrivastav PS. Plant polysaccharides as excipients in oral drug delivery. In: Nayak AK, Hasnain MS, Pal D, editors. Plant polysaccharides as pharmaceutical excipients. Elsevier; 2023. p. 215–247. doi:10.1016/B978-0-323-90780-4.00021-8.
  • Kwang GD, Sampathkumar K, Loo SCJ. Ultralong floating hydrogel raft for prolonged gastric retention. MRS Bull. 2023;48(4):342–350. doi:10.1557/s43577-022-00406-2.
  • Bharati S, Gaikwad V, Pawar A, et al. Investigation of a biopolymer-based pH-responsive and sustained release raft-gel-forming tablet of famotidine: in-vitro, ex-vivo, bioavailability and anti-ulcer evaluation in New Zealand albino rabbit. J Drug Delivery Sci Technol. 2023;86:104649. doi:10.1016/j.jddst.2023.104649.
  • Anothra P, Pradhan D, Halder J, et al. Gastroretentive drug delivery system in cancer chemotherapy. Curr Drug Deliv. 2023;20(5):483–496. doi:10.2174/1567201819666220608141124.
  • Chourasiya R, Lanjhiyana SK, Jaiswal M, et al. Overview on gastro retentive drug delivery systems: current scenario and future prospective. Int J Pharm. 2016;5(4):144–158.
  • Ghosh N, Rhithuparna D, Khatoon R, et al. Sulphonic-acid functionalized novel Limonia acidissima carbonaceous catalyst for biodiesel synthesis from Millettia pinnata oil: optimization, kinetics, thermodynamics and cost analysis. J Cleaner Prod. 2023;394:136362. doi:10.1016/j.jclepro.2023.136362.
  • Yusnaini R, Ikhsan, Iskandar, et al. The identification of phytocompounds from Limonia acidissima L. fruit: a short report and updated review–focusing on antihyperuricemic and antiarthritic activities. Int J PHE. 2023;3(1):418–423. doi:10.55299/ijphe.v3i1.716.
  • Zaya KS, Nayak MJ, Mishra JN. Formulation and evaluation of floating tablet of atenolol for the treatment of hypertension. J Popul Therapeut Clin Pharmacol. 2023;30(4):765–776.
  • Mahajan N, Kharwade R, Badole P. Development of pharmaceutical aids from agricultural and other wastes. In: Raut NA, Kokare DM, Bhanvase BA, Randive KR, Dhoble SJ, editors. 360-degree waste management. Vol. 1. Elsevier; 2023. p. 67–87. doi:10.1016/B978-0-323-90760-6.00006-0.
  • Guru PR, Kar RK, Nayak AK, et al. A comprehensive review on pharmaceutical uses of plant-derived biopolysaccharides. Int J Biol Macromol. 2023;233:123454. doi:10.1016/j.ijbiomac.2023.123454.
  • Biswas GR, Bhattacharya S, Majee SB. Effect of gum karaya on release pattern of amoxycillin trihydrate from encapsulated matrix-based formulations. RJPT. 2023;16(2):721–726. doi:10.52711/0974-360X.2023.00123.
  • Mahmoud ZH. Formulation and sustained-release of verapamil hydrochloride tablets. Chemist. 2023;5(1):76.
  • Ainurofiq A, et al. Chitosan as floating-mucoadhesive polymers in gastroretentive drug delivery. Sci Eng Health Stud. 2023;1(9):23050027.
  • Herdiana Y, Husni P, Nurhasanah S, et al. Chitosan-based nano systems for natural antioxidants in breast cancer therapy. Polymers (Basel). 2023;15(13):2953. doi:10.3390/polym15132953.
  • Jalodiya K, Jain S, Shukla K. Formulation and evaluation of gastro-retentive floating tablets of terbinafine. GSC Biol Pharm Sci. 2020;13(1):257–266.
  • Lin H-L, Chen L-C, Cheng W-T, et al. Preparation and characterization of a novel swellable and floating gastroretentive drug delivery system (sf GRDDS) for enhanced oral bioavailability of nilotinib. Pharmaceutics. 2020;12(2):137. doi:10.3390/pharmaceutics12020137.
  • Desu PK, Pasam V, Kotra V. Formulation and in vitro evaluation of superporous hydrogel based gastroretentive drug delivery system of vildagliptin. jrp. 2019;23(5):873–885. doi:10.35333/jrp.2019.35.
  • Karemore MN, Avari JG. Formulation, optimization, and in vivo evaluation of gastroretentive drug delivery system of nifedipine for the treatment of preeclampsia. AAPS PharmSciTech. 2019;20(5):200. doi:10.1208/s12249-019-1391-2.
  • Kiran CVR, Gopinath C. Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS). Mater Today: Proc. 2021;46:3056–3061. doi:10.1016/j.matpr.2021.02.381.
