48
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Thioredoxin, an Anti-oxidant Protein, Protects Mouse Embryos from Oxidative Stress-induced Developmental Anomalies

, , &
Pages 949-956 | Published online: 07 Jul 2009

  • Cockfort, D.L. (1990) Dissection and Culture of Postimplantation Embryos (Oxford University Press, New York).
  • Ishibashi, M., Akazawa, S., Sakamaki, H., Matsumoto, K., Yamasaki, H., Yamaguchi, Y, Goto, S., Urata, Y, Kondo, T. and Nagataki, S. (1997) "Oxygen induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early organogenesis", Free Radic. Biol. Med. 22, 447-454.
  • New, D.A. and Coppola, P.T. (1970) "Development of explanted rat fetuses in hyperbaric oxygen", Teratology 3, 153-161.
  • Ferm, V.H. (1964) "Teratogenic effects of hyperbaric oxygen", Proc. Soc. Exp. Biol. Med. 116, 975-976.
  • Miller, P.D., Telford, I.R. and Haas, G.R. (1971) "Effect of hyperbaric oxygen on cardiogenesis in the rat", Biol. Neonate 17, 44-52.
  • Telford, I.R., Miller, P.D. and Haas, G.F. (1969) "Hyperbaric oxygen causes fertal wastage in rats", Lancet 2, 220-221.
  • Sapunar, D., Saraga-Babic, M, Peruzovic, M. and Marusic, M. (1993) "Effects of hyperbaric oxygen on rat embryos", Biol. Neonate 63, 360-369.
  • New, D.A. and Coppola, P.T. (1970) "Effects of different oxygen concentrations on the development of rat embryos in culture", J. Reprod. Fertil. 21, 109-118.
  • Morriss, G. and New, D.T. (1979) "Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos", J. Embryol. Exp. Morphol. 54, 17-35.
  • Chen, E.Y., Fujinaga, M. and Giaccia, A.J. (1999) "Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development", Teratology 60, 215-225.
  • Eklund, H., Cambillau, C., Sjoberg, B.M., Holmgren, A., Jornvall, H., Hoog, J.O. and Branden, C.I. (1984) "Conformational and functional similarities between glutaredoxin and thioredoxins", EMBO J. 3, 1443-1449.
  • Holmgren, A. (1985) "Thioredoxin", Annu. Rev. Biochem. 54, 237-271.
  • Holmgren, A. (1989) "Thioredoxin and glutaredoxin systems", J. Biol. Chem. 264, 13963-13966.
  • Nakamura, H., Matsuda, M., Furuke, K., Kitaoka, Y, Iwata, S., Toda, K., Inamoto, T., Yamaoka, Y, Ozawa, K. and Yodoi, J. (1994) "Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide", Immunol. Lett. 42, 75-80.
  • Nakamura, H., Nakamura, K. and Yodoi, J. (1997) "Redox regulation of cellular activation", Annu. Rev. Immunol. 15, 351-369.
  • Hirota, K., Matsui, M., Iwata, S., Nishiyama, A., Mori, K. and Yodoi, J. (1997) "AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1", Proc. Natl Acad. Sci. USA 94, 3633-3638.
  • Okamoto, T., Ogiwara, H., Hayashi, T., Mitsui, A., Kawabe, T. and Yodoi, J. (1992) "Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism", Int. Immunol. 4, 811-819.
  • Ueno, M., Masutani, H., Arai, R.J., Yamauchi, A., Hirota, K., Sakai, T., Inamoto, T., Yamaoka, Y, Yodoi, J. and Nikaido, T. (1999) "Thioredoxin-dependent redox regulation of p53-mediated p21 activation", J. Biol. Chem. 274, 35809-35815.
  • Nordberg, J. and Arner, E. (2001) "Reactive oxygen species, antioxidants, and the mammalian thioredoxin system", Free Radic. Biol. Med. 31, 1287-1312.
  • Meyer, M., Schreck, R. and Baeuerle, P.A. (1993) "H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidantresponsive factor", EMBO J. 12, 2005-2015.
  • Kobayashi, M., Nakamura, H., Yodoi, J. and Shiota, K. (2000) "Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses", Antioxid. Redox Signal. 2, 653-663.
  • Takagi, Y, Mitsui, A., Nishiyama, A., Nozaki, K., Sono, H., Gon, Y, Hashimoto, N. and Yodoi, J. (1999) "Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage", Proc. Natl Acad. Sci. USA 96, 4131-4136.
  • Klug, S., Lewandowski, C., Blankenburg, G., Merker, H.J. and Neubert, D. (1985) "Effect of acyclovir on mammalian embryonic development in culture", Arch. Toxicol. 58, 89-96.
  • Takagi, Y, Horikawa, F, Nozaki, K., Sugino, T., Hashimoto, N. and Yodoi, J. (1998) "Expression and distribution of redox regulatory protein, thioredoxin during transient focal brain ischemia in the rat", Neurosci. Lett. 251, 25-28.
  • Tomimoto, H., Akiguchi, I., Wakita, H., Kimura, J., Hori, K. and Yodoi, J. (1993) "Astroglial expression of ATL-derived factor, a human thioredoxin homologue, in the gerbil brain after transient global ischemia", Brain Res. 625, 1-8.
  • Nakamura, H., Bai, J., Nishinaka, Y, Ueda, S., Sasada, T., Ohshio, G., Imamura, M., Takabayashi, A., Yamaoka, Y. and Yodoi, J. (2000) "Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer", Cancer Detect. Prev. 24, 53-60.
