Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens

References

• Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956; 2: 298–300
   Google Scholar
• Harman D. The biological clock: The mitocondria. J Am Geriatr Soc 1972; 20: 145–147
   PubMed Web of Science ®Google Scholar
• Miquel J, Economos AC, Fleming J, Johnson JEJ. Mitocondrial role in cell aging. Exp Gerontol 1980; 15: 579–591
   Google Scholar
• Beckman KB, Ames BN. Mitochondrial aging: Open questions. Ann N Y Acad Sci 1998; 854: 118–127
   PubMed Web of Science ®Google Scholar
• Barja de Quiroga C. Mitochondrial oxygen radical generation and leak: Sites of production in states 4 and 3, organ specificity and relation to aging and longevity. J Bioenergetics Biomembranes 1999; 31: 347–366
   PubMedGoogle Scholar
• Weindruch R, Sohal RS. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med 1997; 337: 986–994
   PubMed Web of Science ®Google Scholar
• Navarro-Arevalo A, Canavate C, Sanchez-del-Pino MJ. Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training. Mech Aging Dev 1999; 108: 207–217
   PubMedGoogle Scholar
• Barja G, Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 2000; 14: 312–318
   PubMed Web of Science ®Google Scholar
• Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996; 273: 59–63
   PubMed Web of Science ®Google Scholar
• Miquel J, Economos AC. Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Exp Gerontol 1979; 14: 279–285
   PubMed Web of Science ®Google Scholar
• Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 1994; 263: 1128–1130
   PubMed Web of Science ®Google Scholar
• Sastre J, Pallardo FV, Pla R, Pellin A, Juan G, O'Connor JE, Estrela JM, Miquel J, Vina J. Aging of the liver: Age-associated mitochondrial damage in intact hepatocytes. Hepatology 1996; 24: 1199–1205
   PubMed Web of Science ®Google Scholar
• Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci USA 1997; 94: 3064–3069
   PubMed Web of Science ®Google Scholar
• García de la Asunción J, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo PV, Sastre J, Viña J. Mitochondiral glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J 1996; 10: 333–338
   PubMed Web of Science ®Google Scholar
• Boveris A, Chance B. The mitocondrial generation of hydrogen peroxide. Biochem J 1973; 134: 707–716
   PubMed Web of Science ®Google Scholar
• Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979; 59: 527–605
   PubMed Web of Science ®Google Scholar
• Forman HJ, Azzi A. On the virtual existence of superoxide anions in mitochondria: Thoughts regarding its role in pathophysiology. FASEB J 1997; 11: 374–375
   PubMed Web of Science ®Google Scholar
• Ku HH, Brunk UT, Sohal RS. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radic Biol Med 1993; 15: 621–627
   PubMed Web of Science ®Google Scholar
• Sohal RS, Svensson I, Brunk UT. Hydrogen peroxide production by liver mitochondria in different species. Mech Aging Dev 1990; 53: 209–215
   PubMed Web of Science ®Google Scholar
• Benzi G, Moretti A. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic Biol Med 1995; 19: 77–101
   PubMed Web of Science ®Google Scholar
• Sastre J, Millan A, Garcia de la Asuncion J, Pla R, Juan G, Pallardo FV, O'Connor E, Martin JA, Droy-Lefaix MT, Vina J. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med 1998; 24: 298–304
   PubMed Web of Science ®Google Scholar
• Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994; 91: 10771–10778
   PubMed Web of Science ®Google Scholar
• Vina J, Sastre J, Anton V, Bruseghini L, Esteras A, Asensi M. Effect of aging on glutathione metabolism. Protection by antioxidants. EXS 1992; 62: 136–144
   PubMedGoogle Scholar
• Fernandez Ballesteros R. Aging in Europe—European Aging. IVth European Congress of Gerontology. Berlin, Germany, July 7–11, 1999. Abstr Z Gerontol Geriatr 1999; 32(Suppl 2)299–312, II1–298
   Google Scholar
• Borras C, Sastre J, Garcia-Sala D, Lloret A, Pallardo FV, Vina J. Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males. Free Radic Biol Med 2003; 34: 546–552
   PubMed Web of Science ®Google Scholar
• Evans DA, Burbach JP, van Leeuwen FW. Somatic mutations in the brain: Relationship to aging?. Mutat Res 1995; 338: 173–182
   PubMedGoogle Scholar
• Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Aging Dev 1994; 76: 215–224
