- Lenaz, G., De Santis, A. and Bertoli, E. (1985) "A survey of the function and specificity of ubiquinone in the mitochondrial respiratory chain", In: Lenaz, G., ed, Coenzyme Q: Biochemistry, Bioenergeticus and Clinical Applications of Ubiquinone (Wiley, New York), pp 165 - 199
- Momose, K. and Rudney, H. (1972) "3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p -hydroxybenzoate and isopentenylpyrophosphate", J. Biol. Chem. 247, 3930 - 3940
- Kalén, A., Appelkvist, E.L., Chojnacki, T. and Dallner, G. (1990) "Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver", J. Biol. Chem. 265, 1158 - 1164
- Teclebrhan, H., Jakobsson-Borin, Å., Brunk, U. and Dallner, G. (1995) "Relationship between the endoplasmic reticulum-Golgi membrane system and ubiquinone biosynthesis", Biochim. Biophys. Acta 1256, 157 - 165
- Kalén, A., Norling, B., Appelkvist, E.L. and Dallner, G. (1987) "Ubiquinone biosynthesis by the microsomal fraction from rat liver", Biochim. Biophys. Acta 926, 70 - 78
- Takahashi, T., Okamoto, T., Mori, K., Sayo, H. and Kishi, T. (1993) "Distribution of ubiquinone and ubiquinol homologues in rat tissues and subcellular fractions", Lipids 28, 803 - 809
- Åberg, F., Appelkvist, E.L., Dallner, G. and Ernster, L. (1992) "Distribution and redox state of ubiquinones in rat and human tissues", Arch. Biochem. Biophys. 295, 230 - 234
- Yamamoto, Y., Komuro, E. and Niki, E. (1990) "Antioxidant activity of ubiquinol in solution and phosphatidylcholine liposome", J. Nutr. Sci. Vitaminol. (Tokyo) 36, 505 - 511
- Stocker, R., Bowry, V.W. and Frei, B. (1991) "Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol", Proc. Natl Acad. Sci. USA 88, 1646 - 1650
- Mohr, D., Bowry, V.W. and Stocker, R. (1992) "Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation", Biochim. Biophys. Acta 1126, 247 - 254
- Beyer, R.E. (1988) "Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems", Free Radic. Biol. Med. 5, 297 - 303
- Ernster, L. and Dallner, G. (1995) "Biochemical, physiological and medical aspects of ubiquinone function", Biochim. Biophys. Acta 1272, 195 - 204
- Ernster, L. and Forsmark-Andrée, P. (1993) "Ubiquinol: an endogenous antioxidant in aerobic organisms", Clin. Invest. 71, S60 - S65
- Kishi, T., Takahashi, T., Usui, A. and Okamoto, T. (1999) "Ubiquinone redox cycle as a cellular antioxidant defense system", Biofactors 10, 131 - 138
- Navarro, F., Villalba, J.M., Crane, F.L., Mackellar, W.C. and Navas, P. (1995) "A phospholipid-dependent NADH-coenzyme Q reductase from liver plasma membrane", Biochem. Biophys. Res. Commun. 212, 138 - 143
- Villalba, J.M., Navarro, F., Gomez-Diaz, C., Arroyo, A., Bello, R.I. and Navas, P. (1997) "Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane", Mol. Asp. Med. 18, S7 - S13
- Shigemura, T., Kang, D., Nagata-Kuno, K., Takeshige, K. and Hamasaki, N. (1993) "Characterization of NAD(P)H-dependent ubiquinone reductase activities in rat liver microsomes", Biochim. Biophys. Acta 1141, 213 - 220
- Shimada, H., Hirai, K., Simamura, E. and Pan, J. (1998) "Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers", Arch. Biochem. Biophys. 351, 75 - 81
- Crane, F. and Morré, D.J. (1977) "Evidence for coenzyme Q function in Golgi membranes", In: Folkers, K. and Yamamura, Y., eds, Biomedical and Clinical Aspects of Coenzyme Q (Elsevier, Amsterdam), pp 3 - 14
- Villalba, J.M., Navarro, F., Córdoba, F., Serrano, A., Arroyo, A., Crane, F.L. and Navas, P. (1995) "Coenzyme Q reductase from liver plasma membrane: purification and role in trans -plasma-membrane electron transport", Proc. Natl Acad. Sci. USA 92, 4887 - 4891
- Ernster, L., Danielson, L. and Ljunggren, M. (1962) "DT diaphorase 1. Purification from the soluble fraction of rat-liver cytoplasm, and properties", Biochim. Biophys. Acta 58, 171 - 188
- Cadenas, E., Hochstein, P. and Ernster, L. (1992) "Pro- and antioxidant functions of quinones and quinone reductases in mammalian cells", Adv. Enzymol. Relat. Areas Mol. Biol. 65, 97 - 146
