mRNA levels of circadian clock components Bmal1 and Per2 alter independently from dosing time-dependent efficacy of combination treatment with valsartan and amlodipine in spontaneously hypertensive rats

References

• Portaluppi F, Smolensky MH. Perspectives on the chronotherapy of hypertension based on the results of the MAPEC study. Chronobiol Int 2010;27:1652–67.
   PubMed Web of Science ®Google Scholar
• Zhao P, Xu P, Wan C, et al. Evening versus morning dosing regimen drug therapy for hypertension. Cochrane Database Syst Rev 2011;CD004184.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Calvo C, Ayala DE, et al. Administration time-dependent effects of valsartan on ambulatory blood pressure in hypertensive subjects. Hypertension 2003;42:283–90.
   PubMed Web of Science ®Google Scholar
• Potucek P, Klimas J. Chronotherapy of hypertension with combination treatment. Pharmazie 2013;68:921–25.
   PubMed Web of Science ®Google Scholar
• Qiu YG, Chen JZ, Zhu JH, et al. Differential effects of morning or evening dosing of amlodipine on circadian blood pressure and heart rate. Cardiovasc Drugs Ther 2003;17:335–41.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Fontao MJ, et al. Chronotherapy with valsartan/amlodipine fixed combination: improved blood pressure control of essential hypertension with bedtime dosing. Chronobiol Int 2010;27:1287–303.
   PubMed Web of Science ®Google Scholar
• Asmar R, Gosse P, Quere S, et al. Efficacy of morning and evening dosing of amlodipine/valsartan combination in hypertensive patients uncontrolled by 5 mg of amlodipine. Blood Press Monit 2011;16:80–86.
   PubMed Web of Science ®Google Scholar
• Liu Y, Ushijima K, Ohmori M, et al. Chronopharmacology of angiotensin II-receptor blockers in stroke-prone spontaneously hypertensive rats. J Pharmacol Sci 2011;115:196–204.
   PubMed Web of Science ®Google Scholar
• Mattes A, Lemmer B. Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats. Chronobiol Int 1991;8:526–38.
   PubMed Web of Science ®Google Scholar
• Millar-Craig MW, Bishop CN, Raftery EB. Circadian variation of blood-pressure. Lancet 1978;1:795–97.
   PubMed Web of Science ®Google Scholar
• Alibhai FJ, Tsimakouridze EV, Reitz CJ, et al. Consequences of circadian and sleep disturbances for the cardiovascular system. Can J Cardiol 2015;31:860–72.
   PubMed Web of Science ®Google Scholar
• Davidson AJ, London B, Block GD, et al. Cardiovascular tissues contain independent circadian clocks. Clin Exp Hypertens 2005;27:307–11.
   PubMed Web of Science ®Google Scholar
• Pati P, Fulton DJ, Bagi Z, et al. Low-salt diet and circadian dysfunction synergize to induce angiotensin II-dependent hypertension in mice. Hypertension 2016;67:661–68.
   PubMed Web of Science ®Google Scholar
• Takeda N, Maemura K. Cardiovascular disease, chronopharmacotherapy, and the molecular clock. Adv Drug Deliv Rev 2010;62:956–66.
   PubMed Web of Science ®Google Scholar
• Martino TA, Sole MJ. Molecular time: an often overlooked dimension to cardiovascular disease. Circ Res 2009;105:1047–61.
   PubMed Web of Science ®Google Scholar
• Takahashi JS, Hong HK, Ko CH, et al. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 2008;9:764–75.
   PubMed Web of Science ®Google Scholar
• Young ME, Razeghi P, Taegtmeyer H. Clock genes in the heart: characterization and attenuation with hypertrophy. Circ Res 2001;88:1142–50.
   PubMed Web of Science ®Google Scholar
• Richards J, Diaz AN, Gumz ML. Clock genes in hypertension: novel insights from rodent models. Blood Press Monit 2014;19:249–54.