   PubMed Web of Science ®Google Scholar
• Borras C, Gambini J, Gomez-Cabrera MC, Sastre J, Pallardo FV, Mann GE, Vina J. 17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade. Aging Cell 2005; 4: 113–118
   PubMed Web of Science ®Google Scholar
• Vina J, Borras C, Gambini J, Sastre J, Pallardo FV. Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. FEBS Lett 2005; 579: 2541–2545
   PubMed Web of Science ®Google Scholar
• Wallace DC. Mitochondrial DNA sequence variation in human evolution and disease. Proc Natl Acad Sci USA 1994; 91: 8739–8746
   PubMed Web of Science ®Google Scholar
• Shigenaga MK, Ames BN. Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage. Free Radic Biol Med 1991; 10: 211–216
   PubMed Web of Science ®Google Scholar
• Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci 1988; 85: 6465–6467
   PubMed Web of Science ®Google Scholar
• Vina J, Sastre J, Pallardo F, Borras C. Mitochondrial theory of aging: Importance to explain why females live longer than males. Antioxid Redox Signal 2003; 5: 549–556
   PubMed Web of Science ®Google Scholar
• Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 1986; 7: 1849–1851
   PubMed Web of Science ®Google Scholar
• Arnal JF, Clamens S, Pechet C, Negre-Salvayre A, Allera C, Girolami JP, Salvayre R, Bayard F. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production. Proc Natl Acad Sci USA 1996; 93: 4108–4113
   PubMed Web of Science ®Google Scholar
• Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, McCleary CA, Klein RA, Hake AM, Farlow MR. Estrogen for Alzheimer's disease in women: Randomized, double-blind, placebo-controlled trial. Neurology 2000; 54: 295–301
   PubMed Web of Science ®Google Scholar
• Pinto RE, Bartley W. The nature of the sex-linked differences in glutathione peroxidase activity and aerobic oxidation of glutathione in male and female rat liver. Biochem J 1969; 115: 449–456
   PubMed Web of Science ®Google Scholar
• Ruiz-Larrea MB, Leal AM, Martin C, Martinez R, Lacort M. Antioxidant action of estrogens in rat hepatocytes. Rev Esp Fisiol 1997; 53: 225–229
   PubMedGoogle Scholar
• Calleja M, Pena P, Ugalde C, Ferreiro C, Marco R, Garesse R. Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced. J Biol Chem 1993; 268: 18891–18897
   PubMedGoogle Scholar
• Crawford DR, Wang Y, Schools GP, Kochheiser J, Davies KJ. Down-regulation of mammalian mitochondrial RNAs during oxidative stress. Free Radic Biol Med 1997; 22: 551–559
   PubMed Web of Science ®Google Scholar
• Nina J, Hems R, Krebs HA. Maintenance of glutathione content is isolated hepatocyctes. Biochem J 1978; 170: 627–630
   PubMedGoogle Scholar
• Hazelton GA, Lang CA. Glutathione levels during the mosquito life span with emphasis on senescence. Proc Soc Exp Biol Med 1984; 176: 249–256
   PubMed Web of Science ®Google Scholar
• Sastre J, Pallardo FV, Garcia de la Asuncion J, Vina J. Mitochondria, oxidative stress and aging. Free Radic Res 2000; 32: 189–198
   PubMed Web of Science ®Google Scholar
• Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288: 321–333
   PubMed Web of Science ®Google Scholar
• Munro IC, Harwood M, Hlywka JJ, Stephen AM, Doull J, Flamm WG, Adlercreutz H. Soy isoflavones: A safety review. Nutr Rev 2003; 61: 1–33
   PubMed Web of Science ®Google Scholar
• Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, Vina J, Aaronson PI, Mann GE. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J 2005; 19: 1755–1757
   PubMed Web of Science ®Google Scholar
• Chen CY, Bakhiet RM. Age decreased steady-state concentrations of genistein in plasma, liver, and skeletal muscle in Sprague-Dawley rats. Mech Ageing Dev 2006; 127(4)344–348
   PubMedGoogle Scholar
• Gentili C, de Boland AR. Age-related decline in mitogen-activated protein kinase phosphorylation in PTH-stimulated rat enterocytes. Exp Gerontol 2000; 35(8)1003–1015
   PubMedGoogle Scholar
• Park D, Huang T, Frishman WH. Phytoestrogens as cardioprotective agents. Cardiol Rev 2005; 13: 13–17
   PubMedGoogle Scholar
• Borrás C, Gambini J, Gómez-Cabrera MC, Sastre J, Pallardó FV, Mann GE, Viña J. Genistein, a soy isoflavone, upregulates expression of antioxidant genes: Involvement of estrogen receptors, ERK1/2 and NFkappaB. FASEB J 2006, in press
   PubMedGoogle Scholar