- Beyer, R.E., Segura-Aguilar, J.S., Di Bernardo, S., Cavazzoni, M., Feto, R., Fiorentini, D., Galli, M.C., Setti, M., Landi, L. and Lenaz, G. (1996) "The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems", Proc. Natl Acad. Sci. USA 93, 2528 - 2532
- Landi, L., Fiorentini, D., Galli, M.C., Segura-Aguilar, J. and Beyer, R.E. (1997) "DT-diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function", Free Radic. Biol. Med. 22, 329 - 335
- Takahashi, T., Shitashige, M., Okamoto, T., Kishi, T. and Goshima, K. (1992) "A novel ubiquinone reductase activity in rat cytosol", FEBS Lett. 314, 331 - 334
- Takahashi, T., Yamaguchi, T., Shitashige, M., Okamoto, T. and Kishi, T. (1995) "Reduction of ubiquinone in membrane lipids by rat liver cytosol and its involvement in the cellular defense system against lipid peroxidation", Biochem. J. 309, 883 - 890
- Takahashi, T., Okamoto, T. and Kishi, T. (1996) "Characterization of NADPH-dependent ubiquinone reductase activity in rat liver cytosol: effect of various factors on ubiquinone-reducing activity and discrimination from other quinone reductases", J. Biochem. (Tokyo) 119, 256 - 263
- Takahashi, T., Sugimoto, N., Takahata, K., Okamoto, T. and Kishi, T. (1996) "Cellular antioxidant defense by a ubiquinol-regenerating system coupled with cytosolic NADPH-dependent ubiquinone reductase: protective effect against carbon tetrachloride-induced hepatotoxicity in the rat", Biol. Pharm. Bull. 19, 1005 - 1012
- Takahashi, T., Hohda, T., Sugimoto, N., Mizobuchi, S., Okamoto, T., Mori, K. and Kishi, T. (1999) "Antioxidant roles of cellular ubiquinone and related redox cycles: potentiated resistance of rat hepatocytes having stimulated NADPH-dependent ubiquinone reductase against hydrogen peroxide toxicity", Biol. Pharm. Bull. 22, 1226 - 1233
- Hogeboom, G.H. (1955) "Fractionation of cell components of animal tissues", Methods Enzymol. 1, 16 - 19
- Moldéus, P., Högberg, J. and Orrenius, S. (1978) "Isolation and use of liver cells", Methods Enzymol. 52, 60 - 71
- Okamoto, T., Fukunaga, Y., Ida, Y. and Kishi, T. (1988) "Determination of reduced and total ubiquinones in biological materials by liquid chromatography with electro-chemical detection", J. Chromatogr. Biomed. Appl. 430, 11 - 19
- Ernster, L. (1967) "DT-diaphorase", Methods Enzymol. 10, 309 - 317
- Lowry, O.H., Rosenbrough, N.J., Farr, A.L. and Randall, R.J. (1951) "Protein measurement with the folin phenol reagent", J. Biol. Chem. 193, 265 - 275
- Buege, J.A. and Aust, S.D. (1978) "Microsomal lipid peroxidation", Methods Enzymol. 52, 302 - 310
- Silva, J.M., Ramakrishna Rao, D.N. and O'Brien, P.J. (1992) "Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions", Cancer Res. 52, 3015 - 3021
- Thor, H., Smith, M.T., Hartzell, P., Bellomo, G., Jewell, P. and Orrenius, S. (1982) "The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells", J. Biol. Chem. 257, 12419 - 12425
- Morrison, H., Jernström, B., Nordenskjöld, M., Thor, H. and Orrenius, S. (1984) "Induction of DNA damage by menadione(2-methyl-1,4--naphthoquinone) in primary cultures of rat hepatocytes", Biochem. Pharmacol. 33, 1763 - 1769
- Lind, C., Hochstein, P. and Ernster, L. (1982) "DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation", Arch. Biochem. Biophys. 216, 178 - 185
- Munday, R., Smith, B.L. and Munday, C.M. (1998) "Effects of butylated hydroxyanisole and dicumarol on the toxicity of menadione to rats", Chem.-Biol. Interact. 108, 155 - 170
- Radjendirane, V., Joseph, P., Lee, Y.-H., Kimura, S., Klein-Szanto, A.J.P., Gonzalez, F.J. and Jaiswal, A.K. (1998) "Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity", J. Biol. Chem. 273, 7382 - 7389
Effect of Dicumarol, a NAD(P)H: Quinone Acceptor Oxidoreductase 1 (DT-diaphorase) Inhibitor on Ubiquinone Redox Cycling in Cultured Rat Hepatocytes
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