Hyperinsulinemia rather than insulin resistance itself induces blood pressure elevation in high fat diet-fed rats

References

• Welborn TA , Breckenridge A , Rubinstein AH , Dollery CT , Fraser TR. 1966. Serum-insulin in essential hypertension and in peripheral vascular disease. Lancet. 1(7451):1336–37. doi:10.1016/s0140-6736(66)92132-5.
   PubMed Web of Science ®Google Scholar
• Dengel DR , Pratley RE , Hagberg JM , Goldberg AP . 1994. Impaired insulin sensitivity and maximal responsiveness in older hypertensive men. Hypertension. 23(3):320–24. doi:10.1161/01.hyp.23.3.320.
   PubMed Web of Science ®Google Scholar
• Pollare T , Lithell H , Berne C . 1990. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism. 39(2):167–74. doi:10.1016/0026-0495(90)90071-j.
   PubMed Web of Science ®Google Scholar
• Genovesi S , Brambilla P , Giussani M , Galbiati S , Mastriani S , Pieruzzi F , Stella A , Valsecchi MG , Antolini L . 2012. Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. J Hypertens. 30(2):327–35. doi:10.1097/HJH.0b013e32834e4aaa.
   PubMed Web of Science ®Google Scholar
• Song J , Hu X , Riazi S , Tiwari S , Wade JB , Ecelbarger CA . 2006. Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats. Am J Physiol Renal Physiol. 290(5):F1055–1064. doi:10.1152/ajprenal.00108.2005.
   PubMed Web of Science ®Google Scholar
• Zavaroni I , Bonini L , Gasparini P , Barilli AL , Zuccarelli A , Dall’Aglio E , Delsignore R , Reaven GM . 1999. Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: the Barilla factory revisited. Metabolism. 48(8):989–94. doi:10.1016/s0026-0495(99)90195-6.
   PubMed Web of Science ®Google Scholar
• Salonen JT , Lakka TA , Lakka HM , Valkonen VP , Everson SA , Kaplan GA . 1998. Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes. 47(2):270–75. doi:10.2337/diab.47.2.270.
   Web of Science ®Google Scholar
• Mioni R , Ca AD , Turra J , Azzolini S , Xamin N , Bleve L , Maffei P , Vettor R , Fallo F . 2017. Hyperinsulinemia and obese phenotype differently influence blood pressure in young normotensive patients with polycystic ovary syndrome. Endocrine. 55(2):625–34. doi:10.1007/s12020-016-0958-x.
   PubMed Web of Science ®Google Scholar
• Brands MW , Bell TD , Rodriquez NA , Polavarapu P , Panteleyev D . 2009. Chronic glucose infusion causes sustained increases in tubular sodium reabsorption and renal blood flow in dogs. Am J Physiol Regul Integr Comp Physiol. 296(2):R265–271. doi:10.1152/ajpregu.90528.2008.
   Web of Science ®Google Scholar
• Johansson ME , Andersson IJ , Alexanderson C , Skott O , Holmang A , Bergstrom G . 2008. Hyperinsulinemic rats are normotensive but sensitized to angiotensin II. Am J Physiol Regul Integr Comp Physiol. 294(4):R1240–1247. doi:10.1152/ajpregu.00493.2007.
   PubMed Web of Science ®Google Scholar
• Verma S , Leung YM , Yao L , Battell M , Dumont AS , McNeill JH . 2001. Hyperinsulinemia superimposed on insulin resistance does not elevate blood pressure. Am J Hypertens. 14(5):429–32. doi:10.1016/s0895-7061(00)01261-9.
   PubMed Web of Science ®Google Scholar
• Li GW , Wang JP , Li CM , Chen YY , Yang WY , Xing XY , Liu KL , Tang YL , Li H . 2004. Anti-hypertensive effect of rosiglitazone in non-diabetic essential hypertension. Chin J Intern Med. 43(12):907–10.
   Google Scholar
• Honisett SY , Stojanovska L , Sudhir K , Kingwell BA , Dawood T , Komesaroff PA . 2003. Rosiglitazone lowers blood pressure and increases arterial compliance in postmenopausal women with type 2 diabetes. Diabetes Care. 26(11):3194–95. doi:10.2337/diacare.26.11.3194.