  • Namdev A, Jain D. Floating drug delivery systems: an emerging trend for the treatment of peptic ulcer. Curr Drug Deliv. 2019;16(10):874–886. doi:10.2174/1567201816666191018163519.
  • Klausner EA, Lavy E, Friedman M, et al. Expandable gastroretentive dosage forms. J Control Release. 2003;90(2):143–162. doi:10.1016/s0168-3659(03)00203-7.
  • El-Zahaby SA, Kassem AA, El-Kamel AH. Formulation and in vitro evaluation of size expanding gastro-retentive systems of levofloxacin hemihydrate. Int J Pharm. 2014;464(1-2):10–18. doi:10.1016/j.ijpharm.2014.01.024.
  • Mehta M, Pandey P, Mahajan S, et al., Gastro retentive drug delivery systems: an overview. Res J Pharm Technol. 2018;11(5):2157–2160. doi:10.5958/0974-360X.2018.00398.0.
  • Mandal UK, Chatterjee B, Senjoti FG. Gastro-retentive drug delivery systems and their in vivo success: a recent update. Asian J Pharm Sci. 2016;11(5):575–584. doi:10.1016/j.ajps.2016.04.007.
  • Sivaneswari S, Karthikeyan E, Chandana P. Novel expandable gastro retentive system by unfolding mechanism of levetiracetam using simple lattice design–formulation optimization and in vitro evaluation. Bull Fac Pharm Cairo Univ. 2017;55(1):63–72. doi:10.1016/j.bfopcu.2017.02.003.
  • Rimawi IB, Muqedi RH, Kanaze FI. Development of gabapentin expandable gastroretentive controlled drug delivery system. Sci Rep. 2019;9(1):11675. doi:10.1038/s41598-019-48260-8.
  • Dey S, Chattopadhyay S, Mazumder B. Formulation and evaluation of fixed-dose combination of bilayer gastroretentive matrix tablet containing atorvastatin as fast-release and atenolol as sustained-release. Biomed Res Int. 2014;2014:396106–396112. doi:10.1155/2014/396106.
  • Zhao S, Lv Y, Zhang B, et al. Gastroretentive drug delivery systems for the treatment of Helicobacter pylori. World J Gastroenterol. 2014;20(28):9321.
  • Traverso G, Langer R. Perspective: special delivery for the gut. Nature. 2015;519(7544):S19. doi:10.1038/519S19a.
  • Souza MPCd, Sábio RM, Ribeiro TdC, et al. Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems. Int J Biol Macromol. 2020;159:804–822. doi:10.1016/j.ijbiomac.2020.05.104.
  • Vrettos N-N, Roberts CJ, Zhu Z. Gastroretentive technologies in tandem with controlled-release strategies: a potent answer to oral drug bioavailability and patient compliance implications. Pharmaceutics. 2021;13(10):1591. doi:10.3390/pharmaceutics13101591.
  • Zaman M, Akhtar F, Baseer A, et al. Formulation development and in-vitro evaluation of gastroretentive drug delivery system of loxoprofen sodium: a natural excipients based approach. Pakistan J Pharm Sci. 2021;34(1):057–063.
  • Sapavatu SN, Jadi RK. Formulation development and characterization of gastroretentive drug delivery systems of loratadine. Int J App Pharm. 2019;11:91–99. doi:10.22159/ijap.2019v11i6.35194.
  • Kumar VV, Gladiola BD, Chetty CM, et al. Formulation and evaluation of gastro retentive drug delivery system of zanamivir using different polymers. JBPR. 2019;8(4):41–47. doi:10.32553/jbpr.v8i4.641.
  • Alaithan S, Naveen NR, Goudanavar PS, et al. Development of novel unfolding film system of Itopride hydrochloride using box-Behnken design – a gastro retentive approach. Pharmaceuticals. 2022;15(8):981. doi:10.3390/ph15080981.
  • Melocchi A, Uboldi M, Inverardi N, et al. Expandable drug delivery system for gastric retention based on shape memory polymers: development via 4D printing and extrusion. Int J Pharm. 2019;571:118700. doi:10.1016/j.ijpharm.2019.118700.
  • Sharma D, Sharma D. Novel swellable/expandable gastroretentive floating films of gliclazide folded in capsule shell for the effective management of diabetes mellitus: formulation development, optimization and in vitro evaluation. CDTH. 2021;16(1):100–112. doi:10.2174/1574885515999201201122710.
  • Ha J-M, Seo J-W, Kim S-H, et al. Implementation of quality by design for formulation of rebamipide gastro-retentive tablet. AAPS PharmSciTech. 2017;18(8):3129–3139. doi:10.1208/s12249-017-0797-y.
  • Parikh DC, Amin AF. In vitro and in vivo techniques to assess the performance of gastro-retentive drug delivery systems: a review. Expert Opin Drug Deliv. 2008;5(9):951–965. doi:10.1517/17425247.5.9.951.

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