46
Views
13
CrossRef citations to date
0
Altmetric
Regular Paper

Structure-Toxicity Analyses of Tetrahymena Pyriformis Exposed to Pyridines - An Examination Into Extension of Surface-Response Domains

, &
Pages 489-512 | Received 04 May 2000, Accepted 22 Jul 2000, Published online: 24 Sep 2006

References

  • Bradbury , S. P. 1994 . Predicting modes of toxic action from chemical structure: An overview . SAR QSAR Environ. Res. , 2 : 89 – 104 .
  • McFarland , J. W. 1970 . On the parabolic relationship between drug potency and hydrophobicity, . J. Med. Chem. , 13 : 1092 – 1196 .
  • Karelson , M. , Lobanov , V. S. and Katritzky , A. R. 1996 . Quantum-chemical descriptors in QSAR QSPR studies, . Chem. Rev. , 96 : 1027 – 1043 .
  • Mekenyan , O. G. and Veith , G. D. 1994 . The electronic factor in QSAR: MO-parameters, competing interactions, reactivity, and toxicity . SAR QSAR Environ. Res. , 2 : 129 – 143 .
  • Karabunarliev , S. , Mekenyan , O. G. , Karcher , W. , Russom , C. L. and Bradbury , S. P. 1996 . Quantum-chemical descriptors for estimating the acute toxicity of substituted benzenes to the guppy (Poecilia reticulata) and fathead minnow (Pimephales promelas . Quant. Struct.-Act. Relat. , 15 : 311 – 320 .
  • Cronin , M. T. D. , Gregory , B. W. and Schultz , T. W. 1998 . Quantitative structure-activity analyses of nitrobenzene toxicity to . Tetrahymena pyriformis, Chem. Res. Toxicol. , 11 : 902 – 908 .
  • Schultz , T. W. 1999 . Structure-toxicity relationships for benzenes evaluated with . Tetrahymena pyriformis, Chem. Res. Toxicol. , 12 : 1262 – 1267 .
  • Schultz , T. W. , Sinks , G. D. and Cronin , M. T. D. 1997 . “ Structure-toxicity evaluation of phenols: A mechanism of action approach, In: Quantitative Structure-Activity Relationships in Environmental Sciences-VII ” . Edited by: Fredenslund , F. C. and Schéérmann , G. 329 – 342 . Pensacola, FL, , USA : SETAC Press .
  • Veith , G. D. and Mekenyan , O. G. 1993 . A QSAR approach for estimating the aquatic toxicity of soft electrophiles (QSAR for soft electrophiles), . Quant. Struct.-Act. Relat. , 12 : 349 – 356 .
  • Cronin , M. T. D. and Schultz , T. W. 1996 . Structure-toxicity relationships for phenols to . Tetrahymena pyriformis, Chemosphere , 32 : 1453 – 1468 .
  • Schultz , T. W. and Moulton , B. A. 1985 . Structure-activity relationships for nitrogen-containing aromatics, . Environ. Toxicol. Chem. , 4 : 353 – 359 .
  • Schultz , T. W. and Applehans , F. M. 1985 . Correlations for the acute toxicity of multiple nitrogen substituted aromatic molecules, . Ecotoxicol. Environ. Saf. , 10 : 75 – 85 .
  • Schultz , T. W. , Dawson , D. A. and Lin , D. T. 1989 . Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems . Chemosphere , 18 : 2283 – 2291 .
  • Schultz , T. W. 1997 . TETRATOX: The Tetrahymena pyriformis population growth impairment endpoint, A surrogate for fish lethality . Toxicol. Meth. , 7 : 289 – 309 .
  • 1989 . “ SAS/STAT User's Guide ” . fourth edition Vol. 2 , 846 Cary, NC : SAS (Statistical Analysis System) Institute, Inc. . version 6
  • Leo , A. , Hansch , C. and Elkins , D. 1971 . Partition coefficients and their uses . Chem. Rev. , 71 : 526
  • Hansch , C. , Leo , A. and Hoekman , D. 1995 . “ Exploring QSAR Hydrophobic, Electromic, and Steric Constants ” . 348 Washington, D.C. : ACS Professional Reference Book American Chemical Society .