   PubMed Web of Science ®Google Scholar
• Shargorodsky M , Wainstein J , Gavish D , Leibovitz E , Matas Z , Zimlichman R . 2003. Treatment with rosiglitazone reduces hyperinsulinemia and improves arterial elasticity in patients with type 2 diabetes mellitus. Am J Hypertens. 16(8):617–22. doi:10.1016/S0895-7061(03)00911-7.
   PubMed Web of Science ®Google Scholar
• Anan F , Masaki T , Fukunaga N , Teshima Y , Iwao T , Kaneda K , Umeno Y , Okada K , Wakasugi K , Yonemochi H , et al. 2007. Pioglitazone shift circadian rhythm of blood pressure from non-dipper to dipper type in type 2 diabetes mellitus. Eur J Clin Invest. 37(9):709–14. doi:10.1111/j.1365-2362.2007.01854.x.
   PubMed Web of Science ®Google Scholar
• de Rivas B , Luque M , Martell N , Fernández C , Fernández-Cruz A . 2007. Pioglitazone decreases ambulatory blood pressure in type 2 diabetics with difficult-to-control hypertension. J Clin Hypertens. 9(7):530–37. doi:10.1111/j.1524-6175.2007.06694.x.
   Google Scholar
• Gerber P , Lübben G , Heusler S , Dodo A . 2003. Effects of pioglitazone on metabolic control and blood pressure: a randomised study in patients with type 2 diabetes mellitus. Curr Med Res Opin. 19(6):532–39. doi:10.1185/030079903125002180.
   PubMed Web of Science ®Google Scholar
• Rocchini AP . 2000. Obesity hypertension, salt sensitivity and insulin resistance. Nutr Metab Cardiovasc Dis. 10(5):287–94.
   PubMed Web of Science ®Google Scholar
• Chen W , Chang Y , He L , Jian X , Li L , Gao L , Yang Y , Zeng M , Liu H , Zhao AZ , et al. 2016. Effect of renal sympathetic denervation on hepatic glucose metabolism and blood pressure in a rat model of insulin resistance. J Hypertens. 34(12):2465–74. doi:10.1097/hjh.0000000000001087.
   PubMed Web of Science ®Google Scholar
• Kashyap SR , Defronzo RA . 2007. The insulin resistance syndrome: physiological considerations. Diab Vasc Dis Res. 4(1):13–19. doi:10.3132/dvdr.2007.001.
   Google Scholar
• Sarafidis PA , Bakris GL . 2007. Review: insulin and endothelin: an interplay contributing to hypertension development? J Clin Endocrinol Metab. 92(2):379–85. doi:10.1210/jc.2006-1819.
   Web of Science ®Google Scholar
• Banday AA , Siddiqui AH , Menezes MM , Hussain T . 2005. Insulin treatment enhances AT1 receptor function in OK cells. Am J Physiol Renal Physiol. 288(6):F1213–1219. doi:10.1152/ajprenal.00361.2003.
   Web of Science ®Google Scholar
• Zhang F , Ye C , Li G , Ding W , Zhou W , Zhu H , Chen G , Luo T , Guang M , Liu Y , et al. 2003. The rat model of type 2 diabetic mellitus and its glycometabolism characters. Exp Anim. 52(5):401–07.
   Web of Science ®Google Scholar
• Arun KH , Kaul CL , Ramarao P . 2005. AT1 receptors and L-type calcium channels: functional coupling in supersensitivity to angiotensin II in diabetic rats. Cardiovasc Res. 65(2):374–86. doi:10.1016/j.cardiores.2004.10.010.
   Web of Science ®Google Scholar
• Wang H , Li H , Hou Z , Pan L , Shen X , Li G . 2009. Role of oxidative stress in elevated blood pressure induced by high free fatty acids. Hypertens Res. 32(2):152–58. doi:10.1038/hr.2008.35.
   PubMed Web of Science ®Google Scholar
• Zhao C , Wang P , Xiao X , Chao J , Chao L , Wang DW , Zeldin DC . 2003. Gene therapy with human tissue kallikrein reduces hypertension and hyperinsulinemia in fructose-induced hypertensive rats. Hypertension. 42(5):1026–33. doi:10.1161/01.hyp.0000097603.55404.35.
   PubMed Web of Science ®Google Scholar
• Global guideline for type . 2 diabetes. Diabetes Res Clin Pract. 2014;104(1):1–52. doi:10.1016/j.diabres.2012.10.001.
