L-Arginine Supplementation in Patients with Gestational Hypertension: A Pilot Study

REFERENCES

• Lowe DT. Nitric oxide dysfunction in the pathophisiology of preeclampsia. Nitric Oxide 2000; 4: 441–458
   PubMed Web of Science ®Google Scholar
• Yallampalli C, Garfield RE. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia. Am J Obstet Gynecol 1993; 169: 1316–1320
   PubMed Web of Science ®Google Scholar
• Molnar M, Suto T, Toth T, Hertelendy F. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia and intrauterine growth retardation. Am J Obstet Gynecol 1994; 70: 1458–1466
   Google Scholar
• Diket AL, Pierce MR, Munshi UK, Voelker KA, Eloby-Childress SS, et al. Nitric oxide inhibition causes intrauterine growth retardation and hind-limb distruptions in rats. Am J Obstet Gynecol 1994; 171: 1243–1250
   PubMed Web of Science ®Google Scholar
• Boccardo P, Soregaroli M, Aiello S, Noris M, Donadelli R, Lojacono A, et al. Systemic and fetal-maternal nitric oxide synthesis in normal pregnancy and preeclampsia. Br J Obstet Gynaecol 1996; 103: 879–886
   PubMedGoogle Scholar
• Seligman SP, Buyon JP, Clancy RM, Young BK, Abramson SB. The role of nitric oxide in the pathogenesis of preeclampsia. Am J Obstet Gynecol 1994; 171: 944–948
   PubMed Web of Science ®Google Scholar
• Brown MA, Tibben E, Zammit VC, Cario GM, Carlton MA. Nitric oxide excretion in normal and hypertensive pregnancy. Am J Obstet Gynecol 1996; 175: 1013–1017
   PubMedGoogle Scholar
• Davidge ST, Stranko CP, Roberts JM. Urine but not plasma Nitric oxide metabolites are decreased in women with preeclampsia. Am J Obstet Gynecol 1996; 174: 1008–1013
   PubMed Web of Science ®Google Scholar
• Smarason AK, Allman KG, Young D, Redman CW. Elevated levels of serum nitrate, a stable and product of nitric oxide, in women with preeclampsia. Br J Ostet Gynecol 1997; 104: 538–543
   PubMedGoogle Scholar
• Di Iorio R, Marinoni E, Coacci F, La Torre R, Cosmi EV. Amniotic fluid nitric oxide and uteroplacental blood flow in pregnancy complicated by intrauterine growth retardation. Br J Obstet Gynecol 1997; 104: 1134–1139
   PubMedGoogle Scholar
• Benedetto C, Marozio L, Neri I, Giarola M, Volpe A, Facchinetti F. Increased L‐citrulline/L-arginine plasma ratio in severe preeclampsia. Obstet Gynecol 2000; 96: 395–399
   PubMed Web of Science ®Google Scholar
• Buhimischi I, Yallampalli C, Chwalisz K, Garfield RE. Preeclampsia-like conditions produced by nitric oxide inhibition: Effects of L-arginine, D-arginine and steroid hormones. Hum Reprod 1995; 10: 2723–2730
   PubMedGoogle Scholar
• Helmbrecht GD, Farhat MY, Lochbaum L, et al. L-arginine reverses the adverse pregnancy chenges induced by Nitric Oxide synthase inhibition in the rat. Am J Obstet Gynecol 1996; 175: 800–805
   PubMed Web of Science ®Google Scholar
• Ramsay B, De Belder A, Campbell S, Moncada S, Martins JF. A Nitric oxide donor improves uterine artery diastolic blood flow in normal early pregnancy and in women at high risk of preeclampsia. Eur J Clin Invest 1994; 24: 76–78
   PubMed Web of Science ®Google Scholar
• Grunewald C, Kublickas M, Carlstrom K, Lunell N-O, Nisell H. Effects of nitroglycerine on the uterine and umbilical circulation in severe preeclampsia. Obstet Gynecol 1995; 86: 600–604
   PubMed Web of Science ®Google Scholar
• Neri I, Mazza V, Galassi MC, Volpe A, Facchinetti F. Effects of L-arginine on utero-placental circulation in growth-retarded fetuses. Acta Obstet Gynecol Scand 1996; 75: 208–212
   PubMed Web of Science ®Google Scholar
• Sieroszewiski P, Suzin J, Karowicz-Bilinska A. Ultrasound evaluation of the intrauterine growth retardation therapy with NO donor (L-arginine). Ginekol Pol 2004; 75: 913–918
   PubMedGoogle Scholar
• Thaler I, Amit A, Jakobi P, Eldor J. The effect of isosorbide dinitrate on uterine artery and umbilical artery flow velocity waveforms at mid-pregnancy. Obstet Gynecol 1996; 88: 838–843