  • Stewart , J. J. P. 1990 . MOPAC Manual , 6th edn 189 USA : Frank J. Seiler Research Laboratory, U.S. Air Force Academy, Colorado Springs, CO .
  • Weininger , D. 1988 . SMILES, a chemical language and information-system 1, Introduction to methodology and encoding rules, . J. Chem. Inf. Comput. Sci. , 28 : 31 – 36 .
  • Vinter , J. G. , Davis , A. and Sanders , M. R. 1987 . Strategic approaches to drug design. I., An integrated software framework for molecular modeling, . J. Comput.-Aid. Molec. Design , 1 : 31 – 51 .
  • Morley , S. D. , Abraham , R. J. , Haworth , I. S. , Jackson , D. E. , Saunders , M. R. and Vinter , J. G. 1991 . COSMIC(90): An improved molecular mechanics treatment of hydrocarbons and conjugated systems, . J. Comput.-Aid. Molec. Design , 5 : 475 – 504 .
  • Karabunarliev , S. , Mekenyan , O. G. , Karcher , W. , Russom , C. L. and Bradbury , S. P. 1996 . Quantum-chemical descriptors for estimating the acute toxicity of electrophiles to the fathead minnow (Pimephales promelas): An analysis based on molecular mechanisms . Quant. Struct.-Act. Relat. , 15 : 320 – 310 .
  • Lipnick , R. L. , Watson , K. R. and Strausz , A. K. 1987 . A QSAR study of the acute toxicity of some industrial organic chemicals to goldfish, Narcosis, electrophile, and proelectrophile mechanisms, . Xenobiotica , 17 : 1011 – 1025 .
  • Schultz , T. W. , Sinks , G. D. and Bearden , A. P. 1998 . “ QSARs in aquatic toxicology: A mechanism of action approach comparing toxic potency to Pimephales promelas, Tetrahymena pyriformis, and Vibrio fischeri ” . In Comparative QSARs , Edited by: Devillers , J. 51 – 109 . Taylor and Francis .
  • Bearden , A. P. , Gregory , B. W. and Schultz , T. W. 1997 . Population growth kinetics of to Tetrahymena pyriformis exposed to selected nonpolar narcotics . Arch. Environ. Contam. Toxicol. , 33 : 401 – 406 .
  • Seward , J. R. , Sinks , G. D. and Schultz , T. W. 2000 . Population growth kinetics of Tetrahymena pyriformis exposed to selected pyridines . Eur. J. Protistology , (in press)
  • Bradbury , S. P. and Lipnick , R. L. 1990 . Introduction: Structural properties for determining mechanisms of toxic action, . Environ. Health Perspect. , 87 : 181 – 182 .
  • van Wezel , A. P. and Opperhuizen , A. 1995 . Narcosis due to environmental pollutants in aquatic organisms: Residue-based toxicity, mechanisms, and membrane burdens, . Crit. Rev. Toxicol. , 25 : 255 – 279 .
  • Abernethy , S. G. , MacKay , D. and McCarty , L. S. 1988 . Volume fraction correlation for narcosis in aquatic organisms: The key role of partitioning, . Environ. Toxicol. Chem. , 7 : 469 – 481 .
  • Franks , N. B. and Lieb , W. R. 1990 . Mechanism of general anesthesia, . Environ. Health Perspect. , 8 : 199 – 205 .
  • Bearden , A. P. , Sinks , G. D. and Schultz , T. W. 1999 . Acclimation to sublethal exposure to a model nonpolar narcotic: Population growth kinetics and membrane lipid alterations in . Tetrahymena pyriformis. Aquat. Toxicol. , 46 : 11 – 21 .