  • Toyokuni, S., Tanaka, T., Hattori, Y, Nishiyama, Y, Yoshida, A., Uchida, K., Hiai, H., Ochi, H. and Osawa, T. (1997) "Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model", Lab. Investig. 76, 365-374.
  • Fantel, A.G. (1996) "Reactive oxygen species in developmental toxicity: review and hypothesis", Teratology 53, 196-217.
  • Schardein, J.L. (2000) Chemically Induced Birth Defects (Marcel Dekker, New York).
  • Shepard, T.H. (1998) Catalog of Teratogenic Agents (Johns Hopkins University Press, Baltimore).
  • Winn, L.M. and Wells, P.G. (1999) "Maternal administration of Superoxide dismutase and catalase in phenytoin teratogenicity", Free Radic. Biol. Med. 26, 266-274.
  • Eriksson, U.J., Borg, L.A., Forsberg, H. and Styrud, J. (1991) "Diabetic embryopathy. Studies with animal and in vitro models", Diabetes 40(Suppl. 2), 94-98.
  • Eriksson, U.J. and Borg, L.A. (1991) "Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro", Diabetologia 34, 325-331.
  • Trocino, R.A., Akazawa, S., Ishibashi, M., Matsumoto, K., Matsuo, H., Yamamoto, H., Goto, S., Urata, Y, Kondo, T. and Nagataki, S. (1995) "Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture", Diabetes 44, 992-998.
  • Wentzel, P., Thunberg, L. and Eriksson, U.J. (1997) "Teratogenic effect of diabetic serum is prevented by supplementation of Superoxide dismutase and N-acetylcysteine in rat embryo culture", Diabetologia 40, 7-14.
  • Matsui, M., Oshima, M., Oshima, H., Takaku, K., Maruyama, T., Yodoi, J. and Taketo, M.M. (1996) "Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene", Dev. Biol. 178, 179-185.
  • Das, K.C. and Das, C.K. (2000) "Thioredoxin, a singlet oxygen quencher and hydroxyl radical scavenger: Redox independent functions", Biochem. Biophys. Res. Commun. 277, 443-447.
  • Mitsui, A., Hirakawa, T. and Yodoi, J. (1992) "Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin", Biochem. Biophys. Res. Commun. 186, 1220-1226.
  • Chae, H.Z., Robison, K., Poole, L.B., Church, G. and Storz, G. (1994) "Cloning and sequencing of thiol-specific antioxidant from mammalian brain: Alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes", Proc. Natl Acad. Sci. USA 91, 7017-7021.
  • Netto, L., Chae, H.Z., Kang, S.W., Rhee, S.G. and Stadtman, E.R. (1996) "Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties", J. Biol. Chem. 271, 15315-15321.
  • Lewin, M.H., Hume, R., Howie, A.F., Richard, K., Arthur, J.R., Nicol, E, Walker, S.W. and Beckett, G.J. (2001) "Thioredoxin reductase and cytoplasmic glutathione peroxidase activity in human foetal and neonatal liver", Biochem. Biophys. Acta 1526, 237-241.
  • Das, K.C., Guo, X. and White, C.W. (1999) "Induction of thioredoxin reductase gene expression in lings of newborn primates by oxygen", Am. Physiol. Soc. 276, L530-L539.
  • Rozell, B., Hansson, H.A., Luthman, M. and Holmgren, A. (1985) "Immunohistochemical localization of thioredoxin and thioredoxin reductase in adult rats", Eur. J. Cell Biol. 38, 79-86.
  • Reaume, A.G., Elliott, J.L., Hoffman, E.K., Kowall, N.W., Ferrante, R.J., Siwek, D.E., Wilcox, H.M., Flood, D.L., Seal, M.F., Brown, R.H.J., Scott, R.W. and Sinder, W.D. (1996) "Motor neurons in Cu/Zn Superoxide dismutasedeficient mice develop normally but exhibit enhanced cell death after axonal injury", Nat. Genet. 13, 43-47.
  • Li, Y, Huang, T.T., Calson, E.J., Melov, S., Ursell, P.C., Olson, J.L., Noble, L.J., Yoshimura, M.P, Berger, C., Chan, PH., Wallace, D.C. and Epstein, C.J. (1995) "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese Superoxide dismutase", Nat. Genet. 11, 376-381.
  • Carlsson, L.M., Jonsson, J., Edlund, T. and Marklund, S.L. (1995) "Mice lacking extracellular Superoxide dismutase are more sensitive to hyperoxia", Proc. Natl Acad. Sci. USA 92, 6264-6268.
  • Ho, Y.S., Magnenat, J.L., Bronson, R.T., Cao, J., Gargano, M., Sugawara, M. and Funk, C.D. (1997) "Mice deficient in cellular glutathione peroxides develop normally and show no increased sensitivity to hyperoxia", J. Biol. Chem. 272, 16644-16651.
  • de Haan, J.B., Bladier, C., Griggiths, P., Keiner, M., O'Shea, R.D., Cheung, N.S., Bronson, R.T., Silvestro, M.J., Wild, S., Zheng, S.S., Beart, P.M., Hertzog, P.J. and Kola, I. (1998) "Mice with a homozygous null mutation for the most abundant gluthathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide", J. Biol. Chem. 273, 22528-22536.
  • Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y, Kawabata, M., Miyazono, K. and Ichijo, H. (1998) "Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1", EMBO J. 17, 2596-2606.
  • Ichijo, H. (1997) "Induction of apoptosis by ASKl, a mammalian MAPKKK that activates SAPK/JNK abd p38 signaling pathways", Science 275, 90-94.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.