   PubMed Web of Science ®Google Scholar
• Woon PY, Kaisaki PJ, Braganca J, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A 2007;104:14412–17.
   PubMed Web of Science ®Google Scholar
• Anea CB, Cheng B, Sharma S, et al. Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice. Circ Res 2012;111:1157–65.
   PubMed Web of Science ®Google Scholar
• Curtis AM, Cheng Y, Kapoor S, et al. Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci U S A 2007;104:3450–55.
   PubMed Web of Science ®Google Scholar
• Durgan DJ, Tsai JY, Grenett MH, et al. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int 2011;28:187–203.
   PubMed Web of Science ®Google Scholar
• Lefta M, Campbell KS, Feng HZ, et al. Development of dilated cardiomyopathy in Bmal1-deficient mice. Am J Physiol Heart Circ Physiol 2012;303:H475–85.
   PubMed Web of Science ®Google Scholar
• Martino TA, Tata N, Belsham DD, et al. Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension 2007;49:1104–13.
   PubMed Web of Science ®Google Scholar
• Bonney S, Kominsky D, Brodsky K, et al. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. Plos One 2013;8:e71493.
   PubMed Web of Science ®Google Scholar
• Virag JA, Dries JL, Easton PR, et al. Attenuation of myocardial injury in mice with functional deletion of the circadian rhythm gene mPer2. Am J Physiol Heart Circ Physiol 2010;298:H1088–95.
   PubMed Web of Science ®Google Scholar
• Viswambharan H, Carvas JM, Antic V, et al. Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation 2007;115:2188–95.
   PubMed Web of Science ®Google Scholar
• Vukolic A, Antic V, Van VBN, et al. Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms. Am J Physiol Regul Integr Comp Physiol 2010;298:R627–34.
   PubMed Web of Science ®Google Scholar
• Klimas J, Olvedy M, Ochodnicka-Mackovicova K, et al. Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats. J Cell Mol Med 2015;19:1965–74.
   PubMed Web of Science ®Google Scholar
• Klimas J, Stankovicova T, Kyselovic J, et al. Prolonged QT interval is associated with blood pressure rather than left ventricular mass in spontaneously hypertensive rats. Clin Exp Hypertens 2008;30:475–85.
   PubMed Web of Science ®Google Scholar
• Klimas J, Vaja V, Vercinska M, et al. Discrepant regulation of QT (QTc) interval duration by calcium channel blockade and angiotensin converting enzyme inhibition in experimental hypertension. Basic Clin Pharmacol Toxicol 2012;111:279–88.
   PubMed Web of Science ®Google Scholar
• Vaja V, Ochodnicky P, Krenek P, et al. Rapid large artery remodeling following the administration and withdrawal of calcium channel blockers in spontaneously hypertensive rats. Eur J Pharmacol 2009;619:85–91.
   PubMed Web of Science ®Google Scholar
• Braun MC, Herring SM, Gokul N, et al. Hypertensive renal disease: susceptibility and resistance in inbred hypertensive rat lines. J Hypertens 2013;31:2050–59.
   PubMed Web of Science ®Google Scholar
• Collins HE, Turrell HE, Samani NJ, et al. Diurnal variation in excitation-contraction coupling is lost in the adult spontaneously hypertensive rat heart. J Hypertens 2013;31:1214–23.
   PubMed Web of Science ®Google Scholar
• Cui H, Kohsaka A, Waki H, et al. Metabolic cycles are linked to the cardiovascular diurnal rhythm in rats with essential hypertension. Plos One 2011;6:e17339.
   PubMed Web of Science ®Google Scholar
• Naito Y, Tsujino T, Kawasaki D, et al. Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats. J Hypertens 2003;21:1107–15.
   PubMed Web of Science ®Google Scholar
• Ohdo S. Chronotherapeutic strategy: rhythm monitoring, manipulation and disruption. Adv Drug Deliv Rev 2010;62:859–75.
   PubMed Web of Science ®Google Scholar
• Olejnikova L, Polidarova L, Pauslyova L, et al. Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease. Chronobiol Int 2015;32:531–47.