  • Schultz , T. W. 1989 . “ Nonpolar narcosis: A review of the mechanism of action for baseline toxicity, In: Aquatic Toxicology and Environmental Fate: Twelfth Volume, ASTM STP 1027 ” . Edited by: Cowgill , U. M. and Williams , L. R. 104 – 109 . Philadelphia, PA : American Society for Methods and Materials .
  • Könemann , H. 1981 . Quantitative structure-activity relationships in fish toxicity studies, Part I: A relationship for 50 industrial pollutants, . Toxicology , 19 : 209 – 221 .
  • Veith , G. D. , Call , K. and Brooke , L. 1983 . Structure-toxicity relationships for the fathead minnow, Pimephales promelas: Narcotic industrial chemicals . Can. J. Fish. Aquat. Sci. , 40 : 743 – 748 .
  • Hermens , J. L. M. 1990 . Electrophiles and acute toxicity to fish, . Environ. Health Perspect. , 87 : 219 – 225 .
  • Lipnick , R. L. 1991 . Outliers: Their origin and use in the classification of molecular mechanisms of toxicity . Sci. Total Environ. , 109/110 : 131 – 153 .
  • Veith , G. D. and Broderius , S. J. 1990 . Rules for distinguishing toxicants that cause type I and type II narcosis syndromes . Environ. Health Perspect. , 87 : 207 – 211 .
  • Schultz , T. W. , Holcombe , G. W. and Phipps , G. L. 1986 . Relationships of quantitative structure-activity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems . Ecotoxicol. Environ. Saf. , 12 : 146 – 153 .
  • Veith , G. D. and Broderius , S. J. 1987 . “ Structure-toxicity relationships for industrial chemicals causing type II narcosis syndrome ” . In QSAR in Environmental Toxicology-II , Edited by: Kaiser , K. L. E. 385 – 391 . Dordrecht : D. Reidel Publishing .
  • Verhaar , H. J. M. , van Leeuwen , C. J. and Hermens , J. L. M. 1992 . Classifying environmental pollutants, I: Structure-activity relationships for prediction of aquatic toxicity . Chemosphere , 25 : 471 – 491 .
  • Vaes , W. H. J. , Urrestarazu-Ramos , E. , Verhaar , H. J. M. and Hermens , J. L. M. 1998 . Acute toxicity of nonpolar vs. polar narcosis: is there a difference? . Environ. Toxicol. Chem. , 17 : 1380 – 1384 .
  • Bearden , A. P. and Schultz , T. W. 1997 . Structure-activity relationships for Pimephales and Tetrahymena: A mechanism of action approach . Environ. Toxicol. Chem. , 16 : 1311 – 1317 .
  • Bearden , A. P. and Schultz , T. W. 1998 . Comparison of Tetrahymena and Pimephales toxicity based on mechanism of action . SAR QSAR Environ. Res. , 9 : 127 – 153 .
  • Schultz , T. W. , Lin , D. T. , Wilke , T. S. and Arnold , L. M. 1990 . “ Quantitative structure-activity relationships for the Tetrahymena pyriformis population growth endpoint: A mechanism of toxic action approach, In: Practical Applications of Quantitative Structure-Activity Relationships (QSARin Environmental Chemistry and Toxicology ” . Edited by: Karcher , W. and Devillers , J. 241 – 262 . Dordrecht : Kluwer Academic Publishers .
  • Nendza , M. and Russom , C. L. 1991 . QSAR modeling of the ERL-D fathead minnow acute toxicity database . Xenobiotica , 21 : 147 – 170 .
  • Russom , C. L. , Bradbury , S. P. , Broderius , S. J. , Hammermeister , D. E. and Drummond , R. A. 1997 . Predicting modes of toxic action from chemical structure: Acute toxicity in the fathead minnow (Pimephales promelas . Environ. Toxicol. Chem. , 16 : 948 – 967 .
  • Klopman , G. 1974 . “ The generalized perturbation theory of chemical reactivity and its application ” . In Chemical reactivity and reaction paths , Edited by: Klopman , G. 55 – 166 . New York : John Wiley and Sons .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.