   Google Scholar
• Tsimihodimos V , Gonzalez-Villalpando C , Meigs JB , Ferrannini E . 2018. Hypertension and diabetes mellitus: coprediction and time trajectories. Hypertension. 71(3):422–28. doi:10.1161/hypertensionaha.117.10546.
   PubMed Web of Science ®Google Scholar
• Sowers JR . 2004. Insulin resistance and hypertension. Am J Physiol Heart Circ Physiol. 286(5):H1597–1602. doi:10.1152/ajpheart.00026.2004.
   PubMed Web of Science ®Google Scholar
• Millen AM , Norton GR , Majane OH , Maseko MJ , Brooksbank R , Michel FS , Snyman T , Sareli P , Woodiwiss AJ . 2013. Insulin resistance and the relationship between urinary Na(+)/K(+) and ambulatory blood pressure in a community of African ancestry. Am J Hypertens. 26(5):708–16. doi:10.1093/ajh/hpt010.
   PubMed Web of Science ®Google Scholar
• Tsuchida H , Imai G , Shima Y , Satoh T , Owada S . 2001. Mechanism of sodium load-induced hypertension in non-insulin dependent diabetes mellitus model rats: defective dopaminergic system to inhibit Na-K-ATPase activity in renal epithelial cells. Hypertens Res. 24(2):127–35. doi:10.1291/hypres.24.127.
   PubMed Web of Science ®Google Scholar
• DeFronzo RA . 1981. The effect of insulin on renal sodium metabolism. A review with clinical implications. Diabetologia. 21(3):165–71. doi:10.1007/bf00252649.
   PubMed Web of Science ®Google Scholar
• Nizar JM , Dong W , McClellan RB , Labarca M , Zhou Y , Wong J , Goens DG , Zhao M , Velarde N , Bernstein D , et al. 2016. Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance. Am J Physiol Renal Physiol. 310(9):F812–820. doi:10.1152/ajprenal.00265.2015.
   PubMed Web of Science ®Google Scholar
• Verma S , Bhanot S , McNeill JH . 1999. Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension. Eur J Pharmacol. 373(2–3):R1–4. doi:10.1016/s0014-2999(99)00301-5.
   PubMed Web of Science ®Google Scholar
• van Veen S , Chang PC . 1998. Modulation of vasoconstriction by insulin. J Hypertens. 16(8):1157–64.
   Google Scholar
• Yatabe MS , Yatabe J , Yoneda M , Watanabe T , Otsuki M , Felder RA , Jose PA , Sanada H . 2010. Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension. Am J Clin Nutr. 92(1):77–82. doi:10.3945/ajcn.2009.29028.
   PubMed Web of Science ®Google Scholar
• Juan CC , Shen YW , Chien Y , Lin YJ , Chang SF , Ho LT . 2004. Insulin infusion induces endothelin-1-dependent hypertension in rats. Am J Physiol Endocrinol Metab. 287(5):E948–954. doi:10.1152/ajpendo.00536.2003.
   PubMed Web of Science ®Google Scholar
• Lin YJ , Juan CC , Kwok CF , Hsu YP , Shih KC , Chen CC , Ho LT . 2015. Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome. Biochem Biophys Res Commun. 460(3):497–503. doi:10.1016/j.bbrc.2015.03.017.
   PubMed Web of Science ®Google Scholar
• Weder AB . 1986. Red-cell lithium-sodium countertransport and renal lithium clearance in hypertension. N Engl J Med. 314(4):198–201. doi:10.1056/NEJM198601233140402.
   PubMed Web of Science ®Google Scholar
• Miyazaki Y , Shimamoto K , Ise T , Shiiki M , Higashiura K , Hirata A , Masuda A , Nakagawa M , Iimura O . 1996. Effects of hyperinsulinaemia on renal function and the pressor system in insulin-resistant obese adolescents. Clin Exp Pharmacol Physiol. 23(4):287–90. doi:10.1111/j.1440-1681.1996.tb02825.x.
   PubMed Web of Science ®Google Scholar
• Horita S , Seki G , Yamada H , Suzuki M , Koike K , Fujita T . 2011. Insulin resistance, obesity, hypertension, and renal sodium transport. Int J Hypertens. 2011:391762. doi:10.4061/2011/391762.
   PubMedGoogle Scholar