   PubMed Web of Science ®Google Scholar
• Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365–86.
   PubMedGoogle Scholar
• Ruijter JM, Ramakers C, Hoogaars WM, et al. Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res 2009;37:e45.
   PubMed Web of Science ®Google Scholar
• Dong YF, Kataoka K, Tokutomi Y, et al. Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats. J Pharmacol Exp Ther 2011;339:358–66.
   PubMed Web of Science ®Google Scholar
• Webb R, Yao N, Thoma M, et al. The chronic effects of valsartan with amlodipine on blood pressure and cardiac mass in spontaneously hypertensive rats (SHR). J Hypertens 2000;18:S80–S80.
   Google Scholar
• Herichova I, Mravec B, Stebelova K, et al. Rhythmic clock gene expression in heart, kidney and some brain nuclei involved in blood pressure control in hypertensive TGR(mREN-2)27 rats. Mol Cell Biochem 2007;296:25–34.
   PubMed Web of Science ®Google Scholar
• Mohri T, Emoto N, Nonaka H, et al. Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet. Hypertension 2003;42:189–94.
   PubMed Web of Science ®Google Scholar
• Zeman M, Szantoova K, Stebelova K, et al. Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats. J Hypertens Suppl 2009;27:S21–6.
   PubMedGoogle Scholar
• Veglio F, Pietrandrea R, Ossola M, et al. Circadian rhythm of the angiotensin converting enzyme (ACE) activity in serum of healthy adult subjects. Chronobiologia 1987;14:21–25.
   PubMedGoogle Scholar
• Kyselovic J, Krenek P, Wibo M, et al. Effects of amlodipine and lacidipine on cardiac remodelling and renin production in salt-loaded stroke-prone hypertensive rats. Br J Pharmacol 2001;134:1516–22.
   PubMed Web of Science ®Google Scholar
• Herichova I, Soltesova D, Szantoova K, et al. Effect of angiotensin II on rhythmic per2 expression in the suprachiasmatic nucleus and heart and daily rhythm of activity in Wistar rats. Regul Pept 2013;186:49–56.
   PubMedGoogle Scholar
• Nonaka H, Emoto N, Ikeda K, et al. Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells. Circulation 2001;104:1746–48.
   PubMed Web of Science ®Google Scholar
• Wu J, Sigmund CD. Hypertension: A disease that strikes around the clock. Hypertension 2016;67:493–95.
   PubMed Web of Science ®Google Scholar
• Ingle KA, Kain V, Goel M, et al. Cardiomyocyte-specific Bmal1 deletion in mice triggers diastolic dysfunction, extracellular matrix response, and impaired resolution of inflammation. Am J Physiol Heart Circ Physiol 2015;309:H1827–36.
   PubMed Web of Science ®Google Scholar
• Schoenhard A, Smith LH, Painter CA, et al. Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2. J Mol Cell Cardiol 2003;35:473–81.
   PubMed Web of Science ®Google Scholar
• Ghosh AK, Vaughan DE. PAI-1 in tissue fibrosis. J Cell Physiol 2012;227:493–507.
   PubMed Web of Science ®Google Scholar
• Takeshita K, Hayashi M, Iino S, et al. Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction. Am J Pathol 2004;164:449–56.
   PubMed Web of Science ®Google Scholar
• Gupta KK, Donahue DL, Sandoval-Cooper MJ, et al. Plasminogen activator inhibitor-1 protects mice against cardiac fibrosis by inhibiting urokinase-type plasminogen activator-mediated plasminogen activation. Sci Rep 2017;7:365.
   PubMed Web of Science ®Google Scholar
• Knier B, Cordasic N, Klanke B, et al. Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage. J Hypertens 2011;29:1602–12.
   PubMed Web of Science ®Google Scholar
• Tsukamoto-Yamauchi N, Terasaka T, Iwasaki Y, et al. Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin. Biochem Biophys Res Commun 2015;459:172–77.
   PubMed Web of Science ®Google Scholar