   PubMedGoogle Scholar
• Facchinetti F, Longo M, Piccinini F, Neri I, Volpe A. L-Arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol Invest 1999; 6: 202–207
   PubMedGoogle Scholar
• Neri I, Valensise H, Facchinetti F, Menghini S, Romanini C, Volpe A. 24-hour ambulatory blood pressure monitoring: a comparison between transdermal glyceryl-trinitrate and oral nifedipine. Hypertens Preg 1999; 18: 107–113
   PubMed Web of Science ®Google Scholar
• Neri I, Marietta M, Piccinini F, Volpe A, Facchinetti F. The L-arginine-nitric oxide system regulates platelet aggregation in pregnancy. J Soc Gynecol Invest 1998; 5: 192–196
   PubMedGoogle Scholar
• Neri I, Piccinini F, Marietta M, Facchinetti F, Volpe A. Platelet responsiveness to L-Arginine in hypertensive disorders of pregnancy. Hypertens pregnancy 2000; 19: 323–330
   PubMed Web of Science ®Google Scholar
• Neri I, Jasonni VM, Gori GF, Blasi I, Facchinetti F, the Arginine Study Group. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Mat-Fetal Neonat Med 2006; 19: 277–281
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109–142
   PubMed Web of Science ®Google Scholar
• Smulders RA, Aarsen M, Teerlink T, De Vries PMJM, Van Kamp GJ, Donker AJM, Stehouwer CDA. Haemodynamic and biochemical response to L-Arg and L‐Lysine infusion in normal subjects: L-Arg-induced vasodilatation cannot be explained by non-specific effects of cationic amino acids. Clin Sci 1997; 92: 367–374
   Google Scholar
• Myatt L, Rosenfield RB, Eis AL, Brockman DE, Greer I, Lyall F. Nitrotyrosine residues in placenta. Evidence of peroxynitrate formation and action. Hypertension 1996; 28: 488–493
   PubMed Web of Science ®Google Scholar
• Davidge ST. Oxidative stress and altered endothelial cell function in preeclampsia. Semin Reprod Endocrinol 1998; 16: 65–73
   PubMedGoogle Scholar
• Roggensack AM, Zhang Y, Davidge ST. Evidence for peroxynitrite formation in the vasculature of women with preeclampsia. Hypertension 1999; 33: 83–89
   PubMed Web of Science ®Google Scholar
• Ronzoni S, Marconi AM, Cetin I, Paolini CL, Teng C, Pardi G, et al. Umbilical amino acid uptake at increasing maternal amnio acid concentrations: Ettect of maternal amnio acid infusate. Am J Obstet Gynecol 1999; 181: 477–483
   PubMed Web of Science ®Google Scholar
• Ayuk TY, Theophanous D, D'souza SW, Sibley CP, Glazier JD. Arginine trasport by microvillous plasma membrane of the syncytiotrophoblast from human placenta in relation to nitric oxide production: effects of gestation, preeclampsia, and intrauterine growth restriction. J Clin Endocrinol Metab 2002; 87: 747–751
   PubMedGoogle Scholar
• Neri I, Blasi I, Facchinetti F. Effects of acute L-arginine infusion on non-stress test in hypertension pregnant women. J Mat-Fetal Neonat Med 2004; 16: 23–26
   PubMedGoogle Scholar
• Gardner DS, Abigail L, Giussani DA. Adverse intrauterine conditions diminish the foetal defense against acute hypoxia by increasing nitric oxide activity. Circulation 2002; 106: 2278–2283
   PubMed Web of Science ®Google Scholar
• Germain AM, Valdes G, Romanik MC, Reyes MS. Evidence supporting a beneficial role for long-term L-arginine supplementation oin high risk pregnancies. Hypertension 2004; 43: e1
   PubMedGoogle Scholar
• Rytlewski K, Olszanecki R, Korbut R, Zdebski Z. Effects of prolonged oral supplementation with L-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest 2005; 35: 32–37
   PubMed Web of Science ®Google Scholar
• Staff AC, Berge L, Lorentzen B, Mikkelsen B, Henriksen T. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004; 83: 103–107
   PubMed Web of Science ®Google Scholar
• Saudan P, Brown MA, Buddle ML, Jones M. Does gestational hypertension become pre-eclampsia?. Br J Obstet Gynaecol 1998; 105: 1177–1184
   PubMedGoogle Scholar